-- dump date 20110803_090500 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type KLTH0A00110g 255710381 8290257 complement(2436..2909) 1 NC_013077.1 conserved hypothetical protein; KLTH0A00110p 2909 8290257 KLTH0A00110g Lachancea thermotolerans CBS 6340 KLTH0A00110p XP_002551474.1 2436 R 559295 CDS KLTH0A00220g 255710383 8290262 complement(17344..17547) 1 NC_013077.1 conserved hypothetical protein; KLTH0A00220p 17547 8290262 KLTH0A00220g Lachancea thermotolerans CBS 6340 KLTH0A00220p XP_002551475.1 17344 R 559295 CDS KLTH0A00242g 255710385 8290263 18502..19083 1 NC_013077.1 conserved hypothetical protein; KLTH0A00242p 19083 8290263 KLTH0A00242g Lachancea thermotolerans CBS 6340 KLTH0A00242p XP_002551476.1 18502 D 559295 CDS KLTH0A00264g 255710387 8290264 complement(21453..21722) 1 NC_013077.1 conserved hypothetical protein; KLTH0A00264p 21722 8290264 KLTH0A00264g Lachancea thermotolerans CBS 6340 KLTH0A00264p XP_002551477.1 21453 R 559295 CDS KLTH0A00308g 255710389 8290266 23428..25053 1 NC_013077.1 weakly similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L- glutamate and L-aspartate; KLTH0A00308p 25053 8290266 KLTH0A00308g Lachancea thermotolerans CBS 6340 KLTH0A00308p XP_002551478.1 23428 D 559295 CDS KLTH0A00374g 255710391 8290269 29810..30532 1 NC_013077.1 similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W Hypothetical ORF; KLTH0A00374p 30532 8290269 KLTH0A00374g Lachancea thermotolerans CBS 6340 KLTH0A00374p XP_002551479.1 29810 D 559295 CDS KLTH0A00418g 255710393 8290271 complement(34685..35755) 1 NC_013077.1 similar to uniprot|P00331 Saccharomyces cerevisiae YMR303C ADH2 Glucose-repressible alcohol dehydrogenase II involved in the production of certain carboxylate esters; KLTH0A00418p 35755 8290271 KLTH0A00418g Lachancea thermotolerans CBS 6340 KLTH0A00418p XP_002551480.1 34685 R 559295 CDS KLTH0A00440g 255710395 8290272 37100..38848 1 NC_013077.1 weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake; KLTH0A00440p 38848 8290272 KLTH0A00440g Lachancea thermotolerans CBS 6340 KLTH0A00440p XP_002551481.1 37100 D 559295 CDS KLTH0A00462g 255710397 8290273 40190..41299 1 NC_013077.1 some similarities with uniprot|Q04179 Saccharomyces cerevisiae YDR400W URH1 uridine nucleosidase (uridine ribohydrolase); KLTH0A00462p 41299 8290273 KLTH0A00462g Lachancea thermotolerans CBS 6340 KLTH0A00462p XP_002551482.1 40190 D 559295 CDS KLTH0A00484g 255710399 8290274 42443..44149 1 NC_013077.1 conserved hypothetical protein; KLTH0A00484p 44149 8290274 KLTH0A00484g Lachancea thermotolerans CBS 6340 KLTH0A00484p XP_002551483.1 42443 D 559295 CDS KLTH0A00506g 255710401 8290275 complement(44472..45476) 1 NC_013077.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF; KLTH0A00506p 45476 8290275 KLTH0A00506g Lachancea thermotolerans CBS 6340 KLTH0A00506p XP_002551484.1 44472 R 559295 CDS KLTH0A00528g 255710403 8290276 complement(46253..47173) 1 NC_013077.1 similar to uniprot|P14065 Saccharomyces cerevisiae YOR120W GCY1 Putative NADP( ) coupled glycerol dehydrogenase proposed to be involved in an alternative pathway for glycerol catabolism; KLTH0A00528p 47173 8290276 KLTH0A00528g Lachancea thermotolerans CBS 6340 KLTH0A00528p XP_002551485.1 46253 R 559295 CDS KLTH0A00550g 255710405 8290277 complement(49572..53438) 1 NC_013077.1 some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); KLTH0A00550p 53438 8290277 KLTH0A00550g Lachancea thermotolerans CBS 6340 KLTH0A00550p XP_002551486.1 49572 R 559295 CDS KLTH0A00572g 255710407 8290278 complement(56698..58713) 1 NC_013077.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase reduces siderophore-bound iron prior to uptake by transporters expression induced by low iron levels; KLTH0A00572p 58713 8290278 KLTH0A00572g Lachancea thermotolerans CBS 6340 KLTH0A00572p XP_002551487.1 56698 R 559295 CDS KLTH0A00594g 255710409 8290279 complement(59312..60421) 1 NC_013077.1 similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2; KLTH0A00594p 60421 8290279 KLTH0A00594g Lachancea thermotolerans CBS 6340 KLTH0A00594p XP_002551488.1 59312 R 559295 CDS KLTH0A00616g 255710411 8290280 61421..63292 1 NC_013077.1 similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82; KLTH0A00616p 63292 8290280 KLTH0A00616g Lachancea thermotolerans CBS 6340 KLTH0A00616p XP_002551489.1 61421 D 559295 CDS KLTH0A00638g 255710413 8290281 complement(63363..67598) 1 NC_013077.1 similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain; KLTH0A00638p 67598 8290281 KLTH0A00638g Lachancea thermotolerans CBS 6340 KLTH0A00638p XP_002551490.1 63363 R 559295 CDS KLTH0A00660g 255710415 8290282 complement(join(68319..68766,68848..68867)) 1 NC_013077.1 highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; KLTH0A00660p 68867 8290282 KLTH0A00660g Lachancea thermotolerans CBS 6340 KLTH0A00660p XP_002551491.1 68319 R 559295 CDS KLTH0A00682g 255710417 8290283 69084..70385 1 NC_013077.1 similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers; KLTH0A00682p 70385 8290283 KLTH0A00682g Lachancea thermotolerans CBS 6340 KLTH0A00682p XP_002551492.1 69084 D 559295 CDS KLTH0A00704g 255710419 8290284 complement(70544..72592) 1 NC_013077.1 some similarities with uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy; KLTH0A00704p 72592 8290284 KLTH0A00704g Lachancea thermotolerans CBS 6340 KLTH0A00704p XP_002551493.1 70544 R 559295 CDS KLTH0A00726g 255710421 8290285 complement(72979..77517) 1 NC_013077.1 highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1 6- amyloglucosidase activities required for glycogen degradation; KLTH0A00726p 77517 8290285 KLTH0A00726g Lachancea thermotolerans CBS 6340 KLTH0A00726p XP_002551494.1 72979 R 559295 CDS KLTH0A00748g 255710423 8290286 complement(78506..79303) 1 NC_013077.1 highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P- Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation; KLTH0A00748p 79303 8290286 KLTH0A00748g Lachancea thermotolerans CBS 6340 KLTH0A00748p XP_002551495.1 78506 R 559295 CDS KLTH0A00770g 255710425 8290287 complement(join(80170..80442,80507..80515)) 1 NC_013077.1 similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein; KLTH0A00770p 80515 8290287 KLTH0A00770g Lachancea thermotolerans CBS 6340 KLTH0A00770p XP_002551496.1 80170 R 559295 CDS KLTH0A00792g 255710427 8290288 complement(80668..81840) 1 NC_013077.1 similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI; KLTH0A00792p 81840 8290288 KLTH0A00792g Lachancea thermotolerans CBS 6340 KLTH0A00792p XP_002551497.1 80668 R 559295 CDS KLTH0A00814g 255710429 8290289 84356..86656 1 NC_013077.1 highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein; KLTH0A00814p 86656 8290289 KLTH0A00814g Lachancea thermotolerans CBS 6340 KLTH0A00814p XP_002551498.1 84356 D 559295 CDS KLTH0A00836g 255710431 8290290 complement(86917..87879) 1 NC_013077.1 similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability; KLTH0A00836p 87879 8290290 KLTH0A00836g Lachancea thermotolerans CBS 6340 KLTH0A00836p XP_002551499.1 86917 R 559295 CDS KLTH0A00858g 255710433 8290291 88180..90123 1 NC_013077.1 similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C; KLTH0A00858p 90123 8290291 KLTH0A00858g Lachancea thermotolerans CBS 6340 KLTH0A00858p XP_002551500.1 88180 D 559295 CDS KLTH0A00880g 255710435 8290292 complement(90125..91540) 1 NC_013077.1 similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex; KLTH0A00880p 91540 8290292 KLTH0A00880g Lachancea thermotolerans CBS 6340 KLTH0A00880p XP_002551501.1 90125 R 559295 CDS KLTH0A00902g 255710437 8290293 91636..92610 1 NC_013077.1 highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; KLTH0A00902p 92610 8290293 KLTH0A00902g Lachancea thermotolerans CBS 6340 KLTH0A00902p XP_002551502.1 91636 D 559295 CDS KLTH0A00924g 255710439 8290294 complement(92634..94724) 1 NC_013077.1 similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate; KLTH0A00924p 94724 8290294 KLTH0A00924g Lachancea thermotolerans CBS 6340 KLTH0A00924p XP_002551503.1 92634 R 559295 CDS KLTH0A00946g 255710441 8290295 94999..95904 1 NC_013077.1 weakly similar to uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition; KLTH0A00946p 95904 8290295 KLTH0A00946g Lachancea thermotolerans CBS 6340 KLTH0A00946p XP_002551504.1 94999 D 559295 CDS KLTH0A00968g 255710443 8290296 96149..97432 1 NC_013077.1 highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA- type ATPase; KLTH0A00968p 97432 8290296 KLTH0A00968g Lachancea thermotolerans CBS 6340 KLTH0A00968p XP_002551505.1 96149 D 559295 CDS KLTH0A00990g 255710445 8290297 complement(97551..98183) 1 NC_013077.1 similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; KLTH0A00990p 98183 8290297 KLTH0A00990g Lachancea thermotolerans CBS 6340 KLTH0A00990p XP_002551506.1 97551 R 559295 CDS KLTH0A01012g 255710447 8290298 complement(98450..99379) 1 NC_013077.1 similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Hypothetical ORF; KLTH0A01012p 99379 8290298 KLTH0A01012g Lachancea thermotolerans CBS 6340 KLTH0A01012p XP_002551507.1 98450 R 559295 CDS KLTH0A01034g 255710449 8290299 100382..101902 1 NC_013077.1 similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; KLTH0A01034p 101902 8290299 KLTH0A01034g Lachancea thermotolerans CBS 6340 KLTH0A01034p XP_002551508.1 100382 D 559295 CDS KLTH0A01056g 255710451 8290300 complement(101960..104230) 1 NC_013077.1 similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton; KLTH0A01056p 104230 8290300 KLTH0A01056g Lachancea thermotolerans CBS 6340 KLTH0A01056p XP_002551509.1 101960 R 559295 CDS KLTH0A01078g 255710453 8290301 complement(join(104423..104531,104620..104750,104853..104870)) 1 NC_013077.1 highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B; KLTH0A01078p 104870 8290301 KLTH0A01078g Lachancea thermotolerans CBS 6340 KLTH0A01078p XP_002551510.1 104423 R 559295 CDS KLTH0A01122g 255710455 8290303 complement(join(105295..105709,106054..106073)) 1 NC_013077.1 highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Bp and has similarity to rat S19 ribosomal protein; KLTH0A01122p 106073 8290303 KLTH0A01122g Lachancea thermotolerans CBS 6340 KLTH0A01122p XP_002551511.1 105295 R 559295 CDS KLTH0A01144g 255710457 8290304 complement(join(106916..107364,107680..107791)) 1 NC_013077.1 highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A and highly similar to uniprot|P07279 Saccharomyces cerevisiae YNL301C RPL18B Protein component of the large (60S) ribosomal subunit; KLTH0A01144p 107791 8290304 KLTH0A01144g Lachancea thermotolerans CBS 6340 KLTH0A01144p XP_002551512.1 106916 R 559295 CDS KLTH0A01166g 255710459 8290305 complement(108732..110162) 1 NC_013077.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; KLTH0A01166p 110162 8290305 KLTH0A01166g Lachancea thermotolerans CBS 6340 KLTH0A01166p XP_002551513.1 108732 R 559295 CDS KLTH0A01188g 255710461 8290306 complement(110365..110928) 1 NC_013077.1 weakly similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; KLTH0A01188p 110928 8290306 KLTH0A01188g Lachancea thermotolerans CBS 6340 KLTH0A01188p XP_002551514.1 110365 R 559295 CDS KLTH0A01210g 255710463 8290307 111361..113199 1 NC_013077.1 some similarities with uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit; KLTH0A01210p 113199 8290307 KLTH0A01210g Lachancea thermotolerans CBS 6340 KLTH0A01210p XP_002551515.1 111361 D 559295 CDS KLTH0A01232g 255710465 8290308 113770..114303 1 NC_013077.1 conserved hypothetical protein; KLTH0A01232p 114303 8290308 KLTH0A01232g Lachancea thermotolerans CBS 6340 KLTH0A01232p XP_002551516.1 113770 D 559295 CDS KLTH0A01254g 255710467 8290309 114559..115443 1 NC_013077.1 some similarities with uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus; KLTH0A01254p 115443 8290309 KLTH0A01254g Lachancea thermotolerans CBS 6340 KLTH0A01254p XP_002551517.1 114559 D 559295 CDS KLTH0A01276g 255710469 8290310 115664..117493 1 NC_013077.1 similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation; KLTH0A01276p 117493 8290310 KLTH0A01276g Lachancea thermotolerans CBS 6340 KLTH0A01276p XP_002551518.1 115664 D 559295 CDS KLTH0A01298g 255710471 8290311 complement(117599..118156) 1 NC_013077.1 some similarities with uniprot|Q12322 Saccharomyces cerevisiae YOL114C Hypothetical ORF; KLTH0A01298p 118156 8290311 KLTH0A01298g Lachancea thermotolerans CBS 6340 KLTH0A01298p XP_002551519.1 117599 R 559295 CDS KLTH0A01320g 255710473 8290312 118671..121115 1 NC_013077.1 similar to uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42; KLTH0A01320p 121115 8290312 KLTH0A01320g Lachancea thermotolerans CBS 6340 KLTH0A01320p XP_002551520.1 118671 D 559295 CDS KLTH0A01342g 255710475 8290313 complement(121198..126042) 1 NC_013077.1 similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins; KLTH0A01342p 126042 8290313 KLTH0A01342g Lachancea thermotolerans CBS 6340 KLTH0A01342p XP_002551521.1 121198 R 559295 CDS KLTH0A01364g 255710477 8290314 126448..127878 1 NC_013077.1 weakly similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W Hypothetical ORF; KLTH0A01364p 127878 8290314 KLTH0A01364g Lachancea thermotolerans CBS 6340 KLTH0A01364p XP_002551522.1 126448 D 559295 CDS KLTH0A01386g 255710479 8290315 complement(127952..129517) 1 NC_013077.1 similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH; KLTH0A01386p 129517 8290315 KLTH0A01386g Lachancea thermotolerans CBS 6340 KLTH0A01386p XP_002551523.1 127952 R 559295 CDS KLTH0A01408g 255710481 8290316 129878..131578 1 NC_013077.1 similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W; KLTH0A01408p 131578 8290316 KLTH0A01408g Lachancea thermotolerans CBS 6340 KLTH0A01408p XP_002551524.1 129878 D 559295 CDS KLTH0A01430g 255710483 8290317 complement(131610..132350) 1 NC_013077.1 similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C Hypothetical ORF; KLTH0A01430p 132350 8290317 KLTH0A01430g Lachancea thermotolerans CBS 6340 KLTH0A01430p XP_002551525.1 131610 R 559295 CDS KLTH0A01452g 255710485 8290318 132363..133031 1 NC_013077.1 similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane; KLTH0A01452p 133031 8290318 KLTH0A01452g Lachancea thermotolerans CBS 6340 KLTH0A01452p XP_002551526.1 132363 D 559295 CDS KLTH0A01474g 255710487 8290319 133212..134447 1 NC_013077.1 similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase; KLTH0A01474p 134447 8290319 KLTH0A01474g Lachancea thermotolerans CBS 6340 KLTH0A01474p XP_002551527.1 133212 D 559295 CDS KLTH0A01496g 255710489 8290320 complement(134444..136030) 1 NC_013077.1 similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein; KLTH0A01496p 136030 8290320 KLTH0A01496g Lachancea thermotolerans CBS 6340 KLTH0A01496p XP_002551528.1 134444 R 559295 CDS KLTH0A01540g 255710491 8290322 137284..138270 1 NC_013077.1 highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; KLTH0A01540p 138270 8290322 KLTH0A01540g Lachancea thermotolerans CBS 6340 KLTH0A01540p XP_002551529.1 137284 D 559295 CDS KLTH0A01562g 255710493 8290323 complement(138389..140236) 1 NC_013077.1 similar to uniprot|P39980 Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates transcription is induced during iron deprivation and diauxic shift potentially phosphorylated by Cdc28p; KLTH0A01562p 140236 8290323 KLTH0A01562g Lachancea thermotolerans CBS 6340 KLTH0A01562p XP_002551530.1 138389 R 559295 CDS KLTH0A01584g 255710495 8290324 141289..142134 1 NC_013077.1 similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth; KLTH0A01584p 142134 8290324 KLTH0A01584g Lachancea thermotolerans CBS 6340 KLTH0A01584p XP_002551531.1 141289 D 559295 CDS KLTH0A01628g 255710497 8290619 143444..144091 1 NC_013077.1 conserved hypothetical protein; KLTH0A01628p 144091 8290619 KLTH0A01628g Lachancea thermotolerans CBS 6340 KLTH0A01628p XP_002551532.1 143444 D 559295 CDS KLTH0A01650g 255710499 8290326 144813..145172 1 NC_013077.1 conserved hypothetical protein; KLTH0A01650p 145172 8290326 KLTH0A01650g Lachancea thermotolerans CBS 6340 KLTH0A01650p XP_002551533.1 144813 D 559295 CDS KLTH0A01672g 255710501 8290327 145378..146538 1 NC_013077.1 similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4- NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p; KLTH0A01672p 146538 8290327 KLTH0A01672g Lachancea thermotolerans CBS 6340 KLTH0A01672p XP_002551534.1 145378 D 559295 CDS KLTH0A01694g 255710503 8290328 146853..149654 1 NC_013077.1 highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo; KLTH0A01694p 149654 8290328 KLTH0A01694g Lachancea thermotolerans CBS 6340 KLTH0A01694p XP_002551535.1 146853 D 559295 CDS KLTH0A01716g 255710505 8290329 149859..150749 1 NC_013077.1 similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p may be involved in U2 snRNA folding contains two RNA recognition motifs (RRMs); KLTH0A01716p 150749 8290329 KLTH0A01716g Lachancea thermotolerans CBS 6340 KLTH0A01716p XP_002551536.1 149859 D 559295 CDS KLTH0A01782g 255710507 8290332 152482..153663 1 NC_013077.1 highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF; KLTH0A01782p 153663 8290332 KLTH0A01782g Lachancea thermotolerans CBS 6340 KLTH0A01782p XP_002551537.1 152482 D 559295 CDS KLTH0A01804g 255710509 8290333 complement(153812..154807) 1 NC_013077.1 similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C; KLTH0A01804p 154807 8290333 KLTH0A01804g Lachancea thermotolerans CBS 6340 KLTH0A01804p XP_002551538.1 153812 R 559295 CDS KLTH0A01826g 255710511 8290334 155431..158223 1 NC_013077.1 similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N- acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis; KLTH0A01826p 158223 8290334 KLTH0A01826g Lachancea thermotolerans CBS 6340 KLTH0A01826p XP_002551539.1 155431 D 559295 CDS KLTH0A01848g 255710513 8290335 complement(158347..159708) 1 NC_013077.1 conserved hypothetical protein; KLTH0A01848p 159708 8290335 KLTH0A01848g Lachancea thermotolerans CBS 6340 KLTH0A01848p XP_002551540.1 158347 R 559295 CDS KLTH0A01870g 255710515 8290336 160925..164152 1 NC_013077.1 similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan; KLTH0A01870p 164152 8290336 KLTH0A01870g Lachancea thermotolerans CBS 6340 KLTH0A01870p XP_002551541.1 160925 D 559295 CDS KLTH0A01892g 255710517 8290337 complement(164315..164866) 1 NC_013077.1 similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP- ribose 1''-phosphate a tRNA splicing metabolite may have a role in regulation of tRNA splicing; KLTH0A01892p 164866 8290337 KLTH0A01892g Lachancea thermotolerans CBS 6340 KLTH0A01892p XP_002551542.1 164315 R 559295 CDS KLTH0A01914g 255710519 8290338 complement(165071..169570) 1 NC_013077.1 similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter; KLTH0A01914p 169570 8290338 KLTH0A01914g Lachancea thermotolerans CBS 6340 KLTH0A01914p XP_002551543.1 165071 R 559295 CDS KLTH0A01936g 255710521 8290339 complement(171070..172647) 1 NC_013077.1 similar to uniprot|P04385 Saccharomyces cerevisiae YBR020W GAL1 Galactokinase phosphorylates alpha-D- galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism expression regulated by Gal4p and similar to YDR009W uniprot|P13045 Saccharomyces cerevisiae YDR009W GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose forms a complex with Gal80p and Gal4p to relieve inhibition by Gal80p binds galactose and ATP but does not have galactokinase activity; KLTH0A01936p 172647 8290339 KLTH0A01936g Lachancea thermotolerans CBS 6340 KLTH0A01936p XP_002551544.1 171070 R 559295 CDS KLTH0A01958g 255710523 8290340 172931..174997 1 NC_013077.1 similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta- anomers; KLTH0A01958p 174997 8290340 KLTH0A01958g Lachancea thermotolerans CBS 6340 KLTH0A01958p XP_002551545.1 172931 D 559295 CDS KLTH0A01980g 255710525 8290341 175574..176677 1 NC_013077.1 similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase synthesizes glucose-1-phosphate and UDP-galactose from UDP- D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; KLTH0A01980p 176677 8290341 KLTH0A01980g Lachancea thermotolerans CBS 6340 KLTH0A01980p XP_002551546.1 175574 D 559295 CDS KLTH0A02024g 255710527 8290343 complement(177329..178861) 1 NC_013077.1 similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF; KLTH0A02024p 178861 8290343 KLTH0A02024g Lachancea thermotolerans CBS 6340 KLTH0A02024p XP_002551547.1 177329 R 559295 CDS KLTH0A02046g 255710529 8290344 179012..180424 1 NC_013077.1 similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle; KLTH0A02046p 180424 8290344 KLTH0A02046g Lachancea thermotolerans CBS 6340 KLTH0A02046p XP_002551548.1 179012 D 559295 CDS KLTH0A02068g 255710531 8290345 complement(180496..181434) 1 NC_013077.1 highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates; KLTH0A02068p 181434 8290345 KLTH0A02068g Lachancea thermotolerans CBS 6340 KLTH0A02068p XP_002551549.1 180496 R 559295 CDS KLTH0A02090g 255710533 8290346 181671..182171 1 NC_013077.1 similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen; KLTH0A02090p 182171 8290346 KLTH0A02090g Lachancea thermotolerans CBS 6340 KLTH0A02090p XP_002551550.1 181671 D 559295 CDS KLTH0A02112g 255710535 8290347 complement(182225..184768) 1 NC_013077.1 similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p; KLTH0A02112p 184768 8290347 KLTH0A02112g Lachancea thermotolerans CBS 6340 KLTH0A02112p XP_002551551.1 182225 R 559295 CDS KLTH0A02134g 255710537 8290348 complement(185373..186002) 1 NC_013077.1 similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro; KLTH0A02134p 186002 8290348 KLTH0A02134g Lachancea thermotolerans CBS 6340 KLTH0A02134p XP_002551552.1 185373 R 559295 CDS KLTH0A02178g 255710539 8290350 complement(186546..187715) 1 NC_013077.1 similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double- strand break repair; KLTH0A02178p 187715 8290350 KLTH0A02178g Lachancea thermotolerans CBS 6340 KLTH0A02178p XP_002551553.1 186546 R 559295 CDS KLTH0A02200g 255710541 8290351 187855..188559 1 NC_013077.1 highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression; KLTH0A02200p 188559 8290351 KLTH0A02200g Lachancea thermotolerans CBS 6340 KLTH0A02200p XP_002551554.1 187855 D 559295 CDS KLTH0A02222g 255710543 8290352 complement(188580..189911) 1 NC_013077.1 similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm; KLTH0A02222p 189911 8290352 KLTH0A02222g Lachancea thermotolerans CBS 6340 KLTH0A02222p XP_002551555.1 188580 R 559295 CDS KLTH0A02244g 255710545 8290353 190077..191873 1 NC_013077.1 similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP-dependent RNA helicase; KLTH0A02244p 191873 8290353 KLTH0A02244g Lachancea thermotolerans CBS 6340 KLTH0A02244p XP_002551556.1 190077 D 559295 CDS KLTH0A02266g 255710547 8290354 complement(191921..193264) 1 NC_013077.1 weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation; KLTH0A02266p 193264 8290354 KLTH0A02266g Lachancea thermotolerans CBS 6340 KLTH0A02266p XP_002551557.1 191921 R 559295 CDS KLTH0A02288g 255710549 8290355 193453..194400 1 NC_013077.1 highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p; KLTH0A02288p 194400 8290355 KLTH0A02288g Lachancea thermotolerans CBS 6340 KLTH0A02288p XP_002551558.1 193453 D 559295 CDS KLTH0A02310g 255710551 8290356 complement(194663..196456) 1 NC_013077.1 similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex; KLTH0A02310p 196456 8290356 KLTH0A02310g Lachancea thermotolerans CBS 6340 KLTH0A02310p XP_002551559.1 194663 R 559295 CDS KLTH0A02332g 255710553 8290357 complement(196782..200321) 1 NC_013077.1 similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein; KLTH0A02332p 200321 8290357 KLTH0A02332g Lachancea thermotolerans CBS 6340 KLTH0A02332p XP_002551560.1 196782 R 559295 CDS KLTH0A02354g 255710555 8290358 200459..202174 1 NC_013077.1 similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90; KLTH0A02354p 202174 8290358 KLTH0A02354g Lachancea thermotolerans CBS 6340 KLTH0A02354p XP_002551561.1 200459 D 559295 CDS KLTH0A02376g 255710557 8290359 complement(202248..204713) 1 NC_013077.1 similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W; KLTH0A02376p 204713 8290359 KLTH0A02376g Lachancea thermotolerans CBS 6340 KLTH0A02376p XP_002551562.1 202248 R 559295 CDS KLTH0A02398g 255710559 8290360 205005..205982 1 NC_013077.1 conserved hypothetical protein; KLTH0A02398p 205982 8290360 KLTH0A02398g Lachancea thermotolerans CBS 6340 KLTH0A02398p XP_002551563.1 205005 D 559295 CDS KLTH0A02420g 255710561 8290361 206631..207812 1 NC_013077.1 some similarities with uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF; KLTH0A02420p 207812 8290361 KLTH0A02420g Lachancea thermotolerans CBS 6340 KLTH0A02420p XP_002551564.1 206631 D 559295 CDS KLTH0A02442g 255710563 8290362 complement(207945..208304) 1 NC_013077.1 similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit; KLTH0A02442p 208304 8290362 KLTH0A02442g Lachancea thermotolerans CBS 6340 KLTH0A02442p XP_002551565.1 207945 R 559295 CDS KLTH0A02464g 255710565 8290363 208530..212180 1 NC_013077.1 similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift; KLTH0A02464p 212180 8290363 KLTH0A02464g Lachancea thermotolerans CBS 6340 KLTH0A02464p XP_002551566.1 208530 D 559295 CDS KLTH0A02486g 255710567 8290364 complement(212453..213508) 1 NC_013077.1 similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation; KLTH0A02486p 213508 8290364 KLTH0A02486g Lachancea thermotolerans CBS 6340 KLTH0A02486p XP_002551567.1 212453 R 559295 CDS KLTH0A02508g 255710569 8290365 213735..214325 1 NC_013077.1 highly similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER; KLTH0A02508p 214325 8290365 KLTH0A02508g Lachancea thermotolerans CBS 6340 KLTH0A02508p XP_002551568.1 213735 D 559295 CDS KLTH0A02530g 255710571 8290366 complement(214393..217569) 1 NC_013077.1 similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF; KLTH0A02530p 217569 8290366 KLTH0A02530g Lachancea thermotolerans CBS 6340 KLTH0A02530p XP_002551569.1 214393 R 559295 CDS KLTH0A02596g 255710573 8290369 219197..220147 1 NC_013077.1 similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD( )-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD( )-dependent histone deacetylase activity in vitro; KLTH0A02596p 220147 8290369 KLTH0A02596g Lachancea thermotolerans CBS 6340 KLTH0A02596p XP_002551570.1 219197 D 559295 CDS KLTH0A02618g 255710575 8290370 complement(220657..222417) 1 NC_013077.1 similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase; KLTH0A02618p 222417 8290370 KLTH0A02618g Lachancea thermotolerans CBS 6340 KLTH0A02618p XP_002551571.1 220657 R 559295 CDS KLTH0A02640g 255710577 8290371 complement(223366..225870) 1 NC_013077.1 similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative); KLTH0A02640p 225870 8290371 KLTH0A02640g Lachancea thermotolerans CBS 6340 KLTH0A02640p XP_002551572.1 223366 R 559295 CDS KLTH0A02662g 255710579 8290372 complement(226313..226954) 1 NC_013077.1 highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; KLTH0A02662p 226954 8290372 KLTH0A02662g Lachancea thermotolerans CBS 6340 KLTH0A02662p XP_002551573.1 226313 R 559295 CDS KLTH0A02684g 255710581 8290373 complement(227861..234283) 1 NC_013077.1 similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage; KLTH0A02684p 234283 8290373 KLTH0A02684g Lachancea thermotolerans CBS 6340 KLTH0A02684p XP_002551574.1 227861 R 559295 CDS KLTH0A02706g 255710583 8290374 complement(234723..238409) 1 NC_013077.1 similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure; KLTH0A02706p 238409 8290374 KLTH0A02706g Lachancea thermotolerans CBS 6340 KLTH0A02706p XP_002551575.1 234723 R 559295 CDS KLTH0A02728g 255710585 8290375 complement(238679..239092) 1 NC_013077.1 conserved hypothetical protein; KLTH0A02728p 239092 8290375 KLTH0A02728g Lachancea thermotolerans CBS 6340 KLTH0A02728p XP_002551576.1 238679 R 559295 CDS KLTH0A02750g 255710587 8290376 complement(239284..241545) 1 NC_013077.1 similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; KLTH0A02750p 241545 8290376 KLTH0A02750g Lachancea thermotolerans CBS 6340 KLTH0A02750p XP_002551577.1 239284 R 559295 CDS KLTH0A02772g 255710589 8290377 242885..244036 1 NC_013077.1 conserved hypothetical protein; KLTH0A02772p 244036 8290377 KLTH0A02772g Lachancea thermotolerans CBS 6340 KLTH0A02772p XP_002551578.1 242885 D 559295 CDS KLTH0A02794g 255710591 8290378 244936..245586 1 NC_013077.1 weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1); KLTH0A02794p 245586 8290378 KLTH0A02794g Lachancea thermotolerans CBS 6340 KLTH0A02794p XP_002551579.1 244936 D 559295 CDS KLTH0A02816g 255710593 8290379 245846..247783 1 NC_013077.1 similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex; KLTH0A02816p 247783 8290379 KLTH0A02816g Lachancea thermotolerans CBS 6340 KLTH0A02816p XP_002551580.1 245846 D 559295 CDS KLTH0A02838g 255710595 8290380 complement(247830..248717) 1 NC_013077.1 conserved hypothetical protein; KLTH0A02838p 248717 8290380 KLTH0A02838g Lachancea thermotolerans CBS 6340 KLTH0A02838p XP_002551581.1 247830 R 559295 CDS KLTH0A02860g 255710597 8290381 complement(248935..249249) 1 NC_013077.1 similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras- Pka pathways; KLTH0A02860p 249249 8290381 KLTH0A02860g Lachancea thermotolerans CBS 6340 KLTH0A02860p XP_002551582.1 248935 R 559295 CDS KLTH0A02882g 255710599 8290382 250221..251642 1 NC_013077.1 similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones; KLTH0A02882p 251642 8290382 KLTH0A02882g Lachancea thermotolerans CBS 6340 KLTH0A02882p XP_002551583.1 250221 D 559295 CDS KLTH0A02904g 255710601 8290383 251941..252447 1 NC_013077.1 similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF; KLTH0A02904p 252447 8290383 KLTH0A02904g Lachancea thermotolerans CBS 6340 KLTH0A02904p XP_002551584.1 251941 D 559295 CDS KLTH0A02926g 255710603 8290384 252789..254021 1 NC_013077.1 weakly similar to uniprot|Q12110 Saccharomyces cerevisiae YLR049C Hypothetical ORF; KLTH0A02926p 254021 8290384 KLTH0A02926g Lachancea thermotolerans CBS 6340 KLTH0A02926p XP_002551585.1 252789 D 559295 CDS KLTH0A02948g 255710605 8290385 254216..254689 1 NC_013077.1 similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6- phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA; KLTH0A02948p 254689 8290385 KLTH0A02948g Lachancea thermotolerans CBS 6340 KLTH0A02948p XP_002551586.1 254216 D 559295 CDS KLTH0A02970g 255710607 8290386 complement(join(254751..254954,255015..255041)) 1 NC_013077.1 highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2; KLTH0A02970p 255041 8290386 KLTH0A02970g Lachancea thermotolerans CBS 6340 KLTH0A02970p XP_002551587.1 254751 R 559295 CDS KLTH0A02992g 255710609 8290387 255982..257478 1 NC_013077.1 highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi- enzyme complexes; KLTH0A02992p 257478 8290387 KLTH0A02992g Lachancea thermotolerans CBS 6340 KLTH0A02992p XP_002551588.1 255982 D 559295 CDS KLTH0A03036g 255710611 8290389 complement(258170..260332) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03036p 260332 8290389 KLTH0A03036g Lachancea thermotolerans CBS 6340 KLTH0A03036p XP_002551589.1 258170 R 559295 CDS KLTH0A03058g 255710613 8290390 complement(261659..262357) 1 NC_013077.1 similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability; KLTH0A03058p 262357 8290390 KLTH0A03058g Lachancea thermotolerans CBS 6340 KLTH0A03058p XP_002551590.1 261659 R 559295 CDS KLTH0A03080g 255710615 8290391 262571..263257 1 NC_013077.1 weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex; KLTH0A03080p 263257 8290391 KLTH0A03080g Lachancea thermotolerans CBS 6340 KLTH0A03080p XP_002551591.1 262571 D 559295 CDS KLTH0A03102g 255710617 8290392 263585..265084 1 NC_013077.1 highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C; KLTH0A03102p 265084 8290392 KLTH0A03102g Lachancea thermotolerans CBS 6340 KLTH0A03102p XP_002551592.1 263585 D 559295 CDS KLTH0A03124g 255710619 8290393 complement(265273..265863) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03124p 265863 8290393 KLTH0A03124g Lachancea thermotolerans CBS 6340 KLTH0A03124p XP_002551593.1 265273 R 559295 CDS KLTH0A03146g 255710621 8290394 complement(266666..268573) 1 NC_013077.1 some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall; KLTH0A03146p 268573 8290394 KLTH0A03146g Lachancea thermotolerans CBS 6340 KLTH0A03146p XP_002551594.1 266666 R 559295 CDS KLTH0A03168g 255710623 8290395 complement(269073..270239) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03168p 270239 8290395 KLTH0A03168g Lachancea thermotolerans CBS 6340 KLTH0A03168p XP_002551595.1 269073 R 559295 CDS KLTH0A03190g 255710625 8290396 complement(270862..273408) 1 NC_013077.1 similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Protein involved in bud-site selection nutrient signaling and gene expression controlled by the TOR kinase diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0A03190p 273408 8290396 KLTH0A03190g Lachancea thermotolerans CBS 6340 KLTH0A03190p XP_002551596.1 270862 R 559295 CDS KLTH0A03212g 255710627 8290397 274770..277055 1 NC_013077.1 similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb; KLTH0A03212p 277055 8290397 KLTH0A03212g Lachancea thermotolerans CBS 6340 KLTH0A03212p XP_002551597.1 274770 D 559295 CDS KLTH0A03234g 255710629 8290398 277333..280440 1 NC_013077.1 similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; KLTH0A03234p 280440 8290398 KLTH0A03234g Lachancea thermotolerans CBS 6340 KLTH0A03234p XP_002551598.1 277333 D 559295 CDS KLTH0A03256g 255710631 8290399 complement(280633..281961) 1 NC_013077.1 similar to uniprot|P06842 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells; KLTH0A03256p 281961 8290399 KLTH0A03256g Lachancea thermotolerans CBS 6340 KLTH0A03256p XP_002551599.1 280633 R 559295 CDS KLTH0A03278g 255710633 8290400 283065..284783 1 NC_013077.1 highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane- spanning regions also involved in cysteine uptake; KLTH0A03278p 284783 8290400 KLTH0A03278g Lachancea thermotolerans CBS 6340 KLTH0A03278p XP_002551600.1 283065 D 559295 CDS KLTH0A03300g 255710635 8290401 complement(284917..286008) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03300p 286008 8290401 KLTH0A03300g Lachancea thermotolerans CBS 6340 KLTH0A03300p XP_002551601.1 284917 R 559295 CDS KLTH0A03322g 255710637 8290402 286223..288904 1 NC_013077.1 similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook; KLTH0A03322p 288904 8290402 KLTH0A03322g Lachancea thermotolerans CBS 6340 KLTH0A03322p XP_002551602.1 286223 D 559295 CDS KLTH0A03344g 255710639 8290403 289188..290636 1 NC_013077.1 highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; KLTH0A03344p 290636 8290403 KLTH0A03344g Lachancea thermotolerans CBS 6340 KLTH0A03344p XP_002551603.1 289188 D 559295 CDS KLTH0A03366g 255710641 8290404 complement(290685..291389) 1 NC_013077.1 similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen- regulated amino acid permease Gap1p from the Golgi to the cell surface; KLTH0A03366p 291389 8290404 KLTH0A03366g Lachancea thermotolerans CBS 6340 KLTH0A03366p XP_002551604.1 290685 R 559295 CDS KLTH0A03388g 255710643 8290405 complement(291551..293413) 1 NC_013077.1 some similarities with uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters; KLTH0A03388p 293413 8290405 KLTH0A03388g Lachancea thermotolerans CBS 6340 KLTH0A03388p XP_002551605.1 291551 R 559295 CDS KLTH0A03410g 255710645 8290406 293799..296219 1 NC_013077.1 similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF; KLTH0A03410p 296219 8290406 KLTH0A03410g Lachancea thermotolerans CBS 6340 KLTH0A03410p XP_002551606.1 293799 D 559295 CDS KLTH0A03432g 255710647 8290407 296563..297951 1 NC_013077.1 similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP- dependent protein kinase (PKA); KLTH0A03432p 297951 8290407 KLTH0A03432g Lachancea thermotolerans CBS 6340 KLTH0A03432p XP_002551607.1 296563 D 559295 CDS KLTH0A03454g 255710649 8290408 complement(298086..298532) 1 NC_013077.1 highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p; KLTH0A03454p 298532 8290408 KLTH0A03454g Lachancea thermotolerans CBS 6340 KLTH0A03454p XP_002551608.1 298086 R 559295 CDS KLTH0A03476g 255710651 8290409 complement(298735..299661) 1 NC_013077.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism; KLTH0A03476p 299661 8290409 KLTH0A03476g Lachancea thermotolerans CBS 6340 KLTH0A03476p XP_002551609.1 298735 R 559295 CDS KLTH0A03498g 255710653 8290410 complement(301696..303915) 1 NC_013077.1 weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrr1p acting on an overlapping set of target genes; KLTH0A03498p 303915 8290410 KLTH0A03498g Lachancea thermotolerans CBS 6340 KLTH0A03498p XP_002551610.1 301696 R 559295 CDS KLTH0A03520g 255710655 8290411 305601..306446 1 NC_013077.1 similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches; KLTH0A03520p 306446 8290411 KLTH0A03520g Lachancea thermotolerans CBS 6340 KLTH0A03520p XP_002551611.1 305601 D 559295 CDS KLTH0A03542g 255710657 8290412 306667..307803 1 NC_013077.1 highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2; KLTH0A03542p 307803 8290412 KLTH0A03542g Lachancea thermotolerans CBS 6340 KLTH0A03542p XP_002551612.1 306667 D 559295 CDS KLTH0A03564g 255710659 8290413 complement(join(307859..308965,309038..309100)) 1 NC_013077.1 weakly similar to to YER044C-A uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Functions in early recombination; mRNA is meiosis-specific and has 88 bp intron at 5' end spliced independently of MER1[INTRON]; KLTH0A03564p 309100 8290413 KLTH0A03564g Lachancea thermotolerans CBS 6340 KLTH0A03564p XP_002551613.1 307859 R 559295 CDS KLTH0A03586g 255710661 8290414 complement(309596..310870) 1 NC_013077.1 some similarities with uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non- optimal carbon sources; KLTH0A03586p 310870 8290414 KLTH0A03586g Lachancea thermotolerans CBS 6340 KLTH0A03586p XP_002551614.1 309596 R 559295 CDS KLTH0A03608g 255710663 8290415 311369..312109 1 NC_013077.1 similar to uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis; KLTH0A03608p 312109 8290415 KLTH0A03608g Lachancea thermotolerans CBS 6340 KLTH0A03608p XP_002551615.1 311369 D 559295 CDS KLTH0A03630g 255710665 8290416 312223..314028 1 NC_013077.1 conserved hypothetical protein; KLTH0A03630p 314028 8290416 KLTH0A03630g Lachancea thermotolerans CBS 6340 KLTH0A03630p XP_002551616.1 312223 D 559295 CDS KLTH0A03652g 255710667 8290417 314336..316654 1 NC_013077.1 some similarities with uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; KLTH0A03652p 316654 8290417 KLTH0A03652g Lachancea thermotolerans CBS 6340 KLTH0A03652p XP_002551617.1 314336 D 559295 CDS KLTH0A03674g 255710669 8290418 complement(316868..317992) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03674p 317992 8290418 KLTH0A03674g Lachancea thermotolerans CBS 6340 KLTH0A03674p XP_002551618.1 316868 R 559295 CDS KLTH0A03696g 255710671 8290419 complement(318721..321066) 1 NC_013077.1 similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system; KLTH0A03696p 321066 8290419 KLTH0A03696g Lachancea thermotolerans CBS 6340 KLTH0A03696p XP_002551619.1 318721 R 559295 CDS KLTH0A03718g 255710673 8290420 complement(321327..322751) 1 NC_013077.1 similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF; KLTH0A03718p 322751 8290420 KLTH0A03718g Lachancea thermotolerans CBS 6340 KLTH0A03718p XP_002551620.1 321327 R 559295 CDS KLTH0A03740g 255710675 8290421 complement(322936..324123) 1 NC_013077.1 similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family; KLTH0A03740p 324123 8290421 KLTH0A03740g Lachancea thermotolerans CBS 6340 KLTH0A03740p XP_002551621.1 322936 R 559295 CDS KLTH0A03762g 255710677 8290422 complement(324351..324800) 1 NC_013077.1 conserved hypothetical protein; KLTH0A03762p 324800 8290422 KLTH0A03762g Lachancea thermotolerans CBS 6340 KLTH0A03762p XP_002551622.1 324351 R 559295 CDS KLTH0A03850g 255710679 8290426 325998..326291 1 NC_013077.1 similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A; KLTH0A03850p 326291 8290426 KLTH0A03850g Lachancea thermotolerans CBS 6340 KLTH0A03850p XP_002551623.1 325998 D 559295 CDS KLTH0A03872g 255710681 8290427 326673..328547 1 NC_013077.1 similar to uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF; KLTH0A03872p 328547 8290427 KLTH0A03872g Lachancea thermotolerans CBS 6340 KLTH0A03872p XP_002551624.1 326673 D 559295 CDS KLTH0A03894g 255710683 8290428 complement(328648..329619) 1 NC_013077.1 similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; KLTH0A03894p 329619 8290428 KLTH0A03894g Lachancea thermotolerans CBS 6340 KLTH0A03894p XP_002551625.1 328648 R 559295 CDS KLTH0A03916g 255710685 8290429 329926..331167 1 NC_013077.1 similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF; KLTH0A03916p 331167 8290429 KLTH0A03916g Lachancea thermotolerans CBS 6340 KLTH0A03916p XP_002551626.1 329926 D 559295 CDS KLTH0A03938g 255710687 8290430 complement(331257..331772) 1 NC_013077.1 weakly similar to uniprot|P40033 Saccharomyces cerevisiae YER050C; KLTH0A03938p 331772 8290430 KLTH0A03938g Lachancea thermotolerans CBS 6340 KLTH0A03938p XP_002551627.1 331257 R 559295 CDS KLTH0A03960g 255710689 8290431 332436..333842 1 NC_013077.1 similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF; KLTH0A03960p 333842 8290431 KLTH0A03960g Lachancea thermotolerans CBS 6340 KLTH0A03960p XP_002551628.1 332436 D 559295 CDS KLTH0A03982g 255710691 8290432 334027..334890 1 NC_013077.1 similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase; KLTH0A03982p 334890 8290432 KLTH0A03982g Lachancea thermotolerans CBS 6340 KLTH0A03982p XP_002551629.1 334027 D 559295 CDS KLTH0A04004g 255710693 8290433 complement(335054..336622) 1 NC_013077.1 highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P- transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis; KLTH0A04004p 336622 8290433 KLTH0A04004g Lachancea thermotolerans CBS 6340 KLTH0A04004p XP_002551630.1 335054 R 559295 CDS KLTH0A04026g 255710695 8290434 complement(337200..337901) 1 NC_013077.1 weakly similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; KLTH0A04026p 337901 8290434 KLTH0A04026g Lachancea thermotolerans CBS 6340 KLTH0A04026p XP_002551631.1 337200 R 559295 CDS KLTH0A04048g 255710697 8290435 339253..340128 1 NC_013077.1 similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s); KLTH0A04048p 340128 8290435 KLTH0A04048g Lachancea thermotolerans CBS 6340 KLTH0A04048p XP_002551632.1 339253 D 559295 CDS KLTH0A04070g 255710699 8290436 complement(340333..341373) 1 NC_013077.1 similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Mir1p but less abundant than Mir1p under normal conditions expression is induced at high temperature; KLTH0A04070p 341373 8290436 KLTH0A04070g Lachancea thermotolerans CBS 6340 KLTH0A04070p XP_002551633.1 340333 R 559295 CDS KLTH0A04092g 255710701 8290437 complement(342925..344223) 1 NC_013077.1 weakly similar to uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p; KLTH0A04092p 344223 8290437 KLTH0A04092g Lachancea thermotolerans CBS 6340 KLTH0A04092p XP_002551634.1 342925 R 559295 CDS KLTH0A04114g 255710703 8290438 complement(344618..346594) 1 NC_013077.1 similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus; KLTH0A04114p 346594 8290438 KLTH0A04114g Lachancea thermotolerans CBS 6340 KLTH0A04114p XP_002551635.1 344618 R 559295 CDS KLTH0A04136g 255710705 8290439 complement(join(347041..347882,347949..348000)) 1 NC_013077.1 highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control; KLTH0A04136p 348000 8290439 KLTH0A04136g Lachancea thermotolerans CBS 6340 KLTH0A04136p XP_002551636.1 347041 R 559295 CDS KLTH0A04158g 255710707 8290440 348896..351466 1 NC_013077.1 similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein; KLTH0A04158p 351466 8290440 KLTH0A04158g Lachancea thermotolerans CBS 6340 KLTH0A04158p XP_002551637.1 348896 D 559295 CDS KLTH0A04180g 255710709 8290441 complement(351562..354954) 1 NC_013077.1 highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases; KLTH0A04180p 354954 8290441 KLTH0A04180g Lachancea thermotolerans CBS 6340 KLTH0A04180p XP_002551638.1 351562 R 559295 CDS KLTH0A04202g 255710711 8290442 complement(join(355181..355515,355934..355970)) 1 NC_013077.1 highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein; KLTH0A04202p 355970 8290442 KLTH0A04202g Lachancea thermotolerans CBS 6340 KLTH0A04202p XP_002551639.1 355181 R 559295 CDS KLTH0A04224g 255710713 8290443 complement(356660..357085) 1 NC_013077.1 highly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro; KLTH0A04224p 357085 8290443 KLTH0A04224g Lachancea thermotolerans CBS 6340 KLTH0A04224p XP_002551640.1 356660 R 559295 CDS KLTH0A04246g 255710715 8290444 357173..357541 1 NC_013077.1 similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase; KLTH0A04246p 357541 8290444 KLTH0A04246g Lachancea thermotolerans CBS 6340 KLTH0A04246p XP_002551641.1 357173 D 559295 CDS KLTH0A04268g 255710717 8290445 358035..359777 1 NC_013077.1 similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated; KLTH0A04268p 359777 8290445 KLTH0A04268g Lachancea thermotolerans CBS 6340 KLTH0A04268p XP_002551642.1 358035 D 559295 CDS KLTH0A04290g 255710719 8290446 361064..362614 1 NC_013077.1 similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease mediates purine (adenine guanine and hypoxanthine) and cytosine accumulation and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 Putative purine-cytosine permease; KLTH0A04290p 362614 8290446 KLTH0A04290g Lachancea thermotolerans CBS 6340 KLTH0A04290p XP_002551643.1 361064 D 559295 CDS KLTH0A04312g 255710721 8290447 362792..363535 1 NC_013077.1 similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth; KLTH0A04312p 363535 8290447 KLTH0A04312g Lachancea thermotolerans CBS 6340 KLTH0A04312p XP_002551644.1 362792 D 559295 CDS KLTH0A04334g 255710723 8290448 complement(363572..364846) 1 NC_013077.1 similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase; KLTH0A04334p 364846 8290448 KLTH0A04334g Lachancea thermotolerans CBS 6340 KLTH0A04334p XP_002551645.1 363572 R 559295 CDS KLTH0A04356g 255710725 8290449 complement(365149..365898) 1 NC_013077.1 similar to uniprot|P40106 Saccharomyces cerevisiae HOR2 and to YIL053W uniprot|P41277 Saccharomyces cerevisiae RHR2, two redundant DL-glycerol-3-phosphatases; KLTH0A04356p 365898 8290449 KLTH0A04356g Lachancea thermotolerans CBS 6340 KLTH0A04356p XP_002551646.1 365149 R 559295 CDS KLTH0A04378g 255710727 8290450 complement(366491..367240) 1 NC_013077.1 highly similar to uniprot|P40106 Saccharomyces cerevisiae HOR2 and to YIL053W uniprot|P41277 Saccharomyces cerevisiae RHR2, two redundant DL-glycerol-3- phosphatases; KLTH0A04378p 367240 8290450 KLTH0A04378g Lachancea thermotolerans CBS 6340 KLTH0A04378p XP_002551647.1 366491 R 559295 CDS KLTH0A04400g 255710729 8290451 368443..369036 1 NC_013077.1 some similarities with uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); (putative) involved in transcription; KLTH0A04400p 369036 8290451 KLTH0A04400g Lachancea thermotolerans CBS 6340 KLTH0A04400p XP_002551648.1 368443 D 559295 CDS KLTH0A04422g 255710731 8290452 369616..370812 1 NC_013077.1 some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF; KLTH0A04422p 370812 8290452 KLTH0A04422g Lachancea thermotolerans CBS 6340 KLTH0A04422p XP_002551649.1 369616 D 559295 CDS KLTH0A04444g 255710733 8290453 complement(371219..373240) 1 NC_013077.1 similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription; KLTH0A04444p 373240 8290453 KLTH0A04444g Lachancea thermotolerans CBS 6340 KLTH0A04444p XP_002551650.1 371219 R 559295 CDS KLTH0A04466g 255710735 8290454 complement(374411..376081) 1 NC_013077.1 highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose; KLTH0A04466p 376081 8290454 KLTH0A04466g Lachancea thermotolerans CBS 6340 KLTH0A04466p XP_002551651.1 374411 R 559295 CDS KLTH0A04510g 255710737 8290456 376970..377461 1 NC_013077.1 similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF; KLTH0A04510p 377461 8290456 KLTH0A04510g Lachancea thermotolerans CBS 6340 KLTH0A04510p XP_002551652.1 376970 D 559295 CDS KLTH0A04532g 255710739 8290457 378016..379851 1 NC_013077.1 similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C- terminal region of Not1p; KLTH0A04532p 379851 8290457 KLTH0A04532g Lachancea thermotolerans CBS 6340 KLTH0A04532p XP_002551653.1 378016 D 559295 CDS KLTH0A04554g 255710741 8290458 380152..380988 1 NC_013077.1 weakly similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog; KLTH0A04554p 380988 8290458 KLTH0A04554g Lachancea thermotolerans CBS 6340 KLTH0A04554p XP_002551654.1 380152 D 559295 CDS KLTH0A04576g 255710743 8290459 381267..383840 1 NC_013077.1 highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl- phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p; KLTH0A04576p 383840 8290459 KLTH0A04576g Lachancea thermotolerans CBS 6340 KLTH0A04576p XP_002551655.1 381267 D 559295 CDS KLTH0A04598g 255710745 8290460 384126..384587 1 NC_013077.1 highly similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; KLTH0A04598p 384587 8290460 KLTH0A04598g Lachancea thermotolerans CBS 6340 KLTH0A04598p XP_002551656.1 384126 D 559295 CDS KLTH0A04620g 255710747 8290461 384810..385973 1 NC_013077.1 some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p; KLTH0A04620p 385973 8290461 KLTH0A04620g Lachancea thermotolerans CBS 6340 KLTH0A04620p XP_002551657.1 384810 D 559295 CDS KLTH0A04642g 255710749 8290462 complement(386066..386755) 1 NC_013077.1 similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0A04642p 386755 8290462 KLTH0A04642g Lachancea thermotolerans CBS 6340 KLTH0A04642p XP_002551658.1 386066 R 559295 CDS KLTH0A04664g 255710751 8290463 386899..387363 1 NC_013077.1 similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division; KLTH0A04664p 387363 8290463 KLTH0A04664g Lachancea thermotolerans CBS 6340 KLTH0A04664p XP_002551659.1 386899 D 559295 CDS KLTH0A04686g 255710753 8290464 388330..390969 1 NC_013077.1 highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; KLTH0A04686p 390969 8290464 KLTH0A04686g Lachancea thermotolerans CBS 6340 KLTH0A04686p XP_002551660.1 388330 D 559295 CDS KLTH0A04708g 255710755 8290465 391244..393286 1 NC_013077.1 similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF; KLTH0A04708p 393286 8290465 KLTH0A04708g Lachancea thermotolerans CBS 6340 KLTH0A04708p XP_002551661.1 391244 D 559295 CDS KLTH0A04730g 255710757 8290466 393425..395821 1 NC_013077.1 similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; KLTH0A04730p 395821 8290466 KLTH0A04730g Lachancea thermotolerans CBS 6340 KLTH0A04730p XP_002551662.1 393425 D 559295 CDS KLTH0A04752g 255710759 8290467 complement(395850..396281) 1 NC_013077.1 weakly similar to uniprot|P40045 Saccharomyces cerevisiae YER071C Protein of unknown; KLTH0A04752p 396281 8290467 KLTH0A04752g Lachancea thermotolerans CBS 6340 KLTH0A04752p XP_002551663.1 395850 R 559295 CDS KLTH0A04774g 255710761 8290468 397090..397461 1 NC_013077.1 highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance; KLTH0A04774p 397461 8290468 KLTH0A04774g Lachancea thermotolerans CBS 6340 KLTH0A04774p XP_002551664.1 397090 D 559295 CDS KLTH0A04796g 255710763 8290469 398632..400185 1 NC_013077.1 highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme; KLTH0A04796p 400185 8290469 KLTH0A04796g Lachancea thermotolerans CBS 6340 KLTH0A04796p XP_002551665.1 398632 D 559295 CDS KLTH0A04818g 255710765 8290470 join(400870..400872,401278..401682) 1 NC_013077.1 highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B and highly similar to uniprot|P26782 Saccharomyces cerevisiae YER074W RPS24A proteins component of the small (40S) ribosomal subunit; KLTH0A04818p 401682 8290470 KLTH0A04818g Lachancea thermotolerans CBS 6340 KLTH0A04818p XP_002551666.1 400870 D 559295 CDS KLTH0A04840g 255710767 8290471 join(402770..402860,402930..403037,403105..403160) 1 NC_013077.1 highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Hypothetical ORF; KLTH0A04840p 403160 8290471 KLTH0A04840g Lachancea thermotolerans CBS 6340 KLTH0A04840p XP_002551667.1 402770 D 559295 CDS KLTH0A04862g 255710769 8290472 complement(403388..406003) 1 NC_013077.1 some similarities with uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen- activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm; KLTH0A04862p 406003 8290472 KLTH0A04862g Lachancea thermotolerans CBS 6340 KLTH0A04862p XP_002551668.1 403388 R 559295 CDS KLTH0A04884g 255710771 8290473 406887..407675 1 NC_013077.1 similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R; KLTH0A04884p 407675 8290473 KLTH0A04884g Lachancea thermotolerans CBS 6340 KLTH0A04884p XP_002551669.1 406887 D 559295 CDS KLTH0A04906g 255710773 8290474 complement(407728..409641) 1 NC_013077.1 similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF; KLTH0A04906p 409641 8290474 KLTH0A04906g Lachancea thermotolerans CBS 6340 KLTH0A04906p XP_002551670.1 407728 R 559295 CDS KLTH0A04928g 255710775 8290475 409825..411081 1 NC_013077.1 similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain; KLTH0A04928p 411081 8290475 KLTH0A04928g Lachancea thermotolerans CBS 6340 KLTH0A04928p XP_002551671.1 409825 D 559295 CDS KLTH0A04950g 255710777 8290476 complement(411162..412727) 1 NC_013077.1 similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF; KLTH0A04950p 412727 8290476 KLTH0A04950g Lachancea thermotolerans CBS 6340 KLTH0A04950p XP_002551672.1 411162 R 559295 CDS KLTH0A04972g 255710779 8290477 complement(join(412916..414017,414073..414785)) 1 NC_013077.1 similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation; KLTH0A04972p 414785 8290477 KLTH0A04972g Lachancea thermotolerans CBS 6340 KLTH0A04972p XP_002551673.1 412916 R 559295 CDS KLTH0A04994g 255710781 8290478 416070..416657 1 NC_013077.1 some similarities with uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF; KLTH0A04994p 416657 8290478 KLTH0A04994g Lachancea thermotolerans CBS 6340 KLTH0A04994p XP_002551674.1 416070 D 559295 CDS KLTH0A05016g 255710783 8290479 417016..418875 1 NC_013077.1 similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria; KLTH0A05016p 418875 8290479 KLTH0A05016g Lachancea thermotolerans CBS 6340 KLTH0A05016p XP_002551675.1 417016 D 559295 CDS KLTH0A05038g 255710785 8290480 419566..420978 1 NC_013077.1 highly similar to uniprot|P40510 and to YER081W uniprot|P40054 Saccharomyces cerevisiae SER3 3- phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p; KLTH0A05038p 420978 8290480 KLTH0A05038g Lachancea thermotolerans CBS 6340 KLTH0A05038p XP_002551676.1 419566 D 559295 CDS KLTH0A05060g 255710787 8290481 421308..424139 1 NC_013077.1 highly similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p; KLTH0A05060p 424139 8290481 KLTH0A05060g Lachancea thermotolerans CBS 6340 KLTH0A05060p XP_002551677.1 421308 D 559295 CDS KLTH0A05082g 255710789 8290482 complement(424327..425985) 1 NC_013077.1 highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C; KLTH0A05082p 425985 8290482 KLTH0A05082g Lachancea thermotolerans CBS 6340 KLTH0A05082p XP_002551678.1 424327 R 559295 CDS KLTH0A05104g 255710791 8290483 426808..428127 1 NC_013077.1 weakly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; KLTH0A05104p 428127 8290483 KLTH0A05104g Lachancea thermotolerans CBS 6340 KLTH0A05104p XP_002551679.1 426808 D 559295 CDS KLTH0A05126g 255710793 8290484 complement(428186..429157) 1 NC_013077.1 similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function; KLTH0A05126p 429157 8290484 KLTH0A05126g Lachancea thermotolerans CBS 6340 KLTH0A05126p XP_002551680.1 428186 R 559295 CDS KLTH0A05148g 255710795 8290485 complement(429228..430112) 1 NC_013077.1 similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p; KLTH0A05148p 430112 8290485 KLTH0A05148g Lachancea thermotolerans CBS 6340 KLTH0A05148p XP_002551681.1 429228 R 559295 CDS KLTH0A05170g 255710797 8290486 430306..431283 1 NC_013077.1 similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF; KLTH0A05170p 431283 8290486 KLTH0A05170g Lachancea thermotolerans CBS 6340 KLTH0A05170p XP_002551682.1 430306 D 559295 CDS KLTH0A05192g 255710799 8290487 complement(431378..433600) 1 NC_013077.1 highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic; KLTH0A05192p 433600 8290487 KLTH0A05192g Lachancea thermotolerans CBS 6340 KLTH0A05192p XP_002551683.1 431378 R 559295 CDS KLTH0A05214g 255710801 8290488 434058..435248 1 NC_013077.1 similar to uniprot|P40507 Saccharomyces cerevisiae YIL079C AIR1 and similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C AIR2; KLTH0A05214p 435248 8290488 KLTH0A05214g Lachancea thermotolerans CBS 6340 KLTH0A05214p XP_002551684.1 434058 D 559295 CDS KLTH0A05236g 255710803 8290489 435817..436212 1 NC_013077.1 similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane; KLTH0A05236p 436212 8290489 KLTH0A05236g Lachancea thermotolerans CBS 6340 KLTH0A05236p XP_002551685.1 435817 D 559295 CDS KLTH0A05258g 255710805 8290490 436670..437155 1 NC_013077.1 similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF; KLTH0A05258p 437155 8290490 KLTH0A05258g Lachancea thermotolerans CBS 6340 KLTH0A05258p XP_002551686.1 436670 D 559295 CDS KLTH0A05280g 255710807 8290491 complement(437543..439168) 1 NC_013077.1 highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix; KLTH0A05280p 439168 8290491 KLTH0A05280g Lachancea thermotolerans CBS 6340 KLTH0A05280p XP_002551687.1 437543 R 559295 CDS KLTH0A05302g 255710809 8290492 join(440041..440095,440159..440568) 1 NC_013077.1 similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C; KLTH0A05302p 440568 8290492 KLTH0A05302g Lachancea thermotolerans CBS 6340 KLTH0A05302p XP_002551688.1 440041 D 559295 CDS KLTH0A05324g 255710811 8290493 442339..444837 1 NC_013077.1 highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome; KLTH0A05324p 444837 8290493 KLTH0A05324g Lachancea thermotolerans CBS 6340 KLTH0A05324p XP_002551689.1 442339 D 559295 CDS KLTH0A05346g 255710813 8290494 complement(445174..446079) 1 NC_013077.1 similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin- dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth; KLTH0A05346p 446079 8290494 KLTH0A05346g Lachancea thermotolerans CBS 6340 KLTH0A05346p XP_002551690.1 445174 R 559295 CDS KLTH0A05368g 255710815 8290495 complement(446807..448030) 1 NC_013077.1 similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W; KLTH0A05368p 448030 8290495 KLTH0A05368g Lachancea thermotolerans CBS 6340 KLTH0A05368p XP_002551691.1 446807 R 559295 CDS KLTH0A05390g 255710817 8290496 complement(448483..449877) 1 NC_013077.1 weakly similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF; KLTH0A05390p 449877 8290496 KLTH0A05390g Lachancea thermotolerans CBS 6340 KLTH0A05390p XP_002551692.1 448483 R 559295 CDS KLTH0A05412g 255710819 8290497 complement(450284..450985) 1 NC_013077.1 weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF; KLTH0A05412p 450985 8290497 KLTH0A05412g Lachancea thermotolerans CBS 6340 KLTH0A05412p XP_002551693.1 450284 R 559295 CDS KLTH0A05434g 255710821 8290498 complement(join(451664..451870,452033..452146)) 1 NC_013077.1 highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component; KLTH0A05434p 452146 8290498 KLTH0A05434g Lachancea thermotolerans CBS 6340 KLTH0A05434p XP_002551694.1 451664 R 559295 CDS KLTH0A05456g 255710823 8290499 453736..454107 1 NC_013077.1 conserved hypothetical protein; KLTH0A05456p 454107 8290499 KLTH0A05456g Lachancea thermotolerans CBS 6340 KLTH0A05456p XP_002551695.1 453736 D 559295 CDS KLTH0A05478g 255710825 8290500 454908..458162 1 NC_013077.1 similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Hypothetical ORF; KLTH0A05478p 458162 8290500 KLTH0A05478g Lachancea thermotolerans CBS 6340 KLTH0A05478p XP_002551696.1 454908 D 559295 CDS KLTH0A05500g 255710827 8290501 complement(458289..458951) 1 NC_013077.1 similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p; KLTH0A05500p 458951 8290501 KLTH0A05500g Lachancea thermotolerans CBS 6340 KLTH0A05500p XP_002551697.1 458289 R 559295 CDS KLTH0A05522g 255710829 8290502 459409..459897 1 NC_013077.1 similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis; KLTH0A05522p 459897 8290502 KLTH0A05522g Lachancea thermotolerans CBS 6340 KLTH0A05522p XP_002551698.1 459409 D 559295 CDS KLTH0A05544g 255710831 8290503 460303..462198 1 NC_013077.1 weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule- mediated processes; required for sister chromatid cohesion; KLTH0A05544p 462198 8290503 KLTH0A05544g Lachancea thermotolerans CBS 6340 KLTH0A05544p XP_002551699.1 460303 D 559295 CDS KLTH0A05566g 255710833 8290504 complement(462287..463582) 1 NC_013077.1 similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase- coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions; KLTH0A05566p 463582 8290504 KLTH0A05566g Lachancea thermotolerans CBS 6340 KLTH0A05566p XP_002551700.1 462287 R 559295 CDS KLTH0A05588g 255710835 8290505 complement(463948..465078) 1 NC_013077.1 weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p; KLTH0A05588p 465078 8290505 KLTH0A05588g Lachancea thermotolerans CBS 6340 KLTH0A05588p XP_002551701.1 463948 R 559295 CDS KLTH0A05610g 255710837 8290506 465309..466430 1 NC_013077.1 conserved hypothetical protein; KLTH0A05610p 466430 8290506 KLTH0A05610g Lachancea thermotolerans CBS 6340 KLTH0A05610p XP_002551702.1 465309 D 559295 CDS KLTH0A05632g 255710839 8290507 467019..468533 1 NC_013077.1 similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START; G(sub)1 cyclin; KLTH0A05632p 468533 8290507 KLTH0A05632g Lachancea thermotolerans CBS 6340 KLTH0A05632p XP_002551703.1 467019 D 559295 CDS KLTH0A05654g 255710841 8290508 468827..469576 1 NC_013077.1 similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations; KLTH0A05654p 469576 8290508 KLTH0A05654g Lachancea thermotolerans CBS 6340 KLTH0A05654p XP_002551704.1 468827 D 559295 CDS KLTH0A05676g 255710843 8290509 469968..471845 1 NC_013077.1 similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function; KLTH0A05676p 471845 8290509 KLTH0A05676g Lachancea thermotolerans CBS 6340 KLTH0A05676p XP_002551705.1 469968 D 559295 CDS KLTH0A05698g 255710845 8290510 complement(join(472128..473150,473244..473270)) 1 NC_013077.1 similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein; KLTH0A05698p 473270 8290510 KLTH0A05698g Lachancea thermotolerans CBS 6340 KLTH0A05698p XP_002551706.1 472128 R 559295 CDS KLTH0A05720g 255710847 8290511 complement(473454..474338) 1 NC_013077.1 similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p- phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy; KLTH0A05720p 474338 8290511 KLTH0A05720g Lachancea thermotolerans CBS 6340 KLTH0A05720p XP_002551707.1 473454 R 559295 CDS KLTH0A05742g 255710849 8290512 474516..476417 1 NC_013077.1 similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase; KLTH0A05742p 476417 8290512 KLTH0A05742g Lachancea thermotolerans CBS 6340 KLTH0A05742p XP_002551708.1 474516 D 559295 CDS KLTH0A05764g 255710851 8290513 476615..477211 1 NC_013077.1 weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W Hypothetical ORF; KLTH0A05764p 477211 8290513 KLTH0A05764g Lachancea thermotolerans CBS 6340 KLTH0A05764p XP_002551709.1 476615 D 559295 CDS KLTH0A05786g 255710853 8290514 477538..478206 1 NC_013077.1 similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis; KLTH0A05786p 478206 8290514 KLTH0A05786g Lachancea thermotolerans CBS 6340 KLTH0A05786p XP_002551710.1 477538 D 559295 CDS KLTH0A05808g 255710855 8290515 478459..478818 1 NC_013077.1 some similarities with uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity; KLTH0A05808p 478818 8290515 KLTH0A05808g Lachancea thermotolerans CBS 6340 KLTH0A05808p XP_002551711.1 478459 D 559295 CDS KLTH0A05830g 255710857 8290516 479011..480180 1 NC_013077.1 highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore; KLTH0A05830p 480180 8290516 KLTH0A05830g Lachancea thermotolerans CBS 6340 KLTH0A05830p XP_002551712.1 479011 D 559295 CDS KLTH0A05852g 255710859 8290517 complement(480862..482028) 1 NC_013077.1 weakly similar to uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF; KLTH0A05852p 482028 8290517 KLTH0A05852g Lachancea thermotolerans CBS 6340 KLTH0A05852p XP_002551713.1 480862 R 559295 CDS KLTH0A05874g 255710861 8290518 complement(482307..485327) 1 NC_013077.1 highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6- bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes; KLTH0A05874p 485327 8290518 KLTH0A05874g Lachancea thermotolerans CBS 6340 KLTH0A05874p XP_002551714.1 482307 R 559295 CDS KLTH0A05896g 255710863 8290519 complement(486445..487485) 1 NC_013077.1 highly similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S- D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress; KLTH0A05896p 487485 8290519 KLTH0A05896g Lachancea thermotolerans CBS 6340 KLTH0A05896p XP_002551715.1 486445 R 559295 CDS KLTH0A05918g 255710865 8290520 complement(487673..490363) 1 NC_013077.1 similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing; KLTH0A05918p 490363 8290520 KLTH0A05918g Lachancea thermotolerans CBS 6340 KLTH0A05918p XP_002551716.1 487673 R 559295 CDS KLTH0A05940g 255710867 8290521 490562..492037 1 NC_013077.1 similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase; KLTH0A05940p 492037 8290521 KLTH0A05940g Lachancea thermotolerans CBS 6340 KLTH0A05940p XP_002551717.1 490562 D 559295 CDS KLTH0A05962g 255710869 8290522 complement(492119..494842) 1 NC_013077.1 similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth; KLTH0A05962p 494842 8290522 KLTH0A05962g Lachancea thermotolerans CBS 6340 KLTH0A05962p XP_002551718.1 492119 R 559295 CDS KLTH0A05984g 255710871 8290523 495293..495949 1 NC_013077.1 conserved hypothetical protein; KLTH0A05984p 495949 8290523 KLTH0A05984g Lachancea thermotolerans CBS 6340 KLTH0A05984p XP_002551719.1 495293 D 559295 CDS KLTH0A06006g 255710873 8290524 complement(496157..500506) 1 NC_013077.1 conserved hypothetical protein; KLTH0A06006p 500506 8290524 KLTH0A06006g Lachancea thermotolerans CBS 6340 KLTH0A06006p XP_002551720.1 496157 R 559295 CDS KLTH0A06028g 255710875 8290525 502053..503246 1 NC_013077.1 similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase; KLTH0A06028p 503246 8290525 KLTH0A06028g Lachancea thermotolerans CBS 6340 KLTH0A06028p XP_002551721.1 502053 D 559295 CDS KLTH0A06050g 255710877 8290526 complement(504244..510936) 1 NC_013077.1 highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids or YMR207C uniprot|P32874 Saccharomyces cerevisiae YMR207C HFA1 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; KLTH0A06050p 510936 8290526 KLTH0A06050g Lachancea thermotolerans CBS 6340 KLTH0A06050p XP_002551722.1 504244 R 559295 CDS KLTH0A06072g 255710879 8290527 512774..513424 1 NC_013077.1 similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system; KLTH0A06072p 513424 8290527 KLTH0A06072g Lachancea thermotolerans CBS 6340 KLTH0A06072p XP_002551723.1 512774 D 559295 CDS KLTH0A06094g 255710881 8290528 complement(513667..515157) 1 NC_013077.1 similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C Hypothetical ORF; KLTH0A06094p 515157 8290528 KLTH0A06094g Lachancea thermotolerans CBS 6340 KLTH0A06094p XP_002551724.1 513667 R 559295 CDS KLTH0A06138g 255710883 8290530 517260..517925 1 NC_013077.1 similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF; KLTH0A06138p 517925 8290530 KLTH0A06138g Lachancea thermotolerans CBS 6340 KLTH0A06138p XP_002551725.1 517260 D 559295 CDS KLTH0A06160g 255710885 8290531 complement(518116..518625) 1 NC_013077.1 similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome; KLTH0A06160p 518625 8290531 KLTH0A06160g Lachancea thermotolerans CBS 6340 KLTH0A06160p XP_002551726.1 518116 R 559295 CDS KLTH0A06182g 255710887 8290532 complement(518948..519754) 1 NC_013077.1 highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0A06182p 519754 8290532 KLTH0A06182g Lachancea thermotolerans CBS 6340 KLTH0A06182p XP_002551727.1 518948 R 559295 CDS KLTH0A06204g 255710889 8290533 521514..523202 1 NC_013077.1 similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; KLTH0A06204p 523202 8290533 KLTH0A06204g Lachancea thermotolerans CBS 6340 KLTH0A06204p XP_002551728.1 521514 D 559295 CDS KLTH0A06226g 255710891 8290534 complement(523293..524024) 1 NC_013077.1 similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF; KLTH0A06226p 524024 8290534 KLTH0A06226g Lachancea thermotolerans CBS 6340 KLTH0A06226p XP_002551729.1 523293 R 559295 CDS KLTH0A06248g 255710893 8290535 524183..524791 1 NC_013077.1 similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF; KLTH0A06248p 524791 8290535 KLTH0A06248g Lachancea thermotolerans CBS 6340 KLTH0A06248p XP_002551730.1 524183 D 559295 CDS KLTH0A06270g 255710895 8290536 525035..526264 1 NC_013077.1 similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF; KLTH0A06270p 526264 8290536 KLTH0A06270g Lachancea thermotolerans CBS 6340 KLTH0A06270p XP_002551731.1 525035 D 559295 CDS KLTH0A06292g 255710897 8290537 complement(526397..526825) 1 NC_013077.1 similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; KLTH0A06292p 526825 8290537 KLTH0A06292g Lachancea thermotolerans CBS 6340 KLTH0A06292p XP_002551732.1 526397 R 559295 CDS KLTH0A06314g 255710899 8290538 527454..528776 1 NC_013077.1 some similarities with uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex; KLTH0A06314p 528776 8290538 KLTH0A06314g Lachancea thermotolerans CBS 6340 KLTH0A06314p XP_002551733.1 527454 D 559295 CDS KLTH0A06336g 255710901 8290539 528991..530520 1 NC_013077.1 highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase; KLTH0A06336p 530520 8290539 KLTH0A06336g Lachancea thermotolerans CBS 6340 KLTH0A06336p XP_002551734.1 528991 D 559295 CDS KLTH0A06380g 255710903 8290541 complement(532367..535114) 1 NC_013077.1 highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein; KLTH0A06380p 535114 8290541 KLTH0A06380g Lachancea thermotolerans CBS 6340 KLTH0A06380p XP_002551735.1 532367 R 559295 CDS KLTH0A06402g 255710905 8290542 535357..535836 1 NC_013077.1 conserved hypothetical protein; KLTH0A06402p 535836 8290542 KLTH0A06402g Lachancea thermotolerans CBS 6340 KLTH0A06402p XP_002551736.1 535357 D 559295 CDS KLTH0A06424g 255710907 8290543 complement(535960..536772) 1 NC_013077.1 similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN); KLTH0A06424p 536772 8290543 KLTH0A06424g Lachancea thermotolerans CBS 6340 KLTH0A06424p XP_002551737.1 535960 R 559295 CDS KLTH0A06446g 255710909 8290544 538144..539985 1 NC_013077.1 similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0A06446p 539985 8290544 KLTH0A06446g Lachancea thermotolerans CBS 6340 KLTH0A06446p XP_002551738.1 538144 D 559295 CDS KLTH0A06468g 255710911 8290545 540882..541502 1 NC_013077.1 similar to uniprot|Q07923 Saccharomyces cerevisiae YLR011W LOT6 Putative NADPH-dependent FMN reductase with strong ferricyanide reductase activity in vitro gene expression increases in cultures shifted to a lower temperature; KLTH0A06468p 541502 8290545 KLTH0A06468g Lachancea thermotolerans CBS 6340 KLTH0A06468p XP_002551739.1 540882 D 559295 CDS KLTH0A06512g 255710913 8290547 542323..542790 1 NC_013077.1 highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0A06512p 542790 8290547 KLTH0A06512g Lachancea thermotolerans CBS 6340 KLTH0A06512p XP_002551740.1 542323 D 559295 CDS KLTH0A06534g 255710915 8290548 543130..544806 1 NC_013077.1 weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly; KLTH0A06534p 544806 8290548 KLTH0A06534g Lachancea thermotolerans CBS 6340 KLTH0A06534p XP_002551741.1 543130 D 559295 CDS KLTH0A06556g 255710917 8290549 545636..547018 1 NC_013077.1 similar to uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif; KLTH0A06556p 547018 8290549 KLTH0A06556g Lachancea thermotolerans CBS 6340 KLTH0A06556p XP_002551742.1 545636 D 559295 CDS KLTH0A06578g 255710919 8290550 complement(547101..550316) 1 NC_013077.1 similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p; KLTH0A06578p 550316 8290550 KLTH0A06578g Lachancea thermotolerans CBS 6340 KLTH0A06578p XP_002551743.1 547101 R 559295 CDS KLTH0A06600g 255710921 8290551 550407..551324 1 NC_013077.1 similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0A06600p 551324 8290551 KLTH0A06600g Lachancea thermotolerans CBS 6340 KLTH0A06600p XP_002551744.1 550407 D 559295 CDS KLTH0A06622g 255710923 8290552 551457..553004 1 NC_013077.1 similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; KLTH0A06622p 553004 8290552 KLTH0A06622g Lachancea thermotolerans CBS 6340 KLTH0A06622p XP_002551745.1 551457 D 559295 CDS KLTH0A06644g 255710925 8290553 complement(553084..555270) 1 NC_013077.1 conserved hypothetical protein; KLTH0A06644p 555270 8290553 KLTH0A06644g Lachancea thermotolerans CBS 6340 KLTH0A06644p XP_002551746.1 553084 R 559295 CDS KLTH0A06666g 255710927 8290554 556052..556993 1 NC_013077.1 similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway; KLTH0A06666p 556993 8290554 KLTH0A06666g Lachancea thermotolerans CBS 6340 KLTH0A06666p XP_002551747.1 556052 D 559295 CDS KLTH0A06688g 255710929 8290555 complement(557036..558268) 1 NC_013077.1 similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF; KLTH0A06688p 558268 8290555 KLTH0A06688g Lachancea thermotolerans CBS 6340 KLTH0A06688p XP_002551748.1 557036 R 559295 CDS KLTH0A06710g 255710931 8290556 558390..560036 1 NC_013077.1 similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation; KLTH0A06710p 560036 8290556 KLTH0A06710g Lachancea thermotolerans CBS 6340 KLTH0A06710p XP_002551749.1 558390 D 559295 CDS KLTH0A06732g 255710933 8290557 complement(560106..560624) 1 NC_013077.1 similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit; KLTH0A06732p 560624 8290557 KLTH0A06732g Lachancea thermotolerans CBS 6340 KLTH0A06732p XP_002551750.1 560106 R 559295 CDS KLTH0A06754g 255710935 8290558 complement(560921..562465) 1 NC_013077.1 highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability; KLTH0A06754p 562465 8290558 KLTH0A06754g Lachancea thermotolerans CBS 6340 KLTH0A06754p XP_002551751.1 560921 R 559295 CDS KLTH0A06776g 255710937 8290559 complement(562932..567503) 1 NC_013077.1 similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p; KLTH0A06776p 567503 8290559 KLTH0A06776g Lachancea thermotolerans CBS 6340 KLTH0A06776p XP_002551752.1 562932 R 559295 CDS KLTH0A06798g 255710939 8290560 567632..568699 1 NC_013077.1 highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases; KLTH0A06798p 568699 8290560 KLTH0A06798g Lachancea thermotolerans CBS 6340 KLTH0A06798p XP_002551753.1 567632 D 559295 CDS KLTH0A06820g 255710941 8290561 complement(569895..570116) 1 NC_013077.1 similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1; KLTH0A06820p 570116 8290561 KLTH0A06820g Lachancea thermotolerans CBS 6340 KLTH0A06820p XP_002551754.1 569895 R 559295 CDS KLTH0A06842g 255710943 8290562 570282..572528 1 NC_013077.1 similar to uniprot|Q6B1Q1 Saccharomyces cerevisiae YNR033W; KLTH0A06842p 572528 8290562 KLTH0A06842g Lachancea thermotolerans CBS 6340 KLTH0A06842p XP_002551755.1 570282 D 559295 CDS KLTH0A06864g 255710945 8290563 573655..574686 1 NC_013077.1 similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W; KLTH0A06864p 574686 8290563 KLTH0A06864g Lachancea thermotolerans CBS 6340 KLTH0A06864p XP_002551756.1 573655 D 559295 CDS KLTH0A06886g 255710947 8290564 complement(574848..575597) 1 NC_013077.1 similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C; KLTH0A06886p 575597 8290564 KLTH0A06886g Lachancea thermotolerans CBS 6340 KLTH0A06886p XP_002551757.1 574848 R 559295 CDS KLTH0A06908g 255710949 8290565 complement(575902..577665) 1 NC_013077.1 conserved hypothetical protein; KLTH0A06908p 577665 8290565 KLTH0A06908g Lachancea thermotolerans CBS 6340 KLTH0A06908p XP_002551758.1 575902 R 559295 CDS KLTH0A06930g 255710951 8290566 578040..578300 1 NC_013077.1 similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii; KLTH0A06930p 578300 8290566 KLTH0A06930g Lachancea thermotolerans CBS 6340 KLTH0A06930p XP_002551759.1 578040 D 559295 CDS KLTH0A06952g 255710953 8290567 complement(578369..579304) 1 NC_013077.1 conserved hypothetical protein; KLTH0A06952p 579304 8290567 KLTH0A06952g Lachancea thermotolerans CBS 6340 KLTH0A06952p XP_002551760.1 578369 R 559295 CDS KLTH0A06974g 255710955 8290568 complement(579496..582102) 1 NC_013077.1 similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation- dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p; KLTH0A06974p 582102 8290568 KLTH0A06974g Lachancea thermotolerans CBS 6340 KLTH0A06974p XP_002551761.1 579496 R 559295 CDS KLTH0A06996g 255710957 8290569 complement(582435..583391) 1 NC_013077.1 similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin; KLTH0A06996p 583391 8290569 KLTH0A06996g Lachancea thermotolerans CBS 6340 KLTH0A06996p XP_002551762.1 582435 R 559295 CDS KLTH0A07018g 255710959 8290570 complement(583576..584091) 1 NC_013077.1 similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C; KLTH0A07018p 584091 8290570 KLTH0A07018g Lachancea thermotolerans CBS 6340 KLTH0A07018p XP_002551763.1 583576 R 559295 CDS KLTH0A07040g 255710961 8290571 585536..586978 1 NC_013077.1 similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF; KLTH0A07040p 586978 8290571 KLTH0A07040g Lachancea thermotolerans CBS 6340 KLTH0A07040p XP_002551764.1 585536 D 559295 CDS KLTH0A07062g 255710963 8290572 complement(587250..587525) 1 NC_013077.1 highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C; KLTH0A07062p 587525 8290572 KLTH0A07062g Lachancea thermotolerans CBS 6340 KLTH0A07062p XP_002551765.1 587250 R 559295 CDS KLTH0A07084g 255710965 8290573 587692..589578 1 NC_013077.1 similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD- box protein family; KLTH0A07084p 589578 8290573 KLTH0A07084g Lachancea thermotolerans CBS 6340 KLTH0A07084p XP_002551766.1 587692 D 559295 CDS KLTH0A07106g 255710967 8290574 589774..593877 1 NC_013077.1 similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit; KLTH0A07106p 593877 8290574 KLTH0A07106g Lachancea thermotolerans CBS 6340 KLTH0A07106p XP_002551767.1 589774 D 559295 CDS KLTH0A07128g 255710969 8290575 complement(594164..595864) 1 NC_013077.1 similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc; KLTH0A07128p 595864 8290575 KLTH0A07128g Lachancea thermotolerans CBS 6340 KLTH0A07128p XP_002551768.1 594164 R 559295 CDS KLTH0A07150g 255710971 8290576 596361..597467 1 NC_013077.1 similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; KLTH0A07150p 597467 8290576 KLTH0A07150g Lachancea thermotolerans CBS 6340 KLTH0A07150p XP_002551769.1 596361 D 559295 CDS KLTH0A07172g 255710973 8290577 complement(597528..598358) 1 NC_013077.1 weakly similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF; KLTH0A07172p 598358 8290577 KLTH0A07172g Lachancea thermotolerans CBS 6340 KLTH0A07172p XP_002551770.1 597528 R 559295 CDS KLTH0A07194g 255710975 8290578 complement(598542..598940) 1 NC_013077.1 some similarities with uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 mitochondrial thioredoxin; KLTH0A07194p 598940 8290578 KLTH0A07194g Lachancea thermotolerans CBS 6340 KLTH0A07194p XP_002551771.1 598542 R 559295 CDS KLTH0A07216g 255710977 8290579 complement(599149..599559) 1 NC_013077.1 weakly similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 component of the yeast ADA acetyltransferase complex; KLTH0A07216p 599559 8290579 KLTH0A07216g Lachancea thermotolerans CBS 6340 KLTH0A07216p XP_002551772.1 599149 R 559295 CDS KLTH0A07238g 255710979 8290580 join(600411..600455,600564..601712) 1 NC_013077.1 similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer; KLTH0A07238p 601712 8290580 KLTH0A07238g Lachancea thermotolerans CBS 6340 KLTH0A07238p XP_002551773.1 600411 D 559295 CDS KLTH0A07260g 255710981 8290581 602127..604328 1 NC_013077.1 weakly similar to uniprot|P35995 Saccharomyces cerevisiae YKL222c; KLTH0A07260p 604328 8290581 KLTH0A07260g Lachancea thermotolerans CBS 6340 KLTH0A07260p XP_002551774.1 602127 D 559295 CDS KLTH0A07282g 255710983 8290582 complement(604949..607126) 1 NC_013077.1 some similarities with uniprot|P18323 Saccharomyces cerevisiae YCR084C; KLTH0A07282p 607126 8290582 KLTH0A07282g Lachancea thermotolerans CBS 6340 KLTH0A07282p XP_002551775.1 604949 R 559295 CDS KLTH0A07304g 255710985 8290583 607568..608095 1 NC_013077.1 similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication; KLTH0A07304p 608095 8290583 KLTH0A07304g Lachancea thermotolerans CBS 6340 KLTH0A07304p XP_002551776.1 607568 D 559295 CDS KLTH0A07326g 255710987 8290584 complement(608380..608883) 1 NC_013077.1 similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF; KLTH0A07326p 608883 8290584 KLTH0A07326g Lachancea thermotolerans CBS 6340 KLTH0A07326p XP_002551777.1 608380 R 559295 CDS KLTH0A07348g 255710989 8290585 610049..611929 1 NC_013077.1 similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; KLTH0A07348p 611929 8290585 KLTH0A07348g Lachancea thermotolerans CBS 6340 KLTH0A07348p XP_002551778.1 610049 D 559295 CDS KLTH0A07370g 255710991 8290586 612403..616227 1 NC_013077.1 some similarities with uniprot|P25653 Saccharomyces cerevisiae YCR089W FIG2 Cell wall adhesin expressed specifically during mating may be involved in maintenance of cell wall integrity during mating; KLTH0A07370p 616227 8290586 KLTH0A07370g Lachancea thermotolerans CBS 6340 KLTH0A07370p XP_002551779.1 612403 D 559295 CDS KLTH0A07392g 255710993 8290587 complement(616307..616864) 1 NC_013077.1 similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF; KLTH0A07392p 616864 8290587 KLTH0A07392g Lachancea thermotolerans CBS 6340 KLTH0A07392p XP_002551780.1 616307 R 559295 CDS KLTH0A07414g 255710995 8290588 617043..618317 1 NC_013077.1 weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane; KLTH0A07414p 618317 8290588 KLTH0A07414g Lachancea thermotolerans CBS 6340 KLTH0A07414p XP_002551781.1 617043 D 559295 CDS KLTH0A07436g 255710997 8290589 618523..618924 1 NC_013077.1 highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability; KLTH0A07436p 618924 8290589 KLTH0A07436g Lachancea thermotolerans CBS 6340 KLTH0A07436p XP_002551782.1 618523 D 559295 CDS KLTH0A07458g 255710999 8290590 620459..623080 1 NC_013077.1 similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate; KLTH0A07458p 623080 8290590 KLTH0A07458g Lachancea thermotolerans CBS 6340 KLTH0A07458p XP_002551783.1 620459 D 559295 CDS KLTH0A07480g 255711001 8290591 complement(623145..626252) 1 NC_013077.1 similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability; KLTH0A07480p 626252 8290591 KLTH0A07480g Lachancea thermotolerans CBS 6340 KLTH0A07480p XP_002551784.1 623145 R 559295 CDS KLTH0A07502g 255711003 8290592 627176..633685 1 NC_013077.1 some similarities with uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels; KLTH0A07502p 633685 8290592 KLTH0A07502g Lachancea thermotolerans CBS 6340 KLTH0A07502p XP_002551785.1 627176 D 559295 CDS KLTH0A07524g 255711005 8290593 634227..635408 1 NC_013077.1 similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity; KLTH0A07524p 635408 8290593 KLTH0A07524g Lachancea thermotolerans CBS 6340 KLTH0A07524p XP_002551786.1 634227 D 559295 CDS KLTH0A07546g 255711007 8290594 635570..636217 1 NC_013077.1 highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER- associated protein degradation (ERAD) component of the cellular stress response; KLTH0A07546p 636217 8290594 KLTH0A07546g Lachancea thermotolerans CBS 6340 KLTH0A07546p XP_002551787.1 635570 D 559295 CDS KLTH0A07568g 255711009 8290595 complement(638520..639071) 1 NC_013077.1 weakly similar to uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation; KLTH0A07568p 639071 8290595 KLTH0A07568g Lachancea thermotolerans CBS 6340 KLTH0A07568p XP_002551788.1 638520 R 559295 CDS KLTH0A07590g 255711011 8290596 complement(639228..640568) 1 NC_013077.1 highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming); KLTH0A07590p 640568 8290596 KLTH0A07590g Lachancea thermotolerans CBS 6340 KLTH0A07590p XP_002551789.1 639228 R 559295 CDS KLTH0A07612g 255711013 8290597 complement(join(641201..642153,642217..642262)) 1 NC_013077.1 similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; KLTH0A07612p 642262 8290597 KLTH0A07612g Lachancea thermotolerans CBS 6340 KLTH0A07612p XP_002551790.1 641201 R 559295 CDS KLTH0A07634g 255711015 8290598 complement(642477..643940) 1 NC_013077.1 similar to uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor; KLTH0A07634p 643940 8290598 KLTH0A07634g Lachancea thermotolerans CBS 6340 KLTH0A07634p XP_002551791.1 642477 R 559295 CDS KLTH0A07656g 255711017 8290599 complement(644272..645540) 1 NC_013077.1 weakly similar to uniprot|P39008 Saccharomyces cerevisiae YNR052C POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; KLTH0A07656p 645540 8290599 KLTH0A07656g Lachancea thermotolerans CBS 6340 KLTH0A07656p XP_002551792.1 644272 R 559295 CDS KLTH0A07678g 255711019 8290600 complement(join(645874..646572,646994..647803)) 1 NC_013077.1 some similarities with uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; KLTH0A07678p 647803 8290600 KLTH0A07678g Lachancea thermotolerans CBS 6340 KLTH0A07678p XP_002551793.1 645874 R 559295 CDS KLTH0A07700g 255711021 8290601 complement(647969..648877) 1 NC_013077.1 similar to uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing; KLTH0A07700p 648877 8290601 KLTH0A07700g Lachancea thermotolerans CBS 6340 KLTH0A07700p XP_002551794.1 647969 R 559295 CDS KLTH0A07722g 255711023 8290602 650427..651605 1 NC_013077.1 similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor; KLTH0A07722p 651605 8290602 KLTH0A07722g Lachancea thermotolerans CBS 6340 KLTH0A07722p XP_002551795.1 650427 D 559295 CDS KLTH0A07744g 255711025 8290603 652578..653339 1 NC_013077.1 similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C Hypothetical ORF; KLTH0A07744p 653339 8290603 KLTH0A07744g Lachancea thermotolerans CBS 6340 KLTH0A07744p XP_002551796.1 652578 D 559295 CDS KLTH0A07766g 255711027 8290604 654163..655980 1 NC_013077.1 conserved hypothetical protein; KLTH0A07766p 655980 8290604 KLTH0A07766g Lachancea thermotolerans CBS 6340 KLTH0A07766p XP_002551797.1 654163 D 559295 CDS KLTH0A07810g 255711029 8290606 complement(657742..659067) 1 NC_013077.1 highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF; KLTH0A07810p 659067 8290606 KLTH0A07810g Lachancea thermotolerans CBS 6340 KLTH0A07810p XP_002551798.1 657742 R 559295 CDS KLTH0A07832g 255711031 8290607 complement(660003..661517) 1 NC_013077.1 weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression; KLTH0A07832p 661517 8290607 KLTH0A07832g Lachancea thermotolerans CBS 6340 KLTH0A07832p XP_002551799.1 660003 R 559295 CDS KLTH0A07964g 255711033 8290613 complement(670591..672450) 1 NC_013077.1 similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C; KLTH0A07964p 672450 8290613 KLTH0A07964g Lachancea thermotolerans CBS 6340 KLTH0A07964p XP_002551800.1 670591 R 559295 CDS KLTH0A07986g 255711035 8290614 complement(678392..679639) 1 NC_013077.1 similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF; KLTH0A07986p 679639 8290614 KLTH0A07986g Lachancea thermotolerans CBS 6340 KLTH0A07986p XP_002551801.1 678392 R 559295 CDS KLTH0A08008g 255711037 8290615 681796..682542 1 NC_013077.1 conserved hypothetical protein; KLTH0A08008p 682542 8290615 KLTH0A08008g Lachancea thermotolerans CBS 6340 KLTH0A08008p XP_002551802.1 681796 D 559295 CDS KLTH0A08052g 255711039 8290617 complement(685177..686193) 1 NC_013077.1 highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; KLTH0A08052p 686193 8290617 KLTH0A08052g Lachancea thermotolerans CBS 6340 KLTH0A08052p XP_002551803.1 685177 R 559295 CDS KLTH0B00110g 255711042 8290621 complement(1655..3538) 1 NC_013078.1 similar to uniprot|P25596 Saccharomyces cerevisiae YCL073C and similar to uniprot|P36173 Saccharomyces cerevisiae YKR106W; KLTH0B00110p 3538 8290621 KLTH0B00110g Lachancea thermotolerans CBS 6340 KLTH0B00110p XP_002551804.1 1655 R 559295 CDS KLTH0B00132g 255711044 8290622 4664..6370 1 NC_013078.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF; KLTH0B00132p 6370 8290622 KLTH0B00132g Lachancea thermotolerans CBS 6340 KLTH0B00132p XP_002551805.1 4664 D 559295 CDS KLTH0B00154g 255711046 8290623 complement(7385..9055) 1 NC_013078.1 weakly similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease; KLTH0B00154p 9055 8290623 KLTH0B00154g Lachancea thermotolerans CBS 6340 KLTH0B00154p XP_002551806.1 7385 R 559295 CDS KLTH0B00176g 255711048 8290624 10791..12137 1 NC_013078.1 similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF; KLTH0B00176p 12137 8290624 KLTH0B00176g Lachancea thermotolerans CBS 6340 KLTH0B00176p XP_002551807.1 10791 D 559295 CDS KLTH0B00220g 255711050 8290626 complement(17460..18851) 1 NC_013078.1 highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive; KLTH0B00220p 18851 8290626 KLTH0B00220g Lachancea thermotolerans CBS 6340 KLTH0B00220p XP_002551808.1 17460 R 559295 CDS KLTH0B00264g 255711052 8290628 23546..24871 1 NC_013078.1 highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF; KLTH0B00264p 24871 8290628 KLTH0B00264g Lachancea thermotolerans CBS 6340 KLTH0B00264p XP_002551809.1 23546 D 559295 CDS KLTH0B00286g 255711054 8290629 25467..26243 1 NC_013078.1 similar to uniprot|Q12288 Saccharomyces cerevisiae YLR126C Hypothetical ORF; KLTH0B00286p 26243 8290629 KLTH0B00286g Lachancea thermotolerans CBS 6340 KLTH0B00286p XP_002551810.1 25467 D 559295 CDS KLTH0B00308g 255711056 8290630 complement(26947..28719) 1 NC_013078.1 highly similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C Hypothetical ORF; KLTH0B00308p 28719 8290630 KLTH0B00308g Lachancea thermotolerans CBS 6340 KLTH0B00308p XP_002551811.1 26947 R 559295 CDS KLTH0B00330g 255711058 8290631 29891..31591 1 NC_013078.1 highly similar to uniprot|P54862 Saccharomyces cerevisiae YOL156W HXT11 Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance; KLTH0B00330p 31591 8290631 KLTH0B00330g Lachancea thermotolerans CBS 6340 KLTH0B00330p XP_002551812.1 29891 D 559295 CDS KLTH0B00352g 255711060 8290632 complement(31952..34756) 1 NC_013078.1 weakly similar to uniprot|P25611 Saccharomyces cerevisiae YCR106W RDS1 Regulator of drug sensitivity transcriptional regulator; KLTH0B00352p 34756 8290632 KLTH0B00352g Lachancea thermotolerans CBS 6340 KLTH0B00352p XP_002551813.1 31952 R 559295 CDS KLTH0B00374g 255711062 8290633 complement(36075..37979) 1 NC_013078.1 similar to uniprot|Q08989 Saccharomyces cerevisiae YPL277C Hypothetical ORFs; KLTH0B00374p 37979 8290633 KLTH0B00374g Lachancea thermotolerans CBS 6340 KLTH0B00374p XP_002551814.1 36075 R 559295 CDS KLTH0B00396g 255711064 8290634 complement(38234..42757) 1 NC_013078.1 similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C; KLTH0B00396p 42757 8290634 KLTH0B00396g Lachancea thermotolerans CBS 6340 KLTH0B00396p XP_002551815.1 38234 R 559295 CDS KLTH0B00418g 255711066 8290635 complement(44522..46297) 1 NC_013078.1 highly similar to uniprot|P43550 Saccharomyces cerevisiae YFL053W DAK2 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation; KLTH0B00418p 46297 8290635 KLTH0B00418g Lachancea thermotolerans CBS 6340 KLTH0B00418p XP_002551816.1 44522 R 559295 CDS KLTH0B00440g 255711068 8290636 46950..48908 1 NC_013078.1 similar to uniprot|P43549 Saccharomyces cerevisiae YFL054C Hypothetical ORF; KLTH0B00440p 48908 8290636 KLTH0B00440g Lachancea thermotolerans CBS 6340 KLTH0B00440p XP_002551817.1 46950 D 559295 CDS KLTH0B00462g 255711070 8290637 complement(49413..51011) 1 NC_013078.1 weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins; KLTH0B00462p 51011 8290637 KLTH0B00462g Lachancea thermotolerans CBS 6340 KLTH0B00462p XP_002551818.1 49413 R 559295 CDS KLTH0B00484g 255711072 8290638 complement(51712..53412) 1 NC_013078.1 weakly similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor; KLTH0B00484p 53412 8290638 KLTH0B00484g Lachancea thermotolerans CBS 6340 KLTH0B00484p XP_002551819.1 51712 R 559295 CDS KLTH0B00506g 255711074 8290639 complement(53662..54858) 1 NC_013078.1 weakly similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C; KLTH0B00506p 54858 8290639 KLTH0B00506g Lachancea thermotolerans CBS 6340 KLTH0B00506p XP_002551820.1 53662 R 559295 CDS KLTH0B00528g 255711076 8290640 55345..56889 1 NC_013078.1 conserved hypothetical protein; KLTH0B00528p 56889 8290640 KLTH0B00528g Lachancea thermotolerans CBS 6340 KLTH0B00528p XP_002551821.1 55345 D 559295 CDS KLTH0B00550g 255711078 8290641 complement(57160..59163) 1 NC_013078.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; KLTH0B00550p 59163 8290641 KLTH0B00550g Lachancea thermotolerans CBS 6340 KLTH0B00550p XP_002551822.1 57160 R 559295 CDS KLTH0B00572g 255711080 8290642 complement(60243..61859) 1 NC_013078.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF; KLTH0B00572p 61859 8290642 KLTH0B00572g Lachancea thermotolerans CBS 6340 KLTH0B00572p XP_002551823.1 60243 R 559295 CDS KLTH0B00594g 255711082 8290643 64332..66188 1 NC_013078.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF; KLTH0B00594p 66188 8290643 KLTH0B00594g Lachancea thermotolerans CBS 6340 KLTH0B00594p XP_002551824.1 64332 D 559295 CDS KLTH0B00616g 255711084 8290644 complement(66965..67327) 1 NC_013078.1 no similarity; KLTH0B00616p 67327 8290644 KLTH0B00616g Lachancea thermotolerans CBS 6340 KLTH0B00616p XP_002551825.1 66965 R 559295 CDS KLTH0B00704g 255711086 8290648 complement(69489..69854) 1 NC_013078.1 no similarity; KLTH0B00704p 69854 8290648 KLTH0B00704g Lachancea thermotolerans CBS 6340 KLTH0B00704p XP_002551826.1 69489 R 559295 CDS KLTH0B00770g 255711088 8290651 complement(71519..71890) 1 NC_013078.1 no similarity; KLTH0B00770p 71890 8290651 KLTH0B00770g Lachancea thermotolerans CBS 6340 KLTH0B00770p XP_002551827.1 71519 R 559295 CDS KLTH0B00836g 255711090 8290654 73357..74829 1 NC_013078.1 conserved hypothetical protein; KLTH0B00836p 74829 8290654 KLTH0B00836g Lachancea thermotolerans CBS 6340 KLTH0B00836p XP_002551828.1 73357 D 559295 CDS KLTH0B00858g 255711092 8290655 75377..76294 1 NC_013078.1 highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions; KLTH0B00858p 76294 8290655 KLTH0B00858g Lachancea thermotolerans CBS 6340 KLTH0B00858p XP_002551829.1 75377 D 559295 CDS KLTH0B00880g 255711094 8290656 complement(76459..76767) 1 NC_013078.1 some similarities with uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus; KLTH0B00880p 76767 8290656 KLTH0B00880g Lachancea thermotolerans CBS 6340 KLTH0B00880p XP_002551830.1 76459 R 559295 CDS KLTH0B00902g 255711096 8290657 77624..78652 1 NC_013078.1 similar to uniprot|Q08913 Saccharomyces cerevisiae YOR390W Hypothetical ORF; KLTH0B00902p 78652 8290657 KLTH0B00902g Lachancea thermotolerans CBS 6340 KLTH0B00902p XP_002551831.1 77624 D 559295 CDS KLTH0B00924g 255711098 8290658 complement(79302..81446) 1 NC_013078.1 similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin- mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase; KLTH0B00924p 81446 8290658 KLTH0B00924g Lachancea thermotolerans CBS 6340 KLTH0B00924p XP_002551832.1 79302 R 559295 CDS KLTH0B00946g 255711100 8290659 81585..83456 1 NC_013078.1 similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion; KLTH0B00946p 83456 8290659 KLTH0B00946g Lachancea thermotolerans CBS 6340 KLTH0B00946p XP_002551833.1 81585 D 559295 CDS KLTH0B00968g 255711102 8290660 complement(83522..84985) 1 NC_013078.1 highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme); KLTH0B00968p 84985 8290660 KLTH0B00968g Lachancea thermotolerans CBS 6340 KLTH0B00968p XP_002551834.1 83522 R 559295 CDS KLTH0B00990g 255711104 8290661 86383..87597 1 NC_013078.1 similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; KLTH0B00990p 87597 8290661 KLTH0B00990g Lachancea thermotolerans CBS 6340 KLTH0B00990p XP_002551835.1 86383 D 559295 CDS KLTH0B01034g 255711106 8291090 complement(88067..89371) 1 NC_013078.1 similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1; KLTH0B01034p 89371 8291090 KLTH0B01034g Lachancea thermotolerans CBS 6340 KLTH0B01034p XP_002551836.1 88067 R 559295 CDS KLTH0B01056g 255711108 8290663 complement(89368..89970) 1 NC_013078.1 similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p; KLTH0B01056p 89970 8290663 KLTH0B01056g Lachancea thermotolerans CBS 6340 KLTH0B01056p XP_002551837.1 89368 R 559295 CDS KLTH0B01078g 255711110 8290664 91145..94192 1 NC_013078.1 highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability; KLTH0B01078p 94192 8290664 KLTH0B01078g Lachancea thermotolerans CBS 6340 KLTH0B01078p XP_002551838.1 91145 D 559295 CDS KLTH0B01100g 255711112 8290665 complement(94260..98156) 1 NC_013078.1 similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells; KLTH0B01100p 98156 8290665 KLTH0B01100g Lachancea thermotolerans CBS 6340 KLTH0B01100p XP_002551839.1 94260 R 559295 CDS KLTH0B01122g 255711114 8290666 98689..99342 1 NC_013078.1 similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene- fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis; KLTH0B01122p 99342 8290666 KLTH0B01122g Lachancea thermotolerans CBS 6340 KLTH0B01122p XP_002551840.1 98689 D 559295 CDS KLTH0B01144g 255711116 8290667 99614..100849 1 NC_013078.1 highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Hypothetical ORF; KLTH0B01144p 100849 8290667 KLTH0B01144g Lachancea thermotolerans CBS 6340 KLTH0B01144p XP_002551841.1 99614 D 559295 CDS KLTH0B01166g 255711118 8290668 102227..103960 1 NC_013078.1 similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease mediates high-affinity and high-capacity transport of L- glutamate and L-aspartate also a transporter for Gln Asn Ser Ala and Gly; KLTH0B01166p 103960 8290668 KLTH0B01166g Lachancea thermotolerans CBS 6340 KLTH0B01166p XP_002551842.1 102227 D 559295 CDS KLTH0B01188g 255711120 8290669 complement(104224..106005) 1 NC_013078.1 highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose- ethanol- and autoregulation involved in amino acid catabolism and to YLR134W uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism; KLTH0B01188p 106005 8290669 KLTH0B01188g Lachancea thermotolerans CBS 6340 KLTH0B01188p XP_002551843.1 104224 R 559295 CDS KLTH0B01210g 255711122 8290670 107203..108198 1 NC_013078.1 conserved hypothetical protein; KLTH0B01210p 108198 8290670 KLTH0B01210g Lachancea thermotolerans CBS 6340 KLTH0B01210p XP_002551844.1 107203 D 559295 CDS KLTH0B01232g 255711124 8290671 complement(108265..110865) 1 NC_013078.1 similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment interacts with spindle pole body component Spc72p; KLTH0B01232p 110865 8290671 KLTH0B01232g Lachancea thermotolerans CBS 6340 KLTH0B01232p XP_002551845.1 108265 R 559295 CDS KLTH0B01276g 255711126 8290673 112166..112477 1 NC_013078.1 similar to uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin; KLTH0B01276p 112477 8290673 KLTH0B01276g Lachancea thermotolerans CBS 6340 KLTH0B01276p XP_002551846.1 112166 D 559295 CDS KLTH0B01298g 255711128 8290674 complement(112541..113476) 1 NC_013078.1 similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 phosphoserine phosphatase; KLTH0B01298p 113476 8290674 KLTH0B01298g Lachancea thermotolerans CBS 6340 KLTH0B01298p XP_002551847.1 112541 R 559295 CDS KLTH0B01320g 255711130 8290675 113672..114448 1 NC_013078.1 highly similar to uniprot|P42940 YGR207C Saccharomyces cerevisiae YGR2 Hypothetical ORF; KLTH0B01320p 114448 8290675 KLTH0B01320g Lachancea thermotolerans CBS 6340 KLTH0B01320p XP_002551848.1 113672 D 559295 CDS KLTH0B01342g 255711132 8290676 complement(114503..114817) 1 NC_013078.1 similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W Hypothetical ORF; KLTH0B01342p 114817 8290676 KLTH0B01342g Lachancea thermotolerans CBS 6340 KLTH0B01342p XP_002551849.1 114503 R 559295 CDS KLTH0B01364g 255711134 8290677 115101..115676 1 NC_013078.1 highly similar to uniprot|P47096 Saccharomyces cerevisiae YJR025C BNA1 3-hydroxyanthranilic acid dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; KLTH0B01364p 115676 8290677 KLTH0B01364g Lachancea thermotolerans CBS 6340 KLTH0B01364p XP_002551850.1 115101 D 559295 CDS KLTH0B01386g 255711136 8290678 116004..116777 1 NC_013078.1 highly similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C Hypothetical ORF; KLTH0B01386p 116777 8290678 KLTH0B01386g Lachancea thermotolerans CBS 6340 KLTH0B01386p XP_002551851.1 116004 D 559295 CDS KLTH0B01408g 255711138 8290679 complement(116792..117124) 1 NC_013078.1 weakly similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing; KLTH0B01408p 117124 8290679 KLTH0B01408g Lachancea thermotolerans CBS 6340 KLTH0B01408p XP_002551852.1 116792 R 559295 CDS KLTH0B01452g 255711140 8290681 complement(118238..119137) 1 NC_013078.1 similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W Protein that binds ATP crystal structure resembles that of E.coli pantothenate kinase; KLTH0B01452p 119137 8290681 KLTH0B01452g Lachancea thermotolerans CBS 6340 KLTH0B01452p XP_002551853.1 118238 R 559295 CDS KLTH0B01474g 255711142 8290682 119312..120331 1 NC_013078.1 similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase; KLTH0B01474p 120331 8290682 KLTH0B01474g Lachancea thermotolerans CBS 6340 KLTH0B01474p XP_002551854.1 119312 D 559295 CDS KLTH0B01496g 255711144 8290683 complement(121140..123977) 1 NC_013078.1 similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1- tetrahydrofolate synthase involved in single carbon metabolism and required for biosynthesis of purines thymidylate methionine and histidine; KLTH0B01496p 123977 8290683 KLTH0B01496g Lachancea thermotolerans CBS 6340 KLTH0B01496p XP_002551855.1 121140 R 559295 CDS KLTH0B01518g 255711146 8290684 complement(124215..124559) 1 NC_013078.1 no similarity; KLTH0B01518p 124559 8290684 KLTH0B01518g Lachancea thermotolerans CBS 6340 KLTH0B01518p XP_002551856.1 124215 R 559295 CDS KLTH0B01540g 255711148 8290685 124955..125440 1 NC_013078.1 similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; KLTH0B01540p 125440 8290685 KLTH0B01540g Lachancea thermotolerans CBS 6340 KLTH0B01540p XP_002551857.1 124955 D 559295 CDS KLTH0B01562g 255711150 8290686 complement(125475..125924) 1 NC_013078.1 similar to uniprot|P42937 YGR203W Saccharomyces cerevisiae Probable protein tyrosine phosphatase of the CDC25-like phosphatase family; KLTH0B01562p 125924 8290686 KLTH0B01562g Lachancea thermotolerans CBS 6340 KLTH0B01562p XP_002551858.1 125475 R 559295 CDS KLTH0B01584g 255711152 8290687 126091..127368 1 NC_013078.1 weakly similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase; KLTH0B01584p 127368 8290687 KLTH0B01584g Lachancea thermotolerans CBS 6340 KLTH0B01584p XP_002551859.1 126091 D 559295 CDS KLTH0B01606g 255711154 8290688 127592..129364 1 NC_013078.1 highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; KLTH0B01606p 129364 8290688 KLTH0B01606g Lachancea thermotolerans CBS 6340 KLTH0B01606p XP_002551860.1 127592 D 559295 CDS KLTH0B01628g 255711156 8290689 129632..132004 1 NC_013078.1 similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Elongator protein part of the six- subunit RNA polymerase II Elongator histone acetyltransferase complex target of Kluyveromyces lactis zymocin; KLTH0B01628p 132004 8290689 KLTH0B01628g Lachancea thermotolerans CBS 6340 KLTH0B01628p XP_002551861.1 129632 D 559295 CDS KLTH0B01650g 255711158 8290690 complement(132053..134317) 1 NC_013078.1 similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase; KLTH0B01650p 134317 8290690 KLTH0B01650g Lachancea thermotolerans CBS 6340 KLTH0B01650p XP_002551862.1 132053 R 559295 CDS KLTH0B01672g 255711160 8290691 complement(134593..136791) 1 NC_013078.1 similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0B01672p 136791 8290691 KLTH0B01672g Lachancea thermotolerans CBS 6340 KLTH0B01672p XP_002551863.1 134593 R 559295 CDS KLTH0B01694g 255711162 8290692 complement(136942..137535) 1 NC_013078.1 similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W RBF22 Hypothetical ORF; KLTH0B01694p 137535 8290692 KLTH0B01694g Lachancea thermotolerans CBS 6340 KLTH0B01694p XP_002551864.1 136942 R 559295 CDS KLTH0B01716g 255711164 8290693 137755..140211 1 NC_013078.1 weakly similar to uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function required for survival upon exposure to K1 killer toxin; KLTH0B01716p 140211 8290693 KLTH0B01716g Lachancea thermotolerans CBS 6340 KLTH0B01716p XP_002551865.1 137755 D 559295 CDS KLTH0B01738g 255711166 8290694 complement(140265..141002) 1 NC_013078.1 highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 superkiller ExtraCellular Mutant Ribosomal RNA Processing homolog of RNAse PH; KLTH0B01738p 141002 8290694 KLTH0B01738g Lachancea thermotolerans CBS 6340 KLTH0B01738p XP_002551866.1 140265 R 559295 CDS KLTH0B01760g 255711168 8290695 complement(141964..143148) 1 NC_013078.1 similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol- alpha 1 4 mannosyltransferase I involved in GPI anchor biosynthesis requires Pbn1p for function homolog of mammalian PIG-M; KLTH0B01760p 143148 8290695 KLTH0B01760g Lachancea thermotolerans CBS 6340 KLTH0B01760p XP_002551867.1 141964 R 559295 CDS KLTH0B01782g 255711170 8290696 143331..143672 1 NC_013078.1 some similarities with uniprot|P47087 Saccharomyces cerevisiae YJR012C Protein required for cell viability; KLTH0B01782p 143672 8290696 KLTH0B01782g Lachancea thermotolerans CBS 6340 KLTH0B01782p XP_002551868.1 143331 D 559295 CDS KLTH0B01804g 255711172 8290697 complement(143910..144818) 1 NC_013078.1 weakly similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W YMC2 Putative mitochondrial inner membrane transporter, member of the mitochondrial carrier (MCF) family; KLTH0B01804p 144818 8290697 KLTH0B01804g Lachancea thermotolerans CBS 6340 KLTH0B01804p XP_002551869.1 143910 R 559295 CDS KLTH0B01826g 255711174 8290698 145103..145798 1 NC_013078.1 some similarities with uniprot|P47086 Saccharomyces cerevisiae YJR011C Hypothetical ORF; KLTH0B01826p 145798 8290698 KLTH0B01826g Lachancea thermotolerans CBS 6340 KLTH0B01826p XP_002551870.1 145103 D 559295 CDS KLTH0B01848g 255711176 8290699 146051..146317 1 NC_013078.1 similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A SPC1 Subunit of the signal peptidase complex (SPC) which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER) homolog of the SPC12 subunit of mammalian signal peptidase complex; KLTH0B01848p 146317 8290699 KLTH0B01848g Lachancea thermotolerans CBS 6340 KLTH0B01848p XP_002551871.1 146051 D 559295 CDS KLTH0B01870g 255711178 8290700 146628..148373 1 NC_013078.1 similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 third enzyme in the xylose pathway; Xylulokinase; KLTH0B01870p 148373 8290700 KLTH0B01870g Lachancea thermotolerans CBS 6340 KLTH0B01870p XP_002551872.1 146628 D 559295 CDS KLTH0B01892g 255711180 8290701 148776..150023 1 NC_013078.1 similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core; KLTH0B01892p 150023 8290701 KLTH0B01892g Lachancea thermotolerans CBS 6340 KLTH0B01892p XP_002551873.1 148776 D 559295 CDS KLTH0B01914g 255711182 8290702 complement(150142..151659) 1 NC_013078.1 highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase catalyzes the primary step of intracellular sulfate activation essential for assimilatory reduction of sulfate to sulfide involved in methionine metabolism; KLTH0B01914p 151659 8290702 KLTH0B01914g Lachancea thermotolerans CBS 6340 KLTH0B01914p XP_002551874.1 150142 R 559295 CDS KLTH0B01936g 255711184 8290703 complement(152392..153252) 1 NC_013078.1 similar to uniprot|P38892 Saccharomyces cerevisiae YHR209W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0B01936p 153252 8290703 KLTH0B01936g Lachancea thermotolerans CBS 6340 KLTH0B01936p XP_002551875.1 152392 R 559295 CDS KLTH0B01958g 255711186 8290704 154881..155879 1 NC_013078.1 highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases; KLTH0B01958p 155879 8290704 KLTH0B01958g Lachancea thermotolerans CBS 6340 KLTH0B01958p XP_002551876.1 154881 D 559295 CDS KLTH0B01980g 255711188 8290705 complement(156072..157040) 1 NC_013078.1 similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W Hypothetical ORF; KLTH0B01980p 157040 8290705 KLTH0B01980g Lachancea thermotolerans CBS 6340 KLTH0B01980p XP_002551877.1 156072 R 559295 CDS KLTH0B02002g 255711190 8290706 complement(157328..158236) 1 NC_013078.1 highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 involved in the identification of the start codon phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; KLTH0B02002p 158236 8290706 KLTH0B02002g Lachancea thermotolerans CBS 6340 KLTH0B02002p XP_002551878.1 157328 R 559295 CDS KLTH0B02024g 255711192 8290707 complement(158779..163020) 1 NC_013078.1 conserved hypothetical protein; KLTH0B02024p 163020 8290707 KLTH0B02024g Lachancea thermotolerans CBS 6340 KLTH0B02024p XP_002551879.1 158779 R 559295 CDS KLTH0B02046g 255711194 8290708 complement(163199..164968) 1 NC_013078.1 similar to uniprot|P06775 Saccharomyces cerevisiae YGR191W HIP1 High-affinity histidine permease also involved in the transport of manganese ions; KLTH0B02046p 164968 8290708 KLTH0B02046g Lachancea thermotolerans CBS 6340 KLTH0B02046p XP_002551880.1 163199 R 559295 CDS KLTH0B02090g 255711196 8290710 166400..167779 1 NC_013078.1 highly similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Putative glycosidase of the cell wall may have a role in cell wall architecture; KLTH0B02090p 167779 8290710 KLTH0B02090g Lachancea thermotolerans CBS 6340 KLTH0B02090p XP_002551881.1 166400 D 559295 CDS KLTH0B02134g 255711198 8290712 168159..168626 1 NC_013078.1 similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17 physically interacts with C31 C11 and TFIIIB70 may be involved in the recruitment of pol III by the preinitiation complex; KLTH0B02134p 168626 8290712 KLTH0B02134g Lachancea thermotolerans CBS 6340 KLTH0B02134p XP_002551882.1 168159 D 559295 CDS KLTH0B02156g 255711200 8290713 169117..171258 1 NC_013078.1 highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative); KLTH0B02156p 171258 8290713 KLTH0B02156g Lachancea thermotolerans CBS 6340 KLTH0B02156p XP_002551883.1 169117 D 559295 CDS KLTH0B02178g 255711202 8290714 171582..174551 1 NC_013078.1 similar to uniprot|P41695 Saccharomyces cerevisiae YGR188C BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage associates with centromere DNA via Skp1p; KLTH0B02178p 174551 8290714 KLTH0B02178g Lachancea thermotolerans CBS 6340 KLTH0B02178p XP_002551884.1 171582 D 559295 CDS KLTH0B02200g 255711204 8290715 complement(174660..176267) 1 NC_013078.1 highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0B02200p 176267 8290715 KLTH0B02200g Lachancea thermotolerans CBS 6340 KLTH0B02200p XP_002551885.1 174660 R 559295 CDS KLTH0B02222g 255711206 8290716 complement(176446..178038) 1 NC_013078.1 weakly similar to uniprot|P47072 Saccharomyces cerevisiae YJL016W; KLTH0B02222p 178038 8290716 KLTH0B02222g Lachancea thermotolerans CBS 6340 KLTH0B02222p XP_002551886.1 176446 R 559295 CDS KLTH0B02244g 255711208 8290717 complement(178507..180393) 1 NC_013078.1 weakly similar to uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion localizes to the spindle pole body half bridge interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p; KLTH0B02244p 180393 8290717 KLTH0B02244g Lachancea thermotolerans CBS 6340 KLTH0B02244p XP_002551887.1 178507 R 559295 CDS KLTH0B02266g 255711210 8290718 join(180934..181515,181757..182203) 1 NC_013078.1 similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit; KLTH0B02266p 182203 8290718 KLTH0B02266g Lachancea thermotolerans CBS 6340 KLTH0B02266p XP_002551888.1 180934 D 559295 CDS KLTH0B02288g 255711212 8290719 182351..183724 1 NC_013078.1 similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W KRE11 Protein involved in biosynthesis of cell wall beta-glucans subunit of the TRAPP (transport protein particle) complex which is involved in the late steps of endoplasmic reticulum to Golgi transport; KLTH0B02288p 183724 8290719 KLTH0B02288g Lachancea thermotolerans CBS 6340 KLTH0B02288p XP_002551889.1 182351 D 559295 CDS KLTH0B02310g 255711214 8290720 184055..184708 1 NC_013078.1 similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain; KLTH0B02310p 184708 8290720 KLTH0B02310g Lachancea thermotolerans CBS 6340 KLTH0B02310p XP_002551890.1 184055 D 559295 CDS KLTH0B02332g 255711216 8290721 complement(184844..185872) 1 NC_013078.1 weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Hypothetical ORF; KLTH0B02332p 185872 8290721 KLTH0B02332g Lachancea thermotolerans CBS 6340 KLTH0B02332p XP_002551891.1 184844 R 559295 CDS KLTH0B02354g 255711218 8290722 186128..189772 1 NC_013078.1 weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p localized predominantly to cortical actin patches; KLTH0B02354p 189772 8290722 KLTH0B02354g Lachancea thermotolerans CBS 6340 KLTH0B02354p XP_002551892.1 186128 D 559295 CDS KLTH0B02376g 255711220 8290723 complement(189853..191046) 1 NC_013078.1 similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 RNA:Psi-synthase; KLTH0B02376p 191046 8290723 KLTH0B02376g Lachancea thermotolerans CBS 6340 KLTH0B02376p XP_002551893.1 189853 R 559295 CDS KLTH0B02398g 255711222 8290724 191249..192256 1 NC_013078.1 weakly similar to uniprot|P47065 Saccharomyces cerevisiae YJL023C PET130 Protein required for respiratory growth; KLTH0B02398p 192256 8290724 KLTH0B02398g Lachancea thermotolerans CBS 6340 KLTH0B02398p XP_002551894.1 191249 D 559295 CDS KLTH0B02420g 255711224 8290725 complement(192399..192665) 1 NC_013078.1 some similarities with uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A; KLTH0B02420p 192665 8290725 KLTH0B02420g Lachancea thermotolerans CBS 6340 KLTH0B02420p XP_002551895.1 192399 R 559295 CDS KLTH0B02442g 255711226 8290726 193387..196533 1 NC_013078.1 similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes converts phosphatidylserine to phosphatidylethanolamine; KLTH0B02442p 196533 8290726 KLTH0B02442g Lachancea thermotolerans CBS 6340 KLTH0B02442p XP_002551896.1 193387 D 559295 CDS KLTH0B02464g 255711228 8290727 join(196583..196677,196756..198121) 1 NC_013078.1 similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W HYS2 DNA polymerase III (delta) 55 kDa subunit essential for cell viability involved in DNA replication and DNA repair; KLTH0B02464p 198121 8290727 KLTH0B02464g Lachancea thermotolerans CBS 6340 KLTH0B02464p XP_002551897.1 196583 D 559295 CDS KLTH0B02486g 255711230 8290728 complement(198167..200032) 1 NC_013078.1 similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p; KLTH0B02486p 200032 8290728 KLTH0B02486g Lachancea thermotolerans CBS 6340 KLTH0B02486p XP_002551898.1 198167 R 559295 CDS KLTH0B02508g 255711232 8290729 complement(200122..200841) 1 NC_013078.1 similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Golgi integral membrane protein binds to the transport GTPases Ypt1p and Ypt31p; KLTH0B02508p 200841 8290729 KLTH0B02508g Lachancea thermotolerans CBS 6340 KLTH0B02508p XP_002551899.1 200122 R 559295 CDS KLTH0B02530g 255711234 8290730 201208..202314 1 NC_013078.1 highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W; KLTH0B02530p 202314 8290730 KLTH0B02530g Lachancea thermotolerans CBS 6340 KLTH0B02530p XP_002551900.1 201208 D 559295 CDS KLTH0B02574g 255711236 8290732 complement(202770..203798) 1 NC_013078.1 highly similar to uniprot|P43534 Saccharomyces cerevisiae YFL058W THI5 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13; KLTH0B02574p 203798 8290732 KLTH0B02574g Lachancea thermotolerans CBS 6340 KLTH0B02574p XP_002551901.1 202770 R 559295 CDS KLTH0B02596g 255711238 8290733 204289..204732 1 NC_013078.1 conserved hypothetical protein; KLTH0B02596p 204732 8290733 KLTH0B02596g Lachancea thermotolerans CBS 6340 KLTH0B02596p XP_002551902.1 204289 D 559295 CDS KLTH0B02618g 255711240 8290734 complement(204902..205501) 1 NC_013078.1 similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Ribosomal Like Protein 24; KLTH0B02618p 205501 8290734 KLTH0B02618g Lachancea thermotolerans CBS 6340 KLTH0B02618p XP_002551903.1 204902 R 559295 CDS KLTH0B02640g 255711242 8290735 205524..206159 1 NC_013078.1 similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the mitochondrial import motor associated with the presequence translocase along with Ssc1p Tim44p Mge1p and Pam16p stimulates the ATPase activity of Ssc1p to drive mitochondrial import contains a J domain; KLTH0B02640p 206159 8290735 KLTH0B02640g Lachancea thermotolerans CBS 6340 KLTH0B02640p XP_002551904.1 205524 D 559295 CDS KLTH0B02662g 255711244 8290736 complement(206266..207135) 1 NC_013078.1 weakly similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential nuclear protein required for DNA repair forms a complex with Smc5p and Rhc18p; KLTH0B02662p 207135 8290736 KLTH0B02662g Lachancea thermotolerans CBS 6340 KLTH0B02662p XP_002551905.1 206266 R 559295 CDS KLTH0B02684g 255711246 8290737 207260..209047 1 NC_013078.1 some similarities with uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism dephosphorylated form is degraded by the ubiquitin-proteasome system potential Cdc28p substrate; KLTH0B02684p 209047 8290737 KLTH0B02684g Lachancea thermotolerans CBS 6340 KLTH0B02684p XP_002551906.1 207260 D 559295 CDS KLTH0B02706g 255711248 8290738 209215..211308 1 NC_013078.1 similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 beta-adaptin large subunit of the clathrin- associated protein complex; KLTH0B02706p 211308 8290738 KLTH0B02706g Lachancea thermotolerans CBS 6340 KLTH0B02706p XP_002551907.1 209215 D 559295 CDS KLTH0B02728g 255711250 8290739 complement(211394..212266) 1 NC_013078.1 similar to uniprot|Q07897 YLR003C Saccharomyces cerevisiaeCMS1 Hypothetical ORF; KLTH0B02728p 212266 8290739 KLTH0B02728g Lachancea thermotolerans CBS 6340 KLTH0B02728p XP_002551908.1 211394 R 559295 CDS KLTH0B02750g 255711252 8290740 complement(212432..213997) 1 NC_013078.1 highly similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF; KLTH0B02750p 213997 8290740 KLTH0B02750g Lachancea thermotolerans CBS 6340 KLTH0B02750p XP_002551909.1 212432 R 559295 CDS KLTH0B02772g 255711254 8290741 214541..217132 1 NC_013078.1 conserved hypothetical protein; KLTH0B02772p 217132 8290741 KLTH0B02772g Lachancea thermotolerans CBS 6340 KLTH0B02772p XP_002551910.1 214541 D 559295 CDS KLTH0B02794g 255711256 8290742 217284..218696 1 NC_013078.1 highly similar to uniprot|Q04673 YLR005W Saccharomyces cerevisiae SSL1 Component of RNA polymerase transcription factor TFIIH; KLTH0B02794p 218696 8290742 KLTH0B02794g Lachancea thermotolerans CBS 6340 KLTH0B02794p XP_002551911.1 217284 D 559295 CDS KLTH0B02816g 255711258 8290743 219220..220971 1 NC_013078.1 highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C; KLTH0B02816p 220971 8290743 KLTH0B02816g Lachancea thermotolerans CBS 6340 KLTH0B02816p XP_002551912.1 219220 D 559295 CDS KLTH0B02860g 255711260 8290745 223097..225583 1 NC_013078.1 some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells binds to Aga1p during agglutination N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin C-terminal half is highly glycosylated and contains GPI anchor; KLTH0B02860p 225583 8290745 KLTH0B02860g Lachancea thermotolerans CBS 6340 KLTH0B02860p XP_002551913.1 223097 D 559295 CDS KLTH0B02882g 255711262 8290746 225842..227395 1 NC_013078.1 weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Hypothetical ORF; KLTH0B02882p 227395 8290746 KLTH0B02882g Lachancea thermotolerans CBS 6340 KLTH0B02882p XP_002551914.1 225842 D 559295 CDS KLTH0B02904g 255711264 8290747 complement(227825..228442) 1 NC_013078.1 conserved hypothetical protein; KLTH0B02904p 228442 8290747 KLTH0B02904g Lachancea thermotolerans CBS 6340 KLTH0B02904p XP_002551915.1 227825 R 559295 CDS KLTH0B02926g 255711266 8290748 228615..230591 1 NC_013078.1 similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport also binds to chromatin to promote the association of DNA replication factors and replication initiation; KLTH0B02926p 230591 8290748 KLTH0B02926g Lachancea thermotolerans CBS 6340 KLTH0B02926p XP_002551916.1 228615 D 559295 CDS KLTH0B02948g 255711268 8290749 complement(230675..232498) 1 NC_013078.1 weakly similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W MPP10 Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p; KLTH0B02948p 232498 8290749 KLTH0B02948g Lachancea thermotolerans CBS 6340 KLTH0B02948p XP_002551917.1 230675 R 559295 CDS KLTH0B02970g 255711270 8290750 complement(232632..234431) 1 NC_013078.1 similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters; KLTH0B02970p 234431 8290750 KLTH0B02970g Lachancea thermotolerans CBS 6340 KLTH0B02970p XP_002551918.1 232632 R 559295 CDS KLTH0B02992g 255711272 8290751 complement(234560..235174) 1 NC_013078.1 weakly similar to uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein; KLTH0B02992p 235174 8290751 KLTH0B02992g Lachancea thermotolerans CBS 6340 KLTH0B02992p XP_002551919.1 234560 R 559295 CDS KLTH0B03014g 255711274 8290752 235495..238068 1 NC_013078.1 weakly similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Hypothetical ORF; KLTH0B03014p 238068 8290752 KLTH0B03014g Lachancea thermotolerans CBS 6340 KLTH0B03014p XP_002551920.1 235495 D 559295 CDS KLTH0B03058g 255711276 8290754 complement(238392..240707) 1 NC_013078.1 highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur also participates in endocytosis; KLTH0B03058p 240707 8290754 KLTH0B03058g Lachancea thermotolerans CBS 6340 KLTH0B03058p XP_002551921.1 238392 R 559295 CDS KLTH0B03080g 255711278 8290755 complement(240890..242173) 1 NC_013078.1 similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Regulator of Ty1 Transposition Regulation of mitochondrial network Killed in Mutagen sensitive to diepoxybutane and/or mitomycin C diepoxybutane and mitomycin C resistance; KLTH0B03080p 242173 8290755 KLTH0B03080g Lachancea thermotolerans CBS 6340 KLTH0B03080p XP_002551922.1 240890 R 559295 CDS KLTH0B03102g 255711280 8290756 complement(join(242293..242875,242960..243024)) 1 NC_013078.1 highly similar to uniprot|P38624 YJL001W Saccharomyces cerevisiae PRE3 20S proteasome beta-type subunit; KLTH0B03102p 243024 8290756 KLTH0B03102g Lachancea thermotolerans CBS 6340 KLTH0B03102p XP_002551923.1 242293 R 559295 CDS KLTH0B03124g 255711282 8290757 complement(243194..246085) 1 NC_013078.1 weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1; KLTH0B03124p 246085 8290757 KLTH0B03124g Lachancea thermotolerans CBS 6340 KLTH0B03124p XP_002551924.1 243194 R 559295 CDS KLTH0B03146g 255711284 8290758 246188..247645 1 NC_013078.1 similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins; KLTH0B03146p 247645 8290758 KLTH0B03146g Lachancea thermotolerans CBS 6340 KLTH0B03146p XP_002551925.1 246188 D 559295 CDS KLTH0B03168g 255711286 8290759 complement(247739..249631) 1 NC_013078.1 similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; KLTH0B03168p 249631 8290759 KLTH0B03168g Lachancea thermotolerans CBS 6340 KLTH0B03168p XP_002551926.1 247739 R 559295 CDS KLTH0B03190g 255711288 8290760 complement(250346..250702) 1 NC_013078.1 highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase; KLTH0B03190p 250702 8290760 KLTH0B03190g Lachancea thermotolerans CBS 6340 KLTH0B03190p XP_002551927.1 250346 R 559295 CDS KLTH0B03212g 255711290 8290761 250834..253770 1 NC_013078.1 some similarities with uniprot|Q07798 Saccharomyces cerevisiae YLL005C SPO75 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis; KLTH0B03212p 253770 8290761 KLTH0B03212g Lachancea thermotolerans CBS 6340 KLTH0B03212p XP_002551928.1 250834 D 559295 CDS KLTH0B03234g 255711292 8290762 complement(253796..255139) 1 NC_013078.1 similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids; KLTH0B03234p 255139 8290762 KLTH0B03234g Lachancea thermotolerans CBS 6340 KLTH0B03234p XP_002551929.1 253796 R 559295 CDS KLTH0B03256g 255711294 8290763 255399..257324 1 NC_013078.1 some similarities with uniprot|Q07799 Saccharomyces cerevisiae YLL007C Hypothetical ORF; KLTH0B03256p 257324 8290763 KLTH0B03256g Lachancea thermotolerans CBS 6340 KLTH0B03256p XP_002551930.1 255399 D 559295 CDS KLTH0B03278g 255711296 8290764 complement(257395..259614) 1 NC_013078.1 similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function including synthesis of 60S ribosomal subunits; KLTH0B03278p 259614 8290764 KLTH0B03278g Lachancea thermotolerans CBS 6340 KLTH0B03278p XP_002551931.1 257395 R 559295 CDS KLTH0B03300g 255711298 8290765 259839..260405 1 NC_013078.1 similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Multicopy suppressor of ypt6 null mutation; KLTH0B03300p 260405 8290765 KLTH0B03300g Lachancea thermotolerans CBS 6340 KLTH0B03300p XP_002551932.1 259839 D 559295 CDS KLTH0B03322g 255711300 8290766 complement(262380..268052) 1 NC_013078.1 similar to uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase required for cAMP production and cAMP-dependent protein kinase signaling involved in cell cycle control and glucose and nitrogen repression of sporulation; KLTH0B03322p 268052 8290766 KLTH0B03322g Lachancea thermotolerans CBS 6340 KLTH0B03322p XP_002551933.1 262380 R 559295 CDS KLTH0B03344g 255711302 8290767 270448..271410 1 NC_013078.1 highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP) catalyzes the initial step in the methionine salvage pathway affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity regulates ADH2 gene expression; KLTH0B03344p 271410 8290767 KLTH0B03344g Lachancea thermotolerans CBS 6340 KLTH0B03344p XP_002551934.1 270448 D 559295 CDS KLTH0B03366g 255711304 8290768 complement(271449..272618) 1 NC_013078.1 weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 nuclear pore integral membrane protein; KLTH0B03366p 272618 8290768 KLTH0B03366g Lachancea thermotolerans CBS 6340 KLTH0B03366p XP_002551935.1 271449 R 559295 CDS KLTH0B03388g 255711306 8290769 272914..274143 1 NC_013078.1 similar to uniprot|Q07800 Saccharomyces cerevisiae YLL010C; KLTH0B03388p 274143 8290769 KLTH0B03388g Lachancea thermotolerans CBS 6340 KLTH0B03388p XP_002551936.1 272914 D 559295 CDS KLTH0B03410g 255711308 8290770 complement(276115..277548) 1 NC_013078.1 highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W; KLTH0B03410p 277548 8290770 KLTH0B03410g Lachancea thermotolerans CBS 6340 KLTH0B03410p XP_002551937.1 276115 R 559295 CDS KLTH0B03432g 255711310 8290771 complement(277684..279213) 1 NC_013078.1 similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C YEH2 Steryl ester hydrolase catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism; KLTH0B03432p 279213 8290771 KLTH0B03432g Lachancea thermotolerans CBS 6340 KLTH0B03432p XP_002551938.1 277684 R 559295 CDS KLTH0B03454g 255711312 8290772 279356..279877 1 NC_013078.1 similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W Hypothetical ORF; KLTH0B03454p 279877 8290772 KLTH0B03454g Lachancea thermotolerans CBS 6340 KLTH0B03454p XP_002551939.1 279356 D 559295 CDS KLTH0B03476g 255711314 8290773 complement(279956..280684) 1 NC_013078.1 highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Protein required for cell viability; KLTH0B03476p 280684 8290773 KLTH0B03476g Lachancea thermotolerans CBS 6340 KLTH0B03476p XP_002551940.1 279956 R 559295 CDS KLTH0B03498g 255711316 8290774 complement(281148..282788) 1 NC_013078.1 some similarities with uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc metabolism member of the four-protein IZH family expression induced by zinc deficiency deletion reduces sensitivity to elevated zinc and shortens lag phase overexpression reduces Zap1p activity; KLTH0B03498p 282788 8290774 KLTH0B03498g Lachancea thermotolerans CBS 6340 KLTH0B03498p XP_002551941.1 281148 R 559295 CDS KLTH0B03520g 255711318 8290775 284167..286437 1 NC_013078.1 some similarities with uniprot|Q02601 Saccharomyces cerevisiae YLL013C PUF3 member of the PUF protein family which is named for the founding members PUmilio and Fbf; KLTH0B03520p 286437 8290775 KLTH0B03520g Lachancea thermotolerans CBS 6340 KLTH0B03520p XP_002551942.1 284167 D 559295 CDS KLTH0B03542g 255711320 8290776 complement(286578..286901) 1 NC_013078.1 similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W Hypothetical ORF; KLTH0B03542p 286901 8290776 KLTH0B03542g Lachancea thermotolerans CBS 6340 KLTH0B03542p XP_002551943.1 286578 R 559295 CDS KLTH0B03564g 255711322 8290777 287100..288245 1 NC_013078.1 similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C; KLTH0B03564p 288245 8290777 KLTH0B03564g Lachancea thermotolerans CBS 6340 KLTH0B03564p XP_002551944.1 287100 D 559295 CDS KLTH0B03586g 255711324 8290778 complement(288352..290331) 1 NC_013078.1 similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF) interacts with Fcp1p phosphatase and with TFIIB potentially phosphorylated by Cdc28p; KLTH0B03586p 290331 8290778 KLTH0B03586g Lachancea thermotolerans CBS 6340 KLTH0B03586p XP_002551945.1 288352 R 559295 CDS KLTH0B03608g 255711326 8290779 291073..292290 1 NC_013078.1 highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 tyrosyl-tRNA synthetase cytoplasmic; KLTH0B03608p 292290 8290779 KLTH0B03608g Lachancea thermotolerans CBS 6340 KLTH0B03608p XP_002551946.1 291073 D 559295 CDS KLTH0B03630g 255711328 8290780 complement(292423..297858) 1 NC_013078.1 similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3); KLTH0B03630p 297858 8290780 KLTH0B03630g Lachancea thermotolerans CBS 6340 KLTH0B03630p XP_002551947.1 292423 R 559295 CDS KLTH0B03652g 255711330 8290781 298170..303941 1 NC_013078.1 similar to uniprot|P19812 Saccharomyces cerevisiae YGR184C UBR1 Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway binds to the Rpn2p Rpt1p and Rpt6p proteins of the 19S particle of the 26S proteasome; KLTH0B03652p 303941 8290781 KLTH0B03652g Lachancea thermotolerans CBS 6340 KLTH0B03652p XP_002551948.1 298170 D 559295 CDS KLTH0B03674g 255711332 8290782 join(304162..304164,304585..304797) 1 NC_013078.1 similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex; KLTH0B03674p 304797 8290782 KLTH0B03674g Lachancea thermotolerans CBS 6340 KLTH0B03674p XP_002551949.1 304162 D 559295 CDS KLTH0B03696g 255711334 8290783 complement(305074..305463) 1 NC_013078.1 similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Translocase of the inner membrane mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins Subunit of mitochondrial protein import machinery; KLTH0B03696p 305463 8290783 KLTH0B03696g Lachancea thermotolerans CBS 6340 KLTH0B03696p XP_002551950.1 305074 R 559295 CDS KLTH0B03740g 255711336 8290785 join(306104..306125,306192..306745) 1 NC_013078.1 highly similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin- associated adaptor complex AP-3 which is involved in vacuolar protein sorting related to the sigma subunit of the mammalian clathrin AP-3 complex suppressor of loss of casein kinase 1 function; KLTH0B03740p 306745 8290785 KLTH0B03740g Lachancea thermotolerans CBS 6340 KLTH0B03740p XP_002551951.1 306104 D 559295 CDS KLTH0B03762g 255711338 8290786 complement(306845..307276) 1 NC_013078.1 weakly similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase ubiquinol-- cytochrome-c reductase assembly factor; KLTH0B03762p 307276 8290786 KLTH0B03762g Lachancea thermotolerans CBS 6340 KLTH0B03762p XP_002551952.1 306845 R 559295 CDS KLTH0B03784g 255711340 8290787 complement(307535..309028) 1 NC_013078.1 highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase catalyzes the epoxidation of squalene to 2 3-oxidosqualene plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; KLTH0B03784p 309028 8290787 KLTH0B03784g Lachancea thermotolerans CBS 6340 KLTH0B03784p XP_002551953.1 307535 R 559295 CDS KLTH0B03806g 255711342 8290788 complement(309522..311090) 1 NC_013078.1 similar to uniprot|P40353 Saccharomyces cerevisiae YOR377W ATF1 Alcohol acetyltransferase with potential roles in lipid and sterol metabolism responsible for the major part of volatile acetate ester production during fermentation; KLTH0B03806p 311090 8290788 KLTH0B03806g Lachancea thermotolerans CBS 6340 KLTH0B03806p XP_002551954.1 309522 R 559295 CDS KLTH0B03828g 255711344 8290789 complement(311528..313060) 1 NC_013078.1 similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn6p and TATA- binding protein; KLTH0B03828p 313060 8290789 KLTH0B03828g Lachancea thermotolerans CBS 6340 KLTH0B03828p XP_002551955.1 311528 R 559295 CDS KLTH0B03850g 255711346 8290790 complement(313316..315457) 1 NC_013078.1 similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)- binding protein Pab1p likely involved in control of the extent of mRNA polyadenylation; KLTH0B03850p 315457 8290790 KLTH0B03850g Lachancea thermotolerans CBS 6340 KLTH0B03850p XP_002551956.1 313316 R 559295 CDS KLTH0B03872g 255711348 8290791 complement(315749..316837) 1 NC_013078.1 weakly similar to uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex; KLTH0B03872p 316837 8290791 KLTH0B03872g Lachancea thermotolerans CBS 6340 KLTH0B03872p XP_002551957.1 315749 R 559295 CDS KLTH0B03894g 255711350 8290792 complement(317072..318892) 1 NC_013078.1 weakly similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein; KLTH0B03894p 318892 8290792 KLTH0B03894g Lachancea thermotolerans CBS 6340 KLTH0B03894p XP_002551958.1 317072 R 559295 CDS KLTH0B03916g 255711352 8290793 320151..321128 1 NC_013078.1 highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Protein required for thiamine biosynthesis and for mitochondrial genome stability; KLTH0B03916p 321128 8290793 KLTH0B03916g Lachancea thermotolerans CBS 6340 KLTH0B03916p XP_002551959.1 320151 D 559295 CDS KLTH0B03938g 255711354 8290794 complement(321488..322699) 1 NC_013078.1 highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W RNR2 Ribonucleotide-diphosphate reductase (RNR) small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; KLTH0B03938p 322699 8290794 KLTH0B03938g Lachancea thermotolerans CBS 6340 KLTH0B03938p XP_002551960.1 321488 R 559295 CDS KLTH0B03982g 255711356 8290796 323351..323989 1 NC_013078.1 no similarity; KLTH0B03982p 323989 8290796 KLTH0B03982g Lachancea thermotolerans CBS 6340 KLTH0B03982p XP_002551961.1 323351 D 559295 CDS KLTH0B04004g 255711358 8290797 complement(324153..324614) 1 NC_013078.1 highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis; KLTH0B04004p 324614 8290797 KLTH0B04004g Lachancea thermotolerans CBS 6340 KLTH0B04004p XP_002551962.1 324153 R 559295 CDS KLTH0B04026g 255711360 8290798 325075..325740 1 NC_013078.1 some similarities with uniprot|P11746 Saccharomyces cerevisiae YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes; KLTH0B04026p 325740 8290798 KLTH0B04026g Lachancea thermotolerans CBS 6340 KLTH0B04026p XP_002551963.1 325075 D 559295 CDS KLTH0B04048g 255711362 8290799 326073..327434 1 NC_013078.1 weakly similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing contains a PWWP motif; KLTH0B04048p 327434 8290799 KLTH0B04048g Lachancea thermotolerans CBS 6340 KLTH0B04048p XP_002551964.1 326073 D 559295 CDS KLTH0B04070g 255711364 8290800 complement(327578..331249) 1 NC_013078.1 weakly similar to uniprot|Q02629 Saccharomyces cerevisiae YKL068W NUP100 Subunit of the nuclear pore complex (NPC); KLTH0B04070p 331249 8290800 KLTH0B04070g Lachancea thermotolerans CBS 6340 KLTH0B04070p XP_002551965.1 327578 R 559295 CDS KLTH0B04092g 255711366 8290801 332711..333547 1 NC_013078.1 weakly similar to uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis; KLTH0B04092p 333547 8290801 KLTH0B04092g Lachancea thermotolerans CBS 6340 KLTH0B04092p XP_002551966.1 332711 D 559295 CDS KLTH0B04114g 255711368 8290802 complement(333569..335644) 1 NC_013078.1 conserved hypothetical protein; KLTH0B04114p 335644 8290802 KLTH0B04114g Lachancea thermotolerans CBS 6340 KLTH0B04114p XP_002551967.1 333569 R 559295 CDS KLTH0B04136g 255711370 8290803 complement(335902..338352) 1 NC_013078.1 similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs homologous to mammalian Bop1; KLTH0B04136p 338352 8290803 KLTH0B04136g Lachancea thermotolerans CBS 6340 KLTH0B04136p XP_002551968.1 335902 R 559295 CDS KLTH0B04180g 255711372 8290805 complement(338704..339237) 1 NC_013078.1 similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Hypothetical ORF; KLTH0B04180p 339237 8290805 KLTH0B04180g Lachancea thermotolerans CBS 6340 KLTH0B04180p XP_002551969.1 338704 R 559295 CDS KLTH0B04224g 255711374 8290807 340239..340847 1 NC_013078.1 similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far7p Far8p Far9p Far10p and Far11p; KLTH0B04224p 340847 8290807 KLTH0B04224g Lachancea thermotolerans CBS 6340 KLTH0B04224p XP_002551970.1 340239 D 559295 CDS KLTH0B04246g 255711376 8290808 complement(340919..343189) 1 NC_013078.1 weakly similar to uniprot|P46679 Saccharomyces cerevisiae YMR053C STB2 or to uniprot|P36085 Saccharomyces cerevisiae YKL072W STB6; KLTH0B04246p 343189 8290808 KLTH0B04246g Lachancea thermotolerans CBS 6340 KLTH0B04246p XP_002551971.1 340919 R 559295 CDS KLTH0B04268g 255711378 8290809 join(343801..343825,343937..346512) 1 NC_013078.1 similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Stv1p and Vph1p) Stv1p is located in V- ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; KLTH0B04268p 346512 8290809 KLTH0B04268g Lachancea thermotolerans CBS 6340 KLTH0B04268p XP_002551972.1 343801 D 559295 CDS KLTH0B04290g 255711380 8290810 complement(346686..349340) 1 NC_013078.1 similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen; KLTH0B04290p 349340 8290810 KLTH0B04290g Lachancea thermotolerans CBS 6340 KLTH0B04290p XP_002551973.1 346686 R 559295 CDS KLTH0B04312g 255711382 8290811 349547..350941 1 NC_013078.1 some similarities with uniprot|P36084 Saccharomyces cerevisiae YKL074C; KLTH0B04312p 350941 8290811 KLTH0B04312g Lachancea thermotolerans CBS 6340 KLTH0B04312p XP_002551974.1 349547 D 559295 CDS KLTH0B04334g 255711384 8290812 complement(350971..351879) 1 NC_013078.1 similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator forms GTPase- activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; KLTH0B04334p 351879 8290812 KLTH0B04334g Lachancea thermotolerans CBS 6340 KLTH0B04334p XP_002551975.1 350971 R 559295 CDS KLTH0B04356g 255711386 8290813 353523..355418 1 NC_013078.1 similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high- affinity iron uptake and involved in mediating resistance to copper ion toxicity belongs to class of integral membrane multicopper oxidases; KLTH0B04356p 355418 8290813 KLTH0B04356g Lachancea thermotolerans CBS 6340 KLTH0B04356p XP_002551976.1 353523 D 559295 CDS KLTH0B04378g 255711388 8290814 356395..357537 1 NC_013078.1 similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Hypothetical ORF; KLTH0B04378p 357537 8290814 KLTH0B04378g Lachancea thermotolerans CBS 6340 KLTH0B04378p XP_002551977.1 356395 D 559295 CDS KLTH0B04400g 255711390 8290815 complement(357622..358890) 1 NC_013078.1 similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W; KLTH0B04400p 358890 8290815 KLTH0B04400g Lachancea thermotolerans CBS 6340 KLTH0B04400p XP_002551978.1 357622 R 559295 CDS KLTH0B04422g 255711392 8290816 358915..359253 1 NC_013078.1 similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p; KLTH0B04422p 359253 8290816 KLTH0B04422g Lachancea thermotolerans CBS 6340 KLTH0B04422p XP_002551979.1 358915 D 559295 CDS KLTH0B04444g 255711394 8290817 complement(359264..360151) 1 NC_013078.1 similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex required for the sorting of some proteins to the outer membrane after import by the TOM complex; KLTH0B04444p 360151 8290817 KLTH0B04444g Lachancea thermotolerans CBS 6340 KLTH0B04444p XP_002551980.1 359264 R 559295 CDS KLTH0B04466g 255711396 8290818 360380..362344 1 NC_013078.1 similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends bridges interaction between Rna15p and Hrp1p in the CF I complex; KLTH0B04466p 362344 8290818 KLTH0B04466g Lachancea thermotolerans CBS 6340 KLTH0B04466p XP_002551981.1 360380 D 559295 CDS KLTH0B04488g 255711398 8290819 complement(362390..363715) 1 NC_013078.1 highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ECM40 Mitochondrial ornithine acetyltransferase catalyzes the fifth step in arginine biosynthesis also possesses acetylglutamate synthase activity regenerates acetylglutamate while forming ornithine; KLTH0B04488p 363715 8290819 KLTH0B04488g Lachancea thermotolerans CBS 6340 KLTH0B04488p XP_002551982.1 362390 R 559295 CDS KLTH0B04510g 255711400 8290820 complement(364062..365768) 1 NC_013078.1 highly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock; KLTH0B04510p 365768 8290820 KLTH0B04510g Lachancea thermotolerans CBS 6340 KLTH0B04510p XP_002551983.1 364062 R 559295 CDS KLTH0B04532g 255711402 8290821 367438..367770 1 NC_013078.1 conserved hypothetical protein; KLTH0B04532p 367770 8290821 KLTH0B04532g Lachancea thermotolerans CBS 6340 KLTH0B04532p XP_002551984.1 367438 D 559295 CDS KLTH0B04554g 255711404 8290822 367962..370022 1 NC_013078.1 weakly similar to uniprot|P53309 Saccharomyces cerevisiae YGR241C; KLTH0B04554p 370022 8290822 KLTH0B04554g Lachancea thermotolerans CBS 6340 KLTH0B04554p XP_002551985.1 367962 D 559295 CDS KLTH0B04576g 255711406 8290823 370504..373431 1 NC_013078.1 highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6- bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes; KLTH0B04576p 373431 8290823 KLTH0B04576g Lachancea thermotolerans CBS 6340 KLTH0B04576p XP_002551986.1 370504 D 559295 CDS KLTH0B04598g 255711408 8290824 complement(373616..375145) 1 NC_013078.1 weakly similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen may form a complex with Jem1p and Kar2p expression of the gene is regulated by pheromone; KLTH0B04598p 375145 8290824 KLTH0B04598g Lachancea thermotolerans CBS 6340 KLTH0B04598p XP_002551987.1 373616 R 559295 CDS KLTH0B04620g 255711410 8290825 complement(375653..377353) 1 NC_013078.1 weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase; KLTH0B04620p 377353 8290825 KLTH0B04620g Lachancea thermotolerans CBS 6340 KLTH0B04620p XP_002551988.1 375653 R 559295 CDS KLTH0B04642g 255711412 8290826 complement(377498..378223) 1 NC_013078.1 weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W; KLTH0B04642p 378223 8290826 KLTH0B04642g Lachancea thermotolerans CBS 6340 KLTH0B04642p XP_002551989.1 377498 R 559295 CDS KLTH0B04664g 255711414 8290827 378488..380590 1 NC_013078.1 similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box RNA helicase required for 18S rRNA synthesis; KLTH0B04664p 380590 8290827 KLTH0B04664g Lachancea thermotolerans CBS 6340 KLTH0B04664p XP_002551990.1 378488 D 559295 CDS KLTH0B04686g 255711416 8290828 381618..381932 1 NC_013078.1 conserved hypothetical protein; KLTH0B04686p 381932 8290828 KLTH0B04686g Lachancea thermotolerans CBS 6340 KLTH0B04686p XP_002551991.1 381618 D 559295 CDS KLTH0B04708g 255711418 8290829 383780..390259 1 NC_013078.1 highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD( )-dependent glutamate synthase (GOGAT) synthesizes glutamate from glutamine and alpha-ketoglutarate with Gln1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source; KLTH0B04708p 390259 8290829 KLTH0B04708g Lachancea thermotolerans CBS 6340 KLTH0B04708p XP_002551992.1 383780 D 559295 CDS KLTH0B04730g 255711420 8290830 complement(390460..390954) 1 NC_013078.1 some similarities with uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W Hypothetical ORF; KLTH0B04730p 390954 8290830 KLTH0B04730g Lachancea thermotolerans CBS 6340 KLTH0B04730p XP_002551993.1 390460 R 559295 CDS KLTH0B04752g 255711422 8290831 391353..392171 1 NC_013078.1 similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA; KLTH0B04752p 392171 8290831 KLTH0B04752g Lachancea thermotolerans CBS 6340 KLTH0B04752p XP_002551994.1 391353 D 559295 CDS KLTH0B04774g 255711424 8290832 392485..394206 1 NC_013078.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane; KLTH0B04774p 394206 8290832 KLTH0B04774g Lachancea thermotolerans CBS 6340 KLTH0B04774p XP_002551995.1 392485 D 559295 CDS KLTH0B04796g 255711426 8290833 394777..395400 1 NC_013078.1 conserved hypothetical protein; KLTH0B04796p 395400 8290833 KLTH0B04796g Lachancea thermotolerans CBS 6340 KLTH0B04796p XP_002551996.1 394777 D 559295 CDS KLTH0B04818g 255711428 8290834 complement(395490..396632) 1 NC_013078.1 weakly similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane receptor; KLTH0B04818p 396632 8290834 KLTH0B04818g Lachancea thermotolerans CBS 6340 KLTH0B04818p XP_002551997.1 395490 R 559295 CDS KLTH0B04862g 255711430 8290836 complement(397225..398769) 1 NC_013078.1 some similarities with uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane localizes only to mitochondria of the bud interacts with Myo2p to mediate mitochondrial distribution to buds mRNA is targeted to the bud via the transport system involving She2p; KLTH0B04862p 398769 8290836 KLTH0B04862g Lachancea thermotolerans CBS 6340 KLTH0B04862p XP_002551998.1 397225 R 559295 CDS KLTH0B04884g 255711432 8290837 400193..401914 1 NC_013078.1 highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; KLTH0B04884p 401914 8290837 KLTH0B04884g Lachancea thermotolerans CBS 6340 KLTH0B04884p XP_002551999.1 400193 D 559295 CDS KLTH0B04906g 255711434 8290838 402179..403885 1 NC_013078.1 similar to uniprot|P39965 Saccharomyces cerevisiae YER087W Hypothetical ORF; KLTH0B04906p 403885 8290838 KLTH0B04906g Lachancea thermotolerans CBS 6340 KLTH0B04906p XP_002552000.1 402179 D 559295 CDS KLTH0B04928g 255711436 8290839 complement(403949..404218) 1 NC_013078.1 highly similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A SBH2 Ssh1p-Sss1p-Sbh2p complex component involved in protein translocation into the endoplasmic reticulum homologous to Sbh1p; KLTH0B04928p 404218 8290839 KLTH0B04928g Lachancea thermotolerans CBS 6340 KLTH0B04928p XP_002552001.1 403949 R 559295 CDS KLTH0B04950g 255711438 8290840 405537..407279 1 NC_013078.1 some similarities with uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage interacts with Rad53p contains an RNA recognition motif a nuclear localization signal and several SQ/TQ cluster domains hyperphosphorylated in response to DNA damage; KLTH0B04950p 407279 8290840 KLTH0B04950g Lachancea thermotolerans CBS 6340 KLTH0B04950p XP_002552002.1 405537 D 559295 CDS KLTH0B04972g 255711440 8290841 408153..409235 1 NC_013078.1 highly similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance; KLTH0B04972p 409235 8290841 KLTH0B04972g Lachancea thermotolerans CBS 6340 KLTH0B04972p XP_002552003.1 408153 D 559295 CDS KLTH0B04994g 255711442 8290842 409558..411780 1 NC_013078.1 some similarities with uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3 involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene sas3 gcn5 double mutation confers lethality; KLTH0B04994p 411780 8290842 KLTH0B04994g Lachancea thermotolerans CBS 6340 KLTH0B04994p XP_002552004.1 409558 D 559295 CDS KLTH0B05016g 255711444 8290843 complement(412037..413824) 1 NC_013078.1 some similarities with uniprot|P40059 Saccharomyces cerevisiae YER088C DOT6 Protein of unknown function involved in telomeric gene silencing and filamentation; KLTH0B05016p 413824 8290843 KLTH0B05016g Lachancea thermotolerans CBS 6340 KLTH0B05016p XP_002552005.1 412037 R 559295 CDS KLTH0B05038g 255711446 8290844 join(415138..415176,415852..416868) 1 NC_013078.1 conserved hypothetical protein; KLTH0B05038p 416868 8290844 KLTH0B05038g Lachancea thermotolerans CBS 6340 KLTH0B05038p XP_002552006.1 415138 D 559295 CDS KLTH0B05060g 255711448 8290845 complement(416976..418274) 1 NC_013078.1 conserved hypothetical protein; KLTH0B05060p 418274 8290845 KLTH0B05060g Lachancea thermotolerans CBS 6340 KLTH0B05060p XP_002552007.1 416976 R 559295 CDS KLTH0B05082g 255711450 8290846 complement(419442..420332) 1 NC_013078.1 conserved hypothetical protein; KLTH0B05082p 420332 8290846 KLTH0B05082g Lachancea thermotolerans CBS 6340 KLTH0B05082p XP_002552008.1 419442 R 559295 CDS KLTH0B05104g 255711452 8290847 420999..423680 1 NC_013078.1 similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Protein required for the decapping of mRNAs functions to allow the production of active Dcp1p contains a pyrophosphatase MutT motif and several alpha- helical leucine-rich motifs; KLTH0B05104p 423680 8290847 KLTH0B05104g Lachancea thermotolerans CBS 6340 KLTH0B05104p XP_002552009.1 420999 D 559295 CDS KLTH0B05126g 255711454 8290848 complement(423735..425168) 1 NC_013078.1 similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth inhibits replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive- strand RNA viruses in their natural hosts; KLTH0B05126p 425168 8290848 KLTH0B05126g Lachancea thermotolerans CBS 6340 KLTH0B05126p XP_002552010.1 423735 R 559295 CDS KLTH0B05148g 255711456 8290849 426037..426372 1 NC_013078.1 similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis essential for functional cytochrome oxidase expression homologous to Cox17p; KLTH0B05148p 426372 8290849 KLTH0B05148g Lachancea thermotolerans CBS 6340 KLTH0B05148p XP_002552011.1 426037 D 559295 CDS KLTH0B05170g 255711458 8290850 427608..429389 1 NC_013078.1 similar to uniprot|P07213 Saccharomyces cerevisiae YNL121C TOM70 Translocase of Outer Mitochondrial membrane 70 kDa mitochondrial specialized import receptor of the outer membrane; KLTH0B05170p 429389 8290850 KLTH0B05170g Lachancea thermotolerans CBS 6340 KLTH0B05170p XP_002552012.1 427608 D 559295 CDS KLTH0B05192g 255711460 8290851 complement(429511..429930) 1 NC_013078.1 conserved hypothetical protein; KLTH0B05192p 429930 8290851 KLTH0B05192g Lachancea thermotolerans CBS 6340 KLTH0B05192p XP_002552013.1 429511 R 559295 CDS KLTH0B05214g 255711462 8290852 430231..430506 1 NC_013078.1 some similarities with uniprot|P53921 Saccharomyces cerevisiae YNL122C Hypothetical ORF; KLTH0B05214p 430506 8290852 KLTH0B05214g Lachancea thermotolerans CBS 6340 KLTH0B05214p XP_002552014.1 430231 D 559295 CDS KLTH0B05236g 255711464 8290853 complement(430626..433568) 1 NC_013078.1 highly similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W shows protein sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; KLTH0B05236p 433568 8290853 KLTH0B05236g Lachancea thermotolerans CBS 6340 KLTH0B05236p XP_002552015.1 430626 R 559295 CDS KLTH0B05258g 255711466 8290854 complement(433847..435127) 1 NC_013078.1 similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p; KLTH0B05258p 435127 8290854 KLTH0B05258g Lachancea thermotolerans CBS 6340 KLTH0B05258p XP_002552016.1 433847 R 559295 CDS KLTH0B05280g 255711468 8290855 435558..438518 1 NC_013078.1 similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres contains a SET domain; KLTH0B05280p 438518 8290855 KLTH0B05280g Lachancea thermotolerans CBS 6340 KLTH0B05280p XP_002552017.1 435558 D 559295 CDS KLTH0B05302g 255711470 8290856 438719..441667 1 NC_013078.1 similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis; KLTH0B05302p 441667 8290856 KLTH0B05302g Lachancea thermotolerans CBS 6340 KLTH0B05302p XP_002552018.1 438719 D 559295 CDS KLTH0B05324g 255711472 8290857 complement(441709..443148) 1 NC_013078.1 some similarities with uniprot|P53919 Saccharomyces cerevisiae YNL124W; KLTH0B05324p 443148 8290857 KLTH0B05324g Lachancea thermotolerans CBS 6340 KLTH0B05324p XP_002552019.1 441709 R 559295 CDS KLTH0B05346g 255711474 8290858 complement(443928..446447) 1 NC_013078.1 similar to uniprot|P53540 Saccharomyces cerevisiae YNL126W SPC98 Component of the microtubule- nucleating Tub4p (gamma-tubulin) complex interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque; KLTH0B05346p 446447 8290858 KLTH0B05346g Lachancea thermotolerans CBS 6340 KLTH0B05346p XP_002552020.1 443928 R 559295 CDS KLTH0B05368g 255711476 8290859 complement(446569..449364) 1 NC_013078.1 similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far8p Far9p and Far10p; KLTH0B05368p 449364 8290859 KLTH0B05368g Lachancea thermotolerans CBS 6340 KLTH0B05368p XP_002552021.1 446569 R 559295 CDS KLTH0B05390g 255711478 8290860 449461..449811 1 NC_013078.1 some similarities with uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein containing an Lsm domain and an AD domain may bind RNA and have a role in RNA processing; KLTH0B05390p 449811 8290860 KLTH0B05390g Lachancea thermotolerans CBS 6340 KLTH0B05390p XP_002552022.1 449461 D 559295 CDS KLTH0B05412g 255711480 8290861 complement(449900..451240) 1 NC_013078.1 similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W; KLTH0B05412p 451240 8290861 KLTH0B05412g Lachancea thermotolerans CBS 6340 KLTH0B05412p XP_002552023.1 449900 R 559295 CDS KLTH0B05434g 255711482 8290862 complement(join(451373..452032,452105..452164)) 1 NC_013078.1 similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside involved in a salvage pathway for NAD biosynthesis; KLTH0B05434p 452164 8290862 KLTH0B05434g Lachancea thermotolerans CBS 6340 KLTH0B05434p XP_002552024.1 451373 R 559295 CDS KLTH0B05456g 255711484 8290863 454571..455239 1 NC_013078.1 similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein required for cell viability; KLTH0B05456p 455239 8290863 KLTH0B05456g Lachancea thermotolerans CBS 6340 KLTH0B05456p XP_002552025.1 454571 D 559295 CDS KLTH0B05478g 255711486 8290864 455601..456638 1 NC_013078.1 similar to uniprot|P17898 Saccharomyces cerevisiae YNL130C CPT1 and similar to uniprot|P22140 Saccharomyces cerevisiae YHR123w EPT1; KLTH0B05478p 456638 8290864 KLTH0B05478g Lachancea thermotolerans CBS 6340 KLTH0B05478p XP_002552026.1 455601 D 559295 CDS KLTH0B05500g 255711488 8290865 complement(456831..457268) 1 NC_013078.1 similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Translocase of Outer Mitochondrial membrane Mitochondrial import receptor complex protein; KLTH0B05500p 457268 8290865 KLTH0B05500g Lachancea thermotolerans CBS 6340 KLTH0B05500p XP_002552027.1 456831 R 559295 CDS KLTH0B05522g 255711490 8290866 complement(457520..460687) 1 NC_013078.1 highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; KLTH0B05522p 460687 8290866 KLTH0B05522g Lachancea thermotolerans CBS 6340 KLTH0B05522p XP_002552028.1 457520 R 559295 CDS KLTH0B05544g 255711492 8290867 461312..463489 1 NC_013078.1 similar to uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination activates middle sporulation genes competes with Sum1p for binding to promoters containing middle sporulation elements (MSE); KLTH0B05544p 463489 8290867 KLTH0B05544g Lachancea thermotolerans CBS 6340 KLTH0B05544p XP_002552029.1 461312 D 559295 CDS KLTH0B05588g 255711494 8290869 463936..464478 1 NC_013078.1 weakly similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function required for survival upon exposure to K1 killer toxin proposed to regulate double-strand break repair via non- homologous end-joining; KLTH0B05588p 464478 8290869 KLTH0B05588g Lachancea thermotolerans CBS 6340 KLTH0B05588p XP_002552030.1 463936 D 559295 CDS KLTH0B05610g 255711496 8290870 464789..465904 1 NC_013078.1 similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C; KLTH0B05610p 465904 8290870 KLTH0B05610g Lachancea thermotolerans CBS 6340 KLTH0B05610p XP_002552031.1 464789 D 559295 CDS KLTH0B05632g 255711498 8290871 complement(466200..466475) 1 NC_013078.1 similar to uniprot|P43497 Saccharomyces cerevisiae YKL096W-A CWP2 major constituent of the cell wall containing GPI-anchor, plays a role in stabilizing the cell wall, low pH resistance protein; KLTH0B05632p 466475 8290871 KLTH0B05632g Lachancea thermotolerans CBS 6340 KLTH0B05632p XP_002552032.1 466200 R 559295 CDS KLTH0B05654g 255711500 8290872 467957..468301 1 NC_013078.1 highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; KLTH0B05654p 468301 8290872 KLTH0B05654g Lachancea thermotolerans CBS 6340 KLTH0B05654p XP_002552033.1 467957 D 559295 CDS KLTH0B05676g 255711502 8290873 complement(468367..469491) 1 NC_013078.1 some similarities with uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex which acetylates the N-terminal tails of histones H4 and H2A; KLTH0B05676p 469491 8290873 KLTH0B05676g Lachancea thermotolerans CBS 6340 KLTH0B05676p XP_002552034.1 468367 R 559295 CDS KLTH0B05698g 255711504 8290874 469761..471203 1 NC_013078.1 similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit; KLTH0B05698p 471203 8290874 KLTH0B05698g Lachancea thermotolerans CBS 6340 KLTH0B05698p XP_002552035.1 469761 D 559295 CDS KLTH0B05720g 255711506 8290875 complement(471311..472903) 1 NC_013078.1 similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 Adenylyl cyclase-associated protein N- terminal domain appears to be involved in cellular responsiveness to RAS; KLTH0B05720p 472903 8290875 KLTH0B05720g Lachancea thermotolerans CBS 6340 KLTH0B05720p XP_002552036.1 471311 R 559295 CDS KLTH0B05742g 255711508 8290876 473057..473707 1 NC_013078.1 weakly similar to uniprot|P38833 Saccharomyces cerevisiae YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4; KLTH0B05742p 473707 8290876 KLTH0B05742g Lachancea thermotolerans CBS 6340 KLTH0B05742p XP_002552037.1 473057 D 559295 CDS KLTH0B05764g 255711510 8290877 complement(join(473754..474041,474107..474109)) 1 NC_013078.1 similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A RCP10; KLTH0B05764p 474109 8290877 KLTH0B05764g Lachancea thermotolerans CBS 6340 KLTH0B05764p XP_002552038.1 473754 R 559295 CDS KLTH0B05786g 255711512 8290878 474183..479222 1 NC_013078.1 similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C RLR1 Required for LacZ RNA expression from certain plasmids suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) plays a role in transcription elongation by RNA polymerase II Involved in transcription; KLTH0B05786p 479222 8290878 KLTH0B05786g Lachancea thermotolerans CBS 6340 KLTH0B05786p XP_002552039.1 474183 D 559295 CDS KLTH0B05808g 255711514 8290879 479404..480567 1 NC_013078.1 weakly similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W Protein required for cell viability; KLTH0B05808p 480567 8290879 KLTH0B05808g Lachancea thermotolerans CBS 6340 KLTH0B05808p XP_002552040.1 479404 D 559295 CDS KLTH0B05830g 255711516 8290880 complement(480876..481574) 1 NC_013078.1 similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31 contains HMG- like C-terminal domain; KLTH0B05830p 481574 8290880 KLTH0B05830g Lachancea thermotolerans CBS 6340 KLTH0B05830p XP_002552041.1 480876 R 559295 CDS KLTH0B05852g 255711518 8290881 complement(481757..482137) 1 NC_013078.1 weakly similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C Protein required for cell viability; KLTH0B05852p 482137 8290881 KLTH0B05852g Lachancea thermotolerans CBS 6340 KLTH0B05852p XP_002552042.1 481757 R 559295 CDS KLTH0B05874g 255711520 8290882 complement(482270..483013) 1 NC_013078.1 similar to uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 alpha-tubulin foldin protein implicated in folding of alpha tubulin cofactor B; KLTH0B05874p 483013 8290882 KLTH0B05874g Lachancea thermotolerans CBS 6340 KLTH0B05874p XP_002552043.1 482270 R 559295 CDS KLTH0B05896g 255711522 8290883 join(483135..483146,483264..483587) 1 NC_013078.1 highly similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; KLTH0B05896p 483587 8290883 KLTH0B05896g Lachancea thermotolerans CBS 6340 KLTH0B05896p XP_002552044.1 483135 D 559295 CDS KLTH0B05918g 255711524 8290884 484444..485094 1 NC_013078.1 highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase synthesizes UMP from uracil involved in the pyrimidine salvage pathway; KLTH0B05918p 485094 8290884 KLTH0B05918g Lachancea thermotolerans CBS 6340 KLTH0B05918p XP_002552045.1 484444 D 559295 CDS KLTH0B05940g 255711526 8290885 complement(485135..486286) 1 NC_013078.1 similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex required for spindle orientation and nuclear migration putative ortholog of mammalian centractin; KLTH0B05940p 486286 8290885 KLTH0B05940g Lachancea thermotolerans CBS 6340 KLTH0B05940p XP_002552046.1 485135 R 559295 CDS KLTH0B05962g 255711528 8290886 complement(486413..488239) 1 NC_013078.1 conserved hypothetical protein; KLTH0B05962p 488239 8290886 KLTH0B05962g Lachancea thermotolerans CBS 6340 KLTH0B05962p XP_002552047.1 486413 R 559295 CDS KLTH0B05984g 255711530 8290887 complement(489699..491867) 1 NC_013078.1 similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C Hypothetical ORF; KLTH0B05984p 491867 8290887 KLTH0B05984g Lachancea thermotolerans CBS 6340 KLTH0B05984p XP_002552048.1 489699 R 559295 CDS KLTH0B06006g 255711532 8290888 complement(492629..493867) 1 NC_013078.1 conserved hypothetical protein; KLTH0B06006p 493867 8290888 KLTH0B06006g Lachancea thermotolerans CBS 6340 KLTH0B06006p XP_002552049.1 492629 R 559295 CDS KLTH0B06028g 255711534 8290889 complement(494230..495027) 1 NC_013078.1 some similarities with uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Predicted membrane protein genetic interactions suggest a role in negative regulation of amino acid uptake; KLTH0B06028p 495027 8290889 KLTH0B06028g Lachancea thermotolerans CBS 6340 KLTH0B06028p XP_002552050.1 494230 R 559295 CDS KLTH0B06050g 255711536 8290890 495028..495585 1 NC_013078.1 weakly similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; KLTH0B06050p 495585 8290890 KLTH0B06050g Lachancea thermotolerans CBS 6340 KLTH0B06050p XP_002552051.1 495028 D 559295 CDS KLTH0B06072g 255711538 8290891 complement(495614..496924) 1 NC_013078.1 similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C; KLTH0B06072p 496924 8290891 KLTH0B06072g Lachancea thermotolerans CBS 6340 KLTH0B06072p XP_002552052.1 495614 R 559295 CDS KLTH0B06094g 255711540 8290892 497336..497725 1 NC_013078.1 highly similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A Hypothetical ORF; KLTH0B06094p 497725 8290892 KLTH0B06094g Lachancea thermotolerans CBS 6340 KLTH0B06094p XP_002552053.1 497336 D 559295 CDS KLTH0B06116g 255711542 8290893 complement(497825..498613) 1 NC_013078.1 similar to uniprot|P53898 Saccharomyces cerevisiae YNL156C NSG2 Protein of unknown function potential homolog of mammalian Insig 1; KLTH0B06116p 498613 8290893 KLTH0B06116g Lachancea thermotolerans CBS 6340 KLTH0B06116p XP_002552054.1 497825 R 559295 CDS KLTH0B06138g 255711544 8290894 498882..499577 1 NC_013078.1 similar to uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 weak suppressor of smt3; KLTH0B06138p 499577 8290894 KLTH0B06138g Lachancea thermotolerans CBS 6340 KLTH0B06138p XP_002552055.1 498882 D 559295 CDS KLTH0B06160g 255711546 8290895 499948..500733 1 NC_013078.1 similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Hypothetical ORF; KLTH0B06160p 500733 8290895 KLTH0B06160g Lachancea thermotolerans CBS 6340 KLTH0B06160p XP_002552056.1 499948 D 559295 CDS KLTH0B06182g 255711548 8290896 500939..502024 1 NC_013078.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2; KLTH0B06182p 502024 8290896 KLTH0B06182g Lachancea thermotolerans CBS 6340 KLTH0B06182p XP_002552057.1 500939 D 559295 CDS KLTH0B06204g 255711550 8290897 complement(502282..503778) 1 NC_013078.1 some similarities with uniprot|P23292 Saccharomyces cerevisiae YNL154C YCK2 membrane-bound casein kinase I homolog; KLTH0B06204p 503778 8290897 KLTH0B06204g Lachancea thermotolerans CBS 6340 KLTH0B06204p XP_002552058.1 502282 R 559295 CDS KLTH0B06226g 255711552 8290898 505357..506424 1 NC_013078.1 similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase) involved in purine salvage and nitrogen catabolism; KLTH0B06226p 506424 8290898 KLTH0B06226g Lachancea thermotolerans CBS 6340 KLTH0B06226p XP_002552059.1 505357 D 559295 CDS KLTH0B06248g 255711554 8290899 complement(506590..507123) 1 NC_013078.1 conserved hypothetical protein; KLTH0B06248p 507123 8290899 KLTH0B06248g Lachancea thermotolerans CBS 6340 KLTH0B06248p XP_002552060.1 506590 R 559295 CDS KLTH0B06270g 255711556 8290900 508642..510219 1 NC_013078.1 similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase catalyzes the first step of tryptophan phenylalanine and tyrosine catabolism; KLTH0B06270p 510219 8290900 KLTH0B06270g Lachancea thermotolerans CBS 6340 KLTH0B06270p XP_002552061.1 508642 D 559295 CDS KLTH0B06292g 255711558 8290901 join(510493..510501,510567..510947) 1 NC_013078.1 similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin; KLTH0B06292p 510947 8290901 KLTH0B06292g Lachancea thermotolerans CBS 6340 KLTH0B06292p XP_002552062.1 510493 D 559295 CDS KLTH0B06314g 255711560 8290902 complement(join(511087..511370,511440..511500)) 1 NC_013078.1 similar to uniprot|P38841 Saccharomyces cerevisiae YHR138C Homologous to PBI2; KLTH0B06314p 511500 8290902 KLTH0B06314g Lachancea thermotolerans CBS 6340 KLTH0B06314p XP_002552063.1 511087 R 559295 CDS KLTH0B06336g 255711562 8290903 complement(511768..513249) 1 NC_013078.1 similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4 ) expression is under the nitrogen catabolite repression regulation; KLTH0B06336p 513249 8290903 KLTH0B06336g Lachancea thermotolerans CBS 6340 KLTH0B06336p XP_002552064.1 511768 R 559295 CDS KLTH0B06358g 255711564 8290904 complement(513940..514731) 1 NC_013078.1 weakly similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Hypothetical ORF; KLTH0B06358p 514731 8290904 KLTH0B06358g Lachancea thermotolerans CBS 6340 KLTH0B06358p XP_002552065.1 513940 R 559295 CDS KLTH0B06380g 255711566 8290905 515228..516265 1 NC_013078.1 similar to uniprot|P38616 Saccharomyces cerevisiae YNL160W YGP1 may be involved in cellular adaptations prior to stationary phase YGP1 encodes gp37 a glycoprotein synthesized in response to nutrient limitation which is homologous to the sporulation-specific SPS100 gene; KLTH0B06380p 516265 8290905 KLTH0B06380g Lachancea thermotolerans CBS 6340 KLTH0B06380p XP_002552066.1 515228 D 559295 CDS KLTH0B06402g 255711568 8290906 complement(516622..517707) 1 NC_013078.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 NADPH-dependent methylglyoxal reductase; KLTH0B06402p 517707 8290906 KLTH0B06402g Lachancea thermotolerans CBS 6340 KLTH0B06402p XP_002552067.1 516622 R 559295 CDS KLTH0B06424g 255711570 8290907 complement(518184..520328) 1 NC_013078.1 similar to uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Protein kinase involved in cell wall biosynthesis required for efficient apical growth proper mating projection morphology bipolar bud site selection in diploid cells and cell separation; KLTH0B06424p 520328 8290907 KLTH0B06424g Lachancea thermotolerans CBS 6340 KLTH0B06424p XP_002552068.1 518184 R 559295 CDS KLTH0B06446g 255711572 8290908 complement(join(520647..520963,521299..521302)) 1 NC_013078.1 highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C RPL42B and highly similar to uniprot|P02405 Saccharomyces cerevisiae YNL162W RPL42A Proteins component of the large (60S) ribosomal subunit; KLTH0B06446p 521302 8290908 KLTH0B06446g Lachancea thermotolerans CBS 6340 KLTH0B06446p XP_002552069.1 520647 R 559295 CDS KLTH0B06468g 255711574 8290909 522154..523107 1 NC_013078.1 similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7; KLTH0B06468p 523107 8290909 KLTH0B06468g Lachancea thermotolerans CBS 6340 KLTH0B06468p XP_002552070.1 522154 D 559295 CDS KLTH0B06490g 255711576 8290910 complement(523220..523429) 1 NC_013078.1 similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A Hypothetical ORF; KLTH0B06490p 523429 8290910 KLTH0B06490g Lachancea thermotolerans CBS 6340 KLTH0B06490p XP_002552071.1 523220 R 559295 CDS KLTH0B06512g 255711578 8290911 523580..526882 1 NC_013078.1 similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C; KLTH0B06512p 526882 8290911 KLTH0B06512g Lachancea thermotolerans CBS 6340 KLTH0B06512p XP_002552072.1 523580 D 559295 CDS KLTH0B06534g 255711580 8290912 527044..527943 1 NC_013078.1 weakly similar to uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway interacts with Bfa1p and functions upstream of Bub2p and Bfa1p; KLTH0B06534p 527943 8290912 KLTH0B06534g Lachancea thermotolerans CBS 6340 KLTH0B06534p XP_002552073.1 527044 D 559295 CDS KLTH0B06556g 255711582 8290913 528699..529601 1 NC_013078.1 some similarities with uniprot|P38844 Saccharomyces cerevisiae YHR143W DSE2 daughter-specific expression protein 2; KLTH0B06556p 529601 8290913 KLTH0B06556g Lachancea thermotolerans CBS 6340 KLTH0B06556p XP_002552074.1 528699 D 559295 CDS KLTH0B06578g 255711584 8290914 complement(529673..530818) 1 NC_013078.1 similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF; KLTH0B06578p 530818 8290914 KLTH0B06578g Lachancea thermotolerans CBS 6340 KLTH0B06578p XP_002552075.1 529673 R 559295 CDS KLTH0B06600g 255711586 8290915 531018..532247 1 NC_013078.1 weakly similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck may interact directly with the Cdc11p septin localizes to bud neck in a septin- dependent manner; KLTH0B06600p 532247 8290915 KLTH0B06600g Lachancea thermotolerans CBS 6340 KLTH0B06600p XP_002552076.1 531018 D 559295 CDS KLTH0B06622g 255711588 8290916 532482..532694 1 NC_013078.1 highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10- alpha common to RNA polymerases I II and III; KLTH0B06622p 532694 8290916 KLTH0B06622g Lachancea thermotolerans CBS 6340 KLTH0B06622p XP_002552077.1 532482 D 559295 CDS KLTH0B06688g 255711590 8290917 537899..538249 1 NC_013078.1 conserved hypothetical protein; KLTH0B06688p 538249 8290917 KLTH0B06688g Lachancea thermotolerans CBS 6340 KLTH0B06688p XP_002552078.1 537899 D 559295 CDS KLTH0B06710g 255711592 8290918 538970..540142 1 NC_013078.1 weakly similar to uniprot|P38723 Saccharomyces cerevisiae YHL048W COS8 Nuclear membrane protein member of a family of conserved often subtelomerically-encoded proteins regulation suggests a potential role in the unfolded protein response; KLTH0B06710p 540142 8290918 KLTH0B06710g Lachancea thermotolerans CBS 6340 KLTH0B06710p XP_002552079.1 538970 D 559295 CDS KLTH0B06732g 255711594 8290919 541428..543518 1 NC_013078.1 some similarities with uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that forms a complex with Tup1p and Ssn6p to both activate and repress transcription cytosolic and nuclear protein involved in the osmotic and oxidative stress responses; KLTH0B06732p 543518 8290919 KLTH0B06732g Lachancea thermotolerans CBS 6340 KLTH0B06732p XP_002552080.1 541428 D 559295 CDS KLTH0B06754g 255711596 8290920 543748..544752 1 NC_013078.1 similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 The authentic non-tagged protein was localized to mitochondria; KLTH0B06754p 544752 8290920 KLTH0B06754g Lachancea thermotolerans CBS 6340 KLTH0B06754p XP_002552081.1 543748 D 559295 CDS KLTH0B06776g 255711598 8290921 complement(544782..545789) 1 NC_013078.1 similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deaminase required for dCTP and dTTP synthesis expression is cell cycle regulated; KLTH0B06776p 545789 8290921 KLTH0B06776g Lachancea thermotolerans CBS 6340 KLTH0B06776p XP_002552082.1 544782 R 559295 CDS KLTH0B06798g 255711600 8290922 546016..547554 1 NC_013078.1 similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane converts phosphatidylserine to phosphatidylethanolamine; KLTH0B06798p 547554 8290922 KLTH0B06798g Lachancea thermotolerans CBS 6340 KLTH0B06798p XP_002552083.1 546016 D 559295 CDS KLTH0B06820g 255711602 8290923 complement(547625..552751) 1 NC_013078.1 similar to uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase- Promoting Complex/Cyclosome (APC/C) which is a ubiquitin- protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0B06820p 552751 8290923 KLTH0B06820g Lachancea thermotolerans CBS 6340 KLTH0B06820p XP_002552084.1 547625 R 559295 CDS KLTH0B06864g 255711604 8290925 554835..557513 1 NC_013078.1 weakly similar to uniprot|P38845 Saccharomyces cerevisiae YHR146W CRP1 Protein that binds to cruciform DNA structures; KLTH0B06864p 557513 8290925 KLTH0B06864g Lachancea thermotolerans CBS 6340 KLTH0B06864p XP_002552085.1 554835 D 559295 CDS KLTH0B06886g 255711606 8290926 557856..559046 1 NC_013078.1 similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C; KLTH0B06886p 559046 8290926 KLTH0B06886g Lachancea thermotolerans CBS 6340 KLTH0B06886p XP_002552086.1 557856 D 559295 CDS KLTH0B06908g 255711608 8290927 559697..560776 1 NC_013078.1 weakly similar to uniprot|P53882 Saccharomyces cerevisiae YNL176C Hypothetical ORF; KLTH0B06908p 560776 8290927 KLTH0B06908g Lachancea thermotolerans CBS 6340 KLTH0B06908p XP_002552087.1 559697 D 559295 CDS KLTH0B06930g 255711610 8290928 560847..561848 1 NC_013078.1 similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit; KLTH0B06930p 561848 8290928 KLTH0B06930g Lachancea thermotolerans CBS 6340 KLTH0B06930p XP_002552088.1 560847 D 559295 CDS KLTH0B06952g 255711612 8290929 complement(561932..562537) 1 NC_013078.1 similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface; KLTH0B06952p 562537 8290929 KLTH0B06952g Lachancea thermotolerans CBS 6340 KLTH0B06952p XP_002552089.1 561932 R 559295 CDS KLTH0B06974g 255711614 8290930 complement(562821..563567) 1 NC_013078.1 highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit; KLTH0B06974p 563567 8290930 KLTH0B06974g Lachancea thermotolerans CBS 6340 KLTH0B06974p XP_002552090.1 562821 R 559295 CDS KLTH0B06996g 255711616 8290931 565363..566142 1 NC_013078.1 weakly similar to uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; KLTH0B06996p 566142 8290931 KLTH0B06996g Lachancea thermotolerans CBS 6340 KLTH0B06996p XP_002552091.1 565363 D 559295 CDS KLTH0B07018g 255711618 8290932 complement(566364..567581) 1 NC_013078.1 similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Protein required for cell viability; KLTH0B07018p 567581 8290932 KLTH0B07018g Lachancea thermotolerans CBS 6340 KLTH0B07018p XP_002552092.1 566364 R 559295 CDS KLTH0B07040g 255711620 8290933 567756..569276 1 NC_013078.1 similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Protein required for cell viability computational analysis of large-scale protein- protein interaction data suggests a possible role in assembly of the ribosomal large subunit; KLTH0B07040p 569276 8290933 KLTH0B07040g Lachancea thermotolerans CBS 6340 KLTH0B07040p XP_002552093.1 567756 D 559295 CDS KLTH0B07062g 255711622 8290934 complement(569322..569627) 1 NC_013078.1 conserved hypothetical protein; KLTH0B07062p 569627 8290934 KLTH0B07062g Lachancea thermotolerans CBS 6340 KLTH0B07062p XP_002552094.1 569322 R 559295 CDS KLTH0B07084g 255711624 8290935 569812..570441 1 NC_013078.1 some similarities with uniprot|Q07623 Saccharomyces cerevisiae YDL213C; KLTH0B07084p 570441 8290935 KLTH0B07084g Lachancea thermotolerans CBS 6340 KLTH0B07084p XP_002552095.1 569812 D 559295 CDS KLTH0B07106g 255711626 8290936 571005..573260 1 NC_013078.1 similar to uniprot|P22211 Saccharomyces cerevisiae YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; KLTH0B07106p 573260 8290936 KLTH0B07106g Lachancea thermotolerans CBS 6340 KLTH0B07106p XP_002552096.1 571005 D 559295 CDS KLTH0B07128g 255711628 8290937 573530..574060 1 NC_013078.1 highly similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit; KLTH0B07128p 574060 8290937 KLTH0B07128g Lachancea thermotolerans CBS 6340 KLTH0B07128p XP_002552097.1 573530 D 559295 CDS KLTH0B07150g 255711630 8290938 complement(574195..576465) 1 NC_013078.1 some similarities with uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties may regulate silencing by acting on Sir4p involved in posttranscriptionally regulating Gap1p and possibly other transporters primarily located in the nucleus; KLTH0B07150p 576465 8290938 KLTH0B07150g Lachancea thermotolerans CBS 6340 KLTH0B07150p XP_002552098.1 574195 R 559295 CDS KLTH0B07172g 255711632 8290939 578663..581806 1 NC_013078.1 similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD( )-dependent glutamate dehydrogenase degrades glutamate to ammonia and alpha- ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; KLTH0B07172p 581806 8290939 KLTH0B07172g Lachancea thermotolerans CBS 6340 KLTH0B07172p XP_002552099.1 578663 D 559295 CDS KLTH0B07194g 255711634 8290940 582064..583302 1 NC_013078.1 weakly similar to uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 subunit of COP9 signalosome (CSN) COP9 signalosome; KLTH0B07194p 583302 8290940 KLTH0B07194g Lachancea thermotolerans CBS 6340 KLTH0B07194p XP_002552100.1 582064 D 559295 CDS KLTH0B07216g 255711636 8290941 complement(583297..584565) 1 NC_013078.1 similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W Non-essential protein with putative leucine-rich nuclear export signal (NES) sequence that fits the consensus sequence recognized by Crm1p; KLTH0B07216p 584565 8290941 KLTH0B07216g Lachancea thermotolerans CBS 6340 KLTH0B07216p XP_002552101.1 583297 R 559295 CDS KLTH0B07238g 255711638 8290942 584739..585329 1 NC_013078.1 highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family; KLTH0B07238p 585329 8290942 KLTH0B07238g Lachancea thermotolerans CBS 6340 KLTH0B07238p XP_002552102.1 584739 D 559295 CDS KLTH0B07260g 255711640 8290943 complement(585375..586334) 1 NC_013078.1 conserved hypothetical protein; KLTH0B07260p 586334 8290943 KLTH0B07260g Lachancea thermotolerans CBS 6340 KLTH0B07260p XP_002552103.1 585375 R 559295 CDS KLTH0B07282g 255711642 8290944 complement(586628..588358) 1 NC_013078.1 highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 karyopherin alpha homolog of 60 kDa; KLTH0B07282p 588358 8290944 KLTH0B07282g Lachancea thermotolerans CBS 6340 KLTH0B07282p XP_002552104.1 586628 R 559295 CDS KLTH0B07304g 255711644 8290945 complement(588958..589548) 1 NC_013078.1 similar to uniprot|P53872 Saccharomyces cerevisiae YNL190W Hypothetical ORF; KLTH0B07304p 589548 8290945 KLTH0B07304g Lachancea thermotolerans CBS 6340 KLTH0B07304p XP_002552105.1 588958 R 559295 CDS KLTH0B07326g 255711646 8290946 complement(591369..592292) 1 NC_013078.1 weakly similar to uniprot|Q7LGR3 Saccharomyces cerevisiae YDL218W; KLTH0B07326p 592292 8290946 KLTH0B07326g Lachancea thermotolerans CBS 6340 KLTH0B07326p XP_002552106.1 591369 R 559295 CDS KLTH0B07348g 255711648 8290947 complement(join(593005..594050,594118..594142)) 1 NC_013078.1 highly similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W Hypothetical ORF; KLTH0B07348p 594142 8290947 KLTH0B07348g Lachancea thermotolerans CBS 6340 KLTH0B07348p XP_002552107.1 593005 R 559295 CDS KLTH0B07370g 255711650 8290948 complement(join(594459..594846,594905..594969)) 1 NC_013078.1 highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase functions in protein translation may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes; KLTH0B07370p 594969 8290948 KLTH0B07370g Lachancea thermotolerans CBS 6340 KLTH0B07370p XP_002552108.1 594459 R 559295 CDS KLTH0B07392g 255711652 8290949 complement(595129..598293) 1 NC_013078.1 similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I requires activation from zymogenic form in order to catalyze the transfer of N- acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor; KLTH0B07392p 598293 8290949 KLTH0B07392g Lachancea thermotolerans CBS 6340 KLTH0B07392p XP_002552109.1 595129 R 559295 CDS KLTH0B07414g 255711654 8290950 complement(598488..599999) 1 NC_013078.1 similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Hypothetical ORF; KLTH0B07414p 599999 8290950 KLTH0B07414g Lachancea thermotolerans CBS 6340 KLTH0B07414p XP_002552110.1 598488 R 559295 CDS KLTH0B07436g 255711656 8290951 600260..603043 1 NC_013078.1 some similarities with uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA- binding protein found at TG1-3 telomere G-tails regulates telomere replication through recruitment of specific sub- complexes but the essential function is telomere capping; KLTH0B07436p 603043 8290951 KLTH0B07436g Lachancea thermotolerans CBS 6340 KLTH0B07436p XP_002552111.1 600260 D 559295 CDS KLTH0B07480g 255711658 8290952 603685..604638 1 NC_013078.1 similar to uniprot|Q07651 Saccharomyces cerevisiae YDL222C FMP45 The authentic non-tagged protein was localized to the mitochondria cell cortex protein not required for growth on nonfermentable carbon sources required for viability in stationary phase; KLTH0B07480p 604638 8290952 KLTH0B07480g Lachancea thermotolerans CBS 6340 KLTH0B07480p XP_002552112.1 603685 D 559295 CDS KLTH0B07502g 255711660 8290953 join(604448..604460,604791..607777) 1 NC_013078.1 weakly similar to uniprot|Q07653 Saccharomyces cerevisiae YDL223C HBT1; KLTH0B07502p 607777 8290953 KLTH0B07502g Lachancea thermotolerans CBS 6340 KLTH0B07502p XP_002552113.1 604448 D 559295 CDS KLTH0B07524g 255711662 8290954 608293..608811 1 NC_013078.1 no similarity; KLTH0B07524p 608811 8290954 KLTH0B07524g Lachancea thermotolerans CBS 6340 KLTH0B07524p XP_002552114.1 608293 D 559295 CDS KLTH0B07546g 255711664 8290955 609954..611873 1 NC_013078.1 some similarities with Saccharomyces cerevisiae YDL224C WHI4 and to uniprot|P34761 Saccharomyces cerevisiae YNL197C WHI3; KLTH0B07546p 611873 8290955 KLTH0B07546g Lachancea thermotolerans CBS 6340 KLTH0B07546p XP_002552115.1 609954 D 559295 CDS KLTH0B07568g 255711666 8290956 complement(612453..614087) 1 NC_013078.1 similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; KLTH0B07568p 614087 8290956 KLTH0B07568g Lachancea thermotolerans CBS 6340 KLTH0B07568p XP_002552116.1 612453 R 559295 CDS KLTH0B07590g 255711668 8290957 615240..616430 1 NC_013078.1 weakly similar to uniprot|Q01722 Saccharomyces cerevisiae YNL199C GCR2 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr1p; KLTH0B07590p 616430 8290957 KLTH0B07590g Lachancea thermotolerans CBS 6340 KLTH0B07590p XP_002552117.1 615240 D 559295 CDS KLTH0B07612g 255711670 8290958 617509..618234 1 NC_013078.1 highly similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C; KLTH0B07612p 618234 8290958 KLTH0B07612g Lachancea thermotolerans CBS 6340 KLTH0B07612p XP_002552118.1 617509 D 559295 CDS KLTH0B07634g 255711672 8290959 618664..621033 1 NC_013078.1 similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Nuclear protein of unknown function deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C deletion is synthetically lethal with a chitin synthase (CHS1) null mutant; KLTH0B07634p 621033 8290959 KLTH0B07634g Lachancea thermotolerans CBS 6340 KLTH0B07634p XP_002552119.1 618664 D 559295 CDS KLTH0B07656g 255711674 8290960 complement(621077..621979) 1 NC_013078.1 highly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation peroxisomal 2 4-dienoyl-CoA reductase; KLTH0B07656p 621979 8290960 KLTH0B07656g Lachancea thermotolerans CBS 6340 KLTH0B07656p XP_002552120.1 621077 R 559295 CDS KLTH0B07678g 255711676 8290961 622309..623451 1 NC_013078.1 similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C GCS1 ADP-ribosylation factor GTPase activating protein; KLTH0B07678p 623451 8290961 KLTH0B07678g Lachancea thermotolerans CBS 6340 KLTH0B07678p XP_002552121.1 622309 D 559295 CDS KLTH0B07700g 255711678 8290962 623851..625155 1 NC_013078.1 weakly similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105 disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes.; KLTH0B07700p 625155 8290962 KLTH0B07700g Lachancea thermotolerans CBS 6340 KLTH0B07700p XP_002552122.1 623851 D 559295 CDS KLTH0B07722g 255711680 8290963 complement(625231..626517) 1 NC_013078.1 similar to uniprot|P40160 Saccharomyces cerevisiae YNL207W RIO2 Protein required for cell viability; KLTH0B07722p 626517 8290963 KLTH0B07722g Lachancea thermotolerans CBS 6340 KLTH0B07722p XP_002552123.1 625231 R 559295 CDS KLTH0B07744g 255711682 8290964 complement(628224..630065) 1 NC_013078.1 highly similar to uniprot|P40150 Saccharomyces cerevisiae YNL209W SSB2 Ribosome-associated molecular chaperone heat shock protein of HSP70 family proposed to be involved in the folding of newly synthesized polypeptide chains homolog of SSB1; KLTH0B07744p 630065 8290964 KLTH0B07744g Lachancea thermotolerans CBS 6340 KLTH0B07744p XP_002552124.1 628224 R 559295 CDS KLTH0B07766g 255711684 8290965 complement(630469..631470) 1 NC_013078.1 some similarities with uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA- binding motifs required for meiosis-specific mRNA splicing required for chromosome pairing and meiotic recombination; KLTH0B07766p 631470 8290965 KLTH0B07766g Lachancea thermotolerans CBS 6340 KLTH0B07766p XP_002552125.1 630469 R 559295 CDS KLTH0B07788g 255711686 8290966 complement(631704..632702) 1 NC_013078.1 similar to uniprot|P25044 Saccharomyces cerevisiae YDL230W PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo including Fpr3p localized to the cytoplasm and the mitochondria; KLTH0B07788p 632702 8290966 KLTH0B07788g Lachancea thermotolerans CBS 6340 KLTH0B07788p XP_002552126.1 631704 R 559295 CDS KLTH0B07810g 255711688 8290967 632854..636033 1 NC_013078.1 similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A a drug which is known to affect intracellular transport; KLTH0B07810p 636033 8290967 KLTH0B07810g Lachancea thermotolerans CBS 6340 KLTH0B07810p XP_002552127.1 632854 D 559295 CDS KLTH0B07832g 255711690 8290968 636698..636958 1 NC_013078.1 similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Hypothetical ORF; KLTH0B07832p 636958 8290968 KLTH0B07832g Lachancea thermotolerans CBS 6340 KLTH0B07832p XP_002552128.1 636698 D 559295 CDS KLTH0B07854g 255711692 8290969 complement(637131..639578) 1 NC_013078.1 similar to uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Vacuole import and degradation; KLTH0B07854p 639578 8290969 KLTH0B07854g Lachancea thermotolerans CBS 6340 KLTH0B07854p XP_002552129.1 637131 R 559295 CDS KLTH0B07876g 255711694 8290970 639886..640557 1 NC_013078.1 weakly similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C Hypothetical ORF; KLTH0B07876p 640557 8290970 KLTH0B07876g Lachancea thermotolerans CBS 6340 KLTH0B07876p XP_002552130.1 639886 D 559295 CDS KLTH0B07898g 255711696 8290971 complement(640619..641242) 1 NC_013078.1 similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane protein component of the peroxisomal translocation machinery required for peroxisome biogenesis binds Pex14p; KLTH0B07898p 641242 8290971 KLTH0B07898g Lachancea thermotolerans CBS 6340 KLTH0B07898p XP_002552131.1 640619 R 559295 CDS KLTH0B07920g 255711698 8290972 complement(641583..643160) 1 NC_013078.1 weakly similar to uniprot|Q07684 Saccharomyces cerevisiae YDL233W Hypothetical ORF; KLTH0B07920p 643160 8290972 KLTH0B07920g Lachancea thermotolerans CBS 6340 KLTH0B07920p XP_002552132.1 641583 R 559295 CDS KLTH0B07942g 255711700 8290973 complement(643482..644171) 1 NC_013078.1 some similarities with uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; KLTH0B07942p 644171 8290973 KLTH0B07942g Lachancea thermotolerans CBS 6340 KLTH0B07942p XP_002552133.1 643482 R 559295 CDS KLTH0B07964g 255711702 8290974 644343..646580 1 NC_013078.1 similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective) Ypt1p Ypt31p and Ypt32p (in vitro) involved in vesicle mediated protein trafficking; KLTH0B07964p 646580 8290974 KLTH0B07964g Lachancea thermotolerans CBS 6340 KLTH0B07964p XP_002552134.1 644343 D 559295 CDS KLTH0B07986g 255711704 8290975 complement(646727..648892) 1 NC_013078.1 similar to uniprot|P11938 Saccharomyces cerevisiae YNL216W RAP1 DNA-binding protein involved in either activation or repression of transcription depending on binding site context also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure; KLTH0B07986p 648892 8290975 KLTH0B07986g Lachancea thermotolerans CBS 6340 KLTH0B07986p XP_002552135.1 646727 R 559295 CDS KLTH0B08008g 255711706 8290976 complement(649859..650608) 1 NC_013078.1 weakly similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Hypothetical ORF; KLTH0B08008p 650608 8290976 KLTH0B08008g Lachancea thermotolerans CBS 6340 KLTH0B08008p XP_002552136.1 649859 R 559295 CDS KLTH0B08030g 255711708 8290977 652379..652795 1 NC_013078.1 similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; KLTH0B08030p 652795 8290977 KLTH0B08030g Lachancea thermotolerans CBS 6340 KLTH0B08030p XP_002552137.1 652379 D 559295 CDS KLTH0B08052g 255711710 8290978 complement(652928..654538) 1 NC_013078.1 similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome interacts functionally with DNA polymerase delta homolog of human Werner helicase interacting protein (WHIP); KLTH0B08052p 654538 8290978 KLTH0B08052g Lachancea thermotolerans CBS 6340 KLTH0B08052p XP_002552138.1 652928 R 559295 CDS KLTH0B08074g 255711712 8290979 complement(654730..655731) 1 NC_013078.1 similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p- nitrophenyl phosphate involved in dephosphorylation of histone II-A and casein; KLTH0B08074p 655731 8290979 KLTH0B08074g Lachancea thermotolerans CBS 6340 KLTH0B08074p XP_002552139.1 654730 R 559295 CDS KLTH0B08096g 255711714 8290980 655912..657567 1 NC_013078.1 similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 catalyzes the transfer of mannose from Dol-P- Man to lipid-linked oligosaccharides mannosyltransferase; KLTH0B08096p 657567 8290980 KLTH0B08096g Lachancea thermotolerans CBS 6340 KLTH0B08096p XP_002552140.1 655912 D 559295 CDS KLTH0B08118g 255711716 8290981 complement(657626..658930) 1 NC_013078.1 highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase catalyzes the first committed step in the 'de novo' biosynthesis of adenosine; KLTH0B08118p 658930 8290981 KLTH0B08118g Lachancea thermotolerans CBS 6340 KLTH0B08118p XP_002552141.1 657626 R 559295 CDS KLTH0B08140g 255711718 8290982 complement(659691..661397) 1 NC_013078.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma- aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane; KLTH0B08140p 661397 8290982 KLTH0B08140g Lachancea thermotolerans CBS 6340 KLTH0B08140p XP_002552142.1 659691 R 559295 CDS KLTH0B08162g 255711720 8290983 661997..664531 1 NC_013078.1 similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P; KLTH0B08162p 664531 8290983 KLTH0B08162g Lachancea thermotolerans CBS 6340 KLTH0B08162p XP_002552143.1 661997 D 559295 CDS KLTH0B08206g 255711722 8291089 complement(665390..666679) 1 NC_013078.1 similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W Hypothetical ORF; KLTH0B08206p 666679 8291089 KLTH0B08206g Lachancea thermotolerans CBS 6340 KLTH0B08206p XP_002552144.1 665390 R 559295 CDS KLTH0B08228g 255711724 8290985 667368..668792 1 NC_013078.1 similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine activity is low in exponentially- growing cultures but expression is increased in post- diauxic and stationary-phase cultures; KLTH0B08228p 668792 8290985 KLTH0B08228g Lachancea thermotolerans CBS 6340 KLTH0B08228p XP_002552145.1 667368 D 559295 CDS KLTH0B08250g 255711726 8290986 complement(668789..669409) 1 NC_013078.1 highly similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p exhibits intrinsic phosphatase activity affects start site selection in vivo Nuclear zinc-finger motif containing protein.; KLTH0B08250p 669409 8290986 KLTH0B08250g Lachancea thermotolerans CBS 6340 KLTH0B08250p XP_002552146.1 668789 R 559295 CDS KLTH0B08272g 255711728 8290987 complement(669610..671061) 1 NC_013078.1 similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p; KLTH0B08272p 671061 8290987 KLTH0B08272g Lachancea thermotolerans CBS 6340 KLTH0B08272p XP_002552147.1 669610 R 559295 CDS KLTH0B08294g 255711730 8290988 671104..673350 1 NC_013078.1 similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C Hypothetical ORF; KLTH0B08294p 673350 8290988 KLTH0B08294g Lachancea thermotolerans CBS 6340 KLTH0B08294p XP_002552148.1 671104 D 559295 CDS KLTH0B08316g 255711732 8290989 673602..676454 1 NC_013078.1 some similarities with uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene; KLTH0B08316p 676454 8290989 KLTH0B08316g Lachancea thermotolerans CBS 6340 KLTH0B08316p XP_002552149.1 673602 D 559295 CDS KLTH0B08338g 255711734 8290990 676591..678363 1 NC_013078.1 similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; KLTH0B08338p 678363 8290990 KLTH0B08338g Lachancea thermotolerans CBS 6340 KLTH0B08338p XP_002552150.1 676591 D 559295 CDS KLTH0B08360g 255711736 8290991 678693..679772 1 NC_013078.1 similar to uniprot|P23202 Saccharomyces cerevisiae YNL229C URE2 Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source altered form of Ure2p creates [URE3] prion; KLTH0B08360p 679772 8290991 KLTH0B08360g Lachancea thermotolerans CBS 6340 KLTH0B08360p XP_002552151.1 678693 D 559295 CDS KLTH0B08382g 255711738 8290992 680750..681883 1 NC_013078.1 some similarities with uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation; KLTH0B08382p 681883 8290992 KLTH0B08382g Lachancea thermotolerans CBS 6340 KLTH0B08382p XP_002552152.1 680750 D 559295 CDS KLTH0B08404g 255711740 8290993 682222..683262 1 NC_013078.1 highly similar to uniprot|P53860 Saccharomyces cerevisiae YNL231C PDR16 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p localizes to lipid particles and microsomes controls levels of various lipids may regulate lipid synthesis homologous to Pdr17p; KLTH0B08404p 683262 8290993 KLTH0B08404g Lachancea thermotolerans CBS 6340 KLTH0B08404p XP_002552153.1 682222 D 559295 CDS KLTH0B08426g 255711742 8290994 complement(683397..684242) 1 NC_013078.1 similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Subunit of the exosome which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation; KLTH0B08426p 684242 8290994 KLTH0B08426g Lachancea thermotolerans CBS 6340 KLTH0B08426p XP_002552154.1 683397 R 559295 CDS KLTH0B08448g 255711744 8290995 complement(684529..687123) 1 NC_013078.1 weakly similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase localized to the bud neck required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; KLTH0B08448p 687123 8290995 KLTH0B08448g Lachancea thermotolerans CBS 6340 KLTH0B08448p XP_002552155.1 684529 R 559295 CDS KLTH0B08470g 255711746 8290996 complement(687524..688819) 1 NC_013078.1 some similarities with uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p; KLTH0B08470p 688819 8290996 KLTH0B08470g Lachancea thermotolerans CBS 6340 KLTH0B08470p XP_002552156.1 687524 R 559295 CDS KLTH0B08492g 255711748 8290997 689075..691468 1 NC_013078.1 similar to uniprot|P38863 YHR172W Saccharomyces cerevisiae SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; KLTH0B08492p 691468 8290997 KLTH0B08492g Lachancea thermotolerans CBS 6340 KLTH0B08492p XP_002552157.1 689075 D 559295 CDS KLTH0B08514g 255711750 8290998 692293..693606 1 NC_013078.1 highly similar to uniprot|P00924 Saccharomyces cerevisiae YGR254W ENO1 Enolase I and to uniprot|P00925 Saccharomyces cerevisiae YHR174W ENO2 Enolase II; KLTH0B08514p 693606 8290998 KLTH0B08514g Lachancea thermotolerans CBS 6340 KLTH0B08514p XP_002552158.1 692293 D 559295 CDS KLTH0B08536g 255711752 8290999 693870..694322 1 NC_013078.1 similar to uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2; KLTH0B08536p 694322 8290999 KLTH0B08536g Lachancea thermotolerans CBS 6340 KLTH0B08536p XP_002552159.1 693870 D 559295 CDS KLTH0B08558g 255711754 8291000 694496..695806 1 NC_013078.1 similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins; KLTH0B08558p 695806 8291000 KLTH0B08558g Lachancea thermotolerans CBS 6340 KLTH0B08558p XP_002552160.1 694496 D 559295 CDS KLTH0B08580g 255711756 8291001 697066..698970 1 NC_013078.1 similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 binds Sin3p in two-hybrid assay Zinc finger (6-Cys); KLTH0B08580p 698970 8291001 KLTH0B08580g Lachancea thermotolerans CBS 6340 KLTH0B08580p XP_002552161.1 697066 D 559295 CDS KLTH0B08624g 255711758 8291003 699412..700092 1 NC_013078.1 highly similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Component of Sed5p vesicles; KLTH0B08624p 700092 8291003 KLTH0B08624g Lachancea thermotolerans CBS 6340 KLTH0B08624p XP_002552162.1 699412 D 559295 CDS KLTH0B08646g 255711760 8291004 700331..702544 1 NC_013078.1 weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; KLTH0B08646p 702544 8291004 KLTH0B08646g Lachancea thermotolerans CBS 6340 KLTH0B08646p XP_002552163.1 700331 D 559295 CDS KLTH0B08668g 255711762 8291005 703013..704491 1 NC_013078.1 highly similar to uniprot|P53319 Saccharomyces cerevisiae YGR256W GND2 and to uniprot|P38720 Saccharomyces cerevisiae YHR183W GND1 6-phosphogluconate dehydrogenase(decarboxylating); KLTH0B08668p 704491 8291005 KLTH0B08668g Lachancea thermotolerans CBS 6340 KLTH0B08668p XP_002552164.1 703013 D 559295 CDS KLTH0B08690g 255711764 8291006 704855..706639 1 NC_013078.1 weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and spore formation; KLTH0B08690p 706639 8291006 KLTH0B08690g Lachancea thermotolerans CBS 6340 KLTH0B08690p XP_002552165.1 704855 D 559295 CDS KLTH0B08712g 255711766 8291007 complement(706712..707746) 1 NC_013078.1 similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor; KLTH0B08712p 707746 8291007 KLTH0B08712g Lachancea thermotolerans CBS 6340 KLTH0B08712p XP_002552166.1 706712 R 559295 CDS KLTH0B08734g 255711768 8291008 complement(707994..708773) 1 NC_013078.1 weakly similar to uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein required for prospore membrane formation at selected spindle poles ensures functionality of all four spindle pole bodies of a cell during meiosis II not required for meiotic recombination or meiotic chromosome segregation; KLTH0B08734p 708773 8291008 KLTH0B08734g Lachancea thermotolerans CBS 6340 KLTH0B08734p XP_002552167.1 707994 R 559295 CDS KLTH0B08756g 255711770 8291009 complement(708976..712047) 1 NC_013078.1 similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein; KLTH0B08756p 712047 8291009 KLTH0B08756g Lachancea thermotolerans CBS 6340 KLTH0B08756p XP_002552168.1 708976 R 559295 CDS KLTH0B08800g 255711772 8291011 complement(712793..717340) 1 NC_013078.1 some similarities with uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1 a rapamycin- sensitive complex involved in growth control that contains Tor1p or Tor2p Lst8p and Tco89p contains four HEAT repeats and seven WD-40 repeats may act as a scaffold protein to couple TOR and its effectors; KLTH0B08800p 717340 8291011 KLTH0B08800g Lachancea thermotolerans CBS 6340 KLTH0B08800p XP_002552169.1 712793 R 559295 CDS KLTH0B08822g 255711774 8291012 717544..718431 1 NC_013078.1 similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of the Elp4p-Iki1p-Elp6p- subcomplex of RNA polymerase II elongator complex which is a histone acetyltransferase iki1 mutations confer resistance to the K. lactis toxin zymocin; KLTH0B08822p 718431 8291012 KLTH0B08822g Lachancea thermotolerans CBS 6340 KLTH0B08822p XP_002552170.1 717544 D 559295 CDS KLTH0B08844g 255711776 8291013 complement(718586..720562) 1 NC_013078.1 similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins human PIG-Tp homolog; KLTH0B08844p 720562 8291013 KLTH0B08844g Lachancea thermotolerans CBS 6340 KLTH0B08844p XP_002552171.1 718586 R 559295 CDS KLTH0B08866g 255711778 8291014 720807..723716 1 NC_013078.1 similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; KLTH0B08866p 723716 8291014 KLTH0B08866g Lachancea thermotolerans CBS 6340 KLTH0B08866p XP_002552172.1 720807 D 559295 CDS KLTH0B08888g 255711780 8291015 complement(723793..726174) 1 NC_013078.1 similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 beta3-like subunit of the yeast AP- 3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function putative beta adaptin component of the membrane-associate clathrin assembly complex; KLTH0B08888p 726174 8291015 KLTH0B08888g Lachancea thermotolerans CBS 6340 KLTH0B08888p XP_002552173.1 723793 R 559295 CDS KLTH0B08932g 255711782 8291017 726546..727685 1 NC_013078.1 similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 4-amino-4-deoxychorismate lyase catalyzes the third step in para-aminobenzoic acid biosynthesis; KLTH0B08932p 727685 8291017 KLTH0B08932g Lachancea thermotolerans CBS 6340 KLTH0B08932p XP_002552174.1 726546 D 559295 CDS KLTH0B08954g 255711784 8291018 complement(727687..728484) 1 NC_013078.1 similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0B08954p 728484 8291018 KLTH0B08954g Lachancea thermotolerans CBS 6340 KLTH0B08954p XP_002552175.1 727687 R 559295 CDS KLTH0B08976g 255711786 8291019 complement(729231..731486) 1 NC_013078.1 highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p which increases the catalytic efficiency of both tRNA synthetases also has a role in nuclear export of tRNAs; KLTH0B08976p 731486 8291019 KLTH0B08976g Lachancea thermotolerans CBS 6340 KLTH0B08976p XP_002552176.1 729231 R 559295 CDS KLTH0B08998g 255711788 8291020 complement(731722..733200) 1 NC_013078.1 highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase localizes to both the nuclear periphery and nucleolus highly enriched in nuclear pore complex fractions; KLTH0B08998p 733200 8291020 KLTH0B08998g Lachancea thermotolerans CBS 6340 KLTH0B08998p XP_002552177.1 731722 R 559295 CDS KLTH0B09020g 255711790 8291021 734001..736115 1 NC_013078.1 similar to uniprot|P53326 YGR266W Saccharomyces cerevisiae probably contains a single transmembrane span; KLTH0B09020p 736115 8291021 KLTH0B09020g Lachancea thermotolerans CBS 6340 KLTH0B09020p XP_002552178.1 734001 D 559295 CDS KLTH0B09042g 255711792 8291022 736520..738112 1 NC_013078.1 similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W Hypothetical ORF; KLTH0B09042p 738112 8291022 KLTH0B09042g Lachancea thermotolerans CBS 6340 KLTH0B09042p XP_002552179.1 736520 D 559295 CDS KLTH0B09064g 255711794 8291023 complement(738472..739206) 1 NC_013078.1 highly similar to uniprot|P51601 YGR267C Saccharomyces cerevisiae FOL2 GTP-cyclohydrolase I; KLTH0B09064p 739206 8291023 KLTH0B09064g Lachancea thermotolerans CBS 6340 KLTH0B09064p XP_002552180.1 738472 R 559295 CDS KLTH0B09086g 255711796 8291024 complement(740501..741178) 1 NC_013078.1 weakly similar to uniprot|P40325 YGR268C Saccharomyces cerevisiae HUA1 uncharacterized ORF; KLTH0B09086p 741178 8291024 KLTH0B09086g Lachancea thermotolerans CBS 6340 KLTH0B09086p XP_002552181.1 740501 R 559295 CDS KLTH0B09108g 255711798 8291025 join(741971..741992,742080..742474) 1 NC_013078.1 similar to uniprot|Q03554 YMR292w Saccharomyces cerevisiae GOT1 evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes; KLTH0B09108p 742474 8291025 KLTH0B09108g Lachancea thermotolerans CBS 6340 KLTH0B09108p XP_002552182.1 741971 D 559295 CDS KLTH0B09130g 255711800 8291026 742805..746806 1 NC_013078.1 similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein of unknown function member of CDC48/PAS1/SEC18 family of ATPases potentially phosphorylated by Cdc28p; KLTH0B09130p 746806 8291026 KLTH0B09130g Lachancea thermotolerans CBS 6340 KLTH0B09130p XP_002552183.1 742805 D 559295 CDS KLTH0B09152g 255711802 8291027 complement(746833..748230) 1 NC_013078.1 similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C Uncharacterized ORF; KLTH0B09152p 748230 8291027 KLTH0B09152g Lachancea thermotolerans CBS 6340 KLTH0B09152p XP_002552184.1 746833 R 559295 CDS KLTH0B09174g 255711804 8291028 748355..749449 1 NC_013078.1 weakly similar to uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex consisting of Nip100p Jnm1p and Arp1p required for proper nuclear migration and spindle partitioning during mitotic anaphase B; KLTH0B09174p 749449 8291028 KLTH0B09174g Lachancea thermotolerans CBS 6340 KLTH0B09174p XP_002552185.1 748355 D 559295 CDS KLTH0B09196g 255711806 8291029 749587..755451 1 NC_013078.1 highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 SKI2-like helicase; KLTH0B09196p 755451 8291029 KLTH0B09196g Lachancea thermotolerans CBS 6340 KLTH0B09196p XP_002552186.1 749587 D 559295 CDS KLTH0B09218g 255711808 8291030 complement(755504..756172) 1 NC_013078.1 similar to uniprot|P53328 YGR272C Saccharomyces cerevisiae Hypothetical ORF; KLTH0B09218p 756172 8291030 KLTH0B09218g Lachancea thermotolerans CBS 6340 KLTH0B09218p XP_002552187.1 755504 R 559295 CDS KLTH0B09240g 255711810 8291031 complement(756449..757042) 1 NC_013078.1 similar to uniprot|Q03559 YMR295C Saccharomyces cerevisiae Protein of unknown function; KLTH0B09240p 757042 8291031 KLTH0B09240g Lachancea thermotolerans CBS 6340 KLTH0B09240p XP_002552188.1 756449 R 559295 CDS KLTH0B09262g 255711812 8291032 758773..761235 1 NC_013078.1 weakly similar to uniprot|P39961 Saccharomyces cerevisiae YER184C Hypothetical ORF; KLTH0B09262p 761235 8291032 KLTH0B09262g Lachancea thermotolerans CBS 6340 KLTH0B09262p XP_002552189.1 758773 D 559295 CDS KLTH0B09284g 255711814 8291033 761694..762773 1 NC_013078.1 similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF and to YGR213C uniprot|P53047 Saccharomyces cerevisiae YGR213C RTA1 involved in 7- aminocholesterol resistance; KLTH0B09284p 762773 8291033 KLTH0B09284g Lachancea thermotolerans CBS 6340 KLTH0B09284p XP_002552190.1 761694 D 559295 CDS KLTH0B09306g 255711816 8291034 complement(762842..764500) 1 NC_013078.1 similar to uniprot|P25045 YMR296C Saccharomyces cerevisiae LCB1 Component of serine palmitoyltransferase responsible along with Lcb2p for the first committed step in sphingolipid synthesis; KLTH0B09306p 764500 8291034 KLTH0B09306g Lachancea thermotolerans CBS 6340 KLTH0B09306p XP_002552191.1 762842 R 559295 CDS KLTH0B09328g 255711818 8291035 765494..767071 1 NC_013078.1 similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C) involved in protein degradation in the vacuole and required for full protein degradation during sporulation; KLTH0B09328p 767071 8291035 KLTH0B09328g Lachancea thermotolerans CBS 6340 KLTH0B09328p XP_002552192.1 765494 D 559295 CDS KLTH0B09350g 255711820 8291036 767386..767808 1 NC_013078.1 similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W Protein required for cell viability; KLTH0B09350p 767808 8291036 KLTH0B09350g Lachancea thermotolerans CBS 6340 KLTH0B09350p XP_002552193.1 767386 D 559295 CDS KLTH0B09372g 255711822 8291037 complement(767865..770873) 1 NC_013078.1 similar to uniprot|P46677 YGR274C Saccharomyces cerevisiae TAF1 TFIID subunit (145 kDa) involved in RNA polymerase II transcription initiation; KLTH0B09372p 770873 8291037 KLTH0B09372g Lachancea thermotolerans CBS 6340 KLTH0B09372p XP_002552194.1 767865 R 559295 CDS KLTH0B09394g 255711824 8291038 771104..771655 1 NC_013078.1 weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Regulator of Ty1 Transposition regulator of Ty1 transposition; KLTH0B09394p 771655 8291038 KLTH0B09394g Lachancea thermotolerans CBS 6340 KLTH0B09394p XP_002552195.1 771104 D 559295 CDS KLTH0B09416g 255711826 8291039 complement(771758..773746) 1 NC_013078.1 similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3' exoribonuclease required for 5S and tRNA- Arg3 maturation; KLTH0B09416p 773746 8291039 KLTH0B09416g Lachancea thermotolerans CBS 6340 KLTH0B09416p XP_002552196.1 771758 R 559295 CDS KLTH0B09438g 255711828 8291040 complement(774127..775104) 1 NC_013078.1 weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC) localizes with dynein null mutant is defective in nuclear migration; KLTH0B09438p 775104 8291040 KLTH0B09438g Lachancea thermotolerans CBS 6340 KLTH0B09438p XP_002552197.1 774127 R 559295 CDS KLTH0B09460g 255711830 8291041 complement(775299..776831) 1 NC_013078.1 highly similar to uniprot|P04046 YMR300C Saccharomyces cerevisiae ADE4 Phosphoribosylpyrophosphate amidotransferase; KLTH0B09460p 776831 8291041 KLTH0B09460g Lachancea thermotolerans CBS 6340 KLTH0B09460p XP_002552198.1 775299 R 559295 CDS KLTH0B09482g 255711832 8291042 complement(777282..779366) 1 NC_013078.1 similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron- sulfur (Fe/S) clusters to the cytosol member of the ATP- binding cassette (ABC) transporter family; KLTH0B09482p 779366 8291042 KLTH0B09482g Lachancea thermotolerans CBS 6340 KLTH0B09482p XP_002552199.1 777282 R 559295 CDS KLTH0B09504g 255711834 8291043 complement(779619..780320) 1 NC_013078.1 highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 20S proteasome alpha-type subunit; KLTH0B09504p 780320 8291043 KLTH0B09504g Lachancea thermotolerans CBS 6340 KLTH0B09504p XP_002552200.1 779619 R 559295 CDS KLTH0B09526g 255711836 8291044 780915..782657 1 NC_013078.1 similar to uniprot|P40308 YMR313C Saccharomyces cerevisiae TGL3 Triacylglycerol lipase of the lipid particle; KLTH0B09526p 782657 8291044 KLTH0B09526g Lachancea thermotolerans CBS 6340 KLTH0B09526p XP_002552201.1 780915 D 559295 CDS KLTH0B09548g 255711838 8291045 complement(782708..783535) 1 NC_013078.1 similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity; KLTH0B09548p 783535 8291045 KLTH0B09548g Lachancea thermotolerans CBS 6340 KLTH0B09548p XP_002552202.1 782708 R 559295 CDS KLTH0B09570g 255711840 8291046 783747..785033 1 NC_013078.1 highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Cytosolic ribosome-associated chaperone contains a DnaJ domain together with Ssz1p acts as a chaperone for nascent polypeptide chains; KLTH0B09570p 785033 8291046 KLTH0B09570g Lachancea thermotolerans CBS 6340 KLTH0B09570p XP_002552203.1 783747 D 559295 CDS KLTH0B09592g 255711842 8291047 785306..786223 1 NC_013078.1 similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo; KLTH0B09592p 786223 8291047 KLTH0B09592g Lachancea thermotolerans CBS 6340 KLTH0B09592p XP_002552204.1 785306 D 559295 CDS KLTH0B09614g 255711844 8291048 786773..787390 1 NC_013078.1 similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p) involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2; KLTH0B09614p 787390 8291048 KLTH0B09614g Lachancea thermotolerans CBS 6340 KLTH0B09614p XP_002552205.1 786773 D 559295 CDS KLTH0B09636g 255711846 8291049 787602..788771 1 NC_013078.1 similar to uniprot|Q04867 Saccharomyces cerevisiae YMR310C Hypothetical ORF; KLTH0B09636p 788771 8291049 KLTH0B09636g Lachancea thermotolerans CBS 6340 KLTH0B09636p XP_002552206.1 787602 D 559295 CDS KLTH0B09658g 255711848 8291050 789016..789939 1 NC_013078.1 highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1 3-glucanase major protein of the cell wall involved in cell wall maintenance; KLTH0B09658p 789939 8291050 KLTH0B09658g Lachancea thermotolerans CBS 6340 KLTH0B09658p XP_002552207.1 789016 D 559295 CDS KLTH0B09680g 255711850 8291051 790481..792934 1 NC_013078.1 similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3) involved in the assembly of preinitiation complex and start codon selection; KLTH0B09680p 792934 8291051 KLTH0B09680g Lachancea thermotolerans CBS 6340 KLTH0B09680p XP_002552208.1 790481 D 559295 CDS KLTH0B09724g 255711852 8291053 complement(796023..800483) 1 NC_013078.1 similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane transporter of the ATP- binding cassette (ABC) family mediates export of many different organic anions including oligomycin; KLTH0B09724p 800483 8291053 KLTH0B09724g Lachancea thermotolerans CBS 6340 KLTH0B09724p XP_002552209.1 796023 R 559295 CDS KLTH0B09746g 255711854 8291054 complement(801412..803589) 1 NC_013078.1 some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; KLTH0B09746p 803589 8291054 KLTH0B09746g Lachancea thermotolerans CBS 6340 KLTH0B09746p XP_002552210.1 801412 R 559295 CDS KLTH0B09768g 255711856 8291055 805761..809039 1 NC_013078.1 similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p; KLTH0B09768p 809039 8291055 KLTH0B09768g Lachancea thermotolerans CBS 6340 KLTH0B09768p XP_002552211.1 805761 D 559295 CDS KLTH0B09790g 255711858 8291056 809351..810328 1 NC_013078.1 some similarities with uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability; KLTH0B09790p 810328 8291056 KLTH0B09790g Lachancea thermotolerans CBS 6340 KLTH0B09790p XP_002552212.1 809351 D 559295 CDS KLTH0B09812g 255711860 8291057 complement(810486..812117) 1 NC_013078.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; KLTH0B09812p 812117 8291057 KLTH0B09812g Lachancea thermotolerans CBS 6340 KLTH0B09812p XP_002552213.1 810486 R 559295 CDS KLTH0B09834g 255711862 8291058 complement(812816..814456) 1 NC_013078.1 similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; KLTH0B09834p 814456 8291058 KLTH0B09834g Lachancea thermotolerans CBS 6340 KLTH0B09834p XP_002552214.1 812816 R 559295 CDS KLTH0B09856g 255711864 8291059 complement(815242..820530) 1 NC_013078.1 similar to uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3 Protein of unknown function has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; KLTH0B09856p 820530 8291059 KLTH0B09856g Lachancea thermotolerans CBS 6340 KLTH0B09856p XP_002552215.1 815242 R 559295 CDS KLTH0B09878g 255711866 8291060 821778..822995 1 NC_013078.1 some similarities with uniprot|P53334 Saccharomyces cerevisiae YGR279C; KLTH0B09878p 822995 8291060 KLTH0B09878g Lachancea thermotolerans CBS 6340 KLTH0B09878p XP_002552216.1 821778 D 559295 CDS KLTH0B09900g 255711868 8291061 complement(823250..825040) 1 NC_013078.1 similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data; KLTH0B09900p 825040 8291061 KLTH0B09900g Lachancea thermotolerans CBS 6340 KLTH0B09900p XP_002552217.1 823250 R 559295 CDS KLTH0B09922g 255711870 8291062 825139..825996 1 NC_013078.1 similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT; KLTH0B09922p 825996 8291062 KLTH0B09922g Lachancea thermotolerans CBS 6340 KLTH0B09922p XP_002552218.1 825139 D 559295 CDS KLTH0B09944g 255711872 8291063 complement(826050..829619) 1 NC_013078.1 similar to uniprot|P50101 Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing; KLTH0B09944p 829619 8291063 KLTH0B09944g Lachancea thermotolerans CBS 6340 KLTH0B09944p XP_002552219.1 826050 R 559295 CDS KLTH0B09966g 255711874 8291064 831234..833657 1 NC_013078.1 similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases; KLTH0B09966p 833657 8291064 KLTH0B09966g Lachancea thermotolerans CBS 6340 KLTH0B09966p XP_002552220.1 831234 D 559295 CDS KLTH0B10032g 255711876 8291067 835039..838875 1 NC_013078.1 highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF; KLTH0B10032p 838875 8291067 KLTH0B10032g Lachancea thermotolerans CBS 6340 KLTH0B10032p XP_002552221.1 835039 D 559295 CDS KLTH0B10054g 255711878 8291068 complement(839166..840677) 1 NC_013078.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; KLTH0B10054p 840677 8291068 KLTH0B10054g Lachancea thermotolerans CBS 6340 KLTH0B10054p XP_002552222.1 839166 R 559295 CDS KLTH0B10076g 255711880 8291069 841024..843090 1 NC_013078.1 some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; KLTH0B10076p 843090 8291069 KLTH0B10076g Lachancea thermotolerans CBS 6340 KLTH0B10076p XP_002552223.1 841024 D 559295 CDS KLTH0B10098g 255711882 8291070 complement(843319..844122) 1 NC_013078.1 conserved hypothetical protein; KLTH0B10098p 844122 8291070 KLTH0B10098g Lachancea thermotolerans CBS 6340 KLTH0B10098p XP_002552224.1 843319 R 559295 CDS KLTH0B10142g 255711884 8291072 complement(847376..849082) 1 NC_013078.1 similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF; KLTH0B10142p 849082 8291072 KLTH0B10142g Lachancea thermotolerans CBS 6340 KLTH0B10142p XP_002552225.1 847376 R 559295 CDS KLTH0B10164g 255711886 8291073 complement(852039..852989) 1 NC_013078.1 conserved hypothetical protein; KLTH0B10164p 852989 8291073 KLTH0B10164g Lachancea thermotolerans CBS 6340 KLTH0B10164p XP_002552226.1 852039 R 559295 CDS KLTH0B10186g 255711888 8291074 855907..857637 1 NC_013078.1 highly similar to uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter active in early growth phase; KLTH0B10186p 857637 8291074 KLTH0B10186g Lachancea thermotolerans CBS 6340 KLTH0B10186p XP_002552227.1 855907 D 559295 CDS KLTH0B10230g 255711890 8291076 861584..862198 1 NC_013078.1 some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins; KLTH0B10230p 862198 8291076 KLTH0B10230g Lachancea thermotolerans CBS 6340 KLTH0B10230p XP_002552228.1 861584 D 559295 CDS KLTH0B10252g 255711892 8291077 863070..863741 1 NC_013078.1 some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins; KLTH0B10252p 863741 8291077 KLTH0B10252g Lachancea thermotolerans CBS 6340 KLTH0B10252p XP_002552229.1 863070 D 559295 CDS KLTH0B10274g 255711894 8291078 865279..865761 1 NC_013078.1 conserved hypothetical protein; KLTH0B10274p 865761 8291078 KLTH0B10274g Lachancea thermotolerans CBS 6340 KLTH0B10274p XP_002552230.1 865279 D 559295 CDS KLTH0B10296g 255711896 8291079 867082..867360 1 NC_013078.1 conserved hypothetical protein; KLTH0B10296p 867360 8291079 KLTH0B10296g Lachancea thermotolerans CBS 6340 KLTH0B10296p XP_002552231.1 867082 D 559295 CDS KLTH0B10318g 255711898 8291080 869187..873833 1 NC_013078.1 no similarity; KLTH0B10318p 873833 8291080 KLTH0B10318g Lachancea thermotolerans CBS 6340 KLTH0B10318p XP_002552232.1 869187 D 559295 CDS KLTH0B10340g 255711900 8291081 874656..875879 1 NC_013078.1 conserved hypothetical protein; KLTH0B10340p 875879 8291081 KLTH0B10340g Lachancea thermotolerans CBS 6340 KLTH0B10340p XP_002552233.1 874656 D 559295 CDS KLTH0B10384g 255711902 8291083 complement(877070..878725) 1 NC_013078.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression; KLTH0B10384p 878725 8291083 KLTH0B10384g Lachancea thermotolerans CBS 6340 KLTH0B10384p XP_002552234.1 877070 R 559295 CDS KLTH0B10428g 255711904 8291085 881360..885136 1 NC_013078.1 no similarity; KLTH0B10428p 885136 8291085 KLTH0B10428g Lachancea thermotolerans CBS 6340 KLTH0B10428p XP_002552235.1 881360 D 559295 CDS KLTH0B10450g 255711906 8291086 complement(885429..887291) 1 NC_013078.1 similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C; KLTH0B10450p 887291 8291086 KLTH0B10450g Lachancea thermotolerans CBS 6340 KLTH0B10450p XP_002552236.1 885429 R 559295 CDS KLTH0B10472g 255711908 8291087 888176..889927 1 NC_013078.1 conserved hypothetical protein; KLTH0B10472p 889927 8291087 KLTH0B10472g Lachancea thermotolerans CBS 6340 KLTH0B10472p XP_002552237.1 888176 D 559295 CDS KLTH0B10494g 255711910 8291088 complement(890670..892271) 1 NC_013078.1 conserved hypothetical protein; KLTH0B10494p 892271 8291088 KLTH0B10494g Lachancea thermotolerans CBS 6340 KLTH0B10494p XP_002552238.1 890670 R 559295 CDS KLTH0C00220g 255711913 8291096 complement(9795..10538) 1 NC_013079.1 similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Hypothetical ORF; KLTH0C00220p 10538 8291096 KLTH0C00220g Lachancea thermotolerans CBS 6340 KLTH0C00220p XP_002552239.1 9795 R 559295 CDS KLTH0C00264g 255711915 8291097 12563..12979 1 NC_013079.1 some similarities with uniprot|P53053 Saccharomyces cerevisiae YGL263W COS12 Protein of unknown function member of a family of conserved often subtelomerically- encoded proteins; KLTH0C00264p 12979 8291097 KLTH0C00264g Lachancea thermotolerans CBS 6340 KLTH0C00264p XP_002552240.1 12563 D 559295 CDS KLTH0C00286g 255711917 8291098 14835..16043 1 NC_013079.1 similar to uniprot|Q2TZW5 Aspergillus oryzae AO090011000693 Protein involved in biosynthesis of mitomycin antibiotics/polyketidefumonisin; KLTH0C00286p 16043 8291098 KLTH0C00286g Lachancea thermotolerans CBS 6340 KLTH0C00286p XP_002552241.1 14835 D 559295 CDS KLTH0C00330g 255711919 8291100 25162..26811 1 NC_013079.1 similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF; KLTH0C00330p 26811 8291100 KLTH0C00330g Lachancea thermotolerans CBS 6340 KLTH0C00330p XP_002552242.1 25162 D 559295 CDS KLTH0C00352g 255711921 8291101 complement(28541..30217) 1 NC_013079.1 similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF, memberof the Dal5p subfamily of the major facilitator family; KLTH0C00352p 30217 8291101 KLTH0C00352g Lachancea thermotolerans CBS 6340 KLTH0C00352p XP_002552243.1 28541 R 559295 CDS KLTH0C00374g 255711923 8291102 complement(32017..33147) 1 NC_013079.1 similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane responsible for the majority of zinc uptake transcription is induced under low-zinc conditions by the Zap1p transcription factor; KLTH0C00374p 33147 8291102 KLTH0C00374g Lachancea thermotolerans CBS 6340 KLTH0C00374p XP_002552244.1 32017 R 559295 CDS KLTH0C00396g 255711925 8291103 complement(33868..35277) 1 NC_013079.1 similar to uniprot|P00635 Saccharomyces cerevisiae YBR093C PHO5 One of three repressible acid phosphatases a glycoprotein that is transported to the cell surface by the secretory pathway induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; KLTH0C00396p 35277 8291103 KLTH0C00396g Lachancea thermotolerans CBS 6340 KLTH0C00396p XP_002552245.1 33868 R 559295 CDS KLTH0C00418g 255711927 8291104 38245..39039 1 NC_013079.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH; KLTH0C00418p 39039 8291104 KLTH0C00418g Lachancea thermotolerans CBS 6340 KLTH0C00418p XP_002552246.1 38245 D 559295 CDS KLTH0C00440g 255711929 8291105 complement(39458..47005) 1 NC_013079.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation; KLTH0C00440p 47005 8291105 KLTH0C00440g Lachancea thermotolerans CBS 6340 KLTH0C00440p XP_002552247.1 39458 R 559295 CDS KLTH0C00462g 255711931 8291106 complement(49362..51074) 1 NC_013079.1 highly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily expression is induced by low levels of glucose and repressed by high levels of glucose; KLTH0C00462p 51074 8291106 KLTH0C00462g Lachancea thermotolerans CBS 6340 KLTH0C00462p XP_002552248.1 49362 R 559295 CDS KLTH0C00484g 255711933 8291107 complement(52014..53858) 1 NC_013079.1 similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p- Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; KLTH0C00484p 53858 8291107 KLTH0C00484g Lachancea thermotolerans CBS 6340 KLTH0C00484p XP_002552249.1 52014 R 559295 CDS KLTH0C00506g 255711935 8291108 53979..54803 1 NC_013079.1 similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C or to uniprot|P40580 Saccharomyces cerevisiae YIR036C Hypothetical ORFs; KLTH0C00506p 54803 8291108 KLTH0C00506g Lachancea thermotolerans CBS 6340 KLTH0C00506p XP_002552250.1 53979 D 559295 CDS KLTH0C00528g 255711937 8291109 55308..56156 1 NC_013079.1 highly similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6; KLTH0C00528p 56156 8291109 KLTH0C00528g Lachancea thermotolerans CBS 6340 KLTH0C00528p XP_002552251.1 55308 D 559295 CDS KLTH0C00550g 255711939 8291110 56455..57318 1 NC_013079.1 conserved hypothetical protein; KLTH0C00550p 57318 8291110 KLTH0C00550g Lachancea thermotolerans CBS 6340 KLTH0C00550p XP_002552252.1 56455 D 559295 CDS KLTH0C00572g 255711941 8291111 complement(57378..59540) 1 NC_013079.1 similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation; KLTH0C00572p 59540 8291111 KLTH0C00572g Lachancea thermotolerans CBS 6340 KLTH0C00572p XP_002552253.1 57378 R 559295 CDS KLTH0C00594g 255711943 8291112 61284..62402 1 NC_013079.1 highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L- lysine-forming) catalyzes the conversion of saccharopine to L-lysine which is the final step in the lysine biosynthesis pathway; KLTH0C00594p 62402 8291112 KLTH0C00594g Lachancea thermotolerans CBS 6340 KLTH0C00594p XP_002552254.1 61284 D 559295 CDS KLTH0C00616g 255711945 8291113 complement(62501..63724) 1 NC_013079.1 similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta- transducin repeats; KLTH0C00616p 63724 8291113 KLTH0C00616g Lachancea thermotolerans CBS 6340 KLTH0C00616p XP_002552255.1 62501 R 559295 CDS KLTH0C00638g 255711947 8291114 complement(63995..67252) 1 NC_013079.1 similar to uniprot|P40578 Saccharomyces cerevisiae YIR033W MGA2 or to uniprot|P35210 Saccharomyces cerevisiae YKL020C SPT23, ER membrane proteins involved in regulation of OLE1 transcription; KLTH0C00638p 67252 8291114 KLTH0C00638g Lachancea thermotolerans CBS 6340 KLTH0C00638p XP_002552256.1 63995 R 559295 CDS KLTH0C00660g 255711949 8291115 68274..69221 1 NC_013079.1 similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit; KLTH0C00660p 69221 8291115 KLTH0C00660g Lachancea thermotolerans CBS 6340 KLTH0C00660p XP_002552257.1 68274 D 559295 CDS KLTH0C00682g 255711951 8291116 69344..70501 1 NC_013079.1 similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase; KLTH0C00682p 70501 8291116 KLTH0C00682g Lachancea thermotolerans CBS 6340 KLTH0C00682p XP_002552258.1 69344 D 559295 CDS KLTH0C00704g 255711953 8291117 complement(70539..71513) 1 NC_013079.1 some similarities with uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC) needed for meiotic nuclear division; KLTH0C00704p 71513 8291117 KLTH0C00704g Lachancea thermotolerans CBS 6340 KLTH0C00704p XP_002552259.1 70539 R 559295 CDS KLTH0C00726g 255711955 8291118 complement(71655..71891) 1 NC_013079.1 similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A; KLTH0C00726p 71891 8291118 KLTH0C00726g Lachancea thermotolerans CBS 6340 KLTH0C00726p XP_002552260.1 71655 R 559295 CDS KLTH0C00748g 255711957 8291119 72171..73157 1 NC_013079.1 highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; KLTH0C00748p 73157 8291119 KLTH0C00748g Lachancea thermotolerans CBS 6340 KLTH0C00748p XP_002552261.1 72171 D 559295 CDS KLTH0C00770g 255711959 8291120 complement(73182..75161) 1 NC_013079.1 similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha- associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities; KLTH0C00770p 75161 8291120 KLTH0C00770g Lachancea thermotolerans CBS 6340 KLTH0C00770p XP_002552262.1 73182 R 559295 CDS KLTH0C00792g 255711961 8291121 complement(75339..75863) 1 NC_013079.1 highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0C00792p 75863 8291121 KLTH0C00792g Lachancea thermotolerans CBS 6340 KLTH0C00792p XP_002552263.1 75339 R 559295 CDS KLTH0C00814g 255711963 8291122 76637..79141 1 NC_013079.1 similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; KLTH0C00814p 79141 8291122 KLTH0C00814g Lachancea thermotolerans CBS 6340 KLTH0C00814p XP_002552264.1 76637 D 559295 CDS KLTH0C00836g 255711965 8291123 complement(79382..84553) 1 NC_013079.1 similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit; KLTH0C00836p 84553 8291123 KLTH0C00836g Lachancea thermotolerans CBS 6340 KLTH0C00836p XP_002552265.1 79382 R 559295 CDS KLTH0C00858g 255711967 8291124 84727..85731 1 NC_013079.1 similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control; KLTH0C00858p 85731 8291124 KLTH0C00858g Lachancea thermotolerans CBS 6340 KLTH0C00858p XP_002552266.1 84727 D 559295 CDS KLTH0C00880g 255711969 8291125 complement(85841..89098) 1 NC_013079.1 similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; KLTH0C00880p 89098 8291125 KLTH0C00880g Lachancea thermotolerans CBS 6340 KLTH0C00880p XP_002552267.1 85841 R 559295 CDS KLTH0C00902g 255711971 8291126 complement(89610..90125) 1 NC_013079.1 highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; KLTH0C00902p 90125 8291126 KLTH0C00902g Lachancea thermotolerans CBS 6340 KLTH0C00902p XP_002552268.1 89610 R 559295 CDS KLTH0C00924g 255711973 8291127 90830..92524 1 NC_013079.1 similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex; KLTH0C00924p 92524 8291127 KLTH0C00924g Lachancea thermotolerans CBS 6340 KLTH0C00924p XP_002552269.1 90830 D 559295 CDS KLTH0C00946g 255711975 8291128 complement(92590..93096) 1 NC_013079.1 highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; KLTH0C00946p 93096 8291128 KLTH0C00946g Lachancea thermotolerans CBS 6340 KLTH0C00946p XP_002552270.1 92590 R 559295 CDS KLTH0C00968g 255711977 8291129 93347..94012 1 NC_013079.1 similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Hypothetical ORF; KLTH0C00968p 94012 8291129 KLTH0C00968g Lachancea thermotolerans CBS 6340 KLTH0C00968p XP_002552271.1 93347 D 559295 CDS KLTH0C00990g 255711979 8291130 complement(94049..95122) 1 NC_013079.1 similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease; KLTH0C00990p 95122 8291130 KLTH0C00990g Lachancea thermotolerans CBS 6340 KLTH0C00990p XP_002552272.1 94049 R 559295 CDS KLTH0C01012g 255711981 8291131 95515..96648 1 NC_013079.1 conserved hypothetical protein; KLTH0C01012p 96648 8291131 KLTH0C01012g Lachancea thermotolerans CBS 6340 KLTH0C01012p XP_002552273.1 95515 D 559295 CDS KLTH0C01034g 255711983 8291132 97077..98609 1 NC_013079.1 some similarities with uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability; KLTH0C01034p 98609 8291132 KLTH0C01034g Lachancea thermotolerans CBS 6340 KLTH0C01034p XP_002552274.1 97077 D 559295 CDS KLTH0C01056g 255711985 8291133 99846..102080 1 NC_013079.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381w FRE3 protein Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; KLTH0C01056p 102080 8291133 KLTH0C01056g Lachancea thermotolerans CBS 6340 KLTH0C01056p XP_002552275.1 99846 D 559295 CDS KLTH0C01078g 255711987 8291134 103368..103649 1 NC_013079.1 highly similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process; KLTH0C01078p 103649 8291134 KLTH0C01078g Lachancea thermotolerans CBS 6340 KLTH0C01078p XP_002552276.1 103368 D 559295 CDS KLTH0C01100g 255711989 8291135 complement(103757..104485) 1 NC_013079.1 similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1; KLTH0C01100p 104485 8291135 KLTH0C01100g Lachancea thermotolerans CBS 6340 KLTH0C01100p XP_002552277.1 103757 R 559295 CDS KLTH0C01122g 255711991 8291136 104968..106293 1 NC_013079.1 similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response activates the pathway via Scp160p; KLTH0C01122p 106293 8291136 KLTH0C01122g Lachancea thermotolerans CBS 6340 KLTH0C01122p XP_002552278.1 104968 D 559295 CDS KLTH0C01144g 255711993 8291137 106485..106904 1 NC_013079.1 similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes; KLTH0C01144p 106904 8291137 KLTH0C01144g Lachancea thermotolerans CBS 6340 KLTH0C01144p XP_002552279.1 106485 D 559295 CDS KLTH0C01166g 255711995 8291138 107662..108555 1 NC_013079.1 weakly similar to uniprot|Q08909 Saccharomyces cerevisiae YOR385W Hypothetical ORF; KLTH0C01166p 108555 8291138 KLTH0C01166g Lachancea thermotolerans CBS 6340 KLTH0C01166p XP_002552280.1 107662 D 559295 CDS KLTH0C01188g 255711997 8291139 110532..111533 1 NC_013079.1 highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle; KLTH0C01188p 111533 8291139 KLTH0C01188g Lachancea thermotolerans CBS 6340 KLTH0C01188p XP_002552281.1 110532 D 559295 CDS KLTH0C01210g 255711999 8291140 111667..112002 1 NC_013079.1 similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex; KLTH0C01210p 112002 8291140 KLTH0C01210g Lachancea thermotolerans CBS 6340 KLTH0C01210p XP_002552282.1 111667 D 559295 CDS KLTH0C01232g 255712001 8291141 complement(112021..113283) 1 NC_013079.1 similar to uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth; KLTH0C01232p 113283 8291141 KLTH0C01232g Lachancea thermotolerans CBS 6340 KLTH0C01232p XP_002552283.1 112021 R 559295 CDS KLTH0C01254g 255712003 8291142 complement(113435..114739) 1 NC_013079.1 conserved hypothetical protein; KLTH0C01254p 114739 8291142 KLTH0C01254g Lachancea thermotolerans CBS 6340 KLTH0C01254p XP_002552284.1 113435 R 559295 CDS KLTH0C01276g 255712005 8291143 114880..116118 1 NC_013079.1 weakly similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; KLTH0C01276p 116118 8291143 KLTH0C01276g Lachancea thermotolerans CBS 6340 KLTH0C01276p XP_002552285.1 114880 D 559295 CDS KLTH0C01298g 255712007 8291144 complement(116156..118810) 1 NC_013079.1 weakly similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration; KLTH0C01298p 118810 8291144 KLTH0C01298g Lachancea thermotolerans CBS 6340 KLTH0C01298p XP_002552286.1 116156 R 559295 CDS KLTH0C01320g 255712009 8291145 complement(119087..120466) 1 NC_013079.1 similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability; KLTH0C01320p 120466 8291145 KLTH0C01320g Lachancea thermotolerans CBS 6340 KLTH0C01320p XP_002552287.1 119087 R 559295 CDS KLTH0C01342g 255712011 8291146 join(122117..122324,122572..123611) 1 NC_013079.1 similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF- 1gamma; KLTH0C01342p 123611 8291146 KLTH0C01342g Lachancea thermotolerans CBS 6340 KLTH0C01342p XP_002552288.1 122117 D 559295 CDS KLTH0C01386g 255712013 8291624 123963..125141 1 NC_013079.1 highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector; KLTH0C01386p 125141 8291624 KLTH0C01386g Lachancea thermotolerans CBS 6340 KLTH0C01386p XP_002552289.1 123963 D 559295 CDS KLTH0C01408g 255712015 8291148 complement(125984..127537) 1 NC_013079.1 some similarities with uniprot|Q06150 Saccharomyces cerevisiae YLR267W BOP2 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation; KLTH0C01408p 127537 8291148 KLTH0C01408g Lachancea thermotolerans CBS 6340 KLTH0C01408p XP_002552290.1 125984 R 559295 CDS KLTH0C01430g 255712017 8291149 128670..129500 1 NC_013079.1 weakly similar to uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins; KLTH0C01430p 129500 8291149 KLTH0C01430g Lachancea thermotolerans CBS 6340 KLTH0C01430p XP_002552291.1 128670 D 559295 CDS KLTH0C01452g 255712019 8291150 complement(129587..130726) 1 NC_013079.1 some similarities with uniprot|P38854 Saccharomyces cerevisiae YHR159W Protein of unknown function that localizes to the cytoplasm potential Cdc28p substrate; KLTH0C01452p 130726 8291150 KLTH0C01452g Lachancea thermotolerans CBS 6340 KLTH0C01452p XP_002552292.1 129587 R 559295 CDS KLTH0C01474g 255712021 8291151 131243..134413 1 NC_013079.1 similar to uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate; KLTH0C01474p 134413 8291151 KLTH0C01474g Lachancea thermotolerans CBS 6340 KLTH0C01474p XP_002552293.1 131243 D 559295 CDS KLTH0C01496g 255712023 8291152 complement(134478..134948) 1 NC_013079.1 conserved hypothetical protein; KLTH0C01496p 134948 8291152 KLTH0C01496g Lachancea thermotolerans CBS 6340 KLTH0C01496p XP_002552294.1 134478 R 559295 CDS KLTH0C01518g 255712025 8291153 135506..137566 1 NC_013079.1 some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF; KLTH0C01518p 137566 8291153 KLTH0C01518g Lachancea thermotolerans CBS 6340 KLTH0C01518p XP_002552295.1 135506 D 559295 CDS KLTH0C01540g 255712027 8291154 138023..138460 1 NC_013079.1 conserved hypothetical protein; KLTH0C01540p 138460 8291154 KLTH0C01540g Lachancea thermotolerans CBS 6340 KLTH0C01540p XP_002552296.1 138023 D 559295 CDS KLTH0C01562g 255712029 8291155 138749..139441 1 NC_013079.1 similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF; KLTH0C01562p 139441 8291155 KLTH0C01562g Lachancea thermotolerans CBS 6340 KLTH0C01562p XP_002552297.1 138749 D 559295 CDS KLTH0C01584g 255712031 8291156 complement(139563..142304) 1 NC_013079.1 some similarities with uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing; KLTH0C01584p 142304 8291156 KLTH0C01584g Lachancea thermotolerans CBS 6340 KLTH0C01584p XP_002552298.1 139563 R 559295 CDS KLTH0C01628g 255712033 8291158 143303..146572 1 NC_013079.1 similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin- CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p; KLTH0C01628p 146572 8291158 KLTH0C01628g Lachancea thermotolerans CBS 6340 KLTH0C01628p XP_002552299.1 143303 D 559295 CDS KLTH0C01650g 255712035 8291159 complement(146654..147352) 1 NC_013079.1 similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; KLTH0C01650p 147352 8291159 KLTH0C01650g Lachancea thermotolerans CBS 6340 KLTH0C01650p XP_002552300.1 146654 R 559295 CDS KLTH0C01672g 255712037 8291160 147893..148816 1 NC_013079.1 highly similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p; KLTH0C01672p 148816 8291160 KLTH0C01672g Lachancea thermotolerans CBS 6340 KLTH0C01672p XP_002552301.1 147893 D 559295 CDS KLTH0C01694g 255712039 8291161 complement(149232..149483) 1 NC_013079.1 some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W; KLTH0C01694p 149483 8291161 KLTH0C01694g Lachancea thermotolerans CBS 6340 KLTH0C01694p XP_002552302.1 149232 R 559295 CDS KLTH0C01716g 255712041 8291162 154752..155870 1 NC_013079.1 conserved hypothetical protein; KLTH0C01716p 155870 8291162 KLTH0C01716g Lachancea thermotolerans CBS 6340 KLTH0C01716p XP_002552303.1 154752 D 559295 CDS KLTH0C01738g 255712043 8291163 158112..158345 1 NC_013079.1 no similarity; KLTH0C01738p 158345 8291163 KLTH0C01738g Lachancea thermotolerans CBS 6340 KLTH0C01738p XP_002552304.1 158112 D 559295 CDS KLTH0C01760g 255712045 8291164 158660..160210 1 NC_013079.1 similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein; KLTH0C01760p 160210 8291164 KLTH0C01760g Lachancea thermotolerans CBS 6340 KLTH0C01760p XP_002552305.1 158660 D 559295 CDS KLTH0C01782g 255712047 8291165 complement(160347..161861) 1 NC_013079.1 similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1; KLTH0C01782p 161861 8291165 KLTH0C01782g Lachancea thermotolerans CBS 6340 KLTH0C01782p XP_002552306.1 160347 R 559295 CDS KLTH0C01804g 255712049 8291166 162120..163631 1 NC_013079.1 weakly similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF; KLTH0C01804p 163631 8291166 KLTH0C01804g Lachancea thermotolerans CBS 6340 KLTH0C01804p XP_002552307.1 162120 D 559295 CDS KLTH0C01826g 255712051 8291167 complement(163729..165357) 1 NC_013079.1 similar to uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p; KLTH0C01826p 165357 8291167 KLTH0C01826g Lachancea thermotolerans CBS 6340 KLTH0C01826p XP_002552308.1 163729 R 559295 CDS KLTH0C01848g 255712053 8291168 complement(join(165526..166121,166518..167517)) 1 NC_013079.1 similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation; KLTH0C01848p 167517 8291168 KLTH0C01848g Lachancea thermotolerans CBS 6340 KLTH0C01848p XP_002552309.1 165526 R 559295 CDS KLTH0C01870g 255712055 8291169 168487..169758 1 NC_013079.1 similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5- bisphosphate- binding protein predicted to fold as a seven- bladed beta- propeller displays punctate cytoplasmic localization; KLTH0C01870p 169758 8291169 KLTH0C01870g Lachancea thermotolerans CBS 6340 KLTH0C01870p XP_002552310.1 168487 D 559295 CDS KLTH0C01892g 255712057 8291170 complement(169802..170770) 1 NC_013079.1 similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane; KLTH0C01892p 170770 8291170 KLTH0C01892g Lachancea thermotolerans CBS 6340 KLTH0C01892p XP_002552311.1 169802 R 559295 CDS KLTH0C01936g 255712059 8291628 171545..173581 1 NC_013079.1 weakly similar to uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate; KLTH0C01936p 173581 8291628 KLTH0C01936g Lachancea thermotolerans CBS 6340 KLTH0C01936p XP_002552312.1 171545 D 559295 CDS KLTH0C01958g 255712061 8291172 complement(173708..174259) 1 NC_013079.1 highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; KLTH0C01958p 174259 8291172 KLTH0C01958g Lachancea thermotolerans CBS 6340 KLTH0C01958p XP_002552313.1 173708 R 559295 CDS KLTH0C01980g 255712063 8291173 174934..175611 1 NC_013079.1 similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit; KLTH0C01980p 175611 8291173 KLTH0C01980g Lachancea thermotolerans CBS 6340 KLTH0C01980p XP_002552314.1 174934 D 559295 CDS KLTH0C02002g 255712065 8291174 175811..176617 1 NC_013079.1 similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit; KLTH0C02002p 176617 8291174 KLTH0C02002g Lachancea thermotolerans CBS 6340 KLTH0C02002p XP_002552315.1 175811 D 559295 CDS KLTH0C02024g 255712067 8291175 complement(176824..180078) 1 NC_013079.1 highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus; KLTH0C02024p 180078 8291175 KLTH0C02024g Lachancea thermotolerans CBS 6340 KLTH0C02024p XP_002552316.1 176824 R 559295 CDS KLTH0C02046g 255712069 8291176 complement(180744..186761) 1 NC_013079.1 similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones; KLTH0C02046p 186761 8291176 KLTH0C02046g Lachancea thermotolerans CBS 6340 KLTH0C02046p XP_002552317.1 180744 R 559295 CDS KLTH0C02068g 255712071 8291177 186916..188733 1 NC_013079.1 similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol; KLTH0C02068p 188733 8291177 KLTH0C02068g Lachancea thermotolerans CBS 6340 KLTH0C02068p XP_002552318.1 186916 D 559295 CDS KLTH0C02090g 255712073 8291178 complement(188861..189187) 1 NC_013079.1 similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit; KLTH0C02090p 189187 8291178 KLTH0C02090g Lachancea thermotolerans CBS 6340 KLTH0C02090p XP_002552319.1 188861 R 559295 CDS KLTH0C02112g 255712075 8291179 complement(join(189741..190406,190749..190838)) 1 NC_013079.1 highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit; KLTH0C02112p 190838 8291179 KLTH0C02112g Lachancea thermotolerans CBS 6340 KLTH0C02112p XP_002552320.1 189741 R 559295 CDS KLTH0C02134g 255712077 8291180 191811..193844 1 NC_013079.1 similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF; KLTH0C02134p 193844 8291180 KLTH0C02134g Lachancea thermotolerans CBS 6340 KLTH0C02134p XP_002552321.1 191811 D 559295 CDS KLTH0C02156g 255712079 8291181 complement(193918..196374) 1 NC_013079.1 weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W Hypothetical ORF; KLTH0C02156p 196374 8291181 KLTH0C02156g Lachancea thermotolerans CBS 6340 KLTH0C02156p XP_002552322.1 193918 R 559295 CDS KLTH0C02178g 255712081 8291182 complement(196605..197999) 1 NC_013079.1 weakly similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin; KLTH0C02178p 197999 8291182 KLTH0C02178g Lachancea thermotolerans CBS 6340 KLTH0C02178p XP_002552323.1 196605 R 559295 CDS KLTH0C02200g 255712083 8291183 complement(198184..199686) 1 NC_013079.1 highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p); KLTH0C02200p 199686 8291183 KLTH0C02200g Lachancea thermotolerans CBS 6340 KLTH0C02200p XP_002552324.1 198184 R 559295 CDS KLTH0C02244g 255712085 8291185 200556..201383 1 NC_013079.1 weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA involved in RNA splicing; KLTH0C02244p 201383 8291185 KLTH0C02244g Lachancea thermotolerans CBS 6340 KLTH0C02244p XP_002552325.1 200556 D 559295 CDS KLTH0C02266g 255712087 8291186 201515..203326 1 NC_013079.1 conserved hypothetical protein; KLTH0C02266p 203326 8291186 KLTH0C02266g Lachancea thermotolerans CBS 6340 KLTH0C02266p XP_002552326.1 201515 D 559295 CDS KLTH0C02288g 255712089 8291187 203725..204525 1 NC_013079.1 similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W Hypothetical ORF; KLTH0C02288p 204525 8291187 KLTH0C02288g Lachancea thermotolerans CBS 6340 KLTH0C02288p XP_002552327.1 203725 D 559295 CDS KLTH0C02310g 255712091 8291188 204734..205891 1 NC_013079.1 highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre- ribosomal particles; KLTH0C02310p 205891 8291188 KLTH0C02310g Lachancea thermotolerans CBS 6340 KLTH0C02310p XP_002552328.1 204734 D 559295 CDS KLTH0C02332g 255712093 8291189 complement(205933..206751) 1 NC_013079.1 similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C Hypothetical ORF; KLTH0C02332p 206751 8291189 KLTH0C02332g Lachancea thermotolerans CBS 6340 KLTH0C02332p XP_002552329.1 205933 R 559295 CDS KLTH0C02354g 255712095 8291190 207522..208490 1 NC_013079.1 highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C- terminal domain of Hyp2p (eIF5A) has four to five HEAT- like repeats; KLTH0C02354p 208490 8291190 KLTH0C02354g Lachancea thermotolerans CBS 6340 KLTH0C02354p XP_002552330.1 207522 D 559295 CDS KLTH0C02376g 255712097 8291191 208728..209315 1 NC_013079.1 similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N- hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis; KLTH0C02376p 209315 8291191 KLTH0C02376g Lachancea thermotolerans CBS 6340 KLTH0C02376p XP_002552331.1 208728 D 559295 CDS KLTH0C02398g 255712099 8291192 209869..213027 1 NC_013079.1 similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA; KLTH0C02398p 213027 8291192 KLTH0C02398g Lachancea thermotolerans CBS 6340 KLTH0C02398p XP_002552332.1 209869 D 559295 CDS KLTH0C02420g 255712101 8291193 213485..215191 1 NC_013079.1 weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein binds eIF4E and inhibits cap-dependent translation also functions independently of eIF4E to maintain genetic stability plays a role in cell growth implicated in the TOR signaling cascade; KLTH0C02420p 215191 8291193 KLTH0C02420g Lachancea thermotolerans CBS 6340 KLTH0C02420p XP_002552333.1 213485 D 559295 CDS KLTH0C02442g 255712103 8291194 complement(215254..216324) 1 NC_013079.1 highly similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; KLTH0C02442p 216324 8291194 KLTH0C02442g Lachancea thermotolerans CBS 6340 KLTH0C02442p XP_002552334.1 215254 R 559295 CDS KLTH0C02464g 255712105 8291195 216516..216989 1 NC_013079.1 similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function; KLTH0C02464p 216989 8291195 KLTH0C02464g Lachancea thermotolerans CBS 6340 KLTH0C02464p XP_002552335.1 216516 D 559295 CDS KLTH0C02486g 255712107 8291196 complement(217025..224428) 1 NC_013079.1 highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg; KLTH0C02486p 224428 8291196 KLTH0C02486g Lachancea thermotolerans CBS 6340 KLTH0C02486p XP_002552336.1 217025 R 559295 CDS KLTH0C02508g 255712109 8291197 224722..226077 1 NC_013079.1 highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity; KLTH0C02508p 226077 8291197 KLTH0C02508g Lachancea thermotolerans CBS 6340 KLTH0C02508p XP_002552337.1 224722 D 559295 CDS KLTH0C02530g 255712111 8291198 complement(226248..227930) 1 NC_013079.1 highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0C02530p 227930 8291198 KLTH0C02530g Lachancea thermotolerans CBS 6340 KLTH0C02530p XP_002552338.1 226248 R 559295 CDS KLTH0C02552g 255712113 8291199 complement(228167..228544) 1 NC_013079.1 highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex; KLTH0C02552p 228544 8291199 KLTH0C02552g Lachancea thermotolerans CBS 6340 KLTH0C02552p XP_002552339.1 228167 R 559295 CDS KLTH0C02574g 255712115 8291200 230316..233414 1 NC_013079.1 weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W Hypothetical ORF; KLTH0C02574p 233414 8291200 KLTH0C02574g Lachancea thermotolerans CBS 6340 KLTH0C02574p XP_002552340.1 230316 D 559295 CDS KLTH0C02596g 255712117 8291201 233983..235230 1 NC_013079.1 similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N- terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; KLTH0C02596p 235230 8291201 KLTH0C02596g Lachancea thermotolerans CBS 6340 KLTH0C02596p XP_002552341.1 233983 D 559295 CDS KLTH0C02618g 255712119 8291202 complement(235286..237994) 1 NC_013079.1 weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p) involved in mannosylphosphorylation of N-linked oligosaccharides expression increases in late-logarithmic and stationary growth phases; KLTH0C02618p 237994 8291202 KLTH0C02618g Lachancea thermotolerans CBS 6340 KLTH0C02618p XP_002552342.1 235286 R 559295 CDS KLTH0C02640g 255712121 8291203 complement(238703..239491) 1 NC_013079.1 some similarities with uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Helix-loop-helix protein that binds the motif CACRTG (R; KLTH0C02640p 239491 8291203 KLTH0C02640g Lachancea thermotolerans CBS 6340 KLTH0C02640p XP_002552343.1 238703 R 559295 CDS KLTH0C02662g 255712123 8291204 complement(240347..242674) 1 NC_013079.1 weakly similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake; KLTH0C02662p 242674 8291204 KLTH0C02662g Lachancea thermotolerans CBS 6340 KLTH0C02662p XP_002552344.1 240347 R 559295 CDS KLTH0C02684g 255712125 8291205 complement(242904..245963) 1 NC_013079.1 similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP- binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes; KLTH0C02684p 245963 8291205 KLTH0C02684g Lachancea thermotolerans CBS 6340 KLTH0C02684p XP_002552345.1 242904 R 559295 CDS KLTH0C02706g 255712127 8291206 246120..246563 1 NC_013079.1 highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin- associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin- associated protein (AP-2) complex; KLTH0C02706p 246563 8291206 KLTH0C02706g Lachancea thermotolerans CBS 6340 KLTH0C02706p XP_002552346.1 246120 D 559295 CDS KLTH0C02728g 255712129 8291207 complement(246560..247204) 1 NC_013079.1 similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p; KLTH0C02728p 247204 8291207 KLTH0C02728g Lachancea thermotolerans CBS 6340 KLTH0C02728p XP_002552347.1 246560 R 559295 CDS KLTH0C02772g 255712131 8291209 complement(248009..248497) 1 NC_013079.1 some similarities with uniprot|P50263 Saccharomyces cerevisiae YMR175W; KLTH0C02772p 248497 8291209 KLTH0C02772g Lachancea thermotolerans CBS 6340 KLTH0C02772p XP_002552348.1 248009 R 559295 CDS KLTH0C02794g 255712133 8291210 248746..249234 1 NC_013079.1 some similarities with uniprot|P47115 Saccharomyces cerevisiae YJR056C Hypothetical ORF; KLTH0C02794p 249234 8291210 KLTH0C02794g Lachancea thermotolerans CBS 6340 KLTH0C02794p XP_002552349.1 248746 D 559295 CDS KLTH0C02816g 255712135 8291211 250258..251133 1 NC_013079.1 similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Multicopy suppressor of rvs167 mutation putative integral membrane protein; KLTH0C02816p 251133 8291211 KLTH0C02816g Lachancea thermotolerans CBS 6340 KLTH0C02816p XP_002552350.1 250258 D 559295 CDS KLTH0C02838g 255712137 8291212 251842..253116 1 NC_013079.1 similar to uniprot|P04387 Saccharomyces cerevisiae YML051W GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose inhibits transcriptional activation by Gal4p inhibition relieved by Gal3p or Gal1p binding; KLTH0C02838p 253116 8291212 KLTH0C02838g Lachancea thermotolerans CBS 6340 KLTH0C02838p XP_002552351.1 251842 D 559295 CDS KLTH0C02860g 255712139 8291213 complement(253127..253594) 1 NC_013079.1 similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature; KLTH0C02860p 253594 8291213 KLTH0C02860g Lachancea thermotolerans CBS 6340 KLTH0C02860p XP_002552352.1 253127 R 559295 CDS KLTH0C02882g 255712141 8291214 253835..254833 1 NC_013079.1 similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W Hypothetical ORF; KLTH0C02882p 254833 8291214 KLTH0C02882g Lachancea thermotolerans CBS 6340 KLTH0C02882p XP_002552353.1 253835 D 559295 CDS KLTH0C02904g 255712143 8291215 complement(254875..258741) 1 NC_013079.1 similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing; KLTH0C02904p 258741 8291215 KLTH0C02904g Lachancea thermotolerans CBS 6340 KLTH0C02904p XP_002552354.1 254875 R 559295 CDS KLTH0C02926g 255712145 8291216 259431..260588 1 NC_013079.1 similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression; KLTH0C02926p 260588 8291216 KLTH0C02926g Lachancea thermotolerans CBS 6340 KLTH0C02926p XP_002552355.1 259431 D 559295 CDS KLTH0C02970g 255712147 8291218 complement(262224..263774) 1 NC_013079.1 some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate; KLTH0C02970p 263774 8291218 KLTH0C02970g Lachancea thermotolerans CBS 6340 KLTH0C02970p XP_002552356.1 262224 R 559295 CDS KLTH0C02992g 255712149 8291219 complement(264520..266127) 1 NC_013079.1 similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p- Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis; KLTH0C02992p 266127 8291219 KLTH0C02992g Lachancea thermotolerans CBS 6340 KLTH0C02992p XP_002552357.1 264520 R 559295 CDS KLTH0C03014g 255712151 8291220 266161..268185 1 NC_013079.1 similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats; KLTH0C03014p 268185 8291220 KLTH0C03014g Lachancea thermotolerans CBS 6340 KLTH0C03014p XP_002552358.1 266161 D 559295 CDS KLTH0C03036g 255712153 8291221 complement(268209..270011) 1 NC_013079.1 similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4); KLTH0C03036p 270011 8291221 KLTH0C03036g Lachancea thermotolerans CBS 6340 KLTH0C03036p XP_002552359.1 268209 R 559295 CDS KLTH0C03102g 255712155 8291224 271196..272773 1 NC_013079.1 conserved hypothetical protein; KLTH0C03102p 272773 8291224 KLTH0C03102g Lachancea thermotolerans CBS 6340 KLTH0C03102p XP_002552360.1 271196 D 559295 CDS KLTH0C03124g 255712157 8291225 complement(272830..273255) 1 NC_013079.1 similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF; KLTH0C03124p 273255 8291225 KLTH0C03124g Lachancea thermotolerans CBS 6340 KLTH0C03124p XP_002552361.1 272830 R 559295 CDS KLTH0C03146g 255712159 8291226 complement(273504..275009) 1 NC_013079.1 similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C Fumurate ReDuctase Soluble; KLTH0C03146p 275009 8291226 KLTH0C03146g Lachancea thermotolerans CBS 6340 KLTH0C03146p XP_002552362.1 273504 R 559295 CDS KLTH0C03168g 255712161 8291227 complement(275449..276714) 1 NC_013079.1 highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis; KLTH0C03168p 276714 8291227 KLTH0C03168g Lachancea thermotolerans CBS 6340 KLTH0C03168p XP_002552363.1 275449 R 559295 CDS KLTH0C03190g 255712163 8291228 277658..278062 1 NC_013079.1 similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; KLTH0C03190p 278062 8291228 KLTH0C03190g Lachancea thermotolerans CBS 6340 KLTH0C03190p XP_002552364.1 277658 D 559295 CDS KLTH0C03212g 255712165 8291229 279223..279819 1 NC_013079.1 highly similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Hypothetical ORF; KLTH0C03212p 279819 8291229 KLTH0C03212g Lachancea thermotolerans CBS 6340 KLTH0C03212p XP_002552365.1 279223 D 559295 CDS KLTH0C03234g 255712167 8291230 280513..282954 1 NC_013079.1 weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W Hypothetical ORF; KLTH0C03234p 282954 8291230 KLTH0C03234g Lachancea thermotolerans CBS 6340 KLTH0C03234p XP_002552366.1 280513 D 559295 CDS KLTH0C03256g 255712169 8291231 complement(283032..283832) 1 NC_013079.1 similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest; KLTH0C03256p 283832 8291231 KLTH0C03256g Lachancea thermotolerans CBS 6340 KLTH0C03256p XP_002552367.1 283032 R 559295 CDS KLTH0C03278g 255712171 8291232 285155..286954 1 NC_013079.1 similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2; KLTH0C03278p 286954 8291232 KLTH0C03278g Lachancea thermotolerans CBS 6340 KLTH0C03278p XP_002552368.1 285155 D 559295 CDS KLTH0C03300g 255712173 8291233 287614..289185 1 NC_013079.1 similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate; KLTH0C03300p 289185 8291233 KLTH0C03300g Lachancea thermotolerans CBS 6340 KLTH0C03300p XP_002552369.1 287614 D 559295 CDS KLTH0C03322g 255712175 8291234 289514..291112 1 NC_013079.1 similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p); KLTH0C03322p 291112 8291234 KLTH0C03322g Lachancea thermotolerans CBS 6340 KLTH0C03322p XP_002552370.1 289514 D 559295 CDS KLTH0C03344g 255712177 8291235 291335..292738 1 NC_013079.1 similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance; KLTH0C03344p 292738 8291235 KLTH0C03344g Lachancea thermotolerans CBS 6340 KLTH0C03344p XP_002552371.1 291335 D 559295 CDS KLTH0C03366g 255712179 8291236 complement(293119..293451) 1 NC_013079.1 highly similar to uniprot|P00044 Saccharomyces cerevisiae CYC1 Cytochrome c isoform 1 and to YEL039C uniprot|P00045 Saccharomyces cerevisiae CYC7 Cytochrome c isoform 2; KLTH0C03366p 293451 8291236 KLTH0C03366g Lachancea thermotolerans CBS 6340 KLTH0C03366p XP_002552372.1 293119 R 559295 CDS KLTH0C03388g 255712181 8291237 294499..295200 1 NC_013079.1 similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus; KLTH0C03388p 295200 8291237 KLTH0C03388g Lachancea thermotolerans CBS 6340 KLTH0C03388p XP_002552373.1 294499 D 559295 CDS KLTH0C03410g 255712183 8291238 complement(295299..296474) 1 NC_013079.1 similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23; KLTH0C03410p 296474 8291238 KLTH0C03410g Lachancea thermotolerans CBS 6340 KLTH0C03410p XP_002552374.1 295299 R 559295 CDS KLTH0C03432g 255712185 8291239 complement(297214..298683) 1 NC_013079.1 similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex; KLTH0C03432p 298683 8291239 KLTH0C03432g Lachancea thermotolerans CBS 6340 KLTH0C03432p XP_002552375.1 297214 R 559295 CDS KLTH0C03476g 255712187 8291240 300040..300513 1 NC_013079.1 highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A; KLTH0C03476p 300513 8291240 KLTH0C03476g Lachancea thermotolerans CBS 6340 KLTH0C03476p XP_002552376.1 300040 D 559295 CDS KLTH0C03498g 255712189 8291241 300823..301584 1 NC_013079.1 conserved hypothetical protein; KLTH0C03498p 301584 8291241 KLTH0C03498g Lachancea thermotolerans CBS 6340 KLTH0C03498p XP_002552377.1 300823 D 559295 CDS KLTH0C03520g 255712191 8291242 301635..304619 1 NC_013079.1 similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; KLTH0C03520p 304619 8291242 KLTH0C03520g Lachancea thermotolerans CBS 6340 KLTH0C03520p XP_002552378.1 301635 D 559295 CDS KLTH0C03542g 255712193 8291243 305204..308830 1 NC_013079.1 highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase; KLTH0C03542p 308830 8291243 KLTH0C03542g Lachancea thermotolerans CBS 6340 KLTH0C03542p XP_002552379.1 305204 D 559295 CDS KLTH0C03564g 255712195 8291244 complement(308883..310586) 1 NC_013079.1 similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication); KLTH0C03564p 310586 8291244 KLTH0C03564g Lachancea thermotolerans CBS 6340 KLTH0C03564p XP_002552380.1 308883 R 559295 CDS KLTH0C03586g 255712197 8291245 311969..313705 1 NC_013079.1 similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes; KLTH0C03586p 313705 8291245 KLTH0C03586g Lachancea thermotolerans CBS 6340 KLTH0C03586p XP_002552381.1 311969 D 559295 CDS KLTH0C03608g 255712199 8291246 complement(313729..315216) 1 NC_013079.1 similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C; KLTH0C03608p 315216 8291246 KLTH0C03608g Lachancea thermotolerans CBS 6340 KLTH0C03608p XP_002552382.1 313729 R 559295 CDS KLTH0C03630g 255712201 8291247 315520..315774 1 NC_013079.1 similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit; KLTH0C03630p 315774 8291247 KLTH0C03630g Lachancea thermotolerans CBS 6340 KLTH0C03630p XP_002552383.1 315520 D 559295 CDS KLTH0C03652g 255712203 8291248 complement(315850..316680) 1 NC_013079.1 conserved hypothetical protein; KLTH0C03652p 316680 8291248 KLTH0C03652g Lachancea thermotolerans CBS 6340 KLTH0C03652p XP_002552384.1 315850 R 559295 CDS KLTH0C03674g 255712205 8291249 complement(317119..319965) 1 NC_013079.1 similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs; KLTH0C03674p 319965 8291249 KLTH0C03674g Lachancea thermotolerans CBS 6340 KLTH0C03674p XP_002552385.1 317119 R 559295 CDS KLTH0C03696g 255712207 8291250 320129..321553 1 NC_013079.1 similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase; KLTH0C03696p 321553 8291250 KLTH0C03696g Lachancea thermotolerans CBS 6340 KLTH0C03696p XP_002552386.1 320129 D 559295 CDS KLTH0C03718g 255712209 8291251 321675..323330 1 NC_013079.1 weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'- untranslated leader; KLTH0C03718p 323330 8291251 KLTH0C03718g Lachancea thermotolerans CBS 6340 KLTH0C03718p XP_002552387.1 321675 D 559295 CDS KLTH0C03740g 255712211 8291252 complement(323371..324135) 1 NC_013079.1 weakly similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de-N-acetylation of the N- acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp; KLTH0C03740p 324135 8291252 KLTH0C03740g Lachancea thermotolerans CBS 6340 KLTH0C03740p XP_002552388.1 323371 R 559295 CDS KLTH0C03762g 255712213 8291253 324666..328286 1 NC_013079.1 similar to uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator; KLTH0C03762p 328286 8291253 KLTH0C03762g Lachancea thermotolerans CBS 6340 KLTH0C03762p XP_002552389.1 324666 D 559295 CDS KLTH0C03784g 255712215 8291254 328834..331827 1 NC_013079.1 similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data; KLTH0C03784p 331827 8291254 KLTH0C03784g Lachancea thermotolerans CBS 6340 KLTH0C03784p XP_002552390.1 328834 D 559295 CDS KLTH0C03806g 255712217 8291255 332195..333772 1 NC_013079.1 similar to uniprot|P13090 Saccharomyces cerevisiae YML116W ATR1 Multidrug efflux pump of the major facilitator superfamily required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; KLTH0C03806p 333772 8291255 KLTH0C03806g Lachancea thermotolerans CBS 6340 KLTH0C03806p XP_002552391.1 332195 D 559295 CDS KLTH0C03828g 255712219 8291256 complement(334500..335714) 1 NC_013079.1 similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N- glycosylation; KLTH0C03828p 335714 8291256 KLTH0C03828g Lachancea thermotolerans CBS 6340 KLTH0C03828p XP_002552392.1 334500 R 559295 CDS KLTH0C03850g 255712221 8291257 complement(336417..337406) 1 NC_013079.1 highly similar to uniprot|Q08985 Saccharomyces cerevisiae YPL273W SAM4 S-adenosylmethionine-homocysteine methyltransferase functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; KLTH0C03850p 337406 8291257 KLTH0C03850g Lachancea thermotolerans CBS 6340 KLTH0C03850p XP_002552393.1 336417 R 559295 CDS KLTH0C03872g 255712223 8291258 complement(337765..339630) 1 NC_013079.1 similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF; KLTH0C03872p 339630 8291258 KLTH0C03872g Lachancea thermotolerans CBS 6340 KLTH0C03872p XP_002552394.1 337765 R 559295 CDS KLTH0C03894g 255712225 8291259 complement(339897..342134) 1 NC_013079.1 similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase; KLTH0C03894p 342134 8291259 KLTH0C03894g Lachancea thermotolerans CBS 6340 KLTH0C03894p XP_002552395.1 339897 R 559295 CDS KLTH0C03916g 255712227 8291260 complement(342430..344142) 1 NC_013079.1 weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation; KLTH0C03916p 344142 8291260 KLTH0C03916g Lachancea thermotolerans CBS 6340 KLTH0C03916p XP_002552396.1 342430 R 559295 CDS KLTH0C03938g 255712229 8291261 complement(344354..345484) 1 NC_013079.1 some similarities with uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome; KLTH0C03938p 345484 8291261 KLTH0C03938g Lachancea thermotolerans CBS 6340 KLTH0C03938p XP_002552397.1 344354 R 559295 CDS KLTH0C03960g 255712231 8291262 346440..347108 1 NC_013079.1 weakly similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; KLTH0C03960p 347108 8291262 KLTH0C03960g Lachancea thermotolerans CBS 6340 KLTH0C03960p XP_002552398.1 346440 D 559295 CDS KLTH0C03982g 255712233 8291263 347354..348259 1 NC_013079.1 similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; KLTH0C03982p 348259 8291263 KLTH0C03982g Lachancea thermotolerans CBS 6340 KLTH0C03982p XP_002552399.1 347354 D 559295 CDS KLTH0C04004g 255712235 8291264 348548..351199 1 NC_013079.1 similar to uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3- ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1; KLTH0C04004p 351199 8291264 KLTH0C04004g Lachancea thermotolerans CBS 6340 KLTH0C04004p XP_002552400.1 348548 D 559295 CDS KLTH0C04026g 255712237 8291265 351697..352644 1 NC_013079.1 similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease; KLTH0C04026p 352644 8291265 KLTH0C04026g Lachancea thermotolerans CBS 6340 KLTH0C04026p XP_002552401.1 351697 D 559295 CDS KLTH0C04048g 255712239 8291266 352955..355762 1 NC_013079.1 similar to uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p; KLTH0C04048p 355762 8291266 KLTH0C04048g Lachancea thermotolerans CBS 6340 KLTH0C04048p XP_002552402.1 352955 D 559295 CDS KLTH0C04070g 255712241 8291267 355923..356264 1 NC_013079.1 similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha- beta sandwiches.; KLTH0C04070p 356264 8291267 KLTH0C04070g Lachancea thermotolerans CBS 6340 KLTH0C04070p XP_002552403.1 355923 D 559295 CDS KLTH0C04114g 255712243 8291269 357195..358331 1 NC_013079.1 highly similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme; KLTH0C04114p 358331 8291269 KLTH0C04114g Lachancea thermotolerans CBS 6340 KLTH0C04114p XP_002552404.1 357195 D 559295 CDS KLTH0C04136g 255712245 8291270 complement(358455..359393) 1 NC_013079.1 weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; KLTH0C04136p 359393 8291270 KLTH0C04136g Lachancea thermotolerans CBS 6340 KLTH0C04136p XP_002552405.1 358455 R 559295 CDS KLTH0C04158g 255712247 8291271 359809..360483 1 NC_013079.1 highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1; KLTH0C04158p 360483 8291271 KLTH0C04158g Lachancea thermotolerans CBS 6340 KLTH0C04158p XP_002552406.1 359809 D 559295 CDS KLTH0C04180g 255712249 8291272 complement(360879..361646) 1 NC_013079.1 similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19; KLTH0C04180p 361646 8291272 KLTH0C04180g Lachancea thermotolerans CBS 6340 KLTH0C04180p XP_002552407.1 360879 R 559295 CDS KLTH0C04202g 255712251 8291273 361915..363057 1 NC_013079.1 similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit; KLTH0C04202p 363057 8291273 KLTH0C04202g Lachancea thermotolerans CBS 6340 KLTH0C04202p XP_002552408.1 361915 D 559295 CDS KLTH0C04224g 255712253 8291274 complement(363016..366363) 1 NC_013079.1 weakly similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds; KLTH0C04224p 366363 8291274 KLTH0C04224g Lachancea thermotolerans CBS 6340 KLTH0C04224p XP_002552409.1 363016 R 559295 CDS KLTH0C04246g 255712255 8291275 complement(367003..367701) 1 NC_013079.1 some similarities with uniprot|Q03525 Saccharomyces cerevisiae YMR269W Nucleolar protein of unknown function; KLTH0C04246p 367701 8291275 KLTH0C04246g Lachancea thermotolerans CBS 6340 KLTH0C04246p XP_002552410.1 367003 R 559295 CDS KLTH0C04268g 255712257 8291276 367879..369231 1 NC_013079.1 similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling; KLTH0C04268p 369231 8291276 KLTH0C04268g Lachancea thermotolerans CBS 6340 KLTH0C04268p XP_002552411.1 367879 D 559295 CDS KLTH0C04290g 255712259 8291277 complement(369283..374151) 1 NC_013079.1 similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC); KLTH0C04290p 374151 8291277 KLTH0C04290g Lachancea thermotolerans CBS 6340 KLTH0C04290p XP_002552412.1 369283 R 559295 CDS KLTH0C04312g 255712261 8291278 complement(374543..375460) 1 NC_013079.1 similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; KLTH0C04312p 375460 8291278 KLTH0C04312g Lachancea thermotolerans CBS 6340 KLTH0C04312p XP_002552413.1 374543 R 559295 CDS KLTH0C04334g 255712263 8291279 complement(375721..378420) 1 NC_013079.1 similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein.; KLTH0C04334p 378420 8291279 KLTH0C04334g Lachancea thermotolerans CBS 6340 KLTH0C04334p XP_002552414.1 375721 R 559295 CDS KLTH0C04356g 255712265 8291280 379281..380711 1 NC_013079.1 weakly similar to uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF; KLTH0C04356p 380711 8291280 KLTH0C04356g Lachancea thermotolerans CBS 6340 KLTH0C04356p XP_002552415.1 379281 D 559295 CDS KLTH0C04378g 255712267 8291281 381355..382860 1 NC_013079.1 similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans; KLTH0C04378p 382860 8291281 KLTH0C04378g Lachancea thermotolerans CBS 6340 KLTH0C04378p XP_002552416.1 381355 D 559295 CDS KLTH0C04400g 255712269 8291282 complement(383002..383586) 1 NC_013079.1 similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; KLTH0C04400p 383586 8291282 KLTH0C04400g Lachancea thermotolerans CBS 6340 KLTH0C04400p XP_002552417.1 383002 R 559295 CDS KLTH0C04422g 255712271 8291283 complement(385542..386348) 1 NC_013079.1 weakly similar to uniprot|P53133 Saccharomyces cerevisiae YGL117W Hypothetical ORF; KLTH0C04422p 386348 8291283 KLTH0C04422g Lachancea thermotolerans CBS 6340 KLTH0C04422p XP_002552418.1 385542 R 559295 CDS KLTH0C04444g 255712273 8291284 complement(387195..387707) 1 NC_013079.1 similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci; KLTH0C04444p 387707 8291284 KLTH0C04444g Lachancea thermotolerans CBS 6340 KLTH0C04444p XP_002552419.1 387195 R 559295 CDS KLTH0C04466g 255712275 8291285 complement(387790..388725) 1 NC_013079.1 similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF; KLTH0C04466p 388725 8291285 KLTH0C04466g Lachancea thermotolerans CBS 6340 KLTH0C04466p XP_002552420.1 387790 R 559295 CDS KLTH0C04488g 255712277 8291286 388986..392303 1 NC_013079.1 similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6- phosphate synthase/phosphatase complex and to YML100W uniprot|P38427 Saccharomyces cerevisiae YML100W TSL1 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product; KLTH0C04488p 392303 8291286 KLTH0C04488g Lachancea thermotolerans CBS 6340 KLTH0C04488p XP_002552421.1 388986 D 559295 CDS KLTH0C04510g 255712279 8291287 392581..393042 1 NC_013079.1 highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A; KLTH0C04510p 393042 8291287 KLTH0C04510g Lachancea thermotolerans CBS 6340 KLTH0C04510p XP_002552422.1 392581 D 559295 CDS KLTH0C04532g 255712281 8291288 complement(393219..394286) 1 NC_013079.1 conserved hypothetical protein; KLTH0C04532p 394286 8291288 KLTH0C04532g Lachancea thermotolerans CBS 6340 KLTH0C04532p XP_002552423.1 393219 R 559295 CDS KLTH0C04554g 255712283 8291289 394461..398741 1 NC_013079.1 similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Hypothetical ORF; KLTH0C04554p 398741 8291289 KLTH0C04554g Lachancea thermotolerans CBS 6340 KLTH0C04554p XP_002552424.1 394461 D 559295 CDS KLTH0C04620g 255712285 8291292 400445..402091 1 NC_013079.1 similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C Hypothetical ORF; KLTH0C04620p 402091 8291292 KLTH0C04620g Lachancea thermotolerans CBS 6340 KLTH0C04620p XP_002552425.1 400445 D 559295 CDS KLTH0C04642g 255712287 8291293 402533..404860 1 NC_013079.1 weakly similar to uniprot|P08468 Saccharomyces cerevisiae YMR257C PET111 Specific translational activator for the COX2 mRNA located in the mitochondrial inner membrane; KLTH0C04642p 404860 8291293 KLTH0C04642g Lachancea thermotolerans CBS 6340 KLTH0C04642p XP_002552426.1 402533 D 559295 CDS KLTH0C04664g 255712289 8291294 405366..406286 1 NC_013079.1 some similarities with uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p- binding protein; KLTH0C04664p 406286 8291294 KLTH0C04664g Lachancea thermotolerans CBS 6340 KLTH0C04664p XP_002552427.1 405366 D 559295 CDS KLTH0C04686g 255712291 8291295 406899..407081 1 NC_013079.1 highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; KLTH0C04686p 407081 8291295 KLTH0C04686g Lachancea thermotolerans CBS 6340 KLTH0C04686p XP_002552428.1 406899 D 559295 CDS KLTH0C04708g 255712293 8291296 407666..408628 1 NC_013079.1 weakly similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W Hypothetical ORF; KLTH0C04708p 408628 8291296 KLTH0C04708g Lachancea thermotolerans CBS 6340 KLTH0C04708p XP_002552429.1 407666 D 559295 CDS KLTH0C04730g 255712295 8291297 complement(408668..409342) 1 NC_013079.1 some similarities with uniprot|Q04839 Saccharomyces cerevisiae YMR255W GFD1 Coiled-coiled protein of unknown function identified as a high-copy suppressor of a dbp5 mutation; KLTH0C04730p 409342 8291297 KLTH0C04730g Lachancea thermotolerans CBS 6340 KLTH0C04730p XP_002552430.1 408668 R 559295 CDS KLTH0C04752g 255712297 8291298 410449..411567 1 NC_013079.1 similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0C04752p 411567 8291298 KLTH0C04752g Lachancea thermotolerans CBS 6340 KLTH0C04752p XP_002552431.1 410449 D 559295 CDS KLTH0C04774g 255712299 8291299 411715..412092 1 NC_013079.1 similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF; KLTH0C04774p 412092 8291299 KLTH0C04774g Lachancea thermotolerans CBS 6340 KLTH0C04774p XP_002552432.1 411715 D 559295 CDS KLTH0C04796g 255712301 8291300 complement(412133..413842) 1 NC_013079.1 weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase; KLTH0C04796p 413842 8291300 KLTH0C04796g Lachancea thermotolerans CBS 6340 KLTH0C04796p XP_002552433.1 412133 R 559295 CDS KLTH0C04818g 255712303 8291301 416167..416994 1 NC_013079.1 highly similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation; KLTH0C04818p 416994 8291301 KLTH0C04818g Lachancea thermotolerans CBS 6340 KLTH0C04818p XP_002552434.1 416167 D 559295 CDS KLTH0C04840g 255712305 8291302 417074..417811 1 NC_013079.1 some similarities with uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization, possible component of the TOR nutrient signaling pathway; KLTH0C04840p 417811 8291302 KLTH0C04840g Lachancea thermotolerans CBS 6340 KLTH0C04840p XP_002552435.1 417074 D 559295 CDS KLTH0C04862g 255712307 8291303 418871..420571 1 NC_013079.1 weakly similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex required for Cdc7p kinase activity and initiation of DNA replication phosphorylates the Mcm2-7 family of proteins cell cycle regulated; KLTH0C04862p 420571 8291303 KLTH0C04862g Lachancea thermotolerans CBS 6340 KLTH0C04862p XP_002552436.1 418871 D 559295 CDS KLTH0C04884g 255712309 8291304 complement(422344..423372) 1 NC_013079.1 conserved hypothetical protein; KLTH0C04884p 423372 8291304 KLTH0C04884g Lachancea thermotolerans CBS 6340 KLTH0C04884p XP_002552437.1 422344 R 559295 CDS KLTH0C04906g 255712311 8291305 426008..429853 1 NC_013079.1 some similarities with uniprot|P53753 Saccharomyces cerevisiae YNR067C; KLTH0C04906p 429853 8291305 KLTH0C04906g Lachancea thermotolerans CBS 6340 KLTH0C04906p XP_002552438.1 426008 D 559295 CDS KLTH0C04928g 255712313 8291306 complement(429938..430450) 1 NC_013079.1 no similarity; KLTH0C04928p 430450 8291306 KLTH0C04928g Lachancea thermotolerans CBS 6340 KLTH0C04928p XP_002552439.1 429938 R 559295 CDS KLTH0C04950g 255712315 8291307 431617..433491 1 NC_013079.1 conserved hypothetical protein; KLTH0C04950p 433491 8291307 KLTH0C04950g Lachancea thermotolerans CBS 6340 KLTH0C04950p XP_002552440.1 431617 D 559295 CDS KLTH0C04972g 255712317 8291308 complement(433703..436591) 1 NC_013079.1 similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF; KLTH0C04972p 436591 8291308 KLTH0C04972g Lachancea thermotolerans CBS 6340 KLTH0C04972p XP_002552441.1 433703 R 559295 CDS KLTH0C04994g 255712319 8291309 437593..438699 1 NC_013079.1 highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents; KLTH0C04994p 438699 8291309 KLTH0C04994g Lachancea thermotolerans CBS 6340 KLTH0C04994p XP_002552442.1 437593 D 559295 CDS KLTH0C05016g 255712321 8291310 438918..440783 1 NC_013079.1 similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF; KLTH0C05016p 440783 8291310 KLTH0C05016g Lachancea thermotolerans CBS 6340 KLTH0C05016p XP_002552443.1 438918 D 559295 CDS KLTH0C05038g 255712323 8291311 complement(440815..443499) 1 NC_013079.1 similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference; KLTH0C05038p 443499 8291311 KLTH0C05038g Lachancea thermotolerans CBS 6340 KLTH0C05038p XP_002552444.1 440815 R 559295 CDS KLTH0C05060g 255712325 8291312 complement(443879..444421) 1 NC_013079.1 conserved hypothetical protein; KLTH0C05060p 444421 8291312 KLTH0C05060g Lachancea thermotolerans CBS 6340 KLTH0C05060p XP_002552445.1 443879 R 559295 CDS KLTH0C05082g 255712327 8291313 444707..445393 1 NC_013079.1 similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases; KLTH0C05082p 445393 8291313 KLTH0C05082g Lachancea thermotolerans CBS 6340 KLTH0C05082p XP_002552446.1 444707 D 559295 CDS KLTH0C05104g 255712329 8291314 complement(445672..446418) 1 NC_013079.1 highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase; KLTH0C05104p 446418 8291314 KLTH0C05104g Lachancea thermotolerans CBS 6340 KLTH0C05104p XP_002552447.1 445672 R 559295 CDS KLTH0C05126g 255712331 8291315 complement(446965..447897) 1 NC_013079.1 similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF; KLTH0C05126p 447897 8291315 KLTH0C05126g Lachancea thermotolerans CBS 6340 KLTH0C05126p XP_002552448.1 446965 R 559295 CDS KLTH0C05148g 255712333 8291316 448044..448568 1 NC_013079.1 conserved hypothetical protein; KLTH0C05148p 448568 8291316 KLTH0C05148g Lachancea thermotolerans CBS 6340 KLTH0C05148p XP_002552449.1 448044 D 559295 CDS KLTH0C05170g 255712335 8291317 449510..451306 1 NC_013079.1 similar to uniprot|P38084 Saccharomyces cerevisiae YBR068C BAP2 High-affinity leucine permease functions as a branched-chain amino acid permease involved in the uptake of leucine isoleucine and valine contains 12 predicted transmembrane domains and to YDR046C uniprot|P41815 Saccharomyces cerevisiae YDR046C BAP3 Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine; KLTH0C05170p 451306 8291317 KLTH0C05170g Lachancea thermotolerans CBS 6340 KLTH0C05170p XP_002552450.1 449510 D 559295 CDS KLTH0C05192g 255712337 8291318 451632..453407 1 NC_013079.1 highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis; KLTH0C05192p 453407 8291318 KLTH0C05192g Lachancea thermotolerans CBS 6340 KLTH0C05192p XP_002552451.1 451632 D 559295 CDS KLTH0C05214g 255712339 8291319 complement(453821..454732) 1 NC_013079.1 highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop; KLTH0C05214p 454732 8291319 KLTH0C05214g Lachancea thermotolerans CBS 6340 KLTH0C05214p XP_002552452.1 453821 R 559295 CDS KLTH0C05236g 255712341 8291320 455011..455622 1 NC_013079.1 similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins; KLTH0C05236p 455622 8291320 KLTH0C05236g Lachancea thermotolerans CBS 6340 KLTH0C05236p XP_002552453.1 455011 D 559295 CDS KLTH0C05258g 255712343 8291321 complement(join(455688..456130,456190..456205)) 1 NC_013079.1 similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF; KLTH0C05258p 456205 8291321 KLTH0C05258g Lachancea thermotolerans CBS 6340 KLTH0C05258p XP_002552454.1 455688 R 559295 CDS KLTH0C05280g 255712345 8291322 complement(456545..457561) 1 NC_013079.1 similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p; KLTH0C05280p 457561 8291322 KLTH0C05280g Lachancea thermotolerans CBS 6340 KLTH0C05280p XP_002552455.1 456545 R 559295 CDS KLTH0C05324g 255712347 8291625 complement(458911..460110) 1 NC_013079.1 similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex; KLTH0C05324p 460110 8291625 KLTH0C05324g Lachancea thermotolerans CBS 6340 KLTH0C05324p XP_002552456.1 458911 R 559295 CDS KLTH0C05346g 255712349 8291324 460241..460549 1 NC_013079.1 similar to uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex; KLTH0C05346p 460549 8291324 KLTH0C05346g Lachancea thermotolerans CBS 6340 KLTH0C05346p XP_002552457.1 460241 D 559295 CDS KLTH0C05368g 255712351 8291325 461904..463112 1 NC_013079.1 weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria; KLTH0C05368p 463112 8291325 KLTH0C05368g Lachancea thermotolerans CBS 6340 KLTH0C05368p XP_002552458.1 461904 D 559295 CDS KLTH0C05390g 255712353 8291326 463262..464902 1 NC_013079.1 highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino- terminal sequence; KLTH0C05390p 464902 8291326 KLTH0C05390g Lachancea thermotolerans CBS 6340 KLTH0C05390p XP_002552459.1 463262 D 559295 CDS KLTH0C05412g 255712355 8291327 complement(465827..467314) 1 NC_013079.1 similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Tryptophan 2 3-dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; KLTH0C05412p 467314 8291327 KLTH0C05412g Lachancea thermotolerans CBS 6340 KLTH0C05412p XP_002552460.1 465827 R 559295 CDS KLTH0C05434g 255712357 8291328 complement(467681..468277) 1 NC_013079.1 similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF; KLTH0C05434p 468277 8291328 KLTH0C05434g Lachancea thermotolerans CBS 6340 KLTH0C05434p XP_002552461.1 467681 R 559295 CDS KLTH0C05456g 255712359 8291329 complement(468453..471500) 1 NC_013079.1 similar to uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YPR032W uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae; KLTH0C05456p 471500 8291329 KLTH0C05456g Lachancea thermotolerans CBS 6340 KLTH0C05456p XP_002552462.1 468453 R 559295 CDS KLTH0C05478g 255712361 8291330 complement(471760..475254) 1 NC_013079.1 similar to uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein Kinase C; KLTH0C05478p 475254 8291330 KLTH0C05478g Lachancea thermotolerans CBS 6340 KLTH0C05478p XP_002552463.1 471760 R 559295 CDS KLTH0C05500g 255712363 8291331 complement(475687..478644) 1 NC_013079.1 similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF; KLTH0C05500p 478644 8291331 KLTH0C05500g Lachancea thermotolerans CBS 6340 KLTH0C05500p XP_002552464.1 475687 R 559295 CDS KLTH0C05522g 255712365 8291332 complement(478791..480956) 1 NC_013079.1 similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex; KLTH0C05522p 480956 8291332 KLTH0C05522g Lachancea thermotolerans CBS 6340 KLTH0C05522p XP_002552465.1 478791 R 559295 CDS KLTH0C05544g 255712367 8291333 complement(481394..482584) 1 NC_013079.1 some similarities with uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop- helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein Rtg1p to activate the retrograde (RTG) and TOR pathways; KLTH0C05544p 482584 8291333 KLTH0C05544g Lachancea thermotolerans CBS 6340 KLTH0C05544p XP_002552466.1 481394 R 559295 CDS KLTH0C05566g 255712369 8291334 482829..483464 1 NC_013079.1 similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W; KLTH0C05566p 483464 8291334 KLTH0C05566g Lachancea thermotolerans CBS 6340 KLTH0C05566p XP_002552467.1 482829 D 559295 CDS KLTH0C05588g 255712371 8291335 complement(483483..486344) 1 NC_013079.1 weakly similar to uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements; KLTH0C05588p 486344 8291335 KLTH0C05588g Lachancea thermotolerans CBS 6340 KLTH0C05588p XP_002552468.1 483483 R 559295 CDS KLTH0C05610g 255712373 8291336 486702..489095 1 NC_013079.1 similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin- associated protein (AP) complex; KLTH0C05610p 489095 8291336 KLTH0C05610g Lachancea thermotolerans CBS 6340 KLTH0C05610p XP_002552469.1 486702 D 559295 CDS KLTH0C05632g 255712375 8291337 complement(join(489189..489689,489815..489865)) 1 NC_013079.1 similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion; KLTH0C05632p 489865 8291337 KLTH0C05632g Lachancea thermotolerans CBS 6340 KLTH0C05632p XP_002552470.1 489189 R 559295 CDS KLTH0C05676g 255712377 8291339 complement(490279..493737) 1 NC_013079.1 similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization; KLTH0C05676p 493737 8291339 KLTH0C05676g Lachancea thermotolerans CBS 6340 KLTH0C05676p XP_002552471.1 490279 R 559295 CDS KLTH0C05698g 255712379 8291340 495922..497568 1 NC_013079.1 highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0C05698p 497568 8291340 KLTH0C05698g Lachancea thermotolerans CBS 6340 KLTH0C05698p XP_002552472.1 495922 D 559295 CDS KLTH0C05720g 255712381 8291341 498103..499230 1 NC_013079.1 similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy- terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; KLTH0C05720p 499230 8291341 KLTH0C05720g Lachancea thermotolerans CBS 6340 KLTH0C05720p XP_002552473.1 498103 D 559295 CDS KLTH0C05742g 255712383 8291342 complement(499428..501662) 1 NC_013079.1 highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover; KLTH0C05742p 501662 8291342 KLTH0C05742g Lachancea thermotolerans CBS 6340 KLTH0C05742p XP_002552474.1 499428 R 559295 CDS KLTH0C05764g 255712385 8291343 complement(502173..504551) 1 NC_013079.1 similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics; KLTH0C05764p 504551 8291343 KLTH0C05764g Lachancea thermotolerans CBS 6340 KLTH0C05764p XP_002552475.1 502173 R 559295 CDS KLTH0C05786g 255712387 8291344 complement(504634..506025) 1 NC_013079.1 similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; KLTH0C05786p 506025 8291344 KLTH0C05786g Lachancea thermotolerans CBS 6340 KLTH0C05786p XP_002552476.1 504634 R 559295 CDS KLTH0C05808g 255712389 8291345 complement(506792..508741) 1 NC_013079.1 weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p; KLTH0C05808p 508741 8291345 KLTH0C05808g Lachancea thermotolerans CBS 6340 KLTH0C05808p XP_002552477.1 506792 R 559295 CDS KLTH0C05830g 255712391 8291346 510023..510763 1 NC_013079.1 similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF; KLTH0C05830p 510763 8291346 KLTH0C05830g Lachancea thermotolerans CBS 6340 KLTH0C05830p XP_002552478.1 510023 D 559295 CDS KLTH0C05852g 255712393 8291347 510994..512418 1 NC_013079.1 similar to uniprot|P38682 Saccharomyces cerevisiae YER122C; KLTH0C05852p 512418 8291347 KLTH0C05852g Lachancea thermotolerans CBS 6340 KLTH0C05852p XP_002552479.1 510994 D 559295 CDS KLTH0C05874g 255712395 8291348 complement(512656..513267) 1 NC_013079.1 similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component; KLTH0C05874p 513267 8291348 KLTH0C05874g Lachancea thermotolerans CBS 6340 KLTH0C05874p XP_002552480.1 512656 R 559295 CDS KLTH0C05896g 255712397 8291349 complement(513373..514191) 1 NC_013079.1 no similarity; KLTH0C05896p 514191 8291349 KLTH0C05896g Lachancea thermotolerans CBS 6340 KLTH0C05896p XP_002552481.1 513373 R 559295 CDS KLTH0C05918g 255712399 8291350 514317..514712 1 NC_013079.1 highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein; KLTH0C05918p 514712 8291350 KLTH0C05918g Lachancea thermotolerans CBS 6340 KLTH0C05918p XP_002552482.1 514317 D 559295 CDS KLTH0C05940g 255712401 8291351 complement(join(514929..515626,515905..515941)) 1 NC_013079.1 similar to uniprot|P40075 Saccharomyces cerevisiae YER120W SCS2 Protein likely to be involved in regulating INO1 expression suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline involved in inositol metabolism regulator of INO1 expression; KLTH0C05940p 515941 8291351 KLTH0C05940g Lachancea thermotolerans CBS 6340 KLTH0C05940p XP_002552483.1 514929 R 559295 CDS KLTH0C05962g 255712403 8291352 complement(516175..517437) 1 NC_013079.1 highly similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p; KLTH0C05962p 517437 8291352 KLTH0C05962g Lachancea thermotolerans CBS 6340 KLTH0C05962p XP_002552484.1 516175 R 559295 CDS KLTH0C05984g 255712405 8291353 517472..518128 1 NC_013079.1 weakly similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences; KLTH0C05984p 518128 8291353 KLTH0C05984g Lachancea thermotolerans CBS 6340 KLTH0C05984p XP_002552485.1 517472 D 559295 CDS KLTH0C06006g 255712407 8291354 518793..520130 1 NC_013079.1 similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; KLTH0C06006p 520130 8291354 KLTH0C06006g Lachancea thermotolerans CBS 6340 KLTH0C06006p XP_002552486.1 518793 D 559295 CDS KLTH0C06028g 255712409 8291355 520445..521473 1 NC_013079.1 similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high- osmolarity glycerol response pathway; KLTH0C06028p 521473 8291355 KLTH0C06028g Lachancea thermotolerans CBS 6340 KLTH0C06028p XP_002552487.1 520445 D 559295 CDS KLTH0C06050g 255712411 8291356 complement(521583..530027) 1 NC_013079.1 similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene; KLTH0C06050p 530027 8291356 KLTH0C06050g Lachancea thermotolerans CBS 6340 KLTH0C06050p XP_002552488.1 521583 R 559295 CDS KLTH0C06072g 255712413 8291357 complement(join(530038..530409,530639..530680)) 1 NC_013079.1 highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W RPL23B and highly similar to uniprot|P04451 Saccharomyces cerevisiae YBL087C RPL23A Proteins component of the large (60S) ribosomal subunit; KLTH0C06072p 530680 8291357 KLTH0C06072g Lachancea thermotolerans CBS 6340 KLTH0C06072p XP_002552489.1 530038 R 559295 CDS KLTH0C06094g 255712415 8291358 531296..531883 1 NC_013079.1 some similarities with uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair; KLTH0C06094p 531883 8291358 KLTH0C06094g Lachancea thermotolerans CBS 6340 KLTH0C06094p XP_002552490.1 531296 D 559295 CDS KLTH0C06116g 255712417 8291359 532040..532357 1 NC_013079.1 conserved hypothetical protein; KLTH0C06116p 532357 8291359 KLTH0C06116g Lachancea thermotolerans CBS 6340 KLTH0C06116p XP_002552491.1 532040 D 559295 CDS KLTH0C06138g 255712419 8291360 complement(532436..533704) 1 NC_013079.1 similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0C06138p 533704 8291360 KLTH0C06138g Lachancea thermotolerans CBS 6340 KLTH0C06138p XP_002552492.1 532436 R 559295 CDS KLTH0C06160g 255712421 8291361 533876..534991 1 NC_013079.1 conserved hypothetical protein; KLTH0C06160p 534991 8291361 KLTH0C06160g Lachancea thermotolerans CBS 6340 KLTH0C06160p XP_002552493.1 533876 D 559295 CDS KLTH0C06182g 255712423 8291362 535274..538351 1 NC_013079.1 similar to uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud- emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; KLTH0C06182p 538351 8291362 KLTH0C06182g Lachancea thermotolerans CBS 6340 KLTH0C06182p XP_002552494.1 535274 D 559295 CDS KLTH0C06204g 255712425 8291363 complement(538533..540416) 1 NC_013079.1 some similarities with uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0C06204p 540416 8291363 KLTH0C06204g Lachancea thermotolerans CBS 6340 KLTH0C06204p XP_002552495.1 538533 R 559295 CDS KLTH0C06226g 255712427 8291364 541022..543106 1 NC_013079.1 similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF; KLTH0C06226p 543106 8291364 KLTH0C06226g Lachancea thermotolerans CBS 6340 KLTH0C06226p XP_002552496.1 541022 D 559295 CDS KLTH0C06248g 255712429 8291365 complement(543231..543758) 1 NC_013079.1 weakly similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay; KLTH0C06248p 543758 8291365 KLTH0C06248g Lachancea thermotolerans CBS 6340 KLTH0C06248p XP_002552497.1 543231 R 559295 CDS KLTH0C06270g 255712431 8291366 544802..547510 1 NC_013079.1 some similarities with uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor; KLTH0C06270p 547510 8291366 KLTH0C06270g Lachancea thermotolerans CBS 6340 KLTH0C06270p XP_002552498.1 544802 D 559295 CDS KLTH0C06292g 255712433 8291367 547894..551229 1 NC_013079.1 highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1; KLTH0C06292p 551229 8291367 KLTH0C06292g Lachancea thermotolerans CBS 6340 KLTH0C06292p XP_002552499.1 547894 D 559295 CDS KLTH0C06314g 255712435 8291368 551494..552852 1 NC_013079.1 similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1- 3) mannosyltransferase involved in the synthesis of dolichol- linked oligosaccharide donor for N-linked glycosylation of proteins; KLTH0C06314p 552852 8291368 KLTH0C06314g Lachancea thermotolerans CBS 6340 KLTH0C06314p XP_002552500.1 551494 D 559295 CDS KLTH0C06336g 255712437 8291369 553260..556295 1 NC_013079.1 weakly similar to uniprot|P40068 Saccharomyces cerevisiae YER109C FLO8 Transcription; KLTH0C06336p 556295 8291369 KLTH0C06336g Lachancea thermotolerans CBS 6340 KLTH0C06336p XP_002552501.1 553260 D 559295 CDS KLTH0C06358g 255712439 8291370 556638..557741 1 NC_013079.1 highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p; KLTH0C06358p 557741 8291370 KLTH0C06358g Lachancea thermotolerans CBS 6340 KLTH0C06358p XP_002552502.1 556638 D 559295 CDS KLTH0C06380g 255712441 8291371 558176..559189 1 NC_013079.1 some similarities with uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF; KLTH0C06380p 559189 8291371 KLTH0C06380g Lachancea thermotolerans CBS 6340 KLTH0C06380p XP_002552503.1 558176 D 559295 CDS KLTH0C06402g 255712443 8291372 complement(559759..561402) 1 NC_013079.1 similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation; KLTH0C06402p 561402 8291372 KLTH0C06402g Lachancea thermotolerans CBS 6340 KLTH0C06402p XP_002552504.1 559759 R 559295 CDS KLTH0C06424g 255712445 8291373 complement(561526..561816) 1 NC_013079.1 no similarity; KLTH0C06424p 561816 8291373 KLTH0C06424g Lachancea thermotolerans CBS 6340 KLTH0C06424p XP_002552505.1 561526 R 559295 CDS KLTH0C06446g 255712447 8291374 complement(561870..562811) 1 NC_013079.1 conserved hypothetical protein; KLTH0C06446p 562811 8291374 KLTH0C06446g Lachancea thermotolerans CBS 6340 KLTH0C06446p XP_002552506.1 561870 R 559295 CDS KLTH0C06468g 255712449 8291375 563097..567413 1 NC_013079.1 similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation; KLTH0C06468p 567413 8291375 KLTH0C06468g Lachancea thermotolerans CBS 6340 KLTH0C06468p XP_002552507.1 563097 D 559295 CDS KLTH0C06490g 255712451 8291376 complement(568138..568494) 1 NC_013079.1 highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy; KLTH0C06490p 568494 8291376 KLTH0C06490g Lachancea thermotolerans CBS 6340 KLTH0C06490p XP_002552508.1 568138 R 559295 CDS KLTH0C06512g 255712453 8291377 complement(568842..569399) 1 NC_013079.1 weakly similar to uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 Protein with a role in regulation of Ty1 transposition; KLTH0C06512p 569399 8291377 KLTH0C06512g Lachancea thermotolerans CBS 6340 KLTH0C06512p XP_002552509.1 568842 R 559295 CDS KLTH0C06534g 255712455 8291378 complement(569680..572898) 1 NC_013079.1 highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A; KLTH0C06534p 572898 8291378 KLTH0C06534g Lachancea thermotolerans CBS 6340 KLTH0C06534p XP_002552510.1 569680 R 559295 CDS KLTH0C06556g 255712457 8291379 complement(573847..575820) 1 NC_013079.1 highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family; KLTH0C06556p 575820 8291379 KLTH0C06556g Lachancea thermotolerans CBS 6340 KLTH0C06556p XP_002552511.1 573847 R 559295 CDS KLTH0C06578g 255712459 8291380 complement(576374..577453) 1 NC_013079.1 similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre- mRNA of the MATa1 cistron; KLTH0C06578p 577453 8291380 KLTH0C06578g Lachancea thermotolerans CBS 6340 KLTH0C06578p XP_002552512.1 576374 R 559295 CDS KLTH0C06622g 255712461 8291626 complement(578157..578762) 1 NC_013079.1 similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit; KLTH0C06622p 578762 8291626 KLTH0C06622g Lachancea thermotolerans CBS 6340 KLTH0C06622p XP_002552513.1 578157 R 559295 CDS KLTH0C06644g 255712463 8291382 579529..579882 1 NC_013079.1 highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p; KLTH0C06644p 579882 8291382 KLTH0C06644g Lachancea thermotolerans CBS 6340 KLTH0C06644p XP_002552514.1 579529 D 559295 CDS KLTH0C06666g 255712465 8291383 580203..581489 1 NC_013079.1 weakly similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein; KLTH0C06666p 581489 8291383 KLTH0C06666g Lachancea thermotolerans CBS 6340 KLTH0C06666p XP_002552515.1 580203 D 559295 CDS KLTH0C06688g 255712467 8291384 complement(581697..582437) 1 NC_013079.1 similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER- associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway; KLTH0C06688p 582437 8291384 KLTH0C06688g Lachancea thermotolerans CBS 6340 KLTH0C06688p XP_002552516.1 581697 R 559295 CDS KLTH0C06710g 255712469 8291385 582940..583953 1 NC_013079.1 highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; KLTH0C06710p 583953 8291385 KLTH0C06710g Lachancea thermotolerans CBS 6340 KLTH0C06710p XP_002552517.1 582940 D 559295 CDS KLTH0C06732g 255712471 8291386 complement(584097..586241) 1 NC_013079.1 some similarities with uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; KLTH0C06732p 586241 8291386 KLTH0C06732g Lachancea thermotolerans CBS 6340 KLTH0C06732p XP_002552518.1 584097 R 559295 CDS KLTH0C06776g 255712473 8291388 complement(586976..590140) 1 NC_013079.1 similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Suppressor of Essential Function putative transcription factor; KLTH0C06776p 590140 8291388 KLTH0C06776g Lachancea thermotolerans CBS 6340 KLTH0C06776p XP_002552519.1 586976 R 559295 CDS KLTH0C06798g 255712475 8291389 complement(590991..591740) 1 NC_013079.1 similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress; KLTH0C06798p 591740 8291389 KLTH0C06798g Lachancea thermotolerans CBS 6340 KLTH0C06798p XP_002552520.1 590991 R 559295 CDS KLTH0C06820g 255712477 8291390 complement(592854..594800) 1 NC_013079.1 similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation; KLTH0C06820p 594800 8291390 KLTH0C06820g Lachancea thermotolerans CBS 6340 KLTH0C06820p XP_002552521.1 592854 R 559295 CDS KLTH0C06842g 255712479 8291391 complement(595165..596310) 1 NC_013079.1 similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein forms a helical filament with DNA that searches for homology involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis homolog of Dmc1p and bacterial RecA protein; KLTH0C06842p 596310 8291391 KLTH0C06842g Lachancea thermotolerans CBS 6340 KLTH0C06842p XP_002552522.1 595165 R 559295 CDS KLTH0C06864g 255712481 8291392 596687..598597 1 NC_013079.1 weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF; KLTH0C06864p 598597 8291392 KLTH0C06864g Lachancea thermotolerans CBS 6340 KLTH0C06864p XP_002552523.1 596687 D 559295 CDS KLTH0C06886g 255712483 8291393 join(598854..598878,599007..599599) 1 NC_013079.1 highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10; KLTH0C06886p 599599 8291393 KLTH0C06886g Lachancea thermotolerans CBS 6340 KLTH0C06886p XP_002552524.1 598854 D 559295 CDS KLTH0C06908g 255712485 8291394 complement(join(599791..600080,600141..600174)) 1 NC_013079.1 highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca; KLTH0C06908p 600174 8291394 KLTH0C06908g Lachancea thermotolerans CBS 6340 KLTH0C06908p XP_002552525.1 599791 R 559295 CDS KLTH0C06930g 255712487 8291395 join(600316..600469,600533..600831) 1 NC_013079.1 similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF; KLTH0C06930p 600831 8291395 KLTH0C06930g Lachancea thermotolerans CBS 6340 KLTH0C06930p XP_002552526.1 600316 D 559295 CDS KLTH0C06952g 255712489 8291396 601001..604990 1 NC_013079.1 similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability; KLTH0C06952p 604990 8291396 KLTH0C06952g Lachancea thermotolerans CBS 6340 KLTH0C06952p XP_002552527.1 601001 D 559295 CDS KLTH0C06974g 255712491 8291397 complement(605132..605476) 1 NC_013079.1 similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; KLTH0C06974p 605476 8291397 KLTH0C06974g Lachancea thermotolerans CBS 6340 KLTH0C06974p XP_002552528.1 605132 R 559295 CDS KLTH0C06996g 255712493 8291398 complement(606308..606895) 1 NC_013079.1 no similarity; KLTH0C06996p 606895 8291398 KLTH0C06996g Lachancea thermotolerans CBS 6340 KLTH0C06996p XP_002552529.1 606308 R 559295 CDS KLTH0C07018g 255712495 8291399 608415..610721 1 NC_013079.1 highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase; KLTH0C07018p 610721 8291399 KLTH0C07018g Lachancea thermotolerans CBS 6340 KLTH0C07018p XP_002552530.1 608415 D 559295 CDS KLTH0C07040g 255712497 8291400 join(611631..611723,611832..612896) 1 NC_013079.1 similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain- containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; KLTH0C07040p 612896 8291400 KLTH0C07040g Lachancea thermotolerans CBS 6340 KLTH0C07040p XP_002552531.1 611631 D 559295 CDS KLTH0C07062g 255712499 8291401 complement(612938..613573) 1 NC_013079.1 similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase; KLTH0C07062p 613573 8291401 KLTH0C07062g Lachancea thermotolerans CBS 6340 KLTH0C07062p XP_002552532.1 612938 R 559295 CDS KLTH0C07084g 255712501 8291402 complement(613733..615253) 1 NC_013079.1 similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I; KLTH0C07084p 615253 8291402 KLTH0C07084g Lachancea thermotolerans CBS 6340 KLTH0C07084p XP_002552533.1 613733 R 559295 CDS KLTH0C07106g 255712503 8291403 complement(615350..615718) 1 NC_013079.1 no similarity; KLTH0C07106p 615718 8291403 KLTH0C07106g Lachancea thermotolerans CBS 6340 KLTH0C07106p XP_002552534.1 615350 R 559295 CDS KLTH0C07128g 255712505 8291404 616999..618348 1 NC_013079.1 similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation; KLTH0C07128p 618348 8291404 KLTH0C07128g Lachancea thermotolerans CBS 6340 KLTH0C07128p XP_002552535.1 616999 D 559295 CDS KLTH0C07150g 255712507 8291405 complement(618784..620010) 1 NC_013079.1 similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF; KLTH0C07150p 620010 8291405 KLTH0C07150g Lachancea thermotolerans CBS 6340 KLTH0C07150p XP_002552536.1 618784 R 559295 CDS KLTH0C07172g 255712509 8291406 complement(620315..621112) 1 NC_013079.1 some similarities with uniprot|Q03125 Saccharomyces cerevisiae YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; KLTH0C07172p 621112 8291406 KLTH0C07172g Lachancea thermotolerans CBS 6340 KLTH0C07172p XP_002552537.1 620315 R 559295 CDS KLTH0C07194g 255712511 8291407 622607..623590 1 NC_013079.1 highly similar to uniprot|P11353 YDR044W Saccharomyces cerevisiae HEM13 Coproporphyrinogen III oxidase; KLTH0C07194p 623590 8291407 KLTH0C07194g Lachancea thermotolerans CBS 6340 KLTH0C07194p XP_002552538.1 622607 D 559295 CDS KLTH0C07216g 255712513 8291408 complement(623707..624090) 1 NC_013079.1 highly similar to uniprot|Q04307 Saccharomyces cerevisiae YDR045C RPC11 RNA polymerase III subunit C11; KLTH0C07216p 624090 8291408 KLTH0C07216g Lachancea thermotolerans CBS 6340 KLTH0C07216p XP_002552539.1 623707 R 559295 CDS KLTH0C07238g 255712515 8291409 624255..626153 1 NC_013079.1 some similarities with uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex; KLTH0C07238p 626153 8291409 KLTH0C07238g Lachancea thermotolerans CBS 6340 KLTH0C07238p XP_002552540.1 624255 D 559295 CDS KLTH0C07260g 255712517 8291410 626334..629039 1 NC_013079.1 similar to uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Ser-Thr protein kinase; KLTH0C07260p 629039 8291410 KLTH0C07260g Lachancea thermotolerans CBS 6340 KLTH0C07260p XP_002552541.1 626334 D 559295 CDS KLTH0C07282g 255712519 8291411 complement(629716..630861) 1 NC_013079.1 conserved hypothetical protein; KLTH0C07282p 630861 8291411 KLTH0C07282g Lachancea thermotolerans CBS 6340 KLTH0C07282p XP_002552542.1 629716 R 559295 CDS KLTH0C07304g 255712521 8291412 632098..633528 1 NC_013079.1 weakly similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases; KLTH0C07304p 633528 8291412 KLTH0C07304g Lachancea thermotolerans CBS 6340 KLTH0C07304p XP_002552543.1 632098 D 559295 CDS KLTH0C07326g 255712523 8291413 633748..636036 1 NC_013079.1 weakly similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; KLTH0C07326p 636036 8291413 KLTH0C07326g Lachancea thermotolerans CBS 6340 KLTH0C07326p XP_002552544.1 633748 D 559295 CDS KLTH0C07348g 255712525 8291414 636295..637245 1 NC_013079.1 weakly similar to uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation; KLTH0C07348p 637245 8291414 KLTH0C07348g Lachancea thermotolerans CBS 6340 KLTH0C07348p XP_002552545.1 636295 D 559295 CDS KLTH0C07370g 255712527 8291415 complement(637434..638666) 1 NC_013079.1 weakly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino- heptulosonate-7- phosphate (DAHP) synthase; KLTH0C07370p 638666 8291415 KLTH0C07370g Lachancea thermotolerans CBS 6340 KLTH0C07370p XP_002552546.1 637434 R 559295 CDS KLTH0C07414g 255712529 8291417 complement(639510..640991) 1 NC_013079.1 weakly similar to uniprot|P38081 YBR056w Saccharomyces cerevisiae Hypothetical ORF; KLTH0C07414p 640991 8291417 KLTH0C07414g Lachancea thermotolerans CBS 6340 KLTH0C07414p XP_002552547.1 639510 R 559295 CDS KLTH0C07458g 255712531 8291419 642381..645116 1 NC_013079.1 similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex; KLTH0C07458p 645116 8291419 KLTH0C07458g Lachancea thermotolerans CBS 6340 KLTH0C07458p XP_002552548.1 642381 D 559295 CDS KLTH0C07480g 255712533 8291420 645219..647546 1 NC_013079.1 similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co- inducer; KLTH0C07480p 647546 8291420 KLTH0C07480g Lachancea thermotolerans CBS 6340 KLTH0C07480p XP_002552549.1 645219 D 559295 CDS KLTH0C07502g 255712535 8291421 complement(647606..648883) 1 NC_013079.1 conserved hypothetical protein; KLTH0C07502p 648883 8291421 KLTH0C07502g Lachancea thermotolerans CBS 6340 KLTH0C07502p XP_002552550.1 647606 R 559295 CDS KLTH0C07524g 255712537 8291422 649209..650657 1 NC_013079.1 similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF; KLTH0C07524p 650657 8291422 KLTH0C07524g Lachancea thermotolerans CBS 6340 KLTH0C07524p XP_002552551.1 649209 D 559295 CDS KLTH0C07546g 255712539 8291423 651330..652469 1 NC_013079.1 similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C; KLTH0C07546p 652469 8291423 KLTH0C07546g Lachancea thermotolerans CBS 6340 KLTH0C07546p XP_002552552.1 651330 D 559295 CDS KLTH0C07590g 255712541 8291425 652890..653507 1 NC_013079.1 similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0C07590p 653507 8291425 KLTH0C07590g Lachancea thermotolerans CBS 6340 KLTH0C07590p XP_002552553.1 652890 D 559295 CDS KLTH0C07612g 255712543 8291426 complement(653652..653987) 1 NC_013079.1 highly similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W Hypothetical; KLTH0C07612p 653987 8291426 KLTH0C07612g Lachancea thermotolerans CBS 6340 KLTH0C07612p XP_002552554.1 653652 R 559295 CDS KLTH0C07634g 255712545 8291427 654087..655364 1 NC_013079.1 weakly similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in transcription- coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSA protein; KLTH0C07634p 655364 8291427 KLTH0C07634g Lachancea thermotolerans CBS 6340 KLTH0C07634p XP_002552555.1 654087 D 559295 CDS KLTH0C07656g 255712547 8291428 656693..659254 1 NC_013079.1 similar to uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing; KLTH0C07656p 659254 8291428 KLTH0C07656g Lachancea thermotolerans CBS 6340 KLTH0C07656p XP_002552556.1 656693 D 559295 CDS KLTH0C07678g 255712549 8291429 659489..662236 1 NC_013079.1 similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex; KLTH0C07678p 662236 8291429 KLTH0C07678g Lachancea thermotolerans CBS 6340 KLTH0C07678p XP_002552557.1 659489 D 559295 CDS KLTH0C07700g 255712551 8291430 663191..663970 1 NC_013079.1 conserved hypothetical protein; KLTH0C07700p 663970 8291430 KLTH0C07700g Lachancea thermotolerans CBS 6340 KLTH0C07700p XP_002552558.1 663191 D 559295 CDS KLTH0C07722g 255712553 8291431 664219..665022 1 NC_013079.1 conserved hypothetical protein; KLTH0C07722p 665022 8291431 KLTH0C07722g Lachancea thermotolerans CBS 6340 KLTH0C07722p XP_002552559.1 664219 D 559295 CDS KLTH0C07744g 255712555 8291432 665986..666552 1 NC_013079.1 conserved hypothetical protein; KLTH0C07744p 666552 8291432 KLTH0C07744g Lachancea thermotolerans CBS 6340 KLTH0C07744p XP_002552560.1 665986 D 559295 CDS KLTH0C07766g 255712557 8291433 667271..667798 1 NC_013079.1 no similarity; KLTH0C07766p 667798 8291433 KLTH0C07766g Lachancea thermotolerans CBS 6340 KLTH0C07766p XP_002552561.1 667271 D 559295 CDS KLTH0C07788g 255712559 8291434 668801..670873 1 NC_013079.1 some similarities with uniprot|Q12457 Saccharomyces cerevisiae YDR026C Hypothetical ORF; KLTH0C07788p 670873 8291434 KLTH0C07788g Lachancea thermotolerans CBS 6340 KLTH0C07788p XP_002552562.1 668801 D 559295 CDS KLTH0C07810g 255712561 8291435 complement(join(671112..671537,671839..671883)) 1 NC_013079.1 highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025w RPS18A or uniprot|P26781 Saccharomyces cerevisiae YBR048w RPS18B ribosomal protein; KLTH0C07810p 671883 8291435 KLTH0C07810g Lachancea thermotolerans CBS 6340 KLTH0C07810p XP_002552563.1 671112 R 559295 CDS KLTH0C07832g 255712563 8291436 complement(672626..673165) 1 NC_013079.1 similar to uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23; KLTH0C07832p 673165 8291436 KLTH0C07832g Lachancea thermotolerans CBS 6340 KLTH0C07832p XP_002552564.1 672626 R 559295 CDS KLTH0C07854g 255712565 8291437 673945..675021 1 NC_013079.1 similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C ZTA1 Zeta-crystallin homolog; KLTH0C07854p 675021 8291437 KLTH0C07854g Lachancea thermotolerans CBS 6340 KLTH0C07854p XP_002552565.1 673945 D 559295 CDS KLTH0C07876g 255712567 8291438 675193..676974 1 NC_013079.1 similar to uniprot|P32833 Saccharomyces cerevisiae YBR060C ORC2 Subunit of the origin recognition complex; KLTH0C07876p 676974 8291438 KLTH0C07876g Lachancea thermotolerans CBS 6340 KLTH0C07876p XP_002552566.1 675193 D 559295 CDS KLTH0C07898g 255712569 8291439 complement(677089..678474) 1 NC_013079.1 highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase; KLTH0C07898p 678474 8291439 KLTH0C07898g Lachancea thermotolerans CBS 6340 KLTH0C07898p XP_002552567.1 677089 R 559295 CDS KLTH0C07942g 255712571 8291441 679383..679820 1 NC_013079.1 weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Protein involved in microtubule assembly; KLTH0C07942p 679820 8291441 KLTH0C07942g Lachancea thermotolerans CBS 6340 KLTH0C07942p XP_002552568.1 679383 D 559295 CDS KLTH0C07964g 255712573 8291442 complement(679877..681073) 1 NC_013079.1 highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; KLTH0C07964p 681073 8291442 KLTH0C07964g Lachancea thermotolerans CBS 6340 KLTH0C07964p XP_002552569.1 679877 R 559295 CDS KLTH0C07986g 255712575 8291443 681249..681878 1 NC_013079.1 similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C Hypothetical ORF; KLTH0C07986p 681878 8291443 KLTH0C07986g Lachancea thermotolerans CBS 6340 KLTH0C07986p XP_002552570.1 681249 D 559295 CDS KLTH0C08008g 255712577 8291444 682247..683920 1 NC_013079.1 similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone; KLTH0C08008p 683920 8291444 KLTH0C08008g Lachancea thermotolerans CBS 6340 KLTH0C08008p XP_002552571.1 682247 D 559295 CDS KLTH0C08030g 255712579 8291445 684324..685493 1 NC_013079.1 similar to uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1); KLTH0C08030p 685493 8291445 KLTH0C08030g Lachancea thermotolerans CBS 6340 KLTH0C08030p XP_002552572.1 684324 D 559295 CDS KLTH0C08052g 255712581 8291446 685805..687604 1 NC_013079.1 similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p; KLTH0C08052p 687604 8291446 KLTH0C08052g Lachancea thermotolerans CBS 6340 KLTH0C08052p XP_002552573.1 685805 D 559295 CDS KLTH0C08074g 255712583 8291447 688367..690295 1 NC_013079.1 similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS- MDR); KLTH0C08074p 690295 8291447 KLTH0C08074g Lachancea thermotolerans CBS 6340 KLTH0C08074p XP_002552574.1 688367 D 559295 CDS KLTH0C08096g 255712585 8291448 690559..691761 1 NC_013079.1 similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C Hypothetical ORF; KLTH0C08096p 691761 8291448 KLTH0C08096g Lachancea thermotolerans CBS 6340 KLTH0C08096p XP_002552575.1 690559 D 559295 CDS KLTH0C08118g 255712587 8291449 complement(691865..693877) 1 NC_013079.1 similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; KLTH0C08118p 693877 8291449 KLTH0C08118g Lachancea thermotolerans CBS 6340 KLTH0C08118p XP_002552576.1 691865 R 559295 CDS KLTH0C08140g 255712589 8291450 complement(694025..694903) 1 NC_013079.1 similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating; KLTH0C08140p 694903 8291450 KLTH0C08140g Lachancea thermotolerans CBS 6340 KLTH0C08140p XP_002552577.1 694025 R 559295 CDS KLTH0C08162g 255712591 8291451 complement(695385..696266) 1 NC_013079.1 similar to uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0C08162p 696266 8291451 KLTH0C08162g Lachancea thermotolerans CBS 6340 KLTH0C08162p XP_002552578.1 695385 R 559295 CDS KLTH0C08184g 255712593 8291452 697163..699823 1 NC_013079.1 similar to uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats; KLTH0C08184p 699823 8291452 KLTH0C08184g Lachancea thermotolerans CBS 6340 KLTH0C08184p XP_002552579.1 697163 D 559295 CDS KLTH0C08206g 255712595 8291453 700272..700565 1 NC_013079.1 similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; KLTH0C08206p 700565 8291453 KLTH0C08206g Lachancea thermotolerans CBS 6340 KLTH0C08206p XP_002552580.1 700272 D 559295 CDS KLTH0C08250g 255712597 8291455 complement(701335..702309) 1 NC_013079.1 some similarities with uniprot|Q03937 Saccharomyces cerevisiae YDR014W-A HED1 Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; KLTH0C08250p 702309 8291455 KLTH0C08250g Lachancea thermotolerans CBS 6340 KLTH0C08250p XP_002552581.1 701335 R 559295 CDS KLTH0C08272g 255712599 8291456 join(704892..704925,705000..705646) 1 NC_013079.1 highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism; KLTH0C08272p 705646 8291456 KLTH0C08272g Lachancea thermotolerans CBS 6340 KLTH0C08272p XP_002552582.1 704892 D 559295 CDS KLTH0C08294g 255712601 8291457 complement(705698..707443) 1 NC_013079.1 some similarities with uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity; KLTH0C08294p 707443 8291457 KLTH0C08294g Lachancea thermotolerans CBS 6340 KLTH0C08294p XP_002552583.1 705698 R 559295 CDS KLTH0C08316g 255712603 8291458 707550..708173 1 NC_013079.1 highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; KLTH0C08316p 708173 8291458 KLTH0C08316g Lachancea thermotolerans CBS 6340 KLTH0C08316p XP_002552584.1 707550 D 559295 CDS KLTH0C08338g 255712605 8291459 708532..709005 1 NC_013079.1 similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit; KLTH0C08338p 709005 8291459 KLTH0C08338g Lachancea thermotolerans CBS 6340 KLTH0C08338p XP_002552585.1 708532 D 559295 CDS KLTH0C08360g 255712607 8291460 709211..709978 1 NC_013079.1 similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome; KLTH0C08360p 709978 8291460 KLTH0C08360g Lachancea thermotolerans CBS 6340 KLTH0C08360p XP_002552586.1 709211 D 559295 CDS KLTH0C08382g 255712609 8291461 complement(710145..710564) 1 NC_013079.1 highly similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein; KLTH0C08382p 710564 8291461 KLTH0C08382g Lachancea thermotolerans CBS 6340 KLTH0C08382p XP_002552587.1 710145 R 559295 CDS KLTH0C08404g 255712611 8291462 711257..712048 1 NC_013079.1 conserved hypothetical protein; KLTH0C08404p 712048 8291462 KLTH0C08404g Lachancea thermotolerans CBS 6340 KLTH0C08404p XP_002552588.1 711257 D 559295 CDS KLTH0C08426g 255712613 8291463 complement(712136..713311) 1 NC_013079.1 weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons; KLTH0C08426p 713311 8291463 KLTH0C08426g Lachancea thermotolerans CBS 6340 KLTH0C08426p XP_002552589.1 712136 R 559295 CDS KLTH0C08448g 255712615 8291464 713441..714823 1 NC_013079.1 similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein-protein binding; KLTH0C08448p 714823 8291464 KLTH0C08448g Lachancea thermotolerans CBS 6340 KLTH0C08448p XP_002552590.1 713441 D 559295 CDS KLTH0C08470g 255712617 8291465 715134..716063 1 NC_013079.1 highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; KLTH0C08470p 716063 8291465 KLTH0C08470g Lachancea thermotolerans CBS 6340 KLTH0C08470p XP_002552591.1 715134 D 559295 CDS KLTH0C08492g 255712619 8291466 716689..717213 1 NC_013079.1 similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; KLTH0C08492p 717213 8291466 KLTH0C08492g Lachancea thermotolerans CBS 6340 KLTH0C08492p XP_002552592.1 716689 D 559295 CDS KLTH0C08514g 255712621 8291467 717495..717974 1 NC_013079.1 similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation; KLTH0C08514p 717974 8291467 KLTH0C08514g Lachancea thermotolerans CBS 6340 KLTH0C08514p XP_002552593.1 717495 D 559295 CDS KLTH0C08536g 255712623 8291468 718329..718616 1 NC_013079.1 similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit; KLTH0C08536p 718616 8291468 KLTH0C08536g Lachancea thermotolerans CBS 6340 KLTH0C08536p XP_002552594.1 718329 D 559295 CDS KLTH0C08558g 255712625 8291469 complement(718712..719635) 1 NC_013079.1 similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin; KLTH0C08558p 719635 8291469 KLTH0C08558g Lachancea thermotolerans CBS 6340 KLTH0C08558p XP_002552595.1 718712 R 559295 CDS KLTH0C08580g 255712627 8291470 complement(719781..721031) 1 NC_013079.1 similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription; KLTH0C08580p 721031 8291470 KLTH0C08580g Lachancea thermotolerans CBS 6340 KLTH0C08580p XP_002552596.1 719781 R 559295 CDS KLTH0C08602g 255712629 8291471 complement(721228..722883) 1 NC_013079.1 similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate; KLTH0C08602p 722883 8291471 KLTH0C08602g Lachancea thermotolerans CBS 6340 KLTH0C08602p XP_002552597.1 721228 R 559295 CDS KLTH0C08624g 255712631 8291472 complement(723206..724921) 1 NC_013079.1 conserved hypothetical protein; KLTH0C08624p 724921 8291472 KLTH0C08624g Lachancea thermotolerans CBS 6340 KLTH0C08624p XP_002552598.1 723206 R 559295 CDS KLTH0C08646g 255712633 8291473 725214..726557 1 NC_013079.1 similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p- Nuf2p-Spc24p- Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering; KLTH0C08646p 726557 8291473 KLTH0C08646g Lachancea thermotolerans CBS 6340 KLTH0C08646p XP_002552599.1 725214 D 559295 CDS KLTH0C08668g 255712635 8291474 complement(726594..727352) 1 NC_013079.1 similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly; KLTH0C08668p 727352 8291474 KLTH0C08668g Lachancea thermotolerans CBS 6340 KLTH0C08668p XP_002552600.1 726594 R 559295 CDS KLTH0C08690g 255712637 8291475 complement(727525..729255) 1 NC_013079.1 similar to uniprot|P06700 Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan plays roles in silencing at HML HMR telomeres and the rDNA locus negatively regulates initiation of DNA replication; KLTH0C08690p 729255 8291475 KLTH0C08690g Lachancea thermotolerans CBS 6340 KLTH0C08690p XP_002552601.1 727525 R 559295 CDS KLTH0C08712g 255712639 8291476 complement(729680..730231) 1 NC_013079.1 similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus; KLTH0C08712p 730231 8291476 KLTH0C08712g Lachancea thermotolerans CBS 6340 KLTH0C08712p XP_002552602.1 729680 R 559295 CDS KLTH0C08734g 255712641 8291477 complement(730381..732930) 1 NC_013079.1 similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing; KLTH0C08734p 732930 8291477 KLTH0C08734g Lachancea thermotolerans CBS 6340 KLTH0C08734p XP_002552603.1 730381 R 559295 CDS KLTH0C08756g 255712643 8291478 complement(733074..734906) 1 NC_013079.1 similar to uniprot|Q12362 Saccharomyces cerevisiae YOL066C Hypothetical ORF; KLTH0C08756p 734906 8291478 KLTH0C08756g Lachancea thermotolerans CBS 6340 KLTH0C08756p XP_002552604.1 733074 R 559295 CDS KLTH0C08778g 255712645 8291479 complement(734974..736092) 1 NC_013079.1 similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5- bisphosphate 5- phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins; KLTH0C08778p 736092 8291479 KLTH0C08778g Lachancea thermotolerans CBS 6340 KLTH0C08778p XP_002552605.1 734974 R 559295 CDS KLTH0C08800g 255712647 8291480 complement(736187..739039) 1 NC_013079.1 weakly similar to uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G-protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis; KLTH0C08800p 739039 8291480 KLTH0C08800g Lachancea thermotolerans CBS 6340 KLTH0C08800p XP_002552606.1 736187 R 559295 CDS KLTH0C08822g 255712649 8291481 complement(739352..740434) 1 NC_013079.1 similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'- phosphoadenosine- 5'-phosphosulfate intermediates of the sulfate assimilation pathway; KLTH0C08822p 740434 8291481 KLTH0C08822g Lachancea thermotolerans CBS 6340 KLTH0C08822p XP_002552607.1 739352 R 559295 CDS KLTH0C08844g 255712651 8291482 complement(741049..742329) 1 NC_013079.1 similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln; KLTH0C08844p 742329 8291482 KLTH0C08844g Lachancea thermotolerans CBS 6340 KLTH0C08844p XP_002552608.1 741049 R 559295 CDS KLTH0C08866g 255712653 8291483 742559..745477 1 NC_013079.1 highly similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family; KLTH0C08866p 745477 8291483 KLTH0C08866g Lachancea thermotolerans CBS 6340 KLTH0C08866p XP_002552609.1 742559 D 559295 CDS KLTH0C08888g 255712655 8291484 745663..747183 1 NC_013079.1 similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly; KLTH0C08888p 747183 8291484 KLTH0C08888g Lachancea thermotolerans CBS 6340 KLTH0C08888p XP_002552610.1 745663 D 559295 CDS KLTH0C08910g 255712657 8291485 747343..748662 1 NC_013079.1 similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP- diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP- diaclglyerol a critical step in the synthesis of all major yeast phospholipids; KLTH0C08910p 748662 8291485 KLTH0C08910g Lachancea thermotolerans CBS 6340 KLTH0C08910p XP_002552611.1 747343 D 559295 CDS KLTH0C08932g 255712659 8291486 749308..750867 1 NC_013079.1 similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF; KLTH0C08932p 750867 8291486 KLTH0C08932g Lachancea thermotolerans CBS 6340 KLTH0C08932p XP_002552612.1 749308 D 559295 CDS KLTH0C08954g 255712661 8291487 complement(750972..751334) 1 NC_013079.1 no similarity; KLTH0C08954p 751334 8291487 KLTH0C08954g Lachancea thermotolerans CBS 6340 KLTH0C08954p XP_002552613.1 750972 R 559295 CDS KLTH0C08976g 255712663 8291488 751731..753839 1 NC_013079.1 weakly similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; KLTH0C08976p 753839 8291488 KLTH0C08976g Lachancea thermotolerans CBS 6340 KLTH0C08976p XP_002552614.1 751731 D 559295 CDS KLTH0C08998g 255712665 8291489 complement(754506..755567) 1 NC_013079.1 similar to uniprot|Q4WG56 Aspergillus fumigatus Afu7g03850 Oxidoreductase 2-nitropropane dioxygenase family putative; KLTH0C08998p 755567 8291489 KLTH0C08998g Lachancea thermotolerans CBS 6340 KLTH0C08998p XP_002552615.1 754506 R 559295 CDS KLTH0C09020g 255712667 8291490 756619..757752 1 NC_013079.1 similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis; KLTH0C09020p 757752 8291490 KLTH0C09020g Lachancea thermotolerans CBS 6340 KLTH0C09020p XP_002552616.1 756619 D 559295 CDS KLTH0C09042g 255712669 8291491 complement(758149..759279) 1 NC_013079.1 similar to uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; KLTH0C09042p 759279 8291491 KLTH0C09042g Lachancea thermotolerans CBS 6340 KLTH0C09042p XP_002552617.1 758149 R 559295 CDS KLTH0C09086g 255712671 8291493 complement(join(759755..759867,759935..760166)) 1 NC_013079.1 similar to uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis forms a complex with Ino2p that binds the inositol-choline-responsive element through a basic helix-loop-helix domain; KLTH0C09086p 760166 8291493 KLTH0C09086g Lachancea thermotolerans CBS 6340 KLTH0C09086p XP_002552618.1 759755 R 559295 CDS KLTH0C09130g 255712673 8291495 761006..762004 1 NC_013079.1 similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF; KLTH0C09130p 762004 8291495 KLTH0C09130g Lachancea thermotolerans CBS 6340 KLTH0C09130p XP_002552619.1 761006 D 559295 CDS KLTH0C09152g 255712675 8291496 complement(762101..762973) 1 NC_013079.1 similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels; KLTH0C09152p 762973 8291496 KLTH0C09152g Lachancea thermotolerans CBS 6340 KLTH0C09152p XP_002552620.1 762101 R 559295 CDS KLTH0C09196g 255712677 8291498 complement(763731..765050) 1 NC_013079.1 some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC4; KLTH0C09196p 765050 8291498 KLTH0C09196g Lachancea thermotolerans CBS 6340 KLTH0C09196p XP_002552621.1 763731 R 559295 CDS KLTH0C09240g 255712679 8291500 complement(766620..771260) 1 NC_013079.1 similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p; KLTH0C09240p 771260 8291500 KLTH0C09240g Lachancea thermotolerans CBS 6340 KLTH0C09240p XP_002552622.1 766620 R 559295 CDS KLTH0C09262g 255712681 8291501 772193..772783 1 NC_013079.1 similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; KLTH0C09262p 772783 8291501 KLTH0C09262g Lachancea thermotolerans CBS 6340 KLTH0C09262p XP_002552623.1 772193 D 559295 CDS KLTH0C09284g 255712683 8291502 773048..773485 1 NC_013079.1 similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus; KLTH0C09284p 773485 8291502 KLTH0C09284g Lachancea thermotolerans CBS 6340 KLTH0C09284p XP_002552624.1 773048 D 559295 CDS KLTH0C09306g 255712685 8291503 complement(773612..774934) 1 NC_013079.1 similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions; KLTH0C09306p 774934 8291503 KLTH0C09306g Lachancea thermotolerans CBS 6340 KLTH0C09306p XP_002552625.1 773612 R 559295 CDS KLTH0C09328g 255712687 8291504 complement(775129..776121) 1 NC_013079.1 conserved hypothetical protein; KLTH0C09328p 776121 8291504 KLTH0C09328g Lachancea thermotolerans CBS 6340 KLTH0C09328p XP_002552626.1 775129 R 559295 CDS KLTH0C09350g 255712689 8291505 776304..777332 1 NC_013079.1 some similarities with uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p; KLTH0C09350p 777332 8291505 KLTH0C09350g Lachancea thermotolerans CBS 6340 KLTH0C09350p XP_002552627.1 776304 D 559295 CDS KLTH0C09372g 255712691 8291506 778251..780077 1 NC_013079.1 highly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; KLTH0C09372p 780077 8291506 KLTH0C09372g Lachancea thermotolerans CBS 6340 KLTH0C09372p XP_002552628.1 778251 D 559295 CDS KLTH0C09394g 255712693 8291507 780557..782530 1 NC_013079.1 similar to uniprot|Q04373 YDR496C Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences; KLTH0C09394p 782530 8291507 KLTH0C09394g Lachancea thermotolerans CBS 6340 KLTH0C09394p XP_002552629.1 780557 D 559295 CDS KLTH0C09416g 255712695 8291508 782703..785471 1 NC_013079.1 similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein; KLTH0C09416p 785471 8291508 KLTH0C09416g Lachancea thermotolerans CBS 6340 KLTH0C09416p XP_002552630.1 782703 D 559295 CDS KLTH0C09438g 255712697 8291509 complement(785549..786610) 1 NC_013079.1 weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation; KLTH0C09438p 786610 8291509 KLTH0C09438g Lachancea thermotolerans CBS 6340 KLTH0C09438p XP_002552631.1 785549 R 559295 CDS KLTH0C09460g 255712699 8291510 complement(786979..787656) 1 NC_013079.1 similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase; KLTH0C09460p 787656 8291510 KLTH0C09460g Lachancea thermotolerans CBS 6340 KLTH0C09460p XP_002552632.1 786979 R 559295 CDS KLTH0C09482g 255712701 8291511 complement(787911..788267) 1 NC_013079.1 similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae FMP36; KLTH0C09482p 788267 8291511 KLTH0C09482g Lachancea thermotolerans CBS 6340 KLTH0C09482p XP_002552633.1 787911 R 559295 CDS KLTH0C09504g 255712703 8291512 complement(788442..789401) 1 NC_013079.1 similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc; KLTH0C09504p 789401 8291512 KLTH0C09504g Lachancea thermotolerans CBS 6340 KLTH0C09504p XP_002552634.1 788442 R 559295 CDS KLTH0C09526g 255712705 8291513 complement(791169..791753) 1 NC_013079.1 conserved hypothetical protein; KLTH0C09526p 791753 8291513 KLTH0C09526g Lachancea thermotolerans CBS 6340 KLTH0C09526p XP_002552635.1 791169 R 559295 CDS KLTH0C09548g 255712707 8291514 792218..795199 1 NC_013079.1 similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; KLTH0C09548p 795199 8291514 KLTH0C09548g Lachancea thermotolerans CBS 6340 KLTH0C09548p XP_002552636.1 792218 D 559295 CDS KLTH0C09570g 255712709 8291515 complement(795587..798715) 1 NC_013079.1 similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF; KLTH0C09570p 798715 8291515 KLTH0C09570g Lachancea thermotolerans CBS 6340 KLTH0C09570p XP_002552637.1 795587 R 559295 CDS KLTH0C09614g 255712711 8291627 complement(799426..800310) 1 NC_013079.1 similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; KLTH0C09614p 800310 8291627 KLTH0C09614g Lachancea thermotolerans CBS 6340 KLTH0C09614p XP_002552638.1 799426 R 559295 CDS KLTH0C09636g 255712713 8291517 800421..802229 1 NC_013079.1 weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8; KLTH0C09636p 802229 8291517 KLTH0C09636g Lachancea thermotolerans CBS 6340 KLTH0C09636p XP_002552639.1 800421 D 559295 CDS KLTH0C09702g 255712715 8291520 complement(802885..803391) 1 NC_013079.1 no similarity; KLTH0C09702p 803391 8291520 KLTH0C09702g Lachancea thermotolerans CBS 6340 KLTH0C09702p XP_002552640.1 802885 R 559295 CDS KLTH0C09724g 255712717 8291521 complement(806399..806596) 1 NC_013079.1 conserved hypothetical protein; KLTH0C09724p 806596 8291521 KLTH0C09724g Lachancea thermotolerans CBS 6340 KLTH0C09724p XP_002552641.1 806399 R 559295 CDS KLTH0C09746g 255712719 8291522 807458..808096 1 NC_013079.1 highly similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4- phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration; KLTH0C09746p 808096 8291522 KLTH0C09746g Lachancea thermotolerans CBS 6340 KLTH0C09746p XP_002552642.1 807458 D 559295 CDS KLTH0C09768g 255712721 8291523 complement(808196..809476) 1 NC_013079.1 highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA; KLTH0C09768p 809476 8291523 KLTH0C09768g Lachancea thermotolerans CBS 6340 KLTH0C09768p XP_002552643.1 808196 R 559295 CDS KLTH0C09790g 255712723 8291524 810128..810811 1 NC_013079.1 similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative); KLTH0C09790p 810811 8291524 KLTH0C09790g Lachancea thermotolerans CBS 6340 KLTH0C09790p XP_002552644.1 810128 D 559295 CDS KLTH0C09812g 255712725 8291525 complement(810850..811770) 1 NC_013079.1 similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C; KLTH0C09812p 811770 8291525 KLTH0C09812g Lachancea thermotolerans CBS 6340 KLTH0C09812p XP_002552645.1 810850 R 559295 CDS KLTH0C09834g 255712727 8291526 812005..814098 1 NC_013079.1 weakly similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting; KLTH0C09834p 814098 8291526 KLTH0C09834g Lachancea thermotolerans CBS 6340 KLTH0C09834p XP_002552646.1 812005 D 559295 CDS KLTH0C09856g 255712729 8291527 complement(814145..816286) 1 NC_013079.1 similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP- dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription; KLTH0C09856p 816286 8291527 KLTH0C09856g Lachancea thermotolerans CBS 6340 KLTH0C09856p XP_002552647.1 814145 R 559295 CDS KLTH0C09878g 255712731 8291528 complement(816450..818222) 1 NC_013079.1 similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W; KLTH0C09878p 818222 8291528 KLTH0C09878g Lachancea thermotolerans CBS 6340 KLTH0C09878p XP_002552648.1 816450 R 559295 CDS KLTH0C09900g 255712733 8291529 complement(818369..819337) 1 NC_013079.1 highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; KLTH0C09900p 819337 8291529 KLTH0C09900g Lachancea thermotolerans CBS 6340 KLTH0C09900p XP_002552649.1 818369 R 559295 CDS KLTH0C09922g 255712735 8291530 819571..820479 1 NC_013079.1 similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W; KLTH0C09922p 820479 8291530 KLTH0C09922g Lachancea thermotolerans CBS 6340 KLTH0C09922p XP_002552650.1 819571 D 559295 CDS KLTH0C09944g 255712737 8291531 822021..822947 1 NC_013079.1 similar to uniprot|Q12010 YOL092W Saccharomyces cerevisiae Hypothetical ORF; KLTH0C09944p 822947 8291531 KLTH0C09944g Lachancea thermotolerans CBS 6340 KLTH0C09944p XP_002552651.1 822021 D 559295 CDS KLTH0C09966g 255712739 8291532 823260..825542 1 NC_013079.1 conserved hypothetical protein; KLTH0C09966p 825542 8291532 KLTH0C09966g Lachancea thermotolerans CBS 6340 KLTH0C09966p XP_002552652.1 823260 D 559295 CDS KLTH0C09988g 255712741 8291533 825726..828593 1 NC_013079.1 highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process contains a Walker ATP- binding motif required for repair activity Msh2p-Msh6p binds to and hydrolyzes ATP; KLTH0C09988p 828593 8291533 KLTH0C09988g Lachancea thermotolerans CBS 6340 KLTH0C09988p XP_002552653.1 825726 D 559295 CDS KLTH0C10010g 255712743 8291534 829145..830110 1 NC_013079.1 similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified; KLTH0C10010p 830110 8291534 KLTH0C10010g Lachancea thermotolerans CBS 6340 KLTH0C10010p XP_002552654.1 829145 D 559295 CDS KLTH0C10032g 255712745 8291535 complement(830334..832934) 1 NC_013079.1 weakly similar to uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; KLTH0C10032p 832934 8291535 KLTH0C10032g Lachancea thermotolerans CBS 6340 KLTH0C10032p XP_002552655.1 830334 R 559295 CDS KLTH0C10054g 255712747 8291536 834498..835406 1 NC_013079.1 similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus; KLTH0C10054p 835406 8291536 KLTH0C10054g Lachancea thermotolerans CBS 6340 KLTH0C10054p XP_002552656.1 834498 D 559295 CDS KLTH0C10076g 255712749 8291537 complement(835443..836180) 1 NC_013079.1 weakly similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family exhibits chaperone activity overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions undergoes oxidation by Ero1p; KLTH0C10076p 836180 8291537 KLTH0C10076g Lachancea thermotolerans CBS 6340 KLTH0C10076p XP_002552657.1 835443 R 559295 CDS KLTH0C10098g 255712751 8291538 complement(836528..838843) 1 NC_013079.1 weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrr1p acting on an overlapping set of target genes; KLTH0C10098p 838843 8291538 KLTH0C10098g Lachancea thermotolerans CBS 6340 KLTH0C10098p XP_002552658.1 836528 R 559295 CDS KLTH0C10120g 255712753 8291539 839780..841735 1 NC_013079.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation; KLTH0C10120p 841735 8291539 KLTH0C10120g Lachancea thermotolerans CBS 6340 KLTH0C10120p XP_002552659.1 839780 D 559295 CDS KLTH0C10142g 255712755 8291540 842371..844092 1 NC_013079.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation; KLTH0C10142p 844092 8291540 KLTH0C10142g Lachancea thermotolerans CBS 6340 KLTH0C10142p XP_002552660.1 842371 D 559295 CDS KLTH0C10164g 255712757 8291541 844475..845380 1 NC_013079.1 conserved hypothetical protein; KLTH0C10164p 845380 8291541 KLTH0C10164g Lachancea thermotolerans CBS 6340 KLTH0C10164p XP_002552661.1 844475 D 559295 CDS KLTH0C10186g 255712759 8291542 846014..846550 1 NC_013079.1 similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates; KLTH0C10186p 846550 8291542 KLTH0C10186g Lachancea thermotolerans CBS 6340 KLTH0C10186p XP_002552662.1 846014 D 559295 CDS KLTH0C10208g 255712761 8291543 complement(846933..847844) 1 NC_013079.1 similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF; KLTH0C10208p 847844 8291543 KLTH0C10208g Lachancea thermotolerans CBS 6340 KLTH0C10208p XP_002552663.1 846933 R 559295 CDS KLTH0C10230g 255712763 8291544 847951..850302 1 NC_013079.1 similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1; KLTH0C10230p 850302 8291544 KLTH0C10230g Lachancea thermotolerans CBS 6340 KLTH0C10230p XP_002552664.1 847951 D 559295 CDS KLTH0C10252g 255712765 8291545 850445..851542 1 NC_013079.1 conserved hypothetical protein; KLTH0C10252p 851542 8291545 KLTH0C10252g Lachancea thermotolerans CBS 6340 KLTH0C10252p XP_002552665.1 850445 D 559295 CDS KLTH0C10274g 255712767 8291546 complement(851565..852866) 1 NC_013079.1 similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF; KLTH0C10274p 852866 8291546 KLTH0C10274g Lachancea thermotolerans CBS 6340 KLTH0C10274p XP_002552666.1 851565 R 559295 CDS KLTH0C10296g 255712769 8291547 complement(854674..854877) 1 NC_013079.1 highly similar to uniprot|P0C0X0 Saccharomyces cerevisiae YLR264W RPS28B or highly similar to uniprot|Q3E7X9 Saccharomyces cerevisiae YOR167C RPS28A; KLTH0C10296p 854877 8291547 KLTH0C10296g Lachancea thermotolerans CBS 6340 KLTH0C10296p XP_002552667.1 854674 R 559295 CDS KLTH0C10318g 255712771 8291548 complement(join(855121..857157,857236..857520)) 1 NC_013079.1 weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein involved in chromosome segregation during the first meiotic division; KLTH0C10318p 857520 8291548 KLTH0C10318g Lachancea thermotolerans CBS 6340 KLTH0C10318p XP_002552668.1 855121 R 559295 CDS KLTH0C10340g 255712773 8291549 857898..860300 1 NC_013079.1 highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions; KLTH0C10340p 860300 8291549 KLTH0C10340g Lachancea thermotolerans CBS 6340 KLTH0C10340p XP_002552669.1 857898 D 559295 CDS KLTH0C10362g 255712775 8291550 860484..860678 1 NC_013079.1 highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A TMA7; KLTH0C10362p 860678 8291550 KLTH0C10362g Lachancea thermotolerans CBS 6340 KLTH0C10362p XP_002552670.1 860484 D 559295 CDS KLTH0C10384g 255712777 8291551 861122..861826 1 NC_013079.1 highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6; KLTH0C10384p 861826 8291551 KLTH0C10384g Lachancea thermotolerans CBS 6340 KLTH0C10384p XP_002552671.1 861122 D 559295 CDS KLTH0C10406g 255712779 8291552 complement(862020..863681) 1 NC_013079.1 similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long- chain base phosphates which function as signaling molecules and similar to YOR171c; KLTH0C10406p 863681 8291552 KLTH0C10406g Lachancea thermotolerans CBS 6340 KLTH0C10406p XP_002552672.1 862020 R 559295 CDS KLTH0C10428g 255712781 8291553 865513..867219 1 NC_013079.1 highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL; KLTH0C10428p 867219 8291553 KLTH0C10428g Lachancea thermotolerans CBS 6340 KLTH0C10428p XP_002552673.1 865513 D 559295 CDS KLTH0C10450g 255712783 8291554 complement(867872..869572) 1 NC_013079.1 conserved hypothetical protein; KLTH0C10450p 869572 8291554 KLTH0C10450g Lachancea thermotolerans CBS 6340 KLTH0C10450p XP_002552674.1 867872 R 559295 CDS KLTH0C10494g 255712785 8291556 870639..870896 1 NC_013079.1 conserved hypothetical protein; KLTH0C10494p 870896 8291556 KLTH0C10494g Lachancea thermotolerans CBS 6340 KLTH0C10494p XP_002552675.1 870639 D 559295 CDS KLTH0C10516g 255712787 8291557 871091..872776 1 NC_013079.1 similar to uniprot|P23172 Saccharomyces cerevisiae YOR380W RDR1 Transcriptional repressor involved in the control of multidrug resistance negatively regulates expression of the PDR5 gene member of the Gal4p family of zinc cluster proteins; KLTH0C10516p 872776 8291557 KLTH0C10516g Lachancea thermotolerans CBS 6340 KLTH0C10516p XP_002552676.1 871091 D 559295 CDS KLTH0C10538g 255712789 8291558 complement(873623..874444) 1 NC_013079.1 conserved hypothetical protein; KLTH0C10538p 874444 8291558 KLTH0C10538g Lachancea thermotolerans CBS 6340 KLTH0C10538p XP_002552677.1 873623 R 559295 CDS KLTH0C10560g 255712791 8291559 875216..876763 1 NC_013079.1 similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W Hypothetical ORF; KLTH0C10560p 876763 8291559 KLTH0C10560g Lachancea thermotolerans CBS 6340 KLTH0C10560p XP_002552678.1 875216 D 559295 CDS KLTH0C10582g 255712793 8291560 877398..878843 1 NC_013079.1 similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor; KLTH0C10582p 878843 8291560 KLTH0C10582g Lachancea thermotolerans CBS 6340 KLTH0C10582p XP_002552679.1 877398 D 559295 CDS KLTH0C10604g 255712795 8291561 complement(878953..880500) 1 NC_013079.1 similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger; KLTH0C10604p 880500 8291561 KLTH0C10604g Lachancea thermotolerans CBS 6340 KLTH0C10604p XP_002552680.1 878953 R 559295 CDS KLTH0C10626g 255712797 8291562 880732..881151 1 NC_013079.1 conserved hypothetical protein; KLTH0C10626p 881151 8291562 KLTH0C10626g Lachancea thermotolerans CBS 6340 KLTH0C10626p XP_002552681.1 880732 D 559295 CDS KLTH0C10648g 255712799 8291563 complement(881350..881754) 1 NC_013079.1 highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin; KLTH0C10648p 881754 8291563 KLTH0C10648g Lachancea thermotolerans CBS 6340 KLTH0C10648p XP_002552682.1 881350 R 559295 CDS KLTH0C10670g 255712801 8291564 882520..884478 1 NC_013079.1 similar to uniprot|P39105 Saccharomyces cerevisiae YMR008C PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; KLTH0C10670p 884478 8291564 KLTH0C10670g Lachancea thermotolerans CBS 6340 KLTH0C10670p XP_002552683.1 882520 D 559295 CDS KLTH0C10714g 255712803 8291566 complement(885055..886287) 1 NC_013079.1 similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate; KLTH0C10714p 886287 8291566 KLTH0C10714g Lachancea thermotolerans CBS 6340 KLTH0C10714p XP_002552684.1 885055 R 559295 CDS KLTH0C10736g 255712805 8291567 886518..887612 1 NC_013079.1 highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase- like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity; KLTH0C10736p 887612 8291567 KLTH0C10736g Lachancea thermotolerans CBS 6340 KLTH0C10736p XP_002552685.1 886518 D 559295 CDS KLTH0C10758g 255712807 8291568 complement(887737..889305) 1 NC_013079.1 similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; KLTH0C10758p 889305 8291568 KLTH0C10758g Lachancea thermotolerans CBS 6340 KLTH0C10758p XP_002552686.1 887737 R 559295 CDS KLTH0C10780g 255712809 8291569 complement(889534..890340) 1 NC_013079.1 similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae; KLTH0C10780p 890340 8291569 KLTH0C10780g Lachancea thermotolerans CBS 6340 KLTH0C10780p XP_002552687.1 889534 R 559295 CDS KLTH0C10802g 255712811 8291570 890455..891060 1 NC_013079.1 similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF; KLTH0C10802p 891060 8291570 KLTH0C10802g Lachancea thermotolerans CBS 6340 KLTH0C10802p XP_002552688.1 890455 D 559295 CDS KLTH0C10824g 255712813 8291571 complement(891260..892060) 1 NC_013079.1 weakly similar to uniprot|Q03673 Saccharomyces cerevisiae YMR003W Hypothetical ORF; KLTH0C10824p 892060 8291571 KLTH0C10824g Lachancea thermotolerans CBS 6340 KLTH0C10824p XP_002552689.1 891260 R 559295 CDS KLTH0C10846g 255712815 8291572 complement(892459..892920) 1 NC_013079.1 similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF; KLTH0C10846p 892920 8291572 KLTH0C10846g Lachancea thermotolerans CBS 6340 KLTH0C10846p XP_002552690.1 892459 R 559295 CDS KLTH0C10868g 255712817 8291573 complement(893158..894057) 1 NC_013079.1 some similarities with uniprot|Q08054 Saccharomyces cerevisiae YOL007C Appears to be a structural component of the chitin synthase 3 complex; KLTH0C10868p 894057 8291573 KLTH0C10868g Lachancea thermotolerans CBS 6340 KLTH0C10868p XP_002552691.1 893158 R 559295 CDS KLTH0C10890g 255712819 8291574 complement(894335..896605) 1 NC_013079.1 similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I; KLTH0C10890p 896605 8291574 KLTH0C10890g Lachancea thermotolerans CBS 6340 KLTH0C10890p XP_002552692.1 894335 R 559295 CDS KLTH0C10912g 255712821 8291575 898372..900465 1 NC_013079.1 highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C; KLTH0C10912p 900465 8291575 KLTH0C10912g Lachancea thermotolerans CBS 6340 KLTH0C10912p XP_002552693.1 898372 D 559295 CDS KLTH0C10934g 255712823 8291576 complement(900683..901051) 1 NC_013079.1 highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C; KLTH0C10934p 901051 8291576 KLTH0C10934g Lachancea thermotolerans CBS 6340 KLTH0C10934p XP_002552694.1 900683 R 559295 CDS KLTH0C10956g 255712825 8291577 901384..905685 1 NC_013079.1 similar to uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation; KLTH0C10956p 905685 8291577 KLTH0C10956g Lachancea thermotolerans CBS 6340 KLTH0C10956p XP_002552695.1 901384 D 559295 CDS KLTH0C10978g 255712827 8291578 complement(905760..906893) 1 NC_013079.1 similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC-CRD protein; KLTH0C10978p 906893 8291578 KLTH0C10978g Lachancea thermotolerans CBS 6340 KLTH0C10978p XP_002552696.1 905760 R 559295 CDS KLTH0C11044g 255712829 8291581 complement(908604..909551) 1 NC_013079.1 similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc; KLTH0C11044p 909551 8291581 KLTH0C11044g Lachancea thermotolerans CBS 6340 KLTH0C11044p XP_002552697.1 908604 R 559295 CDS KLTH0C11066g 255712831 8291582 complement(910359..912566) 1 NC_013079.1 similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus; KLTH0C11066p 912566 8291582 KLTH0C11066g Lachancea thermotolerans CBS 6340 KLTH0C11066p XP_002552698.1 910359 R 559295 CDS KLTH0C11110g 255712833 8291584 complement(914257..915099) 1 NC_013079.1 similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance; KLTH0C11110p 915099 8291584 KLTH0C11110g Lachancea thermotolerans CBS 6340 KLTH0C11110p XP_002552699.1 914257 R 559295 CDS KLTH0C11132g 255712835 8291585 complement(915337..915963) 1 NC_013079.1 highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family; KLTH0C11132p 915963 8291585 KLTH0C11132g Lachancea thermotolerans CBS 6340 KLTH0C11132p XP_002552700.1 915337 R 559295 CDS KLTH0C11154g 255712837 8291586 916374..917291 1 NC_013079.1 conserved hypothetical protein; KLTH0C11154p 917291 8291586 KLTH0C11154g Lachancea thermotolerans CBS 6340 KLTH0C11154p XP_002552701.1 916374 D 559295 CDS KLTH0C11176g 255712839 8291587 917419..919029 1 NC_013079.1 similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease; KLTH0C11176p 919029 8291587 KLTH0C11176g Lachancea thermotolerans CBS 6340 KLTH0C11176p XP_002552702.1 917419 D 559295 CDS KLTH0C11220g 255712841 8291589 920972..921955 1 NC_013079.1 similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans; KLTH0C11220p 921955 8291589 KLTH0C11220g Lachancea thermotolerans CBS 6340 KLTH0C11220p XP_002552703.1 920972 D 559295 CDS KLTH0C11242g 255712843 8291590 complement(921970..925263) 1 NC_013079.1 similar to uniprot|Q04263 Saccharomyces cerevisiae YML002W Hypothetical ORF; KLTH0C11242p 925263 8291590 KLTH0C11242g Lachancea thermotolerans CBS 6340 KLTH0C11242p XP_002552704.1 921970 R 559295 CDS KLTH0C11264g 255712845 8291591 925534..926574 1 NC_013079.1 similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF; KLTH0C11264p 926574 8291591 KLTH0C11264g Lachancea thermotolerans CBS 6340 KLTH0C11264p XP_002552705.1 925534 D 559295 CDS KLTH0C11286g 255712847 8291592 926742..929597 1 NC_013079.1 similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end- joining (NHEJ) forms stable heterodimer with required cofactor Lif1p catalyzes DNA ligation as part of a complex with Lif1p and Nej1p involved in meiosis not essential for vegetative growth; KLTH0C11286p 929597 8291592 KLTH0C11286g Lachancea thermotolerans CBS 6340 KLTH0C11286p XP_002552706.1 926742 D 559295 CDS KLTH0C11308g 255712849 8291593 929710..931782 1 NC_013079.1 similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences; KLTH0C11308p 931782 8291593 KLTH0C11308g Lachancea thermotolerans CBS 6340 KLTH0C11308p XP_002552707.1 929710 D 559295 CDS KLTH0C11330g 255712851 8291594 complement(931865..934690) 1 NC_013079.1 similar to uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; KLTH0C11330p 934690 8291594 KLTH0C11330g Lachancea thermotolerans CBS 6340 KLTH0C11330p XP_002552708.1 931865 R 559295 CDS KLTH0C11352g 255712853 8291595 complement(934886..935692) 1 NC_013079.1 similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability; KLTH0C11352p 935692 8291595 KLTH0C11352g Lachancea thermotolerans CBS 6340 KLTH0C11352p XP_002552709.1 934886 R 559295 CDS KLTH0C11374g 255712855 8291596 complement(935901..936518) 1 NC_013079.1 conserved hypothetical protein; KLTH0C11374p 936518 8291596 KLTH0C11374g Lachancea thermotolerans CBS 6340 KLTH0C11374p XP_002552710.1 935901 R 559295 CDS KLTH0C11396g 255712857 8291597 complement(936878..938530) 1 NC_013079.1 similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation; KLTH0C11396p 938530 8291597 KLTH0C11396g Lachancea thermotolerans CBS 6340 KLTH0C11396p XP_002552711.1 936878 R 559295 CDS KLTH0C11440g 255712859 8291599 complement(940466..941992) 1 NC_013079.1 similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase may play a role in steroid detoxification forms volatile esters during fermentation which is important in brewing; KLTH0C11440p 941992 8291599 KLTH0C11440g Lachancea thermotolerans CBS 6340 KLTH0C11440p XP_002552712.1 940466 R 559295 CDS KLTH0C11462g 255712861 8291600 complement(942263..943741) 1 NC_013079.1 highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; KLTH0C11462p 943741 8291600 KLTH0C11462g Lachancea thermotolerans CBS 6340 KLTH0C11462p XP_002552713.1 942263 R 559295 CDS KLTH0C11484g 255712863 8291601 complement(944502..944771) 1 NC_013079.1 similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A SOM1 Protein whose overexpression suppresses the imp1 mutation may be required for the function of the Imp1p mitochondrial inner membrane peptidase and/or the protein sorting machinery; KLTH0C11484p 944771 8291601 KLTH0C11484g Lachancea thermotolerans CBS 6340 KLTH0C11484p XP_002552714.1 944502 R 559295 CDS KLTH0C11506g 255712865 8291602 944869..946503 1 NC_013079.1 similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine- phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin; KLTH0C11506p 946503 8291602 KLTH0C11506g Lachancea thermotolerans CBS 6340 KLTH0C11506p XP_002552715.1 944869 D 559295 CDS KLTH0C11528g 255712867 8291603 946632..948560 1 NC_013079.1 similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function; KLTH0C11528p 948560 8291603 KLTH0C11528g Lachancea thermotolerans CBS 6340 KLTH0C11528p XP_002552716.1 946632 D 559295 CDS KLTH0C11550g 255712869 8291604 949063..950259 1 NC_013079.1 similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W; KLTH0C11550p 950259 8291604 KLTH0C11550g Lachancea thermotolerans CBS 6340 KLTH0C11550p XP_002552717.1 949063 D 559295 CDS KLTH0C11572g 255712871 8291605 complement(950297..951853) 1 NC_013079.1 similar to uniprot|Q08984 Saccharomyces cerevisiae YPL272C Hypothetical ORF; KLTH0C11572p 951853 8291605 KLTH0C11572g Lachancea thermotolerans CBS 6340 KLTH0C11572p XP_002552718.1 950297 R 559295 CDS KLTH0C11594g 255712873 8291606 complement(952163..955183) 1 NC_013079.1 similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C; KLTH0C11594p 955183 8291606 KLTH0C11594g Lachancea thermotolerans CBS 6340 KLTH0C11594p XP_002552719.1 952163 R 559295 CDS KLTH0C11616g 255712875 8291607 956011..958233 1 NC_013079.1 similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane; KLTH0C11616p 958233 8291607 KLTH0C11616g Lachancea thermotolerans CBS 6340 KLTH0C11616p XP_002552720.1 956011 D 559295 CDS KLTH0C11638g 255712877 8291608 958488..960137 1 NC_013079.1 weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase; KLTH0C11638p 960137 8291608 KLTH0C11638g Lachancea thermotolerans CBS 6340 KLTH0C11638p XP_002552721.1 958488 D 559295 CDS KLTH0C11660g 255712879 8291609 960335..962890 1 NC_013079.1 some similarities with uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide- specific phospholipase C hydrolyzes phosphatidylinositol 4 5- biphosphate (PIP2) to generate inositol 1 4 5- triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation; KLTH0C11660p 962890 8291609 KLTH0C11660g Lachancea thermotolerans CBS 6340 KLTH0C11660p XP_002552722.1 960335 D 559295 CDS KLTH0C11682g 255712881 8291610 965848..966465 1 NC_013079.1 weakly similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1; KLTH0C11682p 966465 8291610 KLTH0C11682g Lachancea thermotolerans CBS 6340 KLTH0C11682p XP_002552723.1 965848 D 559295 CDS KLTH0C11704g 255712883 8291611 966706..967674 1 NC_013079.1 highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'- terminal loop of 18 S rRNA part of 90S and 40S pre- particles in nucleolus involved in pre-ribosomal RNA processing; KLTH0C11704p 967674 8291611 KLTH0C11704g Lachancea thermotolerans CBS 6340 KLTH0C11704p XP_002552724.1 966706 D 559295 CDS KLTH0C11770g 255712885 8291614 970979..972835 1 NC_013079.1 similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions; KLTH0C11770p 972835 8291614 KLTH0C11770g Lachancea thermotolerans CBS 6340 KLTH0C11770p XP_002552725.1 970979 D 559295 CDS KLTH0C11836g 255712887 8291617 976791..978212 1 NC_013079.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; KLTH0C11836p 978212 8291617 KLTH0C11836g Lachancea thermotolerans CBS 6340 KLTH0C11836p XP_002552726.1 976791 D 559295 CDS KLTH0C11858g 255712889 8291618 979073..980740 1 NC_013079.1 similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions; KLTH0C11858p 980740 8291618 KLTH0C11858g Lachancea thermotolerans CBS 6340 KLTH0C11858p XP_002552727.1 979073 D 559295 CDS KLTH0C11880g 255712891 8291619 complement(982966..983361) 1 NC_013079.1 conserved hypothetical protein; KLTH0C11880p 983361 8291619 KLTH0C11880g Lachancea thermotolerans CBS 6340 KLTH0C11880p XP_002552728.1 982966 R 559295 CDS KLTH0C11902g 255712893 8291620 983840..984871 1 NC_013079.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF; KLTH0C11902p 984871 8291620 KLTH0C11902g Lachancea thermotolerans CBS 6340 KLTH0C11902p XP_002552729.1 983840 D 559295 CDS KLTH0C11924g 255712895 8291621 987757..989166 1 NC_013079.1 some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W; KLTH0C11924p 989166 8291621 KLTH0C11924g Lachancea thermotolerans CBS 6340 KLTH0C11924p XP_002552730.1 987757 D 559295 CDS KLTH0C11946g 255712897 8291622 991279..992616 1 NC_013079.1 conserved hypothetical protein; KLTH0C11946p 992616 8291622 KLTH0C11946g Lachancea thermotolerans CBS 6340 KLTH0C11946p XP_002552731.1 991279 D 559295 CDS KLTH0C11968g 255712899 8291623 993683..995005 1 NC_013079.1 highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF; KLTH0C11968p 995005 8291623 KLTH0C11968g Lachancea thermotolerans CBS 6340 KLTH0C11968p XP_002552732.1 993683 D 559295 CDS KLTH0D00110g 255712902 8294947 796..2658 1 NC_013080.1 similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C; KLTH0D00110p 2658 8294947 KLTH0D00110g Lachancea thermotolerans CBS 6340 KLTH0D00110p XP_002552733.1 796 D 559295 CDS KLTH0D00132g 255712904 8294948 complement(2951..6727) 1 NC_013080.1 no similarity; KLTH0D00132p 6727 8294948 KLTH0D00132g Lachancea thermotolerans CBS 6340 KLTH0D00132p XP_002552734.1 2951 R 559295 CDS KLTH0D00198g 255712906 8294951 complement(12199..13608) 1 NC_013080.1 similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin; KLTH0D00198p 13608 8294951 KLTH0D00198g Lachancea thermotolerans CBS 6340 KLTH0D00198p XP_002552735.1 12199 R 559295 CDS KLTH0D00220g 255712908 8294952 complement(17298..17885) 1 NC_013080.1 highly similar to uniprot|P40893 Saccharomyces cerevisiae YJL217W Hypothetical ORF; KLTH0D00220p 17885 8294952 KLTH0D00220g Lachancea thermotolerans CBS 6340 KLTH0D00220p XP_002552736.1 17298 R 559295 CDS KLTH0D00242g 255712910 8294953 complement(20418..21098) 1 NC_013080.1 some similarities with uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins; KLTH0D00242p 21098 8294953 KLTH0D00242g Lachancea thermotolerans CBS 6340 KLTH0D00242p XP_002552737.1 20418 R 559295 CDS KLTH0D00264g 255712912 8294954 complement(21321..22868) 1 NC_013080.1 similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 Putative purine-cytosine permease; KLTH0D00264p 22868 8294954 KLTH0D00264g Lachancea thermotolerans CBS 6340 KLTH0D00264p XP_002552738.1 21321 R 559295 CDS KLTH0D00308g 255712914 8294956 complement(28125..28883) 1 NC_013080.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH; KLTH0D00308p 28883 8294956 KLTH0D00308g Lachancea thermotolerans CBS 6340 KLTH0D00308p XP_002552739.1 28125 R 559295 CDS KLTH0D00374g 255712916 8294959 complement(33818..34939) 1 NC_013080.1 weakly similar to uniprot|P53344 Saccharomyces cerevisiae YGR295C COS6 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins; KLTH0D00374p 34939 8294959 KLTH0D00374g Lachancea thermotolerans CBS 6340 KLTH0D00374p XP_002552740.1 33818 R 559295 CDS KLTH0D00396g 255712918 8294960 35809..37278 1 NC_013080.1 similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; KLTH0D00396p 37278 8294960 KLTH0D00396g Lachancea thermotolerans CBS 6340 KLTH0D00396p XP_002552741.1 35809 D 559295 CDS KLTH0D00418g 255712920 8294961 complement(37778..39463) 1 NC_013080.1 similar to uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase; KLTH0D00418p 39463 8294961 KLTH0D00418g Lachancea thermotolerans CBS 6340 KLTH0D00418p XP_002552742.1 37778 R 559295 CDS KLTH0D00440g 255712922 8294962 complement(40316..41296) 1 NC_013080.1 conserved hypothetical protein; KLTH0D00440p 41296 8294962 KLTH0D00440g Lachancea thermotolerans CBS 6340 KLTH0D00440p XP_002552743.1 40316 R 559295 CDS KLTH0D00484g 255712924 8294964 complement(44278..45819) 1 NC_013080.1 similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor; KLTH0D00484p 45819 8294964 KLTH0D00484g Lachancea thermotolerans CBS 6340 KLTH0D00484p XP_002552744.1 44278 R 559295 CDS KLTH0D00506g 255712926 8294965 47320..49170 1 NC_013080.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores; KLTH0D00506p 49170 8294965 KLTH0D00506g Lachancea thermotolerans CBS 6340 KLTH0D00506p XP_002552745.1 47320 D 559295 CDS KLTH0D00528g 255712928 8294966 50179..50808 1 NC_013080.1 conserved hypothetical protein; KLTH0D00528p 50808 8294966 KLTH0D00528g Lachancea thermotolerans CBS 6340 KLTH0D00528p XP_002552746.1 50179 D 559295 CDS KLTH0D00550g 255712930 8294967 51882..53270 1 NC_013080.1 highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesize glutamate from ammonia and alpha- ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; KLTH0D00550p 53270 8294967 KLTH0D00550g Lachancea thermotolerans CBS 6340 KLTH0D00550p XP_002552747.1 51882 D 559295 CDS KLTH0D00572g 255712932 8294968 complement(53475..55136) 1 NC_013080.1 weakly similar to uniprot|P54862 Saccharomyces cerevisiae YOL156W HXT11 Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance; KLTH0D00572p 55136 8294968 KLTH0D00572g Lachancea thermotolerans CBS 6340 KLTH0D00572p XP_002552748.1 53475 R 559295 CDS KLTH0D00594g 255712934 8294969 57414..59309 1 NC_013080.1 conserved hypothetical protein; KLTH0D00594p 59309 8294969 KLTH0D00594g Lachancea thermotolerans CBS 6340 KLTH0D00594p XP_002552749.1 57414 D 559295 CDS KLTH0D00616g 255712936 8294970 59883..61031 1 NC_013080.1 similar to uniprot|P39713 Saccharomyces cerevisiae YAL061W putative polyol dehydrogenase; KLTH0D00616p 61031 8294970 KLTH0D00616g Lachancea thermotolerans CBS 6340 KLTH0D00616p XP_002552750.1 59883 D 559295 CDS KLTH0D00638g 255712938 8294971 61224..61775 1 NC_013080.1 similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export; KLTH0D00638p 61775 8294971 KLTH0D00638g Lachancea thermotolerans CBS 6340 KLTH0D00638p XP_002552751.1 61224 D 559295 CDS KLTH0D00660g 255712940 8294972 62142..62582 1 NC_013080.1 conserved hypothetical protein; KLTH0D00660p 62582 8294972 KLTH0D00660g Lachancea thermotolerans CBS 6340 KLTH0D00660p XP_002552752.1 62142 D 559295 CDS KLTH0D00682g 255712942 8294973 complement(63033..64601) 1 NC_013080.1 highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed; KLTH0D00682p 64601 8294973 KLTH0D00682g Lachancea thermotolerans CBS 6340 KLTH0D00682p XP_002552753.1 63033 R 559295 CDS KLTH0D00704g 255712944 8294974 complement(65886..68045) 1 NC_013080.1 weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque required for exit from mitosis; KLTH0D00704p 68045 8294974 KLTH0D00704g Lachancea thermotolerans CBS 6340 KLTH0D00704p XP_002552754.1 65886 R 559295 CDS KLTH0D00726g 255712946 8294975 68287..69699 1 NC_013080.1 weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division; KLTH0D00726p 69699 8294975 KLTH0D00726g Lachancea thermotolerans CBS 6340 KLTH0D00726p XP_002552755.1 68287 D 559295 CDS KLTH0D00748g 255712948 8294976 70793..73255 1 NC_013080.1 weakly similar to uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p; KLTH0D00748p 73255 8294976 KLTH0D00748g Lachancea thermotolerans CBS 6340 KLTH0D00748p XP_002552756.1 70793 D 559295 CDS KLTH0D00770g 255712950 8294977 74519..76360 1 NC_013080.1 similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); KLTH0D00770p 76360 8294977 KLTH0D00770g Lachancea thermotolerans CBS 6340 KLTH0D00770p XP_002552757.1 74519 D 559295 CDS KLTH0D00792g 255712952 8294978 76844..77281 1 NC_013080.1 highly similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C; KLTH0D00792p 77281 8294978 KLTH0D00792g Lachancea thermotolerans CBS 6340 KLTH0D00792p XP_002552758.1 76844 D 559295 CDS KLTH0D00814g 255712954 8294979 complement(77439..78620) 1 NC_013080.1 similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; KLTH0D00814p 78620 8294979 KLTH0D00814g Lachancea thermotolerans CBS 6340 KLTH0D00814p XP_002552759.1 77439 R 559295 CDS KLTH0D00836g 255712956 8294980 complement(79191..79817) 1 NC_013080.1 similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W; KLTH0D00836p 79817 8294980 KLTH0D00836g Lachancea thermotolerans CBS 6340 KLTH0D00836p XP_002552760.1 79191 R 559295 CDS KLTH0D00858g 255712958 8294981 80807..83134 1 NC_013080.1 similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0D00858p 83134 8294981 KLTH0D00858g Lachancea thermotolerans CBS 6340 KLTH0D00858p XP_002552761.1 80807 D 559295 CDS KLTH0D00880g 255712960 8294982 complement(84021..86015) 1 NC_013080.1 highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail- anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death; KLTH0D00880p 86015 8294982 KLTH0D00880g Lachancea thermotolerans CBS 6340 KLTH0D00880p XP_002552762.1 84021 R 559295 CDS KLTH0D00902g 255712962 8294983 join(86268..86270,86342..87172) 1 NC_013080.1 highly similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit; KLTH0D00902p 87172 8294983 KLTH0D00902g Lachancea thermotolerans CBS 6340 KLTH0D00902p XP_002552763.1 86268 D 559295 CDS KLTH0D00924g 255712964 8294984 complement(87310..89439) 1 NC_013080.1 weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization; KLTH0D00924p 89439 8294984 KLTH0D00924g Lachancea thermotolerans CBS 6340 KLTH0D00924p XP_002552764.1 87310 R 559295 CDS KLTH0D00946g 255712966 8294985 89863..92082 1 NC_013080.1 similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; KLTH0D00946p 92082 8294985 KLTH0D00946g Lachancea thermotolerans CBS 6340 KLTH0D00946p XP_002552765.1 89863 D 559295 CDS KLTH0D00968g 255712968 8294986 complement(92187..92450) 1 NC_013080.1 highly similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C Hypothetical ORF; KLTH0D00968p 92450 8294986 KLTH0D00968g Lachancea thermotolerans CBS 6340 KLTH0D00968p XP_002552766.1 92187 R 559295 CDS KLTH0D00990g 255712970 8294987 92563..92928 1 NC_013080.1 similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein; KLTH0D00990p 92928 8294987 KLTH0D00990g Lachancea thermotolerans CBS 6340 KLTH0D00990p XP_002552767.1 92563 D 559295 CDS KLTH0D01012g 255712972 8294988 complement(93016..93540) 1 NC_013080.1 similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm; KLTH0D01012p 93540 8294988 KLTH0D01012g Lachancea thermotolerans CBS 6340 KLTH0D01012p XP_002552768.1 93016 R 559295 CDS KLTH0D01034g 255712974 8294989 94778..96259 1 NC_013080.1 similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon; KLTH0D01034p 96259 8294989 KLTH0D01034g Lachancea thermotolerans CBS 6340 KLTH0D01034p XP_002552769.1 94778 D 559295 CDS KLTH0D01056g 255712976 8294990 complement(97316..98434) 1 NC_013080.1 some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1; KLTH0D01056p 98434 8294990 KLTH0D01056g Lachancea thermotolerans CBS 6340 KLTH0D01056p XP_002552770.1 97316 R 559295 CDS KLTH0D01078g 255712978 8294991 complement(99148..101307) 1 NC_013080.1 similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII; KLTH0D01078p 101307 8294991 KLTH0D01078g Lachancea thermotolerans CBS 6340 KLTH0D01078p XP_002552771.1 99148 R 559295 CDS KLTH0D01100g 255712980 8294992 complement(102765..103181) 1 NC_013080.1 similar to uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated glucose- repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex; KLTH0D01100p 103181 8294992 KLTH0D01100g Lachancea thermotolerans CBS 6340 KLTH0D01100p XP_002552772.1 102765 R 559295 CDS KLTH0D01122g 255712982 8294993 103352..103834 1 NC_013080.1 similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C; KLTH0D01122p 103834 8294993 KLTH0D01122g Lachancea thermotolerans CBS 6340 KLTH0D01122p XP_002552773.1 103352 D 559295 CDS KLTH0D01144g 255712984 8294994 104099..105307 1 NC_013080.1 similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport; KLTH0D01144p 105307 8294994 KLTH0D01144g Lachancea thermotolerans CBS 6340 KLTH0D01144p XP_002552774.1 104099 D 559295 CDS KLTH0D01166g 255712986 8294995 105674..107905 1 NC_013080.1 some similarities with uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing; KLTH0D01166p 107905 8294995 KLTH0D01166g Lachancea thermotolerans CBS 6340 KLTH0D01166p XP_002552775.1 105674 D 559295 CDS KLTH0D01188g 255712988 8294996 complement(108037..109977) 1 NC_013080.1 similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF; KLTH0D01188p 109977 8294996 KLTH0D01188g Lachancea thermotolerans CBS 6340 KLTH0D01188p XP_002552776.1 108037 R 559295 CDS KLTH0D01210g 255712990 8294997 complement(110551..111846) 1 NC_013080.1 similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source; KLTH0D01210p 111846 8294997 KLTH0D01210g Lachancea thermotolerans CBS 6340 KLTH0D01210p XP_002552777.1 110551 R 559295 CDS KLTH0D01232g 255712992 8294998 complement(112790..114400) 1 NC_013080.1 conserved hypothetical protein; KLTH0D01232p 114400 8294998 KLTH0D01232g Lachancea thermotolerans CBS 6340 KLTH0D01232p XP_002552778.1 112790 R 559295 CDS KLTH0D01254g 255712994 8294999 complement(115317..116630) 1 NC_013080.1 weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin; KLTH0D01254p 116630 8294999 KLTH0D01254g Lachancea thermotolerans CBS 6340 KLTH0D01254p XP_002552779.1 115317 R 559295 CDS KLTH0D01298g 255712996 8295000 122364..124418 1 NC_013080.1 weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids; KLTH0D01298p 124418 8295000 KLTH0D01298g Lachancea thermotolerans CBS 6340 KLTH0D01298p XP_002552780.1 122364 D 559295 CDS KLTH0D01320g 255712998 8295001 complement(join(124574..125362,125428..125463)) 1 NC_013080.1 similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS); KLTH0D01320p 125463 8295001 KLTH0D01320g Lachancea thermotolerans CBS 6340 KLTH0D01320p XP_002552781.1 124574 R 559295 CDS KLTH0D01342g 255713000 8295002 126137..128377 1 NC_013080.1 similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability; KLTH0D01342p 128377 8295002 KLTH0D01342g Lachancea thermotolerans CBS 6340 KLTH0D01342p XP_002552782.1 126137 D 559295 CDS KLTH0D01364g 255713002 8295003 complement(128407..129288) 1 NC_013080.1 similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF; KLTH0D01364p 129288 8295003 KLTH0D01364g Lachancea thermotolerans CBS 6340 KLTH0D01364p XP_002552783.1 128407 R 559295 CDS KLTH0D01386g 255713004 8295004 join(129448..130053,130132..130974) 1 NC_013080.1 similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase functions in meiotic checkpoint phosphorylates Red1p interacts with Hop1p required for meiotic recombination and normal spore viability; KLTH0D01386p 130974 8295004 KLTH0D01386g Lachancea thermotolerans CBS 6340 KLTH0D01386p XP_002552784.1 129448 D 559295 CDS KLTH0D01408g 255713006 8295005 131435..133357 1 NC_013080.1 weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C; KLTH0D01408p 133357 8295005 KLTH0D01408g Lachancea thermotolerans CBS 6340 KLTH0D01408p XP_002552785.1 131435 D 559295 CDS KLTH0D01430g 255713008 8295006 complement(133354..136428) 1 NC_013080.1 weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl; KLTH0D01430p 136428 8295006 KLTH0D01430g Lachancea thermotolerans CBS 6340 KLTH0D01430p XP_002552786.1 133354 R 559295 CDS KLTH0D01452g 255713010 8295007 complement(136785..138086) 1 NC_013080.1 conserved hypothetical protein; KLTH0D01452p 138086 8295007 KLTH0D01452g Lachancea thermotolerans CBS 6340 KLTH0D01452p XP_002552787.1 136785 R 559295 CDS KLTH0D01474g 255713012 8295008 139116..140990 1 NC_013080.1 similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline- specific permease; KLTH0D01474p 140990 8295008 KLTH0D01474g Lachancea thermotolerans CBS 6340 KLTH0D01474p XP_002552788.1 139116 D 559295 CDS KLTH0D01496g 255713014 8295009 142438..143943 1 NC_013080.1 highly similar to uniprot|P00549 Saccharomyces cerevisiae YAL038W CDC19 Pyruvate kinase functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; KLTH0D01496p 143943 8295009 KLTH0D01496g Lachancea thermotolerans CBS 6340 KLTH0D01496p XP_002552789.1 142438 D 559295 CDS KLTH0D01518g 255713016 8295010 complement(144017..147001) 1 NC_013080.1 similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA; KLTH0D01518p 147001 8295010 KLTH0D01518g Lachancea thermotolerans CBS 6340 KLTH0D01518p XP_002552790.1 144017 R 559295 CDS KLTH0D01540g 255713018 8295011 148109..149155 1 NC_013080.1 some similarities with uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix- loop- helix/leucine-zipper protein family; KLTH0D01540p 149155 8295011 KLTH0D01540g Lachancea thermotolerans CBS 6340 KLTH0D01540p XP_002552791.1 148109 D 559295 CDS KLTH0D01562g 255713020 8295012 151489..152424 1 NC_013080.1 weakly similar to uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF; KLTH0D01562p 152424 8295012 KLTH0D01562g Lachancea thermotolerans CBS 6340 KLTH0D01562p XP_002552792.1 151489 D 559295 CDS KLTH0D01584g 255713022 8295013 complement(152846..153952) 1 NC_013080.1 highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins; KLTH0D01584p 153952 8295013 KLTH0D01584g Lachancea thermotolerans CBS 6340 KLTH0D01584p XP_002552793.1 152846 R 559295 CDS KLTH0D01606g 255713024 8295014 154310..157306 1 NC_013080.1 similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2; KLTH0D01606p 157306 8295014 KLTH0D01606g Lachancea thermotolerans CBS 6340 KLTH0D01606p XP_002552794.1 154310 D 559295 CDS KLTH0D01628g 255713026 8295015 complement(157597..162561) 1 NC_013080.1 highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I; KLTH0D01628p 162561 8295015 KLTH0D01628g Lachancea thermotolerans CBS 6340 KLTH0D01628p XP_002552795.1 157597 R 559295 CDS KLTH0D01650g 255713028 8295016 162973..163164 1 NC_013080.1 conserved hypothetical protein; KLTH0D01650p 163164 8295016 KLTH0D01650g Lachancea thermotolerans CBS 6340 KLTH0D01650p XP_002552796.1 162973 D 559295 CDS KLTH0D01694g 255713030 8295017 166143..168788 1 NC_013080.1 conserved hypothetical protein; KLTH0D01694p 168788 8295017 KLTH0D01694g Lachancea thermotolerans CBS 6340 KLTH0D01694p XP_002552797.1 166143 D 559295 CDS KLTH0D01716g 255713032 8295018 169128..170021 1 NC_013080.1 similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43; KLTH0D01716p 170021 8295018 KLTH0D01716g Lachancea thermotolerans CBS 6340 KLTH0D01716p XP_002552798.1 169128 D 559295 CDS KLTH0D01738g 255713034 8295019 170277..171152 1 NC_013080.1 similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly; KLTH0D01738p 171152 8295019 KLTH0D01738g Lachancea thermotolerans CBS 6340 KLTH0D01738p XP_002552799.1 170277 D 559295 CDS KLTH0D01760g 255713036 8295020 171356..171841 1 NC_013080.1 highly similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C; KLTH0D01760p 171841 8295020 KLTH0D01760g Lachancea thermotolerans CBS 6340 KLTH0D01760p XP_002552800.1 171356 D 559295 CDS KLTH0D01782g 255713038 8295021 complement(172172..173227) 1 NC_013080.1 similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF; KLTH0D01782p 173227 8295021 KLTH0D01782g Lachancea thermotolerans CBS 6340 KLTH0D01782p XP_002552801.1 172172 R 559295 CDS KLTH0D01804g 255713040 8295022 complement(173650..175608) 1 NC_013080.1 KLTH0D01804p 175608 8295022 KLTH0D01804g Lachancea thermotolerans CBS 6340 KLTH0D01804p XP_002552802.1 173650 R 559295 CDS KLTH0D01826g 255713042 8295023 complement(175846..179820) 1 NC_013080.1 similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects; KLTH0D01826p 179820 8295023 KLTH0D01826g Lachancea thermotolerans CBS 6340 KLTH0D01826p XP_002552803.1 175846 R 559295 CDS KLTH0D01848g 255713044 8295024 180421..183288 1 NC_013080.1 highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog; KLTH0D01848p 183288 8295024 KLTH0D01848g Lachancea thermotolerans CBS 6340 KLTH0D01848p XP_002552804.1 180421 D 559295 CDS KLTH0D01870g 255713046 8295025 184749..185243 1 NC_013080.1 similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; KLTH0D01870p 185243 8295025 KLTH0D01870g Lachancea thermotolerans CBS 6340 KLTH0D01870p XP_002552805.1 184749 D 559295 CDS KLTH0D01892g 255713048 8295026 complement(185319..186674) 1 NC_013080.1 similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p; KLTH0D01892p 186674 8295026 KLTH0D01892g Lachancea thermotolerans CBS 6340 KLTH0D01892p XP_002552806.1 185319 R 559295 CDS KLTH0D01914g 255713050 8295027 complement(186816..189233) 1 NC_013080.1 some similarities with uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate; KLTH0D01914p 189233 8295027 KLTH0D01914g Lachancea thermotolerans CBS 6340 KLTH0D01914p XP_002552807.1 186816 R 559295 CDS KLTH0D01936g 255713052 8295028 complement(189479..190762) 1 NC_013080.1 similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2 ) channel required for maintenance of intramitochondrial Mg(2 ) concentrations at the correct level to support splicing of group II introns; KLTH0D01936p 190762 8295028 KLTH0D01936g Lachancea thermotolerans CBS 6340 KLTH0D01936p XP_002552808.1 189479 R 559295 CDS KLTH0D01958g 255713054 8295029 complement(191031..191723) 1 NC_013080.1 similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa); KLTH0D01958p 191723 8295029 KLTH0D01958g Lachancea thermotolerans CBS 6340 KLTH0D01958p XP_002552809.1 191031 R 559295 CDS KLTH0D01980g 255713056 8295030 192827..196498 1 NC_013080.1 similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase; KLTH0D01980p 196498 8295030 KLTH0D01980g Lachancea thermotolerans CBS 6340 KLTH0D01980p XP_002552810.1 192827 D 559295 CDS KLTH0D02002g 255713058 8295031 complement(196550..197293) 1 NC_013080.1 conserved hypothetical protein; KLTH0D02002p 197293 8295031 KLTH0D02002g Lachancea thermotolerans CBS 6340 KLTH0D02002p XP_002552811.1 196550 R 559295 CDS KLTH0D02024g 255713060 8295032 197416..199332 1 NC_013080.1 some similarities with uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants; KLTH0D02024p 199332 8295032 KLTH0D02024g Lachancea thermotolerans CBS 6340 KLTH0D02024p XP_002552812.1 197416 D 559295 CDS KLTH0D02046g 255713062 8295033 join(199583..199663,199742..199990) 1 NC_013080.1 similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog; KLTH0D02046p 199990 8295033 KLTH0D02046g Lachancea thermotolerans CBS 6340 KLTH0D02046p XP_002552813.1 199583 D 559295 CDS KLTH0D02068g 255713064 8295034 complement(200288..204958) 1 NC_013080.1 similar to uniprot|P19524 Saccharomyces cerevisiae YOR326W MYO2 One of two type V myosins involved in polarized distribution of mitochondria required for mitochondrion and vacuole inheritance and nuclear spindle orientation moves multiple cargo; KLTH0D02068p 204958 8295034 KLTH0D02068g Lachancea thermotolerans CBS 6340 KLTH0D02068p XP_002552814.1 200288 R 559295 CDS KLTH0D02090g 255713066 8295035 206308..207483 1 NC_013080.1 conserved hypothetical protein; KLTH0D02090p 207483 8295035 KLTH0D02090g Lachancea thermotolerans CBS 6340 KLTH0D02090p XP_002552815.1 206308 D 559295 CDS KLTH0D02112g 255713068 8295036 join(207735..207816,207874..208643) 1 NC_013080.1 similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W Hypothetical ORF; KLTH0D02112p 208643 8295036 KLTH0D02112g Lachancea thermotolerans CBS 6340 KLTH0D02112p XP_002552816.1 207735 D 559295 CDS KLTH0D02134g 255713070 8295037 208745..210118 1 NC_013080.1 highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis; KLTH0D02134p 210118 8295037 KLTH0D02134g Lachancea thermotolerans CBS 6340 KLTH0D02134p XP_002552817.1 208745 D 559295 CDS KLTH0D02156g 255713072 8295038 complement(210244..214179) 1 NC_013080.1 highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2 )-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA; KLTH0D02156p 214179 8295038 KLTH0D02156g Lachancea thermotolerans CBS 6340 KLTH0D02156p XP_002552818.1 210244 R 559295 CDS KLTH0D02178g 255713074 8295039 complement(214421..215329) 1 NC_013080.1 some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus; KLTH0D02178p 215329 8295039 KLTH0D02178g Lachancea thermotolerans CBS 6340 KLTH0D02178p XP_002552819.1 214421 R 559295 CDS KLTH0D02200g 255713076 8295040 complement(215729..219868) 1 NC_013080.1 similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p- GTP; KLTH0D02200p 219868 8295040 KLTH0D02200g Lachancea thermotolerans CBS 6340 KLTH0D02200p XP_002552820.1 215729 R 559295 CDS KLTH0D02222g 255713078 8295041 220570..223113 1 NC_013080.1 weakly similar to uniprot|P52960 Saccharomyces cerevisiae YOR363C PIP2 peroxisome induction pathway 2 (PIP2) transcriptional activator of peroxisome proliferation may form heterodimer with Oaf1 to activate oleate-inducible gene expression activator of peroxisome proliferation; KLTH0D02222p 223113 8295041 KLTH0D02222g Lachancea thermotolerans CBS 6340 KLTH0D02222p XP_002552821.1 220570 D 559295 CDS KLTH0D02244g 255713080 8295042 223460..225718 1 NC_013080.1 similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C Hypothetical ORF; KLTH0D02244p 225718 8295042 KLTH0D02244g Lachancea thermotolerans CBS 6340 KLTH0D02244p XP_002552822.1 223460 D 559295 CDS KLTH0D02266g 255713082 8295043 complement(225886..228108) 1 NC_013080.1 highly similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D-mannose:protein O-D-mannosyltransferase; KLTH0D02266p 228108 8295043 KLTH0D02266g Lachancea thermotolerans CBS 6340 KLTH0D02266p XP_002552823.1 225886 R 559295 CDS KLTH0D02288g 255713084 8295044 complement(229079..230371) 1 NC_013080.1 similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes; KLTH0D02288p 230371 8295044 KLTH0D02288g Lachancea thermotolerans CBS 6340 KLTH0D02288p XP_002552824.1 229079 R 559295 CDS KLTH0D02310g 255713086 8295045 complement(230632..232851) 1 NC_013080.1 similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening; KLTH0D02310p 232851 8295045 KLTH0D02310g Lachancea thermotolerans CBS 6340 KLTH0D02310p XP_002552825.1 230632 R 559295 CDS KLTH0D02332g 255713088 8295046 complement(233733..234704) 1 NC_013080.1 weakly similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1; KLTH0D02332p 234704 8295046 KLTH0D02332g Lachancea thermotolerans CBS 6340 KLTH0D02332p XP_002552826.1 233733 R 559295 CDS KLTH0D02354g 255713090 8295047 235169..238312 1 NC_013080.1 some similarities with uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p; KLTH0D02354p 238312 8295047 KLTH0D02354g Lachancea thermotolerans CBS 6340 KLTH0D02354p XP_002552827.1 235169 D 559295 CDS KLTH0D02376g 255713092 8295048 238729..241989 1 NC_013080.1 some similarities with uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Component of the Mediator complex interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme affects transcription by acting as target of activators and repressors; KLTH0D02376p 241989 8295048 KLTH0D02376g Lachancea thermotolerans CBS 6340 KLTH0D02376p XP_002552828.1 238729 D 559295 CDS KLTH0D02398g 255713094 8295049 242227..243681 1 NC_013080.1 similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP- dependent synthesis of glutathione (GSH) from gamma- glutamylcysteine and glycine induced by oxidative stress and heat shock; KLTH0D02398p 243681 8295049 KLTH0D02398g Lachancea thermotolerans CBS 6340 KLTH0D02398p XP_002552829.1 242227 D 559295 CDS KLTH0D02420g 255713096 8295050 complement(join(243691..244410,244482..244697)) 1 NC_013080.1 similar to uniprot|Q870H5 Saccharomyces cerevisiae YOL048C Hypothetical ORF; KLTH0D02420p 244697 8295050 KLTH0D02420g Lachancea thermotolerans CBS 6340 KLTH0D02420p XP_002552830.1 243691 R 559295 CDS KLTH0D02442g 255713098 8295051 complement(244834..245499) 1 NC_013080.1 some similarities with uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF; KLTH0D02442p 245499 8295051 KLTH0D02442g Lachancea thermotolerans CBS 6340 KLTH0D02442p XP_002552831.1 244834 R 559295 CDS KLTH0D02464g 255713100 8295052 complement(join(246019..246765,246832..247056)) 1 NC_013080.1 similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF; KLTH0D02464p 247056 8295052 KLTH0D02464g Lachancea thermotolerans CBS 6340 KLTH0D02464p XP_002552832.1 246019 R 559295 CDS KLTH0D02486g 255713102 8295053 247566..251237 1 NC_013080.1 similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; KLTH0D02486p 251237 8295053 KLTH0D02486g Lachancea thermotolerans CBS 6340 KLTH0D02486p XP_002552833.1 247566 D 559295 CDS KLTH0D02508g 255713104 8295054 252131..253195 1 NC_013080.1 some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail- anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol overexpression results in impaired peroxisome assembly; KLTH0D02508p 253195 8295054 KLTH0D02508g Lachancea thermotolerans CBS 6340 KLTH0D02508p XP_002552834.1 252131 D 559295 CDS KLTH0D02530g 255713106 8295055 253509..255377 1 NC_013080.1 highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A; KLTH0D02530p 255377 8295055 KLTH0D02530g Lachancea thermotolerans CBS 6340 KLTH0D02530p XP_002552835.1 253509 D 559295 CDS KLTH0D02552g 255713108 8295056 complement(255490..256641) 1 NC_013080.1 similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; KLTH0D02552p 256641 8295056 KLTH0D02552g Lachancea thermotolerans CBS 6340 KLTH0D02552p XP_002552836.1 255490 R 559295 CDS KLTH0D02574g 255713110 8295057 257847..258953 1 NC_013080.1 similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W; KLTH0D02574p 258953 8295057 KLTH0D02574g Lachancea thermotolerans CBS 6340 KLTH0D02574p XP_002552837.1 257847 D 559295 CDS KLTH0D02596g 255713112 8295058 259063..259707 1 NC_013080.1 conserved hypothetical protein; KLTH0D02596p 259707 8295058 KLTH0D02596g Lachancea thermotolerans CBS 6340 KLTH0D02596p XP_002552838.1 259063 D 559295 CDS KLTH0D02618g 255713114 8295059 complement(260346..261161) 1 NC_013080.1 similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8; KLTH0D02618p 261161 8295059 KLTH0D02618g Lachancea thermotolerans CBS 6340 KLTH0D02618p XP_002552839.1 260346 R 559295 CDS KLTH0D02640g 255713116 8295060 complement(261313..262701) 1 NC_013080.1 similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C; KLTH0D02640p 262701 8295060 KLTH0D02640g Lachancea thermotolerans CBS 6340 KLTH0D02640p XP_002552840.1 261313 R 559295 CDS KLTH0D02662g 255713118 8295061 263089..265008 1 NC_013080.1 some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation; KLTH0D02662p 265008 8295061 KLTH0D02662g Lachancea thermotolerans CBS 6340 KLTH0D02662p XP_002552841.1 263089 D 559295 CDS KLTH0D02684g 255713120 8295062 complement(265105..265533) 1 NC_013080.1 highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C; KLTH0D02684p 265533 8295062 KLTH0D02684g Lachancea thermotolerans CBS 6340 KLTH0D02684p XP_002552842.1 265105 R 559295 CDS KLTH0D02706g 255713122 8295063 266107..266430 1 NC_013080.1 similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; KLTH0D02706p 266430 8295063 KLTH0D02706g Lachancea thermotolerans CBS 6340 KLTH0D02706p XP_002552843.1 266107 D 559295 CDS KLTH0D02728g 255713124 8295064 267019..268197 1 NC_013080.1 highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; KLTH0D02728p 268197 8295064 KLTH0D02728g Lachancea thermotolerans CBS 6340 KLTH0D02728p XP_002552844.1 267019 D 559295 CDS KLTH0D02750g 255713126 8295065 268438..269559 1 NC_013080.1 similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER; KLTH0D02750p 269559 8295065 KLTH0D02750g Lachancea thermotolerans CBS 6340 KLTH0D02750p XP_002552845.1 268438 D 559295 CDS KLTH0D02772g 255713128 8295066 complement(269632..270336) 1 NC_013080.1 similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF; KLTH0D02772p 270336 8295066 KLTH0D02772g Lachancea thermotolerans CBS 6340 KLTH0D02772p XP_002552846.1 269632 R 559295 CDS KLTH0D02794g 255713130 8295067 complement(270516..272156) 1 NC_013080.1 similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene; KLTH0D02794p 272156 8295067 KLTH0D02794g Lachancea thermotolerans CBS 6340 KLTH0D02794p XP_002552847.1 270516 R 559295 CDS KLTH0D02816g 255713132 8295068 complement(272310..275594) 1 NC_013080.1 similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein interacts with Rhc18p and Nse1p to form a large complex S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair; KLTH0D02816p 275594 8295068 KLTH0D02816g Lachancea thermotolerans CBS 6340 KLTH0D02816p XP_002552848.1 272310 R 559295 CDS KLTH0D02838g 255713134 8295069 275812..277566 1 NC_013080.1 weakly similar to uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for formation of nuclear- associated array of smooth endoplasmic reticulum known as karmellae; KLTH0D02838p 277566 8295069 KLTH0D02838g Lachancea thermotolerans CBS 6340 KLTH0D02838p XP_002552849.1 275812 D 559295 CDS KLTH0D02860g 255713136 8295070 complement(277582..278958) 1 NC_013080.1 similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance; KLTH0D02860p 278958 8295070 KLTH0D02860g Lachancea thermotolerans CBS 6340 KLTH0D02860p XP_002552850.1 277582 R 559295 CDS KLTH0D02882g 255713138 8295071 279103..280044 1 NC_013080.1 similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation; KLTH0D02882p 280044 8295071 KLTH0D02882g Lachancea thermotolerans CBS 6340 KLTH0D02882p XP_002552851.1 279103 D 559295 CDS KLTH0D02904g 255713140 8295072 join(280411..280434,280502..282445) 1 NC_013080.1 similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A); KLTH0D02904p 282445 8295072 KLTH0D02904g Lachancea thermotolerans CBS 6340 KLTH0D02904p XP_002552852.1 280411 D 559295 CDS KLTH0D02926g 255713142 8295073 282956..283561 1 NC_013080.1 conserved hypothetical protein; KLTH0D02926p 283561 8295073 KLTH0D02926g Lachancea thermotolerans CBS 6340 KLTH0D02926p XP_002552853.1 282956 D 559295 CDS KLTH0D02948g 255713144 8295074 283762..284394 1 NC_013080.1 highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor contains five zinc fingers required for pre-mRNA 3'-end processing and polyadenylation; KLTH0D02948p 284394 8295074 KLTH0D02948g Lachancea thermotolerans CBS 6340 KLTH0D02948p XP_002552854.1 283762 D 559295 CDS KLTH0D02970g 255713146 8295075 complement(284533..285945) 1 NC_013080.1 weakly similar to uniprot|Q06098 Saccharomyces cerevisiae YPR106W ISR1 Predicted protein kinase overexpression causes sensitivity to staurosporine which is a potent inhibitor of protein kinase C; KLTH0D02970p 285945 8295075 KLTH0D02970g Lachancea thermotolerans CBS 6340 KLTH0D02970p XP_002552855.1 284533 R 559295 CDS KLTH0D02992g 255713148 8295076 286526..287836 1 NC_013080.1 highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p; KLTH0D02992p 287836 8295076 KLTH0D02992g Lachancea thermotolerans CBS 6340 KLTH0D02992p XP_002552856.1 286526 D 559295 CDS KLTH0D03014g 255713150 8295077 288113..290551 1 NC_013080.1 similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex; KLTH0D03014p 290551 8295077 KLTH0D03014g Lachancea thermotolerans CBS 6340 KLTH0D03014p XP_002552857.1 288113 D 559295 CDS KLTH0D03036g 255713152 8295078 290948..293524 1 NC_013080.1 similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C; KLTH0D03036p 293524 8295078 KLTH0D03036g Lachancea thermotolerans CBS 6340 KLTH0D03036p XP_002552858.1 290948 D 559295 CDS KLTH0D03058g 255713154 8295079 complement(293867..294730) 1 NC_013080.1 highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit; KLTH0D03058p 294730 8295079 KLTH0D03058g Lachancea thermotolerans CBS 6340 KLTH0D03058p XP_002552859.1 293867 R 559295 CDS KLTH0D03080g 255713156 8295080 295808..297730 1 NC_013080.1 similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p; KLTH0D03080p 297730 8295080 KLTH0D03080g Lachancea thermotolerans CBS 6340 KLTH0D03080p XP_002552860.1 295808 D 559295 CDS KLTH0D03102g 255713158 8295081 299166..301421 1 NC_013080.1 similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3; KLTH0D03102p 301421 8295081 KLTH0D03102g Lachancea thermotolerans CBS 6340 KLTH0D03102p XP_002552861.1 299166 D 559295 CDS KLTH0D03124g 255713160 8295082 301688..302095 1 NC_013080.1 similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W; KLTH0D03124p 302095 8295082 KLTH0D03124g Lachancea thermotolerans CBS 6340 KLTH0D03124p XP_002552862.1 301688 D 559295 CDS KLTH0D03146g 255713162 8295083 complement(302961..304298) 1 NC_013080.1 conserved hypothetical protein; KLTH0D03146p 304298 8295083 KLTH0D03146g Lachancea thermotolerans CBS 6340 KLTH0D03146p XP_002552863.1 302961 R 559295 CDS KLTH0D03168g 255713164 8295084 304459..306024 1 NC_013080.1 similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF; KLTH0D03168p 306024 8295084 KLTH0D03168g Lachancea thermotolerans CBS 6340 KLTH0D03168p XP_002552864.1 304459 D 559295 CDS KLTH0D03190g 255713166 8295085 complement(306459..308609) 1 NC_013080.1 similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; KLTH0D03190p 308609 8295085 KLTH0D03190g Lachancea thermotolerans CBS 6340 KLTH0D03190p XP_002552865.1 306459 R 559295 CDS KLTH0D03212g 255713168 8295086 308786..309532 1 NC_013080.1 similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37; KLTH0D03212p 309532 8295086 KLTH0D03212g Lachancea thermotolerans CBS 6340 KLTH0D03212p XP_002552866.1 308786 D 559295 CDS KLTH0D03234g 255713170 8295087 complement(309575..310492) 1 NC_013080.1 highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a positive regulator of GCN4 expression; KLTH0D03234p 310492 8295087 KLTH0D03234g Lachancea thermotolerans CBS 6340 KLTH0D03234p XP_002552867.1 309575 R 559295 CDS KLTH0D03256g 255713172 8295088 310691..313087 1 NC_013080.1 similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G- like protein; KLTH0D03256p 313087 8295088 KLTH0D03256g Lachancea thermotolerans CBS 6340 KLTH0D03256p XP_002552868.1 310691 D 559295 CDS KLTH0D03322g 255713174 8295091 complement(314732..316684) 1 NC_013080.1 similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury; KLTH0D03322p 316684 8295091 KLTH0D03322g Lachancea thermotolerans CBS 6340 KLTH0D03322p XP_002552869.1 314732 R 559295 CDS KLTH0D03344g 255713176 8295092 317628..319313 1 NC_013080.1 similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; KLTH0D03344p 319313 8295092 KLTH0D03344g Lachancea thermotolerans CBS 6340 KLTH0D03344p XP_002552870.1 317628 D 559295 CDS KLTH0D03366g 255713178 8295093 319479..321656 1 NC_013080.1 similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein; KLTH0D03366p 321656 8295093 KLTH0D03366g Lachancea thermotolerans CBS 6340 KLTH0D03366p XP_002552871.1 319479 D 559295 CDS KLTH0D03388g 255713180 8295094 322117..325185 1 NC_013080.1 similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W; KLTH0D03388p 325185 8295094 KLTH0D03388g Lachancea thermotolerans CBS 6340 KLTH0D03388p XP_002552872.1 322117 D 559295 CDS KLTH0D03410g 255713182 8295095 325452..326096 1 NC_013080.1 similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability; KLTH0D03410p 326096 8295095 KLTH0D03410g Lachancea thermotolerans CBS 6340 KLTH0D03410p XP_002552873.1 325452 D 559295 CDS KLTH0D03432g 255713184 8295096 326296..326769 1 NC_013080.1 some similarities with uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit; KLTH0D03432p 326769 8295096 KLTH0D03432g Lachancea thermotolerans CBS 6340 KLTH0D03432p XP_002552874.1 326296 D 559295 CDS KLTH0D03454g 255713186 8295097 327039..331340 1 NC_013080.1 similar to uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway which controls cell integrity upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; KLTH0D03454p 331340 8295097 KLTH0D03454g Lachancea thermotolerans CBS 6340 KLTH0D03454p XP_002552875.1 327039 D 559295 CDS KLTH0D03476g 255713188 8295098 complement(333077..334864) 1 NC_013080.1 similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward- rectifier potassium channel; KLTH0D03476p 334864 8295098 KLTH0D03476g Lachancea thermotolerans CBS 6340 KLTH0D03476p XP_002552876.1 333077 R 559295 CDS KLTH0D03498g 255713190 8295099 335566..338838 1 NC_013080.1 weakly similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate; KLTH0D03498p 338838 8295099 KLTH0D03498g Lachancea thermotolerans CBS 6340 KLTH0D03498p XP_002552877.1 335566 D 559295 CDS KLTH0D03520g 255713192 8295100 complement(338875..340320) 1 NC_013080.1 similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; KLTH0D03520p 340320 8295100 KLTH0D03520g Lachancea thermotolerans CBS 6340 KLTH0D03520p XP_002552878.1 338875 R 559295 CDS KLTH0D03542g 255713194 8295101 complement(340512..342635) 1 NC_013080.1 similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control; KLTH0D03542p 342635 8295101 KLTH0D03542g Lachancea thermotolerans CBS 6340 KLTH0D03542p XP_002552879.1 340512 R 559295 CDS KLTH0D03564g 255713196 8295102 343546..346134 1 NC_013080.1 weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 Possibly involved in Snf1p regulated transcriptional activation shows homology to DNA binding domain of Gal4p has a leucine zipper motif and acidic region lexA-Sip4p activates transcription; KLTH0D03564p 346134 8295102 KLTH0D03564g Lachancea thermotolerans CBS 6340 KLTH0D03564p XP_002552880.1 343546 D 559295 CDS KLTH0D03586g 255713198 8295103 346309..347241 1 NC_013080.1 weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability; KLTH0D03586p 347241 8295103 KLTH0D03586g Lachancea thermotolerans CBS 6340 KLTH0D03586p XP_002552881.1 346309 D 559295 CDS KLTH0D03608g 255713200 8295104 join(349672..349685,349747..355387) 1 NC_013080.1 similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; KLTH0D03608p 355387 8295104 KLTH0D03608g Lachancea thermotolerans CBS 6340 KLTH0D03608p XP_002552882.1 349672 D 559295 CDS KLTH0D03630g 255713202 8295105 355806..358145 1 NC_013080.1 highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy; KLTH0D03630p 358145 8295105 KLTH0D03630g Lachancea thermotolerans CBS 6340 KLTH0D03630p XP_002552883.1 355806 D 559295 CDS KLTH0D03652g 255713204 8295106 complement(358612..359946) 1 NC_013080.1 highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis; KLTH0D03652p 359946 8295106 KLTH0D03652g Lachancea thermotolerans CBS 6340 KLTH0D03652p XP_002552884.1 358612 R 559295 CDS KLTH0D03718g 255713206 8295109 complement(362790..364790) 1 NC_013080.1 conserved hypothetical protein; KLTH0D03718p 364790 8295109 KLTH0D03718g Lachancea thermotolerans CBS 6340 KLTH0D03718p XP_002552885.1 362790 R 559295 CDS KLTH0D03740g 255713208 8295110 complement(join(365191..366136,366198..366253)) 1 NC_013080.1 similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins; KLTH0D03740p 366253 8295110 KLTH0D03740g Lachancea thermotolerans CBS 6340 KLTH0D03740p XP_002552886.1 365191 R 559295 CDS KLTH0D03762g 255713210 8295111 366599..367396 1 NC_013080.1 similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W Hypothetical ORF; KLTH0D03762p 367396 8295111 KLTH0D03762g Lachancea thermotolerans CBS 6340 KLTH0D03762p XP_002552887.1 366599 D 559295 CDS KLTH0D03784g 255713212 8295112 complement(367647..370937) 1 NC_013080.1 some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220; KLTH0D03784p 370937 8295112 KLTH0D03784g Lachancea thermotolerans CBS 6340 KLTH0D03784p XP_002552888.1 367647 R 559295 CDS KLTH0D03806g 255713214 8295113 complement(371457..372674) 1 NC_013080.1 highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates bound by ubiquitin- protein ligases Ubr1p and Ufd4p localized mainly to the nucleus throughout the cell cycle; KLTH0D03806p 372674 8295113 KLTH0D03806g Lachancea thermotolerans CBS 6340 KLTH0D03806p XP_002552889.1 371457 R 559295 CDS KLTH0D03828g 255713216 8295114 372909..373505 1 NC_013080.1 similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W; KLTH0D03828p 373505 8295114 KLTH0D03828g Lachancea thermotolerans CBS 6340 KLTH0D03828p XP_002552890.1 372909 D 559295 CDS KLTH0D03872g 255713218 8295116 374437..375381 1 NC_013080.1 some similarities with YGR161c, uniprot|P53289 Saccharomyces cerevisiae Hypothetical ORF, RTS3 SGDID:S0003393; KLTH0D03872p 375381 8295116 KLTH0D03872g Lachancea thermotolerans CBS 6340 KLTH0D03872p XP_002552891.1 374437 D 559295 CDS KLTH0D03894g 255713220 8295117 376254..378374 1 NC_013080.1 some similarities with uniprot|P08068 Saccharomyces cerevisiae YIR019C GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth; KLTH0D03894p 378374 8295117 KLTH0D03894g Lachancea thermotolerans CBS 6340 KLTH0D03894p XP_002552892.1 376254 D 559295 CDS KLTH0D03916g 255713222 8295118 378839..380356 1 NC_013080.1 some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre- rRNA processing and ribosome biogenesis; KLTH0D03916p 380356 8295118 KLTH0D03916g Lachancea thermotolerans CBS 6340 KLTH0D03916p XP_002552893.1 378839 D 559295 CDS KLTH0D03938g 255713224 8295119 380728..382380 1 NC_013080.1 similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8; KLTH0D03938p 382380 8295119 KLTH0D03938g Lachancea thermotolerans CBS 6340 KLTH0D03938p XP_002552894.1 380728 D 559295 CDS KLTH0D03960g 255713226 8295120 382557..383288 1 NC_013080.1 similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH; KLTH0D03960p 383288 8295120 KLTH0D03960g Lachancea thermotolerans CBS 6340 KLTH0D03960p XP_002552895.1 382557 D 559295 CDS KLTH0D03982g 255713228 8295121 complement(383372..385900) 1 NC_013080.1 similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl- ethanolamine N-methyltransferase; KLTH0D03982p 385900 8295121 KLTH0D03982g Lachancea thermotolerans CBS 6340 KLTH0D03982p XP_002552896.1 383372 R 559295 CDS KLTH0D04004g 255713230 8295122 complement(386364..387077) 1 NC_013080.1 conserved hypothetical protein; KLTH0D04004p 387077 8295122 KLTH0D04004g Lachancea thermotolerans CBS 6340 KLTH0D04004p XP_002552897.1 386364 R 559295 CDS KLTH0D04026g 255713232 8295123 387535..388557 1 NC_013080.1 highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta- aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus; KLTH0D04026p 388557 8295123 KLTH0D04026g Lachancea thermotolerans CBS 6340 KLTH0D04026p XP_002552898.1 387535 D 559295 CDS KLTH0D04048g 255713234 8295124 complement(388657..389301) 1 NC_013080.1 similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative); KLTH0D04048p 389301 8295124 KLTH0D04048g Lachancea thermotolerans CBS 6340 KLTH0D04048p XP_002552899.1 388657 R 559295 CDS KLTH0D04070g 255713236 8295125 389632..390534 1 NC_013080.1 conserved hypothetical protein; KLTH0D04070p 390534 8295125 KLTH0D04070g Lachancea thermotolerans CBS 6340 KLTH0D04070p XP_002552900.1 389632 D 559295 CDS KLTH0D04092g 255713238 8295126 391381..392862 1 NC_013080.1 highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis; KLTH0D04092p 392862 8295126 KLTH0D04092g Lachancea thermotolerans CBS 6340 KLTH0D04092p XP_002552901.1 391381 D 559295 CDS KLTH0D04114g 255713240 8295127 complement(392935..393360) 1 NC_013080.1 similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry; KLTH0D04114p 393360 8295127 KLTH0D04114g Lachancea thermotolerans CBS 6340 KLTH0D04114p XP_002552902.1 392935 R 559295 CDS KLTH0D04136g 255713242 8295128 complement(393617..394498) 1 NC_013080.1 similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS; KLTH0D04136p 394498 8295128 KLTH0D04136g Lachancea thermotolerans CBS 6340 KLTH0D04136p XP_002552903.1 393617 R 559295 CDS KLTH0D04158g 255713244 8295129 394755..395537 1 NC_013080.1 similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; KLTH0D04158p 395537 8295129 KLTH0D04158g Lachancea thermotolerans CBS 6340 KLTH0D04158p XP_002552904.1 394755 D 559295 CDS KLTH0D04180g 255713246 8295130 395761..396993 1 NC_013080.1 weakly similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein; KLTH0D04180p 396993 8295130 KLTH0D04180g Lachancea thermotolerans CBS 6340 KLTH0D04180p XP_002552905.1 395761 D 559295 CDS KLTH0D04224g 255713248 8295132 397596..398858 1 NC_013080.1 similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate- grown cells; KLTH0D04224p 398858 8295132 KLTH0D04224g Lachancea thermotolerans CBS 6340 KLTH0D04224p XP_002552906.1 397596 D 559295 CDS KLTH0D04246g 255713250 8295133 399391..400305 1 NC_013080.1 similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport; KLTH0D04246p 400305 8295133 KLTH0D04246g Lachancea thermotolerans CBS 6340 KLTH0D04246p XP_002552907.1 399391 D 559295 CDS KLTH0D04268g 255713252 8295134 complement(400463..401158) 1 NC_013080.1 some similarities with uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression; KLTH0D04268p 401158 8295134 KLTH0D04268g Lachancea thermotolerans CBS 6340 KLTH0D04268p XP_002552908.1 400463 R 559295 CDS KLTH0D04290g 255713254 8295135 402264..402911 1 NC_013080.1 conserved hypothetical protein; KLTH0D04290p 402911 8295135 KLTH0D04290g Lachancea thermotolerans CBS 6340 KLTH0D04290p XP_002552909.1 402264 D 559295 CDS KLTH0D04312g 255713256 8295136 403678..404184 1 NC_013080.1 some similarities with uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF and to YKL141W uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone , member of GLR.231; KLTH0D04312p 404184 8295136 KLTH0D04312g Lachancea thermotolerans CBS 6340 KLTH0D04312p XP_002552910.1 403678 D 559295 CDS KLTH0D04334g 255713258 8295137 404397..405824 1 NC_013080.1 similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes; KLTH0D04334p 405824 8295137 KLTH0D04334g Lachancea thermotolerans CBS 6340 KLTH0D04334p XP_002552911.1 404397 D 559295 CDS KLTH0D04356g 255713260 8295138 join(405904..405987,406076..407401) 1 NC_013080.1 similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; KLTH0D04356p 407401 8295138 KLTH0D04356g Lachancea thermotolerans CBS 6340 KLTH0D04356p XP_002552912.1 405904 D 559295 CDS KLTH0D04378g 255713262 8295139 407803..408396 1 NC_013080.1 weakly similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p- Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering; KLTH0D04378p 408396 8295139 KLTH0D04378g Lachancea thermotolerans CBS 6340 KLTH0D04378p XP_002552913.1 407803 D 559295 CDS KLTH0D04400g 255713264 8295140 complement(408480..408875) 1 NC_013080.1 similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit; KLTH0D04400p 408875 8295140 KLTH0D04400g Lachancea thermotolerans CBS 6340 KLTH0D04400p XP_002552914.1 408480 R 559295 CDS KLTH0D04422g 255713266 8295141 409088..409414 1 NC_013080.1 similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF; KLTH0D04422p 409414 8295141 KLTH0D04422g Lachancea thermotolerans CBS 6340 KLTH0D04422p XP_002552915.1 409088 D 559295 CDS KLTH0D04444g 255713268 8295142 complement(409499..411616) 1 NC_013080.1 similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin- associated protein (AP-1) complex; KLTH0D04444p 411616 8295142 KLTH0D04444g Lachancea thermotolerans CBS 6340 KLTH0D04444p XP_002552916.1 409499 R 559295 CDS KLTH0D04466g 255713270 8295143 join(413024..413560,413816..414238) 1 NC_013080.1 highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G-beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1; KLTH0D04466p 414238 8295143 KLTH0D04466g Lachancea thermotolerans CBS 6340 KLTH0D04466p XP_002552917.1 413024 D 559295 CDS KLTH0D04510g 255713272 8295761 414739..415074 1 NC_013080.1 similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources; KLTH0D04510p 415074 8295761 KLTH0D04510g Lachancea thermotolerans CBS 6340 KLTH0D04510p XP_002552918.1 414739 D 559295 CDS KLTH0D04532g 255713274 8295145 417085..419121 1 NC_013080.1 highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control; KLTH0D04532p 419121 8295145 KLTH0D04532g Lachancea thermotolerans CBS 6340 KLTH0D04532p XP_002552919.1 417085 D 559295 CDS KLTH0D04554g 255713276 8295146 419630..423418 1 NC_013080.1 similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline- rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3; KLTH0D04554p 423418 8295146 KLTH0D04554g Lachancea thermotolerans CBS 6340 KLTH0D04554p XP_002552920.1 419630 D 559295 CDS KLTH0D04576g 255713278 8295147 complement(423550..425121) 1 NC_013080.1 similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C; KLTH0D04576p 425121 8295147 KLTH0D04576g Lachancea thermotolerans CBS 6340 KLTH0D04576p XP_002552921.1 423550 R 559295 CDS KLTH0D04598g 255713280 8295148 425236..425946 1 NC_013080.1 similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; KLTH0D04598p 425946 8295148 KLTH0D04598g Lachancea thermotolerans CBS 6340 KLTH0D04598p XP_002552922.1 425236 D 559295 CDS KLTH0D04620g 255713282 8295149 complement(425980..427110) 1 NC_013080.1 weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C Hypothetical ORF; KLTH0D04620p 427110 8295149 KLTH0D04620g Lachancea thermotolerans CBS 6340 KLTH0D04620p XP_002552923.1 425980 R 559295 CDS KLTH0D04642g 255713284 8295150 complement(427725..428060) 1 NC_013080.1 similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme; KLTH0D04642p 428060 8295150 KLTH0D04642g Lachancea thermotolerans CBS 6340 KLTH0D04642p XP_002552924.1 427725 R 559295 CDS KLTH0D04664g 255713286 8295151 428209..429474 1 NC_013080.1 similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; KLTH0D04664p 429474 8295151 KLTH0D04664g Lachancea thermotolerans CBS 6340 KLTH0D04664p XP_002552925.1 428209 D 559295 CDS KLTH0D04686g 255713288 8295152 complement(429482..430489) 1 NC_013080.1 similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C Hypothetical ORF; KLTH0D04686p 430489 8295152 KLTH0D04686g Lachancea thermotolerans CBS 6340 KLTH0D04686p XP_002552926.1 429482 R 559295 CDS KLTH0D04708g 255713290 8295153 431011..432444 1 NC_013080.1 similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria; KLTH0D04708p 432444 8295153 KLTH0D04708g Lachancea thermotolerans CBS 6340 KLTH0D04708p XP_002552927.1 431011 D 559295 CDS KLTH0D04730g 255713292 8295154 432572..434890 1 NC_013080.1 similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis; KLTH0D04730p 434890 8295154 KLTH0D04730g Lachancea thermotolerans CBS 6340 KLTH0D04730p XP_002552928.1 432572 D 559295 CDS KLTH0D04774g 255713294 8295156 435339..437147 1 NC_013080.1 similar to uniprot|Q04437 Saccharomyces cerevisiae YMR106C YKU80 Forms heterodimer with Yku70p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes; KLTH0D04774p 437147 8295156 KLTH0D04774g Lachancea thermotolerans CBS 6340 KLTH0D04774p XP_002552929.1 435339 D 559295 CDS KLTH0D04796g 255713296 8295157 437416..439128 1 NC_013080.1 highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism; KLTH0D04796p 439128 8295157 KLTH0D04796g Lachancea thermotolerans CBS 6340 KLTH0D04796p XP_002552930.1 437416 D 559295 CDS KLTH0D04818g 255713298 8295158 439491..441566 1 NC_013080.1 similar to uniprot|P12688 Saccharomyces cerevisiae or to YMR 104C, YKL126W YPK1 Serine/threonine protein kinase required for receptor-mediated endocytosis involved in sphingolipid-mediated and cell integrity signaling pathways localized to the bud neck cytosol and plasma membrane homolog of mammalian kinase SGK; KLTH0D04818p 441566 8295158 KLTH0D04818g Lachancea thermotolerans CBS 6340 KLTH0D04818p XP_002552931.1 439491 D 559295 CDS KLTH0D04840g 255713300 8295159 join(441811..442005,442087..443730) 1 NC_013080.1 some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor; KLTH0D04840p 443730 8295159 KLTH0D04840g Lachancea thermotolerans CBS 6340 KLTH0D04840p XP_002552932.1 441811 D 559295 CDS KLTH0D04862g 255713302 8295160 complement(443978..445681) 1 NC_013080.1 similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W; KLTH0D04862p 445681 8295160 KLTH0D04862g Lachancea thermotolerans CBS 6340 KLTH0D04862p XP_002552933.1 443978 R 559295 CDS KLTH0D04884g 255713304 8295161 445884..446492 1 NC_013080.1 similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; KLTH0D04884p 446492 8295161 KLTH0D04884g Lachancea thermotolerans CBS 6340 KLTH0D04884p XP_002552934.1 445884 D 559295 CDS KLTH0D04906g 255713306 8295162 complement(446504..447592) 1 NC_013080.1 similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis; KLTH0D04906p 447592 8295162 KLTH0D04906g Lachancea thermotolerans CBS 6340 KLTH0D04906p XP_002552935.1 446504 R 559295 CDS KLTH0D04928g 255713308 8295163 complement(447820..448797) 1 NC_013080.1 highly similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family; KLTH0D04928p 448797 8295163 KLTH0D04928g Lachancea thermotolerans CBS 6340 KLTH0D04928p XP_002552936.1 447820 R 559295 CDS KLTH0D04950g 255713310 8295164 complement(449060..451402) 1 NC_013080.1 weakly similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; KLTH0D04950p 451402 8295164 KLTH0D04950g Lachancea thermotolerans CBS 6340 KLTH0D04950p XP_002552937.1 449060 R 559295 CDS KLTH0D04972g 255713312 8295165 451606..452004 1 NC_013080.1 weakly similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; KLTH0D04972p 452004 8295165 KLTH0D04972g Lachancea thermotolerans CBS 6340 KLTH0D04972p XP_002552938.1 451606 D 559295 CDS KLTH0D04994g 255713314 8295166 complement(452121..453644) 1 NC_013080.1 similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions; KLTH0D04994p 453644 8295166 KLTH0D04994g Lachancea thermotolerans CBS 6340 KLTH0D04994p XP_002552939.1 452121 R 559295 CDS KLTH0D05038g 255713316 8295168 455340..455918 1 NC_013080.1 similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W; KLTH0D05038p 455918 8295168 KLTH0D05038g Lachancea thermotolerans CBS 6340 KLTH0D05038p XP_002552940.1 455340 D 559295 CDS KLTH0D05060g 255713318 8295169 complement(456032..456922) 1 NC_013080.1 highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF; KLTH0D05060p 456922 8295169 KLTH0D05060g Lachancea thermotolerans CBS 6340 KLTH0D05060p XP_002552941.1 456032 R 559295 CDS KLTH0D05082g 255713320 8295170 complement(457124..458680) 1 NC_013080.1 similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway; KLTH0D05082p 458680 8295170 KLTH0D05082g Lachancea thermotolerans CBS 6340 KLTH0D05082p XP_002552942.1 457124 R 559295 CDS KLTH0D05104g 255713322 8295171 complement(458869..460086) 1 NC_013080.1 highly similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations; KLTH0D05104p 460086 8295171 KLTH0D05104g Lachancea thermotolerans CBS 6340 KLTH0D05104p XP_002552943.1 458869 R 559295 CDS KLTH0D05126g 255713324 8295172 complement(460113..461270) 1 NC_013080.1 similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family; KLTH0D05126p 461270 8295172 KLTH0D05126g Lachancea thermotolerans CBS 6340 KLTH0D05126p XP_002552944.1 460113 R 559295 CDS KLTH0D05148g 255713326 8295173 462673..464220 1 NC_013080.1 some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation gene silencing and DNA replication and repair; KLTH0D05148p 464220 8295173 KLTH0D05148g Lachancea thermotolerans CBS 6340 KLTH0D05148p XP_002552945.1 462673 D 559295 CDS KLTH0D05170g 255713328 8295174 464410..466272 1 NC_013080.1 weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF; KLTH0D05170p 466272 8295174 KLTH0D05170g Lachancea thermotolerans CBS 6340 KLTH0D05170p XP_002552946.1 464410 D 559295 CDS KLTH0D05192g 255713330 8295175 complement(466301..467233) 1 NC_013080.1 similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin; KLTH0D05192p 467233 8295175 KLTH0D05192g Lachancea thermotolerans CBS 6340 KLTH0D05192p XP_002552947.1 466301 R 559295 CDS KLTH0D05214g 255713332 8295176 467366..468493 1 NC_013080.1 similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane essential for respiratory competence likely functions in assembly of the large ribosomal subunit has homologs in plants and animals; KLTH0D05214p 468493 8295176 KLTH0D05214g Lachancea thermotolerans CBS 6340 KLTH0D05214p XP_002552948.1 467366 D 559295 CDS KLTH0D05236g 255713334 8295177 469109..470785 1 NC_013080.1 conserved hypothetical protein; KLTH0D05236p 470785 8295177 KLTH0D05236g Lachancea thermotolerans CBS 6340 KLTH0D05236p XP_002552949.1 469109 D 559295 CDS KLTH0D05258g 255713336 8295178 complement(471090..471977) 1 NC_013080.1 highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase- induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1; KLTH0D05258p 471977 8295178 KLTH0D05258g Lachancea thermotolerans CBS 6340 KLTH0D05258p XP_002552950.1 471090 R 559295 CDS KLTH0D05280g 255713338 8295179 472544..473308 1 NC_013080.1 similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1; KLTH0D05280p 473308 8295179 KLTH0D05280g Lachancea thermotolerans CBS 6340 KLTH0D05280p XP_002552951.1 472544 D 559295 CDS KLTH0D05302g 255713340 8295180 complement(473487..474623) 1 NC_013080.1 weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis; KLTH0D05302p 474623 8295180 KLTH0D05302g Lachancea thermotolerans CBS 6340 KLTH0D05302p XP_002552952.1 473487 R 559295 CDS KLTH0D05324g 255713342 8295181 474688..475833 1 NC_013080.1 weakly similar to uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Protein required for DNA replication phosphorylated in S phase by S-phase cyclin- dependent kinases (Cdks) phosphorylation is essential for DNA replication and for complex formation with Dpb11p potential Cdc28p substrate; KLTH0D05324p 475833 8295181 KLTH0D05324g Lachancea thermotolerans CBS 6340 KLTH0D05324p XP_002552953.1 474688 D 559295 CDS KLTH0D05346g 255713344 8295182 complement(475917..477440) 1 NC_013080.1 highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0D05346p 477440 8295182 KLTH0D05346g Lachancea thermotolerans CBS 6340 KLTH0D05346p XP_002552954.1 475917 R 559295 CDS KLTH0D05368g 255713346 8295183 479606..481438 1 NC_013080.1 similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4; KLTH0D05368p 481438 8295183 KLTH0D05368g Lachancea thermotolerans CBS 6340 KLTH0D05368p XP_002552955.1 479606 D 559295 CDS KLTH0D05390g 255713348 8295184 481640..482977 1 NC_013080.1 similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import; KLTH0D05390p 482977 8295184 KLTH0D05390g Lachancea thermotolerans CBS 6340 KLTH0D05390p XP_002552956.1 481640 D 559295 CDS KLTH0D05412g 255713350 8295185 483268..485709 1 NC_013080.1 similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; KLTH0D05412p 485709 8295185 KLTH0D05412g Lachancea thermotolerans CBS 6340 KLTH0D05412p XP_002552957.1 483268 D 559295 CDS KLTH0D05434g 255713352 8295186 486319..488049 1 NC_013080.1 similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; KLTH0D05434p 488049 8295186 KLTH0D05434g Lachancea thermotolerans CBS 6340 KLTH0D05434p XP_002552958.1 486319 D 559295 CDS KLTH0D05456g 255713354 8295187 complement(487952..488734) 1 NC_013080.1 similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain; KLTH0D05456p 488734 8295187 KLTH0D05456g Lachancea thermotolerans CBS 6340 KLTH0D05456p XP_002552959.1 487952 R 559295 CDS KLTH0D05478g 255713356 8295188 488881..490146 1 NC_013080.1 similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis; KLTH0D05478p 490146 8295188 KLTH0D05478g Lachancea thermotolerans CBS 6340 KLTH0D05478p XP_002552960.1 488881 D 559295 CDS KLTH0D05500g 255713358 8295189 complement(490531..492828) 1 NC_013080.1 weakly similar to uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0D05500p 492828 8295189 KLTH0D05500g Lachancea thermotolerans CBS 6340 KLTH0D05500p XP_002552961.1 490531 R 559295 CDS KLTH0D05522g 255713360 8295190 complement(493225..495330) 1 NC_013080.1 highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6- P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; KLTH0D05522p 495330 8295190 KLTH0D05522g Lachancea thermotolerans CBS 6340 KLTH0D05522p XP_002552962.1 493225 R 559295 CDS KLTH0D05544g 255713362 8295191 complement(495727..497262) 1 NC_013080.1 similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase; KLTH0D05544p 497262 8295191 KLTH0D05544g Lachancea thermotolerans CBS 6340 KLTH0D05544p XP_002552963.1 495727 R 559295 CDS KLTH0D05566g 255713364 8295192 498055..501441 1 NC_013080.1 weakly similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p; KLTH0D05566p 501441 8295192 KLTH0D05566g Lachancea thermotolerans CBS 6340 KLTH0D05566p XP_002552964.1 498055 D 559295 CDS KLTH0D05588g 255713366 8295193 complement(502176..503345) 1 NC_013080.1 similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 Alcohol dehydrogenase isoenzyme III; KLTH0D05588p 503345 8295193 KLTH0D05588g Lachancea thermotolerans CBS 6340 KLTH0D05588p XP_002552965.1 502176 R 559295 CDS KLTH0D05610g 255713368 8295194 503333..504055 1 NC_013080.1 no similarity; KLTH0D05610p 504055 8295194 KLTH0D05610g Lachancea thermotolerans CBS 6340 KLTH0D05610p XP_002552966.1 503333 D 559295 CDS KLTH0D05632g 255713370 8295195 complement(504315..505067) 1 NC_013080.1 similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0D05632p 505067 8295195 KLTH0D05632g Lachancea thermotolerans CBS 6340 KLTH0D05632p XP_002552967.1 504315 R 559295 CDS KLTH0D05654g 255713372 8295196 505266..506123 1 NC_013080.1 weakly similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF; KLTH0D05654p 506123 8295196 KLTH0D05654g Lachancea thermotolerans CBS 6340 KLTH0D05654p XP_002552968.1 505266 D 559295 CDS KLTH0D05676g 255713374 8295197 506564..507571 1 NC_013080.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization; KLTH0D05676p 507571 8295197 KLTH0D05676g Lachancea thermotolerans CBS 6340 KLTH0D05676p XP_002552969.1 506564 D 559295 CDS KLTH0D05698g 255713376 8295198 508215..510326 1 NC_013080.1 some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization; KLTH0D05698p 510326 8295198 KLTH0D05698g Lachancea thermotolerans CBS 6340 KLTH0D05698p XP_002552970.1 508215 D 559295 CDS KLTH0D05720g 255713378 8295199 511398..512216 1 NC_013080.1 similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data; KLTH0D05720p 512216 8295199 KLTH0D05720g Lachancea thermotolerans CBS 6340 KLTH0D05720p XP_002552971.1 511398 D 559295 CDS KLTH0D05742g 255713380 8295200 512469..513410 1 NC_013080.1 similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles; KLTH0D05742p 513410 8295200 KLTH0D05742g Lachancea thermotolerans CBS 6340 KLTH0D05742p XP_002552972.1 512469 D 559295 CDS KLTH0D05764g 255713382 8295201 513915..514739 1 NC_013080.1 conserved hypothetical protein; KLTH0D05764p 514739 8295201 KLTH0D05764g Lachancea thermotolerans CBS 6340 KLTH0D05764p XP_002552973.1 513915 D 559295 CDS KLTH0D05786g 255713384 8295202 515187..518135 1 NC_013080.1 highly similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; KLTH0D05786p 518135 8295202 KLTH0D05786g Lachancea thermotolerans CBS 6340 KLTH0D05786p XP_002552974.1 515187 D 559295 CDS KLTH0D05808g 255713386 8295203 complement(518280..521462) 1 NC_013080.1 similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types; KLTH0D05808p 521462 8295203 KLTH0D05808g Lachancea thermotolerans CBS 6340 KLTH0D05808p XP_002552975.1 518280 R 559295 CDS KLTH0D05830g 255713388 8295204 complement(521663..522352) 1 NC_013080.1 highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism products of which are regulators in Golgi to plasma membrane transport functionally homologous to mammalian PITPs; KLTH0D05830p 522352 8295204 KLTH0D05830g Lachancea thermotolerans CBS 6340 KLTH0D05830p XP_002552976.1 521663 R 559295 CDS KLTH0D05852g 255713390 8295205 522837..524945 1 NC_013080.1 similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint; KLTH0D05852p 524945 8295205 KLTH0D05852g Lachancea thermotolerans CBS 6340 KLTH0D05852p XP_002552977.1 522837 D 559295 CDS KLTH0D05918g 255713392 8295208 526400..527332 1 NC_013080.1 some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor; KLTH0D05918p 527332 8295208 KLTH0D05918g Lachancea thermotolerans CBS 6340 KLTH0D05918p XP_002552978.1 526400 D 559295 CDS KLTH0D05940g 255713394 8295209 527462..528160 1 NC_013080.1 conserved hypothetical protein; KLTH0D05940p 528160 8295209 KLTH0D05940g Lachancea thermotolerans CBS 6340 KLTH0D05940p XP_002552979.1 527462 D 559295 CDS KLTH0D05962g 255713396 8295210 529126..530502 1 NC_013080.1 similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination; KLTH0D05962p 530502 8295210 KLTH0D05962g Lachancea thermotolerans CBS 6340 KLTH0D05962p XP_002552980.1 529126 D 559295 CDS KLTH0D05984g 255713398 8295211 530632..532383 1 NC_013080.1 similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p; KLTH0D05984p 532383 8295211 KLTH0D05984g Lachancea thermotolerans CBS 6340 KLTH0D05984p XP_002552981.1 530632 D 559295 CDS KLTH0D06006g 255713400 8295212 complement(532589..535453) 1 NC_013080.1 similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21- activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases; KLTH0D06006p 535453 8295212 KLTH0D06006g Lachancea thermotolerans CBS 6340 KLTH0D06006p XP_002552982.1 532589 R 559295 CDS KLTH0D06028g 255713402 8295213 complement(535827..540188) 1 NC_013080.1 similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; KLTH0D06028p 540188 8295213 KLTH0D06028g Lachancea thermotolerans CBS 6340 KLTH0D06028p XP_002552983.1 535827 R 559295 CDS KLTH0D06050g 255713404 8295214 540476..541192 1 NC_013080.1 highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus; KLTH0D06050p 541192 8295214 KLTH0D06050g Lachancea thermotolerans CBS 6340 KLTH0D06050p XP_002552984.1 540476 D 559295 CDS KLTH0D06072g 255713406 8295215 complement(541229..541690) 1 NC_013080.1 conserved hypothetical protein; KLTH0D06072p 541690 8295215 KLTH0D06072g Lachancea thermotolerans CBS 6340 KLTH0D06072p XP_002552985.1 541229 R 559295 CDS KLTH0D06094g 255713408 8295216 541858..543066 1 NC_013080.1 similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit; KLTH0D06094p 543066 8295216 KLTH0D06094g Lachancea thermotolerans CBS 6340 KLTH0D06094p XP_002552986.1 541858 D 559295 CDS KLTH0D06116g 255713410 8295217 complement(543221..544486) 1 NC_013080.1 highly similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p and highly similar to YKL008C uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p; KLTH0D06116p 544486 8295217 KLTH0D06116g Lachancea thermotolerans CBS 6340 KLTH0D06116p XP_002552987.1 543221 R 559295 CDS KLTH0D06138g 255713412 8295218 544661..546130 1 NC_013080.1 similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p- Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation as well as for recycling of Golgi proteins and formation of lumenal membranes; KLTH0D06138p 546130 8295218 KLTH0D06138g Lachancea thermotolerans CBS 6340 KLTH0D06138p XP_002552988.1 544661 D 559295 CDS KLTH0D06160g 255713414 8295219 546275..547069 1 NC_013080.1 similar to uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches; KLTH0D06160p 547069 8295219 KLTH0D06160g Lachancea thermotolerans CBS 6340 KLTH0D06160p XP_002552989.1 546275 D 559295 CDS KLTH0D06182g 255713416 8295220 complement(join(547103..547360,547428..547463)) 1 NC_013080.1 highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment; KLTH0D06182p 547463 8295220 KLTH0D06182g Lachancea thermotolerans CBS 6340 KLTH0D06182p XP_002552990.1 547103 R 559295 CDS KLTH0D06204g 255713418 8295221 join(548471..548599,548771..549058) 1 NC_013080.1 highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit; KLTH0D06204p 549058 8295221 KLTH0D06204g Lachancea thermotolerans CBS 6340 KLTH0D06204p XP_002552991.1 548471 D 559295 CDS KLTH0D06226g 255713420 8295222 complement(549266..550918) 1 NC_013080.1 weakly similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation contains a TFIIS-like domain and a PHD finger multicopy suppressor of temperature-sensitive ess1 mutations probably binds RNA polymerase II large subunit; KLTH0D06226p 550918 8295222 KLTH0D06226g Lachancea thermotolerans CBS 6340 KLTH0D06226p XP_002552992.1 549266 R 559295 CDS KLTH0D06248g 255713422 8295223 551316..552560 1 NC_013080.1 similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance; KLTH0D06248p 552560 8295223 KLTH0D06248g Lachancea thermotolerans CBS 6340 KLTH0D06248p XP_002552993.1 551316 D 559295 CDS KLTH0D06270g 255713424 8295224 complement(552705..553133) 1 NC_013080.1 highly similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator; KLTH0D06270p 553133 8295224 KLTH0D06270g Lachancea thermotolerans CBS 6340 KLTH0D06270p XP_002552994.1 552705 R 559295 CDS KLTH0D06292g 255713426 8295225 join(553292..553351,553408..554037) 1 NC_013080.1 highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT- III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis; KLTH0D06292p 554037 8295225 KLTH0D06292g Lachancea thermotolerans CBS 6340 KLTH0D06292p XP_002552995.1 553292 D 559295 CDS KLTH0D06314g 255713428 8295226 complement(join(554066..554549,554601..554713)) 1 NC_013080.1 similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism; KLTH0D06314p 554713 8295226 KLTH0D06314g Lachancea thermotolerans CBS 6340 KLTH0D06314p XP_002552996.1 554066 R 559295 CDS KLTH0D06358g 255713430 8295228 complement(555635..557710) 1 NC_013080.1 highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p; KLTH0D06358p 557710 8295228 KLTH0D06358g Lachancea thermotolerans CBS 6340 KLTH0D06358p XP_002552997.1 555635 R 559295 CDS KLTH0D06380g 255713432 8295229 558139..559923 1 NC_013080.1 similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs; KLTH0D06380p 559923 8295229 KLTH0D06380g Lachancea thermotolerans CBS 6340 KLTH0D06380p XP_002552998.1 558139 D 559295 CDS KLTH0D06402g 255713434 8295230 560246..561547 1 NC_013080.1 highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; KLTH0D06402p 561547 8295230 KLTH0D06402g Lachancea thermotolerans CBS 6340 KLTH0D06402p XP_002552999.1 560246 D 559295 CDS KLTH0D06424g 255713436 8295231 complement(join(561640..562556,562614..562842)) 1 NC_013080.1 weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function; KLTH0D06424p 562842 8295231 KLTH0D06424g Lachancea thermotolerans CBS 6340 KLTH0D06424p XP_002553000.1 561640 R 559295 CDS KLTH0D06446g 255713438 8295232 complement(563713..564462) 1 NC_013080.1 similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; KLTH0D06446p 564462 8295232 KLTH0D06446g Lachancea thermotolerans CBS 6340 KLTH0D06446p XP_002553001.1 563713 R 559295 CDS KLTH0D06468g 255713440 8295233 564646..565104 1 NC_013080.1 some similarities with uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1; KLTH0D06468p 565104 8295233 KLTH0D06468g Lachancea thermotolerans CBS 6340 KLTH0D06468p XP_002553002.1 564646 D 559295 CDS KLTH0D06490g 255713442 8295234 565317..566975 1 NC_013080.1 similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling; KLTH0D06490p 566975 8295234 KLTH0D06490g Lachancea thermotolerans CBS 6340 KLTH0D06490p XP_002553003.1 565317 D 559295 CDS KLTH0D06512g 255713444 8295235 join(567443..567451,567584..567811) 1 NC_013080.1 similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex; KLTH0D06512p 567811 8295235 KLTH0D06512g Lachancea thermotolerans CBS 6340 KLTH0D06512p XP_002553004.1 567443 D 559295 CDS KLTH0D06534g 255713446 8295236 complement(568047..570752) 1 NC_013080.1 similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3- hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; KLTH0D06534p 570752 8295236 KLTH0D06534g Lachancea thermotolerans CBS 6340 KLTH0D06534p XP_002553005.1 568047 R 559295 CDS KLTH0D06556g 255713448 8295237 complement(570972..572342) 1 NC_013080.1 similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain; KLTH0D06556p 572342 8295237 KLTH0D06556g Lachancea thermotolerans CBS 6340 KLTH0D06556p XP_002553006.1 570972 R 559295 CDS KLTH0D06578g 255713450 8295238 572515..574866 1 NC_013080.1 some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex; KLTH0D06578p 574866 8295238 KLTH0D06578g Lachancea thermotolerans CBS 6340 KLTH0D06578p XP_002553007.1 572515 D 559295 CDS KLTH0D06600g 255713452 8295239 574893..575855 1 NC_013080.1 similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification; KLTH0D06600p 575855 8295239 KLTH0D06600g Lachancea thermotolerans CBS 6340 KLTH0D06600p XP_002553008.1 574893 D 559295 CDS KLTH0D06622g 255713454 8295240 complement(575930..576823) 1 NC_013080.1 highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family; KLTH0D06622p 576823 8295240 KLTH0D06622g Lachancea thermotolerans CBS 6340 KLTH0D06622p XP_002553009.1 575930 R 559295 CDS KLTH0D06644g 255713456 8295241 578225..579274 1 NC_013080.1 similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized; KLTH0D06644p 579274 8295241 KLTH0D06644g Lachancea thermotolerans CBS 6340 KLTH0D06644p XP_002553010.1 578225 D 559295 CDS KLTH0D06666g 255713458 8295242 complement(579343..580686) 1 NC_013080.1 similar to uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF; KLTH0D06666p 580686 8295242 KLTH0D06666g Lachancea thermotolerans CBS 6340 KLTH0D06666p XP_002553011.1 579343 R 559295 CDS KLTH0D06688g 255713460 8295243 complement(580861..582213) 1 NC_013080.1 similar to uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening; KLTH0D06688p 582213 8295243 KLTH0D06688g Lachancea thermotolerans CBS 6340 KLTH0D06688p XP_002553012.1 580861 R 559295 CDS KLTH0D06710g 255713462 8295244 complement(582430..584265) 1 NC_013080.1 weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake; KLTH0D06710p 584265 8295244 KLTH0D06710g Lachancea thermotolerans CBS 6340 KLTH0D06710p XP_002553013.1 582430 R 559295 CDS KLTH0D06732g 255713464 8295245 585777..587738 1 NC_013080.1 similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; KLTH0D06732p 587738 8295245 KLTH0D06732g Lachancea thermotolerans CBS 6340 KLTH0D06732p XP_002553014.1 585777 D 559295 CDS KLTH0D06754g 255713466 8295246 complement(588021..590504) 1 NC_013080.1 highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family; KLTH0D06754p 590504 8295246 KLTH0D06754g Lachancea thermotolerans CBS 6340 KLTH0D06754p XP_002553015.1 588021 R 559295 CDS KLTH0D06776g 255713468 8295247 complement(591149..592378) 1 NC_013080.1 similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation; KLTH0D06776p 592378 8295247 KLTH0D06776g Lachancea thermotolerans CBS 6340 KLTH0D06776p XP_002553016.1 591149 R 559295 CDS KLTH0D06798g 255713470 8295248 complement(594639..594974) 1 NC_013080.1 some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF; KLTH0D06798p 594974 8295248 KLTH0D06798g Lachancea thermotolerans CBS 6340 KLTH0D06798p XP_002553017.1 594639 R 559295 CDS KLTH0D06820g 255713472 8295249 596520..597302 1 NC_013080.1 some similarities with uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl- transferase involved in acetylation of the N-terminal residues of histones H4 and H2A; KLTH0D06820p 597302 8295249 KLTH0D06820g Lachancea thermotolerans CBS 6340 KLTH0D06820p XP_002553018.1 596520 D 559295 CDS KLTH0D06842g 255713474 8295250 597659..599179 1 NC_013080.1 some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes; KLTH0D06842p 599179 8295250 KLTH0D06842g Lachancea thermotolerans CBS 6340 KLTH0D06842p XP_002553019.1 597659 D 559295 CDS KLTH0D06864g 255713476 8295251 complement(join(599324..599756,599835..599905)) 1 NC_013080.1 highly similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein; KLTH0D06864p 599905 8295251 KLTH0D06864g Lachancea thermotolerans CBS 6340 KLTH0D06864p XP_002553020.1 599324 R 559295 CDS KLTH0D06886g 255713478 8295252 600181..602175 1 NC_013080.1 conserved hypothetical protein; KLTH0D06886p 602175 8295252 KLTH0D06886g Lachancea thermotolerans CBS 6340 KLTH0D06886p XP_002553021.1 600181 D 559295 CDS KLTH0D06908g 255713480 8295253 603521..604666 1 NC_013080.1 some similarities with uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b; KLTH0D06908p 604666 8295253 KLTH0D06908g Lachancea thermotolerans CBS 6340 KLTH0D06908p XP_002553022.1 603521 D 559295 CDS KLTH0D06930g 255713482 8295254 complement(604805..605419) 1 NC_013080.1 weakly similar to uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF; KLTH0D06930p 605419 8295254 KLTH0D06930g Lachancea thermotolerans CBS 6340 KLTH0D06930p XP_002553023.1 604805 R 559295 CDS KLTH0D06974g 255713484 8295255 608167..609231 1 NC_013080.1 conserved hypothetical protein; KLTH0D06974p 609231 8295255 KLTH0D06974g Lachancea thermotolerans CBS 6340 KLTH0D06974p XP_002553024.1 608167 D 559295 CDS KLTH0D06996g 255713486 8295256 complement(609406..611460) 1 NC_013080.1 conserved hypothetical protein; KLTH0D06996p 611460 8295256 KLTH0D06996g Lachancea thermotolerans CBS 6340 KLTH0D06996p XP_002553025.1 609406 R 559295 CDS KLTH0D07018g 255713488 8295257 complement(join(611733..612048,612118..612215)) 1 NC_013080.1 some similarities with uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF; KLTH0D07018p 612215 8295257 KLTH0D07018g Lachancea thermotolerans CBS 6340 KLTH0D07018p XP_002553026.1 611733 R 559295 CDS KLTH0D07040g 255713490 8295258 612872..614896 1 NC_013080.1 similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function; KLTH0D07040p 614896 8295258 KLTH0D07040g Lachancea thermotolerans CBS 6340 KLTH0D07040p XP_002553027.1 612872 D 559295 CDS KLTH0D07062g 255713492 8295259 complement(615021..618899) 1 NC_013080.1 similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold; KLTH0D07062p 618899 8295259 KLTH0D07062g Lachancea thermotolerans CBS 6340 KLTH0D07062p XP_002553028.1 615021 R 559295 CDS KLTH0D07084g 255713494 8295260 complement(619124..621115) 1 NC_013080.1 some similarities with uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF; KLTH0D07084p 621115 8295260 KLTH0D07084g Lachancea thermotolerans CBS 6340 KLTH0D07084p XP_002553029.1 619124 R 559295 CDS KLTH0D07106g 255713496 8295261 complement(621467..624595) 1 NC_013080.1 similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm.; KLTH0D07106p 624595 8295261 KLTH0D07106g Lachancea thermotolerans CBS 6340 KLTH0D07106p XP_002553030.1 621467 R 559295 CDS KLTH0D07128g 255713498 8295262 complement(624863..626494) 1 NC_013080.1 similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids; KLTH0D07128p 626494 8295262 KLTH0D07128g Lachancea thermotolerans CBS 6340 KLTH0D07128p XP_002553031.1 624863 R 559295 CDS KLTH0D07150g 255713500 8295263 627115..628737 1 NC_013080.1 similar to uniprot|P38748 Saccharomyces cerevisiae YHL010C Hypothetical ORF; KLTH0D07150p 628737 8295263 KLTH0D07150g Lachancea thermotolerans CBS 6340 KLTH0D07150p XP_002553032.1 627115 D 559295 CDS KLTH0D07172g 255713502 8295264 629258..630220 1 NC_013080.1 highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; KLTH0D07172p 630220 8295264 KLTH0D07172g Lachancea thermotolerans CBS 6340 KLTH0D07172p XP_002553033.1 629258 D 559295 CDS KLTH0D07194g 255713504 8295265 complement(630316..630987) 1 NC_013080.1 conserved hypothetical protein; KLTH0D07194p 630987 8295265 KLTH0D07194g Lachancea thermotolerans CBS 6340 KLTH0D07194p XP_002553034.1 630316 R 559295 CDS KLTH0D07216g 255713506 8295266 complement(631219..633462) 1 NC_013080.1 similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase; KLTH0D07216p 633462 8295266 KLTH0D07216g Lachancea thermotolerans CBS 6340 KLTH0D07216p XP_002553035.1 631219 R 559295 CDS KLTH0D07238g 255713508 8295267 complement(633807..635306) 1 NC_013080.1 KLTH0D07238p 635306 8295267 KLTH0D07238g Lachancea thermotolerans CBS 6340 KLTH0D07238p XP_002553036.1 633807 R 559295 CDS KLTH0D07260g 255713510 8295268 complement(635598..638537) 1 NC_013080.1 some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor; KLTH0D07260p 638537 8295268 KLTH0D07260g Lachancea thermotolerans CBS 6340 KLTH0D07260p XP_002553037.1 635598 R 559295 CDS KLTH0D07304g 255713512 8295270 639765..640724 1 NC_013080.1 similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF; KLTH0D07304p 640724 8295270 KLTH0D07304g Lachancea thermotolerans CBS 6340 KLTH0D07304p XP_002553038.1 639765 D 559295 CDS KLTH0D07326g 255713514 8295271 640849..642096 1 NC_013080.1 similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; KLTH0D07326p 642096 8295271 KLTH0D07326g Lachancea thermotolerans CBS 6340 KLTH0D07326p XP_002553039.1 640849 D 559295 CDS KLTH0D07370g 255713516 8295753 complement(642839..643195) 1 NC_013080.1 similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20; KLTH0D07370p 643195 8295753 KLTH0D07370g Lachancea thermotolerans CBS 6340 KLTH0D07370p XP_002553040.1 642839 R 559295 CDS KLTH0D07392g 255713518 8295273 643756..645102 1 NC_013080.1 conserved hypothetical protein; KLTH0D07392p 645102 8295273 KLTH0D07392g Lachancea thermotolerans CBS 6340 KLTH0D07392p XP_002553041.1 643756 D 559295 CDS KLTH0D07414g 255713520 8295274 645479..647713 1 NC_013080.1 similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; KLTH0D07414p 647713 8295274 KLTH0D07414g Lachancea thermotolerans CBS 6340 KLTH0D07414p XP_002553042.1 645479 D 559295 CDS KLTH0D07436g 255713522 8295275 complement(647819..649285) 1 NC_013080.1 similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein; KLTH0D07436p 649285 8295275 KLTH0D07436g Lachancea thermotolerans CBS 6340 KLTH0D07436p XP_002553043.1 647819 R 559295 CDS KLTH0D07458g 255713524 8295276 649564..650310 1 NC_013080.1 similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C; KLTH0D07458p 650310 8295276 KLTH0D07458g Lachancea thermotolerans CBS 6340 KLTH0D07458p XP_002553044.1 649564 D 559295 CDS KLTH0D07480g 255713526 8295277 complement(650375..650704) 1 NC_013080.1 similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF; KLTH0D07480p 650704 8295277 KLTH0D07480g Lachancea thermotolerans CBS 6340 KLTH0D07480p XP_002553045.1 650375 R 559295 CDS KLTH0D07502g 255713528 8295278 650799..652313 1 NC_013080.1 similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins; KLTH0D07502p 652313 8295278 KLTH0D07502g Lachancea thermotolerans CBS 6340 KLTH0D07502p XP_002553046.1 650799 D 559295 CDS KLTH0D07524g 255713530 8295279 complement(652426..653796) 1 NC_013080.1 conserved hypothetical protein; KLTH0D07524p 653796 8295279 KLTH0D07524g Lachancea thermotolerans CBS 6340 KLTH0D07524p XP_002553047.1 652426 R 559295 CDS KLTH0D07546g 255713532 8295280 653992..655125 1 NC_013080.1 some similarities with uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; KLTH0D07546p 655125 8295280 KLTH0D07546g Lachancea thermotolerans CBS 6340 KLTH0D07546p XP_002553048.1 653992 D 559295 CDS KLTH0D07568g 255713534 8295281 complement(655143..655811) 1 NC_013080.1 similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion; KLTH0D07568p 655811 8295281 KLTH0D07568g Lachancea thermotolerans CBS 6340 KLTH0D07568p XP_002553049.1 655143 R 559295 CDS KLTH0D07590g 255713536 8295284 657085..660924 1 NC_013080.1 similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W; KLTH0D07590p 660924 8295284 KLTH0D07590g Lachancea thermotolerans CBS 6340 KLTH0D07590p XP_002553050.1 657085 D 559295 CDS KLTH0D07634g 255713538 8295283 complement(661066..662568) 1 NC_013080.1 weakly similar to uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol-P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation; KLTH0D07634p 662568 8295283 KLTH0D07634g Lachancea thermotolerans CBS 6340 KLTH0D07634p XP_002553051.1 661066 R 559295 CDS KLTH0D07810g 255713540 8295754 664551..666038 1 NC_013080.1 similar to uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0D07810p 666038 8295754 KLTH0D07810g Lachancea thermotolerans CBS 6340 KLTH0D07810p XP_002553052.1 664551 D 559295 CDS KLTH0D07832g 255713542 8295286 complement(666271..667869) 1 NC_013080.1 highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs; KLTH0D07832p 667869 8295286 KLTH0D07832g Lachancea thermotolerans CBS 6340 KLTH0D07832p XP_002553053.1 666271 R 559295 CDS KLTH0D07854g 255713544 8295287 complement(668300..669376) 1 NC_013080.1 weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB) involved in SPB duplication may facilitate attachment of the SPB to the nuclear membrane; KLTH0D07854p 669376 8295287 KLTH0D07854g Lachancea thermotolerans CBS 6340 KLTH0D07854p XP_002553054.1 668300 R 559295 CDS KLTH0D07876g 255713546 8295288 complement(669644..671941) 1 NC_013080.1 some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors; KLTH0D07876p 671941 8295288 KLTH0D07876g Lachancea thermotolerans CBS 6340 KLTH0D07876p XP_002553055.1 669644 R 559295 CDS KLTH0D07898g 255713548 8295289 672516..674534 1 NC_013080.1 weakly similar to uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two- hybrid assay; KLTH0D07898p 674534 8295289 KLTH0D07898g Lachancea thermotolerans CBS 6340 KLTH0D07898p XP_002553056.1 672516 D 559295 CDS KLTH0D07920g 255713550 8295290 complement(674563..676083) 1 NC_013080.1 highly similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair; KLTH0D07920p 676083 8295290 KLTH0D07920g Lachancea thermotolerans CBS 6340 KLTH0D07920p XP_002553057.1 674563 R 559295 CDS KLTH0D07942g 255713552 8295291 676761..678263 1 NC_013080.1 similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis; KLTH0D07942p 678263 8295291 KLTH0D07942g Lachancea thermotolerans CBS 6340 KLTH0D07942p XP_002553058.1 676761 D 559295 CDS KLTH0D07964g 255713554 8295292 complement(678368..679543) 1 NC_013080.1 similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport; KLTH0D07964p 679543 8295292 KLTH0D07964g Lachancea thermotolerans CBS 6340 KLTH0D07964p XP_002553059.1 678368 R 559295 CDS KLTH0D07986g 255713556 8295293 679875..680372 1 NC_013080.1 highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly; KLTH0D07986p 680372 8295293 KLTH0D07986g Lachancea thermotolerans CBS 6340 KLTH0D07986p XP_002553060.1 679875 D 559295 CDS KLTH0D08008g 255713558 8295294 680735..682081 1 NC_013080.1 highly similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p; KLTH0D08008p 682081 8295294 KLTH0D08008g Lachancea thermotolerans CBS 6340 KLTH0D08008p XP_002553061.1 680735 D 559295 CDS KLTH0D08030g 255713560 8295295 complement(682139..683698) 1 NC_013080.1 similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF; KLTH0D08030p 683698 8295295 KLTH0D08030g Lachancea thermotolerans CBS 6340 KLTH0D08030p XP_002553062.1 682139 R 559295 CDS KLTH0D08052g 255713562 8295296 683787..684128 1 NC_013080.1 conserved hypothetical protein; KLTH0D08052p 684128 8295296 KLTH0D08052g Lachancea thermotolerans CBS 6340 KLTH0D08052p XP_002553063.1 683787 D 559295 CDS KLTH0D08074g 255713564 8295297 complement(684208..685701) 1 NC_013080.1 similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C; KLTH0D08074p 685701 8295297 KLTH0D08074g Lachancea thermotolerans CBS 6340 KLTH0D08074p XP_002553064.1 684208 R 559295 CDS KLTH0D08118g 255713566 8295299 686143..687060 1 NC_013080.1 conserved hypothetical protein; KLTH0D08118p 687060 8295299 KLTH0D08118g Lachancea thermotolerans CBS 6340 KLTH0D08118p XP_002553065.1 686143 D 559295 CDS KLTH0D08140g 255713568 8295300 687366..688490 1 NC_013080.1 similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit; KLTH0D08140p 688490 8295300 KLTH0D08140g Lachancea thermotolerans CBS 6340 KLTH0D08140p XP_002553066.1 687366 D 559295 CDS KLTH0D08162g 255713570 8295301 688657..689418 1 NC_013080.1 conserved hypothetical protein; KLTH0D08162p 689418 8295301 KLTH0D08162g Lachancea thermotolerans CBS 6340 KLTH0D08162p XP_002553067.1 688657 D 559295 CDS KLTH0D08184g 255713572 8295302 complement(689421..690575) 1 NC_013080.1 similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p; KLTH0D08184p 690575 8295302 KLTH0D08184g Lachancea thermotolerans CBS 6340 KLTH0D08184p XP_002553068.1 689421 R 559295 CDS KLTH0D08250g 255713574 8295305 complement(693583..694662) 1 NC_013080.1 highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis; KLTH0D08250p 694662 8295305 KLTH0D08250g Lachancea thermotolerans CBS 6340 KLTH0D08250p XP_002553069.1 693583 R 559295 CDS KLTH0D08272g 255713576 8295306 complement(695296..696987) 1 NC_013080.1 highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose- ethanol- and autoregulation involved in amino acid catabolism and to YLR134W uniprot|P16467 Saccharomyces cerevisiae YLR134W PDC5 Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism; KLTH0D08272p 696987 8295306 KLTH0D08272g Lachancea thermotolerans CBS 6340 KLTH0D08272p XP_002553070.1 695296 R 559295 CDS KLTH0D08294g 255713578 8295307 697828..699273 1 NC_013080.1 similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition; KLTH0D08294p 699273 8295307 KLTH0D08294g Lachancea thermotolerans CBS 6340 KLTH0D08294p XP_002553071.1 697828 D 559295 CDS KLTH0D08316g 255713580 8295308 complement(699342..700532) 1 NC_013080.1 similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA- binding zinc knuckle motif; KLTH0D08316p 700532 8295308 KLTH0D08316g Lachancea thermotolerans CBS 6340 KLTH0D08316p XP_002553072.1 699342 R 559295 CDS KLTH0D08338g 255713582 8295309 700660..701007 1 NC_013080.1 highly similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain; KLTH0D08338p 701007 8295309 KLTH0D08338g Lachancea thermotolerans CBS 6340 KLTH0D08338p XP_002553073.1 700660 D 559295 CDS KLTH0D08360g 255713584 8295310 701141..702229 1 NC_013080.1 similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; KLTH0D08360p 702229 8295310 KLTH0D08360g Lachancea thermotolerans CBS 6340 KLTH0D08360p XP_002553074.1 701141 D 559295 CDS KLTH0D08382g 255713586 8295311 complement(702287..705355) 1 NC_013080.1 similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; KLTH0D08382p 705355 8295311 KLTH0D08382g Lachancea thermotolerans CBS 6340 KLTH0D08382p XP_002553075.1 702287 R 559295 CDS KLTH0D08404g 255713588 8295312 complement(705772..707580) 1 NC_013080.1 some similarities with uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p; KLTH0D08404p 707580 8295312 KLTH0D08404g Lachancea thermotolerans CBS 6340 KLTH0D08404p XP_002553076.1 705772 R 559295 CDS KLTH0D08426g 255713590 8295313 complement(707761..708264) 1 NC_013080.1 highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF; KLTH0D08426p 708264 8295313 KLTH0D08426g Lachancea thermotolerans CBS 6340 KLTH0D08426p XP_002553077.1 707761 R 559295 CDS KLTH0D08448g 255713592 8295314 complement(708475..709272) 1 NC_013080.1 similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl- carrier- protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p; KLTH0D08448p 709272 8295314 KLTH0D08448g Lachancea thermotolerans CBS 6340 KLTH0D08448p XP_002553078.1 708475 R 559295 CDS KLTH0D08470g 255713594 8295315 complement(709655..711856) 1 NC_013080.1 some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII; KLTH0D08470p 711856 8295315 KLTH0D08470g Lachancea thermotolerans CBS 6340 KLTH0D08470p XP_002553079.1 709655 R 559295 CDS KLTH0D08492g 255713596 8295316 complement(712735..713001) 1 NC_013080.1 highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology; KLTH0D08492p 713001 8295316 KLTH0D08492g Lachancea thermotolerans CBS 6340 KLTH0D08492p XP_002553080.1 712735 R 559295 CDS KLTH0D08514g 255713598 8295317 complement(713189..713944) 1 NC_013080.1 weakly similar to uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases; KLTH0D08514p 713944 8295317 KLTH0D08514g Lachancea thermotolerans CBS 6340 KLTH0D08514p XP_002553081.1 713189 R 559295 CDS KLTH0D08536g 255713600 8295318 714887..715843 1 NC_013080.1 similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W; KLTH0D08536p 715843 8295318 KLTH0D08536g Lachancea thermotolerans CBS 6340 KLTH0D08536p XP_002553082.1 714887 D 559295 CDS KLTH0D08558g 255713602 8295319 complement(715949..718741) 1 NC_013080.1 similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0D08558p 718741 8295319 KLTH0D08558g Lachancea thermotolerans CBS 6340 KLTH0D08558p XP_002553083.1 715949 R 559295 CDS KLTH0D08580g 255713604 8295320 719409..721211 1 NC_013080.1 similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain- containing protein required for cytokinesis; KLTH0D08580p 721211 8295320 KLTH0D08580g Lachancea thermotolerans CBS 6340 KLTH0D08580p XP_002553084.1 719409 D 559295 CDS KLTH0D08602g 255713606 8295321 complement(721268..721804) 1 NC_013080.1 highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A; KLTH0D08602p 721804 8295321 KLTH0D08602g Lachancea thermotolerans CBS 6340 KLTH0D08602p XP_002553085.1 721268 R 559295 CDS KLTH0D08624g 255713608 8295322 722066..723364 1 NC_013080.1 similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein; KLTH0D08624p 723364 8295322 KLTH0D08624g Lachancea thermotolerans CBS 6340 KLTH0D08624p XP_002553086.1 722066 D 559295 CDS KLTH0D08646g 255713610 8295323 complement(723457..724752) 1 NC_013080.1 similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Hypothetical ORF; KLTH0D08646p 724752 8295323 KLTH0D08646g Lachancea thermotolerans CBS 6340 KLTH0D08646p XP_002553087.1 723457 R 559295 CDS KLTH0D08668g 255713612 8295324 725208..725738 1 NC_013080.1 similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase; KLTH0D08668p 725738 8295324 KLTH0D08668g Lachancea thermotolerans CBS 6340 KLTH0D08668p XP_002553088.1 725208 D 559295 CDS KLTH0D08690g 255713614 8295325 complement(725899..727617) 1 NC_013080.1 some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25; KLTH0D08690p 727617 8295325 KLTH0D08690g Lachancea thermotolerans CBS 6340 KLTH0D08690p XP_002553089.1 725899 R 559295 CDS KLTH0D08712g 255713616 8295326 complement(728072..729886) 1 NC_013080.1 similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring; KLTH0D08712p 729886 8295326 KLTH0D08712g Lachancea thermotolerans CBS 6340 KLTH0D08712p XP_002553090.1 728072 R 559295 CDS KLTH0D08734g 255713618 8295327 complement(730214..732247) 1 NC_013080.1 similar to uniprot|P33749 Saccharomyces cerevisiae YKL062W MSN4 Transcriptional activator related to Msn2p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression; KLTH0D08734p 732247 8295327 KLTH0D08734g Lachancea thermotolerans CBS 6340 KLTH0D08734p XP_002553091.1 730214 R 559295 CDS KLTH0D08756g 255713620 8295328 733064..733627 1 NC_013080.1 similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C; KLTH0D08756p 733627 8295328 KLTH0D08756g Lachancea thermotolerans CBS 6340 KLTH0D08756p XP_002553092.1 733064 D 559295 CDS KLTH0D08778g 255713622 8295329 complement(733758..734492) 1 NC_013080.1 similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2- Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; KLTH0D08778p 734492 8295329 KLTH0D08778g Lachancea thermotolerans CBS 6340 KLTH0D08778p XP_002553093.1 733758 R 559295 CDS KLTH0D08800g 255713624 8295330 complement(734724..737456) 1 NC_013080.1 similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W; KLTH0D08800p 737456 8295330 KLTH0D08800g Lachancea thermotolerans CBS 6340 KLTH0D08800p XP_002553094.1 734724 R 559295 CDS KLTH0D08822g 255713626 8295331 complement(737718..738518) 1 NC_013080.1 some similarities with uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator; KLTH0D08822p 738518 8295331 KLTH0D08822g Lachancea thermotolerans CBS 6340 KLTH0D08822p XP_002553095.1 737718 R 559295 CDS KLTH0D08844g 255713628 8295332 738727..739749 1 NC_013080.1 similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF; KLTH0D08844p 739749 8295332 KLTH0D08844g Lachancea thermotolerans CBS 6340 KLTH0D08844p XP_002553096.1 738727 D 559295 CDS KLTH0D08866g 255713630 8295333 complement(739836..740459) 1 NC_013080.1 similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein; KLTH0D08866p 740459 8295333 KLTH0D08866g Lachancea thermotolerans CBS 6340 KLTH0D08866p XP_002553097.1 739836 R 559295 CDS KLTH0D08910g 255713632 8295335 741531..742505 1 NC_013080.1 some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C; KLTH0D08910p 742505 8295335 KLTH0D08910g Lachancea thermotolerans CBS 6340 KLTH0D08910p XP_002553098.1 741531 D 559295 CDS KLTH0D08932g 255713634 8295336 join(742772..742786,742899..743762) 1 NC_013080.1 similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; KLTH0D08932p 743762 8295336 KLTH0D08932g Lachancea thermotolerans CBS 6340 KLTH0D08932p XP_002553099.1 742772 D 559295 CDS KLTH0D08954g 255713636 8295337 complement(743851..744231) 1 NC_013080.1 similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins; KLTH0D08954p 744231 8295337 KLTH0D08954g Lachancea thermotolerans CBS 6340 KLTH0D08954p XP_002553100.1 743851 R 559295 CDS KLTH0D08976g 255713638 8295338 744374..744991 1 NC_013080.1 highly similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA; KLTH0D08976p 744991 8295338 KLTH0D08976g Lachancea thermotolerans CBS 6340 KLTH0D08976p XP_002553101.1 744374 D 559295 CDS KLTH0D08998g 255713640 8295339 745108..745761 1 NC_013080.1 weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced; KLTH0D08998p 745761 8295339 KLTH0D08998g Lachancea thermotolerans CBS 6340 KLTH0D08998p XP_002553102.1 745108 D 559295 CDS KLTH0D09020g 255713642 8295340 complement(745849..746571) 1 NC_013080.1 similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W; KLTH0D09020p 746571 8295340 KLTH0D09020g Lachancea thermotolerans CBS 6340 KLTH0D09020p XP_002553103.1 745849 R 559295 CDS KLTH0D09042g 255713644 8295341 complement(746802..748958) 1 NC_013080.1 similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters; KLTH0D09042p 748958 8295341 KLTH0D09042g Lachancea thermotolerans CBS 6340 KLTH0D09042p XP_002553104.1 746802 R 559295 CDS KLTH0D09064g 255713646 8295342 complement(749322..753683) 1 NC_013080.1 similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha- primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; KLTH0D09064p 753683 8295342 KLTH0D09064g Lachancea thermotolerans CBS 6340 KLTH0D09064p XP_002553105.1 749322 R 559295 CDS KLTH0D09086g 255713648 8295343 753982..754779 1 NC_013080.1 similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog; KLTH0D09086p 754779 8295343 KLTH0D09086g Lachancea thermotolerans CBS 6340 KLTH0D09086p XP_002553106.1 753982 D 559295 CDS KLTH0D09108g 255713650 8295344 complement(754873..757002) 1 NC_013080.1 some similarities with uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p; KLTH0D09108p 757002 8295344 KLTH0D09108g Lachancea thermotolerans CBS 6340 KLTH0D09108p XP_002553107.1 754873 R 559295 CDS KLTH0D09130g 255713652 8295345 758342..759427 1 NC_013080.1 some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose- induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p; KLTH0D09130p 759427 8295345 KLTH0D09130g Lachancea thermotolerans CBS 6340 KLTH0D09130p XP_002553108.1 758342 D 559295 CDS KLTH0D09152g 255713654 8295346 760328..762154 1 NC_013080.1 highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2- isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway; KLTH0D09152p 762154 8295346 KLTH0D09152g Lachancea thermotolerans CBS 6340 KLTH0D09152p XP_002553109.1 760328 D 559295 CDS KLTH0D09174g 255713656 8295347 762443..765796 1 NC_013080.1 similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5- phosphatase; KLTH0D09174p 765796 8295347 KLTH0D09174g Lachancea thermotolerans CBS 6340 KLTH0D09174p XP_002553110.1 762443 D 559295 CDS KLTH0D09196g 255713658 8295348 complement(765986..766552) 1 NC_013080.1 similar to uniprot|P53930 YNL107W Saccharomyces cerevisiae YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p; KLTH0D09196p 766552 8295348 KLTH0D09196g Lachancea thermotolerans CBS 6340 KLTH0D09196p XP_002553111.1 765986 R 559295 CDS KLTH0D09218g 255713660 8295349 join(766792..766821,766859..768109) 1 NC_013080.1 similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W; KLTH0D09218p 768109 8295349 KLTH0D09218g Lachancea thermotolerans CBS 6340 KLTH0D09218p XP_002553112.1 766792 D 559295 CDS KLTH0D09240g 255713662 8295350 768379..769134 1 NC_013080.1 similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF; KLTH0D09240p 769134 8295350 KLTH0D09240g Lachancea thermotolerans CBS 6340 KLTH0D09240p XP_002553113.1 768379 D 559295 CDS KLTH0D09262g 255713664 8295351 769384..770055 1 NC_013080.1 similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm; KLTH0D09262p 770055 8295351 KLTH0D09262g Lachancea thermotolerans CBS 6340 KLTH0D09262p XP_002553114.1 769384 D 559295 CDS KLTH0D09284g 255713666 8295352 770560..770931 1 NC_013080.1 similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation; KLTH0D09284p 770931 8295352 KLTH0D09284g Lachancea thermotolerans CBS 6340 KLTH0D09284p XP_002553115.1 770560 D 559295 CDS KLTH0D09306g 255713668 8295353 771018..773357 1 NC_013080.1 similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W; KLTH0D09306p 773357 8295353 KLTH0D09306g Lachancea thermotolerans CBS 6340 KLTH0D09306p XP_002553116.1 771018 D 559295 CDS KLTH0D09328g 255713670 8295354 complement(join(773449..773837,774557..775823)) 1 NC_013080.1 similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing; KLTH0D09328p 775823 8295354 KLTH0D09328g Lachancea thermotolerans CBS 6340 KLTH0D09328p XP_002553117.1 773449 R 559295 CDS KLTH0D09350g 255713672 8295355 complement(776115..776555) 1 NC_013080.1 some similarities with uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III; KLTH0D09350p 776555 8295355 KLTH0D09350g Lachancea thermotolerans CBS 6340 KLTH0D09350p XP_002553118.1 776115 R 559295 CDS KLTH0D09372g 255713674 8295356 complement(776870..777832) 1 NC_013080.1 similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase responsible for arginine degradation expression responds to both induction by arginine and nitrogen catabolite repression disruption enhances freeze tolerance; KLTH0D09372p 777832 8295356 KLTH0D09372g Lachancea thermotolerans CBS 6340 KLTH0D09372p XP_002553119.1 776870 R 559295 CDS KLTH0D09416g 255713676 8295358 779251..780438 1 NC_013080.1 similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p; KLTH0D09416p 780438 8295358 KLTH0D09416g Lachancea thermotolerans CBS 6340 KLTH0D09416p XP_002553120.1 779251 D 559295 CDS KLTH0D09438g 255713678 8295359 780671..781825 1 NC_013080.1 similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase; KLTH0D09438p 781825 8295359 KLTH0D09438g Lachancea thermotolerans CBS 6340 KLTH0D09438p XP_002553121.1 780671 D 559295 CDS KLTH0D09482g 255713680 8295360 complement(781892..782566) 1 NC_013080.1 weakly similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 Transcription factor IIA large chain; KLTH0D09482p 782566 8295360 KLTH0D09482g Lachancea thermotolerans CBS 6340 KLTH0D09482p XP_002553122.1 781892 R 559295 CDS KLTH0D09504g 255713682 8295361 783223..785379 1 NC_013080.1 weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis component of the FEAR regulatory network which promotes Cdc14p release from the nucleolus during anaphase potential Cdc28p substrate; KLTH0D09504p 785379 8295361 KLTH0D09504g Lachancea thermotolerans CBS 6340 KLTH0D09504p XP_002553123.1 783223 D 559295 CDS KLTH0D09526g 255713684 8295362 785720..788815 1 NC_013080.1 similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization targets the essential Rho-GTPase Cdc42p which controls establishment and maintenance of cell polarity including bud-site assembly; KLTH0D09526p 788815 8295362 KLTH0D09526g Lachancea thermotolerans CBS 6340 KLTH0D09526p XP_002553124.1 785720 D 559295 CDS KLTH0D09548g 255713686 8295363 complement(788915..790030) 1 NC_013080.1 highly similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C; KLTH0D09548p 790030 8295363 KLTH0D09548g Lachancea thermotolerans CBS 6340 KLTH0D09548p XP_002553125.1 788915 R 559295 CDS KLTH0D09570g 255713688 8295364 complement(790606..790833) 1 NC_013080.1 conserved hypothetical protein; KLTH0D09570p 790833 8295364 KLTH0D09570g Lachancea thermotolerans CBS 6340 KLTH0D09570p XP_002553126.1 790606 R 559295 CDS KLTH0D09592g 255713690 8295365 complement(792708..794825) 1 NC_013080.1 similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); KLTH0D09592p 794825 8295365 KLTH0D09592g Lachancea thermotolerans CBS 6340 KLTH0D09592p XP_002553127.1 792708 R 559295 CDS KLTH0D09614g 255713692 8295366 795668..796975 1 NC_013080.1 highly similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases; KLTH0D09614p 796975 8295366 KLTH0D09614g Lachancea thermotolerans CBS 6340 KLTH0D09614p XP_002553128.1 795668 D 559295 CDS KLTH0D09636g 255713694 8295367 complement(797064..798479) 1 NC_013080.1 similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes implicated in secretion and nuclear segregation multicopy suppressor of BFA (Brefeldin A) sensitivity; KLTH0D09636p 798479 8295367 KLTH0D09636g Lachancea thermotolerans CBS 6340 KLTH0D09636p XP_002553129.1 797064 R 559295 CDS KLTH0D09658g 255713696 8295368 799938..800768 1 NC_013080.1 similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) catalyzes an essential activation step in the isoprenoid biosynthetic pathway required for viability; KLTH0D09658p 800768 8295368 KLTH0D09658g Lachancea thermotolerans CBS 6340 KLTH0D09658p XP_002553130.1 799938 D 559295 CDS KLTH0D09680g 255713698 8295369 complement(800841..802022) 1 NC_013080.1 similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical conserved nucleotide in mitochondrial 21S rRNA; KLTH0D09680p 802022 8295369 KLTH0D09680g Lachancea thermotolerans CBS 6340 KLTH0D09680p XP_002553131.1 800841 R 559295 CDS KLTH0D09702g 255713700 8295370 802180..802863 1 NC_013080.1 highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphate dehydratase catalyzes the sixth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control via Gcn4p; KLTH0D09702p 802863 8295370 KLTH0D09702g Lachancea thermotolerans CBS 6340 KLTH0D09702p XP_002553132.1 802180 D 559295 CDS KLTH0D09724g 255713702 8295371 complement(802972..804027) 1 NC_013080.1 similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the large subunit MRP51; KLTH0D09724p 804027 8295371 KLTH0D09724g Lachancea thermotolerans CBS 6340 KLTH0D09724p XP_002553133.1 802972 R 559295 CDS KLTH0D09746g 255713704 8295372 805863..807728 1 NC_013080.1 similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala- Asp)-box RNA helicase required for translation initiation of all yeast mRNAs mutations in human DEAD-box DBY are a frequent cause of male infertility; KLTH0D09746p 807728 8295372 KLTH0D09746g Lachancea thermotolerans CBS 6340 KLTH0D09746p XP_002553134.1 805863 D 559295 CDS KLTH0D09790g 255713706 8295374 complement(808930..810450) 1 NC_013080.1 similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C; KLTH0D09790p 810450 8295374 KLTH0D09790g Lachancea thermotolerans CBS 6340 KLTH0D09790p XP_002553135.1 808930 R 559295 CDS KLTH0D09812g 255713708 8295375 810820..814254 1 NC_013080.1 highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III which is responsible for the transcription of tRNA and 5S RNA genes and other low molecular weight RNAs; KLTH0D09812p 814254 8295375 KLTH0D09812g Lachancea thermotolerans CBS 6340 KLTH0D09812p XP_002553136.1 810820 D 559295 CDS KLTH0D09834g 255713710 8295376 complement(814355..815002) 1 NC_013080.1 similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1- dependent meiotic recombination forms heterodimer with Sae3p proposed to be an assembly factor for Dmc1p; KLTH0D09834p 815002 8295376 KLTH0D09834g Lachancea thermotolerans CBS 6340 KLTH0D09834p XP_002553137.1 814355 R 559295 CDS KLTH0D09856g 255713712 8295377 complement(815253..817409) 1 NC_013080.1 similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre- ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre- ribosomes both complexes mediate intranuclear transport of ribosomal precursors; KLTH0D09856p 817409 8295377 KLTH0D09856g Lachancea thermotolerans CBS 6340 KLTH0D09856p XP_002553138.1 815253 R 559295 CDS KLTH0D09878g 255713714 8295378 817653..819260 1 NC_013080.1 similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria; KLTH0D09878p 819260 8295378 KLTH0D09878g Lachancea thermotolerans CBS 6340 KLTH0D09878p XP_002553139.1 817653 D 559295 CDS KLTH0D09900g 255713716 8295379 819367..820740 1 NC_013080.1 similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Protein required for sorting and delivery of soluble hydrolases to the vacuole; KLTH0D09900p 820740 8295379 KLTH0D09900g Lachancea thermotolerans CBS 6340 KLTH0D09900p XP_002553140.1 819367 D 559295 CDS KLTH0D09922g 255713718 8295380 820901..823504 1 NC_013080.1 highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; KLTH0D09922p 823504 8295380 KLTH0D09922g Lachancea thermotolerans CBS 6340 KLTH0D09922p XP_002553141.1 820901 D 559295 CDS KLTH0D09944g 255713720 8295381 823988..825292 1 NC_013080.1 similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases; KLTH0D09944p 825292 8295381 KLTH0D09944g Lachancea thermotolerans CBS 6340 KLTH0D09944p XP_002553142.1 823988 D 559295 CDS KLTH0D09966g 255713722 8295382 complement(825335..825985) 1 NC_013080.1 conserved hypothetical protein; KLTH0D09966p 825985 8295382 KLTH0D09966g Lachancea thermotolerans CBS 6340 KLTH0D09966p XP_002553143.1 825335 R 559295 CDS KLTH0D09988g 255713724 8295383 827667..830237 1 NC_013080.1 similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen- activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus; KLTH0D09988p 830237 8295383 KLTH0D09988g Lachancea thermotolerans CBS 6340 KLTH0D09988p XP_002553144.1 827667 D 559295 CDS KLTH0D10010g 255713726 8295384 complement(830376..833480) 1 NC_013080.1 similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits; KLTH0D10010p 833480 8295384 KLTH0D10010g Lachancea thermotolerans CBS 6340 KLTH0D10010p XP_002553145.1 830376 R 559295 CDS KLTH0D10032g 255713728 8295385 complement(833709..834998) 1 NC_013080.1 highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase; KLTH0D10032p 834998 8295385 KLTH0D10032g Lachancea thermotolerans CBS 6340 KLTH0D10032p XP_002553146.1 833709 R 559295 CDS KLTH0D10054g 255713730 8295386 complement(835206..837818) 1 NC_013080.1 similar to uniprot|Q02931 YPL126W Saccharomyces cerevisiae NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3; KLTH0D10054p 837818 8295386 KLTH0D10054g Lachancea thermotolerans CBS 6340 KLTH0D10054p XP_002553147.1 835206 R 559295 CDS KLTH0D10076g 255713732 8295387 838105..838317 1 NC_013080.1 highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III; KLTH0D10076p 838317 8295387 KLTH0D10076g Lachancea thermotolerans CBS 6340 KLTH0D10076p XP_002553148.1 838105 D 559295 CDS KLTH0D10098g 255713734 8295388 complement(838429..841023) 1 NC_013080.1 similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p; KLTH0D10098p 841023 8295388 KLTH0D10098g Lachancea thermotolerans CBS 6340 KLTH0D10098p XP_002553149.1 838429 R 559295 CDS KLTH0D10120g 255713736 8295389 join(841691..841859,841922..842379) 1 NC_013080.1 similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1, a linker histone required for nucleosome packaging at sites; KLTH0D10120p 842379 8295389 KLTH0D10120g Lachancea thermotolerans CBS 6340 KLTH0D10120p XP_002553150.1 841691 D 559295 CDS KLTH0D10164g 255713738 8295390 843374..844915 1 NC_013080.1 some similarities with uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor; KLTH0D10164p 844915 8295390 KLTH0D10164g Lachancea thermotolerans CBS 6340 KLTH0D10164p XP_002553151.1 843374 D 559295 CDS KLTH0D10186g 255713740 8295391 845352..846617 1 NC_013080.1 similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit; KLTH0D10186p 846617 8295391 KLTH0D10186g Lachancea thermotolerans CBS 6340 KLTH0D10186p XP_002553152.1 845352 D 559295 CDS KLTH0D10208g 255713742 8295392 complement(join(846664..847317,847390..847398)) 1 NC_013080.1 weakly similar to uniprot|Q99314 Saccharomyces cerevisiae YOR213C SAS5 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity; KLTH0D10208p 847398 8295392 KLTH0D10208g Lachancea thermotolerans CBS 6340 KLTH0D10208p XP_002553153.1 846664 R 559295 CDS KLTH0D10230g 255713744 8295393 complement(join(847624..848367,848452..848460)) 1 NC_013080.1 highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain; KLTH0D10230p 848460 8295393 KLTH0D10230g Lachancea thermotolerans CBS 6340 KLTH0D10230p XP_002553154.1 847624 R 559295 CDS KLTH0D10252g 255713746 8295394 complement(848849..849412) 1 NC_013080.1 similar to uniprot|Q12032 YOR215C Saccharomyces cerevisiae Hypothetical ORF; KLTH0D10252p 849412 8295394 KLTH0D10252g Lachancea thermotolerans CBS 6340 KLTH0D10252p XP_002553155.1 848849 R 559295 CDS KLTH0D10274g 255713748 8295395 complement(849747..851162) 1 NC_013080.1 similar to uniprot|Q12234 YOR216C Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi; KLTH0D10274p 851162 8295395 KLTH0D10274g Lachancea thermotolerans CBS 6340 KLTH0D10274p XP_002553156.1 849747 R 559295 CDS KLTH0D10296g 255713750 8295396 851319..853913 1 NC_013080.1 similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; KLTH0D10296p 853913 8295396 KLTH0D10296g Lachancea thermotolerans CBS 6340 KLTH0D10296p XP_002553157.1 851319 D 559295 CDS KLTH0D10318g 255713752 8295397 complement(853996..856611) 1 NC_013080.1 similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a- factor; KLTH0D10318p 856611 8295397 KLTH0D10318g Lachancea thermotolerans CBS 6340 KLTH0D10318p XP_002553158.1 853996 R 559295 CDS KLTH0D10340g 255713754 8295398 complement(856900..857787) 1 NC_013080.1 highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit; KLTH0D10340p 857787 8295398 KLTH0D10340g Lachancea thermotolerans CBS 6340 KLTH0D10340p XP_002553159.1 856900 R 559295 CDS KLTH0D10362g 255713756 8295399 complement(858224..858952) 1 NC_013080.1 no similarity; KLTH0D10362p 858952 8295399 KLTH0D10362g Lachancea thermotolerans CBS 6340 KLTH0D10362p XP_002553160.1 858224 R 559295 CDS KLTH0D10384g 255713758 8295400 859289..859933 1 NC_013080.1 weakly similar to uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF; KLTH0D10384p 859933 8295400 KLTH0D10384g Lachancea thermotolerans CBS 6340 KLTH0D10384p XP_002553161.1 859289 D 559295 CDS KLTH0D10406g 255713760 8295401 complement(860078..860842) 1 NC_013080.1 similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase; KLTH0D10406p 860842 8295401 KLTH0D10406g Lachancea thermotolerans CBS 6340 KLTH0D10406p XP_002553162.1 860078 R 559295 CDS KLTH0D10428g 255713762 8295402 861135..862196 1 NC_013080.1 similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator; KLTH0D10428p 862196 8295402 KLTH0D10428g Lachancea thermotolerans CBS 6340 KLTH0D10428p XP_002553163.1 861135 D 559295 CDS KLTH0D10450g 255713764 8295403 complement(862180..863160) 1 NC_013080.1 weakly similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling; KLTH0D10450p 863160 8295403 KLTH0D10450g Lachancea thermotolerans CBS 6340 KLTH0D10450p XP_002553164.1 862180 R 559295 CDS KLTH0D10472g 255713766 8295404 863427..864317 1 NC_013080.1 similar to uniprot|Q99297 Saccharomyces cerevisiae YOR222W ODC2 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; KLTH0D10472p 864317 8295404 KLTH0D10472g Lachancea thermotolerans CBS 6340 KLTH0D10472p XP_002553165.1 863427 D 559295 CDS KLTH0D10494g 255713768 8295405 864837..865595 1 NC_013080.1 similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF; KLTH0D10494p 865595 8295405 KLTH0D10494g Lachancea thermotolerans CBS 6340 KLTH0D10494p XP_002553166.1 864837 D 559295 CDS KLTH0D10516g 255713770 8295406 complement(865650..866273) 1 NC_013080.1 conserved hypothetical protein; KLTH0D10516p 866273 8295406 KLTH0D10516g Lachancea thermotolerans CBS 6340 KLTH0D10516p XP_002553167.1 865650 R 559295 CDS KLTH0D10538g 255713772 8295407 complement(866502..866936) 1 NC_013080.1 highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III; KLTH0D10538p 866936 8295407 KLTH0D10538g Lachancea thermotolerans CBS 6340 KLTH0D10538p XP_002553168.1 866502 R 559295 CDS KLTH0D10560g 255713774 8295408 complement(867215..867742) 1 NC_013080.1 highly similar to uniprot|Q12056 Saccharomyces cerevisiae YOR226C ISU2 Conserved protein of the mitochondrial matrix required for synthesis of mitochondrial and cytosolic iron-sulfur proteins; KLTH0D10560p 867742 8295408 KLTH0D10560g Lachancea thermotolerans CBS 6340 KLTH0D10560p XP_002553169.1 867215 R 559295 CDS KLTH0D10582g 255713776 8295409 869369..872800 1 NC_013080.1 similar to uniprot|Q12276 Saccharomyces cerevisiae YOR227W Hypothetical ORF; KLTH0D10582p 872800 8295409 KLTH0D10582g Lachancea thermotolerans CBS 6340 KLTH0D10582p XP_002553170.1 869369 D 559295 CDS KLTH0D10604g 255713778 8295410 complement(873026..873877) 1 NC_013080.1 weakly similar to uniprot|Q12106 Saccharomyces cerevisiae YOR228C Hypothetical ORF; KLTH0D10604p 873877 8295410 KLTH0D10604g Lachancea thermotolerans CBS 6340 KLTH0D10604p XP_002553171.1 873026 R 559295 CDS KLTH0D10626g 255713780 8295411 874019..875023 1 NC_013080.1 similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C; KLTH0D10626p 875023 8295411 KLTH0D10626g Lachancea thermotolerans CBS 6340 KLTH0D10626p XP_002553172.1 874019 D 559295 CDS KLTH0D10648g 255713782 8295412 join(875331..875337,875409..876751) 1 NC_013080.1 weakly similar to uniprot|Q12206 YOR229W Saccharomyces cerevisiae WTM2 WD repeat containing transcriptional modulator 2; KLTH0D10648p 876751 8295412 KLTH0D10648g Lachancea thermotolerans CBS 6340 KLTH0D10648p XP_002553173.1 875331 D 559295 CDS KLTH0D10670g 255713784 8295413 877472..878806 1 NC_013080.1 some similarities with uniprot|P32490 Saccharomyces cerevisiae YOR231W MKK1 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk2p; KLTH0D10670p 878806 8295413 KLTH0D10670g Lachancea thermotolerans CBS 6340 KLTH0D10670p XP_002553174.1 877472 D 559295 CDS KLTH0D10692g 255713786 8295414 879032..879748 1 NC_013080.1 similar to uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria; KLTH0D10692p 879748 8295414 KLTH0D10692g Lachancea thermotolerans CBS 6340 KLTH0D10692p XP_002553175.1 879032 D 559295 CDS KLTH0D10714g 255713788 8295415 880389..883007 1 NC_013080.1 similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C Hypothetical ORF; KLTH0D10714p 883007 8295415 KLTH0D10714g Lachancea thermotolerans CBS 6340 KLTH0D10714p XP_002553176.1 880389 D 559295 CDS KLTH0D10736g 255713790 8295416 complement(join(883254..883558,883936..883954)) 1 NC_013080.1 highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W, RPL33A Ribosomal Protein of the Large subunit; KLTH0D10736p 883954 8295416 KLTH0D10736g Lachancea thermotolerans CBS 6340 KLTH0D10736p XP_002553177.1 883254 R 559295 CDS KLTH0D10780g 255713792 8295749 complement(885342..885728) 1 NC_013080.1 conserved hypothetical protein; KLTH0D10780p 885728 8295749 KLTH0D10780g Lachancea thermotolerans CBS 6340 KLTH0D10780p XP_002553178.1 885342 R 559295 CDS KLTH0D10802g 255713794 8295418 885955..886668 1 NC_013080.1 similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function; KLTH0D10802p 886668 8295418 KLTH0D10802g Lachancea thermotolerans CBS 6340 KLTH0D10802p XP_002553179.1 885955 D 559295 CDS KLTH0D10824g 255713796 8295419 887004..888257 1 NC_013080.1 similar to uniprot|P35844 Saccharomyces cerevisiae YPL145C KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions peripheral membrane protein that localizes to the Golgi complex; KLTH0D10824p 888257 8295419 KLTH0D10824g Lachancea thermotolerans CBS 6340 KLTH0D10824p XP_002553180.1 887004 D 559295 CDS KLTH0D10846g 255713798 8295420 888656..890002 1 NC_013080.1 similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired; KLTH0D10846p 890002 8295420 KLTH0D10846g Lachancea thermotolerans CBS 6340 KLTH0D10846p XP_002553181.1 888656 D 559295 CDS KLTH0D10868g 255713800 8295421 890134..891021 1 NC_013080.1 similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Hypothetical ORF; KLTH0D10868p 891021 8295421 KLTH0D10868g Lachancea thermotolerans CBS 6340 KLTH0D10868p XP_002553182.1 890134 D 559295 CDS KLTH0D10890g 255713802 8295422 complement(891012..893504) 1 NC_013080.1 similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter; KLTH0D10890p 893504 8295422 KLTH0D10890g Lachancea thermotolerans CBS 6340 KLTH0D10890p XP_002553183.1 891012 R 559295 CDS KLTH0D10912g 255713804 8295423 894176..895039 1 NC_013080.1 conserved hypothetical protein; KLTH0D10912p 895039 8295423 KLTH0D10912g Lachancea thermotolerans CBS 6340 KLTH0D10912p XP_002553184.1 894176 D 559295 CDS KLTH0D10934g 255713806 8295424 895142..895927 1 NC_013080.1 conserved hypothetical protein; KLTH0D10934p 895927 8295424 KLTH0D10934g Lachancea thermotolerans CBS 6340 KLTH0D10934p XP_002553185.1 895142 D 559295 CDS KLTH0D10956g 255713808 8295425 896070..896660 1 NC_013080.1 similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation; KLTH0D10956p 896660 8295425 KLTH0D10956g Lachancea thermotolerans CBS 6340 KLTH0D10956p XP_002553186.1 896070 D 559295 CDS KLTH0D11000g 255713810 8295427 complement(898726..899616) 1 NC_013080.1 similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation; KLTH0D11000p 899616 8295427 KLTH0D11000g Lachancea thermotolerans CBS 6340 KLTH0D11000p XP_002553187.1 898726 R 559295 CDS KLTH0D11022g 255713812 8295428 899665..901266 1 NC_013080.1 conserved hypothetical protein; KLTH0D11022p 901266 8295428 KLTH0D11022g Lachancea thermotolerans CBS 6340 KLTH0D11022p XP_002553188.1 899665 D 559295 CDS KLTH0D11044g 255713814 8295429 complement(901388..903937) 1 NC_013080.1 similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W; KLTH0D11044p 903937 8295429 KLTH0D11044g Lachancea thermotolerans CBS 6340 KLTH0D11044p XP_002553189.1 901388 R 559295 CDS KLTH0D11066g 255713816 8295430 904878..906359 1 NC_013080.1 similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria; KLTH0D11066p 906359 8295430 KLTH0D11066g Lachancea thermotolerans CBS 6340 KLTH0D11066p XP_002553190.1 904878 D 559295 CDS KLTH0D11088g 255713818 8295431 complement(906439..907707) 1 NC_013080.1 some similarities with uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation; KLTH0D11088p 907707 8295431 KLTH0D11088g Lachancea thermotolerans CBS 6340 KLTH0D11088p XP_002553191.1 906439 R 559295 CDS KLTH0D11110g 255713820 8295432 complement(907970..910036) 1 NC_013080.1 similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35; KLTH0D11110p 910036 8295432 KLTH0D11110g Lachancea thermotolerans CBS 6340 KLTH0D11110p XP_002553192.1 907970 R 559295 CDS KLTH0D11132g 255713822 8295433 910259..911572 1 NC_013080.1 similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome; KLTH0D11132p 911572 8295433 KLTH0D11132g Lachancea thermotolerans CBS 6340 KLTH0D11132p XP_002553193.1 910259 D 559295 CDS KLTH0D11154g 255713824 8295434 911708..913045 1 NC_013080.1 highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression; KLTH0D11154p 913045 8295434 KLTH0D11154g Lachancea thermotolerans CBS 6340 KLTH0D11154p XP_002553194.1 911708 D 559295 CDS KLTH0D11176g 255713826 8295435 complement(913077..914138) 1 NC_013080.1 similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Resistant to Rapamycin; KLTH0D11176p 914138 8295435 KLTH0D11176g Lachancea thermotolerans CBS 6340 KLTH0D11176p XP_002553195.1 913077 R 559295 CDS KLTH0D11198g 255713828 8295436 complement(914281..915780) 1 NC_013080.1 similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles; KLTH0D11198p 915780 8295436 KLTH0D11198g Lachancea thermotolerans CBS 6340 KLTH0D11198p XP_002553196.1 914281 R 559295 CDS KLTH0D11220g 255713830 8295437 916020..918002 1 NC_013080.1 weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; KLTH0D11220p 918002 8295437 KLTH0D11220g Lachancea thermotolerans CBS 6340 KLTH0D11220p XP_002553197.1 916020 D 559295 CDS KLTH0D11242g 255713832 8295438 918232..920619 1 NC_013080.1 similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; KLTH0D11242p 920619 8295438 KLTH0D11242g Lachancea thermotolerans CBS 6340 KLTH0D11242p XP_002553198.1 918232 D 559295 CDS KLTH0D11264g 255713834 8295439 920981..922234 1 NC_013080.1 highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates; KLTH0D11264p 922234 8295439 KLTH0D11264g Lachancea thermotolerans CBS 6340 KLTH0D11264p XP_002553199.1 920981 D 559295 CDS KLTH0D11286g 255713836 8295440 922942..924978 1 NC_013080.1 similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning; KLTH0D11286p 924978 8295440 KLTH0D11286g Lachancea thermotolerans CBS 6340 KLTH0D11286p XP_002553200.1 922942 D 559295 CDS KLTH0D11308g 255713838 8295441 925622..926437 1 NC_013080.1 some similarities with uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein predicted to have 1 transmembrane segment transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift; KLTH0D11308p 926437 8295441 KLTH0D11308g Lachancea thermotolerans CBS 6340 KLTH0D11308p XP_002553201.1 925622 D 559295 CDS KLTH0D11330g 255713840 8295442 complement(926504..927412) 1 NC_013080.1 similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase; KLTH0D11330p 927412 8295442 KLTH0D11330g Lachancea thermotolerans CBS 6340 KLTH0D11330p XP_002553202.1 926504 R 559295 CDS KLTH0D11352g 255713842 8295443 927949..929754 1 NC_013080.1 weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF; KLTH0D11352p 929754 8295443 KLTH0D11352g Lachancea thermotolerans CBS 6340 KLTH0D11352p XP_002553203.1 927949 D 559295 CDS KLTH0D11374g 255713844 8295444 complement(929788..931119) 1 NC_013080.1 similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF and weakly similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YBR177c uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase, may be involved in lipid metabolism, null mutant slightly temperature sensitive at 37C; KLTH0D11374p 931119 8295444 KLTH0D11374g Lachancea thermotolerans CBS 6340 KLTH0D11374p XP_002553204.1 929788 R 559295 CDS KLTH0D11396g 255713846 8295445 931339..932016 1 NC_013080.1 similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome; KLTH0D11396p 932016 8295445 KLTH0D11396g Lachancea thermotolerans CBS 6340 KLTH0D11396p XP_002553205.1 931339 D 559295 CDS KLTH0D11418g 255713848 8295446 complement(932256..932531) 1 NC_013080.1 conserved hypothetical protein; KLTH0D11418p 932531 8295446 KLTH0D11418g Lachancea thermotolerans CBS 6340 KLTH0D11418p XP_002553206.1 932256 R 559295 CDS KLTH0D11440g 255713850 8295447 complement(932979..936275) 1 NC_013080.1 highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA; KLTH0D11440p 936275 8295447 KLTH0D11440g Lachancea thermotolerans CBS 6340 KLTH0D11440p XP_002553207.1 932979 R 559295 CDS KLTH0D11462g 255713852 8295448 complement(938262..939236) 1 NC_013080.1 similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases; KLTH0D11462p 939236 8295448 KLTH0D11462g Lachancea thermotolerans CBS 6340 KLTH0D11462p XP_002553208.1 938262 R 559295 CDS KLTH0D11484g 255713854 8295449 941011..942834 1 NC_013080.1 similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; KLTH0D11484p 942834 8295449 KLTH0D11484g Lachancea thermotolerans CBS 6340 KLTH0D11484p XP_002553209.1 941011 D 559295 CDS KLTH0D11506g 255713856 8295450 942952..943761 1 NC_013080.1 similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C; KLTH0D11506p 943761 8295450 KLTH0D11506g Lachancea thermotolerans CBS 6340 KLTH0D11506p XP_002553210.1 942952 D 559295 CDS KLTH0D11528g 255713858 8295451 944475..945056 1 NC_013080.1 conserved hypothetical protein; KLTH0D11528p 945056 8295451 KLTH0D11528g Lachancea thermotolerans CBS 6340 KLTH0D11528p XP_002553211.1 944475 D 559295 CDS KLTH0D11550g 255713860 8295452 945401..947494 1 NC_013080.1 similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability; KLTH0D11550p 947494 8295452 KLTH0D11550g Lachancea thermotolerans CBS 6340 KLTH0D11550p XP_002553212.1 945401 D 559295 CDS KLTH0D11572g 255713862 8295453 complement(947503..949554) 1 NC_013080.1 weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0D11572p 949554 8295453 KLTH0D11572g Lachancea thermotolerans CBS 6340 KLTH0D11572p XP_002553213.1 947503 R 559295 CDS KLTH0D11594g 255713864 8295454 complement(949719..951041) 1 NC_013080.1 similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit; KLTH0D11594p 951041 8295454 KLTH0D11594g Lachancea thermotolerans CBS 6340 KLTH0D11594p XP_002553214.1 949719 R 559295 CDS KLTH0D11616g 255713866 8295455 complement(951182..952090) 1 NC_013080.1 similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate; KLTH0D11616p 952090 8295455 KLTH0D11616g Lachancea thermotolerans CBS 6340 KLTH0D11616p XP_002553215.1 951182 R 559295 CDS KLTH0D11638g 255713868 8295456 952307..953368 1 NC_013080.1 similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6; KLTH0D11638p 953368 8295456 KLTH0D11638g Lachancea thermotolerans CBS 6340 KLTH0D11638p XP_002553216.1 952307 D 559295 CDS KLTH0D11660g 255713870 8295457 complement(953365..953880) 1 NC_013080.1 some similarities with uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0D11660p 953880 8295457 KLTH0D11660g Lachancea thermotolerans CBS 6340 KLTH0D11660p XP_002553217.1 953365 R 559295 CDS KLTH0D11682g 255713872 8295458 953995..958497 1 NC_013080.1 similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage; KLTH0D11682p 958497 8295458 KLTH0D11682g Lachancea thermotolerans CBS 6340 KLTH0D11682p XP_002553218.1 953995 D 559295 CDS KLTH0D11704g 255713874 8295459 958658..959227 1 NC_013080.1 highly similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF; KLTH0D11704p 959227 8295459 KLTH0D11704g Lachancea thermotolerans CBS 6340 KLTH0D11704p XP_002553219.1 958658 D 559295 CDS KLTH0D11726g 255713876 8295460 complement(959234..960448) 1 NC_013080.1 some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W; KLTH0D11726p 960448 8295460 KLTH0D11726g Lachancea thermotolerans CBS 6340 KLTH0D11726p XP_002553220.1 959234 R 559295 CDS KLTH0D11748g 255713878 8295461 960571..961059 1 NC_013080.1 similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing; KLTH0D11748p 961059 8295461 KLTH0D11748g Lachancea thermotolerans CBS 6340 KLTH0D11748p XP_002553221.1 960571 D 559295 CDS KLTH0D11770g 255713880 8295462 complement(961180..963138) 1 NC_013080.1 similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post- translational SRP-independent protein targeting and import into the ER; KLTH0D11770p 963138 8295462 KLTH0D11770g Lachancea thermotolerans CBS 6340 KLTH0D11770p XP_002553222.1 961180 R 559295 CDS KLTH0D11792g 255713882 8295463 963412..965235 1 NC_013080.1 similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP; KLTH0D11792p 965235 8295463 KLTH0D11792g Lachancea thermotolerans CBS 6340 KLTH0D11792p XP_002553223.1 963412 D 559295 CDS KLTH0D11814g 255713884 8295464 965505..966515 1 NC_013080.1 weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers; KLTH0D11814p 966515 8295464 KLTH0D11814g Lachancea thermotolerans CBS 6340 KLTH0D11814p XP_002553224.1 965505 D 559295 CDS KLTH0D11836g 255713886 8295465 complement(966612..967064) 1 NC_013080.1 highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis; KLTH0D11836p 967064 8295465 KLTH0D11836g Lachancea thermotolerans CBS 6340 KLTH0D11836p XP_002553225.1 966612 R 559295 CDS KLTH0D11858g 255713888 8295466 complement(967344..969698) 1 NC_013080.1 similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C; KLTH0D11858p 969698 8295466 KLTH0D11858g Lachancea thermotolerans CBS 6340 KLTH0D11858p XP_002553226.1 967344 R 559295 CDS KLTH0D11880g 255713890 8295467 969889..971202 1 NC_013080.1 similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis mutations cause defects in transcription and in biogenesis of cell wall proteins; KLTH0D11880p 971202 8295467 KLTH0D11880g Lachancea thermotolerans CBS 6340 KLTH0D11880p XP_002553227.1 969889 D 559295 CDS KLTH0D11902g 255713892 8295468 complement(971208..973667) 1 NC_013080.1 weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued); KLTH0D11902p 973667 8295468 KLTH0D11902g Lachancea thermotolerans CBS 6340 KLTH0D11902p XP_002553228.1 971208 R 559295 CDS KLTH0D11924g 255713894 8295469 973790..974320 1 NC_013080.1 highly similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p; KLTH0D11924p 974320 8295469 KLTH0D11924g Lachancea thermotolerans CBS 6340 KLTH0D11924p XP_002553229.1 973790 D 559295 CDS KLTH0D11946g 255713896 8295470 974554..975435 1 NC_013080.1 similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit; KLTH0D11946p 975435 8295470 KLTH0D11946g Lachancea thermotolerans CBS 6340 KLTH0D11946p XP_002553230.1 974554 D 559295 CDS KLTH0D11968g 255713898 8295471 975613..976254 1 NC_013080.1 similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; KLTH0D11968p 976254 8295471 KLTH0D11968g Lachancea thermotolerans CBS 6340 KLTH0D11968p XP_002553231.1 975613 D 559295 CDS KLTH0D11990g 255713900 8295472 complement(976271..977572) 1 NC_013080.1 highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle; KLTH0D11990p 977572 8295472 KLTH0D11990g Lachancea thermotolerans CBS 6340 KLTH0D11990p XP_002553232.1 976271 R 559295 CDS KLTH0D12012g 255713902 8295473 977828..979327 1 NC_013080.1 similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; KLTH0D12012p 979327 8295473 KLTH0D12012g Lachancea thermotolerans CBS 6340 KLTH0D12012p XP_002553233.1 977828 D 559295 CDS KLTH0D12034g 255713904 8295474 complement(979433..980761) 1 NC_013080.1 similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders; KLTH0D12034p 980761 8295474 KLTH0D12034g Lachancea thermotolerans CBS 6340 KLTH0D12034p XP_002553234.1 979433 R 559295 CDS KLTH0D12056g 255713906 8295475 complement(980947..982059) 1 NC_013080.1 highly similar to uniprot|Q6Q5I7 Saccharomyces cerevisiae YOR261C; KLTH0D12056p 982059 8295475 KLTH0D12056g Lachancea thermotolerans CBS 6340 KLTH0D12056p XP_002553235.1 980947 R 559295 CDS KLTH0D12078g 255713908 8295476 982337..983380 1 NC_013080.1 highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability; KLTH0D12078p 983380 8295476 KLTH0D12078g Lachancea thermotolerans CBS 6340 KLTH0D12078p XP_002553236.1 982337 D 559295 CDS KLTH0D12100g 255713910 8295477 983742..984959 1 NC_013080.1 weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate; KLTH0D12100p 984959 8295477 KLTH0D12100g Lachancea thermotolerans CBS 6340 KLTH0D12100p XP_002553237.1 983742 D 559295 CDS KLTH0D12122g 255713912 8295478 985213..985536 1 NC_013080.1 similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta- tubulin; KLTH0D12122p 985536 8295478 KLTH0D12122g Lachancea thermotolerans CBS 6340 KLTH0D12122p XP_002553238.1 985213 D 559295 CDS KLTH0D12144g 255713914 8295479 985993..987219 1 NC_013080.1 weakly similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein; KLTH0D12144p 987219 8295479 KLTH0D12144g Lachancea thermotolerans CBS 6340 KLTH0D12144p XP_002553239.1 985993 D 559295 CDS KLTH0D12166g 255713916 8295480 complement(987310..989061) 1 NC_013080.1 similar to uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H( )-ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis; KLTH0D12166p 989061 8295480 KLTH0D12166g Lachancea thermotolerans CBS 6340 KLTH0D12166p XP_002553240.1 987310 R 559295 CDS KLTH0D12188g 255713918 8295481 990209..991582 1 NC_013080.1 similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1; KLTH0D12188p 991582 8295481 KLTH0D12188g Lachancea thermotolerans CBS 6340 KLTH0D12188p XP_002553241.1 990209 D 559295 CDS KLTH0D12210g 255713920 8295482 complement(991654..994116) 1 NC_013080.1 similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V- ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; KLTH0D12210p 994116 8295482 KLTH0D12210g Lachancea thermotolerans CBS 6340 KLTH0D12210p XP_002553242.1 991654 R 559295 CDS KLTH0D12232g 255713922 8295483 994890..996137 1 NC_013080.1 similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate; KLTH0D12232p 996137 8295483 KLTH0D12232g Lachancea thermotolerans CBS 6340 KLTH0D12232p XP_002553243.1 994890 D 559295 CDS KLTH0D12254g 255713924 8295484 complement(996251..997234) 1 NC_013080.1 highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF; KLTH0D12254p 997234 8295484 KLTH0D12254g Lachancea thermotolerans CBS 6340 KLTH0D12254p XP_002553244.1 996251 R 559295 CDS KLTH0D12276g 255713926 8295485 998921..1000258 1 NC_013080.1 highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein; KLTH0D12276p 1000258 8295485 KLTH0D12276g Lachancea thermotolerans CBS 6340 KLTH0D12276p XP_002553245.1 998921 D 559295 CDS KLTH0D12298g 255713928 8295486 complement(1000588..1001883) 1 NC_013080.1 similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF; KLTH0D12298p 1001883 8295486 KLTH0D12298g Lachancea thermotolerans CBS 6340 KLTH0D12298p XP_002553246.1 1000588 R 559295 CDS KLTH0D12320g 255713930 8295487 complement(1001954..1003720) 1 NC_013080.1 similar to uniprot|Q12256 Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein; KLTH0D12320p 1003720 8295487 KLTH0D12320g Lachancea thermotolerans CBS 6340 KLTH0D12320p XP_002553247.1 1001954 R 559295 CDS KLTH0D12364g 255713932 8295488 1008585..1009985 1 NC_013080.1 similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W; KLTH0D12364p 1009985 8295488 KLTH0D12364g Lachancea thermotolerans CBS 6340 KLTH0D12364p XP_002553248.1 1008585 D 559295 CDS KLTH0D12386g 255713934 8295489 1010092..1011402 1 NC_013080.1 similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms; KLTH0D12386p 1011402 8295489 KLTH0D12386g Lachancea thermotolerans CBS 6340 KLTH0D12386p XP_002553249.1 1010092 D 559295 CDS KLTH0D12408g 255713936 8295490 complement(1011408..1013390) 1 NC_013080.1 similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation; KLTH0D12408p 1013390 8295490 KLTH0D12408g Lachancea thermotolerans CBS 6340 KLTH0D12408p XP_002553250.1 1011408 R 559295 CDS KLTH0D12430g 255713938 8295491 complement(1015264..1017444) 1 NC_013080.1 similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0D12430p 1017444 8295491 KLTH0D12430g Lachancea thermotolerans CBS 6340 KLTH0D12430p XP_002553251.1 1015264 R 559295 CDS KLTH0D12452g 255713940 8295492 1017570..1019261 1 NC_013080.1 similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N- terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p; KLTH0D12452p 1019261 8295492 KLTH0D12452g Lachancea thermotolerans CBS 6340 KLTH0D12452p XP_002553252.1 1017570 D 559295 CDS KLTH0D12474g 255713942 8295493 1019454..1019915 1 NC_013080.1 similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap- binding complex involved in translational control repressor of cap- dependent translation initiation competes with eIF4G for binding to eIF4E; KLTH0D12474p 1019915 8295493 KLTH0D12474g Lachancea thermotolerans CBS 6340 KLTH0D12474p XP_002553253.1 1019454 D 559295 CDS KLTH0D12496g 255713944 8295494 1020286..1021413 1 NC_013080.1 similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog; KLTH0D12496p 1021413 8295494 KLTH0D12496g Lachancea thermotolerans CBS 6340 KLTH0D12496p XP_002553254.1 1020286 D 559295 CDS KLTH0D12518g 255713946 8295495 complement(1023214..1024992) 1 NC_013080.1 similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C; KLTH0D12518p 1024992 8295495 KLTH0D12518g Lachancea thermotolerans CBS 6340 KLTH0D12518p XP_002553255.1 1023214 R 559295 CDS KLTH0D12540g 255713948 8295496 complement(join(1025489..1026407,1026476..1026555)) 1 NC_013080.1 conserved hypothetical protein; KLTH0D12540p 1026555 8295496 KLTH0D12540g Lachancea thermotolerans CBS 6340 KLTH0D12540p XP_002553256.1 1025489 R 559295 CDS KLTH0D12562g 255713950 8295497 1028139..1028522 1 NC_013080.1 conserved hypothetical protein; KLTH0D12562p 1028522 8295497 KLTH0D12562g Lachancea thermotolerans CBS 6340 KLTH0D12562p XP_002553257.1 1028139 D 559295 CDS KLTH0D12584g 255713952 8295498 1028809..1030386 1 NC_013080.1 highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; KLTH0D12584p 1030386 8295498 KLTH0D12584g Lachancea thermotolerans CBS 6340 KLTH0D12584p XP_002553258.1 1028809 D 559295 CDS KLTH0D12606g 255713954 8295499 1030537..1031310 1 NC_013080.1 similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway; KLTH0D12606p 1031310 8295499 KLTH0D12606g Lachancea thermotolerans CBS 6340 KLTH0D12606p XP_002553259.1 1030537 D 559295 CDS KLTH0D12628g 255713956 8295500 complement(1031332..1034637) 1 NC_013080.1 similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; KLTH0D12628p 1034637 8295500 KLTH0D12628g Lachancea thermotolerans CBS 6340 KLTH0D12628p XP_002553260.1 1031332 R 559295 CDS KLTH0D12650g 255713958 8295501 1034776..1038984 1 NC_013080.1 conserved hypothetical protein; KLTH0D12650p 1038984 8295501 KLTH0D12650g Lachancea thermotolerans CBS 6340 KLTH0D12650p XP_002553261.1 1034776 D 559295 CDS KLTH0D12672g 255713960 8295502 1039205..1040542 1 NC_013080.1 similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate; KLTH0D12672p 1040542 8295502 KLTH0D12672g Lachancea thermotolerans CBS 6340 KLTH0D12672p XP_002553262.1 1039205 D 559295 CDS KLTH0D12694g 255713962 8295503 complement(1040606..1041595) 1 NC_013080.1 weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; KLTH0D12694p 1041595 8295503 KLTH0D12694g Lachancea thermotolerans CBS 6340 KLTH0D12694p XP_002553263.1 1040606 R 559295 CDS KLTH0D12716g 255713964 8295504 complement(1041826..1043394) 1 NC_013080.1 similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria; KLTH0D12716p 1043394 8295504 KLTH0D12716g Lachancea thermotolerans CBS 6340 KLTH0D12716p XP_002553264.1 1041826 R 559295 CDS KLTH0D12738g 255713966 8295505 complement(1044169..1044936) 1 NC_013080.1 similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C or uniprot|Q99369 Saccharomyces cerevisiae YOR280C FSH3 Serine hydrolase; KLTH0D12738p 1044936 8295505 KLTH0D12738g Lachancea thermotolerans CBS 6340 KLTH0D12738p XP_002553265.1 1044169 R 559295 CDS KLTH0D12760g 255713968 8295506 1045108..1046469 1 NC_013080.1 similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5- Acetyltransferase) acetylation complex required for SAGA- mediated deubiquitination of histone H2B; KLTH0D12760p 1046469 8295506 KLTH0D12760g Lachancea thermotolerans CBS 6340 KLTH0D12760p XP_002553266.1 1045108 D 559295 CDS KLTH0D12782g 255713970 8295507 complement(1046554..1047363) 1 NC_013080.1 similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C; KLTH0D12782p 1047363 8295507 KLTH0D12782g Lachancea thermotolerans CBS 6340 KLTH0D12782p XP_002553267.1 1046554 R 559295 CDS KLTH0D12804g 255713972 8295508 complement(1047503..1049497) 1 NC_013080.1 similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double- strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved; KLTH0D12804p 1049497 8295508 KLTH0D12804g Lachancea thermotolerans CBS 6340 KLTH0D12804p XP_002553268.1 1047503 R 559295 CDS KLTH0D12826g 255713974 8295509 1049629..1050321 1 NC_013080.1 similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W; KLTH0D12826p 1050321 8295509 KLTH0D12826g Lachancea thermotolerans CBS 6340 KLTH0D12826p XP_002553269.1 1049629 D 559295 CDS KLTH0D12848g 255713976 8295510 1050528..1050983 1 NC_013080.1 similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W; KLTH0D12848p 1050983 8295510 KLTH0D12848g Lachancea thermotolerans CBS 6340 KLTH0D12848p XP_002553270.1 1050528 D 559295 CDS KLTH0D12870g 255713978 8295511 1051199..1051615 1 NC_013080.1 similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF; KLTH0D12870p 1051615 8295511 KLTH0D12870g Lachancea thermotolerans CBS 6340 KLTH0D12870p XP_002553271.1 1051199 D 559295 CDS KLTH0D12892g 255713980 8295512 complement(1051723..1052676) 1 NC_013080.1 weakly similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability; KLTH0D12892p 1052676 8295512 KLTH0D12892g Lachancea thermotolerans CBS 6340 KLTH0D12892p XP_002553272.1 1051723 R 559295 CDS KLTH0D12914g 255713982 8295513 complement(join(1052987..1053225,1053291..1053348)) 1 NC_013080.1 similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit; KLTH0D12914p 1053348 8295513 KLTH0D12914g Lachancea thermotolerans CBS 6340 KLTH0D12914p XP_002553273.1 1052987 R 559295 CDS KLTH0D12936g 255713984 8295514 complement(1053567..1054502) 1 NC_013080.1 similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family overexpression suppresses the defect in maturation of carboxypeptidase Y and defects in other essential Pdi1p functions caused by PDI1 deletion; KLTH0D12936p 1054502 8295514 KLTH0D12936g Lachancea thermotolerans CBS 6340 KLTH0D12936p XP_002553274.1 1053567 R 559295 CDS KLTH0D12958g 255713986 8295515 1055009..1055707 1 NC_013080.1 similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF; KLTH0D12958p 1055707 8295515 KLTH0D12958g Lachancea thermotolerans CBS 6340 KLTH0D12958p XP_002553275.1 1055009 D 559295 CDS KLTH0D13002g 255713988 8295517 1056918..1057721 1 NC_013080.1 highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP( )-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids; KLTH0D13002p 1057721 8295517 KLTH0D13002g Lachancea thermotolerans CBS 6340 KLTH0D13002p XP_002553276.1 1056918 D 559295 CDS KLTH0D13046g 255713990 8295519 complement(join(1059302..1063870,1063940..1063993)) 1 NC_013080.1 similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator; KLTH0D13046p 1063993 8295519 KLTH0D13046g Lachancea thermotolerans CBS 6340 KLTH0D13046p XP_002553277.1 1059302 R 559295 CDS KLTH0D13068g 255713992 8295520 1064214..1064765 1 NC_013080.1 conserved hypothetical protein; KLTH0D13068p 1064765 8295520 KLTH0D13068g Lachancea thermotolerans CBS 6340 KLTH0D13068p XP_002553278.1 1064214 D 559295 CDS KLTH0D13090g 255713994 8295521 complement(1064767..1066431) 1 NC_013080.1 some similarities with uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation; KLTH0D13090p 1066431 8295521 KLTH0D13090g Lachancea thermotolerans CBS 6340 KLTH0D13090p XP_002553279.1 1064767 R 559295 CDS KLTH0D13112g 255713996 8295522 1066575..1067600 1 NC_013080.1 similar to uniprot|P14908 Saccharomyces cerevisiae YMR228W MTF1 Mitochondrial RNA polymerase sigma- like specificity factor required for promoter recognition interacts with mitochondrial core polymerase Rpo41p imported into mitochondria via a novel process requiring most of the Mtf1p sequence; KLTH0D13112p 1067600 8295522 KLTH0D13112g Lachancea thermotolerans CBS 6340 KLTH0D13112p XP_002553280.1 1066575 D 559295 CDS KLTH0D13134g 255713998 8295523 complement(1067675..1068859) 1 NC_013080.1 conserved hypothetical protein; KLTH0D13134p 1068859 8295523 KLTH0D13134g Lachancea thermotolerans CBS 6340 KLTH0D13134p XP_002553281.1 1067675 R 559295 CDS KLTH0D13156g 255714000 8295524 complement(1069076..1074271) 1 NC_013080.1 similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs; KLTH0D13156p 1074271 8295524 KLTH0D13156g Lachancea thermotolerans CBS 6340 KLTH0D13156p XP_002553282.1 1069076 R 559295 CDS KLTH0D13178g 255714002 8295525 1075300..1079718 1 NC_013080.1 similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W Hypothetical ORF; KLTH0D13178p 1079718 8295525 KLTH0D13178g Lachancea thermotolerans CBS 6340 KLTH0D13178p XP_002553283.1 1075300 D 559295 CDS KLTH0D13200g 255714004 8295526 complement(1079736..1080695) 1 NC_013080.1 similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Hypothetical ORF; KLTH0D13200p 1080695 8295526 KLTH0D13200g Lachancea thermotolerans CBS 6340 KLTH0D13200p XP_002553284.1 1079736 R 559295 CDS KLTH0D13222g 255714006 8295527 join(1081064..1081115,1081471..1081739) 1 NC_013080.1 highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit; KLTH0D13222p 1081739 8295527 KLTH0D13222g Lachancea thermotolerans CBS 6340 KLTH0D13222p XP_002553285.1 1081064 D 559295 CDS KLTH0D13244g 255714008 8295528 1082204..1083139 1 NC_013080.1 some similarities with uniprot|P53238 Saccharomyces cerevisiae YGR058W Hypothetical ORF; KLTH0D13244p 1083139 8295528 KLTH0D13244g Lachancea thermotolerans CBS 6340 KLTH0D13244p XP_002553286.1 1082204 D 559295 CDS KLTH0D13288g 255714010 8295750 complement(1083849..1084529) 1 NC_013080.1 similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway; KLTH0D13288p 1084529 8295750 KLTH0D13288g Lachancea thermotolerans CBS 6340 KLTH0D13288p XP_002553287.1 1083849 R 559295 CDS KLTH0D13310g 255714012 8295530 1085898..1086827 1 NC_013080.1 highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol; KLTH0D13310p 1086827 8295530 KLTH0D13310g Lachancea thermotolerans CBS 6340 KLTH0D13310p XP_002553288.1 1085898 D 559295 CDS KLTH0D13332g 255714014 8295531 complement(1087058..1091104) 1 NC_013080.1 highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; KLTH0D13332p 1091104 8295531 KLTH0D13332g Lachancea thermotolerans CBS 6340 KLTH0D13332p XP_002553289.1 1087058 R 559295 CDS KLTH0D13354g 255714016 8295532 1091847..1092107 1 NC_013080.1 similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Hypothetical ORF; KLTH0D13354p 1092107 8295532 KLTH0D13354g Lachancea thermotolerans CBS 6340 KLTH0D13354p XP_002553290.1 1091847 D 559295 CDS KLTH0D13376g 255714018 8295533 complement(1092178..1093146) 1 NC_013080.1 similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C; KLTH0D13376p 1093146 8295533 KLTH0D13376g Lachancea thermotolerans CBS 6340 KLTH0D13376p XP_002553291.1 1092178 R 559295 CDS KLTH0D13398g 255714020 8295534 complement(1093331..1093636) 1 NC_013080.1 highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation and plays a role in pre-mRNA processing in addition Spt4p is involved in kinetochore function and gene silencing; KLTH0D13398p 1093636 8295534 KLTH0D13398g Lachancea thermotolerans CBS 6340 KLTH0D13398p XP_002553292.1 1093331 R 559295 CDS KLTH0D13420g 255714022 8295535 1093844..1094173 1 NC_013080.1 similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W Hypothetical ORF; KLTH0D13420p 1094173 8295535 KLTH0D13420g Lachancea thermotolerans CBS 6340 KLTH0D13420p XP_002553293.1 1093844 D 559295 CDS KLTH0D13442g 255714024 8295536 complement(1094195..1095973) 1 NC_013080.1 similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter; KLTH0D13442p 1095973 8295536 KLTH0D13442g Lachancea thermotolerans CBS 6340 KLTH0D13442p XP_002553294.1 1094195 R 559295 CDS KLTH0D13464g 255714026 8295537 join(1097521..1097653,1097963..1098222) 1 NC_013080.1 highly similar to uniprot|Q3E7Y3 Saccharomyces cerevisiae YLR367w RPS22B or uniprot|P0C0W1 Saccharomyces cerevisiae YJL190c RPS22A; KLTH0D13464p 1098222 8295537 KLTH0D13464g Lachancea thermotolerans CBS 6340 KLTH0D13464p XP_002553295.1 1097521 D 559295 CDS KLTH0D13486g 255714028 8295538 complement(1098555..1100516) 1 NC_013080.1 similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C Hypothetical ORF; KLTH0D13486p 1100516 8295538 KLTH0D13486g Lachancea thermotolerans CBS 6340 KLTH0D13486p XP_002553296.1 1098555 R 559295 CDS KLTH0D13508g 255714030 8295539 1100702..1102474 1 NC_013080.1 weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 Protein involved in determination of mitochondrial structure; KLTH0D13508p 1102474 8295539 KLTH0D13508g Lachancea thermotolerans CBS 6340 KLTH0D13508p XP_002553297.1 1100702 D 559295 CDS KLTH0D13530g 255714032 8295540 1102632..1104602 1 NC_013080.1 highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins; KLTH0D13530p 1104602 8295540 KLTH0D13530g Lachancea thermotolerans CBS 6340 KLTH0D13530p XP_002553298.1 1102632 D 559295 CDS KLTH0D13552g 255714034 8295541 complement(join(1104697..1105221,1105289..1105294)) 1 NC_013080.1 highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; KLTH0D13552p 1105294 8295541 KLTH0D13552g Lachancea thermotolerans CBS 6340 KLTH0D13552p XP_002553299.1 1104697 R 559295 CDS KLTH0D13574g 255714036 8295542 1105704..1109438 1 NC_013080.1 similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP; KLTH0D13574p 1109438 8295542 KLTH0D13574g Lachancea thermotolerans CBS 6340 KLTH0D13574p XP_002553300.1 1105704 D 559295 CDS KLTH0D13596g 255714038 8295543 1109701..1110741 1 NC_013080.1 similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26- carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis; KLTH0D13596p 1110741 8295543 KLTH0D13596g Lachancea thermotolerans CBS 6340 KLTH0D13596p XP_002553301.1 1109701 D 559295 CDS KLTH0D13618g 255714040 8295544 1112089..1113333 1 NC_013080.1 similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids; KLTH0D13618p 1113333 8295544 KLTH0D13618g Lachancea thermotolerans CBS 6340 KLTH0D13618p XP_002553302.1 1112089 D 559295 CDS KLTH0D13640g 255714042 8295545 complement(1113730..1114986) 1 NC_013080.1 conserved hypothetical protein; KLTH0D13640p 1114986 8295545 KLTH0D13640g Lachancea thermotolerans CBS 6340 KLTH0D13640p XP_002553303.1 1113730 R 559295 CDS KLTH0D13662g 255714044 8295546 complement(1115459..1116190) 1 NC_013080.1 no similarity; KLTH0D13662p 1116190 8295546 KLTH0D13662g Lachancea thermotolerans CBS 6340 KLTH0D13662p XP_002553304.1 1115459 R 559295 CDS KLTH0D13684g 255714046 8295547 1116541..1117332 1 NC_013080.1 weakly similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects; KLTH0D13684p 1117332 8295547 KLTH0D13684g Lachancea thermotolerans CBS 6340 KLTH0D13684p XP_002553305.1 1116541 D 559295 CDS KLTH0D13706g 255714048 8295548 complement(1117480..1118310) 1 NC_013080.1 similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein; KLTH0D13706p 1118310 8295548 KLTH0D13706g Lachancea thermotolerans CBS 6340 KLTH0D13706p XP_002553306.1 1117480 R 559295 CDS KLTH0D13728g 255714050 8295549 complement(1118518..1119066) 1 NC_013080.1 weakly similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C PSY3 Protein of unknown function deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C; KLTH0D13728p 1119066 8295549 KLTH0D13728g Lachancea thermotolerans CBS 6340 KLTH0D13728p XP_002553307.1 1118518 R 559295 CDS KLTH0D13750g 255714052 8295550 complement(1120534..1121550) 1 NC_013080.1 similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Hypothetical ORF; KLTH0D13750p 1121550 8295550 KLTH0D13750g Lachancea thermotolerans CBS 6340 KLTH0D13750p XP_002553308.1 1120534 R 559295 CDS KLTH0D13772g 255714054 8295551 1122242..1123342 1 NC_013080.1 similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase; KLTH0D13772p 1123342 8295551 KLTH0D13772g Lachancea thermotolerans CBS 6340 KLTH0D13772p XP_002553309.1 1122242 D 559295 CDS KLTH0D13794g 255714056 8295552 complement(1123440..1124486) 1 NC_013080.1 highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism; KLTH0D13794p 1124486 8295552 KLTH0D13794g Lachancea thermotolerans CBS 6340 KLTH0D13794p XP_002553310.1 1123440 R 559295 CDS KLTH0D13816g 255714058 8295553 1125469..1125930 1 NC_013080.1 some similarities with uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein; KLTH0D13816p 1125930 8295553 KLTH0D13816g Lachancea thermotolerans CBS 6340 KLTH0D13816p XP_002553311.1 1125469 D 559295 CDS KLTH0D13838g 255714060 8295554 1126128..1127501 1 NC_013080.1 similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C; KLTH0D13838p 1127501 8295554 KLTH0D13838g Lachancea thermotolerans CBS 6340 KLTH0D13838p XP_002553312.1 1126128 D 559295 CDS KLTH0D13860g 255714062 8295555 1128430..1129872 1 NC_013080.1 highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER; KLTH0D13860p 1129872 8295555 KLTH0D13860g Lachancea thermotolerans CBS 6340 KLTH0D13860p XP_002553313.1 1128430 D 559295 CDS KLTH0D13926g 255714064 8295558 1131764..1133707 1 NC_013080.1 similar to uniprot|P38196 SYBL042C Saccharomyces cerevisiae YBL042C FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport; KLTH0D13926p 1133707 8295558 KLTH0D13926g Lachancea thermotolerans CBS 6340 KLTH0D13926p XP_002553314.1 1131764 D 559295 CDS KLTH0D13948g 255714066 8295559 1134916..1136001 1 NC_013080.1 highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure; KLTH0D13948p 1136001 8295559 KLTH0D13948g Lachancea thermotolerans CBS 6340 KLTH0D13948p XP_002553315.1 1134916 D 559295 CDS KLTH0D13970g 255714068 8295560 complement(1136169..1138403) 1 NC_013080.1 similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes; KLTH0D13970p 1138403 8295560 KLTH0D13970g Lachancea thermotolerans CBS 6340 KLTH0D13970p XP_002553316.1 1136169 R 559295 CDS KLTH0D13992g 255714070 8295561 complement(1140341..1142203) 1 NC_013080.1 similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF; KLTH0D13992p 1142203 8295561 KLTH0D13992g Lachancea thermotolerans CBS 6340 KLTH0D13992p XP_002553317.1 1140341 R 559295 CDS KLTH0D14014g 255714072 8295562 1142957..1144279 1 NC_013080.1 similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance; KLTH0D14014p 1144279 8295562 KLTH0D14014g Lachancea thermotolerans CBS 6340 KLTH0D14014p XP_002553318.1 1142957 D 559295 CDS KLTH0D14036g 255714074 8295563 1144430..1146511 1 NC_013080.1 weakly similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules; KLTH0D14036p 1146511 8295563 KLTH0D14036g Lachancea thermotolerans CBS 6340 KLTH0D14036p XP_002553319.1 1144430 D 559295 CDS KLTH0D14058g 255714076 8295564 complement(1146544..1149186) 1 NC_013080.1 similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance; KLTH0D14058p 1149186 8295564 KLTH0D14058g Lachancea thermotolerans CBS 6340 KLTH0D14058p XP_002553320.1 1146544 R 559295 CDS KLTH0D14080g 255714078 8295565 1149555..1152863 1 NC_013080.1 similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination; KLTH0D14080p 1152863 8295565 KLTH0D14080g Lachancea thermotolerans CBS 6340 KLTH0D14080p XP_002553321.1 1149555 D 559295 CDS KLTH0D14102g 255714080 8295566 complement(1153018..1158156) 1 NC_013080.1 similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene; KLTH0D14102p 1158156 8295566 KLTH0D14102g Lachancea thermotolerans CBS 6340 KLTH0D14102p XP_002553322.1 1153018 R 559295 CDS KLTH0D14124g 255714082 8295567 1158426..1159067 1 NC_013080.1 similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double- strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA homologous to Rad52p; KLTH0D14124p 1159067 8295567 KLTH0D14124g Lachancea thermotolerans CBS 6340 KLTH0D14124p XP_002553323.1 1158426 D 559295 CDS KLTH0D14146g 255714084 8295568 complement(1159134..1163105) 1 NC_013080.1 similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin; KLTH0D14146p 1163105 8295568 KLTH0D14146g Lachancea thermotolerans CBS 6340 KLTH0D14146p XP_002553324.1 1159134 R 559295 CDS KLTH0D14168g 255714086 8295569 complement(1163292..1163681) 1 NC_013080.1 similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7; KLTH0D14168p 1163681 8295569 KLTH0D14168g Lachancea thermotolerans CBS 6340 KLTH0D14168p XP_002553325.1 1163292 R 559295 CDS KLTH0D14190g 255714088 8295570 join(1163719..1163745,1163907..1166477) 1 NC_013080.1 similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p; KLTH0D14190p 1166477 8295570 KLTH0D14190g Lachancea thermotolerans CBS 6340 KLTH0D14190p XP_002553326.1 1163719 D 559295 CDS KLTH0D14212g 255714090 8295571 complement(1166991..1168232) 1 NC_013080.1 similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Protein of unknown function, similar to Rei1p but not involved in bud growth; KLTH0D14212p 1168232 8295571 KLTH0D14212g Lachancea thermotolerans CBS 6340 KLTH0D14212p XP_002553327.1 1166991 R 559295 CDS KLTH0D14234g 255714092 8295572 complement(1168549..1170882) 1 NC_013080.1 similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre- rRNA in the cytoplasm associates with pre-40S ribosomal particles; KLTH0D14234p 1170882 8295572 KLTH0D14234g Lachancea thermotolerans CBS 6340 KLTH0D14234p XP_002553328.1 1168549 R 559295 CDS KLTH0D14256g 255714094 8295573 1171668..1171838 1 NC_013080.1 highly similar to uniprot|P41057 Saccharomyces cerevisiae YLR388W RPS29A and to uniprot|P41058 Saccharomyces cerevisiae YDL061C RPS29B Proteins component of the small (40S) ribosomal subunit; KLTH0D14256p 1171838 8295573 KLTH0D14256g Lachancea thermotolerans CBS 6340 KLTH0D14256p XP_002553329.1 1171668 D 559295 CDS KLTH0D14278g 255714096 8295574 complement(1172523..1175528) 1 NC_013080.1 similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family; KLTH0D14278p 1175528 8295574 KLTH0D14278g Lachancea thermotolerans CBS 6340 KLTH0D14278p XP_002553330.1 1172523 R 559295 CDS KLTH0D14300g 255714098 8295575 1175795..1176049 1 NC_013080.1 some similarities with uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Non-essential protein of unknown function; KLTH0D14300p 1176049 8295575 KLTH0D14300g Lachancea thermotolerans CBS 6340 KLTH0D14300p XP_002553331.1 1175795 D 559295 CDS KLTH0D14322g 255714100 8295576 1176834..1178687 1 NC_013080.1 similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C; KLTH0D14322p 1178687 8295576 KLTH0D14322g Lachancea thermotolerans CBS 6340 KLTH0D14322p XP_002553332.1 1176834 D 559295 CDS KLTH0D14344g 255714102 8295577 complement(join(1178849..1179284,1179376..1179413)) 1 NC_013080.1 highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC); KLTH0D14344p 1179413 8295577 KLTH0D14344g Lachancea thermotolerans CBS 6340 KLTH0D14344p XP_002553333.1 1178849 R 559295 CDS KLTH0D14366g 255714104 8295578 1179590..1180516 1 NC_013080.1 similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly- synthesized class I peroxisomal membrane proteins; KLTH0D14366p 1180516 8295578 KLTH0D14366g Lachancea thermotolerans CBS 6340 KLTH0D14366p XP_002553334.1 1179590 D 559295 CDS KLTH0D14388g 255714106 8295579 1180982..1181764 1 NC_013080.1 some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response proteins; KLTH0D14388p 1181764 8295579 KLTH0D14388g Lachancea thermotolerans CBS 6340 KLTH0D14388p XP_002553335.1 1180982 D 559295 CDS KLTH0D14410g 255714108 8295580 complement(1181928..1183178) 1 NC_013080.1 weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C Hypothetical ORF; KLTH0D14410p 1183178 8295580 KLTH0D14410g Lachancea thermotolerans CBS 6340 KLTH0D14410p XP_002553336.1 1181928 R 559295 CDS KLTH0D14432g 255714110 8295581 1183548..1184429 1 NC_013080.1 similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6; KLTH0D14432p 1184429 8295581 KLTH0D14432g Lachancea thermotolerans CBS 6340 KLTH0D14432p XP_002553337.1 1183548 D 559295 CDS KLTH0D14454g 255714112 8295582 1184533..1184763 1 NC_013080.1 conserved hypothetical protein; KLTH0D14454p 1184763 8295582 KLTH0D14454g Lachancea thermotolerans CBS 6340 KLTH0D14454p XP_002553338.1 1184533 D 559295 CDS KLTH0D14476g 255714114 8295583 complement(1184813..1186075) 1 NC_013080.1 highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha- ketoglutarate to biosynthetic processes; KLTH0D14476p 1186075 8295583 KLTH0D14476g Lachancea thermotolerans CBS 6340 KLTH0D14476p XP_002553339.1 1184813 R 559295 CDS KLTH0D14498g 255714116 8295584 complement(1186604..1186828) 1 NC_013080.1 similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; KLTH0D14498p 1186828 8295584 KLTH0D14498g Lachancea thermotolerans CBS 6340 KLTH0D14498p XP_002553340.1 1186604 R 559295 CDS KLTH0D14520g 255714118 8295585 1187204..1187386 1 NC_013080.1 highly similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; KLTH0D14520p 1187386 8295585 KLTH0D14520g Lachancea thermotolerans CBS 6340 KLTH0D14520p XP_002553341.1 1187204 D 559295 CDS KLTH0D14542g 255714120 8295586 complement(1187474..1188028) 1 NC_013080.1 similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF; KLTH0D14542p 1188028 8295586 KLTH0D14542g Lachancea thermotolerans CBS 6340 KLTH0D14542p XP_002553342.1 1187474 R 559295 CDS KLTH0D14564g 255714122 8295587 complement(1188206..1190188) 1 NC_013080.1 similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting; KLTH0D14564p 1190188 8295587 KLTH0D14564g Lachancea thermotolerans CBS 6340 KLTH0D14564p XP_002553343.1 1188206 R 559295 CDS KLTH0D14586g 255714124 8295588 complement(1190295..1192619) 1 NC_013080.1 similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs; KLTH0D14586p 1192619 8295588 KLTH0D14586g Lachancea thermotolerans CBS 6340 KLTH0D14586p XP_002553344.1 1190295 R 559295 CDS KLTH0D14608g 255714126 8295589 1192803..1193465 1 NC_013080.1 conserved hypothetical protein; KLTH0D14608p 1193465 8295589 KLTH0D14608g Lachancea thermotolerans CBS 6340 KLTH0D14608p XP_002553345.1 1192803 D 559295 CDS KLTH0D14630g 255714128 8295590 complement(1193537..1197340) 1 NC_013080.1 similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase; KLTH0D14630p 1197340 8295590 KLTH0D14630g Lachancea thermotolerans CBS 6340 KLTH0D14630p XP_002553346.1 1193537 R 559295 CDS KLTH0D14652g 255714130 8295591 complement(1198664..1200568) 1 NC_013080.1 similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p; KLTH0D14652p 1200568 8295591 KLTH0D14652g Lachancea thermotolerans CBS 6340 KLTH0D14652p XP_002553347.1 1198664 R 559295 CDS KLTH0D14674g 255714132 8295592 1201174..1202295 1 NC_013080.1 similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein; KLTH0D14674p 1202295 8295592 KLTH0D14674g Lachancea thermotolerans CBS 6340 KLTH0D14674p XP_002553348.1 1201174 D 559295 CDS KLTH0D14696g 255714134 8295593 complement(1202356..1204359) 1 NC_013080.1 similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region; KLTH0D14696p 1204359 8295593 KLTH0D14696g Lachancea thermotolerans CBS 6340 KLTH0D14696p XP_002553349.1 1202356 R 559295 CDS KLTH0D14718g 255714136 8295594 1206105..1208195 1 NC_013080.1 some similarities with uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress- responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies; KLTH0D14718p 1208195 8295594 KLTH0D14718g Lachancea thermotolerans CBS 6340 KLTH0D14718p XP_002553350.1 1206105 D 559295 CDS KLTH0D14740g 255714138 8295595 1208461..1209294 1 NC_013080.1 similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W Hypothetical ORF; KLTH0D14740p 1209294 8295595 KLTH0D14740g Lachancea thermotolerans CBS 6340 KLTH0D14740p XP_002553351.1 1208461 D 559295 CDS KLTH0D14762g 255714140 8295596 complement(1209483..1212617) 1 NC_013080.1 similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Hypothetical ORF; KLTH0D14762p 1212617 8295596 KLTH0D14762g Lachancea thermotolerans CBS 6340 KLTH0D14762p XP_002553352.1 1209483 R 559295 CDS KLTH0D14784g 255714142 8295597 1213137..1215128 1 NC_013080.1 similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain; KLTH0D14784p 1215128 8295597 KLTH0D14784g Lachancea thermotolerans CBS 6340 KLTH0D14784p XP_002553353.1 1213137 D 559295 CDS KLTH0D14806g 255714144 8295598 1215303..1216349 1 NC_013080.1 similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p; KLTH0D14806p 1216349 8295598 KLTH0D14806g Lachancea thermotolerans CBS 6340 KLTH0D14806p XP_002553354.1 1215303 D 559295 CDS KLTH0D14850g 255714146 8295752 complement(join(1217163..1217450,1217726..1217782)) 1 NC_013080.1 highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit; KLTH0D14850p 1217782 8295752 KLTH0D14850g Lachancea thermotolerans CBS 6340 KLTH0D14850p XP_002553355.1 1217163 R 559295 CDS KLTH0D14872g 255714148 8295600 1218410..1219243 1 NC_013080.1 similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Hypothetical ORF; KLTH0D14872p 1219243 8295600 KLTH0D14872g Lachancea thermotolerans CBS 6340 KLTH0D14872p XP_002553356.1 1218410 D 559295 CDS KLTH0D14894g 255714150 8295601 1219403..1220047 1 NC_013080.1 weakly similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0D14894p 1220047 8295601 KLTH0D14894g Lachancea thermotolerans CBS 6340 KLTH0D14894p XP_002553357.1 1219403 D 559295 CDS KLTH0D14916g 255714152 8295602 complement(1220229..1220558) 1 NC_013080.1 similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C Hypothetical ORF; KLTH0D14916p 1220558 8295602 KLTH0D14916g Lachancea thermotolerans CBS 6340 KLTH0D14916p XP_002553358.1 1220229 R 559295 CDS KLTH0D14938g 255714154 8295603 1220665..1223709 1 NC_013080.1 similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis; KLTH0D14938p 1223709 8295603 KLTH0D14938g Lachancea thermotolerans CBS 6340 KLTH0D14938p XP_002553359.1 1220665 D 559295 CDS KLTH0D14960g 255714156 8295604 complement(1223765..1226584) 1 NC_013080.1 highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; KLTH0D14960p 1226584 8295604 KLTH0D14960g Lachancea thermotolerans CBS 6340 KLTH0D14960p XP_002553360.1 1223765 R 559295 CDS KLTH0D14982g 255714158 8295605 1227836..1231180 1 NC_013080.1 similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; KLTH0D14982p 1231180 8295605 KLTH0D14982g Lachancea thermotolerans CBS 6340 KLTH0D14982p XP_002553361.1 1227836 D 559295 CDS KLTH0D15004g 255714160 8295606 1231550..1232284 1 NC_013080.1 similar to uniprot|Q06686 Saccharomyces cerevisiae YLR411W CTR3 High-affinity copper transporter of the plasma membrane acts as a trimer gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; KLTH0D15004p 1232284 8295606 KLTH0D15004g Lachancea thermotolerans CBS 6340 KLTH0D15004p XP_002553362.1 1231550 D 559295 CDS KLTH0D15026g 255714162 8295607 complement(1232767..1234050) 1 NC_013080.1 highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes; KLTH0D15026p 1234050 8295607 KLTH0D15026g Lachancea thermotolerans CBS 6340 KLTH0D15026p XP_002553363.1 1232767 R 559295 CDS KLTH0D15048g 255714164 8295608 1234522..1235316 1 NC_013080.1 similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W Hypothetical ORF; KLTH0D15048p 1235316 8295608 KLTH0D15048g Lachancea thermotolerans CBS 6340 KLTH0D15048p XP_002553364.1 1234522 D 559295 CDS KLTH0D15070g 255714166 8295609 complement(1235757..1241909) 1 NC_013080.1 highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities; KLTH0D15070p 1241909 8295609 KLTH0D15070g Lachancea thermotolerans CBS 6340 KLTH0D15070p XP_002553365.1 1235757 R 559295 CDS KLTH0D15092g 255714168 8295610 complement(1243549..1244463) 1 NC_013080.1 similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature; KLTH0D15092p 1244463 8295610 KLTH0D15092g Lachancea thermotolerans CBS 6340 KLTH0D15092p XP_002553366.1 1243549 R 559295 CDS KLTH0D15114g 255714170 8295611 complement(1244629..1245969) 1 NC_013080.1 similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase; KLTH0D15114p 1245969 8295611 KLTH0D15114g Lachancea thermotolerans CBS 6340 KLTH0D15114p XP_002553367.1 1244629 R 559295 CDS KLTH0D15136g 255714172 8295612 complement(1246564..1248150) 1 NC_013080.1 weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate; KLTH0D15136p 1248150 8295612 KLTH0D15136g Lachancea thermotolerans CBS 6340 KLTH0D15136p XP_002553368.1 1246564 R 559295 CDS KLTH0D15158g 255714174 8295613 1249007..1249522 1 NC_013080.1 similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA; KLTH0D15158p 1249522 8295613 KLTH0D15158g Lachancea thermotolerans CBS 6340 KLTH0D15158p XP_002553369.1 1249007 D 559295 CDS KLTH0D15180g 255714176 8295614 complement(1250309..1251151) 1 NC_013080.1 conserved hypothetical protein; KLTH0D15180p 1251151 8295614 KLTH0D15180g Lachancea thermotolerans CBS 6340 KLTH0D15180p XP_002553370.1 1250309 R 559295 CDS KLTH0D15202g 255714178 8295615 1253279..1255360 1 NC_013080.1 some similarities with uniprot|P34231 Saccharomyces cerevisiae YKL187C and some similarites with uniprot|Q06689 Saccharomyces cerevisiae YLR413W; KLTH0D15202p 1255360 8295615 KLTH0D15202g Lachancea thermotolerans CBS 6340 KLTH0D15202p XP_002553371.1 1253279 D 559295 CDS KLTH0D15224g 255714180 8295616 complement(1255547..1256338) 1 NC_013080.1 similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud; KLTH0D15224p 1256338 8295616 KLTH0D15224g Lachancea thermotolerans CBS 6340 KLTH0D15224p XP_002553372.1 1255547 R 559295 CDS KLTH0D15246g 255714182 8295617 1257193..1259589 1 NC_013080.1 similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP- binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2; KLTH0D15246p 1259589 8295617 KLTH0D15246g Lachancea thermotolerans CBS 6340 KLTH0D15246p XP_002553373.1 1257193 D 559295 CDS KLTH0D15268g 255714184 8295618 1259754..1261328 1 NC_013080.1 similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome; KLTH0D15268p 1261328 8295618 KLTH0D15268g Lachancea thermotolerans CBS 6340 KLTH0D15268p XP_002553374.1 1259754 D 559295 CDS KLTH0D15290g 255714186 8295619 complement(1261359..1262453) 1 NC_013080.1 similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response; KLTH0D15290p 1262453 8295619 KLTH0D15290g Lachancea thermotolerans CBS 6340 KLTH0D15290p XP_002553375.1 1261359 R 559295 CDS KLTH0D15334g 255714188 8295621 complement(1263836..1268098) 1 NC_013080.1 similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF; KLTH0D15334p 1268098 8295621 KLTH0D15334g Lachancea thermotolerans CBS 6340 KLTH0D15334p XP_002553376.1 1263836 R 559295 CDS KLTH0D15356g 255714190 8295622 1268302..1269411 1 NC_013080.1 similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones; KLTH0D15356p 1269411 8295622 KLTH0D15356g Lachancea thermotolerans CBS 6340 KLTH0D15356p XP_002553377.1 1268302 D 559295 CDS KLTH0D15378g 255714192 8295623 1270232..1271893 1 NC_013080.1 highly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression; KLTH0D15378p 1271893 8295623 KLTH0D15378g Lachancea thermotolerans CBS 6340 KLTH0D15378p XP_002553378.1 1270232 D 559295 CDS KLTH0D15400g 255714194 8295624 complement(join(1272038..1272513,1272584..1272635)) 1 NC_013080.1 highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase regulatory B subunit of calcineurin; KLTH0D15400p 1272635 8295624 KLTH0D15400g Lachancea thermotolerans CBS 6340 KLTH0D15400p XP_002553379.1 1272038 R 559295 CDS KLTH0D15422g 255714196 8295625 complement(1273059..1274768) 1 NC_013080.1 similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p; KLTH0D15422p 1274768 8295625 KLTH0D15422g Lachancea thermotolerans CBS 6340 KLTH0D15422p XP_002553380.1 1273059 R 559295 CDS KLTH0D15444g 255714198 8295626 1275015..1276106 1 NC_013080.1 highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase; KLTH0D15444p 1276106 8295626 KLTH0D15444g Lachancea thermotolerans CBS 6340 KLTH0D15444p XP_002553381.1 1275015 D 559295 CDS KLTH0D15466g 255714200 8295627 complement(1276185..1276580) 1 NC_013080.1 conserved hypothetical protein; KLTH0D15466p 1276580 8295627 KLTH0D15466g Lachancea thermotolerans CBS 6340 KLTH0D15466p XP_002553382.1 1276185 R 559295 CDS KLTH0D15488g 255714202 8295628 complement(1276598..1277074) 1 NC_013080.1 similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid; KLTH0D15488p 1277074 8295628 KLTH0D15488g Lachancea thermotolerans CBS 6340 KLTH0D15488p XP_002553383.1 1276598 R 559295 CDS KLTH0D15510g 255714204 8295629 1277460..1278074 1 NC_013080.1 conserved hypothetical protein; KLTH0D15510p 1278074 8295629 KLTH0D15510g Lachancea thermotolerans CBS 6340 KLTH0D15510p XP_002553384.1 1277460 D 559295 CDS KLTH0D15532g 255714206 8295630 1278546..1284365 1 NC_013080.1 similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF; KLTH0D15532p 1284365 8295630 KLTH0D15532g Lachancea thermotolerans CBS 6340 KLTH0D15532p XP_002553385.1 1278546 D 559295 CDS KLTH0D15554g 255714208 8295631 1284597..1284968 1 NC_013080.1 similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p; KLTH0D15554p 1284968 8295631 KLTH0D15554g Lachancea thermotolerans CBS 6340 KLTH0D15554p XP_002553386.1 1284597 D 559295 CDS KLTH0D15576g 255714210 8295632 1285392..1286426 1 NC_013080.1 similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase; KLTH0D15576p 1286426 8295632 KLTH0D15576g Lachancea thermotolerans CBS 6340 KLTH0D15576p XP_002553387.1 1285392 D 559295 CDS KLTH0D15620g 255714212 8295634 1288238..1289599 1 NC_013080.1 similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase; KLTH0D15620p 1289599 8295634 KLTH0D15620g Lachancea thermotolerans CBS 6340 KLTH0D15620p XP_002553388.1 1288238 D 559295 CDS KLTH0D15642g 255714214 8295635 complement(1289632..1290873) 1 NC_013080.1 similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway; KLTH0D15642p 1290873 8295635 KLTH0D15642g Lachancea thermotolerans CBS 6340 KLTH0D15642p XP_002553389.1 1289632 R 559295 CDS KLTH0D15664g 255714216 8295636 1291015..1292934 1 NC_013080.1 weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA; KLTH0D15664p 1292934 8295636 KLTH0D15664g Lachancea thermotolerans CBS 6340 KLTH0D15664p XP_002553390.1 1291015 D 559295 CDS KLTH0D15686g 255714218 8295637 complement(1293019..1293729) 1 NC_013080.1 some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins; KLTH0D15686p 1293729 8295637 KLTH0D15686g Lachancea thermotolerans CBS 6340 KLTH0D15686p XP_002553391.1 1293019 R 559295 CDS KLTH0D15708g 255714220 8295638 1294041..1294643 1 NC_013080.1 highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport; KLTH0D15708p 1294643 8295638 KLTH0D15708g Lachancea thermotolerans CBS 6340 KLTH0D15708p XP_002553392.1 1294041 D 559295 CDS KLTH0D15752g 255714222 8295640 1294994..1298956 1 NC_013080.1 similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate; KLTH0D15752p 1298956 8295640 KLTH0D15752g Lachancea thermotolerans CBS 6340 KLTH0D15752p XP_002553393.1 1294994 D 559295 CDS KLTH0D15774g 255714224 8295641 join(1299411..1299490,1299558..1300452) 1 NC_013080.1 similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF; KLTH0D15774p 1300452 8295641 KLTH0D15774g Lachancea thermotolerans CBS 6340 KLTH0D15774p XP_002553394.1 1299411 D 559295 CDS KLTH0D15796g 255714226 8295642 complement(1300503..1301009) 1 NC_013080.1 similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25; KLTH0D15796p 1301009 8295642 KLTH0D15796g Lachancea thermotolerans CBS 6340 KLTH0D15796p XP_002553395.1 1300503 R 559295 CDS KLTH0D15818g 255714228 8295643 1301287..1303125 1 NC_013080.1 similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA; KLTH0D15818p 1303125 8295643 KLTH0D15818g Lachancea thermotolerans CBS 6340 KLTH0D15818p XP_002553396.1 1301287 D 559295 CDS KLTH0D15840g 255714230 8295644 join(1305121..1305125,1305195..1307283) 1 NC_013080.1 similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; KLTH0D15840p 1307283 8295644 KLTH0D15840g Lachancea thermotolerans CBS 6340 KLTH0D15840p XP_002553397.1 1305121 D 559295 CDS KLTH0D15862g 255714232 8295645 1307620..1313892 1 NC_013080.1 similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate; KLTH0D15862p 1313892 8295645 KLTH0D15862g Lachancea thermotolerans CBS 6340 KLTH0D15862p XP_002553398.1 1307620 D 559295 CDS KLTH0D15884g 255714234 8295646 complement(1313964..1315268) 1 NC_013080.1 weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; KLTH0D15884p 1315268 8295646 KLTH0D15884g Lachancea thermotolerans CBS 6340 KLTH0D15884p XP_002553399.1 1313964 R 559295 CDS KLTH0D15906g 255714236 8295647 join(1316817..1317270,1317552..1318666) 1 NC_013080.1 highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 and to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 and to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; KLTH0D15906p 1318666 8295647 KLTH0D15906g Lachancea thermotolerans CBS 6340 KLTH0D15906p XP_002553400.1 1316817 D 559295 CDS KLTH0D15950g 255714238 8295751 complement(1318854..1320533) 1 NC_013080.1 similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein; KLTH0D15950p 1320533 8295751 KLTH0D15950g Lachancea thermotolerans CBS 6340 KLTH0D15950p XP_002553401.1 1318854 R 559295 CDS KLTH0D15972g 255714240 8295649 1320795..1321424 1 NC_013080.1 similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing; KLTH0D15972p 1321424 8295649 KLTH0D15972g Lachancea thermotolerans CBS 6340 KLTH0D15972p XP_002553402.1 1320795 D 559295 CDS KLTH0D15994g 255714242 8295650 complement(1321528..1325142) 1 NC_013080.1 weakly similar to uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function; KLTH0D15994p 1325142 8295650 KLTH0D15994g Lachancea thermotolerans CBS 6340 KLTH0D15994p XP_002553403.1 1321528 R 559295 CDS KLTH0D16016g 255714244 8295651 complement(1325519..1325905) 1 NC_013080.1 weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C Hypothetical ORF; KLTH0D16016p 1325905 8295651 KLTH0D16016g Lachancea thermotolerans CBS 6340 KLTH0D16016p XP_002553404.1 1325519 R 559295 CDS KLTH0D16038g 255714246 8295652 1326657..1327961 1 NC_013080.1 highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive; KLTH0D16038p 1327961 8295652 KLTH0D16038g Lachancea thermotolerans CBS 6340 KLTH0D16038p XP_002553405.1 1326657 D 559295 CDS KLTH0D16060g 255714248 8295653 1328913..1333556 1 NC_013080.1 similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine; KLTH0D16060p 1333556 8295653 KLTH0D16060g Lachancea thermotolerans CBS 6340 KLTH0D16060p XP_002553406.1 1328913 D 559295 CDS KLTH0D16082g 255714250 8295654 complement(1333719..1333964) 1 NC_013080.1 highly similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; KLTH0D16082p 1333964 8295654 KLTH0D16082g Lachancea thermotolerans CBS 6340 KLTH0D16082p XP_002553407.1 1333719 R 559295 CDS KLTH0D16104g 255714252 8295655 1334573..1335523 1 NC_013080.1 similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit; KLTH0D16104p 1335523 8295655 KLTH0D16104g Lachancea thermotolerans CBS 6340 KLTH0D16104p XP_002553408.1 1334573 D 559295 CDS KLTH0D16126g 255714254 8295656 complement(1335572..1336732) 1 NC_013080.1 similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA; KLTH0D16126p 1336732 8295656 KLTH0D16126g Lachancea thermotolerans CBS 6340 KLTH0D16126p XP_002553409.1 1335572 R 559295 CDS KLTH0D16148g 255714256 8295657 1336963..1339662 1 NC_013080.1 similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA; KLTH0D16148p 1339662 8295657 KLTH0D16148g Lachancea thermotolerans CBS 6340 KLTH0D16148p XP_002553410.1 1336963 D 559295 CDS KLTH0D16170g 255714258 8295658 complement(1339747..1341867) 1 NC_013080.1 similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion; KLTH0D16170p 1341867 8295658 KLTH0D16170g Lachancea thermotolerans CBS 6340 KLTH0D16170p XP_002553411.1 1339747 R 559295 CDS KLTH0D16192g 255714260 8295659 1341949..1342839 1 NC_013080.1 some similarities with uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex which is a nuclear complex comprised of Hpr1p Mft1p Rlr1p and Thp2p that is involved in transcription elongation and mitotic recombination; KLTH0D16192p 1342839 8295659 KLTH0D16192g Lachancea thermotolerans CBS 6340 KLTH0D16192p XP_002553412.1 1341949 D 559295 CDS KLTH0D16214g 255714262 8295660 complement(1342954..1343724) 1 NC_013080.1 highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit; KLTH0D16214p 1343724 8295660 KLTH0D16214g Lachancea thermotolerans CBS 6340 KLTH0D16214p XP_002553413.1 1342954 R 559295 CDS KLTH0D16236g 255714264 8295661 1344371..1345048 1 NC_013080.1 similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily; KLTH0D16236p 1345048 8295661 KLTH0D16236g Lachancea thermotolerans CBS 6340 KLTH0D16236p XP_002553414.1 1344371 D 559295 CDS KLTH0D16258g 255714266 8295662 complement(1345189..1348008) 1 NC_013080.1 similar to uniprot|P54784 Saccharomyces cerevisiae YML065W ORC1 Largest subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p; KLTH0D16258p 1348008 8295662 KLTH0D16258g Lachancea thermotolerans CBS 6340 KLTH0D16258p XP_002553415.1 1345189 R 559295 CDS KLTH0D16280g 255714268 8295663 1348298..1349506 1 NC_013080.1 similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential protein of unknown function; KLTH0D16280p 1349506 8295663 KLTH0D16280g Lachancea thermotolerans CBS 6340 KLTH0D16280p XP_002553416.1 1348298 D 559295 CDS KLTH0D16302g 255714270 8295664 1349643..1350788 1 NC_013080.1 some similarities with uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly; KLTH0D16302p 1350788 8295664 KLTH0D16302g Lachancea thermotolerans CBS 6340 KLTH0D16302p XP_002553417.1 1349643 D 559295 CDS KLTH0D16324g 255714272 8295665 join(1350920..1350950,1351049..1352040) 1 NC_013080.1 similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles; KLTH0D16324p 1352040 8295665 KLTH0D16324g Lachancea thermotolerans CBS 6340 KLTH0D16324p XP_002553418.1 1350920 D 559295 CDS KLTH0D16346g 255714274 8295666 join(1352112..1352459,1352519..1352698) 1 NC_013080.1 weakly similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF; KLTH0D16346p 1352698 8295666 KLTH0D16346g Lachancea thermotolerans CBS 6340 KLTH0D16346p XP_002553419.1 1352112 D 559295 CDS KLTH0D16368g 255714276 8295667 complement(1352805..1354199) 1 NC_013080.1 similar to uniprot|Q04638 Saccharomyces cerevisiae YML068W ITT1 Protein that modulates the efficiency of translation termination interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro contains a zinc finger domain characteristic of the TRIAD class of proteins; KLTH0D16368p 1354199 8295667 KLTH0D16368g Lachancea thermotolerans CBS 6340 KLTH0D16368p XP_002553420.1 1352805 R 559295 CDS KLTH0D16390g 255714278 8295668 complement(1354823..1356433) 1 NC_013080.1 highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation; KLTH0D16390p 1356433 8295668 KLTH0D16390g Lachancea thermotolerans CBS 6340 KLTH0D16390p XP_002553421.1 1354823 R 559295 CDS KLTH0D16412g 255714280 8295669 complement(1356664..1358424) 1 NC_013080.1 highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation; KLTH0D16412p 1358424 8295669 KLTH0D16412g Lachancea thermotolerans CBS 6340 KLTH0D16412p XP_002553422.1 1356664 R 559295 CDS KLTH0D16434g 255714282 8295670 complement(1358785..1360170) 1 NC_013080.1 conserved hypothetical protein; KLTH0D16434p 1360170 8295670 KLTH0D16434g Lachancea thermotolerans CBS 6340 KLTH0D16434p XP_002553423.1 1358785 R 559295 CDS KLTH0D16456g 255714284 8295671 complement(1360294..1362279) 1 NC_013080.1 conserved hypothetical protein; KLTH0D16456p 1362279 8295671 KLTH0D16456g Lachancea thermotolerans CBS 6340 KLTH0D16456p XP_002553424.1 1360294 R 559295 CDS KLTH0D16500g 255714286 8295673 1363767..1364273 1 NC_013080.1 conserved hypothetical protein; KLTH0D16500p 1364273 8295673 KLTH0D16500g Lachancea thermotolerans CBS 6340 KLTH0D16500p XP_002553425.1 1363767 D 559295 CDS KLTH0D16522g 255714288 8295674 1364836..1366134 1 NC_013080.1 similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Hypothetical ORF; KLTH0D16522p 1366134 8295674 KLTH0D16522g Lachancea thermotolerans CBS 6340 KLTH0D16522p XP_002553426.1 1364836 D 559295 CDS KLTH0D16544g 255714290 8295675 complement(1366262..1368142) 1 NC_013080.1 similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter; KLTH0D16544p 1368142 8295675 KLTH0D16544g Lachancea thermotolerans CBS 6340 KLTH0D16544p XP_002553427.1 1366262 R 559295 CDS KLTH0D16566g 255714292 8295676 complement(1368870..1369463) 1 NC_013080.1 conserved hypothetical protein; KLTH0D16566p 1369463 8295676 KLTH0D16566g Lachancea thermotolerans CBS 6340 KLTH0D16566p XP_002553428.1 1368870 R 559295 CDS KLTH0D16588g 255714294 8295677 1369900..1372686 1 NC_013080.1 conserved hypothetical protein; KLTH0D16588p 1372686 8295677 KLTH0D16588g Lachancea thermotolerans CBS 6340 KLTH0D16588p XP_002553429.1 1369900 D 559295 CDS KLTH0D16610g 255714296 8295678 complement(1372825..1373868) 1 NC_013080.1 highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d; KLTH0D16610p 1373868 8295678 KLTH0D16610g Lachancea thermotolerans CBS 6340 KLTH0D16610p XP_002553430.1 1372825 R 559295 CDS KLTH0D16632g 255714298 8295679 1375708..1376961 1 NC_013080.1 some similarities with uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0D16632p 1376961 8295679 KLTH0D16632g Lachancea thermotolerans CBS 6340 KLTH0D16632p XP_002553431.1 1375708 D 559295 CDS KLTH0D16654g 255714300 8295680 1377197..1381819 1 NC_013080.1 similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact; KLTH0D16654p 1381819 8295680 KLTH0D16654g Lachancea thermotolerans CBS 6340 KLTH0D16654p XP_002553432.1 1377197 D 559295 CDS KLTH0D16676g 255714302 8295681 1382021..1382353 1 NC_013080.1 conserved hypothetical protein; KLTH0D16676p 1382353 8295681 KLTH0D16676g Lachancea thermotolerans CBS 6340 KLTH0D16676p XP_002553433.1 1382021 D 559295 CDS KLTH0D16698g 255714304 8295682 join(1382375..1382389,1382654..1383169) 1 NC_013080.1 highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W; KLTH0D16698p 1383169 8295682 KLTH0D16698g Lachancea thermotolerans CBS 6340 KLTH0D16698p XP_002553434.1 1382375 D 559295 CDS KLTH0D16764g 255714306 8295684 1384207..1385466 1 NC_013080.1 highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae; KLTH0D16764p 1385466 8295684 KLTH0D16764g Lachancea thermotolerans CBS 6340 KLTH0D16764p XP_002553435.1 1384207 D 559295 CDS KLTH0D16786g 255714308 8295685 1386472..1389612 1 NC_013080.1 similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae; KLTH0D16786p 1389612 8295685 KLTH0D16786g Lachancea thermotolerans CBS 6340 KLTH0D16786p XP_002553436.1 1386472 D 559295 CDS KLTH0D16808g 255714310 8295686 complement(1389838..1390140) 1 NC_013080.1 conserved hypothetical protein; KLTH0D16808p 1390140 8295686 KLTH0D16808g Lachancea thermotolerans CBS 6340 KLTH0D16808p XP_002553437.1 1389838 R 559295 CDS KLTH0D16830g 255714312 8295687 1391560..1392045 1 NC_013080.1 no similarity; KLTH0D16830p 1392045 8295687 KLTH0D16830g Lachancea thermotolerans CBS 6340 KLTH0D16830p XP_002553438.1 1391560 D 559295 CDS KLTH0D16852g 255714314 8295688 1392572..1395007 1 NC_013080.1 similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor; KLTH0D16852p 1395007 8295688 KLTH0D16852g Lachancea thermotolerans CBS 6340 KLTH0D16852p XP_002553439.1 1392572 D 559295 CDS KLTH0D16874g 255714316 8295689 complement(join(1395056..1395498,1395555..1395591)) 1 NC_013080.1 similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi; KLTH0D16874p 1395591 8295689 KLTH0D16874g Lachancea thermotolerans CBS 6340 KLTH0D16874p XP_002553440.1 1395056 R 559295 CDS KLTH0D16896g 255714318 8295690 complement(1395711..1396916) 1 NC_013080.1 similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p; KLTH0D16896p 1396916 8295690 KLTH0D16896g Lachancea thermotolerans CBS 6340 KLTH0D16896p XP_002553441.1 1395711 R 559295 CDS KLTH0D16918g 255714320 8295691 complement(1397121..1397663) 1 NC_013080.1 highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria; KLTH0D16918p 1397663 8295691 KLTH0D16918g Lachancea thermotolerans CBS 6340 KLTH0D16918p XP_002553442.1 1397121 R 559295 CDS KLTH0D16940g 255714322 8295692 1398213..1399016 1 NC_013080.1 conserved hypothetical protein; KLTH0D16940p 1399016 8295692 KLTH0D16940g Lachancea thermotolerans CBS 6340 KLTH0D16940p XP_002553443.1 1398213 D 559295 CDS KLTH0D16962g 255714324 8295693 1399514..1401229 1 NC_013080.1 similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation; KLTH0D16962p 1401229 8295693 KLTH0D16962g Lachancea thermotolerans CBS 6340 KLTH0D16962p XP_002553444.1 1399514 D 559295 CDS KLTH0D16984g 255714326 8295694 complement(1402474..1403259) 1 NC_013080.1 similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH; KLTH0D16984p 1403259 8295694 KLTH0D16984g Lachancea thermotolerans CBS 6340 KLTH0D16984p XP_002553445.1 1402474 R 559295 CDS KLTH0D17006g 255714328 8295695 complement(1403707..1412385) 1 NC_013080.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation; KLTH0D17006p 1412385 8295695 KLTH0D17006g Lachancea thermotolerans CBS 6340 KLTH0D17006p XP_002553446.1 1403707 R 559295 CDS KLTH0D17050g 255714330 8295696 complement(1416863..1417834) 1 NC_013080.1 conserved hypothetical protein; KLTH0D17050p 1417834 8295696 KLTH0D17050g Lachancea thermotolerans CBS 6340 KLTH0D17050p XP_002553447.1 1416863 R 559295 CDS KLTH0D17072g 255714332 8295697 1418913..1419686 1 NC_013080.1 no similarity; KLTH0D17072p 1419686 8295697 KLTH0D17072g Lachancea thermotolerans CBS 6340 KLTH0D17072p XP_002553448.1 1418913 D 559295 CDS KLTH0D17094g 255714334 8295698 complement(1420060..1421244) 1 NC_013080.1 highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase; KLTH0D17094p 1421244 8295698 KLTH0D17094g Lachancea thermotolerans CBS 6340 KLTH0D17094p XP_002553449.1 1420060 R 559295 CDS KLTH0D17116g 255714336 8295699 1421622..1422263 1 NC_013080.1 similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis; KLTH0D17116p 1422263 8295699 KLTH0D17116g Lachancea thermotolerans CBS 6340 KLTH0D17116p XP_002553450.1 1421622 D 559295 CDS KLTH0D17138g 255714338 8295700 complement(1422301..1423014) 1 NC_013080.1 similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria; KLTH0D17138p 1423014 8295700 KLTH0D17138g Lachancea thermotolerans CBS 6340 KLTH0D17138p XP_002553451.1 1422301 R 559295 CDS KLTH0D17160g 255714340 8295701 1423358..1424815 1 NC_013080.1 similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5; KLTH0D17160p 1424815 8295701 KLTH0D17160g Lachancea thermotolerans CBS 6340 KLTH0D17160p XP_002553452.1 1423358 D 559295 CDS KLTH0D17182g 255714342 8295702 complement(1424948..1426342) 1 NC_013080.1 similar to uniprot|P38889 Saccharomyces cerevisiae YHR206W; KLTH0D17182p 1426342 8295702 KLTH0D17182g Lachancea thermotolerans CBS 6340 KLTH0D17182p XP_002553453.1 1424948 R 559295 CDS KLTH0D17204g 255714344 8295703 complement(1426818..1429085) 1 NC_013080.1 similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts; KLTH0D17204p 1429085 8295703 KLTH0D17204g Lachancea thermotolerans CBS 6340 KLTH0D17204p XP_002553454.1 1426818 R 559295 CDS KLTH0D17226g 255714346 8295704 complement(1430265..1432703) 1 NC_013080.1 similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides; KLTH0D17226p 1432703 8295704 KLTH0D17226g Lachancea thermotolerans CBS 6340 KLTH0D17226p XP_002553455.1 1430265 R 559295 CDS KLTH0D17248g 255714348 8295705 join(1433280..1433293,1433479..1434250) 1 NC_013080.1 highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B; KLTH0D17248p 1434250 8295705 KLTH0D17248g Lachancea thermotolerans CBS 6340 KLTH0D17248p XP_002553456.1 1433280 D 559295 CDS KLTH0D17270g 255714350 8295706 complement(1434357..1436141) 1 NC_013080.1 similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Hypothetical ORF; KLTH0D17270p 1436141 8295706 KLTH0D17270g Lachancea thermotolerans CBS 6340 KLTH0D17270p XP_002553457.1 1434357 R 559295 CDS KLTH0D17314g 255714352 8295708 complement(1436806..1437594) 1 NC_013080.1 similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance component of the mitochondrial nucleoid required for the repair of oxidative mtDNA damage; KLTH0D17314p 1437594 8295708 KLTH0D17314g Lachancea thermotolerans CBS 6340 KLTH0D17314p XP_002553458.1 1436806 R 559295 CDS KLTH0D17336g 255714354 8295709 1438527..1440800 1 NC_013080.1 similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase; KLTH0D17336p 1440800 8295709 KLTH0D17336g Lachancea thermotolerans CBS 6340 KLTH0D17336p XP_002553459.1 1438527 D 559295 CDS KLTH0D17358g 255714356 8295710 complement(1440848..1441867) 1 NC_013080.1 similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Hypothetical ORF; KLTH0D17358p 1441867 8295710 KLTH0D17358g Lachancea thermotolerans CBS 6340 KLTH0D17358p XP_002553460.1 1440848 R 559295 CDS KLTH0D17380g 255714358 8295711 1441975..1443117 1 NC_013080.1 similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix; KLTH0D17380p 1443117 8295711 KLTH0D17380g Lachancea thermotolerans CBS 6340 KLTH0D17380p XP_002553461.1 1441975 D 559295 CDS KLTH0D17402g 255714360 8295712 complement(1443112..1444170) 1 NC_013080.1 similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Protein required for cell viability; KLTH0D17402p 1444170 8295712 KLTH0D17402g Lachancea thermotolerans CBS 6340 KLTH0D17402p XP_002553462.1 1443112 R 559295 CDS KLTH0D17424g 255714362 8295713 1444277..1449196 1 NC_013080.1 similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor; KLTH0D17424p 1449196 8295713 KLTH0D17424g Lachancea thermotolerans CBS 6340 KLTH0D17424p XP_002553463.1 1444277 D 559295 CDS KLTH0D17446g 255714364 8295714 join(1449300..1449333,1449426..1450468) 1 NC_013080.1 highly similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase; KLTH0D17446p 1450468 8295714 KLTH0D17446g Lachancea thermotolerans CBS 6340 KLTH0D17446p XP_002553464.1 1449300 D 559295 CDS KLTH0D17468g 255714366 8295715 complement(1450578..1455305) 1 NC_013080.1 similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1; KLTH0D17468p 1455305 8295715 KLTH0D17468g Lachancea thermotolerans CBS 6340 KLTH0D17468p XP_002553465.1 1450578 R 559295 CDS KLTH0D17490g 255714368 8295716 complement(1455577..1456359) 1 NC_013080.1 highly similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; KLTH0D17490p 1456359 8295716 KLTH0D17490g Lachancea thermotolerans CBS 6340 KLTH0D17490p XP_002553466.1 1455577 R 559295 CDS KLTH0D17512g 255714370 8295717 1457372..1461661 1 NC_013080.1 highly similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C ECM17 Sulfite reductase beta subunit involved in amino acid biosynthesis transcription repressed by methionine; KLTH0D17512p 1461661 8295717 KLTH0D17512g Lachancea thermotolerans CBS 6340 KLTH0D17512p XP_002553467.1 1457372 D 559295 CDS KLTH0D17534g 255714372 8295718 1461841..1462758 1 NC_013080.1 some similarities with uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non- tagged protein was localized to the mitochondria; KLTH0D17534p 1462758 8295718 KLTH0D17534g Lachancea thermotolerans CBS 6340 KLTH0D17534p XP_002553468.1 1461841 D 559295 CDS KLTH0D17556g 255714374 8295719 complement(1462787..1464979) 1 NC_013080.1 conserved hypothetical protein; KLTH0D17556p 1464979 8295719 KLTH0D17556g Lachancea thermotolerans CBS 6340 KLTH0D17556p XP_002553469.1 1462787 R 559295 CDS KLTH0D17578g 255714376 8295720 1465085..1466347 1 NC_013080.1 weakly similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C Hypothetical ORF; KLTH0D17578p 1466347 8295720 KLTH0D17578g Lachancea thermotolerans CBS 6340 KLTH0D17578p XP_002553470.1 1465085 D 559295 CDS KLTH0D17600g 255714378 8295721 complement(1466390..1466653) 1 NC_013080.1 highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein; KLTH0D17600p 1466653 8295721 KLTH0D17600g Lachancea thermotolerans CBS 6340 KLTH0D17600p XP_002553471.1 1466390 R 559295 CDS KLTH0D17622g 255714380 8295722 1466847..1467524 1 NC_013080.1 weakly similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance component of the kinetochore binds to centromeric DNA in a Ctf19p-dependent manner; KLTH0D17622p 1467524 8295722 KLTH0D17622g Lachancea thermotolerans CBS 6340 KLTH0D17622p XP_002553472.1 1466847 D 559295 CDS KLTH0D17644g 255714382 8295723 complement(1467536..1469830) 1 NC_013080.1 similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein; KLTH0D17644p 1469830 8295723 KLTH0D17644g Lachancea thermotolerans CBS 6340 KLTH0D17644p XP_002553473.1 1467536 R 559295 CDS KLTH0D17688g 255714384 8295725 1470627..1472669 1 NC_013080.1 weakly similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild-type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus; KLTH0D17688p 1472669 8295725 KLTH0D17688g Lachancea thermotolerans CBS 6340 KLTH0D17688p XP_002553474.1 1470627 D 559295 CDS KLTH0D17710g 255714386 8295726 complement(1472760..1473401) 1 NC_013080.1 highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase; KLTH0D17710p 1473401 8295726 KLTH0D17710g Lachancea thermotolerans CBS 6340 KLTH0D17710p XP_002553475.1 1472760 R 559295 CDS KLTH0D17732g 255714388 8295727 complement(1473689..1475344) 1 NC_013080.1 similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0D17732p 1475344 8295727 KLTH0D17732g Lachancea thermotolerans CBS 6340 KLTH0D17732p XP_002553476.1 1473689 R 559295 CDS KLTH0D17754g 255714390 8295728 complement(1475584..1478718) 1 NC_013080.1 similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog; KLTH0D17754p 1478718 8295728 KLTH0D17754g Lachancea thermotolerans CBS 6340 KLTH0D17754p XP_002553477.1 1475584 R 559295 CDS KLTH0D17776g 255714392 8295729 complement(1478972..1479844) 1 NC_013080.1 conserved hypothetical protein; KLTH0D17776p 1479844 8295729 KLTH0D17776g Lachancea thermotolerans CBS 6340 KLTH0D17776p XP_002553478.1 1478972 R 559295 CDS KLTH0D17798g 255714394 8295730 complement(1480030..1481826) 1 NC_013080.1 highly similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology; KLTH0D17798p 1481826 8295730 KLTH0D17798g Lachancea thermotolerans CBS 6340 KLTH0D17798p XP_002553479.1 1480030 R 559295 CDS KLTH0D17842g 255714396 8295732 1482454..1482984 1 NC_013080.1 similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes; KLTH0D17842p 1482984 8295732 KLTH0D17842g Lachancea thermotolerans CBS 6340 KLTH0D17842p XP_002553480.1 1482454 D 559295 CDS KLTH0D17864g 255714398 8295733 complement(1483003..1483818) 1 NC_013080.1 similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Hypothetical ORF; KLTH0D17864p 1483818 8295733 KLTH0D17864g Lachancea thermotolerans CBS 6340 KLTH0D17864p XP_002553481.1 1483003 R 559295 CDS KLTH0D17886g 255714400 8295734 1483927..1484316 1 NC_013080.1 similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; KLTH0D17886p 1484316 8295734 KLTH0D17886g Lachancea thermotolerans CBS 6340 KLTH0D17886p XP_002553482.1 1483927 D 559295 CDS KLTH0D17908g 255714402 8295735 complement(1484372..1486003) 1 NC_013080.1 similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane; KLTH0D17908p 1486003 8295735 KLTH0D17908g Lachancea thermotolerans CBS 6340 KLTH0D17908p XP_002553483.1 1484372 R 559295 CDS KLTH0D17930g 255714404 8295736 1486259..1488217 1 NC_013080.1 similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine; KLTH0D17930p 1488217 8295736 KLTH0D17930g Lachancea thermotolerans CBS 6340 KLTH0D17930p XP_002553484.1 1486259 D 559295 CDS KLTH0D17952g 255714406 8295737 complement(1488389..1488568) 1 NC_013080.1 similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase; KLTH0D17952p 1488568 8295737 KLTH0D17952g Lachancea thermotolerans CBS 6340 KLTH0D17952p XP_002553485.1 1488389 R 559295 CDS KLTH0D17974g 255714408 8295738 1489573..1490604 1 NC_013080.1 similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; KLTH0D17974p 1490604 8295738 KLTH0D17974g Lachancea thermotolerans CBS 6340 KLTH0D17974p XP_002553486.1 1489573 D 559295 CDS KLTH0D17996g 255714410 8295739 1490856..1491809 1 NC_013080.1 similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0D17996p 1491809 8295739 KLTH0D17996g Lachancea thermotolerans CBS 6340 KLTH0D17996p XP_002553487.1 1490856 D 559295 CDS KLTH0D18018g 255714412 8295740 1492078..1492335 1 NC_013080.1 conserved hypothetical protein; KLTH0D18018p 1492335 8295740 KLTH0D18018g Lachancea thermotolerans CBS 6340 KLTH0D18018p XP_002553488.1 1492078 D 559295 CDS KLTH0D18040g 255714414 8295741 1492577..1492792 1 NC_013080.1 conserved hypothetical protein; KLTH0D18040p 1492792 8295741 KLTH0D18040g Lachancea thermotolerans CBS 6340 KLTH0D18040p XP_002553489.1 1492577 D 559295 CDS KLTH0D18062g 255714416 8295742 1493355..1496741 1 NC_013080.1 similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W Hypothetical ORF; KLTH0D18062p 1496741 8295742 KLTH0D18062g Lachancea thermotolerans CBS 6340 KLTH0D18062p XP_002553490.1 1493355 D 559295 CDS KLTH0D18084g 255714418 8295743 1496980..1498272 1 NC_013080.1 similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17; KLTH0D18084p 1498272 8295743 KLTH0D18084g Lachancea thermotolerans CBS 6340 KLTH0D18084p XP_002553491.1 1496980 D 559295 CDS KLTH0D18106g 255714420 8295744 1498428..1499093 1 NC_013080.1 similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin); KLTH0D18106p 1499093 8295744 KLTH0D18106g Lachancea thermotolerans CBS 6340 KLTH0D18106p XP_002553492.1 1498428 D 559295 CDS KLTH0D18128g 255714422 8295745 1499274..1501595 1 NC_013080.1 similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70; KLTH0D18128p 1501595 8295745 KLTH0D18128g Lachancea thermotolerans CBS 6340 KLTH0D18128p XP_002553493.1 1499274 D 559295 CDS KLTH0D18150g 255714424 8295746 complement(1502817..1504640) 1 NC_013080.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores; KLTH0D18150p 1504640 8295746 KLTH0D18150g Lachancea thermotolerans CBS 6340 KLTH0D18150p XP_002553494.1 1502817 R 559295 CDS KLTH0D18194g 255714426 8295748 1508763..1512431 1 NC_013080.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation; KLTH0D18194p 1512431 8295748 KLTH0D18194g Lachancea thermotolerans CBS 6340 KLTH0D18194p XP_002553495.1 1508763 D 559295 CDS KLTH0E00132g 255714429 8291631 3262..5010 1 NC_013081.1 weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake; KLTH0E00132p 5010 8291631 KLTH0E00132g Lachancea thermotolerans CBS 6340 KLTH0E00132p XP_002553496.1 3262 D 559295 CDS KLTH0E00154g 255714431 8291632 6352..7461 1 NC_013081.1 conserved hypothetical protein; KLTH0E00154p 7461 8291632 KLTH0E00154g Lachancea thermotolerans CBS 6340 KLTH0E00154p XP_002553497.1 6352 D 559295 CDS KLTH0E00176g 255714433 8291633 8605..10311 1 NC_013081.1 conserved hypothetical protein; KLTH0E00176p 10311 8291633 KLTH0E00176g Lachancea thermotolerans CBS 6340 KLTH0E00176p XP_002553498.1 8605 D 559295 CDS KLTH0E00198g 255714435 8291634 complement(10634..11638) 1 NC_013081.1 similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF; KLTH0E00198p 11638 8291634 KLTH0E00198g Lachancea thermotolerans CBS 6340 KLTH0E00198p XP_002553499.1 10634 R 559295 CDS KLTH0E00242g 255714437 8291635 complement(15734..19045) 1 NC_013081.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation; KLTH0E00242p 19045 8291635 KLTH0E00242g Lachancea thermotolerans CBS 6340 KLTH0E00242p XP_002553500.1 15734 R 559295 CDS KLTH0E00264g 255714439 8291636 complement(21896..23587) 1 NC_013081.1 highly similar to uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter active in early growth phase; KLTH0E00264p 23587 8291636 KLTH0E00264g Lachancea thermotolerans CBS 6340 KLTH0E00264p XP_002553501.1 21896 R 559295 CDS KLTH0E00286g 255714441 8291637 26588..27502 1 NC_013081.1 conserved hypothetical protein; KLTH0E00286p 27502 8291637 KLTH0E00286g Lachancea thermotolerans CBS 6340 KLTH0E00286p XP_002553502.1 26588 D 559295 CDS KLTH0E00308g 255714443 8291638 complement(28103..29218) 1 NC_013081.1 conserved hypothetical protein; KLTH0E00308p 29218 8291638 KLTH0E00308g Lachancea thermotolerans CBS 6340 KLTH0E00308p XP_002553503.1 28103 R 559295 CDS KLTH0E00330g 255714445 8291639 complement(30414..31385) 1 NC_013081.1 KLTH0E00330p 31385 8291639 KLTH0E00330g Lachancea thermotolerans CBS 6340 KLTH0E00330p XP_002553504.1 30414 R 559295 CDS KLTH0E00352g 255714447 8291640 33232..34779 1 NC_013081.1 KLTH0E00352p 34779 8291640 KLTH0E00352g Lachancea thermotolerans CBS 6340 KLTH0E00352p XP_002553505.1 33232 D 559295 CDS KLTH0E00374g 255714449 8291641 complement(36763..38091) 1 NC_013081.1 weakly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; KLTH0E00374p 38091 8291641 KLTH0E00374g Lachancea thermotolerans CBS 6340 KLTH0E00374p XP_002553506.1 36763 R 559295 CDS KLTH0E00418g 255714451 8291643 41913..42527 1 NC_013081.1 conserved hypothetical protein; KLTH0E00418p 42527 8291643 KLTH0E00418g Lachancea thermotolerans CBS 6340 KLTH0E00418p XP_002553507.1 41913 D 559295 CDS KLTH0E00440g 255714453 8291644 complement(42945..45011) 1 NC_013081.1 some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; KLTH0E00440p 45011 8291644 KLTH0E00440g Lachancea thermotolerans CBS 6340 KLTH0E00440p XP_002553508.1 42945 R 559295 CDS KLTH0E00462g 255714455 8291645 45358..46869 1 NC_013081.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; KLTH0E00462p 46869 8291645 KLTH0E00462g Lachancea thermotolerans CBS 6340 KLTH0E00462p XP_002553509.1 45358 D 559295 CDS KLTH0E00484g 255714457 8291646 complement(47160..50996) 1 NC_013081.1 highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF; KLTH0E00484p 50996 8291646 KLTH0E00484g Lachancea thermotolerans CBS 6340 KLTH0E00484p XP_002553510.1 47160 R 559295 CDS KLTH0E00528g 255714459 8291648 complement(54185..55843) 1 NC_013081.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs; KLTH0E00528p 55843 8291648 KLTH0E00528g Lachancea thermotolerans CBS 6340 KLTH0E00528p XP_002553511.1 54185 R 559295 CDS KLTH0E00550g 255714461 8291649 57109..58680 1 NC_013081.1 similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation; KLTH0E00550p 58680 8291649 KLTH0E00550g Lachancea thermotolerans CBS 6340 KLTH0E00550p XP_002553512.1 57109 D 559295 CDS KLTH0E00594g 255714463 8291651 complement(61565..62230) 1 NC_013081.1 similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels; KLTH0E00594p 62230 8291651 KLTH0E00594g Lachancea thermotolerans CBS 6340 KLTH0E00594p XP_002553513.1 61565 R 559295 CDS KLTH0E00616g 255714465 8291652 62596..64074 1 NC_013081.1 similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis; KLTH0E00616p 64074 8291652 KLTH0E00616g Lachancea thermotolerans CBS 6340 KLTH0E00616p XP_002553514.1 62596 D 559295 CDS KLTH0E00638g 255714467 8291653 64787..66730 1 NC_013081.1 conserved hypothetical protein; KLTH0E00638p 66730 8291653 KLTH0E00638g Lachancea thermotolerans CBS 6340 KLTH0E00638p XP_002553515.1 64787 D 559295 CDS KLTH0E00660g 255714469 8291654 67093..67770 1 NC_013081.1 weakly similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Hypothetical ORF; KLTH0E00660p 67770 8291654 KLTH0E00660g Lachancea thermotolerans CBS 6340 KLTH0E00660p XP_002553516.1 67093 D 559295 CDS KLTH0E00682g 255714471 8291655 complement(67775..68998) 1 NC_013081.1 highly similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity cleaves 3-ketoacyl-CoA into acyl- CoA and acetyl-CoA during beta-oxidation of fatty acids; KLTH0E00682p 68998 8291655 KLTH0E00682g Lachancea thermotolerans CBS 6340 KLTH0E00682p XP_002553517.1 67775 R 559295 CDS KLTH0E00704g 255714473 8291656 70073..74242 1 NC_013081.1 some similarities with uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNI1; KLTH0E00704p 74242 8291656 KLTH0E00704g Lachancea thermotolerans CBS 6340 KLTH0E00704p XP_002553518.1 70073 D 559295 CDS KLTH0E00726g 255714475 8291657 74503..75447 1 NC_013081.1 weakly similar to uniprot|P36169 Saccharomyces cerevisiae YKR100C SKG1 and weakly similar to uniprot|P40451 Saccharomyces cerevisiae YIL158w AIM20; KLTH0E00726p 75447 8291657 KLTH0E00726g Lachancea thermotolerans CBS 6340 KLTH0E00726p XP_002553519.1 74503 D 559295 CDS KLTH0E00748g 255714477 8291658 complement(75584..76132) 1 NC_013081.1 similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C FMP35 The authentic non-tagged protein was localized to the mitochondria; KLTH0E00748p 76132 8291658 KLTH0E00748g Lachancea thermotolerans CBS 6340 KLTH0E00748p XP_002553520.1 75584 R 559295 CDS KLTH0E00770g 255714479 8291659 join(76244..76252,76324..76536) 1 NC_013081.1 similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B hypothetical ORF; KLTH0E00770p 76536 8291659 KLTH0E00770g Lachancea thermotolerans CBS 6340 KLTH0E00770p XP_002553521.1 76244 D 559295 CDS KLTH0E00792g 255714481 8291660 complement(76585..78828) 1 NC_013081.1 similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; KLTH0E00792p 78828 8291660 KLTH0E00792g Lachancea thermotolerans CBS 6340 KLTH0E00792p XP_002553522.1 76585 R 559295 CDS KLTH0E00814g 255714483 8291661 80059..82983 1 NC_013081.1 similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; KLTH0E00814p 82983 8291661 KLTH0E00814g Lachancea thermotolerans CBS 6340 KLTH0E00814p XP_002553523.1 80059 D 559295 CDS KLTH0E00836g 255714485 8291662 complement(83201..85126) 1 NC_013081.1 similar to uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p Rsf1p Hap2/3/4/5 complex dependent manner; KLTH0E00836p 85126 8291662 KLTH0E00836g Lachancea thermotolerans CBS 6340 KLTH0E00836p XP_002553524.1 83201 R 559295 CDS KLTH0E00858g 255714487 8291663 complement(86253..87227) 1 NC_013081.1 some similarities with uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage; KLTH0E00858p 87227 8291663 KLTH0E00858g Lachancea thermotolerans CBS 6340 KLTH0E00858p XP_002553525.1 86253 R 559295 CDS KLTH0E00880g 255714489 8291664 87353..88468 1 NC_013081.1 similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Resistant to Rapamycin Deletion; KLTH0E00880p 88468 8291664 KLTH0E00880g Lachancea thermotolerans CBS 6340 KLTH0E00880p XP_002553526.1 87353 D 559295 CDS KLTH0E00902g 255714491 8291665 complement(88552..90186) 1 NC_013081.1 highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase key enzyme in gluconeogenesis catalyzes early reaction in carbohydrate biosynthesis glucose represses transcription and accelerates mRNA degradation regulated by Mcm1p and Cat8p located in the cytosol; KLTH0E00902p 90186 8291665 KLTH0E00902g Lachancea thermotolerans CBS 6340 KLTH0E00902p XP_002553527.1 88552 R 559295 CDS KLTH0E00924g 255714493 8291666 90490..90864 1 NC_013081.1 no similarity; KLTH0E00924p 90864 8291666 KLTH0E00924g Lachancea thermotolerans CBS 6340 KLTH0E00924p XP_002553528.1 90490 D 559295 CDS KLTH0E00946g 255714495 8291667 91205..91852 1 NC_013081.1 conserved hypothetical protein; KLTH0E00946p 91852 8291667 KLTH0E00946g Lachancea thermotolerans CBS 6340 KLTH0E00946p XP_002553529.1 91205 D 559295 CDS KLTH0E00968g 255714497 8291668 complement(92019..95465) 1 NC_013081.1 similar to uniprot|P36168 Saccharomyces cerevisiae YKR096W Hypothetical ORF; KLTH0E00968p 95465 8291668 KLTH0E00968g Lachancea thermotolerans CBS 6340 KLTH0E00968p XP_002553530.1 92019 R 559295 CDS KLTH0E00990g 255714499 8291669 complement(join(95824..96055,96120..96157)) 1 NC_013081.1 similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Protein; KLTH0E00990p 96157 8291669 KLTH0E00990g Lachancea thermotolerans CBS 6340 KLTH0E00990p XP_002553531.1 95824 R 559295 CDS KLTH0E01012g 255714501 8291670 96295..97455 1 NC_013081.1 conserved hypothetical protein; KLTH0E01012p 97455 8291670 KLTH0E01012g Lachancea thermotolerans CBS 6340 KLTH0E01012p XP_002553532.1 96295 D 559295 CDS KLTH0E01034g 255714503 8291671 complement(join(97462..99128,99197..99281)) 1 NC_013081.1 similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication; KLTH0E01034p 99281 8291671 KLTH0E01034g Lachancea thermotolerans CBS 6340 KLTH0E01034p XP_002553533.1 97462 R 559295 CDS KLTH0E01056g 255714505 8291672 complement(99471..104786) 1 NC_013081.1 similar to uniprot|Q02455 Saccharomyces cerevisiae YKR095W MLP1 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; involved in the retention of unspliced mRNAs in the nucleus; KLTH0E01056p 104786 8291672 KLTH0E01056g Lachancea thermotolerans CBS 6340 KLTH0E01056p XP_002553534.1 99471 R 559295 CDS KLTH0E01078g 255714507 8291673 join(105372..105379,105743..106121) 1 NC_013081.1 highly similar to uniprot|P61864 Saccharomyces cerevisiae YKR094c RPL40B and highly similar to uniprot|P61864 Saccharomyces cerevisiae YIL148w RPL40A; KLTH0E01078p 106121 8291673 KLTH0E01078g Lachancea thermotolerans CBS 6340 KLTH0E01078p XP_002553535.1 105372 D 559295 CDS KLTH0E01100g 255714509 8291674 complement(106377..109910) 1 NC_013081.1 similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators; KLTH0E01100p 109910 8291674 KLTH0E01100g Lachancea thermotolerans CBS 6340 KLTH0E01100p XP_002553536.1 106377 R 559295 CDS KLTH0E01122g 255714511 8291675 complement(110889..112307) 1 NC_013081.1 weakly similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ECM37 Non-essential protein of unknown function; KLTH0E01122p 112307 8291675 KLTH0E01122g Lachancea thermotolerans CBS 6340 KLTH0E01122p XP_002553537.1 110889 R 559295 CDS KLTH0E01144g 255714513 8291676 complement(113309..115027) 1 NC_013081.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W Permease that serves as a gamma- aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; KLTH0E01144p 115027 8291676 KLTH0E01144g Lachancea thermotolerans CBS 6340 KLTH0E01144p XP_002553538.1 113309 R 559295 CDS KLTH0E01166g 255714515 8291677 complement(115445..116380) 1 NC_013081.1 similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase, also known as pantoate- beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; KLTH0E01166p 116380 8291677 KLTH0E01166g Lachancea thermotolerans CBS 6340 KLTH0E01166p XP_002553539.1 115445 R 559295 CDS KLTH0E01188g 255714517 8291678 116753..118783 1 NC_013081.1 similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p- Nuf2p-Spc24p- Spc25p) conserved coiled-coil protein involved in chromosome segregation spindle checkpoint activity kinetochore assembly and clustering; KLTH0E01188p 118783 8291678 KLTH0E01188g Lachancea thermotolerans CBS 6340 KLTH0E01188p XP_002553540.1 116753 D 559295 CDS KLTH0E01210g 255714519 8291679 complement(118884..121403) 1 NC_013081.1 similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2; KLTH0E01210p 121403 8291679 KLTH0E01210g Lachancea thermotolerans CBS 6340 KLTH0E01210p XP_002553541.1 118884 R 559295 CDS KLTH0E01232g 255714521 8291680 121683..122966 1 NC_013081.1 some similarities with uniprot|P32583 Saccharomyces cerevisiae YKR092c SRP40 suppressor of mutant AC40 of RNA polymerase I and III singleton; KLTH0E01232p 122966 8291680 KLTH0E01232g Lachancea thermotolerans CBS 6340 KLTH0E01232p XP_002553542.1 121683 D 559295 CDS KLTH0E01254g 255714523 8291681 complement(123483..124442) 1 NC_013081.1 some similarities with uniprot|Q12416 Saccharomyces cerevisiae YOR083W WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division; may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF); periodically expressed in G1; KLTH0E01254p 124442 8291681 KLTH0E01254g Lachancea thermotolerans CBS 6340 KLTH0E01254p XP_002553543.1 123483 R 559295 CDS KLTH0E01276g 255714525 8291682 complement(124975..127488) 1 NC_013081.1 weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth; KLTH0E01276p 127488 8291682 KLTH0E01276g Lachancea thermotolerans CBS 6340 KLTH0E01276p XP_002553544.1 124975 R 559295 CDS KLTH0E01298g 255714527 8291683 complement(128187..129554) 1 NC_013081.1 highly similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing contains multiple transmembrane spans; KLTH0E01298p 129554 8291683 KLTH0E01298g Lachancea thermotolerans CBS 6340 KLTH0E01298p XP_002553545.1 128187 R 559295 CDS KLTH0E01320g 255714529 8291684 complement(129926..130735) 1 NC_013081.1 similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF; KLTH0E01320p 130735 8291684 KLTH0E01320g Lachancea thermotolerans CBS 6340 KLTH0E01320p XP_002553546.1 129926 R 559295 CDS KLTH0E01342g 255714531 8291685 131090..132115 1 NC_013081.1 similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 adenosine kinase; KLTH0E01342p 132115 8291685 KLTH0E01342g Lachancea thermotolerans CBS 6340 KLTH0E01342p XP_002553547.1 131090 D 559295 CDS KLTH0E01364g 255714533 8291686 132301..134319 1 NC_013081.1 weakly similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function; KLTH0E01364p 134319 8291686 KLTH0E01364g Lachancea thermotolerans CBS 6340 KLTH0E01364p XP_002553548.1 132301 D 559295 CDS KLTH0E01386g 255714535 8291687 134534..135754 1 NC_013081.1 similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF; KLTH0E01386p 135754 8291687 KLTH0E01386g Lachancea thermotolerans CBS 6340 KLTH0E01386p XP_002553549.1 134534 D 559295 CDS KLTH0E01408g 255714537 8291688 complement(136108..137460) 1 NC_013081.1 similar to uniprot|P10823 Saccharomyces cerevisiae YER020W GPA2; KLTH0E01408p 137460 8291688 KLTH0E01408g Lachancea thermotolerans CBS 6340 KLTH0E01408p XP_002553550.1 136108 R 559295 CDS KLTH0E01430g 255714539 8291689 complement(138025..138309) 1 NC_013081.1 no similarity; KLTH0E01430p 138309 8291689 KLTH0E01430g Lachancea thermotolerans CBS 6340 KLTH0E01430p XP_002553551.1 138025 R 559295 CDS KLTH0E01452g 255714541 8291690 complement(138573..141938) 1 NC_013081.1 highly similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; KLTH0E01452p 141938 8291690 KLTH0E01452g Lachancea thermotolerans CBS 6340 KLTH0E01452p XP_002553552.1 138573 R 559295 CDS KLTH0E01474g 255714543 8291691 complement(143734..144675) 1 NC_013081.1 conserved hypothetical protein; KLTH0E01474p 144675 8291691 KLTH0E01474g Lachancea thermotolerans CBS 6340 KLTH0E01474p XP_002553553.1 143734 R 559295 CDS KLTH0E01496g 255714545 8291692 complement(146000..148444) 1 NC_013081.1 similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family; KLTH0E01496p 148444 8291692 KLTH0E01496g Lachancea thermotolerans CBS 6340 KLTH0E01496p XP_002553554.1 146000 R 559295 CDS KLTH0E01518g 255714547 8291693 join(149793..149822,149900..150748) 1 NC_013081.1 highly similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17; KLTH0E01518p 150748 8291693 KLTH0E01518g Lachancea thermotolerans CBS 6340 KLTH0E01518p XP_002553555.1 149793 D 559295 CDS KLTH0E01540g 255714549 8291694 152132..154267 1 NC_013081.1 weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381w FRE3 protein Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; KLTH0E01540p 154267 8291694 KLTH0E01540g Lachancea thermotolerans CBS 6340 KLTH0E01540p XP_002553556.1 152132 D 559295 CDS KLTH0E01562g 255714551 8291695 154987..155340 1 NC_013081.1 similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1; KLTH0E01562p 155340 8291695 KLTH0E01562g Lachancea thermotolerans CBS 6340 KLTH0E01562p XP_002553557.1 154987 D 559295 CDS KLTH0E01584g 255714553 8291696 join(155974..155997,156058..158007) 1 NC_013081.1 similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate; KLTH0E01584p 158007 8291696 KLTH0E01584g Lachancea thermotolerans CBS 6340 KLTH0E01584p XP_002553558.1 155974 D 559295 CDS KLTH0E01606g 255714555 8291697 complement(158057..158872) 1 NC_013081.1 similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Hypothetical ORF; KLTH0E01606p 158872 8291697 KLTH0E01606g Lachancea thermotolerans CBS 6340 KLTH0E01606p XP_002553559.1 158057 R 559295 CDS KLTH0E01628g 255714557 8291698 159063..159671 1 NC_013081.1 similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation; KLTH0E01628p 159671 8291698 KLTH0E01628g Lachancea thermotolerans CBS 6340 KLTH0E01628p XP_002553560.1 159063 D 559295 CDS KLTH0E01650g 255714559 8291699 complement(159757..163947) 1 NC_013081.1 similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins binds membranes in a ubiquitin-dependent manner may also bind ubiquitinated membrane-associated proteins; KLTH0E01650p 163947 8291699 KLTH0E01650g Lachancea thermotolerans CBS 6340 KLTH0E01650p XP_002553561.1 159757 R 559295 CDS KLTH0E01694g 255714561 8291701 165164..165550 1 NC_013081.1 conserved hypothetical protein; KLTH0E01694p 165550 8291701 KLTH0E01694g Lachancea thermotolerans CBS 6340 KLTH0E01694p XP_002553562.1 165164 D 559295 CDS KLTH0E01716g 255714563 8291702 complement(165606..166409) 1 NC_013081.1 similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit; KLTH0E01716p 166409 8291702 KLTH0E01716g Lachancea thermotolerans CBS 6340 KLTH0E01716p XP_002553563.1 165606 R 559295 CDS KLTH0E01738g 255714565 8291703 166653..167789 1 NC_013081.1 some similarities with uniprot|P38193 Saccharomyces cerevisiae YBL046W Hypothetical ORF; KLTH0E01738p 167789 8291703 KLTH0E01738g Lachancea thermotolerans CBS 6340 KLTH0E01738p XP_002553564.1 166653 D 559295 CDS KLTH0E01760g 255714567 8291704 complement(168037..169383) 1 NC_013081.1 similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol- cytochrome c reductase complex (bc1 complex) which is a component of the mitochondrial inner membrane electron transport chain; KLTH0E01760p 169383 8291704 KLTH0E01760g Lachancea thermotolerans CBS 6340 KLTH0E01760p XP_002553565.1 168037 R 559295 CDS KLTH0E01782g 255714569 8291705 170763..171386 1 NC_013081.1 conserved hypothetical protein; KLTH0E01782p 171386 8291705 KLTH0E01782g Lachancea thermotolerans CBS 6340 KLTH0E01782p XP_002553566.1 170763 D 559295 CDS KLTH0E01804g 255714571 8291706 171881..173620 1 NC_013081.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; KLTH0E01804p 173620 8291706 KLTH0E01804g Lachancea thermotolerans CBS 6340 KLTH0E01804p XP_002553567.1 171881 D 559295 CDS KLTH0E01826g 255714573 8291707 173841..174569 1 NC_013081.1 highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 20S proteasome beta-type subunit; KLTH0E01826p 174569 8291707 KLTH0E01826g Lachancea thermotolerans CBS 6340 KLTH0E01826p XP_002553568.1 173841 D 559295 CDS KLTH0E01848g 255714575 8291708 complement(174685..175347) 1 NC_013081.1 similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins; KLTH0E01848p 175347 8291708 KLTH0E01848g Lachancea thermotolerans CBS 6340 KLTH0E01848p XP_002553569.1 174685 R 559295 CDS KLTH0E01870g 255714577 8291709 complement(175513..176523) 1 NC_013081.1 conserved hypothetical protein; KLTH0E01870p 176523 8291709 KLTH0E01870g Lachancea thermotolerans CBS 6340 KLTH0E01870p XP_002553570.1 175513 R 559295 CDS KLTH0E01892g 255714579 8291710 join(177826..177838,177910..178361) 1 NC_013081.1 highly similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cu Zn superoxide dismutase some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; KLTH0E01892p 178361 8291710 KLTH0E01892g Lachancea thermotolerans CBS 6340 KLTH0E01892p XP_002553571.1 177826 D 559295 CDS KLTH0E01914g 255714581 8291711 complement(178565..180295) 1 NC_013081.1 highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C; KLTH0E01914p 180295 8291711 KLTH0E01914g Lachancea thermotolerans CBS 6340 KLTH0E01914p XP_002553572.1 178565 R 559295 CDS KLTH0E01936g 255714583 8291712 complement(181119..181727) 1 NC_013081.1 conserved hypothetical protein; KLTH0E01936p 181727 8291712 KLTH0E01936g Lachancea thermotolerans CBS 6340 KLTH0E01936p XP_002553573.1 181119 R 559295 CDS KLTH0E01958g 255714585 8291713 181815..182357 1 NC_013081.1 similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; KLTH0E01958p 182357 8291713 KLTH0E01958g Lachancea thermotolerans CBS 6340 KLTH0E01958p XP_002553574.1 181815 D 559295 CDS KLTH0E01980g 255714587 8291714 complement(182400..183158) 1 NC_013081.1 similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit; KLTH0E01980p 183158 8291714 KLTH0E01980g Lachancea thermotolerans CBS 6340 KLTH0E01980p XP_002553575.1 182400 R 559295 CDS KLTH0E02002g 255714589 8291715 184381..185367 1 NC_013081.1 similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C Hypothetical ORF; KLTH0E02002p 185367 8291715 KLTH0E02002g Lachancea thermotolerans CBS 6340 KLTH0E02002p XP_002553576.1 184381 D 559295 CDS KLTH0E02024g 255714591 8291716 185547..186506 1 NC_013081.1 conserved hypothetical protein; KLTH0E02024p 186506 8291716 KLTH0E02024g Lachancea thermotolerans CBS 6340 KLTH0E02024p XP_002553577.1 185547 D 559295 CDS KLTH0E02046g 255714593 8291717 187098..188762 1 NC_013081.1 similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C Hypothetical ORF; KLTH0E02046p 188762 8291717 KLTH0E02046g Lachancea thermotolerans CBS 6340 KLTH0E02046p XP_002553578.1 187098 D 559295 CDS KLTH0E02068g 255714595 8291718 complement(188805..189506) 1 NC_013081.1 similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin hydrolyzes the peptide bond at the C-terminus of ubiquitin also the major processing enzyme for the ubiquitin-like protein Rub1p; KLTH0E02068p 189506 8291718 KLTH0E02068g Lachancea thermotolerans CBS 6340 KLTH0E02068p XP_002553579.1 188805 R 559295 CDS KLTH0E02090g 255714597 8291719 189685..190230 1 NC_013081.1 similar to uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP, which cleaves pre-rRNA; not shared between Rnase MRP and nuclear Rnase P, in contrast to all other Rnase MRP protein subunits; binds to the NME1 RNA subunit of Rnase MRP; KLTH0E02090p 190230 8291719 KLTH0E02090g Lachancea thermotolerans CBS 6340 KLTH0E02090p XP_002553580.1 189685 D 559295 CDS KLTH0E02112g 255714599 8291720 complement(190315..191943) 1 NC_013081.1 similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane protein, involved in regulation of peroxisome size and number; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; KLTH0E02112p 191943 8291720 KLTH0E02112g Lachancea thermotolerans CBS 6340 KLTH0E02112p XP_002553581.1 190315 R 559295 CDS KLTH0E02134g 255714601 8291721 192040..193065 1 NC_013081.1 conserved hypothetical protein; KLTH0E02134p 193065 8291721 KLTH0E02134g Lachancea thermotolerans CBS 6340 KLTH0E02134p XP_002553582.1 192040 D 559295 CDS KLTH0E02156g 255714603 8291722 complement(193083..194579) 1 NC_013081.1 similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C SET7 Nuclear protein that contains a SET-domain which have been shown to mediate methyltransferase activity in other proteins; KLTH0E02156p 194579 8291722 KLTH0E02156g Lachancea thermotolerans CBS 6340 KLTH0E02156p XP_002553583.1 193083 R 559295 CDS KLTH0E02178g 255714605 8291723 194914..196695 1 NC_013081.1 highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase; KLTH0E02178p 196695 8291723 KLTH0E02178g Lachancea thermotolerans CBS 6340 KLTH0E02178p XP_002553584.1 194914 D 559295 CDS KLTH0E02200g 255714607 8291724 complement(197021..199363) 1 NC_013081.1 highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system; KLTH0E02200p 199363 8291724 KLTH0E02200g Lachancea thermotolerans CBS 6340 KLTH0E02200p XP_002553585.1 197021 R 559295 CDS KLTH0E02222g 255714609 8291725 complement(199706..200500) 1 NC_013081.1 conserved hypothetical protein; KLTH0E02222p 200500 8291725 KLTH0E02222g Lachancea thermotolerans CBS 6340 KLTH0E02222p XP_002553586.1 199706 R 559295 CDS KLTH0E02244g 255714611 8291726 complement(200939..201328) 1 NC_013081.1 conserved hypothetical protein; KLTH0E02244p 201328 8291726 KLTH0E02244g Lachancea thermotolerans CBS 6340 KLTH0E02244p XP_002553587.1 200939 R 559295 CDS KLTH0E02310g 255714613 8291729 202124..203809 1 NC_013081.1 some similarities with uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein involved in invasive growth upon nitrogen starvation; KLTH0E02310p 203809 8291729 KLTH0E02310g Lachancea thermotolerans CBS 6340 KLTH0E02310p XP_002553588.1 202124 D 559295 CDS KLTH0E02354g 255714615 8291731 204306..205139 1 NC_013081.1 weakly similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Hypothetical ORF; KLTH0E02354p 205139 8291731 KLTH0E02354g Lachancea thermotolerans CBS 6340 KLTH0E02354p XP_002553589.1 204306 D 559295 CDS KLTH0E02376g 255714617 8291732 complement(205420..207708) 1 NC_013081.1 some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; KLTH0E02376p 207708 8291732 KLTH0E02376g Lachancea thermotolerans CBS 6340 KLTH0E02376p XP_002553590.1 205420 R 559295 CDS KLTH0E02398g 255714619 8291733 complement(209336..211333) 1 NC_013081.1 some similarities with uniprot|P39875 Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap- endonuclease involved in recombination double-strand break repair and DNA mismatch repair member of the Rad2p nuclease family with conserved N and I nuclease domains; KLTH0E02398p 211333 8291733 KLTH0E02398g Lachancea thermotolerans CBS 6340 KLTH0E02398p XP_002553591.1 209336 R 559295 CDS KLTH0E02420g 255714621 8291734 complement(211548..213752) 1 NC_013081.1 similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C AKR1 Palmitoyl transferase involved in protein palmitoylation acts as a negative regulator of pheromone response pathway required for endocytosis of pheromone receptors involved in cell shape control contains ankyrin repeats; KLTH0E02420p 213752 8291734 KLTH0E02420g Lachancea thermotolerans CBS 6340 KLTH0E02420p XP_002553592.1 211548 R 559295 CDS KLTH0E02442g 255714623 8291735 complement(213949..216135) 1 NC_013081.1 similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC- 45/CRO1/SHE4) domain binds to myosin motor domains to regulate myosin function involved in endocytosis polarization of the actin cytoskeleton and asymmetric mRNA localization; KLTH0E02442p 216135 8291735 KLTH0E02442g Lachancea thermotolerans CBS 6340 KLTH0E02442p XP_002553593.1 213949 R 559295 CDS KLTH0E02464g 255714625 8291736 join(216256..216301,216358..217301) 1 NC_013081.1 similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import interacts with Pex12p links ubiquitin-conjugating Pex4p to protein import machinery mutations in human homolog cause a variety of peroxisomal disorders; KLTH0E02464p 217301 8291736 KLTH0E02464g Lachancea thermotolerans CBS 6340 KLTH0E02464p XP_002553594.1 216256 D 559295 CDS KLTH0E02486g 255714627 8291737 complement(217352..219211) 1 NC_013081.1 similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Hypothetical ORF; KLTH0E02486p 219211 8291737 KLTH0E02486g Lachancea thermotolerans CBS 6340 KLTH0E02486p XP_002553595.1 217352 R 559295 CDS KLTH0E02508g 255714629 8291738 join(219822..220022,220088..220462) 1 NC_013081.1 similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C Hypothetical ORF; KLTH0E02508p 220462 8291738 KLTH0E02508g Lachancea thermotolerans CBS 6340 KLTH0E02508p XP_002553596.1 219822 D 559295 CDS KLTH0E02530g 255714631 8291739 complement(221189..232354) 1 NC_013081.1 similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Histone acetyltransferase component putative ortholog of human TRRAP which is an essential cofactor of c-Myc; KLTH0E02530p 232354 8291739 KLTH0E02530g Lachancea thermotolerans CBS 6340 KLTH0E02530p XP_002553597.1 221189 R 559295 CDS KLTH0E02552g 255714633 8291740 complement(233320..234822) 1 NC_013081.1 similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol; KLTH0E02552p 234822 8291740 KLTH0E02552g Lachancea thermotolerans CBS 6340 KLTH0E02552p XP_002553598.1 233320 R 559295 CDS KLTH0E02596g 255714635 8291742 235803..237593 1 NC_013081.1 weakly similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease located in the cytoplasm and endoplasmic reticulum; KLTH0E02596p 237593 8291742 KLTH0E02596g Lachancea thermotolerans CBS 6340 KLTH0E02596p XP_002553599.1 235803 D 559295 CDS KLTH0E02618g 255714637 8291743 237948..240656 1 NC_013081.1 similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Member of the Sec24p family forms a complex with Sec23p that is involved in sorting of Pma1p into COPII vesicles peripheral ER membrane protein potential Cdc28p substrate; KLTH0E02618p 240656 8291743 KLTH0E02618g Lachancea thermotolerans CBS 6340 KLTH0E02618p XP_002553600.1 237948 D 559295 CDS KLTH0E02640g 255714639 8291744 241007..241273 1 NC_013081.1 conserved hypothetical protein; KLTH0E02640p 241273 8291744 KLTH0E02640g Lachancea thermotolerans CBS 6340 KLTH0E02640p XP_002553601.1 241007 D 559295 CDS KLTH0E02662g 255714641 8291745 241639..242844 1 NC_013081.1 weakly similar to uniprot|Q66RD5 Saccharomyces cerevisiae YDR348C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck potential Cdc28p substrate; KLTH0E02662p 242844 8291745 KLTH0E02662g Lachancea thermotolerans CBS 6340 KLTH0E02662p XP_002553602.1 241639 D 559295 CDS KLTH0E02684g 255714643 8291746 complement(243196..244116) 1 NC_013081.1 similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit MRP1 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator and with PET123 encoding a small subunit mitochondrial ribosomal protein; KLTH0E02684p 244116 8291746 KLTH0E02684g Lachancea thermotolerans CBS 6340 KLTH0E02684p XP_002553603.1 243196 R 559295 CDS KLTH0E02728g 255714645 8291748 244900..246144 1 NC_013081.1 similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways required for the diauxic growth shift expression in mammalian cells increases survival under conditions inducing apoptosis; KLTH0E02728p 246144 8291748 KLTH0E02728g Lachancea thermotolerans CBS 6340 KLTH0E02728p XP_002553604.1 244900 D 559295 CDS KLTH0E02750g 255714647 8291749 248224..249927 1 NC_013081.1 highly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily expression is induced in low or high glucose conditions; KLTH0E02750p 249927 8291749 KLTH0E02750g Lachancea thermotolerans CBS 6340 KLTH0E02750p XP_002553605.1 248224 D 559295 CDS KLTH0E02772g 255714649 8291750 252118..253833 1 NC_013081.1 highly similar to uniprot|P39003 Saccharomyces cerevisiae YDR343C HXT6 High-affinity glucose transporter of the major facilitator superfamily nearly identical to Hxt7p expressed at high basal levels relative to other HXTs repression of expression by high glucose requires SNF3; KLTH0E02772p 253833 8291750 KLTH0E02772g Lachancea thermotolerans CBS 6340 KLTH0E02772p XP_002553606.1 252118 D 559295 CDS KLTH0E02794g 255714651 8291751 complement(254093..254998) 1 NC_013081.1 conserved hypothetical protein; KLTH0E02794p 254998 8291751 KLTH0E02794g Lachancea thermotolerans CBS 6340 KLTH0E02794p XP_002553607.1 254093 R 559295 CDS KLTH0E02816g 255714653 8291752 255428..257365 1 NC_013081.1 highly similar to uniprot|Q05506 Saccharomyces cerevisiae YDR341C Cytoplasmic arginyl-tRNA synthetase; KLTH0E02816p 257365 8291752 KLTH0E02816g Lachancea thermotolerans CBS 6340 KLTH0E02816p XP_002553608.1 255428 D 559295 CDS KLTH0E02860g 255714655 8291754 258370..258939 1 NC_013081.1 highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C Protein required for cell viability; KLTH0E02860p 258939 8291754 KLTH0E02860g Lachancea thermotolerans CBS 6340 KLTH0E02860p XP_002553609.1 258370 D 559295 CDS KLTH0E02882g 255714657 8291755 complement(258995..259561) 1 NC_013081.1 conserved hypothetical protein; KLTH0E02882p 259561 8291755 KLTH0E02882g Lachancea thermotolerans CBS 6340 KLTH0E02882p XP_002553610.1 258995 R 559295 CDS KLTH0E02904g 255714659 8291756 259875..260672 1 NC_013081.1 similar to uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Yeast homolog of mammalian Ing1 NuA4 histone acetyltransferase complex component; KLTH0E02904p 260672 8291756 KLTH0E02904g Lachancea thermotolerans CBS 6340 KLTH0E02904p XP_002553611.1 259875 D 559295 CDS KLTH0E02926g 255714661 8291757 260858..262939 1 NC_013081.1 similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF; KLTH0E02926p 262939 8291757 KLTH0E02926g Lachancea thermotolerans CBS 6340 KLTH0E02926p XP_002553612.1 260858 D 559295 CDS KLTH0E02948g 255714663 8291758 263206..264675 1 NC_013081.1 weakly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase; KLTH0E02948p 264675 8291758 KLTH0E02948g Lachancea thermotolerans CBS 6340 KLTH0E02948p XP_002553613.1 263206 D 559295 CDS KLTH0E02970g 255714665 8291759 complement(264820..265695) 1 NC_013081.1 similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit; KLTH0E02970p 265695 8291759 KLTH0E02970g Lachancea thermotolerans CBS 6340 KLTH0E02970p XP_002553614.1 264820 R 559295 CDS KLTH0E02992g 255714667 8291760 complement(267098..270199) 1 NC_013081.1 conserved hypothetical protein; KLTH0E02992p 270199 8291760 KLTH0E02992g Lachancea thermotolerans CBS 6340 KLTH0E02992p XP_002553615.1 267098 R 559295 CDS KLTH0E03014g 255714669 8291761 270908..271543 1 NC_013081.1 some similarities with uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex involved in the modification and cleavage of the 18S pre-rRNA; KLTH0E03014p 271543 8291761 KLTH0E03014g Lachancea thermotolerans CBS 6340 KLTH0E03014p XP_002553616.1 270908 D 559295 CDS KLTH0E03036g 255714671 8291762 complement(271665..272726) 1 NC_013081.1 similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Hypothetical ORF; KLTH0E03036p 272726 8291762 KLTH0E03036g Lachancea thermotolerans CBS 6340 KLTH0E03036p XP_002553617.1 271665 R 559295 CDS KLTH0E03058g 255714673 8291763 complement(272968..276630) 1 NC_013081.1 highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p Far1p and Pho4p cargo dissociation involves binding to RanGTP; KLTH0E03058p 276630 8291763 KLTH0E03058g Lachancea thermotolerans CBS 6340 KLTH0E03058p XP_002553618.1 272968 R 559295 CDS KLTH0E03080g 255714675 8291764 complement(277387..278463) 1 NC_013081.1 conserved hypothetical protein; KLTH0E03080p 278463 8291764 KLTH0E03080g Lachancea thermotolerans CBS 6340 KLTH0E03080p XP_002553619.1 277387 R 559295 CDS KLTH0E03102g 255714677 8291765 278921..280168 1 NC_013081.1 similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF; KLTH0E03102p 280168 8291765 KLTH0E03102g Lachancea thermotolerans CBS 6340 KLTH0E03102p XP_002553620.1 278921 D 559295 CDS KLTH0E03124g 255714679 8291766 complement(280411..283056) 1 NC_013081.1 weakly similar to uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF; KLTH0E03124p 283056 8291766 KLTH0E03124g Lachancea thermotolerans CBS 6340 KLTH0E03124p XP_002553621.1 280411 R 559295 CDS KLTH0E03146g 255714681 8291767 283871..285379 1 NC_013081.1 conserved hypothetical protein; KLTH0E03146p 285379 8291767 KLTH0E03146g Lachancea thermotolerans CBS 6340 KLTH0E03146p XP_002553622.1 283871 D 559295 CDS KLTH0E03168g 255714683 8291768 complement(285658..286104) 1 NC_013081.1 conserved hypothetical protein; KLTH0E03168p 286104 8291768 KLTH0E03168g Lachancea thermotolerans CBS 6340 KLTH0E03168p XP_002553623.1 285658 R 559295 CDS KLTH0E03212g 255714685 8291769 complement(290159..291568) 1 NC_013081.1 conserved hypothetical protein; KLTH0E03212p 291568 8291769 KLTH0E03212g Lachancea thermotolerans CBS 6340 KLTH0E03212p XP_002553624.1 290159 R 559295 CDS KLTH0E03234g 255714687 8291770 complement(293162..294727) 1 NC_013081.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease;ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression; KLTH0E03234p 294727 8291770 KLTH0E03234g Lachancea thermotolerans CBS 6340 KLTH0E03234p XP_002553625.1 293162 R 559295 CDS KLTH0E03256g 255714689 8291771 complement(294997..297021) 1 NC_013081.1 weakly similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C Hypothetical ORF; KLTH0E03256p 297021 8291771 KLTH0E03256g Lachancea thermotolerans CBS 6340 KLTH0E03256p XP_002553626.1 294997 R 559295 CDS KLTH0E03278g 255714691 8291772 complement(297218..298024) 1 NC_013081.1 conserved hypothetical protein; KLTH0E03278p 298024 8291772 KLTH0E03278g Lachancea thermotolerans CBS 6340 KLTH0E03278p XP_002553627.1 297218 R 559295 CDS KLTH0E03344g 255714693 8291775 complement(300629..301930) 1 NC_013081.1 conserved hypothetical protein; KLTH0E03344p 301930 8291775 KLTH0E03344g Lachancea thermotolerans CBS 6340 KLTH0E03344p XP_002553628.1 300629 R 559295 CDS KLTH0E03366g 255714695 8291776 302895..303683 1 NC_013081.1 conserved hypothetical protein; KLTH0E03366p 303683 8291776 KLTH0E03366g Lachancea thermotolerans CBS 6340 KLTH0E03366p XP_002553629.1 302895 D 559295 CDS KLTH0E03410g 255714697 8291778 complement(305592..306473) 1 NC_013081.1 highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit contains a sigma(70)-like motif which is thought to bind RNA; KLTH0E03410p 306473 8291778 KLTH0E03410g Lachancea thermotolerans CBS 6340 KLTH0E03410p XP_002553630.1 305592 R 559295 CDS KLTH0E03432g 255714699 8291779 308140..310341 1 NC_013081.1 conserved hypothetical protein; KLTH0E03432p 310341 8291779 KLTH0E03432g Lachancea thermotolerans CBS 6340 KLTH0E03432p XP_002553631.1 308140 D 559295 CDS KLTH0E03454g 255714701 8291780 complement(310411..310737) 1 NC_013081.1 similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W Hypothetical ORF; KLTH0E03454p 310737 8291780 KLTH0E03454g Lachancea thermotolerans CBS 6340 KLTH0E03454p XP_002553632.1 310411 R 559295 CDS KLTH0E03476g 255714703 8291781 complement(311391..315815) 1 NC_013081.1 some similarities with uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase component of the SWR1 complex required for the incorporation of Htz1p into chromatin; KLTH0E03476p 315815 8291781 KLTH0E03476g Lachancea thermotolerans CBS 6340 KLTH0E03476p XP_002553633.1 311391 R 559295 CDS KLTH0E03520g 255714705 8291783 complement(317318..318868) 1 NC_013081.1 similar to uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein component of the U1 snRNP protein mutants are defective in meiotic recombination and in formation of viable spores involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA; KLTH0E03520p 318868 8291783 KLTH0E03520g Lachancea thermotolerans CBS 6340 KLTH0E03520p XP_002553634.1 317318 R 559295 CDS KLTH0E03542g 255714707 8291784 complement(319728..320810) 1 NC_013081.1 similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Protein of unknown function essential for viability may be involved in rRNA processing; KLTH0E03542p 320810 8291784 KLTH0E03542g Lachancea thermotolerans CBS 6340 KLTH0E03542p XP_002553635.1 319728 R 559295 CDS KLTH0E03564g 255714709 8291785 320984..323116 1 NC_013081.1 similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Hypothetical ORF; KLTH0E03564p 323116 8291785 KLTH0E03564g Lachancea thermotolerans CBS 6340 KLTH0E03564p XP_002553636.1 320984 D 559295 CDS KLTH0E03586g 255714711 8291786 complement(323231..325336) 1 NC_013081.1 similar to uniprot|P13574 Saccharomyces cerevisiae YHR084W STE12 Transcription factor that is activated by a MAP kinase signaling cascade activates genes involved in mating or pseudohyphal/invasive growth pathways cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; KLTH0E03586p 325336 8291786 KLTH0E03586g Lachancea thermotolerans CBS 6340 KLTH0E03586p XP_002553637.1 323231 R 559295 CDS KLTH0E03608g 255714713 8291787 complement(325715..326689) 1 NC_013081.1 similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex aka TOB complex) of the mitochondrial outer membrane which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane; KLTH0E03608p 326689 8291787 KLTH0E03608g Lachancea thermotolerans CBS 6340 KLTH0E03608p XP_002553638.1 325715 R 559295 CDS KLTH0E03630g 255714715 8291788 complement(327367..329385) 1 NC_013081.1 similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W Hypothetical ORF; KLTH0E03630p 329385 8291788 KLTH0E03630g Lachancea thermotolerans CBS 6340 KLTH0E03630p XP_002553639.1 327367 R 559295 CDS KLTH0E03652g 255714717 8291789 330227..332671 1 NC_013081.1 similar to uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role overproduction causes allele-specific suppression of the prp20-10 mutation; KLTH0E03652p 332671 8291789 KLTH0E03652g Lachancea thermotolerans CBS 6340 KLTH0E03652p XP_002553640.1 330227 D 559295 CDS KLTH0E03674g 255714719 8291790 complement(333386..334588) 1 NC_013081.1 similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; KLTH0E03674p 334588 8291790 KLTH0E03674g Lachancea thermotolerans CBS 6340 KLTH0E03674p XP_002553641.1 333386 R 559295 CDS KLTH0E03696g 255714721 8291791 complement(335419..336852) 1 NC_013081.1 similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p; KLTH0E03696p 336852 8291791 KLTH0E03696g Lachancea thermotolerans CBS 6340 KLTH0E03696p XP_002553642.1 335419 R 559295 CDS KLTH0E03718g 255714723 8291792 complement(337034..337585) 1 NC_013081.1 similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs homolog of mammalian nuclear matrix protein C1D which is involved in regulation of DNA repair and recombination; KLTH0E03718p 337585 8291792 KLTH0E03718g Lachancea thermotolerans CBS 6340 KLTH0E03718p XP_002553643.1 337034 R 559295 CDS KLTH0E03740g 255714725 8291793 337770..338270 1 NC_013081.1 conserved hypothetical protein; KLTH0E03740p 338270 8291793 KLTH0E03740g Lachancea thermotolerans CBS 6340 KLTH0E03740p XP_002553644.1 337770 D 559295 CDS KLTH0E03762g 255714727 8291794 338481..339875 1 NC_013081.1 similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 peroxisomal membrane protein; KLTH0E03762p 339875 8291794 KLTH0E03762g Lachancea thermotolerans CBS 6340 KLTH0E03762p XP_002553645.1 338481 D 559295 CDS KLTH0E03784g 255714729 8291795 340081..340638 1 NC_013081.1 similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 evolutionarily conserved kinetochore protein that is part of multiple protein complexes; KLTH0E03784p 340638 8291795 KLTH0E03784g Lachancea thermotolerans CBS 6340 KLTH0E03784p XP_002553646.1 340081 D 559295 CDS KLTH0E03806g 255714731 8291796 341138..345013 1 NC_013081.1 weakly similar to uniprot|P38800 Saccharomyces cerevisiae YHR080C Hypothetical ORF; KLTH0E03806p 345013 8291796 KLTH0E03806g Lachancea thermotolerans CBS 6340 KLTH0E03806p XP_002553647.1 341138 D 559295 CDS KLTH0E03828g 255714733 8291797 345775..349131 1 NC_013081.1 similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing; KLTH0E03828p 349131 8291797 KLTH0E03828g Lachancea thermotolerans CBS 6340 KLTH0E03828p XP_002553648.1 345775 D 559295 CDS KLTH0E03850g 255714735 8291798 complement(349243..352308) 1 NC_013081.1 similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Yeast Condensin G; KLTH0E03850p 352308 8291798 KLTH0E03850g Lachancea thermotolerans CBS 6340 KLTH0E03850p XP_002553649.1 349243 R 559295 CDS KLTH0E03872g 255714737 8291799 353271..355511 1 NC_013081.1 similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0E03872p 355511 8291799 KLTH0E03872g Lachancea thermotolerans CBS 6340 KLTH0E03872p XP_002553650.1 353271 D 559295 CDS KLTH0E03894g 255714739 8291800 complement(355551..357152) 1 NC_013081.1 similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W Hypothetical ORF; KLTH0E03894p 357152 8291800 KLTH0E03894g Lachancea thermotolerans CBS 6340 KLTH0E03894p XP_002553651.1 355551 R 559295 CDS KLTH0E03916g 255714741 8291801 357296..358855 1 NC_013081.1 similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high- fidelity vesicle docking and fusion which are essential for targeting of vesicles to the endosome required for vacuole inheritance; KLTH0E03916p 358855 8291801 KLTH0E03916g Lachancea thermotolerans CBS 6340 KLTH0E03916p XP_002553652.1 357296 D 559295 CDS KLTH0E03938g 255714743 8291802 join(359015..359020,359091..362291) 1 NC_013081.1 similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense- mediated mRNA decay (NMD) pathway interacts with Nam7p and Upf3p; KLTH0E03938p 362291 8291802 KLTH0E03938g Lachancea thermotolerans CBS 6340 KLTH0E03938p XP_002553653.1 359015 D 559295 CDS KLTH0E03960g 255714745 8291803 complement(362321..363349) 1 NC_013081.1 similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Mitochondrially localized type 2C protein phosphatase expression induced by growth on ethanol and by sustained osmotic stress possible role in carbon source utilization in low oxygen environments; KLTH0E03960p 363349 8291803 KLTH0E03960g Lachancea thermotolerans CBS 6340 KLTH0E03960p XP_002553654.1 362321 R 559295 CDS KLTH0E03982g 255714747 8291804 363598..363876 1 NC_013081.1 similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0- ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric state of ATP synthase; KLTH0E03982p 363876 8291804 KLTH0E03982g Lachancea thermotolerans CBS 6340 KLTH0E03982p XP_002553655.1 363598 D 559295 CDS KLTH0E04004g 255714749 8291805 complement(364090..365163) 1 NC_013081.1 similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit; KLTH0E04004p 365163 8291805 KLTH0E04004g Lachancea thermotolerans CBS 6340 KLTH0E04004p XP_002553656.1 364090 R 559295 CDS KLTH0E04026g 255714751 8291806 366407..369019 1 NC_013081.1 weakly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase; KLTH0E04026p 369019 8291806 KLTH0E04026g Lachancea thermotolerans CBS 6340 KLTH0E04026p XP_002553657.1 366407 D 559295 CDS KLTH0E04048g 255714753 8291807 complement(369100..370464) 1 NC_013081.1 similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Mannosidase essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis involved in filamentous growth homologous to Dcw1p; KLTH0E04048p 370464 8291807 KLTH0E04048g Lachancea thermotolerans CBS 6340 KLTH0E04048p XP_002553658.1 369100 R 559295 CDS KLTH0E04070g 255714755 8291808 complement(370706..372865) 1 NC_013081.1 similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W BUD7 Protein involved in bud-site selection diploid mutants display an axial-like budding pattern; KLTH0E04070p 372865 8291808 KLTH0E04070g Lachancea thermotolerans CBS 6340 KLTH0E04070p XP_002553659.1 370706 R 559295 CDS KLTH0E04092g 255714757 8291809 complement(373159..373599) 1 NC_013081.1 similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9; KLTH0E04092p 373599 8291809 KLTH0E04092g Lachancea thermotolerans CBS 6340 KLTH0E04092p XP_002553660.1 373159 R 559295 CDS KLTH0E04114g 255714759 8291810 374102..374557 1 NC_013081.1 highly similar to uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; KLTH0E04114p 374557 8291810 KLTH0E04114g Lachancea thermotolerans CBS 6340 KLTH0E04114p XP_002553661.1 374102 D 559295 CDS KLTH0E04136g 255714761 8291811 374713..375945 1 NC_013081.1 similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p involved in nuclear transport; KLTH0E04136p 375945 8291811 KLTH0E04136g Lachancea thermotolerans CBS 6340 KLTH0E04136p XP_002553662.1 374713 D 559295 CDS KLTH0E04158g 255714763 8291812 complement(375986..377395) 1 NC_013081.1 weakly similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; KLTH0E04158p 377395 8291812 KLTH0E04158g Lachancea thermotolerans CBS 6340 KLTH0E04158p XP_002553663.1 375986 R 559295 CDS KLTH0E04180g 255714765 8291813 377813..378382 1 NC_013081.1 weakly similar to uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 mitochondrial inner membrane translocase; KLTH0E04180p 378382 8291813 KLTH0E04180g Lachancea thermotolerans CBS 6340 KLTH0E04180p XP_002553664.1 377813 D 559295 CDS KLTH0E04202g 255714767 8291814 complement(378494..379639) 1 NC_013081.1 similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'- end of a DNA strand; KLTH0E04202p 379639 8291814 KLTH0E04202g Lachancea thermotolerans CBS 6340 KLTH0E04202p XP_002553665.1 378494 R 559295 CDS KLTH0E04224g 255714769 8291815 complement(380176..384102) 1 NC_013081.1 similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W Hypothetical ORF; KLTH0E04224p 384102 8291815 KLTH0E04224g Lachancea thermotolerans CBS 6340 KLTH0E04224p XP_002553666.1 380176 R 559295 CDS KLTH0E04246g 255714771 8291816 complement(join(384279..384872,384938..384973)) 1 NC_013081.1 similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W and to uniprot|Q08747 Saccharomyces cerevisiae YOR295W UAF30; KLTH0E04246p 384973 8291816 KLTH0E04246g Lachancea thermotolerans CBS 6340 KLTH0E04246p XP_002553667.1 384279 R 559295 CDS KLTH0E04268g 255714773 8291817 complement(385182..385799) 1 NC_013081.1 highly similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice; KLTH0E04268p 385799 8291817 KLTH0E04268g Lachancea thermotolerans CBS 6340 KLTH0E04268p XP_002553668.1 385182 R 559295 CDS KLTH0E04290g 255714775 8291818 complement(386032..388005) 1 NC_013081.1 similar to uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating; KLTH0E04290p 388005 8291818 KLTH0E04290g Lachancea thermotolerans CBS 6340 KLTH0E04290p XP_002553669.1 386032 R 559295 CDS KLTH0E04312g 255714777 8291819 complement(388173..391268) 1 NC_013081.1 similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p; KLTH0E04312p 391268 8291819 KLTH0E04312g Lachancea thermotolerans CBS 6340 KLTH0E04312p XP_002553670.1 388173 R 559295 CDS KLTH0E04334g 255714779 8291820 complement(391495..393723) 1 NC_013081.1 similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p; KLTH0E04334p 393723 8291820 KLTH0E04334g Lachancea thermotolerans CBS 6340 KLTH0E04334p XP_002553671.1 391495 R 559295 CDS KLTH0E04356g 255714781 8291821 complement(join(394583..395791,395863..395877)) 1 NC_013081.1 similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting; KLTH0E04356p 395877 8291821 KLTH0E04356g Lachancea thermotolerans CBS 6340 KLTH0E04356p XP_002553672.1 394583 R 559295 CDS KLTH0E04378g 255714783 8291822 396019..397332 1 NC_013081.1 some similarities with uniprot|P40544 Saccharomyces cerevisiae YIL023C Hypothetical ORF; KLTH0E04378p 397332 8291822 KLTH0E04378g Lachancea thermotolerans CBS 6340 KLTH0E04378p XP_002553673.1 396019 D 559295 CDS KLTH0E04400g 255714785 8291823 397784..399256 1 NC_013081.1 weakly similar to uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5; KLTH0E04400p 399256 8291823 KLTH0E04400g Lachancea thermotolerans CBS 6340 KLTH0E04400p XP_002553674.1 397784 D 559295 CDS KLTH0E04422g 255714787 8291824 join(399577..399762,399861..400280) 1 NC_013081.1 similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Hypothetical ORF; KLTH0E04422p 400280 8291824 KLTH0E04422g Lachancea thermotolerans CBS 6340 KLTH0E04422p XP_002553675.1 399577 D 559295 CDS KLTH0E04444g 255714789 8291825 400548..403871 1 NC_013081.1 similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms essential for viability; KLTH0E04444p 403871 8291825 KLTH0E04444g Lachancea thermotolerans CBS 6340 KLTH0E04444p XP_002553676.1 400548 D 559295 CDS KLTH0E04466g 255714791 8291826 404040..404477 1 NC_013081.1 similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Protein of unknown function null mutant shows K1 killer toxin resistance; KLTH0E04466p 404477 8291826 KLTH0E04466g Lachancea thermotolerans CBS 6340 KLTH0E04466p XP_002553677.1 404040 D 559295 CDS KLTH0E04488g 255714793 8291827 complement(404527..404832) 1 NC_013081.1 some similarities with uniprot|P14724 Saccharomyces cerevisiae YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); KLTH0E04488p 404832 8291827 KLTH0E04488g Lachancea thermotolerans CBS 6340 KLTH0E04488p XP_002553678.1 404527 R 559295 CDS KLTH0E04510g 255714795 8291828 405275..409048 1 NC_013081.1 weakly similar to uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein; KLTH0E04510p 409048 8291828 KLTH0E04510g Lachancea thermotolerans CBS 6340 KLTH0E04510p XP_002553679.1 405275 D 559295 CDS KLTH0E04532g 255714797 8291829 complement(409294..412407) 1 NC_013081.1 weakly similar to uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects potential Cdc28p substrate; KLTH0E04532p 412407 8291829 KLTH0E04532g Lachancea thermotolerans CBS 6340 KLTH0E04532p XP_002553680.1 409294 R 559295 CDS KLTH0E04554g 255714799 8291830 412896..414335 1 NC_013081.1 similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 48.8 kDa protein involved in mitochondrial protein import; KLTH0E04554p 414335 8291830 KLTH0E04554g Lachancea thermotolerans CBS 6340 KLTH0E04554p XP_002553681.1 412896 D 559295 CDS KLTH0E04576g 255714801 8291831 complement(414398..414745) 1 NC_013081.1 conserved hypothetical protein; KLTH0E04576p 414745 8291831 KLTH0E04576g Lachancea thermotolerans CBS 6340 KLTH0E04576p XP_002553682.1 414398 R 559295 CDS KLTH0E04598g 255714803 8291832 415348..416334 1 NC_013081.1 similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W; KLTH0E04598p 416334 8291832 KLTH0E04598g Lachancea thermotolerans CBS 6340 KLTH0E04598p XP_002553683.1 415348 D 559295 CDS KLTH0E04620g 255714805 8291833 complement(416419..417219) 1 NC_013081.1 highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1- phosphoribosyl-4- imidazolecarboxiamide isomerase catalyzes the fourth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts; KLTH0E04620p 417219 8291833 KLTH0E04620g Lachancea thermotolerans CBS 6340 KLTH0E04620p XP_002553684.1 416419 R 559295 CDS KLTH0E04642g 255714807 8291834 417387..418391 1 NC_013081.1 similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly; KLTH0E04642p 418391 8291834 KLTH0E04642g Lachancea thermotolerans CBS 6340 KLTH0E04642p XP_002553685.1 417387 D 559295 CDS KLTH0E04664g 255714809 8291835 419041..420441 1 NC_013081.1 some similarities with uniprot|P07270 Saccharomyces cerevisiae YFR034C PHO4 Basic helix-loop- helix (bHLH) transcription factor binds cooperatively with Pho2p to the PHO5 promoter function is regulated by phosphorylation at multiple sites and by phosphate availability; KLTH0E04664p 420441 8291835 KLTH0E04664g Lachancea thermotolerans CBS 6340 KLTH0E04664p XP_002553686.1 419041 D 559295 CDS KLTH0E04686g 255714811 8291836 420873..421382 1 NC_013081.1 weakly similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa); KLTH0E04686p 421382 8291836 KLTH0E04686g Lachancea thermotolerans CBS 6340 KLTH0E04686p XP_002553687.1 420873 D 559295 CDS KLTH0E04708g 255714813 8291837 422806..422994 1 NC_013081.1 highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit; KLTH0E04708p 422994 8291837 KLTH0E04708g Lachancea thermotolerans CBS 6340 KLTH0E04708p XP_002553688.1 422806 D 559295 CDS KLTH0E04730g 255714815 8291838 423242..424117 1 NC_013081.1 weakly similar to uniprot|P43607 Saccharomyces cerevisiae YFR032C Hypothetical ORF; KLTH0E04730p 424117 8291838 KLTH0E04730g Lachancea thermotolerans CBS 6340 KLTH0E04730p XP_002553689.1 423242 D 559295 CDS KLTH0E04752g 255714817 8291839 join(425094..425097,425400..426160) 1 NC_013081.1 highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018w RPL5A and highly similar to uniprot|P05736 Saccharomyces cerevisiae YFR031ca RPL5B Protein component of the large (60S) ribosomal subunit; KLTH0E04752p 426160 8291839 KLTH0E04752g Lachancea thermotolerans CBS 6340 KLTH0E04752p XP_002553690.1 425094 D 559295 CDS KLTH0E04774g 255714819 8291840 426535..430047 1 NC_013081.1 similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Component of the condensin complex essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase Smc2p/Smc4p complex binds DNA possibly in the cleft formed by the coiled-coil of the folded dimer; KLTH0E04774p 430047 8291840 KLTH0E04774g Lachancea thermotolerans CBS 6340 KLTH0E04774p XP_002553691.1 426535 D 559295 CDS KLTH0E04796g 255714821 8291841 complement(430153..433263) 1 NC_013081.1 similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase which is responsible for the conversion of sulfite into sulfide; KLTH0E04796p 433263 8291841 KLTH0E04796g Lachancea thermotolerans CBS 6340 KLTH0E04796p XP_002553692.1 430153 R 559295 CDS KLTH0E04818g 255714823 8291842 complement(433487..436198) 1 NC_013081.1 similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Vacuole import and degradation; KLTH0E04818p 436198 8291842 KLTH0E04818g Lachancea thermotolerans CBS 6340 KLTH0E04818p XP_002553693.1 433487 R 559295 CDS KLTH0E04840g 255714825 8291843 436597..437133 1 NC_013081.1 some similarities with uniprot|P40548 Saccharomyces cerevisiae YIL016W SNL1 Integral membrane protein containing a Bag domain suppressor of nup116-C lethal; KLTH0E04840p 437133 8291843 KLTH0E04840g Lachancea thermotolerans CBS 6340 KLTH0E04840p XP_002553694.1 436597 D 559295 CDS KLTH0E04862g 255714827 8291844 437543..438250 1 NC_013081.1 similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase catalyzes the last step of the riboflavin biosynthesis pathway; KLTH0E04862p 438250 8291844 KLTH0E04862g Lachancea thermotolerans CBS 6340 KLTH0E04862p XP_002553695.1 437543 D 559295 CDS KLTH0E04884g 255714829 8291845 complement(438303..439622) 1 NC_013081.1 similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification contains multiple WD repeats interacts with Qsr1p in the two-hybrid system; KLTH0E04884p 439622 8291845 KLTH0E04884g Lachancea thermotolerans CBS 6340 KLTH0E04884p XP_002553696.1 438303 R 559295 CDS KLTH0E04906g 255714831 8291846 440170..441069 1 NC_013081.1 similar to uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein that interacts with the karyopherin Srp1p may have a role with Srp1p in ubiquitin-mediated protein degradation; KLTH0E04906p 441069 8291846 KLTH0E04906g Lachancea thermotolerans CBS 6340 KLTH0E04906p XP_002553697.1 440170 D 559295 CDS KLTH0E04928g 255714833 8291847 join(441235..441294,441360..441656) 1 NC_013081.1 similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Hypothetical ORF identified by homology; KLTH0E04928p 441656 8291847 KLTH0E04928g Lachancea thermotolerans CBS 6340 KLTH0E04928p XP_002553698.1 441235 D 559295 CDS KLTH0E04950g 255714835 8291848 complement(441717..443321) 1 NC_013081.1 some similarities with uniprot|P38335 Saccharomyces cerevisiae YBR255W Protein of unknown function required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0E04950p 443321 8291848 KLTH0E04950g Lachancea thermotolerans CBS 6340 KLTH0E04950p XP_002553699.1 441717 R 559295 CDS KLTH0E04972g 255714837 8291849 443419..443931 1 NC_013081.1 similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 Trapp subunit of 20 kDa probable membrane protein mutations in the human homolog cause spondyloepiphyseal dysplasia tarda (SEDL) a genetically heterogeneous disorder characterized by short stature and early-onset osteoarthritis; KLTH0E04972p 443931 8291849 KLTH0E04972g Lachancea thermotolerans CBS 6340 KLTH0E04972p XP_002553700.1 443419 D 559295 CDS KLTH0E04994g 255714839 8291850 complement(443995..445623) 1 NC_013081.1 some similarities with uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p- Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules important for chromosome segregation; KLTH0E04994p 445623 8291850 KLTH0E04994g Lachancea thermotolerans CBS 6340 KLTH0E04994p XP_002553701.1 443995 R 559295 CDS KLTH0E05016g 255714841 8291851 complement(445941..446309) 1 NC_013081.1 similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Protein involved in transcription as part of the Srb/Mediator complex; KLTH0E05016p 446309 8291851 KLTH0E05016g Lachancea thermotolerans CBS 6340 KLTH0E05016p XP_002553702.1 445941 R 559295 CDS KLTH0E05038g 255714843 8291852 complement(446503..446973) 1 NC_013081.1 highly similar to YBR252W, uniprot|P33317 Saccharomyces cerevisiae YBR252W (DUT1); KLTH0E05038p 446973 8291852 KLTH0E05038g Lachancea thermotolerans CBS 6340 KLTH0E05038p XP_002553703.1 446503 R 559295 CDS KLTH0E05082g 255714845 8291854 complement(447921..449132) 1 NC_013081.1 similar to YGR111W, uniprot|P53265 Saccharomyces cerevisiae YGR111W; KLTH0E05082p 449132 8291854 KLTH0E05082g Lachancea thermotolerans CBS 6340 KLTH0E05082p XP_002553704.1 447921 R 559295 CDS KLTH0E05104g 255714847 8291855 complement(449481..453038) 1 NC_013081.1 similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a- factor mating pheromone required for axial budding pattern of haploid cells; KLTH0E05104p 453038 8291855 KLTH0E05104g Lachancea thermotolerans CBS 6340 KLTH0E05104p XP_002553705.1 449481 R 559295 CDS KLTH0E05148g 255714849 8291857 complement(453418..453705) 1 NC_013081.1 conserved hypothetical protein; KLTH0E05148p 453705 8291857 KLTH0E05148g Lachancea thermotolerans CBS 6340 KLTH0E05148p XP_002553706.1 453418 R 559295 CDS KLTH0E05170g 255714851 8291858 455057..456283 1 NC_013081.1 similar to uniprot|P30283 Saccharomyces cerevisiae YPR120C CLB5 B-type cyclin with a role in DNA replication during S phase has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p and uniprot|P32943 Saccharomyces cerevisiae YGR109C CLB6; KLTH0E05170p 456283 8291858 KLTH0E05170g Lachancea thermotolerans CBS 6340 KLTH0E05170p XP_002553707.1 455057 D 559295 CDS KLTH0E05192g 255714853 8291859 complement(456907..458370) 1 NC_013081.1 similar to uniprot|P24869 Saccharomyces cerevisiae YPR119W CLB2 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24868 Saccharomyces cerevisiae YGR108W CLB1; KLTH0E05192p 458370 8291859 KLTH0E05192g Lachancea thermotolerans CBS 6340 KLTH0E05192p XP_002553708.1 456907 R 559295 CDS KLTH0E05236g 255714855 8291861 complement(459700..460953) 1 NC_013081.1 highly similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W Methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1- phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; KLTH0E05236p 460953 8291861 KLTH0E05236g Lachancea thermotolerans CBS 6340 KLTH0E05236p XP_002553709.1 459700 R 559295 CDS KLTH0E05280g 255714857 8291863 461626..462387 1 NC_013081.1 weakly similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C Hypothetical ORF; KLTH0E05280p 462387 8291863 KLTH0E05280g Lachancea thermotolerans CBS 6340 KLTH0E05280p XP_002553710.1 461626 D 559295 CDS KLTH0E05302g 255714859 8291864 complement(join(462508..462734,462808..462817)) 1 NC_013081.1 similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; KLTH0E05302p 462817 8291864 KLTH0E05302g Lachancea thermotolerans CBS 6340 KLTH0E05302p XP_002553711.1 462508 R 559295 CDS KLTH0E05324g 255714861 8291865 462964..463791 1 NC_013081.1 similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 subunit of RNA polymerase II holoenzyme/mediator complex; KLTH0E05324p 463791 8291865 KLTH0E05324g Lachancea thermotolerans CBS 6340 KLTH0E05324p XP_002553712.1 462964 D 559295 CDS KLTH0E05346g 255714863 8291866 complement(463898..465709) 1 NC_013081.1 similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis constituent of several different pre-ribosomal particles; KLTH0E05346p 465709 8291866 KLTH0E05346g Lachancea thermotolerans CBS 6340 KLTH0E05346p XP_002553713.1 463898 R 559295 CDS KLTH0E05368g 255714865 8291867 465977..466504 1 NC_013081.1 similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Hypothetical ORF; KLTH0E05368p 466504 8291867 KLTH0E05368g Lachancea thermotolerans CBS 6340 KLTH0E05368p XP_002553714.1 465977 D 559295 CDS KLTH0E05390g 255714867 8291868 complement(466567..467571) 1 NC_013081.1 similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology belongs to the rhomboid-GlpG superfamily of intramembrane peptidases; KLTH0E05390p 467571 8291868 KLTH0E05390g Lachancea thermotolerans CBS 6340 KLTH0E05390p XP_002553715.1 466567 R 559295 CDS KLTH0E05412g 255714869 8291869 complement(467786..470611) 1 NC_013081.1 similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p Ypt31p and Sec4p involved in recycling of internalized proteins and regulation of Golgi secretory function; KLTH0E05412p 470611 8291869 KLTH0E05412g Lachancea thermotolerans CBS 6340 KLTH0E05412p XP_002553716.1 467786 R 559295 CDS KLTH0E05434g 255714871 8291870 complement(470916..478109) 1 NC_013081.1 similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Hypothetical ORF; KLTH0E05434p 478109 8291870 KLTH0E05434g Lachancea thermotolerans CBS 6340 KLTH0E05434p XP_002553717.1 470916 R 559295 CDS KLTH0E05456g 255714873 8291871 complement(480127..482205) 1 NC_013081.1 similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats required for telomere length regulation and telomere position effect; KLTH0E05456p 482205 8291871 KLTH0E05456g Lachancea thermotolerans CBS 6340 KLTH0E05456p XP_002553718.1 480127 R 559295 CDS KLTH0E05478g 255714875 8291872 482401..487293 1 NC_013081.1 similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin inhibited by Pds1p; KLTH0E05478p 487293 8291872 KLTH0E05478g Lachancea thermotolerans CBS 6340 KLTH0E05478p XP_002553719.1 482401 D 559295 CDS KLTH0E05500g 255714877 8291873 complement(487303..488139) 1 NC_013081.1 weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W Hypothetical ORF; KLTH0E05500p 488139 8291873 KLTH0E05500g Lachancea thermotolerans CBS 6340 KLTH0E05500p XP_002553720.1 487303 R 559295 CDS KLTH0E05522g 255714879 8291874 488343..488969 1 NC_013081.1 conserved hypothetical protein; KLTH0E05522p 488969 8291874 KLTH0E05522g Lachancea thermotolerans CBS 6340 KLTH0E05522p XP_002553721.1 488343 D 559295 CDS KLTH0E05544g 255714881 8291875 complement(489071..492214) 1 NC_013081.1 similar to uniprot|P48361 Saccharomyces cerevisiae YGR097W ASK10 Component of the RNA polymerase II holoenzyme phosphorylated in response to oxidative stress has a role in destruction of Ssn8p which relieves repression of stress-response genes; KLTH0E05544p 492214 8291875 KLTH0E05544g Lachancea thermotolerans CBS 6340 KLTH0E05544p XP_002553722.1 489071 R 559295 CDS KLTH0E05566g 255714883 8291876 complement(493049..493975) 1 NC_013081.1 similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Hypothetical ORF; KLTH0E05566p 493975 8291876 KLTH0E05566g Lachancea thermotolerans CBS 6340 KLTH0E05566p XP_002553723.1 493049 R 559295 CDS KLTH0E05588g 255714885 8291877 complement(494815..495861) 1 NC_013081.1 highly similar to uniprot|P00330 Saccharomyces cerevisiae YOL086C ADH1 Alcohol dehydrogenase involved in the production of certain carboxylate esters; KLTH0E05588p 495861 8291877 KLTH0E05588g Lachancea thermotolerans CBS 6340 KLTH0E05588p XP_002553724.1 494815 R 559295 CDS KLTH0E05610g 255714887 8291878 complement(496524..497189) 1 NC_013081.1 similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase required for biosynthesis of phosphatidylinositol which is a precursor for polyphosphoinositides sphingolipids and glycolipid anchors for some of the plasma membrane proteins; KLTH0E05610p 497189 8291878 KLTH0E05610g Lachancea thermotolerans CBS 6340 KLTH0E05610p XP_002553725.1 496524 R 559295 CDS KLTH0E05632g 255714889 8291879 complement(497958..498728) 1 NC_013081.1 highly similar to uniprot|P29453 Saccharomyces cerevisiae RPL8B and to YHL033C uniprot|P17076 Saccharomyces cerevisiae RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit; KLTH0E05632p 498728 8291879 KLTH0E05632g Lachancea thermotolerans CBS 6340 KLTH0E05632p XP_002553726.1 497958 R 559295 CDS KLTH0E05654g 255714891 8291880 complement(499361..501421) 1 NC_013081.1 similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase converts glycerol to glycerol- 3-phosphate glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p derepression of expression on non- fermentable carbon sources is mediated by Opi1p and Rsf1p; KLTH0E05654p 501421 8291880 KLTH0E05654g Lachancea thermotolerans CBS 6340 KLTH0E05654p XP_002553727.1 499361 R 559295 CDS KLTH0E05676g 255714893 8291881 502686..504530 1 NC_013081.1 similar to uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane glycerol channel member of the major intrinsic protein (MIP) family of channel proteins involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite; KLTH0E05676p 504530 8291881 KLTH0E05676g Lachancea thermotolerans CBS 6340 KLTH0E05676p XP_002553728.1 502686 D 559295 CDS KLTH0E05698g 255714895 8291882 complement(504588..505232) 1 NC_013081.1 similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport homolog of the mammalian protein GOS-28/GS28; KLTH0E05698p 505232 8291882 KLTH0E05698g Lachancea thermotolerans CBS 6340 KLTH0E05698p XP_002553729.1 504588 R 559295 CDS KLTH0E05720g 255714897 8291883 complement(505291..505767) 1 NC_013081.1 weakly similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Enzyme that mediates formation of the Atg12p-Atg5p conjugate which is a critical step in autophagy; KLTH0E05720p 505767 8291883 KLTH0E05720g Lachancea thermotolerans CBS 6340 KLTH0E05720p XP_002553730.1 505291 R 559295 CDS KLTH0E05742g 255714899 8291884 complement(505942..506733) 1 NC_013081.1 highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; KLTH0E05742p 506733 8291884 KLTH0E05742g Lachancea thermotolerans CBS 6340 KLTH0E05742p XP_002553731.1 505942 R 559295 CDS KLTH0E05764g 255714901 8291885 complement(507436..516744) 1 NC_013081.1 similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 homologous to human COH1 component of peripheral vacuolar membrane protein complex; KLTH0E05764p 516744 8291885 KLTH0E05764g Lachancea thermotolerans CBS 6340 KLTH0E05764p XP_002553732.1 507436 R 559295 CDS KLTH0E05786g 255714903 8291886 517896..520349 1 NC_013081.1 weakly similar to uniprot|P39961 Saccharomyces cerevisiae YER184C Hypothetical ORF; KLTH0E05786p 520349 8291886 KLTH0E05786g Lachancea thermotolerans CBS 6340 KLTH0E05786p XP_002553733.1 517896 D 559295 CDS KLTH0E05808g 255714905 8291887 520621..521553 1 NC_013081.1 similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF; KLTH0E05808p 521553 8291887 KLTH0E05808g Lachancea thermotolerans CBS 6340 KLTH0E05808p XP_002553734.1 520621 D 559295 CDS KLTH0E05830g 255714907 8291888 523206..528761 1 NC_013081.1 similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Major component of the proteasome tethers the proteasome core particle to the regulatory particle and enhances the stability of the proteasome; KLTH0E05830p 528761 8291888 KLTH0E05830g Lachancea thermotolerans CBS 6340 KLTH0E05830p XP_002553735.1 523206 D 559295 CDS KLTH0E05852g 255714909 8291889 complement(528861..530090) 1 NC_013081.1 highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039c UBI4 ubiquitin; KLTH0E05852p 530090 8291889 KLTH0E05852g Lachancea thermotolerans CBS 6340 KLTH0E05852p XP_002553736.1 528861 R 559295 CDS KLTH0E05874g 255714911 8291890 complement(530814..531581) 1 NC_013081.1 similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function contains an N- terminal epsin-like domain; KLTH0E05874p 531581 8291890 KLTH0E05874g Lachancea thermotolerans CBS 6340 KLTH0E05874p XP_002553737.1 530814 R 559295 CDS KLTH0E05896g 255714913 8291891 complement(join(531754..533294,533352..533364)) 1 NC_013081.1 similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome contains a U-box a motif found in a class of ubiquitin ligases; KLTH0E05896p 533364 8291891 KLTH0E05896g Lachancea thermotolerans CBS 6340 KLTH0E05896p XP_002553738.1 531754 R 559295 CDS KLTH0E05918g 255714915 8291892 complement(533655..535355) 1 NC_013081.1 similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive- strand RNA viruses in their natural hosts; KLTH0E05918p 535355 8291892 KLTH0E05918g Lachancea thermotolerans CBS 6340 KLTH0E05918p XP_002553739.1 533655 R 559295 CDS KLTH0E05940g 255714917 8291893 536972..538642 1 NC_013081.1 some similarities with uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 cell wall integrity and stress response component 4 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC3; KLTH0E05940p 538642 8291893 KLTH0E05940g Lachancea thermotolerans CBS 6340 KLTH0E05940p XP_002553740.1 536972 D 559295 CDS KLTH0E05962g 255714919 8291894 539474..540739 1 NC_013081.1 weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W; KLTH0E05962p 540739 8291894 KLTH0E05962g Lachancea thermotolerans CBS 6340 KLTH0E05962p XP_002553741.1 539474 D 559295 CDS KLTH0E05984g 255714921 8291895 join(540906..540915,541001..542904) 1 NC_013081.1 similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Protein of unknown function required for cell growth and possibly involved in rRNA processing mRNA is cell cycle regulated; KLTH0E05984p 542904 8291895 KLTH0E05984g Lachancea thermotolerans CBS 6340 KLTH0E05984p XP_002553742.1 540906 D 559295 CDS KLTH0E06006g 255714923 8291896 complement(542954..545413) 1 NC_013081.1 highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family required for export of pre-ribosomal large subunits from the nucleus distributed between the nucleolus nucleoplasm and nuclear periphery depending on growth conditions; KLTH0E06006p 545413 8291896 KLTH0E06006g Lachancea thermotolerans CBS 6340 KLTH0E06006p XP_002553743.1 542954 R 559295 CDS KLTH0E06028g 255714925 8291897 545638..546252 1 NC_013081.1 weakly similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W; KLTH0E06028p 546252 8291897 KLTH0E06028g Lachancea thermotolerans CBS 6340 KLTH0E06028p XP_002553744.1 545638 D 559295 CDS KLTH0E06050g 255714927 8291898 complement(546306..548399) 1 NC_013081.1 weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Hypothetical ORF; KLTH0E06050p 548399 8291898 KLTH0E06050g Lachancea thermotolerans CBS 6340 KLTH0E06050p XP_002553745.1 546306 R 559295 CDS KLTH0E06072g 255714929 8291899 549274..550182 1 NC_013081.1 weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex; KLTH0E06072p 550182 8291899 KLTH0E06072g Lachancea thermotolerans CBS 6340 KLTH0E06072p XP_002553746.1 549274 D 559295 CDS KLTH0E06094g 255714931 8291900 complement(550258..553308) 1 NC_013081.1 similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C; KLTH0E06094p 553308 8291900 KLTH0E06094g Lachancea thermotolerans CBS 6340 KLTH0E06094p XP_002553747.1 550258 R 559295 CDS KLTH0E06116g 255714933 8291901 complement(553784..556297) 1 NC_013081.1 some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; KLTH0E06116p 556297 8291901 KLTH0E06116g Lachancea thermotolerans CBS 6340 KLTH0E06116p XP_002553748.1 553784 R 559295 CDS KLTH0E06138g 255714935 8291902 558501..560345 1 NC_013081.1 similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification; KLTH0E06138p 560345 8291902 KLTH0E06138g Lachancea thermotolerans CBS 6340 KLTH0E06138p XP_002553749.1 558501 D 559295 CDS KLTH0E06160g 255714937 8291903 560782..562956 1 NC_013081.1 similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W Hypothetical ORF; KLTH0E06160p 562956 8291903 KLTH0E06160g Lachancea thermotolerans CBS 6340 KLTH0E06160p XP_002553750.1 560782 D 559295 CDS KLTH0E06182g 255714939 8291904 563423..564226 1 NC_013081.1 similar to uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency depletion reduces growth on nonfermentable carbon sources; KLTH0E06182p 564226 8291904 KLTH0E06182g Lachancea thermotolerans CBS 6340 KLTH0E06182p XP_002553751.1 563423 D 559295 CDS KLTH0E06204g 255714941 8291905 564895..567618 1 NC_013081.1 highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured aggregated proteins responsive to stresses including: heat ethanol and sodium arsenite involved in [PSI ] propagation; KLTH0E06204p 567618 8291905 KLTH0E06204g Lachancea thermotolerans CBS 6340 KLTH0E06204p XP_002553752.1 564895 D 559295 CDS KLTH0E06226g 255714943 8291906 568785..571112 1 NC_013081.1 weakly similar to uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes; KLTH0E06226p 571112 8291906 KLTH0E06226g Lachancea thermotolerans CBS 6340 KLTH0E06226p XP_002553753.1 568785 D 559295 CDS KLTH0E06248g 255714945 8291907 complement(571398..574007) 1 NC_013081.1 some similarities with uniprot|P38742 Saccharomyces cerevisiae YHL023C RMD11 Protein required for sporulation; KLTH0E06248p 574007 8291907 KLTH0E06248g Lachancea thermotolerans CBS 6340 KLTH0E06248p XP_002553754.1 571398 R 559295 CDS KLTH0E06292g 255714947 8291909 complement(575313..575921) 1 NC_013081.1 similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport; KLTH0E06292p 575921 8291909 KLTH0E06292g Lachancea thermotolerans CBS 6340 KLTH0E06292p XP_002553755.1 575313 R 559295 CDS KLTH0E06314g 255714949 8291910 complement(join(577084..577842,578360..578536)) 1 NC_013081.1 highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Catalytic subunit of type 1 serine/threonine protein phosphatase involved in many processes including glycogen metabolism sporulation and mitosis interacts with multiple regulatory subunits predominantly isolated with Sds22p; KLTH0E06314p 578536 8291910 KLTH0E06314g Lachancea thermotolerans CBS 6340 KLTH0E06314p XP_002553756.1 577084 R 559295 CDS KLTH0E06358g 255714951 8292401 579575..580306 1 NC_013081.1 some similarities with uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases computational analysis of large- scale protein- protein interaction data suggests a possible role in vesicle-mediated transport; KLTH0E06358p 580306 8292401 KLTH0E06358g Lachancea thermotolerans CBS 6340 KLTH0E06358p XP_002553757.1 579575 D 559295 CDS KLTH0E06380g 255714953 8291912 580587..585320 1 NC_013081.1 similar to uniprot|P53094 Saccharomyces cerevisiae YGL197W MDS3 Protein with an N-terminal kelch- like domain putative negative regulator of early meiotic gene expression required with Pmd1p for growth under alkaline conditions; KLTH0E06380p 585320 8291912 KLTH0E06380g Lachancea thermotolerans CBS 6340 KLTH0E06380p XP_002553758.1 580587 D 559295 CDS KLTH0E06424g 255714955 8292400 586109..594130 1 NC_013081.1 similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA; KLTH0E06424p 594130 8292400 KLTH0E06424g Lachancea thermotolerans CBS 6340 KLTH0E06424p XP_002553759.1 586109 D 559295 CDS KLTH0E06446g 255714957 8291914 complement(594807..596156) 1 NC_013081.1 highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails subunit of the Set3 complex a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; KLTH0E06446p 596156 8291914 KLTH0E06446g Lachancea thermotolerans CBS 6340 KLTH0E06446p XP_002553760.1 594807 R 559295 CDS KLTH0E06468g 255714959 8291915 596870..598438 1 NC_013081.1 similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation expression is induced in starved MATa/MAT alpha diploid cells; KLTH0E06468p 598438 8291915 KLTH0E06468g Lachancea thermotolerans CBS 6340 KLTH0E06468p XP_002553761.1 596870 D 559295 CDS KLTH0E06512g 255714961 8291917 599391..599774 1 NC_013081.1 similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; KLTH0E06512p 599774 8291917 KLTH0E06512g Lachancea thermotolerans CBS 6340 KLTH0E06512p XP_002553762.1 599391 D 559295 CDS KLTH0E06534g 255714963 8291918 complement(600189..601571) 1 NC_013081.1 similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A has multiple roles in mitosis and protein biosynthesis found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells); KLTH0E06534p 601571 8291918 KLTH0E06534g Lachancea thermotolerans CBS 6340 KLTH0E06534p XP_002553763.1 600189 R 559295 CDS KLTH0E06556g 255714965 8291919 complement(602002..602361) 1 NC_013081.1 highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C; KLTH0E06556p 602361 8291919 KLTH0E06556g Lachancea thermotolerans CBS 6340 KLTH0E06556p XP_002553764.1 602002 R 559295 CDS KLTH0E06578g 255714967 8291920 complement(603270..603737) 1 NC_013081.1 highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain N-terminal 25 residues of precursor are cleaved during mitochondrial import; KLTH0E06578p 603737 8291920 KLTH0E06578g Lachancea thermotolerans CBS 6340 KLTH0E06578p XP_002553765.1 603270 R 559295 CDS KLTH0E06600g 255714969 8291921 complement(604346..605974) 1 NC_013081.1 similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Pyridoxine transporter; KLTH0E06600p 605974 8291921 KLTH0E06600g Lachancea thermotolerans CBS 6340 KLTH0E06600p XP_002553766.1 604346 R 559295 CDS KLTH0E06622g 255714971 8291922 complement(606340..607473) 1 NC_013081.1 similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative hydroxyacid dehydrogenase; KLTH0E06622p 607473 8291922 KLTH0E06622g Lachancea thermotolerans CBS 6340 KLTH0E06622p XP_002553767.1 606340 R 559295 CDS KLTH0E06644g 255714973 8291923 complement(608116..609498) 1 NC_013081.1 highly similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine; KLTH0E06644p 609498 8291923 KLTH0E06644g Lachancea thermotolerans CBS 6340 KLTH0E06644p XP_002553768.1 608116 R 559295 CDS KLTH0E06666g 255714975 8291924 611348..614188 1 NC_013081.1 conserved hypothetical protein; KLTH0E06666p 614188 8291924 KLTH0E06666g Lachancea thermotolerans CBS 6340 KLTH0E06666p XP_002553769.1 611348 D 559295 CDS KLTH0E06688g 255714977 8291925 614548..615741 1 NC_013081.1 weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF; KLTH0E06688p 615741 8291925 KLTH0E06688g Lachancea thermotolerans CBS 6340 KLTH0E06688p XP_002553770.1 614548 D 559295 CDS KLTH0E06710g 255714979 8291926 complement(join(615944..616618,617037..617051)) 1 NC_013081.1 similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division; KLTH0E06710p 617051 8291926 KLTH0E06710g Lachancea thermotolerans CBS 6340 KLTH0E06710p XP_002553771.1 615944 R 559295 CDS KLTH0E06732g 255714981 8291927 617502..618557 1 NC_013081.1 some similarities with uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc- finger in the N- terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport; KLTH0E06732p 618557 8291927 KLTH0E06732g Lachancea thermotolerans CBS 6340 KLTH0E06732p XP_002553772.1 617502 D 559295 CDS KLTH0E06754g 255714983 8291928 619163..621784 1 NC_013081.1 similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; KLTH0E06754p 621784 8291928 KLTH0E06754g Lachancea thermotolerans CBS 6340 KLTH0E06754p XP_002553773.1 619163 D 559295 CDS KLTH0E06776g 255714985 8291929 complement(622147..625575) 1 NC_013081.1 weakly similar to uniprot|P38990 Saccharomyces cerevisiae YER129W PAK1 Upstream kinase for the SNF1 complex partially redundant function with Elm1p and Tos3p members of this family of kinases have functional orthology with LKB1 a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; KLTH0E06776p 625575 8291929 KLTH0E06776g Lachancea thermotolerans CBS 6340 KLTH0E06776p XP_002553774.1 622147 R 559295 CDS KLTH0E06798g 255714987 8291930 complement(626004..626624) 1 NC_013081.1 similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Hypothetical ORF; KLTH0E06798p 626624 8291930 KLTH0E06798g Lachancea thermotolerans CBS 6340 KLTH0E06798p XP_002553775.1 626004 R 559295 CDS KLTH0E06820g 255714989 8291931 complement(626764..627882) 1 NC_013081.1 similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA depletion leads to inhibited pre- rRNA processing and reduced polysome levels localizes primarily to the nucleolus; KLTH0E06820p 627882 8291931 KLTH0E06820g Lachancea thermotolerans CBS 6340 KLTH0E06820p XP_002553776.1 626764 R 559295 CDS KLTH0E06842g 255714991 8291932 628153..628938 1 NC_013081.1 highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; KLTH0E06842p 628938 8291932 KLTH0E06842g Lachancea thermotolerans CBS 6340 KLTH0E06842p XP_002553777.1 628153 D 559295 CDS KLTH0E06864g 255714993 8291933 630263..632461 1 NC_013081.1 weakly similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components has roles in longevity in maintenance of cell wall integrity and in sensitivity to and recovery from pheromone arrest; KLTH0E06864p 632461 8291933 KLTH0E06864g Lachancea thermotolerans CBS 6340 KLTH0E06864p XP_002553778.1 630263 D 559295 CDS KLTH0E06886g 255714995 8291934 complement(632946..634457) 1 NC_013081.1 some similarities with uniprot|P46945 Saccharomyces cerevisiae YGL176C; KLTH0E06886p 634457 8291934 KLTH0E06886g Lachancea thermotolerans CBS 6340 KLTH0E06886p XP_002553779.1 632946 R 559295 CDS KLTH0E06908g 255714997 8291935 complement(634745..637120) 1 NC_013081.1 highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting contains a hect (homologous to E6-AP carboxyl terminus) domain; KLTH0E06908p 637120 8291935 KLTH0E06908g Lachancea thermotolerans CBS 6340 KLTH0E06908p XP_002553780.1 634745 R 559295 CDS KLTH0E06930g 255714999 8291936 637945..639609 1 NC_013081.1 similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein may participate in pathways regulating cell wall metabolism deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall; KLTH0E06930p 639609 8291936 KLTH0E06930g Lachancea thermotolerans CBS 6340 KLTH0E06930p XP_002553781.1 637945 D 559295 CDS KLTH0E06952g 255715001 8291937 complement(639783..641045) 1 NC_013081.1 some similarities with uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 plasma membrane- bound casein kinase I homolog; KLTH0E06952p 641045 8291937 KLTH0E06952g Lachancea thermotolerans CBS 6340 KLTH0E06952p XP_002553782.1 639783 R 559295 CDS KLTH0E06974g 255715003 8291938 642495..643370 1 NC_013081.1 some similarities with uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor nonessential component of the NuA4 acetyltransferase complex homologous to Drosophila dosage compensation protein MSL3; KLTH0E06974p 643370 8291938 KLTH0E06974g Lachancea thermotolerans CBS 6340 KLTH0E06974p XP_002553783.1 642495 D 559295 CDS KLTH0E06996g 255715005 8291939 644098..646746 1 NC_013081.1 similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial transporter acts both as a glutamate uniporter and as an aspartate- glutamate exchanger involved in nitrogen metabolism ornithine synthesis and the malate-aspartate NADH shuttle; KLTH0E06996p 646746 8291939 KLTH0E06996g Lachancea thermotolerans CBS 6340 KLTH0E06996p XP_002553784.1 644098 D 559295 CDS KLTH0E07018g 255715007 8291940 complement(646863..647951) 1 NC_013081.1 weakly similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Protein with a role in accurate meiotic and mitotic double-strand break repair phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents; KLTH0E07018p 647951 8291940 KLTH0E07018g Lachancea thermotolerans CBS 6340 KLTH0E07018p XP_002553785.1 646863 R 559295 CDS KLTH0E07040g 255715009 8291941 648078..648899 1 NC_013081.1 weakly similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern; KLTH0E07040p 648899 8291941 KLTH0E07040g Lachancea thermotolerans CBS 6340 KLTH0E07040p XP_002553786.1 648078 D 559295 CDS KLTH0E07062g 255715011 8291942 complement(648999..653489) 1 NC_013081.1 similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 5'-3' exonuclease involved in mRNA decay evolutionarily conserved component of cytoplasmic processing (P) bodies plays a role in microtubule-mediated processes filamentous growth and ribosomal RNA maturation; KLTH0E07062p 653489 8291942 KLTH0E07062g Lachancea thermotolerans CBS 6340 KLTH0E07062p XP_002553787.1 648999 R 559295 CDS KLTH0E07084g 255715013 8291943 653966..655573 1 NC_013081.1 weakly similar to uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p- Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) required for nuclear export of ribosomes; KLTH0E07084p 655573 8291943 KLTH0E07084g Lachancea thermotolerans CBS 6340 KLTH0E07084p XP_002553788.1 653966 D 559295 CDS KLTH0E07106g 255715015 8291944 656129..657211 1 NC_013081.1 conserved hypothetical protein; KLTH0E07106p 657211 8291944 KLTH0E07106g Lachancea thermotolerans CBS 6340 KLTH0E07106p XP_002553789.1 656129 D 559295 CDS KLTH0E07128g 255715017 8291945 complement(657986..660064) 1 NC_013081.1 similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases which are serine/threonine kinases also capable of phosphorylating tyrosine residues; KLTH0E07128p 660064 8291945 KLTH0E07128g Lachancea thermotolerans CBS 6340 KLTH0E07128p XP_002553790.1 657986 R 559295 CDS KLTH0E07150g 255715019 8291946 complement(661556..662872) 1 NC_013081.1 conserved hypothetical protein; KLTH0E07150p 662872 8291946 KLTH0E07150g Lachancea thermotolerans CBS 6340 KLTH0E07150p XP_002553791.1 661556 R 559295 CDS KLTH0E07172g 255715021 8291947 664317..665540 1 NC_013081.1 similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Hypothetical ORF; KLTH0E07172p 665540 8291947 KLTH0E07172g Lachancea thermotolerans CBS 6340 KLTH0E07172p XP_002553792.1 664317 D 559295 CDS KLTH0E07194g 255715023 8291948 complement(665709..668324) 1 NC_013081.1 similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C Hypothetical ORF; KLTH0E07194p 668324 8291948 KLTH0E07194g Lachancea thermotolerans CBS 6340 KLTH0E07194p XP_002553793.1 665709 R 559295 CDS KLTH0E07216g 255715025 8291949 668587..668985 1 NC_013081.1 similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents expression is growth-regulated; KLTH0E07216p 668985 8291949 KLTH0E07216g Lachancea thermotolerans CBS 6340 KLTH0E07216p XP_002553794.1 668587 D 559295 CDS KLTH0E07260g 255715027 8291951 669667..670659 1 NC_013081.1 conserved hypothetical protein; KLTH0E07260p 670659 8291951 KLTH0E07260g Lachancea thermotolerans CBS 6340 KLTH0E07260p XP_002553795.1 669667 D 559295 CDS KLTH0E07282g 255715029 8291952 complement(670823..672571) 1 NC_013081.1 similar to uniprot|P53189 Saccharomyces cerevisiae YGL028C SCW11 Cell wall protein with similarity to glucanases; KLTH0E07282p 672571 8291952 KLTH0E07282g Lachancea thermotolerans CBS 6340 KLTH0E07282p XP_002553796.1 670823 R 559295 CDS KLTH0E07304g 255715031 8291953 complement(673288..675702) 1 NC_013081.1 similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I involved in assembly of cell wall beta 1 6 glucan and asparagine- linked protein glycosylation ER type II integral membrane N-glycoprotein disruption leads to a K1 killer toxin- resistant phenotype; KLTH0E07304p 675702 8291953 KLTH0E07304g Lachancea thermotolerans CBS 6340 KLTH0E07304p XP_002553797.1 673288 R 559295 CDS KLTH0E07326g 255715033 8291954 complement(676064..678766) 1 NC_013081.1 weakly similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn7p and TATA- binding protein; KLTH0E07326p 678766 8291954 KLTH0E07326g Lachancea thermotolerans CBS 6340 KLTH0E07326p XP_002553798.1 676064 R 559295 CDS KLTH0E07348g 255715035 8291955 complement(679054..681183) 1 NC_013081.1 highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 tryptophan synthetase; KLTH0E07348p 681183 8291955 KLTH0E07348g Lachancea thermotolerans CBS 6340 KLTH0E07348p XP_002553799.1 679054 R 559295 CDS KLTH0E07370g 255715037 8291956 complement(681382..682440) 1 NC_013081.1 weakly similar to uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1; KLTH0E07370p 682440 8291956 KLTH0E07370g Lachancea thermotolerans CBS 6340 KLTH0E07370p XP_002553800.1 681382 R 559295 CDS KLTH0E07392g 255715039 8291957 complement(682562..683455) 1 NC_013081.1 conserved hypothetical protein; KLTH0E07392p 683455 8291957 KLTH0E07392g Lachancea thermotolerans CBS 6340 KLTH0E07392p XP_002553801.1 682562 R 559295 CDS KLTH0E07414g 255715041 8291958 683534..684667 1 NC_013081.1 similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase catalyzes the formylation of initiator Met-tRNA in mitochondria potential Cdc28p substrate; KLTH0E07414p 684667 8291958 KLTH0E07414g Lachancea thermotolerans CBS 6340 KLTH0E07414p XP_002553802.1 683534 D 559295 CDS KLTH0E07458g 255715043 8291960 685283..687403 1 NC_013081.1 similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline- transport mutants; KLTH0E07458p 687403 8291960 KLTH0E07458g Lachancea thermotolerans CBS 6340 KLTH0E07458p XP_002553803.1 685283 D 559295 CDS KLTH0E07480g 255715045 8291961 complement(687623..689224) 1 NC_013081.1 weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C; KLTH0E07480p 689224 8291961 KLTH0E07480g Lachancea thermotolerans CBS 6340 KLTH0E07480p XP_002553804.1 687623 R 559295 CDS KLTH0E07502g 255715047 8291962 689680..691872 1 NC_013081.1 highly similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; KLTH0E07502p 691872 8291962 KLTH0E07502g Lachancea thermotolerans CBS 6340 KLTH0E07502p XP_002553805.1 689680 D 559295 CDS KLTH0E07524g 255715049 8291963 complement(691969..692691) 1 NC_013081.1 weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C Hypothetical ORF; KLTH0E07524p 692691 8291963 KLTH0E07524g Lachancea thermotolerans CBS 6340 KLTH0E07524p XP_002553806.1 691969 R 559295 CDS KLTH0E07546g 255715051 8291964 692912..694801 1 NC_013081.1 some similarities with uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin; KLTH0E07546p 694801 8291964 KLTH0E07546g Lachancea thermotolerans CBS 6340 KLTH0E07546p XP_002553807.1 692912 D 559295 CDS KLTH0E07568g 255715053 8291965 complement(694903..695490) 1 NC_013081.1 weakly similar to uniprot|P53192 Saccharomyces cerevisiae YGL020C MDM39 Protein involved in determination of mitochondrial structure; KLTH0E07568p 695490 8291965 KLTH0E07568g Lachancea thermotolerans CBS 6340 KLTH0E07568p XP_002553808.1 694903 R 559295 CDS KLTH0E07590g 255715055 8291966 695652..696404 1 NC_013081.1 similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2; KLTH0E07590p 696404 8291966 KLTH0E07590g Lachancea thermotolerans CBS 6340 KLTH0E07590p XP_002553809.1 695652 D 559295 CDS KLTH0E07612g 255715057 8291967 complement(696467..697027) 1 NC_013081.1 similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Molecular chaperone involved with partner Ssq1p in assembly of Fe/S clusters and in mitochondrial iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix; KLTH0E07612p 697027 8291967 KLTH0E07612g Lachancea thermotolerans CBS 6340 KLTH0E07612p XP_002553810.1 696467 R 559295 CDS KLTH0E07634g 255715059 8291968 697160..698794 1 NC_013081.1 similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; KLTH0E07634p 698794 8291968 KLTH0E07634g Lachancea thermotolerans CBS 6340 KLTH0E07634p XP_002553811.1 697160 D 559295 CDS KLTH0E07656g 255715061 8291969 699240..702146 1 NC_013081.1 similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance; KLTH0E07656p 702146 8291969 KLTH0E07656g Lachancea thermotolerans CBS 6340 KLTH0E07656p XP_002553812.1 699240 D 559295 CDS KLTH0E07678g 255715063 8291970 702610..704088 1 NC_013081.1 similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis; KLTH0E07678p 704088 8291970 KLTH0E07678g Lachancea thermotolerans CBS 6340 KLTH0E07678p XP_002553813.1 702610 D 559295 CDS KLTH0E07700g 255715065 8291971 705358..707778 1 NC_013081.1 similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes contributes to nucleosome formation heterochromatic gene silencing and formation of functional kinetochores; KLTH0E07700p 707778 8291971 KLTH0E07700g Lachancea thermotolerans CBS 6340 KLTH0E07700p XP_002553814.1 705358 D 559295 CDS KLTH0E07722g 255715067 8291972 708205..710556 1 NC_013081.1 highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase catalyzes the second step in the leucine biosynthesis pathway; KLTH0E07722p 710556 8291972 KLTH0E07722g Lachancea thermotolerans CBS 6340 KLTH0E07722p XP_002553815.1 708205 D 559295 CDS KLTH0E07744g 255715069 8291973 complement(710793..714542) 1 NC_013081.1 similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton contains 3 SH3 domains interacts with proteins regulating actin dynamics and with proteins required for endocytosis; KLTH0E07744p 714542 8291973 KLTH0E07744g Lachancea thermotolerans CBS 6340 KLTH0E07744p XP_002553816.1 710793 R 559295 CDS KLTH0E07766g 255715071 8291974 complement(714842..715351) 1 NC_013081.1 similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W Hypothetical ORF; KLTH0E07766p 715351 8291974 KLTH0E07766g Lachancea thermotolerans CBS 6340 KLTH0E07766p XP_002553817.1 714842 R 559295 CDS KLTH0E07788g 255715073 8291975 715745..716485 1 NC_013081.1 highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7); KLTH0E07788p 716485 8291975 KLTH0E07788g Lachancea thermotolerans CBS 6340 KLTH0E07788p XP_002553818.1 715745 D 559295 CDS KLTH0E07810g 255715075 8291976 complement(716624..717226) 1 NC_013081.1 weakly similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Protein of unknown function null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface; KLTH0E07810p 717226 8291976 KLTH0E07810g Lachancea thermotolerans CBS 6340 KLTH0E07810p XP_002553819.1 716624 R 559295 CDS KLTH0E07832g 255715077 8291977 complement(717500..718894) 1 NC_013081.1 similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase catalyzes the final step in ergosterol biosynthesis mutants are viable but lack ergosterol; KLTH0E07832p 718894 8291977 KLTH0E07832g Lachancea thermotolerans CBS 6340 KLTH0E07832p XP_002553820.1 717500 R 559295 CDS KLTH0E07854g 255715079 8291978 719642..722458 1 NC_013081.1 weakly similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; KLTH0E07854p 722458 8291978 KLTH0E07854g Lachancea thermotolerans CBS 6340 KLTH0E07854p XP_002553821.1 719642 D 559295 CDS KLTH0E07876g 255715081 8291979 complement(722528..724660) 1 NC_013081.1 similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 member of the PUF protein family YGL014W; KLTH0E07876p 724660 8291979 KLTH0E07876g Lachancea thermotolerans CBS 6340 KLTH0E07876p XP_002553822.1 722528 R 559295 CDS KLTH0E07898g 255715083 8291980 725950..727152 1 NC_013081.1 highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism; KLTH0E07898p 727152 8291980 KLTH0E07898g Lachancea thermotolerans CBS 6340 KLTH0E07898p XP_002553823.1 725950 D 559295 CDS KLTH0E07920g 255715085 8291981 728285..729487 1 NC_013081.1 highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism; KLTH0E07920p 729487 8291981 KLTH0E07920g Lachancea thermotolerans CBS 6340 KLTH0E07920p XP_002553824.1 728285 D 559295 CDS KLTH0E07942g 255715087 8291982 complement(730431..733136) 1 NC_013081.1 highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H -ATPase pumps protons out of the cell major regulator of cytoplasmic pH part of the P2 subgroup of cation-transporting ATPases; KLTH0E07942p 733136 8291982 KLTH0E07942g Lachancea thermotolerans CBS 6340 KLTH0E07942p XP_002553825.1 730431 R 559295 CDS KLTH0E07964g 255715089 8291983 735214..736338 1 NC_013081.1 similar to uniprot|P25377 Saccharomyces cerevisiae YCR105W ADH7 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis; KLTH0E07964p 736338 8291983 KLTH0E07964g Lachancea thermotolerans CBS 6340 KLTH0E07964p XP_002553826.1 735214 D 559295 CDS KLTH0E08030g 255715091 8291986 complement(737680..738540) 1 NC_013081.1 similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W; KLTH0E08030p 738540 8291986 KLTH0E08030g Lachancea thermotolerans CBS 6340 KLTH0E08030p XP_002553827.1 737680 R 559295 CDS KLTH0E08052g 255715093 8291987 739063..742779 1 NC_013081.1 similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 May be involved in depleting cytosol of Ca2 ions putative vacuolar Ca2 ATPase; KLTH0E08052p 742779 8291987 KLTH0E08052g Lachancea thermotolerans CBS 6340 KLTH0E08052p XP_002553828.1 739063 D 559295 CDS KLTH0E08074g 255715095 8291988 complement(742927..743691) 1 NC_013081.1 similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex; KLTH0E08074p 743691 8291988 KLTH0E08074g Lachancea thermotolerans CBS 6340 KLTH0E08074p XP_002553829.1 742927 R 559295 CDS KLTH0E08096g 255715097 8291989 complement(743809..745041) 1 NC_013081.1 similar to uniprot|P53196 Saccharomyces cerevisiae YGL004C RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome localized to the cytoplasm; KLTH0E08096p 745041 8291989 KLTH0E08096g Lachancea thermotolerans CBS 6340 KLTH0E08096p XP_002553830.1 743809 R 559295 CDS KLTH0E08118g 255715099 8291990 745621..747495 1 NC_013081.1 similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; KLTH0E08118p 747495 8291990 KLTH0E08118g Lachancea thermotolerans CBS 6340 KLTH0E08118p XP_002553831.1 745621 D 559295 CDS KLTH0E08140g 255715101 8291991 747649..749547 1 NC_013081.1 conserved hypothetical protein; KLTH0E08140p 749547 8291991 KLTH0E08140g Lachancea thermotolerans CBS 6340 KLTH0E08140p XP_002553832.1 747649 D 559295 CDS KLTH0E08162g 255715103 8291992 complement(749584..751254) 1 NC_013081.1 similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 CDC20 homolog 1 protein required for Clb2 and Ase1 degradation; KLTH0E08162p 751254 8291992 KLTH0E08162g Lachancea thermotolerans CBS 6340 KLTH0E08162p XP_002553833.1 749584 R 559295 CDS KLTH0E08184g 255715105 8291993 complement(751459..752772) 1 NC_013081.1 similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; KLTH0E08184p 752772 8291993 KLTH0E08184g Lachancea thermotolerans CBS 6340 KLTH0E08184p XP_002553834.1 751459 R 559295 CDS KLTH0E08206g 255715107 8291994 752883..753542 1 NC_013081.1 similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A ERP1 Protein that forms a heterotrimeric complex with Erp2p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; KLTH0E08206p 753542 8291994 KLTH0E08206g Lachancea thermotolerans CBS 6340 KLTH0E08206p XP_002553835.1 752883 D 559295 CDS KLTH0E08228g 255715109 8291995 complement(753687..755018) 1 NC_013081.1 weakly similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC) functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP potential Cdc28p substrate; KLTH0E08228p 755018 8291995 KLTH0E08228g Lachancea thermotolerans CBS 6340 KLTH0E08228p XP_002553836.1 753687 R 559295 CDS KLTH0E08272g 255715111 8291997 complement(join(756153..759562,759623..759689)) 1 NC_013081.1 similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; KLTH0E08272p 759689 8291997 KLTH0E08272g Lachancea thermotolerans CBS 6340 KLTH0E08272p XP_002553837.1 756153 R 559295 CDS KLTH0E08294g 255715113 8291998 join(759878..759894,759951..760701) 1 NC_013081.1 similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Protein with similarity to methyltransferase family members; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; KLTH0E08294p 760701 8291998 KLTH0E08294g Lachancea thermotolerans CBS 6340 KLTH0E08294p XP_002553838.1 759878 D 559295 CDS KLTH0E08338g 255715115 8292000 761420..762475 1 NC_013081.1 highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; KLTH0E08338p 762475 8292000 KLTH0E08338g Lachancea thermotolerans CBS 6340 KLTH0E08338p XP_002553839.1 761420 D 559295 CDS KLTH0E08360g 255715117 8292001 complement(762740..766468) 1 NC_013081.1 similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine- rich region that conforms to the H2 variant of the RING finger Zn2 binding motif.; KLTH0E08360p 766468 8292001 KLTH0E08360g Lachancea thermotolerans CBS 6340 KLTH0E08360p XP_002553840.1 762740 R 559295 CDS KLTH0E08382g 255715119 8292002 complement(join(766667..767213,767543..767622)) 1 NC_013081.1 highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta; KLTH0E08382p 767622 8292002 KLTH0E08382g Lachancea thermotolerans CBS 6340 KLTH0E08382p XP_002553841.1 766667 R 559295 CDS KLTH0E08426g 255715121 8292399 768206..769288 1 NC_013081.1 similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC; KLTH0E08426p 769288 8292399 KLTH0E08426g Lachancea thermotolerans CBS 6340 KLTH0E08426p XP_002553842.1 768206 D 559295 CDS KLTH0E08448g 255715123 8292004 complement(769865..770836) 1 NC_013081.1 similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p; KLTH0E08448p 770836 8292004 KLTH0E08448g Lachancea thermotolerans CBS 6340 KLTH0E08448p XP_002553843.1 769865 R 559295 CDS KLTH0E08470g 255715125 8292005 770949..773513 1 NC_013081.1 similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function; KLTH0E08470p 773513 8292005 KLTH0E08470g Lachancea thermotolerans CBS 6340 KLTH0E08470p XP_002553844.1 770949 D 559295 CDS KLTH0E08492g 255715127 8292006 complement(773530..775734) 1 NC_013081.1 similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate; KLTH0E08492p 775734 8292006 KLTH0E08492g Lachancea thermotolerans CBS 6340 KLTH0E08492p XP_002553845.1 773530 R 559295 CDS KLTH0E08514g 255715129 8292007 775783..780129 1 NC_013081.1 weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; KLTH0E08514p 780129 8292007 KLTH0E08514g Lachancea thermotolerans CBS 6340 KLTH0E08514p XP_002553846.1 775783 D 559295 CDS KLTH0E08536g 255715131 8292008 complement(780265..781641) 1 NC_013081.1 similar to uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex; KLTH0E08536p 781641 8292008 KLTH0E08536g Lachancea thermotolerans CBS 6340 KLTH0E08536p XP_002553847.1 780265 R 559295 CDS KLTH0E08558g 255715133 8292009 781814..783994 1 NC_013081.1 similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W; KLTH0E08558p 783994 8292009 KLTH0E08558g Lachancea thermotolerans CBS 6340 KLTH0E08558p XP_002553848.1 781814 D 559295 CDS KLTH0E08580g 255715135 8292010 complement(784018..784770) 1 NC_013081.1 similar to uniprot|P53769 Saccharomyces cerevisiae YLR323C; KLTH0E08580p 784770 8292010 KLTH0E08580g Lachancea thermotolerans CBS 6340 KLTH0E08580p XP_002553849.1 784018 R 559295 CDS KLTH0E08602g 255715137 8292011 784893..786461 1 NC_013081.1 similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; KLTH0E08602p 786461 8292011 KLTH0E08602g Lachancea thermotolerans CBS 6340 KLTH0E08602p XP_002553850.1 784893 D 559295 CDS KLTH0E08624g 255715139 8292012 complement(786589..786825) 1 NC_013081.1 highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit; KLTH0E08624p 786825 8292012 KLTH0E08624g Lachancea thermotolerans CBS 6340 KLTH0E08624p XP_002553851.1 786589 R 559295 CDS KLTH0E08646g 255715141 8292013 complement(787085..788233) 1 NC_013081.1 similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit; KLTH0E08646p 788233 8292013 KLTH0E08646g Lachancea thermotolerans CBS 6340 KLTH0E08646p XP_002553852.1 787085 R 559295 CDS KLTH0E08668g 255715143 8292014 788363..789160 1 NC_013081.1 weakly similar to uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p; KLTH0E08668p 789160 8292014 KLTH0E08668g Lachancea thermotolerans CBS 6340 KLTH0E08668p XP_002553853.1 788363 D 559295 CDS KLTH0E08690g 255715145 8292015 join(789261..789360,789429..790081) 1 NC_013081.1 similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF; KLTH0E08690p 790081 8292015 KLTH0E08690g Lachancea thermotolerans CBS 6340 KLTH0E08690p XP_002553854.1 789261 D 559295 CDS KLTH0E08712g 255715147 8292016 790185..791213 1 NC_013081.1 similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase; KLTH0E08712p 791213 8292016 KLTH0E08712g Lachancea thermotolerans CBS 6340 KLTH0E08712p XP_002553855.1 790185 D 559295 CDS KLTH0E08734g 255715149 8292017 complement(791406..791666) 1 NC_013081.1 similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF and YGR008C uniprot|P16965 Saccharomyces cerevisiae YGR008C STF2 ATPase stabilizing factor; KLTH0E08734p 791666 8292017 KLTH0E08734g Lachancea thermotolerans CBS 6340 KLTH0E08734p XP_002553856.1 791406 R 559295 CDS KLTH0E08756g 255715151 8292018 793960..795327 1 NC_013081.1 highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD( ) salvage pathway; KLTH0E08756p 795327 8292018 KLTH0E08756g Lachancea thermotolerans CBS 6340 KLTH0E08756p XP_002553857.1 793960 D 559295 CDS KLTH0E08778g 255715153 8292019 complement(795841..798462) 1 NC_013081.1 conserved hypothetical protein; KLTH0E08778p 798462 8292019 KLTH0E08778g Lachancea thermotolerans CBS 6340 KLTH0E08778p XP_002553858.1 795841 R 559295 CDS KLTH0E08800g 255715155 8292020 800464..801639 1 NC_013081.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF; KLTH0E08800p 801639 8292020 KLTH0E08800g Lachancea thermotolerans CBS 6340 KLTH0E08800p XP_002553859.1 800464 D 559295 CDS KLTH0E08822g 255715157 8292021 801917..803599 1 NC_013081.1 weakly similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein; KLTH0E08822p 803599 8292021 KLTH0E08822g Lachancea thermotolerans CBS 6340 KLTH0E08822p XP_002553860.1 801917 D 559295 CDS KLTH0E08844g 255715159 8292022 804120..808682 1 NC_013081.1 some similarities with uniprot|P32334 Saccharomyces cerevisiae YGR014W MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate; KLTH0E08844p 808682 8292022 KLTH0E08844g Lachancea thermotolerans CBS 6340 KLTH0E08844p XP_002553861.1 804120 D 559295 CDS KLTH0E08866g 255715161 8292023 complement(808794..809726) 1 NC_013081.1 similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF; KLTH0E08866p 809726 8292023 KLTH0E08866g Lachancea thermotolerans CBS 6340 KLTH0E08866p XP_002553862.1 808794 R 559295 CDS KLTH0E08888g 255715163 8292024 809947..810522 1 NC_013081.1 weakly similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF; KLTH0E08888p 810522 8292024 KLTH0E08888g Lachancea thermotolerans CBS 6340 KLTH0E08888p XP_002553863.1 809947 D 559295 CDS KLTH0E08954g 255715165 8292027 812397..814322 1 NC_013081.1 similar to uniprot|P54074 Saccharomyces cerevisiae YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase genetic interactions suggest a role in negative regulation of amino acid uptake; KLTH0E08954p 814322 8292027 KLTH0E08954g Lachancea thermotolerans CBS 6340 KLTH0E08954p XP_002553864.1 812397 D 559295 CDS KLTH0E08976g 255715167 8292028 complement(814709..814993) 1 NC_013081.1 conserved hypothetical protein; KLTH0E08976p 814993 8292028 KLTH0E08976g Lachancea thermotolerans CBS 6340 KLTH0E08976p XP_002553865.1 814709 R 559295 CDS KLTH0E08998g 255715169 8292029 complement(815169..816944) 1 NC_013081.1 highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4- carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities isozyme of Ade16p ade16 ade17 mutants require adenine and histidine; KLTH0E08998p 816944 8292029 KLTH0E08998g Lachancea thermotolerans CBS 6340 KLTH0E08998p XP_002553866.1 815169 R 559295 CDS KLTH0E09020g 255715171 8292030 complement(818579..819193) 1 NC_013081.1 highly similar to uniprot|P54780 Saccharomyces cerevisiae RPL15B and to uniprot|P05748 Saccharomyces cerevisiae YLR029C RPL15A; KLTH0E09020p 819193 8292030 KLTH0E09020g Lachancea thermotolerans CBS 6340 KLTH0E09020p XP_002553867.1 818579 R 559295 CDS KLTH0E09042g 255715173 8292031 820687..821139 1 NC_013081.1 conserved hypothetical protein; KLTH0E09042p 821139 8292031 KLTH0E09042g Lachancea thermotolerans CBS 6340 KLTH0E09042p XP_002553868.1 820687 D 559295 CDS KLTH0E09064g 255715175 8292032 821861..822340 1 NC_013081.1 some similarities with uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A; KLTH0E09064p 822340 8292032 KLTH0E09064g Lachancea thermotolerans CBS 6340 KLTH0E09064p XP_002553869.1 821861 D 559295 CDS KLTH0E09086g 255715177 8292033 822703..823062 1 NC_013081.1 similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 Protein of unknown function overproduction confers resistance to Pichia farinosa killer toxin; KLTH0E09086p 823062 8292033 KLTH0E09086g Lachancea thermotolerans CBS 6340 KLTH0E09086p XP_002553870.1 822703 D 559295 CDS KLTH0E09108g 255715179 8292034 823623..826409 1 NC_013081.1 some similarities with uniprot|P39523 Saccharomyces cerevisiae YMR124W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck; KLTH0E09108p 826409 8292034 KLTH0E09108g Lachancea thermotolerans CBS 6340 KLTH0E09108p XP_002553871.1 823623 D 559295 CDS KLTH0E09130g 255715181 8292035 join(826606..826630,826876..829439) 1 NC_013081.1 similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex interacts with Npl3p to carry poly(A) mRNA from the nucleus to the cytoplasm also involved in mRNA degradation in the nucleus orthologous to mammalian CBP80; KLTH0E09130p 829439 8292035 KLTH0E09130g Lachancea thermotolerans CBS 6340 KLTH0E09130p XP_002553872.1 826606 D 559295 CDS KLTH0E09152g 255715183 8292036 complement(829561..830628) 1 NC_013081.1 similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function deletion causes sensitivity to thermal stress; KLTH0E09152p 830628 8292036 KLTH0E09152g Lachancea thermotolerans CBS 6340 KLTH0E09152p XP_002553873.1 829561 R 559295 CDS KLTH0E09174g 255715185 8292037 830858..834304 1 NC_013081.1 similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 Single-stranded DNA-dependent ATPase involved in postreplication repair contains RING finger domain; KLTH0E09174p 834304 8292037 KLTH0E09174g Lachancea thermotolerans CBS 6340 KLTH0E09174p XP_002553874.1 830858 D 559295 CDS KLTH0E09196g 255715187 8292038 complement(834381..835325) 1 NC_013081.1 similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family; KLTH0E09196p 835325 8292038 KLTH0E09196g Lachancea thermotolerans CBS 6340 KLTH0E09196p XP_002553875.1 834381 R 559295 CDS KLTH0E09218g 255715189 8292039 835647..839408 1 NC_013081.1 similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP predominantly nucleolar in distribution required for 18S rRNA synthesis; KLTH0E09218p 839408 8292039 KLTH0E09218g Lachancea thermotolerans CBS 6340 KLTH0E09218p XP_002553876.1 835647 D 559295 CDS KLTH0E09240g 255715191 8292040 join(839763..839809,839906..841409) 1 NC_013081.1 similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Remodels the structure of chromatin complex 58KDa subunit; Chromatin Remodeling Complex subunit; KLTH0E09240p 841409 8292040 KLTH0E09240g Lachancea thermotolerans CBS 6340 KLTH0E09240p XP_002553877.1 839763 D 559295 CDS KLTH0E09262g 255715193 8292041 complement(841503..842918) 1 NC_013081.1 highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative metal transporter Nramp homolog homolog of SMF1 and SMF2; KLTH0E09262p 842918 8292041 KLTH0E09262g Lachancea thermotolerans CBS 6340 KLTH0E09262p XP_002553878.1 841503 R 559295 CDS KLTH0E09284g 255715195 8292042 843354..847163 1 NC_013081.1 similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; KLTH0E09284p 847163 8292042 KLTH0E09284g Lachancea thermotolerans CBS 6340 KLTH0E09284p XP_002553879.1 843354 D 559295 CDS KLTH0E09306g 255715197 8292043 847722..848345 1 NC_013081.1 similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Hypothetical ORF; KLTH0E09306p 848345 8292043 KLTH0E09306g Lachancea thermotolerans CBS 6340 KLTH0E09306p XP_002553880.1 847722 D 559295 CDS KLTH0E09350g 255715199 8292045 complement(849882..850130) 1 NC_013081.1 highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain required for assembly of fully active cytochrome c oxidase but not required for activity after assembly; KLTH0E09350p 850130 8292045 KLTH0E09350g Lachancea thermotolerans CBS 6340 KLTH0E09350p XP_002553881.1 849882 R 559295 CDS KLTH0E09372g 255715201 8292046 complement(850371..853364) 1 NC_013081.1 similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p involved in transcription of ribosomal protein genes and ribosomal RNA; KLTH0E09372p 853364 8292046 KLTH0E09372g Lachancea thermotolerans CBS 6340 KLTH0E09372p XP_002553882.1 850371 R 559295 CDS KLTH0E09394g 255715203 8292047 complement(853592..855160) 1 NC_013081.1 highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 RiboSome Assembly 2; KLTH0E09394p 855160 8292047 KLTH0E09394g Lachancea thermotolerans CBS 6340 KLTH0E09394p XP_002553883.1 853592 R 559295 CDS KLTH0E09416g 255715205 8292048 complement(855384..855995) 1 NC_013081.1 similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Hypothetical ORF; KLTH0E09416p 855995 8292048 KLTH0E09416g Lachancea thermotolerans CBS 6340 KLTH0E09416p XP_002553884.1 855384 R 559295 CDS KLTH0E09438g 255715207 8292049 856237..857586 1 NC_013081.1 weakly similar to uniprot|P32841 Saccharomyces cerevisiae YMR133W REC114 Protein involved in early stages of meiotic recombination possibly involved in the coordination of recombination and meiotic division mutations lead to premature initiation of the first meiotic division; KLTH0E09438p 857586 8292049 KLTH0E09438g Lachancea thermotolerans CBS 6340 KLTH0E09438p XP_002553885.1 856237 D 559295 CDS KLTH0E09460g 255715209 8292050 complement(857811..858581) 1 NC_013081.1 conserved hypothetical protein; KLTH0E09460p 858581 8292050 KLTH0E09460g Lachancea thermotolerans CBS 6340 KLTH0E09460p XP_002553886.1 857811 R 559295 CDS KLTH0E09482g 255715211 8292051 859339..860070 1 NC_013081.1 similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein required for cell viability; KLTH0E09482p 860070 8292051 KLTH0E09482g Lachancea thermotolerans CBS 6340 KLTH0E09482p XP_002553887.1 859339 D 559295 CDS KLTH0E09504g 255715213 8292052 complement(860113..861270) 1 NC_013081.1 similar to uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains LisH and CTLH domains like Vid30p; KLTH0E09504p 861270 8292052 KLTH0E09504g Lachancea thermotolerans CBS 6340 KLTH0E09504p XP_002553888.1 860113 R 559295 CDS KLTH0E09526g 255715215 8292053 861720..862328 1 NC_013081.1 no similarity; KLTH0E09526p 862328 8292053 KLTH0E09526g Lachancea thermotolerans CBS 6340 KLTH0E09526p XP_002553889.1 861720 D 559295 CDS KLTH0E09548g 255715217 8292054 862710..864221 1 NC_013081.1 weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2; KLTH0E09548p 864221 8292054 KLTH0E09548g Lachancea thermotolerans CBS 6340 KLTH0E09548p XP_002553890.1 862710 D 559295 CDS KLTH0E09570g 255715219 8292055 complement(864260..866047) 1 NC_013081.1 similar to uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives induced by UV- irradiation; KLTH0E09570p 866047 8292055 KLTH0E09570g Lachancea thermotolerans CBS 6340 KLTH0E09570p XP_002553891.1 864260 R 559295 CDS KLTH0E09592g 255715221 8292056 866139..866738 1 NC_013081.1 similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl; KLTH0E09592p 866738 8292056 KLTH0E09592g Lachancea thermotolerans CBS 6340 KLTH0E09592p XP_002553892.1 866139 D 559295 CDS KLTH0E09614g 255715223 8292057 867211..868224 1 NC_013081.1 similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the glyoxylate cycle; KLTH0E09614p 868224 8292057 KLTH0E09614g Lachancea thermotolerans CBS 6340 KLTH0E09614p XP_002553893.1 867211 D 559295 CDS KLTH0E09636g 255715225 8292058 868703..869083 1 NC_013081.1 conserved hypothetical protein; KLTH0E09636p 869083 8292058 KLTH0E09636g Lachancea thermotolerans CBS 6340 KLTH0E09636p XP_002553894.1 868703 D 559295 CDS KLTH0E09658g 255715227 8292059 869857..870957 1 NC_013081.1 highly similar to uniprot|P38615 Saccharomyces cerevisiae YMR139W; KLTH0E09658p 870957 8292059 KLTH0E09658g Lachancea thermotolerans CBS 6340 KLTH0E09658p XP_002553895.1 869857 D 559295 CDS KLTH0E09680g 255715229 8292060 complement(871598..872680) 1 NC_013081.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W or uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 NADPH-dependent methylglyoxal reductase; KLTH0E09680p 872680 8292060 KLTH0E09680g Lachancea thermotolerans CBS 6340 KLTH0E09680p XP_002553896.1 871598 R 559295 CDS KLTH0E09702g 255715231 8292061 874177..876000 1 NC_013081.1 similar to uniprot|Q07471 Saccharomyces cerevisiae YDL080C THI3 Probable decarboxylase required for expression of enzymes involved in thiamine biosynthesis may have a role in catabolism of amino acids to long-chain and complex alcohols; KLTH0E09702p 876000 8292061 KLTH0E09702g Lachancea thermotolerans CBS 6340 KLTH0E09702p XP_002553897.1 874177 D 559295 CDS KLTH0E09724g 255715233 8292062 876916..879222 1 NC_013081.1 weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance; KLTH0E09724p 879222 8292062 KLTH0E09724g Lachancea thermotolerans CBS 6340 KLTH0E09724p XP_002553898.1 876916 D 559295 CDS KLTH0E09746g 255715235 8292063 879520..880329 1 NC_013081.1 similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Hypothetical ORF; KLTH0E09746p 880329 8292063 KLTH0E09746g Lachancea thermotolerans CBS 6340 KLTH0E09746p XP_002553899.1 879520 D 559295 CDS KLTH0E09768g 255715237 8292064 complement(880368..881126) 1 NC_013081.1 similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; KLTH0E09768p 881126 8292064 KLTH0E09768g Lachancea thermotolerans CBS 6340 KLTH0E09768p XP_002553900.1 880368 R 559295 CDS KLTH0E09790g 255715239 8292065 881284..883152 1 NC_013081.1 similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization able to recruit actin polymerization machinery through its SH3 domains colocalizes with cortical actin patches and Las17p interacts with type I myosins; KLTH0E09790p 883152 8292065 KLTH0E09790g Lachancea thermotolerans CBS 6340 KLTH0E09790p XP_002553901.1 881284 D 559295 CDS KLTH0E09812g 255715241 8292066 883517..885331 1 NC_013081.1 similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Hypothetical ORF; KLTH0E09812p 885331 8292066 KLTH0E09812g Lachancea thermotolerans CBS 6340 KLTH0E09812p XP_002553902.1 883517 D 559295 CDS KLTH0E09834g 255715243 8292067 complement(885503..886942) 1 NC_013081.1 some similarities with uniprot|P53924 Saccharomyces cerevisiae YNL116W DMA2 Protein involved in regulating spindle position and orientation functionally redundant with Dma1p homolog of S. pombe Dma1 and H. sapiens Chfr; KLTH0E09834p 886942 8292067 KLTH0E09834g Lachancea thermotolerans CBS 6340 KLTH0E09834p XP_002553903.1 885503 R 559295 CDS KLTH0E09856g 255715245 8292068 complement(888231..889949) 1 NC_013081.1 highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase enzyme of the glyoxylate cycle involved in utilization of non- fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium; KLTH0E09856p 889949 8292068 KLTH0E09856g Lachancea thermotolerans CBS 6340 KLTH0E09856p XP_002553904.1 888231 R 559295 CDS KLTH0E09878g 255715247 8292069 891051..892604 1 NC_013081.1 similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis; KLTH0E09878p 892604 8292069 KLTH0E09878g Lachancea thermotolerans CBS 6340 KLTH0E09878p XP_002553905.1 891051 D 559295 CDS KLTH0E09900g 255715249 8292070 892910..893932 1 NC_013081.1 similar to uniprot|P47181 Saccharomyces cerevisiae YJR154W Hypothetical ORF; KLTH0E09900p 893932 8292070 KLTH0E09900g Lachancea thermotolerans CBS 6340 KLTH0E09900p XP_002553906.1 892910 D 559295 CDS KLTH0E09922g 255715251 8292071 894838..898197 1 NC_013081.1 weakly similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization; KLTH0E09922p 898197 8292071 KLTH0E09922g Lachancea thermotolerans CBS 6340 KLTH0E09922p XP_002553907.1 894838 D 559295 CDS KLTH0E09944g 255715253 8292072 complement(898345..901746) 1 NC_013081.1 weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein required for cell-cycle arrest in G1/S intra-S and G2/M transmits checkpoint signal by activating Rad53p and Chk1p hyperphosphorylated by Mec1p and Tel1p potential Cdc28p substrate; KLTH0E09944p 901746 8292072 KLTH0E09944g Lachancea thermotolerans CBS 6340 KLTH0E09944p XP_002553908.1 898345 R 559295 CDS KLTH0E09966g 255715255 8292073 902112..903407 1 NC_013081.1 weakly similar to uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Component of the meiotic outer plaque a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; KLTH0E09966p 903407 8292073 KLTH0E09966g Lachancea thermotolerans CBS 6340 KLTH0E09966p XP_002553909.1 902112 D 559295 CDS KLTH0E09988g 255715257 8292074 complement(903764..904918) 1 NC_013081.1 similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II; KLTH0E09988p 904918 8292074 KLTH0E09988g Lachancea thermotolerans CBS 6340 KLTH0E09988p XP_002553910.1 903764 R 559295 CDS KLTH0E10010g 255715259 8292075 complement(905166..906518) 1 NC_013081.1 weakly similar to uniprot|Q04922 Saccharomyces cerevisiae YDR219C Hypothetical ORF; KLTH0E10010p 906518 8292075 KLTH0E10010g Lachancea thermotolerans CBS 6340 KLTH0E10010p XP_002553911.1 905166 R 559295 CDS KLTH0E10032g 255715261 8292076 complement(907638..908537) 1 NC_013081.1 weakly similar to uniprot|Q2JVJ5 Yellowstone A- Prime CYA_1049 NAD-dependent epimerase/dehydratase family protein; KLTH0E10032p 908537 8292076 KLTH0E10032g Lachancea thermotolerans CBS 6340 KLTH0E10032p XP_002553912.1 907638 R 559295 CDS KLTH0E10054g 255715263 8292077 909503..911500 1 NC_013081.1 similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W Hypothetical ORF; KLTH0E10054p 911500 8292077 KLTH0E10054g Lachancea thermotolerans CBS 6340 KLTH0E10054p XP_002553913.1 909503 D 559295 CDS KLTH0E10076g 255715265 8292078 911651..912847 1 NC_013081.1 similar to uniprot|Q04925 Saccharomyces cerevisiae YDR222W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0E10076p 912847 8292078 KLTH0E10076g Lachancea thermotolerans CBS 6340 KLTH0E10076p XP_002553914.1 911651 D 559295 CDS KLTH0E10098g 255715267 8292079 913351..916224 1 NC_013081.1 weakly similar to uniprot|P39520 Saccharomyces cerevisiae YLR223C IFH1 Essential protein with a highly acidic N-terminal domain IFH1 exhibits genetic interactions with FHL1 overexpression interferes with silencing at telomeres and HM loci potential Cdc28p substrate; KLTH0E10098p 916224 8292079 KLTH0E10098g Lachancea thermotolerans CBS 6340 KLTH0E10098p XP_002553915.1 913351 D 559295 CDS KLTH0E10120g 255715269 8292080 916575..919055 1 NC_013081.1 highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0E10120p 919055 8292080 KLTH0E10120g Lachancea thermotolerans CBS 6340 KLTH0E10120p XP_002553916.1 916575 D 559295 CDS KLTH0E10142g 255715271 8292081 919203..919778 1 NC_013081.1 some similarities with uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation required for accumulation of wild- type levels of large (60S) ribosomal subunits binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus; KLTH0E10142p 919778 8292081 KLTH0E10142g Lachancea thermotolerans CBS 6340 KLTH0E10142p XP_002553917.1 919203 D 559295 CDS KLTH0E10164g 255715273 8292082 complement(919912..920781) 1 NC_013081.1 similar to uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Functions in the homeostasis of both calcium and manganese ions Possible transmembrane Ca2 transporter; KLTH0E10164p 920781 8292082 KLTH0E10164g Lachancea thermotolerans CBS 6340 KLTH0E10164p XP_002553918.1 919912 R 559295 CDS KLTH0E10186g 255715275 8292083 complement(921612..922010) 1 NC_013081.1 similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; KLTH0E10186p 922010 8292083 KLTH0E10186g Lachancea thermotolerans CBS 6340 KLTH0E10186p XP_002553919.1 921612 R 559295 CDS KLTH0E10208g 255715277 8292084 922568..922963 1 NC_013081.1 similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; KLTH0E10208p 922963 8292084 KLTH0E10208g Lachancea thermotolerans CBS 6340 KLTH0E10208p XP_002553920.1 922568 D 559295 CDS KLTH0E10230g 255715279 8292085 complement(923078..924721) 1 NC_013081.1 weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids potential Cdc28p substrate; KLTH0E10230p 924721 8292085 KLTH0E10230g Lachancea thermotolerans CBS 6340 KLTH0E10230p XP_002553921.1 923078 R 559295 CDS KLTH0E10274g 255715281 8292087 926587..927270 1 NC_013081.1 highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 adenylate kinase; KLTH0E10274p 927270 8292087 KLTH0E10274g Lachancea thermotolerans CBS 6340 KLTH0E10274p XP_002553922.1 926587 D 559295 CDS KLTH0E10296g 255715283 8292088 927506..932128 1 NC_013081.1 conserved hypothetical protein; KLTH0E10296p 932128 8292088 KLTH0E10296g Lachancea thermotolerans CBS 6340 KLTH0E10296p XP_002553923.1 927506 D 559295 CDS KLTH0E10318g 255715285 8292089 complement(932380..934125) 1 NC_013081.1 some similarities with uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor essential component of cleavage and polyadenylation factor IA (CF IA) involved in pre-mRNA 3' end processing and in transcription termination binds C- terminal domain of largest subunit of RNA pol II (Rpo21p); KLTH0E10318p 934125 8292089 KLTH0E10318g Lachancea thermotolerans CBS 6340 KLTH0E10318p XP_002553924.1 932380 R 559295 CDS KLTH0E10340g 255715287 8292090 934782..935771 1 NC_013081.1 highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family (putative) mitochondrial carrier protein; KLTH0E10340p 935771 8292090 KLTH0E10340g Lachancea thermotolerans CBS 6340 KLTH0E10340p XP_002553925.1 934782 D 559295 CDS KLTH0E10362g 255715289 8292091 complement(935955..936980) 1 NC_013081.1 conserved hypothetical protein; KLTH0E10362p 936980 8292091 KLTH0E10362g Lachancea thermotolerans CBS 6340 KLTH0E10362p XP_002553926.1 935955 R 559295 CDS KLTH0E10384g 255715291 8292092 937342..938157 1 NC_013081.1 no similarity; KLTH0E10384p 938157 8292092 KLTH0E10384g Lachancea thermotolerans CBS 6340 KLTH0E10384p XP_002553927.1 937342 D 559295 CDS KLTH0E10406g 255715293 8292093 938423..940624 1 NC_013081.1 weakly similar to uniprot|Q12407 Saccharomyces cerevisiae YDL199C Hypothetical ORF; KLTH0E10406p 940624 8292093 KLTH0E10406g Lachancea thermotolerans CBS 6340 KLTH0E10406p XP_002553928.1 938423 D 559295 CDS KLTH0E10428g 255715295 8292094 complement(940734..941585) 1 NC_013081.1 highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA; KLTH0E10428p 941585 8292094 KLTH0E10428g Lachancea thermotolerans CBS 6340 KLTH0E10428p XP_002553929.1 940734 R 559295 CDS KLTH0E10450g 255715297 8292095 complement(942374..943063) 1 NC_013081.1 similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit; KLTH0E10450p 943063 8292095 KLTH0E10450g Lachancea thermotolerans CBS 6340 KLTH0E10450p XP_002553930.1 942374 R 559295 CDS KLTH0E10472g 255715299 8292096 944027..945346 1 NC_013081.1 similar to uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase; KLTH0E10472p 945346 8292096 KLTH0E10472g Lachancea thermotolerans CBS 6340 KLTH0E10472p XP_002553931.1 944027 D 559295 CDS KLTH0E10494g 255715301 8292097 complement(945467..946021) 1 NC_013081.1 similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; KLTH0E10494p 946021 8292097 KLTH0E10494g Lachancea thermotolerans CBS 6340 KLTH0E10494p XP_002553932.1 945467 R 559295 CDS KLTH0E10516g 255715303 8292098 946506..948404 1 NC_013081.1 similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF; KLTH0E10516p 948404 8292098 KLTH0E10516g Lachancea thermotolerans CBS 6340 KLTH0E10516p XP_002553933.1 946506 D 559295 CDS KLTH0E10538g 255715305 8292099 948937..950628 1 NC_013081.1 similar to uniprot|P09950 Saccharomyces cerevisiae YDR232W HEM1 5-aminolevulinate synthase catalyzes the first step in the heme biosynthetic pathway an N-terminal signal sequence is required for localization to the mitochondrial matrix expression is regulated by Hap2p- Hap3p; KLTH0E10538p 950628 8292099 KLTH0E10538g Lachancea thermotolerans CBS 6340 KLTH0E10538p XP_002553934.1 948937 D 559295 CDS KLTH0E10560g 255715307 8292100 complement(951130..952062) 1 NC_013081.1 similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon- like A) subfamily; KLTH0E10560p 952062 8292100 KLTH0E10560g Lachancea thermotolerans CBS 6340 KLTH0E10560p XP_002553935.1 951130 R 559295 CDS KLTH0E10582g 255715309 8292101 953799..955862 1 NC_013081.1 highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway; KLTH0E10582p 955862 8292101 KLTH0E10582g Lachancea thermotolerans CBS 6340 KLTH0E10582p XP_002553936.1 953799 D 559295 CDS KLTH0E10604g 255715311 8292102 956536..957546 1 NC_013081.1 similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p; KLTH0E10604p 957546 8292102 KLTH0E10604g Lachancea thermotolerans CBS 6340 KLTH0E10604p XP_002553937.1 956536 D 559295 CDS KLTH0E10626g 255715313 8292103 957868..959472 1 NC_013081.1 similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats; KLTH0E10626p 959472 8292103 KLTH0E10626g Lachancea thermotolerans CBS 6340 KLTH0E10626p XP_002553938.1 957868 D 559295 CDS KLTH0E10648g 255715315 8292104 complement(959492..961513) 1 NC_013081.1 weakly similar to uniprot|Q12424 Saccharomyces cerevisiae YDL206W Hypothetical ORF; KLTH0E10648p 961513 8292104 KLTH0E10648g Lachancea thermotolerans CBS 6340 KLTH0E10648p XP_002553939.1 959492 R 559295 CDS KLTH0E10670g 255715317 8292105 complement(961638..962192) 1 NC_013081.1 similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane; KLTH0E10670p 962192 8292105 KLTH0E10670g Lachancea thermotolerans CBS 6340 KLTH0E10670p XP_002553940.1 961638 R 559295 CDS KLTH0E10692g 255715319 8292106 complement(962373..963941) 1 NC_013081.1 some similarities with uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal; KLTH0E10692p 963941 8292106 KLTH0E10692g Lachancea thermotolerans CBS 6340 KLTH0E10692p XP_002553941.1 962373 R 559295 CDS KLTH0E10714g 255715321 8292107 964199..965068 1 NC_013081.1 highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit; KLTH0E10714p 965068 8292107 KLTH0E10714g Lachancea thermotolerans CBS 6340 KLTH0E10714p XP_002553942.1 964199 D 559295 CDS KLTH0E10736g 255715323 8292108 complement(965155..968076) 1 NC_013081.1 highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer; KLTH0E10736p 968076 8292108 KLTH0E10736g Lachancea thermotolerans CBS 6340 KLTH0E10736p XP_002553943.1 965155 R 559295 CDS KLTH0E10758g 255715325 8292109 complement(968291..970429) 1 NC_013081.1 weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF; KLTH0E10758p 970429 8292109 KLTH0E10758g Lachancea thermotolerans CBS 6340 KLTH0E10758p XP_002553944.1 968291 R 559295 CDS KLTH0E10780g 255715327 8292110 complement(970692..972044) 1 NC_013081.1 weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP; KLTH0E10780p 972044 8292110 KLTH0E10780g Lachancea thermotolerans CBS 6340 KLTH0E10780p XP_002553945.1 970692 R 559295 CDS KLTH0E10802g 255715329 8292111 complement(972349..972798) 1 NC_013081.1 similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing; KLTH0E10802p 972798 8292111 KLTH0E10802g Lachancea thermotolerans CBS 6340 KLTH0E10802p XP_002553946.1 972349 R 559295 CDS KLTH0E10824g 255715331 8292112 973337..975079 1 NC_013081.1 similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation; KLTH0E10824p 975079 8292112 KLTH0E10824g Lachancea thermotolerans CBS 6340 KLTH0E10824p XP_002553947.1 973337 D 559295 CDS KLTH0E10868g 255715333 8292114 975831..976856 1 NC_013081.1 similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C; KLTH0E10868p 976856 8292114 KLTH0E10868g Lachancea thermotolerans CBS 6340 KLTH0E10868p XP_002553948.1 975831 D 559295 CDS KLTH0E10890g 255715335 8292115 complement(976948..978717) 1 NC_013081.1 similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site; KLTH0E10890p 978717 8292115 KLTH0E10890g Lachancea thermotolerans CBS 6340 KLTH0E10890p XP_002553949.1 976948 R 559295 CDS KLTH0E10912g 255715337 8292116 980341..981681 1 NC_013081.1 conserved hypothetical protein; KLTH0E10912p 981681 8292116 KLTH0E10912g Lachancea thermotolerans CBS 6340 KLTH0E10912p XP_002553950.1 980341 D 559295 CDS KLTH0E10934g 255715339 8292117 981831..983537 1 NC_013081.1 similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL- like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR); KLTH0E10934p 983537 8292117 KLTH0E10934g Lachancea thermotolerans CBS 6340 KLTH0E10934p XP_002553951.1 981831 D 559295 CDS KLTH0E10956g 255715341 8292118 983664..984677 1 NC_013081.1 similar to uniprot|P50108 Saccharomyces cerevisiae YDR245W MNN10 Subunit of a Golgi mannosyltransferase complex also containing Anp1p Mnn9p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone membrane protein of the mannosyltransferase family; KLTH0E10956p 984677 8292118 KLTH0E10956g Lachancea thermotolerans CBS 6340 KLTH0E10956p XP_002553952.1 983664 D 559295 CDS KLTH0E10978g 255715343 8292119 984997..988311 1 NC_013081.1 some similarities with uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Global transcription activator that acts in complex with Snf2p Snf5p Snf6p and Swi3p to assist gene-specific activators involved in the regulation of expression of many genes including ADH1 ADH2 GAL1 HO INO1 and SUC2 Zinc-finger transcription factor; KLTH0E10978p 988311 8292119 KLTH0E10978g Lachancea thermotolerans CBS 6340 KLTH0E10978p XP_002553953.1 984997 D 559295 CDS KLTH0E11000g 255715345 8292120 complement(988370..991429) 1 NC_013081.1 similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease; KLTH0E11000p 991429 8292120 KLTH0E11000g Lachancea thermotolerans CBS 6340 KLTH0E11000p XP_002553954.1 988370 R 559295 CDS KLTH0E11022g 255715347 8292121 991530..993512 1 NC_013081.1 similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10- methylenetetrahydrofolate to 5- methyltetrahydrofolate in the methionine biosynthesis pathway; KLTH0E11022p 993512 8292121 KLTH0E11022g Lachancea thermotolerans CBS 6340 KLTH0E11022p XP_002553955.1 991530 D 559295 CDS KLTH0E11044g 255715349 8292122 complement(993574..994401) 1 NC_013081.1 similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Protein of unknown function GFP tagged protein localizes to the cytoplasm and nucleus; KLTH0E11044p 994401 8292122 KLTH0E11044g Lachancea thermotolerans CBS 6340 KLTH0E11044p XP_002553956.1 993574 R 559295 CDS KLTH0E11066g 255715351 8292123 994414..994989 1 NC_013081.1 similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; KLTH0E11066p 994989 8292123 KLTH0E11066g Lachancea thermotolerans CBS 6340 KLTH0E11066p XP_002553957.1 994414 D 559295 CDS KLTH0E11088g 255715353 8292124 995403..996608 1 NC_013081.1 conserved hypothetical protein; KLTH0E11088p 996608 8292124 KLTH0E11088g Lachancea thermotolerans CBS 6340 KLTH0E11088p XP_002553958.1 995403 D 559295 CDS KLTH0E11110g 255715355 8292125 997486..998847 1 NC_013081.1 similar to uniprot|Q12505 Saccharomyces cerevisiae YPL026C SKS1 multicopy suppressor of snf3 and grr1 mutants serine/threonine protein kinase homologous to Ran1p; KLTH0E11110p 998847 8292125 KLTH0E11110g Lachancea thermotolerans CBS 6340 KLTH0E11110p XP_002553959.1 997486 D 559295 CDS KLTH0E11132g 255715357 8292126 complement(999078..999644) 1 NC_013081.1 similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Hypothetical ORF; KLTH0E11132p 999644 8292126 KLTH0E11132g Lachancea thermotolerans CBS 6340 KLTH0E11132p XP_002553960.1 999078 R 559295 CDS KLTH0E11154g 255715359 8292127 complement(999926..1001116) 1 NC_013081.1 highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis; KLTH0E11154p 1001116 8292127 KLTH0E11154g Lachancea thermotolerans CBS 6340 KLTH0E11154p XP_002553961.1 999926 R 559295 CDS KLTH0E11176g 255715361 8292128 complement(1001391..1003625) 1 NC_013081.1 similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase component of the mitochondrial degradosome; KLTH0E11176p 1003625 8292128 KLTH0E11176g Lachancea thermotolerans CBS 6340 KLTH0E11176p XP_002553962.1 1001391 R 559295 CDS KLTH0E11198g 255715363 8292129 complement(1003858..1005456) 1 NC_013081.1 similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W Hypothetical ORF; KLTH0E11198p 1005456 8292129 KLTH0E11198g Lachancea thermotolerans CBS 6340 KLTH0E11198p XP_002553963.1 1003858 R 559295 CDS KLTH0E11220g 255715365 8292130 join(1005953..1005969,1006040..1006931) 1 NC_013081.1 highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase with ten cyclin partners involved in environmental stress response in phosphate-rich conditions Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5; KLTH0E11220p 1006931 8292130 KLTH0E11220g Lachancea thermotolerans CBS 6340 KLTH0E11220p XP_002553964.1 1005953 D 559295 CDS KLTH0E11242g 255715367 8292131 complement(1006981..1008075) 1 NC_013081.1 weakly similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Hypothetical ORF; KLTH0E11242p 1008075 8292131 KLTH0E11242g Lachancea thermotolerans CBS 6340 KLTH0E11242p XP_002553965.1 1006981 R 559295 CDS KLTH0E11264g 255715369 8292132 1008309..1010897 1 NC_013081.1 similar to uniprot|Q03088 Saccharomyces cerevisiae YPL032C SVL3 Protein of unknown function mutant phenotype suggests a potential role in vacuolar function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck; KLTH0E11264p 1010897 8292132 KLTH0E11264g Lachancea thermotolerans CBS 6340 KLTH0E11264p XP_002553966.1 1008309 D 559295 CDS KLTH0E11308g 255715371 8292134 1012290..1012778 1 NC_013081.1 similar to uniprot|P40314 Saccharomyces cerevisiae YDR252W BTT1; KLTH0E11308p 1012778 8292134 KLTH0E11308g Lachancea thermotolerans CBS 6340 KLTH0E11308p XP_002553967.1 1012290 D 559295 CDS KLTH0E11330g 255715373 8292135 complement(1013019..1013618) 1 NC_013081.1 similar to uniprot|Q12041 Saccharomyces cerevisiae YDR253C MET32 Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes; KLTH0E11330p 1013618 8292135 KLTH0E11330g Lachancea thermotolerans CBS 6340 KLTH0E11330p XP_002553968.1 1013019 R 559295 CDS KLTH0E11352g 255715375 8292136 1014490..1017447 1 NC_013081.1 similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase null mutant is deficient in respiratory growth; KLTH0E11352p 1017447 8292136 KLTH0E11352g Lachancea thermotolerans CBS 6340 KLTH0E11352p XP_002553969.1 1014490 D 559295 CDS KLTH0E11374g 255715377 8292137 1017534..1018184 1 NC_013081.1 some similarities with uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Hypothetical ORF; KLTH0E11374p 1018184 8292137 KLTH0E11374g Lachancea thermotolerans CBS 6340 KLTH0E11374p XP_002553970.1 1017534 D 559295 CDS KLTH0E11396g 255715379 8292138 1018348..1020069 1 NC_013081.1 similar to uniprot|P39073 Saccharomyces cerevisiae YPL042C SSN3 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation; KLTH0E11396p 1020069 8292138 KLTH0E11396g Lachancea thermotolerans CBS 6340 KLTH0E11396p XP_002553971.1 1018348 D 559295 CDS KLTH0E11418g 255715381 8292139 complement(1020231..1022312) 1 NC_013081.1 some similarities with uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis contains four RNA recognition motifs (RRMs); KLTH0E11418p 1022312 8292139 KLTH0E11418g Lachancea thermotolerans CBS 6340 KLTH0E11418p XP_002553972.1 1020231 R 559295 CDS KLTH0E11440g 255715383 8292140 1022627..1023835 1 NC_013081.1 weakly similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein required for chromosome stability interacts with kinetochore proteins Ctf19p Ctf3p and Iml3p exhibits a two-hybrid interaction with Mif2p association with CEN DNA requires Ctf19p; KLTH0E11440p 1023835 8292140 KLTH0E11440g Lachancea thermotolerans CBS 6340 KLTH0E11440p XP_002553973.1 1022627 D 559295 CDS KLTH0E11462g 255715385 8292141 complement(1023850..1026249) 1 NC_013081.1 similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Vacuolar sorting protein; KLTH0E11462p 1026249 8292141 KLTH0E11462g Lachancea thermotolerans CBS 6340 KLTH0E11462p XP_002553974.1 1023850 R 559295 CDS KLTH0E11484g 255715387 8292142 1026368..1026661 1 NC_013081.1 similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C forms heterodimer with Ela1p that participates in transcription elongation expression dramatically upregulated during sporulation widely conserved among eukaryotes; KLTH0E11484p 1026661 8292142 KLTH0E11484g Lachancea thermotolerans CBS 6340 KLTH0E11484p XP_002553975.1 1026368 D 559295 CDS KLTH0E11506g 255715389 8292143 complement(1026687..1027895) 1 NC_013081.1 similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Cytosolic protein required for sporulation also required for the ubiquitination of the gluconeogenetic enzyme fructose-1 6-bisphosphatase which is degraded rapidly after the switch from gluconeogenesis to glycolysis; KLTH0E11506p 1027895 8292143 KLTH0E11506g Lachancea thermotolerans CBS 6340 KLTH0E11506p XP_002553976.1 1026687 R 559295 CDS KLTH0E11528g 255715391 8292144 complement(1028171..1028467) 1 NC_013081.1 similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes; KLTH0E11528p 1028467 8292144 KLTH0E11528g Lachancea thermotolerans CBS 6340 KLTH0E11528p XP_002553977.1 1028171 R 559295 CDS KLTH0E11550g 255715393 8292145 complement(1028766..1030301) 1 NC_013081.1 highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; KLTH0E11550p 1030301 8292145 KLTH0E11550g Lachancea thermotolerans CBS 6340 KLTH0E11550p XP_002553978.1 1028766 R 559295 CDS KLTH0E11572g 255715395 8292146 complement(1031665..1032918) 1 NC_013081.1 similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Translational cofactor elongation factor-1 gamma participates in the regulation of GTP- binding protein EF-1 alpha may play a redundant role in the regulation of protein synthesis or another GTP- dependent process; KLTH0E11572p 1032918 8292146 KLTH0E11572g Lachancea thermotolerans CBS 6340 KLTH0E11572p XP_002553979.1 1031665 R 559295 CDS KLTH0E11594g 255715397 8292147 1033891..1035174 1 NC_013081.1 weakly similar to uniprot|Q03063 Saccharomyces cerevisiae YPL049C DIG1 Regulatory protein of unknown function constitutively-expressed involved in the regulation of mating-specific genes and the invasive growth pathway required for MAP-kinase imposed repression inhibits pheromone-responsive transcription; KLTH0E11594p 1035174 8292147 KLTH0E11594g Lachancea thermotolerans CBS 6340 KLTH0E11594p XP_002553980.1 1033891 D 559295 CDS KLTH0E11616g 255715399 8292148 1035396..1036580 1 NC_013081.1 highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p Mnn10p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation; KLTH0E11616p 1036580 8292148 KLTH0E11616g Lachancea thermotolerans CBS 6340 KLTH0E11616p XP_002553981.1 1035396 D 559295 CDS KLTH0E11638g 255715401 8292149 complement(1036695..1038311) 1 NC_013081.1 similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible alkaline phosphatase a glycoprotein localized to the vacuole regulated by levels of inorganic phosphate and by a system consisting of Pho4p Pho9p Pho80p Pho81p and Pho85p dephosphorylates phosphotyrosyl peptides; KLTH0E11638p 1038311 8292149 KLTH0E11638g Lachancea thermotolerans CBS 6340 KLTH0E11638p XP_002553982.1 1036695 R 559295 CDS KLTH0E11660g 255715403 8292150 complement(1038583..1039245) 1 NC_013081.1 highly similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W YPL051W ARL3 GTPase of the Rassuperfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; KLTH0E11660p 1039245 8292150 KLTH0E11660g Lachancea thermotolerans CBS 6340 KLTH0E11660p XP_002553983.1 1038583 R 559295 CDS KLTH0E11682g 255715405 8292151 complement(1039413..1039817) 1 NC_013081.1 similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C; KLTH0E11682p 1039817 8292151 KLTH0E11682g Lachancea thermotolerans CBS 6340 KLTH0E11682p XP_002553984.1 1039413 R 559295 CDS KLTH0E11704g 255715407 8292152 complement(1039996..1040586) 1 NC_013081.1 some similarities with uniprot|Q02803 Saccharomyces cerevisiae YPL052W OAZ1 Regulator of ornithine decarboxylase (Spe1p) antizyme that binds to Spe1p to regulate ubiquitin-independent degradation ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin- mediated degradation are both polyamine- regulated; KLTH0E11704p 1040586 8292152 KLTH0E11704g Lachancea thermotolerans CBS 6340 KLTH0E11704p XP_002553985.1 1039996 R 559295 CDS KLTH0E11726g 255715409 8292153 1041704..1043077 1 NC_013081.1 similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation; KLTH0E11726p 1043077 8292153 KLTH0E11726g Lachancea thermotolerans CBS 6340 KLTH0E11726p XP_002553986.1 1041704 D 559295 CDS KLTH0E11748g 255715411 8292154 1043203..1044339 1 NC_013081.1 similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery; KLTH0E11748p 1044339 8292154 KLTH0E11748g Lachancea thermotolerans CBS 6340 KLTH0E11748p XP_002553987.1 1043203 D 559295 CDS KLTH0E11770g 255715413 8292155 complement(1044412..1046775) 1 NC_013081.1 similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation.; KLTH0E11770p 1046775 8292155 KLTH0E11770g Lachancea thermotolerans CBS 6340 KLTH0E11770p XP_002553988.1 1044412 R 559295 CDS KLTH0E11792g 255715415 8292156 1047925..1050339 1 NC_013081.1 similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; KLTH0E11792p 1050339 8292156 KLTH0E11792g Lachancea thermotolerans CBS 6340 KLTH0E11792p XP_002553989.1 1047925 D 559295 CDS KLTH0E11814g 255715417 8292157 complement(1050390..1051364) 1 NC_013081.1 conserved hypothetical protein; KLTH0E11814p 1051364 8292157 KLTH0E11814g Lachancea thermotolerans CBS 6340 KLTH0E11814p XP_002553990.1 1050390 R 559295 CDS KLTH0E11836g 255715419 8292158 complement(1052611..1053726) 1 NC_013081.1 some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function; KLTH0E11836p 1053726 8292158 KLTH0E11836g Lachancea thermotolerans CBS 6340 KLTH0E11836p XP_002553991.1 1052611 R 559295 CDS KLTH0E11858g 255715421 8292159 1055267..1056733 1 NC_013081.1 weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability; KLTH0E11858p 1056733 8292159 KLTH0E11858g Lachancea thermotolerans CBS 6340 KLTH0E11858p XP_002553992.1 1055267 D 559295 CDS KLTH0E11880g 255715423 8292160 join(1056945..1056968,1057173..1057703) 1 NC_013081.1 conserved hypothetical protein; KLTH0E11880p 1057703 8292160 KLTH0E11880g Lachancea thermotolerans CBS 6340 KLTH0E11880p XP_002553993.1 1056945 D 559295 CDS KLTH0E11902g 255715425 8292161 1057892..1058977 1 NC_013081.1 highly similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase; KLTH0E11902p 1058977 8292161 KLTH0E11902g Lachancea thermotolerans CBS 6340 KLTH0E11902p XP_002553994.1 1057892 D 559295 CDS KLTH0E11924g 255715427 8292162 1059134..1060030 1 NC_013081.1 highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; KLTH0E11924p 1060030 8292162 KLTH0E11924g Lachancea thermotolerans CBS 6340 KLTH0E11924p XP_002553995.1 1059134 D 559295 CDS KLTH0E11946g 255715429 8292163 1061063..1062157 1 NC_013081.1 similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C SUR1 and similar to uniprot|P38287 Saccharomyces cerevisiae YBR161W CSH1; KLTH0E11946p 1062157 8292163 KLTH0E11946g Lachancea thermotolerans CBS 6340 KLTH0E11946p XP_002553996.1 1061063 D 559295 CDS KLTH0E11968g 255715431 8292164 complement(1062815..1064206) 1 NC_013081.1 weakly similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF; KLTH0E11968p 1064206 8292164 KLTH0E11968g Lachancea thermotolerans CBS 6340 KLTH0E11968p XP_002553997.1 1062815 R 559295 CDS KLTH0E11990g 255715433 8292165 1066154..1066342 1 NC_013081.1 similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A; KLTH0E11990p 1066342 8292165 KLTH0E11990g Lachancea thermotolerans CBS 6340 KLTH0E11990p XP_002553998.1 1066154 D 559295 CDS KLTH0E12012g 255715435 8292166 1066961..1068619 1 NC_013081.1 similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W; KLTH0E12012p 1068619 8292166 KLTH0E12012g Lachancea thermotolerans CBS 6340 KLTH0E12012p XP_002553999.1 1066961 D 559295 CDS KLTH0E12034g 255715437 8292167 complement(1069449..1069859) 1 NC_013081.1 similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide- radical responsive glutathione-dependent oxidoreductase mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers monothiol glutaredoxin subfamily member along with Grx3p and Grx4p; KLTH0E12034p 1069859 8292167 KLTH0E12034g Lachancea thermotolerans CBS 6340 KLTH0E12034p XP_002554000.1 1069449 R 559295 CDS KLTH0E12078g 255715439 8292169 1070933..1076422 1 NC_013081.1 highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1 2 Urea amidolyase contains both urea carboxylase and allophanate hydrolase activities degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate an intermediate in allantoin degradation; KLTH0E12078p 1076422 8292169 KLTH0E12078g Lachancea thermotolerans CBS 6340 KLTH0E12078p XP_002554001.1 1070933 D 559295 CDS KLTH0E12100g 255715441 8292170 complement(1076525..1077838) 1 NC_013081.1 similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis; KLTH0E12100p 1077838 8292170 KLTH0E12100g Lachancea thermotolerans CBS 6340 KLTH0E12100p XP_002554002.1 1076525 R 559295 CDS KLTH0E12122g 255715443 8292171 complement(1078116..1079381) 1 NC_013081.1 similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W LPE10 Mitochondrial inner membrane magnesium transporter involved in maintenance of magnesium concentrations inside mitochondria indirectly affects splicing of group II introns functionally and structurally related to Mrs2p; KLTH0E12122p 1079381 8292171 KLTH0E12122g Lachancea thermotolerans CBS 6340 KLTH0E12122p XP_002554003.1 1078116 R 559295 CDS KLTH0E12144g 255715445 8292172 complement(1079526..1080767) 1 NC_013081.1 similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1 2- mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; KLTH0E12144p 1080767 8292172 KLTH0E12144g Lachancea thermotolerans CBS 6340 KLTH0E12144p XP_002554004.1 1079526 R 559295 CDS KLTH0E12166g 255715447 8292173 complement(1081051..1082037) 1 NC_013081.1 some similarities with uniprot|P53324 Saccharomyces cerevisiae YGR263C; KLTH0E12166p 1082037 8292173 KLTH0E12166g Lachancea thermotolerans CBS 6340 KLTH0E12166p XP_002554005.1 1081051 R 559295 CDS KLTH0E12188g 255715449 8292174 1082142..1083152 1 NC_013081.1 similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C Hypothetical ORF; KLTH0E12188p 1083152 8292174 KLTH0E12188g Lachancea thermotolerans CBS 6340 KLTH0E12188p XP_002554006.1 1082142 D 559295 CDS KLTH0E12210g 255715451 8292175 complement(1083242..1084822) 1 NC_013081.1 highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase that is activated by Mg2 and utilizes NADP as the preferred coenzyme; KLTH0E12210p 1084822 8292175 KLTH0E12210g Lachancea thermotolerans CBS 6340 KLTH0E12210p XP_002554007.1 1083242 R 559295 CDS KLTH0E12232g 255715453 8292176 complement(1085579..1088026) 1 NC_013081.1 weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine not related to the COS family of subtelomerically-encoded proteins; KLTH0E12232p 1088026 8292176 KLTH0E12232g Lachancea thermotolerans CBS 6340 KLTH0E12232p XP_002554008.1 1085579 R 559295 CDS KLTH0E12254g 255715455 8292177 complement(1089636..1091066) 1 NC_013081.1 similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Protein of the inner mitochondrial membrane required for import of mitochondrial matrix proteins; KLTH0E12254p 1091066 8292177 KLTH0E12254g Lachancea thermotolerans CBS 6340 KLTH0E12254p XP_002554009.1 1089636 R 559295 CDS KLTH0E12276g 255715457 8292178 1091241..1092218 1 NC_013081.1 weakly similar to uniprot|Q02770 Saccharomyces cerevisiae YPL064C; KLTH0E12276p 1092218 8292178 KLTH0E12276g Lachancea thermotolerans CBS 6340 KLTH0E12276p XP_002554010.1 1091241 D 559295 CDS KLTH0E12298g 255715459 8292179 complement(1092238..1092918) 1 NC_013081.1 similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole; KLTH0E12298p 1092918 8292179 KLTH0E12298g Lachancea thermotolerans CBS 6340 KLTH0E12298p XP_002554011.1 1092238 R 559295 CDS KLTH0E12320g 255715461 8292180 complement(join(1093069..1094286,1094348..1094425)) 1 NC_013081.1 similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Hypothetical ORF; KLTH0E12320p 1094425 8292180 KLTH0E12320g Lachancea thermotolerans CBS 6340 KLTH0E12320p XP_002554012.1 1093069 R 559295 CDS KLTH0E12342g 255715463 8292181 complement(1094784..1097270) 1 NC_013081.1 similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W CDC47 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; KLTH0E12342p 1097270 8292181 KLTH0E12342g Lachancea thermotolerans CBS 6340 KLTH0E12342p XP_002554013.1 1094784 R 559295 CDS KLTH0E12364g 255715465 8292182 1098610..1099164 1 NC_013081.1 weakly similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Hypothetical ORF; KLTH0E12364p 1099164 8292182 KLTH0E12364g Lachancea thermotolerans CBS 6340 KLTH0E12364p XP_002554014.1 1098610 D 559295 CDS KLTH0E12386g 255715467 8292183 1099354..1100172 1 NC_013081.1 conserved hypothetical protein; KLTH0E12386p 1100172 8292183 KLTH0E12386g Lachancea thermotolerans CBS 6340 KLTH0E12386p XP_002554015.1 1099354 D 559295 CDS KLTH0E12408g 255715469 8292184 complement(1100242..1100904) 1 NC_013081.1 similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein required for the protein degradation process associated with the ER involved in the retrograde transport of misfolded or unassembled proteins; KLTH0E12408p 1100904 8292184 KLTH0E12408g Lachancea thermotolerans CBS 6340 KLTH0E12408p XP_002554016.1 1100242 R 559295 CDS KLTH0E12430g 255715471 8292185 1101025..1102005 1 NC_013081.1 similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase increases the intracellular pool of geranylgeranyl diphosphate suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP- binding proteins that mediate vesicular traffic; KLTH0E12430p 1102005 8292185 KLTH0E12430g Lachancea thermotolerans CBS 6340 KLTH0E12430p XP_002554017.1 1101025 D 559295 CDS KLTH0E12452g 255715473 8292186 complement(1102014..1103561) 1 NC_013081.1 similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Protein of unknown function localized to the cytoplasm computational analysis of large- scale protein- protein interaction data suggests a possible role in transcriptional regulation; KLTH0E12452p 1103561 8292186 KLTH0E12452g Lachancea thermotolerans CBS 6340 KLTH0E12452p XP_002554018.1 1102014 R 559295 CDS KLTH0E12474g 255715475 8292187 1103878..1104261 1 NC_013081.1 weakly similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Hypothetical ORF; KLTH0E12474p 1104261 8292187 KLTH0E12474g Lachancea thermotolerans CBS 6340 KLTH0E12474p XP_002554019.1 1103878 D 559295 CDS KLTH0E12496g 255715477 8292188 complement(1104359..1109278) 1 NC_013081.1 conserved hypothetical protein; KLTH0E12496p 1109278 8292188 KLTH0E12496g Lachancea thermotolerans CBS 6340 KLTH0E12496p XP_002554020.1 1104359 R 559295 CDS KLTH0E12518g 255715479 8292189 complement(join(1109548..1111197,1111361..1111369)) 1 NC_013081.1 similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains involved in establishing cell polarity and morphogenesis functions as a scaffold protein for complexes that include Cdc24p Ste5p Ste20p and Rsr1p; KLTH0E12518p 1111369 8292189 KLTH0E12518g Lachancea thermotolerans CBS 6340 KLTH0E12518p XP_002554021.1 1109548 R 559295 CDS KLTH0E12540g 255715481 8292190 complement(1111576..1113834) 1 NC_013081.1 some similarities with uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Putative ubiquitin- specific protease; KLTH0E12540p 1113834 8292190 KLTH0E12540g Lachancea thermotolerans CBS 6340 KLTH0E12540p XP_002554022.1 1111576 R 559295 CDS KLTH0E12562g 255715483 8292191 complement(1114263..1116410) 1 NC_013081.1 similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to the cortex of mother cells but not to daughter cells; KLTH0E12562p 1116410 8292191 KLTH0E12562g Lachancea thermotolerans CBS 6340 KLTH0E12562p XP_002554023.1 1114263 R 559295 CDS KLTH0E12584g 255715485 8292192 complement(1116789..1118801) 1 NC_013081.1 some similarities with uniprot|P07261 Saccharomyces cerevisiae YPL075W GCR1 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr2p; KLTH0E12584p 1118801 8292192 KLTH0E12584g Lachancea thermotolerans CBS 6340 KLTH0E12584p XP_002554024.1 1116789 R 559295 CDS KLTH0E12606g 255715487 8292193 1120419..1122686 1 NC_013081.1 similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification; KLTH0E12606p 1122686 8292193 KLTH0E12606g Lachancea thermotolerans CBS 6340 KLTH0E12606p XP_002554025.1 1120419 D 559295 CDS KLTH0E12628g 255715489 8292194 complement(1122745..1123569) 1 NC_013081.1 similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N- acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-C protein; KLTH0E12628p 1123569 8292194 KLTH0E12628g Lachancea thermotolerans CBS 6340 KLTH0E12628p XP_002554026.1 1122745 R 559295 CDS KLTH0E12650g 255715491 8292195 1123718..1124128 1 NC_013081.1 some similarities with uniprot|Q02831 Saccharomyces cerevisiae YPL077C Hypothetical ORF; KLTH0E12650p 1124128 8292195 KLTH0E12650g Lachancea thermotolerans CBS 6340 KLTH0E12650p XP_002554027.1 1123718 D 559295 CDS KLTH0E12672g 255715493 8292196 1125095..1126759 1 NC_013081.1 highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase catalyzes the interconversion of glucose-6- phosphate and fructose-6-phosphate required for cell cycle progression and completion of the gluconeogenic events of sporulation; KLTH0E12672p 1126759 8292196 KLTH0E12672g Lachancea thermotolerans CBS 6340 KLTH0E12672p XP_002554028.1 1125095 D 559295 CDS KLTH0E12694g 255715495 8292197 1126940..1128196 1 NC_013081.1 similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF- I) regulates the RAS/cAMP pathway via sequestration of Npr1p kinase localizes to the nucleus and cytoplasm homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; KLTH0E12694p 1128196 8292197 KLTH0E12694g Lachancea thermotolerans CBS 6340 KLTH0E12694p XP_002554029.1 1126940 D 559295 CDS KLTH0E12716g 255715497 8292198 join(1128393..1128463,1128744..1129383) 1 NC_013081.1 similar to uniprot|P05626 Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0E12716p 1129383 8292198 KLTH0E12716g Lachancea thermotolerans CBS 6340 KLTH0E12716p XP_002554030.1 1128393 D 559295 CDS KLTH0E12738g 255715499 8292199 complement(1129641..1129907) 1 NC_013081.1 some similarities with uniprot|P38305 Saccharomyces cerevisiae YBR194W SOY1 Synthetic with Old Yellow Enzyme; KLTH0E12738p 1129907 8292199 KLTH0E12738g Lachancea thermotolerans CBS 6340 KLTH0E12738p XP_002554031.1 1129641 R 559295 CDS KLTH0E12760g 255715501 8292200 1130137..1130793 1 NC_013081.1 similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; KLTH0E12760p 1130793 8292200 KLTH0E12760g Lachancea thermotolerans CBS 6340 KLTH0E12760p XP_002554032.1 1130137 D 559295 CDS KLTH0E12782g 255715503 8292201 complement(1130877..1131995) 1 NC_013081.1 similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration Probable carrier protein mitochondrial; KLTH0E12782p 1131995 8292201 KLTH0E12782g Lachancea thermotolerans CBS 6340 KLTH0E12782p XP_002554033.1 1130877 R 559295 CDS KLTH0E12804g 255715505 8292202 complement(1132448..1132891) 1 NC_013081.1 highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W; KLTH0E12804p 1132891 8292202 KLTH0E12804g Lachancea thermotolerans CBS 6340 KLTH0E12804p XP_002554034.1 1132448 R 559295 CDS KLTH0E12826g 255715507 8292203 complement(join(1134231..1134805,1135209..1135215)) 1 NC_013081.1 highly similar to uniprot|O13516 Saccharomyces cerevisiae YPL081W RPS9A and to uniprot|P05755 Saccharomyces cerevisiae YBR189W RPS9B Proteins component of the small (40S) ribosomal subunit; KLTH0E12826p 1135215 8292203 KLTH0E12826g Lachancea thermotolerans CBS 6340 KLTH0E12826p XP_002554035.1 1134231 R 559295 CDS KLTH0E12848g 255715509 8292204 complement(1135587..1136771) 1 NC_013081.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase; KLTH0E12848p 1136771 8292204 KLTH0E12848g Lachancea thermotolerans CBS 6340 KLTH0E12848p XP_002554036.1 1135587 R 559295 CDS KLTH0E12870g 255715511 8292205 1137596..1143238 1 NC_013081.1 highly similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription removes Spt15p (TBP) from DNA via its C-terminal ATPase activity forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; KLTH0E12870p 1143238 8292205 KLTH0E12870g Lachancea thermotolerans CBS 6340 KLTH0E12870p XP_002554037.1 1137596 D 559295 CDS KLTH0E12892g 255715513 8292206 1143426..1143854 1 NC_013081.1 weakly similar to uniprot|P38302 Saccharomyces cerevisiae YBR188C NTC20 Member of a complex, including Prp19p, that binds to the spliceosome; KLTH0E12892p 1143854 8292206 KLTH0E12892g Lachancea thermotolerans CBS 6340 KLTH0E12892p XP_002554038.1 1143426 D 559295 CDS KLTH0E12914g 255715515 8292207 complement(1143926..1144768) 1 NC_013081.1 similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W Hypothetical ORF; KLTH0E12914p 1144768 8292207 KLTH0E12914g Lachancea thermotolerans CBS 6340 KLTH0E12914p XP_002554039.1 1143926 R 559295 CDS KLTH0E12936g 255715517 8292208 complement(1145066..1146700) 1 NC_013081.1 similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint which prevents chromosome segregation when recombination and chromosome synapsis are defective also represses meiotic interhomolog recombination in the rDNA; KLTH0E12936p 1146700 8292208 KLTH0E12936g Lachancea thermotolerans CBS 6340 KLTH0E12936p XP_002554040.1 1145066 R 559295 CDS KLTH0E12980g 255715519 8292210 1148335..1149666 1 NC_013081.1 similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p; KLTH0E12980p 1149666 8292210 KLTH0E12980g Lachancea thermotolerans CBS 6340 KLTH0E12980p XP_002554041.1 1148335 D 559295 CDS KLTH0E13002g 255715521 8292211 complement(1149687..1152158) 1 NC_013081.1 similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; KLTH0E13002p 1152158 8292211 KLTH0E13002g Lachancea thermotolerans CBS 6340 KLTH0E13002p XP_002554042.1 1149687 R 559295 CDS KLTH0E13024g 255715523 8292212 1152383..1153207 1 NC_013081.1 similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane; KLTH0E13024p 1153207 8292212 KLTH0E13024g Lachancea thermotolerans CBS 6340 KLTH0E13024p XP_002554043.1 1152383 D 559295 CDS KLTH0E13046g 255715525 8292213 complement(1153353..1160468) 1 NC_013081.1 some similarities with uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes interacts with Sec23p Sec24p and Sec31p; KLTH0E13046p 1160468 8292213 KLTH0E13046g Lachancea thermotolerans CBS 6340 KLTH0E13046p XP_002554044.1 1153353 R 559295 CDS KLTH0E13068g 255715527 8292214 1160992..1162659 1 NC_013081.1 highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Histone acetyltransferase subunit of the Elongator complex which is a component of the RNA polymerase II holoenzyme activity is directed specifically towards histones H3 and H4 disruption confers resistance to K. lactis zymotoxin; KLTH0E13068p 1162659 8292214 KLTH0E13068g Lachancea thermotolerans CBS 6340 KLTH0E13068p XP_002554045.1 1160992 D 559295 CDS KLTH0E13090g 255715529 8292215 complement(1162705..1163859) 1 NC_013081.1 similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis; KLTH0E13090p 1163859 8292215 KLTH0E13090g Lachancea thermotolerans CBS 6340 KLTH0E13090p XP_002554046.1 1162705 R 559295 CDS KLTH0E13112g 255715531 8292216 complement(1164233..1165240) 1 NC_013081.1 similar to uniprot|P38298 Saccharomyces cerevisiae YBR183W YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity catalyzes both breakdown and synthesis of phytoceramide overexpression confers fumonisin B1 resistance; KLTH0E13112p 1165240 8292216 KLTH0E13112g Lachancea thermotolerans CBS 6340 KLTH0E13112p XP_002554047.1 1164233 R 559295 CDS KLTH0E13134g 255715533 8292217 complement(1165757..1166602) 1 NC_013081.1 conserved hypothetical protein; KLTH0E13134p 1166602 8292217 KLTH0E13134g Lachancea thermotolerans CBS 6340 KLTH0E13134p XP_002554048.1 1165757 R 559295 CDS KLTH0E13156g 255715535 8292218 join(1167513..1167568,1167713..1169546) 1 NC_013081.1 some similarities with uniprot|Q12224 Saccharomyces cerevisiae YPL089C RLM1 MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; KLTH0E13156p 1169546 8292218 KLTH0E13156g Lachancea thermotolerans CBS 6340 KLTH0E13156p XP_002554049.1 1167513 D 559295 CDS KLTH0E13178g 255715537 8292219 join(1170831..1170836,1171067..1171771) 1 NC_013081.1 highly similar to uniprot|P02365 Saccharomyces cerevisiae YPL090C RPS6A and to uniprot|P02365 Saccharomyces cerevisiae YBR181C RPS6B Proteins component of the small (40S) ribosomal subunit; KLTH0E13178p 1171771 8292219 KLTH0E13178g Lachancea thermotolerans CBS 6340 KLTH0E13178p XP_002554050.1 1170831 D 559295 CDS KLTH0E13200g 255715539 8292220 complement(1171972..1173420) 1 NC_013081.1 highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase converts oxidized glutathione to reduced glutathione; KLTH0E13200p 1173420 8292220 KLTH0E13200g Lachancea thermotolerans CBS 6340 KLTH0E13200p XP_002554051.1 1171972 R 559295 CDS KLTH0E13222g 255715541 8292221 complement(1175450..1177150) 1 NC_013081.1 similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily essential for spore wall synthesis facilitates the translocation of bisformyl dityrosine through the prospore membrane; KLTH0E13222p 1177150 8292221 KLTH0E13222g Lachancea thermotolerans CBS 6340 KLTH0E13222p XP_002554052.1 1175450 R 559295 CDS KLTH0E13244g 255715543 8292222 complement(1177498..1179441) 1 NC_013081.1 highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis member of the ODN family of nucleolar G-proteins; KLTH0E13244p 1179441 8292222 KLTH0E13244g Lachancea thermotolerans CBS 6340 KLTH0E13244p XP_002554053.1 1177498 R 559295 CDS KLTH0E13266g 255715545 8292223 1180881..1181612 1 NC_013081.1 similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C; KLTH0E13266p 1181612 8292223 KLTH0E13266g Lachancea thermotolerans CBS 6340 KLTH0E13266p XP_002554054.1 1180881 D 559295 CDS KLTH0E13288g 255715547 8292224 1183241..1185778 1 NC_013081.1 similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome contains N-terminal GTPase domain; KLTH0E13288p 1185778 8292224 KLTH0E13288g Lachancea thermotolerans CBS 6340 KLTH0E13288p XP_002554055.1 1183241 D 559295 CDS KLTH0E13310g 255715549 8292225 1186305..1187639 1 NC_013081.1 similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase may be involved in lipid metabolism null mutant slightly temperature sensitive at 37C and similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YMR210c uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF; KLTH0E13310p 1187639 8292225 KLTH0E13310g Lachancea thermotolerans CBS 6340 KLTH0E13310p XP_002554056.1 1186305 D 559295 CDS KLTH0E13332g 255715551 8292226 complement(1187670..1188791) 1 NC_013081.1 similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 de-N-glycosylation enzyme peptide:N- glycanase; KLTH0E13332p 1188791 8292226 KLTH0E13332g Lachancea thermotolerans CBS 6340 KLTH0E13332p XP_002554057.1 1187670 R 559295 CDS KLTH0E13354g 255715553 8292227 complement(1189037..1190428) 1 NC_013081.1 similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W; KLTH0E13354p 1190428 8292227 KLTH0E13354g Lachancea thermotolerans CBS 6340 KLTH0E13354p XP_002554058.1 1189037 R 559295 CDS KLTH0E13376g 255715555 8292228 1190563..1190946 1 NC_013081.1 highly similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C Hypothetical ORF; KLTH0E13376p 1190946 8292228 KLTH0E13376g Lachancea thermotolerans CBS 6340 KLTH0E13376p XP_002554059.1 1190563 D 559295 CDS KLTH0E13398g 255715557 8292229 1191052..1191537 1 NC_013081.1 weakly similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C FMP14 The authentic non-tagged protein was localized to the mitochondria; KLTH0E13398p 1191537 8292229 KLTH0E13398g Lachancea thermotolerans CBS 6340 KLTH0E13398p XP_002554060.1 1191052 D 559295 CDS KLTH0E13420g 255715559 8292230 complement(1191554..1192744) 1 NC_013081.1 similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphatidylinositol 3 5- bisphosphate- binding protein required for maturation of pro- aminopeptidase I predicted to fold as a seven-bladed beta- propeller displays punctate cytoplasmic localization; KLTH0E13420p 1192744 8292230 KLTH0E13420g Lachancea thermotolerans CBS 6340 KLTH0E13420p XP_002554061.1 1191554 R 559295 CDS KLTH0E13442g 255715561 8292231 complement(1192885..1194228) 1 NC_013081.1 similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity; KLTH0E13442p 1194228 8292231 KLTH0E13442g Lachancea thermotolerans CBS 6340 KLTH0E13442p XP_002554062.1 1192885 R 559295 CDS KLTH0E13464g 255715563 8292232 1194688..1196061 1 NC_013081.1 similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C; KLTH0E13464p 1196061 8292232 KLTH0E13464g Lachancea thermotolerans CBS 6340 KLTH0E13464p XP_002554063.1 1194688 D 559295 CDS KLTH0E13486g 255715565 8292233 complement(1196098..1197036) 1 NC_013081.1 similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase required for pantothenic acid biosynthesis converts 2- oxoisovalerate into 2- dehydropantoate; KLTH0E13486p 1197036 8292233 KLTH0E13486g Lachancea thermotolerans CBS 6340 KLTH0E13486p XP_002554064.1 1196098 R 559295 CDS KLTH0E13508g 255715567 8292234 1197940..1199244 1 NC_013081.1 weakly similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; KLTH0E13508p 1199244 8292234 KLTH0E13508g Lachancea thermotolerans CBS 6340 KLTH0E13508p XP_002554065.1 1197940 D 559295 CDS KLTH0E13530g 255715569 8292235 complement(1200329..1202350) 1 NC_013081.1 similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene; KLTH0E13530p 1202350 8292235 KLTH0E13530g Lachancea thermotolerans CBS 6340 KLTH0E13530p XP_002554066.1 1200329 R 559295 CDS KLTH0E13552g 255715571 8292236 complement(1202406..1203356) 1 NC_013081.1 similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; KLTH0E13552p 1203356 8292236 KLTH0E13552g Lachancea thermotolerans CBS 6340 KLTH0E13552p XP_002554067.1 1202406 R 559295 CDS KLTH0E13574g 255715573 8292237 1203813..1204316 1 NC_013081.1 similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome degraded by proteasome upon completion of its assembly involved in ubiquitin- mediated proteolysis mutant defective in degradation of short-lived proteins; KLTH0E13574p 1204316 8292237 KLTH0E13574g Lachancea thermotolerans CBS 6340 KLTH0E13574p XP_002554068.1 1203813 D 559295 CDS KLTH0E13596g 255715575 8292238 1204633..1206933 1 NC_013081.1 weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C SMY2 partial suppressor of myo2-66 Kinesin-related protein suppressing myosin defects (MYO2) and to uniprot|Q02875 YPL105c; KLTH0E13596p 1206933 8292238 KLTH0E13596g Lachancea thermotolerans CBS 6340 KLTH0E13596p XP_002554069.1 1204633 D 559295 CDS KLTH0E13618g 255715577 8292239 complement(1207060..1207677) 1 NC_013081.1 similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER; KLTH0E13618p 1207677 8292239 KLTH0E13618g Lachancea thermotolerans CBS 6340 KLTH0E13618p XP_002554070.1 1207060 R 559295 CDS KLTH0E13640g 255715579 8292240 1207827..1209572 1 NC_013081.1 similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Endoplasmic reticulum and nuclear membrane protein forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation; KLTH0E13640p 1209572 8292240 KLTH0E13640g Lachancea thermotolerans CBS 6340 KLTH0E13640p XP_002554071.1 1207827 D 559295 CDS KLTH0E13662g 255715581 8292241 1209958..1212042 1 NC_013081.1 highly similar to uniprot|P32589 Saccharomyces cerevisiae YPL106C SSE1 HSP70 family member highly homologous to Ssa1p and Sse2p; KLTH0E13662p 1212042 8292241 KLTH0E13662g Lachancea thermotolerans CBS 6340 KLTH0E13662p XP_002554072.1 1209958 D 559295 CDS KLTH0E13684g 255715583 8292242 complement(1212457..1213134) 1 NC_013081.1 similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Hypothetical ORF; KLTH0E13684p 1213134 8292242 KLTH0E13684g Lachancea thermotolerans CBS 6340 KLTH0E13684p XP_002554073.1 1212457 R 559295 CDS KLTH0E13706g 255715585 8292243 complement(1213291..1214445) 1 NC_013081.1 weakly similar to uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein involved in negative regulation of peroxisome size partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; KLTH0E13706p 1214445 8292243 KLTH0E13706g Lachancea thermotolerans CBS 6340 KLTH0E13706p XP_002554074.1 1213291 R 559295 CDS KLTH0E13728g 255715587 8292244 1214641..1215045 1 NC_013081.1 similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; KLTH0E13728p 1215045 8292244 KLTH0E13728g Lachancea thermotolerans CBS 6340 KLTH0E13728p XP_002554075.1 1214641 D 559295 CDS KLTH0E13750g 255715589 8292245 complement(1215140..1215682) 1 NC_013081.1 similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Hypothetical ORF; KLTH0E13750p 1215682 8292245 KLTH0E13750g Lachancea thermotolerans CBS 6340 KLTH0E13750p XP_002554076.1 1215140 R 559295 CDS KLTH0E13772g 255715591 8292246 complement(1215969..1216592) 1 NC_013081.1 similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation expression sensitive to nitrogen catabolite repression; KLTH0E13772p 1216592 8292246 KLTH0E13772g Lachancea thermotolerans CBS 6340 KLTH0E13772p XP_002554077.1 1215969 R 559295 CDS KLTH0E13794g 255715593 8292247 1216955..1218409 1 NC_013081.1 similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Step of tyrosine biosynthesis pathway Prephenate dehydrogenase (NADP ); KLTH0E13794p 1218409 8292247 KLTH0E13794g Lachancea thermotolerans CBS 6340 KLTH0E13794p XP_002554078.1 1216955 D 559295 CDS KLTH0E13816g 255715595 8292248 complement(1218576..1219307) 1 NC_013081.1 weakly similar to uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity; KLTH0E13816p 1219307 8292248 KLTH0E13816g Lachancea thermotolerans CBS 6340 KLTH0E13816p XP_002554079.1 1218576 R 559295 CDS KLTH0E13838g 255715597 8292249 1219497..1220048 1 NC_013081.1 highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic;regulates potassium influx; G protein of the Rassuperfamily, similar to ADP- ribosylation factor; KLTH0E13838p 1220048 8292249 KLTH0E13838g Lachancea thermotolerans CBS 6340 KLTH0E13838p XP_002554080.1 1219497 D 559295 CDS KLTH0E13860g 255715599 8292250 join(1220152..1222205,1222274..1222409,1222519..1222545) 1 NC_013081.1 similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Hypothetical ORF; KLTH0E13860p 1222545 8292250 KLTH0E13860g Lachancea thermotolerans CBS 6340 KLTH0E13860p XP_002554081.1 1220152 D 559295 CDS KLTH0E13882g 255715601 8292251 1222695..1226552 1 NC_013081.1 similar to Saccharomyces cerevisiae uniprot|Q02979 YPL110C GDE1 Glycerophosphocholine (GroPCho) phosphodiesterase; KLTH0E13882p 1226552 8292251 KLTH0E13882g Lachancea thermotolerans CBS 6340 KLTH0E13882p XP_002554082.1 1222695 D 559295 CDS KLTH0E13904g 255715603 8292252 complement(1226678..1227055) 1 NC_013081.1 conserved hypothetical protein; KLTH0E13904p 1227055 8292252 KLTH0E13904g Lachancea thermotolerans CBS 6340 KLTH0E13904p XP_002554083.1 1226678 R 559295 CDS KLTH0E13926g 255715605 8292253 1228505..1230595 1 NC_013081.1 similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0E13926p 1230595 8292253 KLTH0E13926g Lachancea thermotolerans CBS 6340 KLTH0E13926p XP_002554084.1 1228505 D 559295 CDS KLTH0E13948g 255715607 8292254 complement(1231122..1232438) 1 NC_013081.1 similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W Hypothetical ORF; KLTH0E13948p 1232438 8292254 KLTH0E13948g Lachancea thermotolerans CBS 6340 KLTH0E13948p XP_002554085.1 1231122 R 559295 CDS KLTH0E13970g 255715609 8292255 1233034..1233915 1 NC_013081.1 conserved hypothetical protein; KLTH0E13970p 1233915 8292255 KLTH0E13970g Lachancea thermotolerans CBS 6340 KLTH0E13970p XP_002554086.1 1233034 D 559295 CDS KLTH0E13992g 255715611 8292256 1234550..1239202 1 NC_013081.1 similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF; KLTH0E13992p 1239202 8292256 KLTH0E13992g Lachancea thermotolerans CBS 6340 KLTH0E13992p XP_002554087.1 1234550 D 559295 CDS KLTH0E14014g 255715613 8292257 1239444..1240904 1 NC_013081.1 similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus; KLTH0E14014p 1240904 8292257 KLTH0E14014g Lachancea thermotolerans CBS 6340 KLTH0E14014p XP_002554088.1 1239444 D 559295 CDS KLTH0E14036g 255715615 8292258 complement(1240971..1241600) 1 NC_013081.1 similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W; KLTH0E14036p 1241600 8292258 KLTH0E14036g Lachancea thermotolerans CBS 6340 KLTH0E14036p XP_002554089.1 1240971 R 559295 CDS KLTH0E14058g 255715617 8292259 1243429..1244628 1 NC_013081.1 similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase; KLTH0E14058p 1244628 8292259 KLTH0E14058g Lachancea thermotolerans CBS 6340 KLTH0E14058p XP_002554090.1 1243429 D 559295 CDS KLTH0E14080g 255715619 8292260 1244955..1246658 1 NC_013081.1 similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress; KLTH0E14080p 1246658 8292260 KLTH0E14080g Lachancea thermotolerans CBS 6340 KLTH0E14080p XP_002554091.1 1244955 D 559295 CDS KLTH0E14102g 255715621 8292261 1247865..1248032 1 NC_013081.1 similar to uniprot|Q05827 Saccharomyces cerevisiae YMR251W-A HOR7; KLTH0E14102p 1248032 8292261 KLTH0E14102g Lachancea thermotolerans CBS 6340 KLTH0E14102p XP_002554092.1 1247865 D 559295 CDS KLTH0E14124g 255715623 8292262 join(1249365..1249425,1249605..1250812) 1 NC_013081.1 similar to uniprot|P38248 Saccharomyces cerevisiae YBR078w and to uniprot|Q12355 Saccharomyces cerevisiae YDR055w; KLTH0E14124p 1250812 8292262 KLTH0E14124g Lachancea thermotolerans CBS 6340 KLTH0E14124p XP_002554093.1 1249365 D 559295 CDS KLTH0E14146g 255715625 8292263 complement(1251360..1251950) 1 NC_013081.1 conserved hypothetical protein; KLTH0E14146p 1251950 8292263 KLTH0E14146g Lachancea thermotolerans CBS 6340 KLTH0E14146p XP_002554094.1 1251360 R 559295 CDS KLTH0E14168g 255715627 8292264 complement(1252182..1255100) 1 NC_013081.1 similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; KLTH0E14168p 1255100 8292264 KLTH0E14168g Lachancea thermotolerans CBS 6340 KLTH0E14168p XP_002554095.1 1252182 R 559295 CDS KLTH0E14190g 255715629 8292265 complement(1255261..1257552) 1 NC_013081.1 highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF; KLTH0E14190p 1257552 8292265 KLTH0E14190g Lachancea thermotolerans CBS 6340 KLTH0E14190p XP_002554096.1 1255261 R 559295 CDS KLTH0E14212g 255715631 8292266 complement(join(1257857..1258186,1258253..1258492)) 1 NC_013081.1 some similarities with uniprot|Q12025 Saccharomyces cerevisiae YDR056C Hypothetical ORF; KLTH0E14212p 1258492 8292266 KLTH0E14212g Lachancea thermotolerans CBS 6340 KLTH0E14212p XP_002554097.1 1257857 R 559295 CDS KLTH0E14234g 255715633 8292267 1258702..1260264 1 NC_013081.1 some similarities with uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 Glycoprotein of the ER membrane involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins; KLTH0E14234p 1260264 8292267 KLTH0E14234g Lachancea thermotolerans CBS 6340 KLTH0E14234p XP_002554098.1 1258702 D 559295 CDS KLTH0E14256g 255715635 8292268 complement(1260356..1264357) 1 NC_013081.1 similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex involved in proper assembly of the complex also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex; KLTH0E14256p 1264357 8292268 KLTH0E14256g Lachancea thermotolerans CBS 6340 KLTH0E14256p XP_002554099.1 1260356 R 559295 CDS KLTH0E14300g 255715637 8292270 complement(join(1265287..1265686,1265893..1265936)) 1 NC_013081.1 highly similar to uniprot|P15731 Saccharomyces cerevisiae YBR082C UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins interacts with E3-CaM in ubiquitinating calmodulin interacts with many SCF ubiquitin protein ligases component of the cellular stress response; KLTH0E14300p 1265936 8292270 KLTH0E14300g Lachancea thermotolerans CBS 6340 KLTH0E14300p XP_002554100.1 1265287 R 559295 CDS KLTH0E14322g 255715639 8292271 1267079..1270381 1 NC_013081.1 similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Protein required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre- ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein; KLTH0E14322p 1270381 8292271 KLTH0E14322g Lachancea thermotolerans CBS 6340 KLTH0E14322p XP_002554101.1 1267079 D 559295 CDS KLTH0E14344g 255715641 8292272 1270964..1272574 1 NC_013081.1 some similarities with uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 transcription factor of the TEA/ATTS DNA-binding domain family regulator of Ty1 expression; KLTH0E14344p 1272574 8292272 KLTH0E14344g Lachancea thermotolerans CBS 6340 KLTH0E14344p XP_002554102.1 1270964 D 559295 CDS KLTH0E14366g 255715643 8292273 1272926..1275838 1 NC_013081.1 highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase involved in interconversion between different oxidation states of tetrahydrofolate (THF) provides activities of formyl-THF synthetase methenyl-THF cyclohydrolase and methylene-THF dehydrogenase; KLTH0E14366p 1275838 8292273 KLTH0E14366g Lachancea thermotolerans CBS 6340 KLTH0E14366p XP_002554103.1 1272926 D 559295 CDS KLTH0E14388g 255715645 8292274 complement(join(1277045..1277612,1277906..1277907)) 1 NC_013081.1 highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A RPL19A and to uniprot|P05735 Saccharomyces cerevisiae YBL027W RPL19B Proteins component of the large (60S) ribosomal subunit; KLTH0E14388p 1277907 8292274 KLTH0E14388g Lachancea thermotolerans CBS 6340 KLTH0E14388p XP_002554104.1 1277045 R 559295 CDS KLTH0E14410g 255715647 8292275 1278479..1278805 1 NC_013081.1 similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C Hypothetical ORF; KLTH0E14410p 1278805 8292275 KLTH0E14410g Lachancea thermotolerans CBS 6340 KLTH0E14410p XP_002554105.1 1278479 D 559295 CDS KLTH0E14432g 255715649 8292276 complement(1279338..1280684) 1 NC_013081.1 some similarities with uniprot|P38201 Saccharomyces cerevisiae YBL029W Hypothetical ORF; KLTH0E14432p 1280684 8292276 KLTH0E14432g Lachancea thermotolerans CBS 6340 KLTH0E14432p XP_002554106.1 1279338 R 559295 CDS KLTH0E14454g 255715651 8292277 complement(1282704..1285412) 1 NC_013081.1 some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1(Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; KLTH0E14454p 1285412 8292277 KLTH0E14454g Lachancea thermotolerans CBS 6340 KLTH0E14454p XP_002554107.1 1282704 R 559295 CDS KLTH0E14476g 255715653 8292278 1287603..1288517 1 NC_013081.1 highly similar to uniprot|P18239 Saccharomyces cerevisiae YBL030C PET9 Major ADP/ATP carrier of the mitochondrial inner membrane exchanges cytosolic ADP for mitochondrially synthesized ATP Pet9p and Sal1p have an overlapping function critical for viability; KLTH0E14476p 1288517 8292278 KLTH0E14476g Lachancea thermotolerans CBS 6340 KLTH0E14476p XP_002554108.1 1287603 D 559295 CDS KLTH0E14498g 255715655 8292279 complement(1288808..1289902) 1 NC_013081.1 weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1; KLTH0E14498p 1289902 8292279 KLTH0E14498g Lachancea thermotolerans CBS 6340 KLTH0E14498p XP_002554109.1 1288808 R 559295 CDS KLTH0E14520g 255715657 8292280 complement(1290047..1290904) 1 NC_013081.1 similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W; KLTH0E14520p 1290904 8292280 KLTH0E14520g Lachancea thermotolerans CBS 6340 KLTH0E14520p XP_002554110.1 1290047 R 559295 CDS KLTH0E14542g 255715659 8292281 1291462..1292382 1 NC_013081.1 similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway; KLTH0E14542p 1292382 8292281 KLTH0E14542g Lachancea thermotolerans CBS 6340 KLTH0E14542p XP_002554111.1 1291462 D 559295 CDS KLTH0E14564g 255715661 8292282 complement(1292765..1293049) 1 NC_013081.1 similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A Hypothetical ORF; KLTH0E14564p 1293049 8292282 KLTH0E14564g Lachancea thermotolerans CBS 6340 KLTH0E14564p XP_002554112.1 1292765 R 559295 CDS KLTH0E14586g 255715663 8292283 1293773..1297870 1 NC_013081.1 weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles; KLTH0E14586p 1297870 8292283 KLTH0E14586g Lachancea thermotolerans CBS 6340 KLTH0E14586p XP_002554113.1 1293773 D 559295 CDS KLTH0E14608g 255715665 8292284 1298047..1300008 1 NC_013081.1 similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; KLTH0E14608p 1300008 8292284 KLTH0E14608g Lachancea thermotolerans CBS 6340 KLTH0E14608p XP_002554114.1 1298047 D 559295 CDS KLTH0E14630g 255715667 8292285 complement(1300223..1302895) 1 NC_013081.1 highly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2; KLTH0E14630p 1302895 8292285 KLTH0E14630g Lachancea thermotolerans CBS 6340 KLTH0E14630p XP_002554115.1 1300223 R 559295 CDS KLTH0E14652g 255715669 8292286 1303126..1303893 1 NC_013081.1 similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non-specific due to the lack of the second domain which presumably determines specificity; KLTH0E14652p 1303893 8292286 KLTH0E14652g Lachancea thermotolerans CBS 6340 KLTH0E14652p XP_002554116.1 1303126 D 559295 CDS KLTH0E14674g 255715671 8292287 complement(1304048..1306918) 1 NC_013081.1 similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex; KLTH0E14674p 1306918 8292287 KLTH0E14674g Lachancea thermotolerans CBS 6340 KLTH0E14674p XP_002554117.1 1304048 R 559295 CDS KLTH0E14696g 255715673 8292288 1307028..1308182 1 NC_013081.1 highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; KLTH0E14696p 1308182 8292288 KLTH0E14696g Lachancea thermotolerans CBS 6340 KLTH0E14696p XP_002554118.1 1307028 D 559295 CDS KLTH0E14718g 255715675 8292289 complement(1308255..1308908) 1 NC_013081.1 similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit; KLTH0E14718p 1308908 8292289 KLTH0E14718g Lachancea thermotolerans CBS 6340 KLTH0E14718p XP_002554119.1 1308255 R 559295 CDS KLTH0E14740g 255715677 8292290 1309385..1310800 1 NC_013081.1 similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W; KLTH0E14740p 1310800 8292290 KLTH0E14740g Lachancea thermotolerans CBS 6340 KLTH0E14740p XP_002554120.1 1309385 D 559295 CDS KLTH0E14762g 255715679 8292291 1311106..1312950 1 NC_013081.1 similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta; KLTH0E14762p 1312950 8292291 KLTH0E14762g Lachancea thermotolerans CBS 6340 KLTH0E14762p XP_002554121.1 1311106 D 559295 CDS KLTH0E14784g 255715681 8292292 complement(1313245..1316493) 1 NC_013081.1 similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy); KLTH0E14784p 1316493 8292292 KLTH0E14784g Lachancea thermotolerans CBS 6340 KLTH0E14784p XP_002554122.1 1313245 R 559295 CDS KLTH0E14806g 255715683 8292293 1316897..1317421 1 NC_013081.1 similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus; KLTH0E14806p 1317421 8292293 KLTH0E14806g Lachancea thermotolerans CBS 6340 KLTH0E14806p XP_002554123.1 1316897 D 559295 CDS KLTH0E14828g 255715685 8292294 complement(1317551..1318327) 1 NC_013081.1 highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; KLTH0E14828p 1318327 8292294 KLTH0E14828g Lachancea thermotolerans CBS 6340 KLTH0E14828p XP_002554124.1 1317551 R 559295 CDS KLTH0E14850g 255715687 8292295 complement(1318736..1319017) 1 NC_013081.1 highly similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters; KLTH0E14850p 1319017 8292295 KLTH0E14850g Lachancea thermotolerans CBS 6340 KLTH0E14850p XP_002554125.1 1318736 R 559295 CDS KLTH0E14872g 255715689 8292296 complement(1320179..1320478) 1 NC_013081.1 similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins; KLTH0E14872p 1320478 8292296 KLTH0E14872g Lachancea thermotolerans CBS 6340 KLTH0E14872p XP_002554126.1 1320179 R 559295 CDS KLTH0E14894g 255715691 8292297 join(1320663..1320674,1320886..1323090) 1 NC_013081.1 similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W Hypothetical ORF; KLTH0E14894p 1323090 8292297 KLTH0E14894g Lachancea thermotolerans CBS 6340 KLTH0E14894p XP_002554127.1 1320663 D 559295 CDS KLTH0E14916g 255715693 8292298 complement(1323143..1324165) 1 NC_013081.1 weakly similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 Hypothetical ORF; KLTH0E14916p 1324165 8292298 KLTH0E14916g Lachancea thermotolerans CBS 6340 KLTH0E14916p XP_002554128.1 1323143 R 559295 CDS KLTH0E14938g 255715695 8292299 1324507..1325799 1 NC_013081.1 conserved hypothetical protein; KLTH0E14938p 1325799 8292299 KLTH0E14938g Lachancea thermotolerans CBS 6340 KLTH0E14938p XP_002554129.1 1324507 D 559295 CDS KLTH0E14982g 255715697 8292301 1327925..1328608 1 NC_013081.1 similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W Hypothetical ORF; KLTH0E14982p 1328608 8292301 KLTH0E14982g Lachancea thermotolerans CBS 6340 KLTH0E14982p XP_002554130.1 1327925 D 559295 CDS KLTH0E15004g 255715699 8292302 1328930..1330165 1 NC_013081.1 similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene; KLTH0E15004p 1330165 8292302 KLTH0E15004g Lachancea thermotolerans CBS 6340 KLTH0E15004p XP_002554131.1 1328930 D 559295 CDS KLTH0E15026g 255715701 8292303 1331171..1335730 1 NC_013081.1 similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting; KLTH0E15026p 1335730 8292303 KLTH0E15026g Lachancea thermotolerans CBS 6340 KLTH0E15026p XP_002554132.1 1331171 D 559295 CDS KLTH0E15048g 255715703 8292304 1335840..1338881 1 NC_013081.1 similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; KLTH0E15048p 1338881 8292304 KLTH0E15048g Lachancea thermotolerans CBS 6340 KLTH0E15048p XP_002554133.1 1335840 D 559295 CDS KLTH0E15070g 255715705 8292305 1338973..1340985 1 NC_013081.1 similar to uniprot|P38259 Saccharomyces cerevisiae YBR100W; KLTH0E15070p 1340985 8292305 KLTH0E15070g Lachancea thermotolerans CBS 6340 KLTH0E15070p XP_002554134.1 1338973 D 559295 CDS KLTH0E15092g 255715707 8292306 complement(1341132..1341998) 1 NC_013081.1 similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor cytosolic homolog of Sls1p which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; KLTH0E15092p 1341998 8292306 KLTH0E15092g Lachancea thermotolerans CBS 6340 KLTH0E15092p XP_002554135.1 1341132 R 559295 CDS KLTH0E15114g 255715709 8292307 1342239..1344314 1 NC_013081.1 conserved hypothetical protein; KLTH0E15114p 1344314 8292307 KLTH0E15114g Lachancea thermotolerans CBS 6340 KLTH0E15114p XP_002554136.1 1342239 D 559295 CDS KLTH0E15136g 255715711 8292308 complement(1344346..1346430) 1 NC_013081.1 similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis; KLTH0E15136p 1346430 8292308 KLTH0E15136g Lachancea thermotolerans CBS 6340 KLTH0E15136p XP_002554137.1 1344346 R 559295 CDS KLTH0E15158g 255715713 8292309 1346780..1348309 1 NC_013081.1 similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 Sir4p-Interacting Factor 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal; KLTH0E15158p 1348309 8292309 KLTH0E15158g Lachancea thermotolerans CBS 6340 KLTH0E15158p XP_002554138.1 1346780 D 559295 CDS KLTH0E15180g 255715715 8292310 1348583..1349596 1 NC_013081.1 similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W; KLTH0E15180p 1349596 8292310 KLTH0E15180g Lachancea thermotolerans CBS 6340 KLTH0E15180p XP_002554139.1 1348583 D 559295 CDS KLTH0E15202g 255715717 8292311 1350050..1351102 1 NC_013081.1 similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; KLTH0E15202p 1351102 8292311 KLTH0E15202g Lachancea thermotolerans CBS 6340 KLTH0E15202p XP_002554140.1 1350050 D 559295 CDS KLTH0E15224g 255715719 8292312 1351301..1352212 1 NC_013081.1 highly similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family; KLTH0E15224p 1352212 8292312 KLTH0E15224g Lachancea thermotolerans CBS 6340 KLTH0E15224p XP_002554141.1 1351301 D 559295 CDS KLTH0E15246g 255715721 8292313 complement(1352316..1353089) 1 NC_013081.1 highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis; KLTH0E15246p 1353089 8292313 KLTH0E15246g Lachancea thermotolerans CBS 6340 KLTH0E15246p XP_002554142.1 1352316 R 559295 CDS KLTH0E15268g 255715723 8292314 complement(1353439..1354302) 1 NC_013081.1 similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C; KLTH0E15268p 1354302 8292314 KLTH0E15268g Lachancea thermotolerans CBS 6340 KLTH0E15268p XP_002554143.1 1353439 R 559295 CDS KLTH0E15290g 255715725 8292315 1354807..1355265 1 NC_013081.1 highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism; KLTH0E15290p 1355265 8292315 KLTH0E15290g Lachancea thermotolerans CBS 6340 KLTH0E15290p XP_002554144.1 1354807 D 559295 CDS KLTH0E15312g 255715727 8292316 complement(join(1355420..1355711,1355784..1355818)) 1 NC_013081.1 weakly similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C Hypothetical ORF; KLTH0E15312p 1355818 8292316 KLTH0E15312g Lachancea thermotolerans CBS 6340 KLTH0E15312p XP_002554145.1 1355420 R 559295 CDS KLTH0E15334g 255715729 8292317 complement(1356128..1357099) 1 NC_013081.1 weakly similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein; KLTH0E15334p 1357099 8292317 KLTH0E15334g Lachancea thermotolerans CBS 6340 KLTH0E15334p XP_002554146.1 1356128 R 559295 CDS KLTH0E15356g 255715731 8292318 1358408..1361356 1 NC_013081.1 some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein predicted to have 5 transmembrane segments; KLTH0E15356p 1361356 8292318 KLTH0E15356g Lachancea thermotolerans CBS 6340 KLTH0E15356p XP_002554147.1 1358408 D 559295 CDS KLTH0E15378g 255715733 8292319 1361681..1366972 1 NC_013081.1 similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0E15378p 1366972 8292319 KLTH0E15378g Lachancea thermotolerans CBS 6340 KLTH0E15378p XP_002554148.1 1361681 D 559295 CDS KLTH0E15400g 255715735 8292320 1367192..1367926 1 NC_013081.1 similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function interacts with Gea1p and Gea2p required for localization of Gea2p computational analysis suggests a possible role in either cell wall synthesis or protein- vacuolar targeting; KLTH0E15400p 1367926 8292320 KLTH0E15400g Lachancea thermotolerans CBS 6340 KLTH0E15400p XP_002554149.1 1367192 D 559295 CDS KLTH0E15422g 255715737 8292321 complement(1368027..1368455) 1 NC_013081.1 conserved hypothetical protein; KLTH0E15422p 1368455 8292321 KLTH0E15422g Lachancea thermotolerans CBS 6340 KLTH0E15422p XP_002554150.1 1368027 R 559295 CDS KLTH0E15444g 255715739 8292322 complement(1369017..1370666) 1 NC_013081.1 conserved hypothetical protein; KLTH0E15444p 1370666 8292322 KLTH0E15444g Lachancea thermotolerans CBS 6340 KLTH0E15444p XP_002554151.1 1369017 R 559295 CDS KLTH0E15466g 255715741 8292323 complement(1371690..1376333) 1 NC_013081.1 similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D catalyzes the hydrolysis of phosphatidylcholine producing choline and phosphatidic acid involved in Sec14p-independent secretion required for meiosis and spore formation differently regulated in secretion and meiosis; KLTH0E15466p 1376333 8292323 KLTH0E15466g Lachancea thermotolerans CBS 6340 KLTH0E15466p XP_002554152.1 1371690 R 559295 CDS KLTH0E15488g 255715743 8292324 1377607..1379232 1 NC_013081.1 some similarities with uniprot|P42944 Saccharomyces cerevisiae YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p; KLTH0E15488p 1379232 8292324 KLTH0E15488g Lachancea thermotolerans CBS 6340 KLTH0E15488p XP_002554153.1 1377607 D 559295 CDS KLTH0E15510g 255715745 8292325 1379514..1380131 1 NC_013081.1 highly similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway associates reversibly with the late endosome has human ortholog that may be altered in breast tumors; KLTH0E15510p 1380131 8292325 KLTH0E15510g Lachancea thermotolerans CBS 6340 KLTH0E15510p XP_002554154.1 1379514 D 559295 CDS KLTH0E15532g 255715747 8292326 complement(1380466..1381395) 1 NC_013081.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism; KLTH0E15532p 1381395 8292326 KLTH0E15532g Lachancea thermotolerans CBS 6340 KLTH0E15532p XP_002554155.1 1380466 R 559295 CDS KLTH0E15554g 255715749 8292327 complement(1382072..1383718) 1 NC_013081.1 highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0E15554p 1383718 8292327 KLTH0E15554g Lachancea thermotolerans CBS 6340 KLTH0E15554p XP_002554156.1 1382072 R 559295 CDS KLTH0E15576g 255715751 8292328 complement(1384027..1386198) 1 NC_013081.1 similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W MDV1 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission; KLTH0E15576p 1386198 8292328 KLTH0E15576g Lachancea thermotolerans CBS 6340 KLTH0E15576p XP_002554157.1 1384027 R 559295 CDS KLTH0E15598g 255715753 8292329 complement(1386425..1387249) 1 NC_013081.1 similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle; KLTH0E15598p 1387249 8292329 KLTH0E15598g Lachancea thermotolerans CBS 6340 KLTH0E15598p XP_002554158.1 1386425 R 559295 CDS KLTH0E15620g 255715755 8292330 complement(1387410..1388564) 1 NC_013081.1 highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Putative glycoprotease that interacts with Bud32p which is a member of the novel protein kinase piD261 family; KLTH0E15620p 1388564 8292330 KLTH0E15620g Lachancea thermotolerans CBS 6340 KLTH0E15620p XP_002554159.1 1387410 R 559295 CDS KLTH0E15642g 255715757 8292331 1389937..1391727 1 NC_013081.1 similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source; KLTH0E15642p 1391727 8292331 KLTH0E15642g Lachancea thermotolerans CBS 6340 KLTH0E15642p XP_002554160.1 1389937 D 559295 CDS KLTH0E15664g 255715759 8292332 1391923..1393743 1 NC_013081.1 weakly similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W Hypothetical ORF; KLTH0E15664p 1393743 8292332 KLTH0E15664g Lachancea thermotolerans CBS 6340 KLTH0E15664p XP_002554161.1 1391923 D 559295 CDS KLTH0E15686g 255715761 8292333 1394071..1395162 1 NC_013081.1 highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4A; KLTH0E15686p 1395162 8292333 KLTH0E15686g Lachancea thermotolerans CBS 6340 KLTH0E15686p XP_002554162.1 1394071 D 559295 CDS KLTH0E15708g 255715763 8292334 complement(1395321..1396367) 1 NC_013081.1 highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants; KLTH0E15708p 1396367 8292334 KLTH0E15708g Lachancea thermotolerans CBS 6340 KLTH0E15708p XP_002554163.1 1395321 R 559295 CDS KLTH0E15730g 255715765 8292335 complement(1396500..1398224) 1 NC_013081.1 similar to uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal; KLTH0E15730p 1398224 8292335 KLTH0E15730g Lachancea thermotolerans CBS 6340 KLTH0E15730p XP_002554164.1 1396500 R 559295 CDS KLTH0E15752g 255715767 8292336 1398329..1399156 1 NC_013081.1 similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF; KLTH0E15752p 1399156 8292336 KLTH0E15752g Lachancea thermotolerans CBS 6340 KLTH0E15752p XP_002554165.1 1398329 D 559295 CDS KLTH0E15774g 255715769 8292337 complement(1399188..1399766) 1 NC_013081.1 highly similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co- chaperone GimC/prefoldin complex which promotes efficient protein folding; KLTH0E15774p 1399766 8292337 KLTH0E15774g Lachancea thermotolerans CBS 6340 KLTH0E15774p XP_002554166.1 1399188 R 559295 CDS KLTH0E15796g 255715771 8292338 1400194..1403937 1 NC_013081.1 similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF; KLTH0E15796p 1403937 8292338 KLTH0E15796g Lachancea thermotolerans CBS 6340 KLTH0E15796p XP_002554167.1 1400194 D 559295 CDS KLTH0E15818g 255715773 8292339 complement(1404334..1405650) 1 NC_013081.1 weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p; KLTH0E15818p 1405650 8292339 KLTH0E15818g Lachancea thermotolerans CBS 6340 KLTH0E15818p XP_002554168.1 1404334 R 559295 CDS KLTH0E15840g 255715775 8292340 join(1406256..1406303,1406400..1406693) 1 NC_013081.1 similar to uniprot|Q12489 Saccharomyces cerevisiae YDL012C Plasma membrane protein of unknown function; KLTH0E15840p 1406693 8292340 KLTH0E15840g Lachancea thermotolerans CBS 6340 KLTH0E15840p XP_002554169.1 1406256 D 559295 CDS KLTH0E15862g 255715777 8292341 complement(1406851..1407957) 1 NC_013081.1 conserved hypothetical protein; KLTH0E15862p 1407957 8292341 KLTH0E15862g Lachancea thermotolerans CBS 6340 KLTH0E15862p XP_002554170.1 1406851 R 559295 CDS KLTH0E15884g 255715779 8292342 complement(1408264..1410024) 1 NC_013081.1 similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p; KLTH0E15884p 1410024 8292342 KLTH0E15884g Lachancea thermotolerans CBS 6340 KLTH0E15884p XP_002554171.1 1408264 R 559295 CDS KLTH0E15906g 255715781 8292343 complement(1410389..1411423) 1 NC_013081.1 similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W; KLTH0E15906p 1411423 8292343 KLTH0E15906g Lachancea thermotolerans CBS 6340 KLTH0E15906p XP_002554172.1 1410389 R 559295 CDS KLTH0E15928g 255715783 8292344 1412457..1413392 1 NC_013081.1 conserved hypothetical protein; KLTH0E15928p 1413392 8292344 KLTH0E15928g Lachancea thermotolerans CBS 6340 KLTH0E15928p XP_002554173.1 1412457 D 559295 CDS KLTH0E15950g 255715785 8292345 1413596..1414513 1 NC_013081.1 similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis; KLTH0E15950p 1414513 8292345 KLTH0E15950g Lachancea thermotolerans CBS 6340 KLTH0E15950p XP_002554174.1 1413596 D 559295 CDS KLTH0E15972g 255715787 8292346 complement(1414595..1416016) 1 NC_013081.1 similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression; KLTH0E15972p 1416016 8292346 KLTH0E15972g Lachancea thermotolerans CBS 6340 KLTH0E15972p XP_002554175.1 1414595 R 559295 CDS KLTH0E15994g 255715789 8292347 1416153..1416794 1 NC_013081.1 similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C; KLTH0E15994p 1416794 8292347 KLTH0E15994g Lachancea thermotolerans CBS 6340 KLTH0E15994p XP_002554176.1 1416153 D 559295 CDS KLTH0E16016g 255715791 8292348 complement(1416852..1418480) 1 NC_013081.1 weakly similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression; KLTH0E16016p 1418480 8292348 KLTH0E16016g Lachancea thermotolerans CBS 6340 KLTH0E16016p XP_002554177.1 1416852 R 559295 CDS KLTH0E16038g 255715793 8292349 complement(1419016..1421715) 1 NC_013081.1 similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg- nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression; KLTH0E16038p 1421715 8292349 KLTH0E16038g Lachancea thermotolerans CBS 6340 KLTH0E16038p XP_002554178.1 1419016 R 559295 CDS KLTH0E16060g 255715795 8292350 complement(1422204..1424144) 1 NC_013081.1 weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0E16060p 1424144 8292350 KLTH0E16060g Lachancea thermotolerans CBS 6340 KLTH0E16060p XP_002554179.1 1422204 R 559295 CDS KLTH0E16082g 255715797 8292351 1424803..1425717 1 NC_013081.1 highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4- carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenine; KLTH0E16082p 1425717 8292351 KLTH0E16082g Lachancea thermotolerans CBS 6340 KLTH0E16082p XP_002554180.1 1424803 D 559295 CDS KLTH0E16104g 255715799 8292352 complement(1425822..1427042) 1 NC_013081.1 similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role; KLTH0E16104p 1427042 8292352 KLTH0E16104g Lachancea thermotolerans CBS 6340 KLTH0E16104p XP_002554181.1 1425822 R 559295 CDS KLTH0E16126g 255715801 8292353 complement(1427208..1429814) 1 NC_013081.1 similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p; KLTH0E16126p 1429814 8292353 KLTH0E16126g Lachancea thermotolerans CBS 6340 KLTH0E16126p XP_002554182.1 1427208 R 559295 CDS KLTH0E16148g 255715803 8292354 1431414..1435082 1 NC_013081.1 similar to uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; KLTH0E16148p 1435082 8292354 KLTH0E16148g Lachancea thermotolerans CBS 6340 KLTH0E16148p XP_002554183.1 1431414 D 559295 CDS KLTH0E16192g 255715805 8292356 join(1436277..1436378,1436568..1437860) 1 NC_013081.1 highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA involved in the second step in mevalonate biosynthesis; KLTH0E16192p 1437860 8292356 KLTH0E16192g Lachancea thermotolerans CBS 6340 KLTH0E16192p XP_002554184.1 1436277 D 559295 CDS KLTH0E16214g 255715807 8292357 1438285..1441866 1 NC_013081.1 similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein component of mitochondrial RNase P along with the mitochondrially-encoded RNA subunit RPM1 Rnase P removes 5' extensions from tRNA precursors Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs; KLTH0E16214p 1441866 8292357 KLTH0E16214g Lachancea thermotolerans CBS 6340 KLTH0E16214p XP_002554185.1 1438285 D 559295 CDS KLTH0E16236g 255715809 8292358 complement(1442142..1443884) 1 NC_013081.1 similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; KLTH0E16236p 1443884 8292358 KLTH0E16236g Lachancea thermotolerans CBS 6340 KLTH0E16236p XP_002554186.1 1442142 R 559295 CDS KLTH0E16258g 255715811 8292359 1444885..1447011 1 NC_013081.1 similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc1 mutants are defective in directing meiotic recombination events to homologous chromatids; KLTH0E16258p 1447011 8292359 KLTH0E16258g Lachancea thermotolerans CBS 6340 KLTH0E16258p XP_002554187.1 1444885 D 559295 CDS KLTH0E16280g 255715813 8292360 complement(join(1447731..1448369,1448424..1448429)) 1 NC_013081.1 conserved hypothetical protein; KLTH0E16280p 1448429 8292360 KLTH0E16280g Lachancea thermotolerans CBS 6340 KLTH0E16280p XP_002554188.1 1447731 R 559295 CDS KLTH0E16302g 255715815 8292361 1449574..1450143 1 NC_013081.1 conserved hypothetical protein; KLTH0E16302p 1450143 8292361 KLTH0E16302g Lachancea thermotolerans CBS 6340 KLTH0E16302p XP_002554189.1 1449574 D 559295 CDS KLTH0E16324g 255715817 8292362 join(1450336..1450379,1450467..1451175) 1 NC_013081.1 similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 20S proteasome beta-type subunit; KLTH0E16324p 1451175 8292362 KLTH0E16324g Lachancea thermotolerans CBS 6340 KLTH0E16324p XP_002554190.1 1450336 D 559295 CDS KLTH0E16346g 255715819 8292363 complement(1451260..1453902) 1 NC_013081.1 similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0E16346p 1453902 8292363 KLTH0E16346g Lachancea thermotolerans CBS 6340 KLTH0E16346p XP_002554191.1 1451260 R 559295 CDS KLTH0E16368g 255715821 8292364 complement(join(1454035..1454492,1454564..1454579)) 1 NC_013081.1 highly similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; KLTH0E16368p 1454579 8292364 KLTH0E16368g Lachancea thermotolerans CBS 6340 KLTH0E16368p XP_002554192.1 1454035 R 559295 CDS KLTH0E16390g 255715823 8292365 1454675..1455289 1 NC_013081.1 similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p) cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) homolog of human XPF protein; KLTH0E16390p 1455289 8292365 KLTH0E16390g Lachancea thermotolerans CBS 6340 KLTH0E16390p XP_002554193.1 1454675 D 559295 CDS KLTH0E16412g 255715825 8292366 complement(1455298..1456845) 1 NC_013081.1 similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Hypothetical ORF; KLTH0E16412p 1456845 8292366 KLTH0E16412g Lachancea thermotolerans CBS 6340 KLTH0E16412p XP_002554194.1 1455298 R 559295 CDS KLTH0E16434g 255715827 8292367 1456940..1458247 1 NC_013081.1 similar to uniprot|P54787 Saccharomyces cerevisiae YML097C; KLTH0E16434p 1458247 8292367 KLTH0E16434g Lachancea thermotolerans CBS 6340 KLTH0E16434p XP_002554195.1 1456940 D 559295 CDS KLTH0E16456g 255715829 8292368 1458414..1460105 1 NC_013081.1 similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum; KLTH0E16456p 1460105 8292368 KLTH0E16456g Lachancea thermotolerans CBS 6340 KLTH0E16456p XP_002554196.1 1458414 D 559295 CDS KLTH0E16478g 255715831 8292369 complement(1460258..1460734) 1 NC_013081.1 similar to uniprot|P11747 Saccharomyces cerevisiae YML098W; KLTH0E16478p 1460734 8292369 KLTH0E16478g Lachancea thermotolerans CBS 6340 KLTH0E16478p XP_002554197.1 1460258 R 559295 CDS KLTH0E16500g 255715833 8292370 1460844..1463345 1 NC_013081.1 similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p; KLTH0E16500p 1463345 8292370 KLTH0E16500g Lachancea thermotolerans CBS 6340 KLTH0E16500p XP_002554198.1 1460844 D 559295 CDS KLTH0E16522g 255715835 8292371 1463656..1464708 1 NC_013081.1 highly similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF; KLTH0E16522p 1464708 8292371 KLTH0E16522g Lachancea thermotolerans CBS 6340 KLTH0E16522p XP_002554199.1 1463656 D 559295 CDS KLTH0E16544g 255715837 8292372 1465401..1466603 1 NC_013081.1 similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response; KLTH0E16544p 1466603 8292372 KLTH0E16544g Lachancea thermotolerans CBS 6340 KLTH0E16544p XP_002554200.1 1465401 D 559295 CDS KLTH0E16566g 255715839 8292373 1468783..1469928 1 NC_013081.1 similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF; KLTH0E16566p 1469928 8292373 KLTH0E16566g Lachancea thermotolerans CBS 6340 KLTH0E16566p XP_002554201.1 1468783 D 559295 CDS KLTH0E16588g 255715841 8292374 complement(1470414..1472027) 1 NC_013081.1 similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression; KLTH0E16588p 1472027 8292374 KLTH0E16588g Lachancea thermotolerans CBS 6340 KLTH0E16588p XP_002554202.1 1470414 R 559295 CDS KLTH0E16610g 255715843 8292375 complement(1472723..1474417) 1 NC_013081.1 conserved hypothetical protein; KLTH0E16610p 1474417 8292375 KLTH0E16610g Lachancea thermotolerans CBS 6340 KLTH0E16610p XP_002554203.1 1472723 R 559295 CDS KLTH0E16632g 255715845 8292376 complement(1475624..1476100) 1 NC_013081.1 similar to uniprot|Q08906 Saccharomyces cerevisiae YOR382W FIT2 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor involved in the retention of siderophore-iron in the cell wall; KLTH0E16632p 1476100 8292376 KLTH0E16632g Lachancea thermotolerans CBS 6340 KLTH0E16632p XP_002554204.1 1475624 R 559295 CDS KLTH0E16654g 255715847 8292377 complement(1477110..1477760) 1 NC_013081.1 similar to uniprot|Q08907 Saccharomyces cerevisiae YOR383C FIT3 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor involved in the retention of siderophore-iron in the cell wall; KLTH0E16654p 1477760 8292377 KLTH0E16654g Lachancea thermotolerans CBS 6340 KLTH0E16654p XP_002554205.1 1477110 R 559295 CDS KLTH0E16676g 255715849 8292378 1478547..1480610 1 NC_013081.1 similar to uniprot|Q08908 Saccharomyces cerevisiae YOR384W; KLTH0E16676p 1480610 8292378 KLTH0E16676g Lachancea thermotolerans CBS 6340 KLTH0E16676p XP_002554206.1 1478547 D 559295 CDS KLTH0E16720g 255715851 8292380 1482846..1484570 1 NC_013081.1 similar to uniprot|P38358 Saccharomyces cerevisiae YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane; KLTH0E16720p 1484570 8292380 KLTH0E16720g Lachancea thermotolerans CBS 6340 KLTH0E16720p XP_002554207.1 1482846 D 559295 CDS KLTH0E16742g 255715853 8292381 complement(1484874..1485563) 1 NC_013081.1 conserved hypothetical protein; KLTH0E16742p 1485563 8292381 KLTH0E16742g Lachancea thermotolerans CBS 6340 KLTH0E16742p XP_002554208.1 1484874 R 559295 CDS KLTH0E16764g 255715855 8292382 1486052..1487371 1 NC_013081.1 weakly similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux major facilitator superfamily protein; KLTH0E16764p 1487371 8292382 KLTH0E16764g Lachancea thermotolerans CBS 6340 KLTH0E16764p XP_002554209.1 1486052 D 559295 CDS KLTH0E16786g 255715857 8292383 complement(1488384..1489088) 1 NC_013081.1 highly similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S- transferase capable of homodimerization expression induced during the diauxic shift and throughout stationary phase functional overlap with Gtt2p Grx1p and Grx2p; KLTH0E16786p 1489088 8292383 KLTH0E16786g Lachancea thermotolerans CBS 6340 KLTH0E16786p XP_002554210.1 1488384 R 559295 CDS KLTH0E16808g 255715859 8292384 1490795..1492495 1 NC_013081.1 some similarities with uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane; KLTH0E16808p 1492495 8292384 KLTH0E16808g Lachancea thermotolerans CBS 6340 KLTH0E16808p XP_002554211.1 1490795 D 559295 CDS KLTH0E16852g 255715861 8292386 complement(1496072..1497199) 1 NC_013081.1 highly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C; KLTH0E16852p 1497199 8292386 KLTH0E16852g Lachancea thermotolerans CBS 6340 KLTH0E16852p XP_002554212.1 1496072 R 559295 CDS KLTH0E16874g 255715863 8292387 complement(1497920..1499245) 1 NC_013081.1 highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF; KLTH0E16874p 1499245 8292387 KLTH0E16874g Lachancea thermotolerans CBS 6340 KLTH0E16874p XP_002554213.1 1497920 R 559295 CDS KLTH0E16984g 255715865 8292392 complement(1508741..1510360) 1 NC_013081.1 highly similar to uniprot|P38156 Saccharomyces cerevisiae YBR298C MAL31 Maltose permease high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL3 complex locus member of the 12 transmembrane domain superfamily of sugar transporters functional in genomic reference strain S288C; KLTH0E16984p 1510360 8292392 KLTH0E16984g Lachancea thermotolerans CBS 6340 KLTH0E16984p XP_002554214.1 1508741 R 559295 CDS KLTH0E17006g 255715867 8292393 1511206..1512960 1 NC_013081.1 highly similar to uniprot|P53341 Saccharomyces cerevisiae YGR292W MAL12 Maltase (alpha-D-glucosidase) inducible protein involved in maltose catabolism encoded in the MAL1 complex locus; KLTH0E17006p 1512960 8292393 KLTH0E17006g Lachancea thermotolerans CBS 6340 KLTH0E17006p XP_002554215.1 1511206 D 559295 CDS KLTH0E17138g 255715869 8292398 1518674..1519888 1 NC_013081.1 some similarities with uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 ATP binding cassette (ABC) transporter of the plasma membrane general stress response factor implicated in cellular detoxification target of Pdr1p Pdr3p and Pdr8p transcription regulators promoter contains a PDR responsive element; KLTH0E17138p 1519888 8292398 KLTH0E17138g Lachancea thermotolerans CBS 6340 KLTH0E17138p XP_002554216.1 1518674 D 559295 CDS KLTH0F00110g 255715872 8292403 complement(4885..5721) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00110p 5721 8292403 KLTH0F00110g Lachancea thermotolerans CBS 6340 KLTH0F00110p XP_002554217.1 4885 R 559295 CDS KLTH0F00132g 255715874 8292404 complement(6732..7352) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00132p 7352 8292404 KLTH0F00132g Lachancea thermotolerans CBS 6340 KLTH0F00132p XP_002554218.1 6732 R 559295 CDS KLTH0F00176g 255715876 8292406 complement(18324..18956) 1 NC_013082.1 similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W Hypothetical ORF; KLTH0F00176p 18956 8292406 KLTH0F00176g Lachancea thermotolerans CBS 6340 KLTH0F00176p XP_002554219.1 18324 R 559295 CDS KLTH0F00242g 255715878 8292409 complement(21856..22284) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00242p 22284 8292409 KLTH0F00242g Lachancea thermotolerans CBS 6340 KLTH0F00242p XP_002554220.1 21856 R 559295 CDS KLTH0F00264g 255715880 8292410 22655..23332 1 NC_013082.1 conserved hypothetical protein; KLTH0F00264p 23332 8292410 KLTH0F00264g Lachancea thermotolerans CBS 6340 KLTH0F00264p XP_002554221.1 22655 D 559295 CDS KLTH0F00308g 255715882 8292412 complement(26133..27077) 1 NC_013082.1 highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid dihydroorotate dehydrogenase; KLTH0F00308p 27077 8292412 KLTH0F00308g Lachancea thermotolerans CBS 6340 KLTH0F00308p XP_002554222.1 26133 R 559295 CDS KLTH0F00330g 255715884 8292413 complement(27980..28891) 1 NC_013082.1 similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family; KLTH0F00330p 28891 8292413 KLTH0F00330g Lachancea thermotolerans CBS 6340 KLTH0F00330p XP_002554223.1 27980 R 559295 CDS KLTH0F00352g 255715886 8292414 join(30187..30250,30300..30670) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00352p 30670 8292414 KLTH0F00352g Lachancea thermotolerans CBS 6340 KLTH0F00352p XP_002554224.1 30187 D 559295 CDS KLTH0F00374g 255715888 8292415 complement(30927..31676) 1 NC_013082.1 weakly similar to uniprot|P01365 Saccharomyces cerevisiae YCR040W MATALPHA1 Transcriptional co-activator involved in regulation of mating-type-specific gene expression targets the transcription factor Mcm1p to the promoters of alpha-specific genes one of two genes encoded by the alpha mating type cassette; KLTH0F00374p 31676 8292415 KLTH0F00374g Lachancea thermotolerans CBS 6340 KLTH0F00374p XP_002554225.1 30927 R 559295 CDS KLTH0F00396g 255715890 8292416 join(31990..32051,32348..32612) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00396p 32612 8292416 KLTH0F00396g Lachancea thermotolerans CBS 6340 KLTH0F00396p XP_002554226.1 31990 D 559295 CDS KLTH0F00440g 255715892 8292418 complement(34215..35240) 1 NC_013082.1 similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase; KLTH0F00440p 35240 8292418 KLTH0F00440g Lachancea thermotolerans CBS 6340 KLTH0F00440p XP_002554227.1 34215 R 559295 CDS KLTH0F00462g 255715894 8292419 35640..36995 1 NC_013082.1 weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance; KLTH0F00462p 36995 8292419 KLTH0F00462g Lachancea thermotolerans CBS 6340 KLTH0F00462p XP_002554228.1 35640 D 559295 CDS KLTH0F00484g 255715896 8292420 complement(37017..39998) 1 NC_013082.1 weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint; KLTH0F00484p 39998 8292420 KLTH0F00484g Lachancea thermotolerans CBS 6340 KLTH0F00484p XP_002554229.1 37017 R 559295 CDS KLTH0F00506g 255715898 8292421 complement(40222..41220) 1 NC_013082.1 highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; KLTH0F00506p 41220 8292421 KLTH0F00506g Lachancea thermotolerans CBS 6340 KLTH0F00506p XP_002554230.1 40222 R 559295 CDS KLTH0F00528g 255715900 8292422 41595..41909 1 NC_013082.1 conserved hypothetical protein; KLTH0F00528p 41909 8292422 KLTH0F00528g Lachancea thermotolerans CBS 6340 KLTH0F00528p XP_002554231.1 41595 D 559295 CDS KLTH0F00550g 255715902 8292423 complement(42092..42340) 1 NC_013082.1 similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A; KLTH0F00550p 42340 8292423 KLTH0F00550g Lachancea thermotolerans CBS 6340 KLTH0F00550p XP_002554232.1 42092 R 559295 CDS KLTH0F00572g 255715904 8292424 complement(42946..43533) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00572p 43533 8292424 KLTH0F00572g Lachancea thermotolerans CBS 6340 KLTH0F00572p XP_002554233.1 42946 R 559295 CDS KLTH0F00594g 255715906 8292425 complement(43649..44950) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00594p 44950 8292425 KLTH0F00594g Lachancea thermotolerans CBS 6340 KLTH0F00594p XP_002554234.1 43649 R 559295 CDS KLTH0F00616g 255715908 8292426 46437..47438 1 NC_013082.1 conserved hypothetical protein; KLTH0F00616p 47438 8292426 KLTH0F00616g Lachancea thermotolerans CBS 6340 KLTH0F00616p XP_002554235.1 46437 D 559295 CDS KLTH0F00638g 255715910 8292427 47778..50513 1 NC_013082.1 weakly similar to uniprot|P37020 Saccharomyces cerevisiae YJR040w; KLTH0F00638p 50513 8292427 KLTH0F00638g Lachancea thermotolerans CBS 6340 KLTH0F00638p XP_002554236.1 47778 D 559295 CDS KLTH0F00660g 255715912 8292428 51436..52404 1 NC_013082.1 similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KAR4 Transcription factor required for induction of KAR3 and CIK1 during mating also required during meiosis exists in two forms a slower-migrating form more abundant during vegetative growth and a faster- migrating form induced by pheromone; KLTH0F00660p 52404 8292428 KLTH0F00660g Lachancea thermotolerans CBS 6340 KLTH0F00660p XP_002554237.1 51436 D 559295 CDS KLTH0F00682g 255715914 8292429 complement(52524..54041) 1 NC_013082.1 conserved hypothetical protein; KLTH0F00682p 54041 8292429 KLTH0F00682g Lachancea thermotolerans CBS 6340 KLTH0F00682p XP_002554238.1 52524 R 559295 CDS KLTH0F00704g 255715916 8292430 55161..57653 1 NC_013082.1 similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants; KLTH0F00704p 57653 8292430 KLTH0F00704g Lachancea thermotolerans CBS 6340 KLTH0F00704p XP_002554239.1 55161 D 559295 CDS KLTH0F00726g 255715918 8292431 complement(57703..58947) 1 NC_013082.1 similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X; KLTH0F00726p 58947 8292431 KLTH0F00726g Lachancea thermotolerans CBS 6340 KLTH0F00726p XP_002554240.1 57703 R 559295 CDS KLTH0F00748g 255715920 8292432 59375..60589 1 NC_013082.1 some similarities with uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes; KLTH0F00748p 60589 8292432 KLTH0F00748g Lachancea thermotolerans CBS 6340 KLTH0F00748p XP_002554241.1 59375 D 559295 CDS KLTH0F00770g 255715922 8292433 complement(60934..61320) 1 NC_013082.1 similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C; KLTH0F00770p 61320 8292433 KLTH0F00770g Lachancea thermotolerans CBS 6340 KLTH0F00770p XP_002554242.1 60934 R 559295 CDS KLTH0F00792g 255715924 8292434 complement(61554..62507) 1 NC_013082.1 similar to uniprot|P16550 Saccharomyces cerevisiae YCL050C APA1 and similar to uniprot|P22108 Saccharomyces cerevisiae YDR530C APA2; KLTH0F00792p 62507 8292434 KLTH0F00792g Lachancea thermotolerans CBS 6340 KLTH0F00792p XP_002554243.1 61554 R 559295 CDS KLTH0F00814g 255715926 8292435 62916..63986 1 NC_013082.1 KLTH0F00814p 63986 8292435 KLTH0F00814g Lachancea thermotolerans CBS 6340 KLTH0F00814p XP_002554244.1 62916 D 559295 CDS KLTH0F00836g 255715928 8292436 complement(64053..65141) 1 NC_013082.1 weakly similar to uniprot|Q6Q537 Saccharomyces cerevisiae YDR532C Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles forms a complex with Spc105p; KLTH0F00836p 65141 8292436 KLTH0F00836g Lachancea thermotolerans CBS 6340 KLTH0F00836p XP_002554245.1 64053 R 559295 CDS KLTH0F00858g 255715930 8292437 complement(65935..67287) 1 NC_013082.1 similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W; KLTH0F00858p 67287 8292437 KLTH0F00858g Lachancea thermotolerans CBS 6340 KLTH0F00858p XP_002554246.1 65935 R 559295 CDS KLTH0F00880g 255715932 8292438 complement(67565..67795) 1 NC_013082.1 similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A; KLTH0F00880p 67795 8292438 KLTH0F00880g Lachancea thermotolerans CBS 6340 KLTH0F00880p XP_002554247.1 67565 R 559295 CDS KLTH0F00902g 255715934 8292439 complement(67984..68829) 1 NC_013082.1 similar to uniprot|P32460 Saccharomyces cerevisiae YIR030C DCG1 Protein of unknown function expression is sensitive to nitrogen catabolite repression and regulated by Dal80p contains transmembrane domain; KLTH0F00902p 68829 8292439 KLTH0F00902g Lachancea thermotolerans CBS 6340 KLTH0F00902p XP_002554248.1 67984 R 559295 CDS KLTH0F00924g 255715936 8292440 70601..73144 1 NC_013082.1 some similarities with uniprot|Q04412 Saccharomyces cerevisiae YDR524C AGE1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s); KLTH0F00924p 73144 8292440 KLTH0F00924g Lachancea thermotolerans CBS 6340 KLTH0F00924p XP_002554249.1 70601 D 559295 CDS KLTH0F00946g 255715938 8292441 73412..74950 1 NC_013082.1 similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis; KLTH0F00946p 74950 8292441 KLTH0F00946g Lachancea thermotolerans CBS 6340 KLTH0F00946p XP_002554250.1 73412 D 559295 CDS KLTH0F00968g 255715940 8292442 75236..76672 1 NC_013082.1 similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta- glucan layer of the spore wall and similar to YDR522c uniprot|P08459 Saccharomyces cerevisiae YDR522C SPS2 Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall and weakly similar to YBR078w uniprot|P38248 Saccharomyces cerevisiae YBR078W ECM3 GPI-anchored protein of unknown function and weakly similar to YDR055w uniprot|Q12355 Saccharomyces cerevisiae YDR055W PST1 Cell wall protein that contains a putative GPI-attachment site; KLTH0F00968p 76672 8292442 KLTH0F00968g Lachancea thermotolerans CBS 6340 KLTH0F00968p XP_002554251.1 75236 D 559295 CDS KLTH0F00990g 255715942 8292443 77084..79441 1 NC_013082.1 similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF; KLTH0F00990p 79441 8292443 KLTH0F00990g Lachancea thermotolerans CBS 6340 KLTH0F00990p XP_002554252.1 77084 D 559295 CDS KLTH0F01012g 255715944 8292444 complement(79475..80266) 1 NC_013082.1 similar to uniprot|P25576 Saccharomyces cerevisiae YCL047C Hypothetical ORF; KLTH0F01012p 80266 8292444 KLTH0F01012g Lachancea thermotolerans CBS 6340 KLTH0F01012p XP_002554253.1 79475 R 559295 CDS KLTH0F01034g 255715946 8292445 complement(80327..80752) 1 NC_013082.1 similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis- trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking; KLTH0F01034p 80752 8292445 KLTH0F01034g Lachancea thermotolerans CBS 6340 KLTH0F01034p XP_002554254.1 80327 R 559295 CDS KLTH0F01056g 255715948 8292446 complement(80904..83219) 1 NC_013082.1 similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C; KLTH0F01056p 83219 8292446 KLTH0F01056g Lachancea thermotolerans CBS 6340 KLTH0F01056p XP_002554255.1 80904 R 559295 CDS KLTH0F01078g 255715950 8292447 complement(83274..84608) 1 NC_013082.1 similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C; KLTH0F01078p 84608 8292447 KLTH0F01078g Lachancea thermotolerans CBS 6340 KLTH0F01078p XP_002554256.1 83274 R 559295 CDS KLTH0F01100g 255715952 8292448 complement(84685..86250) 1 NC_013082.1 similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI1 Protein disulfide isomerase and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518w EUG1; KLTH0F01100p 86250 8292448 KLTH0F01100g Lachancea thermotolerans CBS 6340 KLTH0F01100p XP_002554257.1 84685 R 559295 CDS KLTH0F01122g 255715954 8292449 complement(86725..87819) 1 NC_013082.1 similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks; KLTH0F01122p 87819 8292449 KLTH0F01122g Lachancea thermotolerans CBS 6340 KLTH0F01122p XP_002554258.1 86725 R 559295 CDS KLTH0F01144g 255715956 8292450 88845..90329 1 NC_013082.1 highly similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non- fermentable carbon sources; KLTH0F01144p 90329 8292450 KLTH0F01144g Lachancea thermotolerans CBS 6340 KLTH0F01144p XP_002554259.1 88845 D 559295 CDS KLTH0F01166g 255715958 8292451 90708..92939 1 NC_013082.1 similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W; KLTH0F01166p 92939 8292451 KLTH0F01166g Lachancea thermotolerans CBS 6340 KLTH0F01166p XP_002554260.1 90708 D 559295 CDS KLTH0F01188g 255715960 8292452 complement(92980..94491) 1 NC_013082.1 similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole; KLTH0F01188p 94491 8292452 KLTH0F01188g Lachancea thermotolerans CBS 6340 KLTH0F01188p XP_002554261.1 92980 R 559295 CDS KLTH0F01210g 255715962 8292453 complement(95054..96409) 1 NC_013082.1 weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9; KLTH0F01210p 96409 8292453 KLTH0F01210g Lachancea thermotolerans CBS 6340 KLTH0F01210p XP_002554262.1 95054 R 559295 CDS KLTH0F01232g 255715964 8292454 96822..98216 1 NC_013082.1 similar to uniprot|P25370 Saccharomyces cerevisiae YDR514C Hypothetical ORF and similar to YCL036w; KLTH0F01232p 98216 8292454 KLTH0F01232g Lachancea thermotolerans CBS 6340 KLTH0F01232p XP_002554263.1 96822 D 559295 CDS KLTH0F01254g 255715966 8292455 98944..100686 1 NC_013082.1 some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C; KLTH0F01254p 100686 8292455 KLTH0F01254g Lachancea thermotolerans CBS 6340 KLTH0F01254p XP_002554264.1 98944 D 559295 CDS KLTH0F01276g 255715968 8292456 complement(101034..101450) 1 NC_013082.1 similar to uniprot|P25373 Saccharomyces cerevisiae YCL035C GRX1 and similar to uniprot|P17695 Saccharomyces cerevisiae YDR513w TTR1; KLTH0F01276p 101450 8292456 KLTH0F01276g Lachancea thermotolerans CBS 6340 KLTH0F01276p XP_002554265.1 101034 R 559295 CDS KLTH0F01298g 255715970 8292457 101766..102758 1 NC_013082.1 similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; KLTH0F01298p 102758 8292457 KLTH0F01298g Lachancea thermotolerans CBS 6340 KLTH0F01298p XP_002554266.1 101766 D 559295 CDS KLTH0F01320g 255715972 8292458 complement(102876..103376) 1 NC_013082.1 similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF; KLTH0F01320p 103376 8292458 KLTH0F01320g Lachancea thermotolerans CBS 6340 KLTH0F01320p XP_002554267.1 102876 R 559295 CDS KLTH0F01342g 255715974 8292459 103495..103752 1 NC_013082.1 some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C EMI1 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation; KLTH0F01342p 103752 8292459 KLTH0F01342g Lachancea thermotolerans CBS 6340 KLTH0F01342p XP_002554268.1 103495 D 559295 CDS KLTH0F01364g 255715976 8292460 103936..104844 1 NC_013082.1 similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; KLTH0F01364p 104844 8292460 KLTH0F01364g Lachancea thermotolerans CBS 6340 KLTH0F01364p XP_002554269.1 103936 D 559295 CDS KLTH0F01386g 255715978 8292461 complement(104933..105892) 1 NC_013082.1 similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing; KLTH0F01386p 105892 8292461 KLTH0F01386g Lachancea thermotolerans CBS 6340 KLTH0F01386p XP_002554270.1 104933 R 559295 CDS KLTH0F01408g 255715980 8292462 complement(106050..106442) 1 NC_013082.1 some similarities with uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes; KLTH0F01408p 106442 8292462 KLTH0F01408g Lachancea thermotolerans CBS 6340 KLTH0F01408p XP_002554271.1 106050 R 559295 CDS KLTH0F01430g 255715982 8292463 complement(106971..109406) 1 NC_013082.1 similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C; KLTH0F01430p 109406 8292463 KLTH0F01430g Lachancea thermotolerans CBS 6340 KLTH0F01430p XP_002554272.1 106971 R 559295 CDS KLTH0F01452g 255715984 8292464 complement(109643..110863) 1 NC_013082.1 similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170; KLTH0F01452p 110863 8292464 KLTH0F01452g Lachancea thermotolerans CBS 6340 KLTH0F01452p XP_002554273.1 109643 R 559295 CDS KLTH0F01474g 255715986 8292465 111050..111286 1 NC_013082.1 no similarity; KLTH0F01474p 111286 8292465 KLTH0F01474g Lachancea thermotolerans CBS 6340 KLTH0F01474p XP_002554274.1 111050 D 559295 CDS KLTH0F01496g 255715988 8292466 112409..113776 1 NC_013082.1 some similarities with uniprot|Q8TFP8 Saccharomyces cerevisiae YCL028W RNQ1; KLTH0F01496p 113776 8292466 KLTH0F01496g Lachancea thermotolerans CBS 6340 KLTH0F01496p XP_002554275.1 112409 D 559295 CDS KLTH0F01518g 255715990 8292467 complement(113886..115841) 1 NC_013082.1 some similarities with uniprot|P36110 Saccharomyces cerevisiae YKR013W; KLTH0F01518p 115841 8292467 KLTH0F01518g Lachancea thermotolerans CBS 6340 KLTH0F01518p XP_002554276.1 113886 R 559295 CDS KLTH0F01540g 255715992 8292468 117357..119114 1 NC_013082.1 weakly similar to uniprot|P11710 Saccharomyces cerevisiae YCL027W FUS1 Membrane protein localized to the shmoo tip required for cell fusion expression regulated by mating pheromone proposed to coordinate signaling fusion and polarization events required for fusion potential Cdc28p substrate; KLTH0F01540p 119114 8292468 KLTH0F01540g Lachancea thermotolerans CBS 6340 KLTH0F01540p XP_002554277.1 117357 D 559295 CDS KLTH0F01562g 255715994 8292469 complement(119234..119821) 1 NC_013082.1 similar to uniprot|Q96VH4 Saccharomyces cerevisiae YCL026C-B Hypothetical ORF; KLTH0F01562p 119821 8292469 KLTH0F01562g Lachancea thermotolerans CBS 6340 KLTH0F01562p XP_002554278.1 119234 R 559295 CDS KLTH0F01584g 255715996 8292470 complement(120227..122017) 1 NC_013082.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p- Ssy5p (SPS) sensor of extracellular amino acids; KLTH0F01584p 122017 8292470 KLTH0F01584g Lachancea thermotolerans CBS 6340 KLTH0F01584p XP_002554279.1 120227 R 559295 CDS KLTH0F01606g 255715998 8292471 complement(122821..124635) 1 NC_013082.1 similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p- Ssy5p (SPS) sensor of extracellular amino acids; KLTH0F01606p 124635 8292471 KLTH0F01606g Lachancea thermotolerans CBS 6340 KLTH0F01606p XP_002554280.1 122821 R 559295 CDS KLTH0F01628g 255716000 8292472 125692..126309 1 NC_013082.1 no similarity; KLTH0F01628p 126309 8292472 KLTH0F01628g Lachancea thermotolerans CBS 6340 KLTH0F01628p XP_002554281.1 125692 D 559295 CDS KLTH0F01650g 255716002 8292473 126388..126672 1 NC_013082.1 highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W; KLTH0F01650p 126672 8292473 KLTH0F01650g Lachancea thermotolerans CBS 6340 KLTH0F01650p XP_002554282.1 126388 D 559295 CDS KLTH0F01672g 255716004 8292474 127277..130771 1 NC_013082.1 similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C; KLTH0F01672p 130771 8292474 KLTH0F01672g Lachancea thermotolerans CBS 6340 KLTH0F01672p XP_002554283.1 127277 D 559295 CDS KLTH0F01694g 255716006 8292475 130898..132805 1 NC_013082.1 similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Hypothetical ORF; KLTH0F01694p 132805 8292475 KLTH0F01694g Lachancea thermotolerans CBS 6340 KLTH0F01694p XP_002554284.1 130898 D 559295 CDS KLTH0F01716g 255716008 8292476 133903..136104 1 NC_013082.1 similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and weakly similar to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; KLTH0F01716p 136104 8292476 KLTH0F01716g Lachancea thermotolerans CBS 6340 KLTH0F01716p XP_002554285.1 133903 D 559295 CDS KLTH0F01738g 255716010 8292477 complement(136381..137007) 1 NC_013082.1 similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation and to YLR179C uniprot|Q06252 Saccharomyces cerevisiae YLR179C Protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; KLTH0F01738p 137007 8292477 KLTH0F01738g Lachancea thermotolerans CBS 6340 KLTH0F01738p XP_002554286.1 136381 R 559295 CDS KLTH0F01760g 255716012 8292478 137634..138617 1 NC_013082.1 weakly similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2 )-independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA; KLTH0F01760p 138617 8292478 KLTH0F01760g Lachancea thermotolerans CBS 6340 KLTH0F01760p XP_002554287.1 137634 D 559295 CDS KLTH0F01782g 255716014 8292479 139467..140615 1 NC_013082.1 highly similar to uniprot|P10659 Saccharomyces cerevisiae YDR502C and to uniprot|P19358 SAM1 S- adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p); KLTH0F01782p 140615 8292479 KLTH0F01782g Lachancea thermotolerans CBS 6340 KLTH0F01782p XP_002554288.1 139467 D 559295 CDS KLTH0F01804g 255716016 8292480 complement(140897..142075) 1 NC_013082.1 similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled-coil domains mutants show class E vacuolar-protein sorting defects; KLTH0F01804p 142075 8292480 KLTH0F01804g Lachancea thermotolerans CBS 6340 KLTH0F01804p XP_002554289.1 140897 R 559295 CDS KLTH0F01826g 255716018 8292481 142334..144325 1 NC_013082.1 similar to uniprot|P09959 Saccharomyces cerevisiae YLR182W SWI6 Transcription cofactor forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition involved in meiotic gene expression localization regulated by phosphorylation potential Cdc28p substrate; KLTH0F01826p 144325 8292481 KLTH0F01826g Lachancea thermotolerans CBS 6340 KLTH0F01826p XP_002554290.1 142334 D 559295 CDS KLTH0F01848g 255716020 8292482 complement(144487..146034) 1 NC_013082.1 similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF; KLTH0F01848p 146034 8292482 KLTH0F01848g Lachancea thermotolerans CBS 6340 KLTH0F01848p XP_002554291.1 144487 R 559295 CDS KLTH0F01892g 255716022 8292484 149177..150085 1 NC_013082.1 similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W; KLTH0F01892p 150085 8292484 KLTH0F01892g Lachancea thermotolerans CBS 6340 KLTH0F01892p XP_002554292.1 149177 D 559295 CDS KLTH0F01914g 255716024 8292485 join(150478..150484,150856..151115) 1 NC_013082.1 highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit; KLTH0F01914p 151115 8292485 KLTH0F01914g Lachancea thermotolerans CBS 6340 KLTH0F01914p XP_002554293.1 150478 D 559295 CDS KLTH0F01936g 255716026 8292486 complement(151241..153382) 1 NC_013082.1 similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways interacts physically with Mec1p putative homolog of S. pombe Rad26 and human ATRIP; KLTH0F01936p 153382 8292486 KLTH0F01936g Lachancea thermotolerans CBS 6340 KLTH0F01936p XP_002554294.1 151241 R 559295 CDS KLTH0F01958g 255716028 8292487 154767..155525 1 NC_013082.1 highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs; KLTH0F01958p 155525 8292487 KLTH0F01958g Lachancea thermotolerans CBS 6340 KLTH0F01958p XP_002554295.1 154767 D 559295 CDS KLTH0F01980g 255716030 8292488 155740..157611 1 NC_013082.1 similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p; KLTH0F01980p 157611 8292488 KLTH0F01980g Lachancea thermotolerans CBS 6340 KLTH0F01980p XP_002554296.1 155740 D 559295 CDS KLTH0F02002g 255716032 8292489 158021..161119 1 NC_013082.1 similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate And to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily- conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; KLTH0F02002p 161119 8292489 KLTH0F02002g Lachancea thermotolerans CBS 6340 KLTH0F02002p XP_002554297.1 158021 D 559295 CDS KLTH0F02024g 255716034 8292490 161423..163627 1 NC_013082.1 similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress; KLTH0F02024p 163627 8292490 KLTH0F02024g Lachancea thermotolerans CBS 6340 KLTH0F02024p XP_002554298.1 161423 D 559295 CDS KLTH0F02046g 255716036 8292491 164010..165473 1 NC_013082.1 similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; KLTH0F02046p 165473 8292491 KLTH0F02046g Lachancea thermotolerans CBS 6340 KLTH0F02046p XP_002554299.1 164010 D 559295 CDS KLTH0F02068g 255716038 8292492 complement(165601..169410) 1 NC_013082.1 similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy; KLTH0F02068p 169410 8292492 KLTH0F02068g Lachancea thermotolerans CBS 6340 KLTH0F02068p XP_002554300.1 165601 R 559295 CDS KLTH0F02090g 255716040 8292493 complement(170047..171369) 1 NC_013082.1 similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain; KLTH0F02090p 171369 8292493 KLTH0F02090g Lachancea thermotolerans CBS 6340 KLTH0F02090p XP_002554301.1 170047 R 559295 CDS KLTH0F02112g 255716042 8292494 join(171589..171793,171847..172328) 1 NC_013082.1 conserved hypothetical protein; KLTH0F02112p 172328 8292494 KLTH0F02112g Lachancea thermotolerans CBS 6340 KLTH0F02112p XP_002554302.1 171589 D 559295 CDS KLTH0F02134g 255716044 8292495 172432..173496 1 NC_013082.1 similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability; KLTH0F02134p 173496 8292495 KLTH0F02134g Lachancea thermotolerans CBS 6340 KLTH0F02134p XP_002554303.1 172432 D 559295 CDS KLTH0F02156g 255716046 8292496 173860..175536 1 NC_013082.1 similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W; KLTH0F02156p 175536 8292496 KLTH0F02156g Lachancea thermotolerans CBS 6340 KLTH0F02156p XP_002554304.1 173860 D 559295 CDS KLTH0F02178g 255716048 8292497 175709..176068 1 NC_013082.1 similar to uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF; KLTH0F02178p 176068 8292497 KLTH0F02178g Lachancea thermotolerans CBS 6340 KLTH0F02178p XP_002554305.1 175709 D 559295 CDS KLTH0F02200g 255716050 8292498 complement(176232..177281) 1 NC_013082.1 similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase; KLTH0F02200p 177281 8292498 KLTH0F02200g Lachancea thermotolerans CBS 6340 KLTH0F02200p XP_002554306.1 176232 R 559295 CDS KLTH0F02222g 255716052 8292499 177818..182149 1 NC_013082.1 similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation; KLTH0F02222p 182149 8292499 KLTH0F02222g Lachancea thermotolerans CBS 6340 KLTH0F02222p XP_002554307.1 177818 D 559295 CDS KLTH0F02244g 255716054 8292500 182354..184459 1 NC_013082.1 similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF; KLTH0F02244p 184459 8292500 KLTH0F02244g Lachancea thermotolerans CBS 6340 KLTH0F02244p XP_002554308.1 182354 D 559295 CDS KLTH0F02266g 255716056 8292501 complement(184716..186182) 1 NC_013082.1 conserved hypothetical protein; KLTH0F02266p 186182 8292501 KLTH0F02266g Lachancea thermotolerans CBS 6340 KLTH0F02266p XP_002554309.1 184716 R 559295 CDS KLTH0F02288g 255716058 8292502 186895..188037 1 NC_013082.1 weakly similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C Hypothetical ORF; KLTH0F02288p 188037 8292502 KLTH0F02288g Lachancea thermotolerans CBS 6340 KLTH0F02288p XP_002554310.1 186895 D 559295 CDS KLTH0F02310g 255716060 8292503 188430..192074 1 NC_013082.1 similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I; KLTH0F02310p 192074 8292503 KLTH0F02310g Lachancea thermotolerans CBS 6340 KLTH0F02310p XP_002554311.1 188430 D 559295 CDS KLTH0F02332g 255716062 8292504 complement(192112..193521) 1 NC_013082.1 similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; KLTH0F02332p 193521 8292504 KLTH0F02332g Lachancea thermotolerans CBS 6340 KLTH0F02332p XP_002554312.1 192112 R 559295 CDS KLTH0F02354g 255716064 8292505 complement(193705..195906) 1 NC_013082.1 similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport; KLTH0F02354p 195906 8292505 KLTH0F02354g Lachancea thermotolerans CBS 6340 KLTH0F02354p XP_002554313.1 193705 R 559295 CDS KLTH0F02376g 255716066 8292506 complement(196194..202124) 1 NC_013082.1 some similarities with uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1; KLTH0F02376p 202124 8292506 KLTH0F02376g Lachancea thermotolerans CBS 6340 KLTH0F02376p XP_002554314.1 196194 R 559295 CDS KLTH0F02398g 255716068 8292507 complement(202746..204413) 1 NC_013082.1 similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance; KLTH0F02398p 204413 8292507 KLTH0F02398g Lachancea thermotolerans CBS 6340 KLTH0F02398p XP_002554315.1 202746 R 559295 CDS KLTH0F02420g 255716070 8292508 205827..207692 1 NC_013082.1 similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease one of three amino acid permeases (Alp1p Can1p Lyp1p) responsible for uptake of cationic amino acids; KLTH0F02420p 207692 8292508 KLTH0F02420g Lachancea thermotolerans CBS 6340 KLTH0F02420p XP_002554316.1 205827 D 559295 CDS KLTH0F02442g 255716072 8292509 208501..211584 1 NC_013082.1 similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5- biphosphate may control cytokineses through the actin cytoskeleton; KLTH0F02442p 211584 8292509 KLTH0F02442g Lachancea thermotolerans CBS 6340 KLTH0F02442p XP_002554317.1 208501 D 559295 CDS KLTH0F02464g 255716074 8292510 212372..213523 1 NC_013082.1 similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p; KLTH0F02464p 213523 8292510 KLTH0F02464g Lachancea thermotolerans CBS 6340 KLTH0F02464p XP_002554318.1 212372 D 559295 CDS KLTH0F02486g 255716076 8292511 complement(213688..214482) 1 NC_013082.1 similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large- scale protein-protein interaction data; KLTH0F02486p 214482 8292511 KLTH0F02486g Lachancea thermotolerans CBS 6340 KLTH0F02486p XP_002554319.1 213688 R 559295 CDS KLTH0F02508g 255716078 8292512 complement(214785..217952) 1 NC_013082.1 similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C; KLTH0F02508p 217952 8292512 KLTH0F02508g Lachancea thermotolerans CBS 6340 KLTH0F02508p XP_002554320.1 214785 R 559295 CDS KLTH0F02530g 255716080 8292513 218224..219279 1 NC_013082.1 similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol; KLTH0F02530p 219279 8292513 KLTH0F02530g Lachancea thermotolerans CBS 6340 KLTH0F02530p XP_002554321.1 218224 D 559295 CDS KLTH0F02552g 255716082 8292514 complement(219375..222959) 1 NC_013082.1 similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF; KLTH0F02552p 222959 8292514 KLTH0F02552g Lachancea thermotolerans CBS 6340 KLTH0F02552p XP_002554322.1 219375 R 559295 CDS KLTH0F02574g 255716084 8292515 complement(223080..224204) 1 NC_013082.1 similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition; KLTH0F02574p 224204 8292515 KLTH0F02574g Lachancea thermotolerans CBS 6340 KLTH0F02574p XP_002554323.1 223080 R 559295 CDS KLTH0F02596g 255716086 8292516 complement(224401..225249) 1 NC_013082.1 weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C; KLTH0F02596p 225249 8292516 KLTH0F02596g Lachancea thermotolerans CBS 6340 KLTH0F02596p XP_002554324.1 224401 R 559295 CDS KLTH0F02618g 255716088 8292517 complement(225395..226483) 1 NC_013082.1 similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C; KLTH0F02618p 226483 8292517 KLTH0F02618g Lachancea thermotolerans CBS 6340 KLTH0F02618p XP_002554325.1 225395 R 559295 CDS KLTH0F02640g 255716090 8292518 226621..233223 1 NC_013082.1 similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair; KLTH0F02640p 233223 8292518 KLTH0F02640g Lachancea thermotolerans CBS 6340 KLTH0F02640p XP_002554326.1 226621 D 559295 CDS KLTH0F02662g 255716092 8292519 233389..234804 1 NC_013082.1 similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; KLTH0F02662p 234804 8292519 KLTH0F02662g Lachancea thermotolerans CBS 6340 KLTH0F02662p XP_002554327.1 233389 D 559295 CDS KLTH0F02684g 255716094 8292520 234959..236029 1 NC_013082.1 weakly similar to uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication; KLTH0F02684p 236029 8292520 KLTH0F02684g Lachancea thermotolerans CBS 6340 KLTH0F02684p XP_002554328.1 234959 D 559295 CDS KLTH0F02706g 255716096 8292521 complement(236068..236556) 1 NC_013082.1 similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability; KLTH0F02706p 236556 8292521 KLTH0F02706g Lachancea thermotolerans CBS 6340 KLTH0F02706p XP_002554329.1 236068 R 559295 CDS KLTH0F02728g 255716098 8292522 complement(236844..237065) 1 NC_013082.1 highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase; KLTH0F02728p 237065 8292522 KLTH0F02728g Lachancea thermotolerans CBS 6340 KLTH0F02728p XP_002554330.1 236844 R 559295 CDS KLTH0F02750g 255716100 8292523 complement(237265..239487) 1 NC_013082.1 similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)-localized peripheral membrane protein required for Golgi-to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat; KLTH0F02750p 239487 8292523 KLTH0F02750g Lachancea thermotolerans CBS 6340 KLTH0F02750p XP_002554331.1 237265 R 559295 CDS KLTH0F02794g 255716102 8293302 complement(240488..244186) 1 NC_013082.1 similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C- terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF; KLTH0F02794p 244186 8293302 KLTH0F02794g Lachancea thermotolerans CBS 6340 KLTH0F02794p XP_002554332.1 240488 R 559295 CDS KLTH0F02816g 255716104 8292525 complement(244375..245595) 1 NC_013082.1 similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase; KLTH0F02816p 245595 8292525 KLTH0F02816g Lachancea thermotolerans CBS 6340 KLTH0F02816p XP_002554333.1 244375 R 559295 CDS KLTH0F02838g 255716106 8292526 complement(245748..246740) 1 NC_013082.1 conserved hypothetical protein; KLTH0F02838p 246740 8292526 KLTH0F02838g Lachancea thermotolerans CBS 6340 KLTH0F02838p XP_002554334.1 245748 R 559295 CDS KLTH0F02860g 255716108 8292527 complement(246868..248406) 1 NC_013082.1 similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane; KLTH0F02860p 248406 8292527 KLTH0F02860g Lachancea thermotolerans CBS 6340 KLTH0F02860p XP_002554335.1 246868 R 559295 CDS KLTH0F02882g 255716110 8292528 248890..251325 1 NC_013082.1 similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities; KLTH0F02882p 251325 8292528 KLTH0F02882g Lachancea thermotolerans CBS 6340 KLTH0F02882p XP_002554336.1 248890 D 559295 CDS KLTH0F02904g 255716112 8292529 complement(251463..251951) 1 NC_013082.1 highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C; KLTH0F02904p 251951 8292529 KLTH0F02904g Lachancea thermotolerans CBS 6340 KLTH0F02904p XP_002554337.1 251463 R 559295 CDS KLTH0F02926g 255716114 8292530 complement(252354..253478) 1 NC_013082.1 some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF; KLTH0F02926p 253478 8292530 KLTH0F02926g Lachancea thermotolerans CBS 6340 KLTH0F02926p XP_002554338.1 252354 R 559295 CDS KLTH0F02948g 255716116 8292531 254134..255333 1 NC_013082.1 weakly similar to uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component; KLTH0F02948p 255333 8292531 KLTH0F02948g Lachancea thermotolerans CBS 6340 KLTH0F02948p XP_002554339.1 254134 D 559295 CDS KLTH0F02970g 255716118 8292532 complement(255421..256305) 1 NC_013082.1 similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit; KLTH0F02970p 256305 8292532 KLTH0F02970g Lachancea thermotolerans CBS 6340 KLTH0F02970p XP_002554340.1 255421 R 559295 CDS KLTH0F02992g 255716120 8292533 complement(256926..258650) 1 NC_013082.1 similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C- terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs; KLTH0F02992p 258650 8292533 KLTH0F02992g Lachancea thermotolerans CBS 6340 KLTH0F02992p XP_002554341.1 256926 R 559295 CDS KLTH0F03014g 255716122 8292534 260568..262406 1 NC_013082.1 similar to uniprot|P53749 Saccharomyces cerevisiae YNR063W Hypothetical ORF; KLTH0F03014p 262406 8292534 KLTH0F03014g Lachancea thermotolerans CBS 6340 KLTH0F03014p XP_002554342.1 260568 D 559295 CDS KLTH0F03036g 255716124 8292535 join(262704..262823,262877..264139) 1 NC_013082.1 similar to uniprot|P53748 Saccharomyces cerevisiae YNR062C Hypothetical ORF; KLTH0F03036p 264139 8292535 KLTH0F03036g Lachancea thermotolerans CBS 6340 KLTH0F03036p XP_002554343.1 262704 D 559295 CDS KLTH0F03058g 255716126 8292536 264710..268606 1 NC_013082.1 similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining; KLTH0F03058p 268606 8292536 KLTH0F03058g Lachancea thermotolerans CBS 6340 KLTH0F03058p XP_002554344.1 264710 D 559295 CDS KLTH0F03080g 255716128 8292537 complement(268621..270222) 1 NC_013082.1 similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43; KLTH0F03080p 270222 8292537 KLTH0F03080g Lachancea thermotolerans CBS 6340 KLTH0F03080p XP_002554345.1 268621 R 559295 CDS KLTH0F03102g 255716130 8292538 complement(270371..271609) 1 NC_013082.1 highly similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49; KLTH0F03102p 271609 8292538 KLTH0F03102g Lachancea thermotolerans CBS 6340 KLTH0F03102p XP_002554346.1 270371 R 559295 CDS KLTH0F03124g 255716132 8292539 271947..272435 1 NC_013082.1 similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain; KLTH0F03124p 272435 8292539 KLTH0F03124g Lachancea thermotolerans CBS 6340 KLTH0F03124p XP_002554347.1 271947 D 559295 CDS KLTH0F03146g 255716134 8292540 complement(272447..274261) 1 NC_013082.1 similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF; KLTH0F03146p 274261 8292540 KLTH0F03146g Lachancea thermotolerans CBS 6340 KLTH0F03146p XP_002554348.1 272447 R 559295 CDS KLTH0F03168g 255716136 8292541 274654..276975 1 NC_013082.1 similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability; KLTH0F03168p 276975 8292541 KLTH0F03168g Lachancea thermotolerans CBS 6340 KLTH0F03168p XP_002554349.1 274654 D 559295 CDS KLTH0F03190g 255716138 8292542 join(277312..277328,277394..278195) 1 NC_013082.1 similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75; KLTH0F03190p 278195 8292542 KLTH0F03190g Lachancea thermotolerans CBS 6340 KLTH0F03190p XP_002554350.1 277312 D 559295 CDS KLTH0F03212g 255716140 8292543 complement(278216..278830) 1 NC_013082.1 similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C; KLTH0F03212p 278830 8292543 KLTH0F03212g Lachancea thermotolerans CBS 6340 KLTH0F03212p XP_002554351.1 278216 R 559295 CDS KLTH0F03234g 255716142 8292544 complement(279196..279522) 1 NC_013082.1 highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1; KLTH0F03234p 279522 8292544 KLTH0F03234g Lachancea thermotolerans CBS 6340 KLTH0F03234p XP_002554352.1 279196 R 559295 CDS KLTH0F03256g 255716144 8292545 280245..282368 1 NC_013082.1 some similarities with uniprot|P33338 Saccharomyces cerevisiae YNL243W SLA2 Transmembrane actin- binding protein involved in membrane cytoskeleton assembly and cell polarization adaptor protein that links actin to clathrin and endocytosis present in the actin cortical patch of the emerging bud tip dimer in vivo; KLTH0F03256p 282368 8292545 KLTH0F03256g Lachancea thermotolerans CBS 6340 KLTH0F03256p XP_002554353.1 280245 D 559295 CDS KLTH0F03278g 255716146 8292546 283035..283712 1 NC_013082.1 conserved hypothetical protein; KLTH0F03278p 283712 8292546 KLTH0F03278g Lachancea thermotolerans CBS 6340 KLTH0F03278p XP_002554354.1 283035 D 559295 CDS KLTH0F03300g 255716148 8292547 complement(283918..285474) 1 NC_013082.1 conserved hypothetical protein; KLTH0F03300p 285474 8292547 KLTH0F03300g Lachancea thermotolerans CBS 6340 KLTH0F03300p XP_002554355.1 283918 R 559295 CDS KLTH0F03322g 255716150 8292548 286122..286886 1 NC_013082.1 weakly similar to uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin peroxisomal membrane protein with a C-terminal zinc-binding RING domain forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import; KLTH0F03322p 286886 8292548 KLTH0F03322g Lachancea thermotolerans CBS 6340 KLTH0F03322p XP_002554356.1 286122 D 559295 CDS KLTH0F03344g 255716152 8292549 287064..289019 1 NC_013082.1 weakly similar to uniprot|P07252 Saccharomyces cerevisiae YJL209W CBP1 Protein required for COB mRNA stability or 5' processing required for translation of COB mRNAs; KLTH0F03344p 289019 8292549 KLTH0F03344g Lachancea thermotolerans CBS 6340 KLTH0F03344p XP_002554357.1 287064 D 559295 CDS KLTH0F03366g 255716154 8292550 complement(289075..290079) 1 NC_013082.1 similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease has RNAse and DNA endo- and exonucleolytic activities has a role in mitochondrial recombination; KLTH0F03366p 290079 8292550 KLTH0F03366g Lachancea thermotolerans CBS 6340 KLTH0F03366p XP_002554358.1 289075 R 559295 CDS KLTH0F03388g 255716156 8292551 complement(290517..296435) 1 NC_013082.1 similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF; KLTH0F03388p 296435 8292551 KLTH0F03388g Lachancea thermotolerans CBS 6340 KLTH0F03388p XP_002554359.1 290517 R 559295 CDS KLTH0F03432g 255716158 8292552 300417..300815 1 NC_013082.1 conserved hypothetical protein; KLTH0F03432p 300815 8292552 KLTH0F03432g Lachancea thermotolerans CBS 6340 KLTH0F03432p XP_002554360.1 300417 D 559295 CDS KLTH0F03454g 255716160 8292553 301123..302166 1 NC_013082.1 conserved hypothetical protein; KLTH0F03454p 302166 8292553 KLTH0F03454g Lachancea thermotolerans CBS 6340 KLTH0F03454p XP_002554361.1 301123 D 559295 CDS KLTH0F03476g 255716162 8292554 complement(302182..304512) 1 NC_013082.1 similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1; KLTH0F03476p 304512 8292554 KLTH0F03476g Lachancea thermotolerans CBS 6340 KLTH0F03476p XP_002554362.1 302182 R 559295 CDS KLTH0F03498g 255716164 8292555 304634..305827 1 NC_013082.1 similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex required for spliceosome assembly; KLTH0F03498p 305827 8292555 KLTH0F03498g Lachancea thermotolerans CBS 6340 KLTH0F03498p XP_002554363.1 304634 D 559295 CDS KLTH0F03542g 255716166 8292557 306546..308315 1 NC_013082.1 similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p; KLTH0F03542p 308315 8292557 KLTH0F03542g Lachancea thermotolerans CBS 6340 KLTH0F03542p XP_002554364.1 306546 D 559295 CDS KLTH0F03564g 255716168 8292558 309896..314143 1 NC_013082.1 weakly similar to uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types; KLTH0F03564p 314143 8292558 KLTH0F03564g Lachancea thermotolerans CBS 6340 KLTH0F03564p XP_002554365.1 309896 D 559295 CDS KLTH0F03586g 255716170 8292559 complement(314283..316646) 1 NC_013082.1 highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF; KLTH0F03586p 316646 8292559 KLTH0F03586g Lachancea thermotolerans CBS 6340 KLTH0F03586p XP_002554366.1 314283 R 559295 CDS KLTH0F03630g 255716172 8292561 complement(317294..317590) 1 NC_013082.1 no similarity; KLTH0F03630p 317590 8292561 KLTH0F03630g Lachancea thermotolerans CBS 6340 KLTH0F03630p XP_002554367.1 317294 R 559295 CDS KLTH0F03652g 255716174 8292562 318194..320905 1 NC_013082.1 similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C PHO87 Low-affinity inorganic phosphate (Pi) transporter involved in activation of PHO pathway expression is independent of Pi concentration and Pho4p activity contains 12 membrane-spanning segments and uniprot|P39535 Saccharomyces cerevisiae YJL198W PHO90; KLTH0F03652p 320905 8292562 KLTH0F03652g Lachancea thermotolerans CBS 6340 KLTH0F03652p XP_002554368.1 318194 D 559295 CDS KLTH0F03674g 255716176 8292563 321662..325258 1 NC_013082.1 similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins; KLTH0F03674p 325258 8292563 KLTH0F03674g Lachancea thermotolerans CBS 6340 KLTH0F03674p XP_002554369.1 321662 D 559295 CDS KLTH0F03696g 255716178 8292564 complement(325326..326318) 1 NC_013082.1 similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase; KLTH0F03696p 326318 8292564 KLTH0F03696g Lachancea thermotolerans CBS 6340 KLTH0F03696p XP_002554370.1 325326 R 559295 CDS KLTH0F03718g 255716180 8292565 326533..327672 1 NC_013082.1 similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing; KLTH0F03718p 327672 8292565 KLTH0F03718g Lachancea thermotolerans CBS 6340 KLTH0F03718p XP_002554371.1 326533 D 559295 CDS KLTH0F03740g 255716182 8292566 complement(327788..328816) 1 NC_013082.1 similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3- beta- glucan synthase vacuolar ATPase and the secretory pathway; KLTH0F03740p 328816 8292566 KLTH0F03740g Lachancea thermotolerans CBS 6340 KLTH0F03740p XP_002554372.1 327788 R 559295 CDS KLTH0F03762g 255716184 8292567 complement(329069..332716) 1 NC_013082.1 some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1; KLTH0F03762p 332716 8292567 KLTH0F03762g Lachancea thermotolerans CBS 6340 KLTH0F03762p XP_002554373.1 329069 R 559295 CDS KLTH0F03784g 255716186 8292568 335081..336580 1 NC_013082.1 similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre- replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2- 7p DNA association homologous to S. pombe Cdc18p; KLTH0F03784p 336580 8292568 KLTH0F03784g Lachancea thermotolerans CBS 6340 KLTH0F03784p XP_002554374.1 335081 D 559295 CDS KLTH0F03806g 255716188 8292569 complement(336740..343105) 1 NC_013082.1 similar to uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1; KLTH0F03806p 343105 8292569 KLTH0F03806g Lachancea thermotolerans CBS 6340 KLTH0F03806p XP_002554375.1 336740 R 559295 CDS KLTH0F03828g 255716190 8292570 complement(343452..344264) 1 NC_013082.1 similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7; KLTH0F03828p 344264 8292570 KLTH0F03828g Lachancea thermotolerans CBS 6340 KLTH0F03828p XP_002554376.1 343452 R 559295 CDS KLTH0F03850g 255716192 8292571 join(344707..344713,345336..345742) 1 NC_013082.1 highly similar to uniprot|P06367 Saccharomyces cerevisiae YCR031C RPS14A ribosomal protein 59 (rp59) of the small (40S) ribosomal subunit; KLTH0F03850p 345742 8292571 KLTH0F03850g Lachancea thermotolerans CBS 6340 KLTH0F03850p XP_002554377.1 344707 D 559295 CDS KLTH0F03872g 255716194 8292572 complement(346042..346434) 1 NC_013082.1 highly similar to uniprot|Q3E7Y3 Saccharomyces cerevisiae YLR367W RPS22B and highly simila to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit; KLTH0F03872p 346434 8292572 KLTH0F03872g Lachancea thermotolerans CBS 6340 KLTH0F03872p XP_002554378.1 346042 R 559295 CDS KLTH0F03916g 255716196 8293300 complement(348177..350282) 1 NC_013082.1 some similarities with uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate; KLTH0F03916p 350282 8293300 KLTH0F03916g Lachancea thermotolerans CBS 6340 KLTH0F03916p XP_002554379.1 348177 R 559295 CDS KLTH0F03938g 255716198 8292574 351536..353224 1 NC_013082.1 similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; KLTH0F03938p 353224 8292574 KLTH0F03938g Lachancea thermotolerans CBS 6340 KLTH0F03938p XP_002554380.1 351536 D 559295 CDS KLTH0F03982g 255716200 8292576 355886..356347 1 NC_013082.1 no similarity; KLTH0F03982p 356347 8292576 KLTH0F03982g Lachancea thermotolerans CBS 6340 KLTH0F03982p XP_002554381.1 355886 D 559295 CDS KLTH0F04004g 255716202 8292577 357095..357349 1 NC_013082.1 no similarity; KLTH0F04004p 357349 8292577 KLTH0F04004g Lachancea thermotolerans CBS 6340 KLTH0F04004p XP_002554382.1 357095 D 559295 CDS KLTH0F04026g 255716204 8292578 357616..358641 1 NC_013082.1 similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 NADPH-dependent methylglyoxal reductase; KLTH0F04026p 358641 8292578 KLTH0F04026g Lachancea thermotolerans CBS 6340 KLTH0F04026p XP_002554383.1 357616 D 559295 CDS KLTH0F04048g 255716206 8292579 359492..361243 1 NC_013082.1 weakly similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease; KLTH0F04048p 361243 8292579 KLTH0F04048g Lachancea thermotolerans CBS 6340 KLTH0F04048p XP_002554384.1 359492 D 559295 CDS KLTH0F04070g 255716208 8292580 363875..365299 1 NC_013082.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; KLTH0F04070p 365299 8292580 KLTH0F04070g Lachancea thermotolerans CBS 6340 KLTH0F04070p XP_002554385.1 363875 D 559295 CDS KLTH0F04092g 255716210 8292581 366691..369255 1 NC_013082.1 similar to uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein with a potential role in actin cytoskeletal organization overexpression suppresses a pfy1 (profilin) null mutation; KLTH0F04092p 369255 8292581 KLTH0F04092g Lachancea thermotolerans CBS 6340 KLTH0F04092p XP_002554386.1 366691 D 559295 CDS KLTH0F04114g 255716212 8292582 complement(369389..370267) 1 NC_013082.1 weakly similar to uniprot|P46983 Saccharomyces cerevisiae YJL185C Hypothetical ORF; KLTH0F04114p 370267 8292582 KLTH0F04114g Lachancea thermotolerans CBS 6340 KLTH0F04114p XP_002554387.1 369389 R 559295 CDS KLTH0F04136g 255716214 8292583 join(370788..371026,371090..371225) 1 NC_013082.1 similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance Single- stranded zinc finger DNA-binding protein; KLTH0F04136p 371225 8292583 KLTH0F04136g Lachancea thermotolerans CBS 6340 KLTH0F04136p XP_002554388.1 370788 D 559295 CDS KLTH0F04158g 255716216 8292584 371760..372158 1 NC_013082.1 similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Protein of unknown function proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides also proposed to be involved in responding to osmotic stress; KLTH0F04158p 372158 8292584 KLTH0F04158g Lachancea thermotolerans CBS 6340 KLTH0F04158p XP_002554389.1 371760 D 559295 CDS KLTH0F04180g 255716218 8292585 372429..373916 1 NC_013082.1 similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph; KLTH0F04180p 373916 8292585 KLTH0F04180g Lachancea thermotolerans CBS 6340 KLTH0F04180p XP_002554390.1 372429 D 559295 CDS KLTH0F04202g 255716220 8292586 374123..375367 1 NC_013082.1 similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p Mnn9p Mnn10p and Hoc1p and mediates elongation of the polysaccharide mannan backbone has homology to Mnn10p; KLTH0F04202p 375367 8292586 KLTH0F04202g Lachancea thermotolerans CBS 6340 KLTH0F04202p XP_002554391.1 374123 D 559295 CDS KLTH0F04246g 255716222 8292587 complement(378401..379354) 1 NC_013082.1 similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; KLTH0F04246p 379354 8292587 KLTH0F04246g Lachancea thermotolerans CBS 6340 KLTH0F04246p XP_002554392.1 378401 R 559295 CDS KLTH0F04268g 255716224 8292588 379441..379851 1 NC_013082.1 highly similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin; KLTH0F04268p 379851 8292588 KLTH0F04268g Lachancea thermotolerans CBS 6340 KLTH0F04268p XP_002554393.1 379441 D 559295 CDS KLTH0F04290g 255716226 8292589 complement(379953..380819) 1 NC_013082.1 weakly similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type II membrane protein that binds phosphatidylinositol 3-phosphate required for the cytoplasm-to-vacuole targeting (Cvt) pathway; KLTH0F04290p 380819 8292589 KLTH0F04290g Lachancea thermotolerans CBS 6340 KLTH0F04290p XP_002554394.1 379953 R 559295 CDS KLTH0F04312g 255716228 8292590 join(382022..382330,382421..382666) 1 NC_013082.1 highly similar to uniprot|P46990 Saccharomyces cerevisiae YJL177W; KLTH0F04312p 382666 8292590 KLTH0F04312g Lachancea thermotolerans CBS 6340 KLTH0F04312p XP_002554395.1 382022 D 559295 CDS KLTH0F04334g 255716230 8292591 complement(382773..384677) 1 NC_013082.1 similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C; KLTH0F04334p 384677 8292591 KLTH0F04334g Lachancea thermotolerans CBS 6340 KLTH0F04334p XP_002554396.1 382773 R 559295 CDS KLTH0F04356g 255716232 8292592 complement(384963..387518) 1 NC_013082.1 some similarities with uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 transcription factor; KLTH0F04356p 387518 8292592 KLTH0F04356g Lachancea thermotolerans CBS 6340 KLTH0F04356p XP_002554397.1 384963 R 559295 CDS KLTH0F04378g 255716234 8292593 388891..389817 1 NC_013082.1 similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects; KLTH0F04378p 389817 8292593 KLTH0F04378g Lachancea thermotolerans CBS 6340 KLTH0F04378p XP_002554398.1 388891 D 559295 CDS KLTH0F04400g 255716236 8292594 complement(389870..390220) 1 NC_013082.1 similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; KLTH0F04400p 390220 8292594 KLTH0F04400g Lachancea thermotolerans CBS 6340 KLTH0F04400p XP_002554399.1 389870 R 559295 CDS KLTH0F04422g 255716238 8292595 390590..392308 1 NC_013082.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; KLTH0F04422p 392308 8292595 KLTH0F04422g Lachancea thermotolerans CBS 6340 KLTH0F04422p XP_002554400.1 390590 D 559295 CDS KLTH0F04444g 255716240 8292596 complement(393714..395123) 1 NC_013082.1 similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Cell surface a factor receptor transcribed in alpha cells and required for mating by alpha cells couples to MAP kinase cascade to mediate pheromone response ligand bound receptors undergo endocytosis and recycling to the plasma membrane; KLTH0F04444p 395123 8292596 KLTH0F04444g Lachancea thermotolerans CBS 6340 KLTH0F04444p XP_002554401.1 393714 R 559295 CDS KLTH0F04466g 255716242 8292597 complement(395584..396768) 1 NC_013082.1 similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C Hypothetical ORF; KLTH0F04466p 396768 8292597 KLTH0F04466g Lachancea thermotolerans CBS 6340 KLTH0F04466p XP_002554402.1 395584 R 559295 CDS KLTH0F04488g 255716244 8292598 complement(397034..397621) 1 NC_013082.1 weakly similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha- factor; KLTH0F04488p 397621 8292598 KLTH0F04488g Lachancea thermotolerans CBS 6340 KLTH0F04488p XP_002554403.1 397034 R 559295 CDS KLTH0F04510g 255716246 8292599 complement(398063..400123) 1 NC_013082.1 similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation methylates a lysine residue of histone H3 associates with the C-terminal domain of Rpo21p histone methylation activity is regulated by phosphorylation status of Rpo21p; KLTH0F04510p 400123 8292599 KLTH0F04510g Lachancea thermotolerans CBS 6340 KLTH0F04510p XP_002554404.1 398063 R 559295 CDS KLTH0F04532g 255716248 8292600 complement(400336..402342) 1 NC_013082.1 weakly similar to uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface; KLTH0F04532p 402342 8292600 KLTH0F04532g Lachancea thermotolerans CBS 6340 KLTH0F04532p XP_002554405.1 400336 R 559295 CDS KLTH0F04554g 255716250 8292601 403607..404902 1 NC_013082.1 similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter transports zinc from storage in the vacuole to the cytoplasm when needed transcription is induced under conditions of zinc deficiency; KLTH0F04554p 404902 8292601 KLTH0F04554g Lachancea thermotolerans CBS 6340 KLTH0F04554p XP_002554406.1 403607 D 559295 CDS KLTH0F04576g 255716252 8292602 complement(404994..406643) 1 NC_013082.1 similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine putative polyamine transporter in the Golgi or post-Golgi vesicles; KLTH0F04576p 406643 8292602 KLTH0F04576g Lachancea thermotolerans CBS 6340 KLTH0F04576p XP_002554407.1 404994 R 559295 CDS KLTH0F04598g 255716254 8292603 join(406984..407006,407069..409862) 1 NC_013082.1 similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 involved in splicing U5 snRNP- specific protein related to EF-2; KLTH0F04598p 409862 8292603 KLTH0F04598g Lachancea thermotolerans CBS 6340 KLTH0F04598p XP_002554408.1 406984 D 559295 CDS KLTH0F04620g 255716256 8292604 410119..411339 1 NC_013082.1 highly similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly localizes to the nucleolus; KLTH0F04620p 411339 8292604 KLTH0F04620g Lachancea thermotolerans CBS 6340 KLTH0F04620p XP_002554409.1 410119 D 559295 CDS KLTH0F04642g 255716258 8292605 411628..412683 1 NC_013082.1 highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167W ERG20 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis; KLTH0F04642p 412683 8292605 KLTH0F04642g Lachancea thermotolerans CBS 6340 KLTH0F04642p XP_002554410.1 411628 D 559295 CDS KLTH0F04664g 255716260 8292606 412976..413260 1 NC_013082.1 highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Ubiquinol cytochrome-c reductase subunit 8; KLTH0F04664p 413260 8292606 KLTH0F04664g Lachancea thermotolerans CBS 6340 KLTH0F04664p XP_002554411.1 412976 D 559295 CDS KLTH0F04686g 255716262 8292607 413669..416209 1 NC_013082.1 weakly similar to uniprot|P36003 Saccharomyces cerevisiae YKL171W Hypothetical ORF; KLTH0F04686p 416209 8292607 KLTH0F04686g Lachancea thermotolerans CBS 6340 KLTH0F04686p XP_002554412.1 413669 D 559295 CDS KLTH0F04708g 255716264 8292608 416514..416930 1 NC_013082.1 highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; KLTH0F04708p 416930 8292608 KLTH0F04708g Lachancea thermotolerans CBS 6340 KLTH0F04708p XP_002554413.1 416514 D 559295 CDS KLTH0F04730g 255716266 8292609 complement(417013..419133) 1 NC_013082.1 some similarities with uniprot|P38970 Saccharomyces cerevisiae YJL165C HAL5 Putative protein kinase overexpression increases sodium and lithium tolerance whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake suggesting a role in regulation of Trk1p and/or Trk2p transporters; KLTH0F04730p 419133 8292609 KLTH0F04730g Lachancea thermotolerans CBS 6340 KLTH0F04730p XP_002554414.1 417013 R 559295 CDS KLTH0F04752g 255716268 8292610 complement(419404..421263) 1 NC_013082.1 conserved hypothetical protein; KLTH0F04752p 421263 8292610 KLTH0F04752g Lachancea thermotolerans CBS 6340 KLTH0F04752p XP_002554415.1 419404 R 559295 CDS KLTH0F04774g 255716270 8292611 complement(421673..422068) 1 NC_013082.1 similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation; KLTH0F04774p 422068 8292611 KLTH0F04774g Lachancea thermotolerans CBS 6340 KLTH0F04774p XP_002554416.1 421673 R 559295 CDS KLTH0F04796g 255716272 8292612 complement(423222..424898) 1 NC_013082.1 similar to gnl|GLV|DEHA0E00440g Debaryomyces hansenii DEHA0E00440g; KLTH0F04796p 424898 8292612 KLTH0F04796g Lachancea thermotolerans CBS 6340 KLTH0F04796p XP_002554417.1 423222 R 559295 CDS KLTH0F04818g 255716274 8292613 complement(425861..426169) 1 NC_013082.1 no similarity; KLTH0F04818p 426169 8292613 KLTH0F04818g Lachancea thermotolerans CBS 6340 KLTH0F04818p XP_002554418.1 425861 R 559295 CDS KLTH0F04840g 255716276 8292614 complement(427194..428339) 1 NC_013082.1 highly similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 and highly similar to uniprot|P06244 Saccharomyces cerevisiae YJL164C TPK1; KLTH0F04840p 428339 8292614 KLTH0F04840g Lachancea thermotolerans CBS 6340 KLTH0F04840p XP_002554419.1 427194 R 559295 CDS KLTH0F04862g 255716278 8292615 complement(428886..430730) 1 NC_013082.1 similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C Hypothetical ORF; KLTH0F04862p 430730 8292615 KLTH0F04862g Lachancea thermotolerans CBS 6340 KLTH0F04862p XP_002554420.1 428886 R 559295 CDS KLTH0F04884g 255716280 8292616 complement(431251..434019) 1 NC_013082.1 highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes; KLTH0F04884p 434019 8292616 KLTH0F04884g Lachancea thermotolerans CBS 6340 KLTH0F04884p XP_002554421.1 431251 R 559295 CDS KLTH0F04906g 255716282 8292617 complement(434195..435967) 1 NC_013082.1 weakly similar to uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; KLTH0F04906p 435967 8292617 KLTH0F04906g Lachancea thermotolerans CBS 6340 KLTH0F04906p XP_002554422.1 434195 R 559295 CDS KLTH0F04972g 255716284 8292620 437256..437774 1 NC_013082.1 similar to uniprot|P46998 Saccharomyces cerevisiae YJL161W FMP33 The authentic non-tagged protein was localized to the mitochondria; KLTH0F04972p 437774 8292620 KLTH0F04972g Lachancea thermotolerans CBS 6340 KLTH0F04972p XP_002554423.1 437256 D 559295 CDS KLTH0F04994g 255716286 8292621 complement(438107..439237) 1 NC_013082.1 similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats; KLTH0F04994p 439237 8292621 KLTH0F04994g Lachancea thermotolerans CBS 6340 KLTH0F04994p XP_002554424.1 438107 R 559295 CDS KLTH0F05016g 255716288 8292622 440672..441877 1 NC_013082.1 similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats; KLTH0F05016p 441877 8292622 KLTH0F05016g Lachancea thermotolerans CBS 6340 KLTH0F05016p XP_002554425.1 440672 D 559295 CDS KLTH0F05060g 255716290 8292624 complement(442756..443496) 1 NC_013082.1 similar to uniprot|P47001 Saccharomyces cerevisiae YJL158C CIS3 cik1 suppressor Protein with homology to Hsp150p and Pir1p Pir2p and Pir3p; KLTH0F05060p 443496 8292624 KLTH0F05060g Lachancea thermotolerans CBS 6340 KLTH0F05060p XP_002554426.1 442756 R 559295 CDS KLTH0F05082g 255716292 8292625 complement(444440..447688) 1 NC_013082.1 weakly similar to uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate; KLTH0F05082p 447688 8292625 KLTH0F05082g Lachancea thermotolerans CBS 6340 KLTH0F05082p XP_002554427.1 444440 R 559295 CDS KLTH0F05104g 255716294 8292626 complement(448219..450258) 1 NC_013082.1 similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; KLTH0F05104p 450258 8292626 KLTH0F05104g Lachancea thermotolerans CBS 6340 KLTH0F05104p XP_002554428.1 448219 R 559295 CDS KLTH0F05126g 255716296 8292627 complement(450521..451813) 1 NC_013082.1 highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism; KLTH0F05126p 451813 8292627 KLTH0F05126g Lachancea thermotolerans CBS 6340 KLTH0F05126p XP_002554429.1 450521 R 559295 CDS KLTH0F05148g 255716298 8292628 complement(452835..455408) 1 NC_013082.1 similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component; KLTH0F05148p 455408 8292628 KLTH0F05148g Lachancea thermotolerans CBS 6340 KLTH0F05148p XP_002554430.1 452835 R 559295 CDS KLTH0F05170g 255716300 8292629 456433..457476 1 NC_013082.1 similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress; KLTH0F05170p 457476 8292629 KLTH0F05170g Lachancea thermotolerans CBS 6340 KLTH0F05170p XP_002554431.1 456433 D 559295 CDS KLTH0F05192g 255716302 8292630 458025..458612 1 NC_013082.1 similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C FMP18 The authentic non-tagged protein was localized to the mitochondria; KLTH0F05192p 458612 8292630 KLTH0F05192g Lachancea thermotolerans CBS 6340 KLTH0F05192p XP_002554432.1 458025 D 559295 CDS KLTH0F05214g 255716304 8292631 complement(458955..459335) 1 NC_013082.1 similar to uniprot|P14359 Saccharomyces cerevisiae YJL151C SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein- vacuolar targeting; KLTH0F05214p 459335 8292631 KLTH0F05214g Lachancea thermotolerans CBS 6340 KLTH0F05214p XP_002554433.1 458955 R 559295 CDS KLTH0F05236g 255716306 8292632 460572..462356 1 NC_013082.1 similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W; KLTH0F05236p 462356 8292632 KLTH0F05236g Lachancea thermotolerans CBS 6340 KLTH0F05236p XP_002554434.1 460572 D 559295 CDS KLTH0F05258g 255716308 8292633 complement(462417..464825) 1 NC_013082.1 weakly similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W Hypothetical ORF; KLTH0F05258p 464825 8292633 KLTH0F05258g Lachancea thermotolerans CBS 6340 KLTH0F05258p XP_002554435.1 462417 R 559295 CDS KLTH0F05280g 255716310 8292634 464952..466367 1 NC_013082.1 weakly similar to uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability; KLTH0F05280p 466367 8292634 KLTH0F05280g Lachancea thermotolerans CBS 6340 KLTH0F05280p XP_002554436.1 464952 D 559295 CDS KLTH0F05346g 255716312 8293295 467382..467897 1 NC_013082.1 weakly similar to uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5; KLTH0F05346p 467897 8293295 KLTH0F05346g Lachancea thermotolerans CBS 6340 KLTH0F05346p XP_002554437.1 467382 D 559295 CDS KLTH0F05368g 255716314 8292636 complement(468018..468833) 1 NC_013082.1 some similarities with uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit involved in RNA polymerase II transcription initiation; KLTH0F05368p 468833 8292636 KLTH0F05368g Lachancea thermotolerans CBS 6340 KLTH0F05368p XP_002554438.1 468018 R 559295 CDS KLTH0F05390g 255716316 8292637 complement(469335..470432) 1 NC_013082.1 weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C Hypothetical ORF; KLTH0F05390p 470432 8292637 KLTH0F05390g Lachancea thermotolerans CBS 6340 KLTH0F05390p XP_002554439.1 469335 R 559295 CDS KLTH0F05412g 255716318 8292638 470606..471733 1 NC_013082.1 weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis appears to act indirectly to promote Ime2p-mediated late meiotic functions found in growing cells and degraded during sporulation; KLTH0F05412p 471733 8292638 KLTH0F05412g Lachancea thermotolerans CBS 6340 KLTH0F05412p XP_002554440.1 470606 D 559295 CDS KLTH0F05434g 255716320 8292639 472035..472892 1 NC_013082.1 similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 putative phosphatidylinositol transfer protein; KLTH0F05434p 472892 8292639 KLTH0F05434g Lachancea thermotolerans CBS 6340 KLTH0F05434p XP_002554441.1 472035 D 559295 CDS KLTH0F05456g 255716322 8292640 complement(474006..475148) 1 NC_013082.1 highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase catalyzes the conversion of dethiobiotin to biotin which is the last step of the biotin biosynthesis pathway complements E. coli bioB mutant; KLTH0F05456p 475148 8292640 KLTH0F05456g Lachancea thermotolerans CBS 6340 KLTH0F05456p XP_002554442.1 474006 R 559295 CDS KLTH0F05478g 255716324 8292641 475684..476040 1 NC_013082.1 conserved hypothetical protein; KLTH0F05478p 476040 8292641 KLTH0F05478g Lachancea thermotolerans CBS 6340 KLTH0F05478p XP_002554443.1 475684 D 559295 CDS KLTH0F05500g 255716326 8292642 476328..476804 1 NC_013082.1 highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Mitochondrial inner membrane protein involved in protein import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins; KLTH0F05500p 476804 8292642 KLTH0F05500g Lachancea thermotolerans CBS 6340 KLTH0F05500p XP_002554444.1 476328 D 559295 CDS KLTH0F05522g 255716328 8292643 complement(477035..478975) 1 NC_013082.1 similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal; KLTH0F05522p 478975 8292643 KLTH0F05522g Lachancea thermotolerans CBS 6340 KLTH0F05522p XP_002554445.1 477035 R 559295 CDS KLTH0F05544g 255716330 8292644 479908..480501 1 NC_013082.1 similar to uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32 forms two subunit dissociable complex with Rpb7p dispensable under some environmental conditions involved in export of mRNA to cytoplasm under stress conditions; KLTH0F05544p 480501 8292644 KLTH0F05544g Lachancea thermotolerans CBS 6340 KLTH0F05544p XP_002554446.1 479908 D 559295 CDS KLTH0F05566g 255716332 8292645 complement(480552..481823) 1 NC_013082.1 similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N- linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; KLTH0F05566p 481823 8292645 KLTH0F05566g Lachancea thermotolerans CBS 6340 KLTH0F05566p XP_002554447.1 480552 R 559295 CDS KLTH0F05588g 255716334 8292646 complement(482054..482866) 1 NC_013082.1 similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; KLTH0F05588p 482866 8292646 KLTH0F05588g Lachancea thermotolerans CBS 6340 KLTH0F05588p XP_002554448.1 482054 R 559295 CDS KLTH0F05610g 255716336 8292647 complement(483243..484433) 1 NC_013082.1 highly similar to uniprot|P10081 Saccharomyces cerevisiae YKR059W TIF1 and highly similar to uniprot|P10081 Saccharomyces cerevisiae YJL138C TIF2translation initiation factor eIF4A; KLTH0F05610p 484433 8292647 KLTH0F05610g Lachancea thermotolerans CBS 6340 KLTH0F05610p XP_002554449.1 483243 R 559295 CDS KLTH0F05632g 255716338 8292648 complement(484673..486163) 1 NC_013082.1 weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C; KLTH0F05632p 486163 8292648 KLTH0F05632g Lachancea thermotolerans CBS 6340 KLTH0F05632p XP_002554450.1 484673 R 559295 CDS KLTH0F05654g 255716340 8292649 complement(join(486339..486578,486943..486966)) 1 NC_013082.1 highly similar to uniprot|P05760 Saccharomyces cerevisiae YJL136C RPS21B and highly similar to uniprot|P05760 Saccharomyces cerevisiae YKR057W RPS21A, Protein components of the small (40S) ribosomal subunit; KLTH0F05654p 486966 8292649 KLTH0F05654g Lachancea thermotolerans CBS 6340 KLTH0F05654p XP_002554451.1 486339 R 559295 CDS KLTH0F05676g 255716342 8292650 complement(487620..489413) 1 NC_013082.1 similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase 5- methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation previously thought to be an endo-exonuclease; KLTH0F05676p 489413 8292650 KLTH0F05676g Lachancea thermotolerans CBS 6340 KLTH0F05676p XP_002554452.1 487620 R 559295 CDS KLTH0F05698g 255716344 8292651 complement(489561..490376) 1 NC_013082.1 similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely to be involved in the establishment of cell polarity; KLTH0F05698p 490376 8292651 KLTH0F05698g Lachancea thermotolerans CBS 6340 KLTH0F05698p XP_002554453.1 489561 R 559295 CDS KLTH0F05720g 255716346 8292652 490598..502924 1 NC_013082.1 similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein microtubule motor protein required for anaphase spindle elongation involved in spindle assembly chromosome movement and spindle orientation during cell division targeted to microtubule tips by Pac1p; KLTH0F05720p 502924 8292652 KLTH0F05720g Lachancea thermotolerans CBS 6340 KLTH0F05720p XP_002554454.1 490598 D 559295 CDS KLTH0F05742g 255716348 8292653 503094..504317 1 NC_013082.1 similar to uniprot|P47013 Saccharomyces cerevisiae YJL134W LCB3 Long-chain base-1-phosphate phosphatase regulates ceramide and long-chain base phosphates levels involved in incorporation of exogenous long chain bases in sphingolipids; KLTH0F05742p 504317 8292653 KLTH0F05742g Lachancea thermotolerans CBS 6340 KLTH0F05742p XP_002554455.1 503094 D 559295 CDS KLTH0F05764g 255716350 8292654 complement(504717..504995) 1 NC_013082.1 some similarities with uniprot|Q3E7A3 Saccharomyces cerevisiae YJL133C-A; KLTH0F05764p 504995 8292654 KLTH0F05764g Lachancea thermotolerans CBS 6340 KLTH0F05764p XP_002554456.1 504717 R 559295 CDS KLTH0F05786g 255716352 8292655 506028..506951 1 NC_013082.1 highly similar to uniprot|P23500 Saccharomyces cerevisiae YKR052C Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low- iron conditions; may transport other cations in addition to iron; KLTH0F05786p 506951 8292655 KLTH0F05786g Lachancea thermotolerans CBS 6340 KLTH0F05786p XP_002554457.1 506028 D 559295 CDS KLTH0F05808g 255716354 8292656 complement(509026..510267) 1 NC_013082.1 similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Hypothetical ORF; KLTH0F05808p 510267 8292656 KLTH0F05808g Lachancea thermotolerans CBS 6340 KLTH0F05808p XP_002554458.1 509026 R 559295 CDS KLTH0F05830g 255716356 8292657 510405..512597 1 NC_013082.1 similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Hypothetical ORF; KLTH0F05830p 512597 8292657 KLTH0F05830g Lachancea thermotolerans CBS 6340 KLTH0F05830p XP_002554459.1 510405 D 559295 CDS KLTH0F05852g 255716358 8292658 complement(512684..513820) 1 NC_013082.1 similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C Hypothetical ORF; KLTH0F05852p 513820 8292658 KLTH0F05852g Lachancea thermotolerans CBS 6340 KLTH0F05852p XP_002554460.1 512684 R 559295 CDS KLTH0F05874g 255716360 8292659 complement(514124..520786) 1 NC_013082.1 highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase; KLTH0F05874p 520786 8292659 KLTH0F05874g Lachancea thermotolerans CBS 6340 KLTH0F05874p XP_002554461.1 514124 R 559295 CDS KLTH0F05896g 255716362 8292660 complement(521903..525343) 1 NC_013082.1 similar to uniprot|P12685 Saccharomyces cerevisiae YJL129C TRK1 Component of the Trk1p-Trk2p potassium transport system 180 kDa high affinity potassium transporter; KLTH0F05896p 525343 8292660 KLTH0F05896g Lachancea thermotolerans CBS 6340 KLTH0F05896p XP_002554462.1 521903 R 559295 CDS KLTH0F05918g 255716364 8292661 complement(525566..527254) 1 NC_013082.1 some similarities with uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase that plays a pivotal role in the osmosensing signal- transduction pathway activated under severe osmotic stress; KLTH0F05918p 527254 8292661 KLTH0F05918g Lachancea thermotolerans CBS 6340 KLTH0F05918p XP_002554463.1 525566 R 559295 CDS KLTH0F05940g 255716366 8292662 529968..531923 1 NC_013082.1 conserved hypothetical protein; KLTH0F05940p 531923 8292662 KLTH0F05940g Lachancea thermotolerans CBS 6340 KLTH0F05940p XP_002554464.1 529968 D 559295 CDS KLTH0F05962g 255716368 8292663 complement(531962..533626) 1 NC_013082.1 similar to uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase required for transcriptional regulation at core promoters functions at or near the TATA box; KLTH0F05962p 533626 8292663 KLTH0F05962g Lachancea thermotolerans CBS 6340 KLTH0F05962p XP_002554465.1 531962 R 559295 CDS KLTH0F05984g 255716370 8292664 533877..534935 1 NC_013082.1 similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W; KLTH0F05984p 534935 8292664 KLTH0F05984g Lachancea thermotolerans CBS 6340 KLTH0F05984p XP_002554466.1 533877 D 559295 CDS KLTH0F06006g 255716372 8292665 complement(534961..536163) 1 NC_013082.1 highly similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1- methyladenosine) methyltransferase with Gcd10p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression; KLTH0F06006p 536163 8292665 KLTH0F06006g Lachancea thermotolerans CBS 6340 KLTH0F06006p XP_002554467.1 534961 R 559295 CDS KLTH0F06028g 255716374 8292666 complement(537096..537578) 1 NC_013082.1 similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay; KLTH0F06028p 537578 8292666 KLTH0F06028g Lachancea thermotolerans CBS 6340 KLTH0F06028p XP_002554468.1 537096 R 559295 CDS KLTH0F06050g 255716376 8292667 538194..538580 1 NC_013082.1 similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 The authentic non-tagged protein was localized to the mitochondria; KLTH0F06050p 538580 8292667 KLTH0F06050g Lachancea thermotolerans CBS 6340 KLTH0F06050p XP_002554469.1 538194 D 559295 CDS KLTH0F06072g 255716378 8292668 complement(538668..540104) 1 NC_013082.1 similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C Hypothetical ORF; KLTH0F06072p 540104 8292668 KLTH0F06072g Lachancea thermotolerans CBS 6340 KLTH0F06072p XP_002554470.1 538668 R 559295 CDS KLTH0F06094g 255716380 8292669 540625..541110 1 NC_013082.1 similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W Hypothetical ORF; KLTH0F06094p 541110 8292669 KLTH0F06094g Lachancea thermotolerans CBS 6340 KLTH0F06094p XP_002554471.1 540625 D 559295 CDS KLTH0F06116g 255716382 8292670 complement(541186..541896) 1 NC_013082.1 highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-Phosphate 3- epimerase; KLTH0F06116p 541896 8292670 KLTH0F06116g Lachancea thermotolerans CBS 6340 KLTH0F06116p XP_002554472.1 541186 R 559295 CDS KLTH0F06160g 255716384 8292672 542483..543781 1 NC_013082.1 similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p required for the regulation of microtubule dynamics during mitosis controls bud morphogenesis involved in the transport of H2A and H2B histones to the nucleus; KLTH0F06160p 543781 8292672 KLTH0F06160g Lachancea thermotolerans CBS 6340 KLTH0F06160p XP_002554473.1 542483 D 559295 CDS KLTH0F06182g 255716386 8292673 544018..544980 1 NC_013082.1 similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange; KLTH0F06182p 544980 8292673 KLTH0F06182g Lachancea thermotolerans CBS 6340 KLTH0F06182p XP_002554474.1 544018 D 559295 CDS KLTH0F06204g 255716388 8292674 complement(545288..545989) 1 NC_013082.1 similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF; KLTH0F06204p 545989 8292674 KLTH0F06204g Lachancea thermotolerans CBS 6340 KLTH0F06204p XP_002554475.1 545288 R 559295 CDS KLTH0F06226g 255716390 8292675 join(546103..546136,546192..546733) 1 NC_013082.1 weakly similar to uniprot|P36138 Saccharomyces cerevisiae YKR045C Hypothetical ORF; KLTH0F06226p 546733 8292675 KLTH0F06226g Lachancea thermotolerans CBS 6340 KLTH0F06226p XP_002554476.1 546103 D 559295 CDS KLTH0F06248g 255716392 8292676 547112..548017 1 NC_013082.1 similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane transcription and localization are regulated by phosphate levels; KLTH0F06248p 548017 8292676 KLTH0F06248g Lachancea thermotolerans CBS 6340 KLTH0F06248p XP_002554477.1 547112 D 559295 CDS KLTH0F06270g 255716394 8292677 complement(548173..549417) 1 NC_013082.1 similar to uniprot|P36137 Saccharomyces cerevisiae YKR044W UIP5 Protein of unknown function; KLTH0F06270p 549417 8292677 KLTH0F06270g Lachancea thermotolerans CBS 6340 KLTH0F06270p XP_002554478.1 548173 R 559295 CDS KLTH0F06314g 255716396 8292679 550148..550963 1 NC_013082.1 highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Hypothetical ORF; KLTH0F06314p 550963 8292679 KLTH0F06314g Lachancea thermotolerans CBS 6340 KLTH0F06314p XP_002554479.1 550148 D 559295 CDS KLTH0F06336g 255716398 8292680 551107..552114 1 NC_013082.1 conserved hypothetical protein; KLTH0F06336p 552114 8292680 KLTH0F06336g Lachancea thermotolerans CBS 6340 KLTH0F06336p XP_002554480.1 551107 D 559295 CDS KLTH0F06358g 255716400 8292681 complement(552396..553481) 1 NC_013082.1 some similarities with uniprot|P36135 Saccharomyces cerevisiae YKR042W UTH1 Youth involved in determining yeast longevity involved in cell growth; KLTH0F06358p 553481 8292681 KLTH0F06358g Lachancea thermotolerans CBS 6340 KLTH0F06358p XP_002554481.1 552396 R 559295 CDS KLTH0F06380g 255716402 8292684 554948..556126 1 NC_013082.1 conserved hypothetical protein; KLTH0F06380p 556126 8292684 KLTH0F06380g Lachancea thermotolerans CBS 6340 KLTH0F06380p XP_002554482.1 554948 D 559295 CDS KLTH0F06424g 255716404 8292683 556413..557303 1 NC_013082.1 some similarities with uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor involved in chromatin assembly after DNA replication anti- silencing protein that causes derepression of silent loci when overexpressed; KLTH0F06424p 557303 8292683 KLTH0F06424g Lachancea thermotolerans CBS 6340 KLTH0F06424p XP_002554483.1 556413 D 559295 CDS KLTH0F06446g 255716406 8292685 complement(557340..558164) 1 NC_013082.1 similar to uniprot|P36134 Saccharomyces cerevisiae YKR041W Hypothetical ORF; KLTH0F06446p 558164 8292685 KLTH0F06446g Lachancea thermotolerans CBS 6340 KLTH0F06446p XP_002554484.1 557340 R 559295 CDS KLTH0F06468g 255716408 8292686 559256..561769 1 NC_013082.1 similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p; KLTH0F06468p 561769 8292686 KLTH0F06468g Lachancea thermotolerans CBS 6340 KLTH0F06468p XP_002554485.1 559256 D 559295 CDS KLTH0F06490g 255716410 8292687 complement(join(561947..563100,563192..563213)) 1 NC_013082.1 highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity; KLTH0F06490p 563213 8292687 KLTH0F06490g Lachancea thermotolerans CBS 6340 KLTH0F06490p XP_002554486.1 561947 R 559295 CDS KLTH0F06512g 255716412 8292688 complement(563724..564836) 1 NC_013082.1 weakly similar to uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF; KLTH0F06512p 564836 8292688 KLTH0F06512g Lachancea thermotolerans CBS 6340 KLTH0F06512p XP_002554487.1 563724 R 559295 CDS KLTH0F06534g 255716414 8292689 complement(565211..566611) 1 NC_013082.1 similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit; KLTH0F06534p 566611 8292689 KLTH0F06534g Lachancea thermotolerans CBS 6340 KLTH0F06534p XP_002554488.1 565211 R 559295 CDS KLTH0F06556g 255716416 8292690 566940..568337 1 NC_013082.1 similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes; KLTH0F06556p 568337 8292690 KLTH0F06556g Lachancea thermotolerans CBS 6340 KLTH0F06556p XP_002554489.1 566940 D 559295 CDS KLTH0F06578g 255716418 8292691 complement(568519..570309) 1 NC_013082.1 similar to uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p; KLTH0F06578p 570309 8292691 KLTH0F06578g Lachancea thermotolerans CBS 6340 KLTH0F06578p XP_002554490.1 568519 R 559295 CDS KLTH0F06600g 255716420 8292692 complement(570612..572798) 1 NC_013082.1 similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C; KLTH0F06600p 572798 8292692 KLTH0F06600g Lachancea thermotolerans CBS 6340 KLTH0F06600p XP_002554491.1 570612 R 559295 CDS KLTH0F06622g 255716422 8292693 573968..575260 1 NC_013082.1 KLTH0F06622p 575260 8292693 KLTH0F06622g Lachancea thermotolerans CBS 6340 KLTH0F06622p XP_002554492.1 573968 D 559295 CDS KLTH0F06644g 255716424 8292694 578425..579681 1 NC_013082.1 highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate; KLTH0F06644p 579681 8292694 KLTH0F06644g Lachancea thermotolerans CBS 6340 KLTH0F06644p XP_002554493.1 578425 D 559295 CDS KLTH0F06666g 255716426 8292695 579926..582085 1 NC_013082.1 similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF; KLTH0F06666p 582085 8292695 KLTH0F06666g Lachancea thermotolerans CBS 6340 KLTH0F06666p XP_002554494.1 579926 D 559295 CDS KLTH0F06688g 255716428 8292696 583833..584738 1 NC_013082.1 similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 and to YDL021W uniprot|Q12008 Saccharomyces cerevisiae YDL021W GPM2, Homologs of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; KLTH0F06688p 584738 8292696 KLTH0F06688g Lachancea thermotolerans CBS 6340 KLTH0F06688p XP_002554495.1 583833 D 559295 CDS KLTH0F06710g 255716430 8292697 complement(585209..586648) 1 NC_013082.1 some similarities with uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses; KLTH0F06710p 586648 8292697 KLTH0F06710g Lachancea thermotolerans CBS 6340 KLTH0F06710p XP_002554496.1 585209 R 559295 CDS KLTH0F06732g 255716432 8292698 complement(586960..588672) 1 NC_013082.1 similar to uniprot|Q6B2F0 Saccharomyces cerevisiae YOL055C THI20 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI21 and THI22 functionally redundant with Thi21p; KLTH0F06732p 588672 8292698 KLTH0F06732g Lachancea thermotolerans CBS 6340 KLTH0F06732p XP_002554497.1 586960 R 559295 CDS KLTH0F06754g 255716434 8292699 590569..592872 1 NC_013082.1 weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466.; KLTH0F06754p 592872 8292699 KLTH0F06754g Lachancea thermotolerans CBS 6340 KLTH0F06754p XP_002554498.1 590569 D 559295 CDS KLTH0F06776g 255716436 8292700 594001..595953 1 NC_013082.1 similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1- Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation; KLTH0F06776p 595953 8292700 KLTH0F06776g Lachancea thermotolerans CBS 6340 KLTH0F06776p XP_002554499.1 594001 D 559295 CDS KLTH0F06798g 255716438 8292701 complement(596017..596943) 1 NC_013082.1 similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability; KLTH0F06798p 596943 8292701 KLTH0F06798g Lachancea thermotolerans CBS 6340 KLTH0F06798p XP_002554500.1 596017 R 559295 CDS KLTH0F06820g 255716440 8292702 complement(597192..598775) 1 NC_013082.1 highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D- erythroascorbic acid which is protective against oxidative stress; KLTH0F06820p 598775 8292702 KLTH0F06820g Lachancea thermotolerans CBS 6340 KLTH0F06820p XP_002554501.1 597192 R 559295 CDS KLTH0F06842g 255716442 8292703 complement(join(599443..600761,600988..601012)) 1 NC_013082.1 highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta- tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules; KLTH0F06842p 601012 8292703 KLTH0F06842g Lachancea thermotolerans CBS 6340 KLTH0F06842p XP_002554502.1 599443 R 559295 CDS KLTH0F06864g 255716444 8292704 complement(601480..603192) 1 NC_013082.1 similar to uniprot|P25297 YML123C Saccharomyces cerevisiae PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; KLTH0F06864p 603192 8292704 KLTH0F06864g Lachancea thermotolerans CBS 6340 KLTH0F06864p XP_002554503.1 601480 R 559295 CDS KLTH0F06886g 255716446 8292705 complement(604652..605977) 1 NC_013082.1 highly similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase) joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway; KLTH0F06886p 605977 8292705 KLTH0F06886g Lachancea thermotolerans CBS 6340 KLTH0F06886p XP_002554504.1 604652 R 559295 CDS KLTH0F06930g 255716448 8292707 complement(606927..607508) 1 NC_013082.1 weakly similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration; KLTH0F06930p 607508 8292707 KLTH0F06930g Lachancea thermotolerans CBS 6340 KLTH0F06930p XP_002554505.1 606927 R 559295 CDS KLTH0F06952g 255716450 8292708 607612..608511 1 NC_013082.1 highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs; KLTH0F06952p 608511 8292708 KLTH0F06952g Lachancea thermotolerans CBS 6340 KLTH0F06952p XP_002554506.1 607612 D 559295 CDS KLTH0F06974g 255716452 8292709 complement(608833..610383) 1 NC_013082.1 similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae; KLTH0F06974p 610383 8292709 KLTH0F06974g Lachancea thermotolerans CBS 6340 KLTH0F06974p XP_002554507.1 608833 R 559295 CDS KLTH0F06996g 255716454 8292710 612749..614692 1 NC_013082.1 highly similar to uniprot|P12398 Saccharomyces cerevisiae YJR045C; KLTH0F06996p 614692 8292710 KLTH0F06996g Lachancea thermotolerans CBS 6340 KLTH0F06996p XP_002554508.1 612749 D 559295 CDS KLTH0F07018g 255716456 8292711 join(615061..615181,615237..615538) 1 NC_013082.1 highly similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Vacuolar Protein Sorting YJR044c; KLTH0F07018p 615538 8292711 KLTH0F07018g Lachancea thermotolerans CBS 6340 KLTH0F07018p XP_002554509.1 615061 D 559295 CDS KLTH0F07062g 255716458 8292713 616169..617032 1 NC_013082.1 similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)- phosphate contains a FYVE finger domain; KLTH0F07062p 617032 8292713 KLTH0F07062g Lachancea thermotolerans CBS 6340 KLTH0F07062p XP_002554510.1 616169 D 559295 CDS KLTH0F07084g 255716460 8292714 complement(617226..618536) 1 NC_013082.1 similar to uniprot|Q12153 Saccharomyces cerevisiae YDR312W SSF2 high copy suppressor of G beta subunit temperature sensitive mutation possibly involved in mating; KLTH0F07084p 618536 8292714 KLTH0F07084g Lachancea thermotolerans CBS 6340 KLTH0F07084p XP_002554511.1 617226 R 559295 CDS KLTH0F07106g 255716462 8292715 618637..620214 1 NC_013082.1 highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF-4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA; KLTH0F07106p 620214 8292715 KLTH0F07106g Lachancea thermotolerans CBS 6340 KLTH0F07106p XP_002554512.1 618637 D 559295 CDS KLTH0F07128g 255716464 8292716 complement(620327..622192) 1 NC_013082.1 similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators; KLTH0F07128p 622192 8292716 KLTH0F07128g Lachancea thermotolerans CBS 6340 KLTH0F07128p XP_002554513.1 620327 R 559295 CDS KLTH0F07150g 255716466 8292717 624084..625706 1 NC_013082.1 similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein; KLTH0F07150p 625706 8292717 KLTH0F07150g Lachancea thermotolerans CBS 6340 KLTH0F07150p XP_002554514.1 624084 D 559295 CDS KLTH0F07172g 255716468 8292718 625852..626976 1 NC_013082.1 similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE; KLTH0F07172p 626976 8292718 KLTH0F07172g Lachancea thermotolerans CBS 6340 KLTH0F07172p XP_002554515.1 625852 D 559295 CDS KLTH0F07194g 255716470 8292719 627776..630565 1 NC_013082.1 some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppresor of mar1-1 (sir2) mutation nuclear protein involved in silencing; KLTH0F07194p 630565 8292719 KLTH0F07194g Lachancea thermotolerans CBS 6340 KLTH0F07194p XP_002554516.1 627776 D 559295 CDS KLTH0F07216g 255716472 8292720 631218..632099 1 NC_013082.1 similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; KLTH0F07216p 632099 8292720 KLTH0F07216g Lachancea thermotolerans CBS 6340 KLTH0F07216p XP_002554517.1 631218 D 559295 CDS KLTH0F07238g 255716474 8292721 632361..633017 1 NC_013082.1 conserved hypothetical protein; KLTH0F07238p 633017 8292721 KLTH0F07238g Lachancea thermotolerans CBS 6340 KLTH0F07238p XP_002554518.1 632361 D 559295 CDS KLTH0F07260g 255716476 8292722 633250..634383 1 NC_013082.1 weakly similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac- interactive binding (CRIB) domain; KLTH0F07260p 634383 8292722 KLTH0F07260g Lachancea thermotolerans CBS 6340 KLTH0F07260p XP_002554519.1 633250 D 559295 CDS KLTH0F07282g 255716478 8292723 complement(634594..635130) 1 NC_013082.1 similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex; KLTH0F07282p 635130 8292723 KLTH0F07282g Lachancea thermotolerans CBS 6340 KLTH0F07282p XP_002554520.1 634594 R 559295 CDS KLTH0F07304g 255716480 8292724 635266..635712 1 NC_013082.1 similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component; KLTH0F07304p 635712 8292724 KLTH0F07304g Lachancea thermotolerans CBS 6340 KLTH0F07304p XP_002554521.1 635266 D 559295 CDS KLTH0F07326g 255716482 8292725 complement(635723..637696) 1 NC_013082.1 weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF; KLTH0F07326p 637696 8292725 KLTH0F07326g Lachancea thermotolerans CBS 6340 KLTH0F07326p XP_002554522.1 635723 R 559295 CDS KLTH0F07348g 255716484 8292726 638030..639790 1 NC_013082.1 conserved hypothetical protein; KLTH0F07348p 639790 8292726 KLTH0F07348g Lachancea thermotolerans CBS 6340 KLTH0F07348p XP_002554523.1 638030 D 559295 CDS KLTH0F07392g 255716486 8292728 640519..641829 1 NC_013082.1 similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF; KLTH0F07392p 641829 8292728 KLTH0F07392g Lachancea thermotolerans CBS 6340 KLTH0F07392p XP_002554524.1 640519 D 559295 CDS KLTH0F07414g 255716488 8292729 join(641893..641946,642031..642525) 1 NC_013082.1 similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C; KLTH0F07414p 642525 8292729 KLTH0F07414g Lachancea thermotolerans CBS 6340 KLTH0F07414p XP_002554525.1 641893 D 559295 CDS KLTH0F07436g 255716490 8292730 complement(642567..642953) 1 NC_013082.1 similar to uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin; KLTH0F07436p 642953 8292730 KLTH0F07436g Lachancea thermotolerans CBS 6340 KLTH0F07436p XP_002554526.1 642567 R 559295 CDS KLTH0F07458g 255716492 8292731 643237..644073 1 NC_013082.1 some similarities with uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor; KLTH0F07458p 644073 8292731 KLTH0F07458g Lachancea thermotolerans CBS 6340 KLTH0F07458p XP_002554527.1 643237 D 559295 CDS KLTH0F07480g 255716494 8292732 complement(644172..648410) 1 NC_013082.1 weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding potential Cdc28p substrate; KLTH0F07480p 648410 8292732 KLTH0F07480g Lachancea thermotolerans CBS 6340 KLTH0F07480p XP_002554528.1 644172 R 559295 CDS KLTH0F07524g 255716496 8292734 649475..652861 1 NC_013082.1 similar to uniprot|P47135 Saccharomyces cerevisiae YJR091C JSN1 Member of the Puf family of RNA- binding proteins and to uniprot|Q12221 Saccharomyces cerevisiae YPR042C PUF2 mRNA binding protein; KLTH0F07524p 652861 8292734 KLTH0F07524g Lachancea thermotolerans CBS 6340 KLTH0F07524p XP_002554529.1 649475 D 559295 CDS KLTH0F07546g 255716498 8292735 653440..656745 1 NC_013082.1 similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin- ligase complex required for Cln1p and Cln2p degradation involved in carbon catabolite repression glucose-dependent divalent cation transport high-affinity glucose transport and morphogenesis; KLTH0F07546p 656745 8292735 KLTH0F07546g Lachancea thermotolerans CBS 6340 KLTH0F07546p XP_002554530.1 653440 D 559295 CDS KLTH0F07568g 255716500 8292736 complement(656807..659383) 1 NC_013082.1 weakly similar to uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Protein involved in cell cycle regulation and chromosome segregation contains BIR (Baculovirus Inhibitor of apoptosis Repeat) domain; KLTH0F07568p 659383 8292736 KLTH0F07568g Lachancea thermotolerans CBS 6340 KLTH0F07568p XP_002554531.1 656807 R 559295 CDS KLTH0F07590g 255716502 8292737 complement(659645..660844) 1 NC_013082.1 highly similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 eIF5 mediates hydrolysis of eIF2- GTP (SUI2 SUI3 GCD11) at start codons Translation initiation factor eIF-5; KLTH0F07590p 660844 8292737 KLTH0F07590g Lachancea thermotolerans CBS 6340 KLTH0F07590p XP_002554532.1 659645 R 559295 CDS KLTH0F07612g 255716504 8292738 661580..662434 1 NC_013082.1 similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C Hypothetical ORF; KLTH0F07612p 662434 8292738 KLTH0F07612g Lachancea thermotolerans CBS 6340 KLTH0F07612p XP_002554533.1 661580 D 559295 CDS KLTH0F07634g 255716506 8292739 complement(662501..663529) 1 NC_013082.1 similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein involved in regulation of the TOR pathway; KLTH0F07634p 663529 8292739 KLTH0F07634g Lachancea thermotolerans CBS 6340 KLTH0F07634p XP_002554534.1 662501 R 559295 CDS KLTH0F07656g 255716508 8292740 663648..664253 1 NC_013082.1 similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen involved in disulfide bond formation within the ER; KLTH0F07656p 664253 8292740 KLTH0F07656g Lachancea thermotolerans CBS 6340 KLTH0F07656p XP_002554535.1 663648 D 559295 CDS KLTH0F07678g 255716510 8292741 complement(664276..664560) 1 NC_013082.1 similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit forms a dimer with Ste4p to activate the mating signaling pathway forms a heterotrimer with Gpa1p and Ste4p to dampen signaling C- terminus is palmitoylated and farnesylated which are required for normal signaling; KLTH0F07678p 664560 8292741 KLTH0F07678g Lachancea thermotolerans CBS 6340 KLTH0F07678p XP_002554536.1 664276 R 559295 CDS KLTH0F07700g 255716512 8292742 665501..665818 1 NC_013082.1 highly similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Hypothetical ORF; KLTH0F07700p 665818 8292742 KLTH0F07700g Lachancea thermotolerans CBS 6340 KLTH0F07700p XP_002554537.1 665501 D 559295 CDS KLTH0F07722g 255716514 8292743 complement(666717..668060) 1 NC_013082.1 similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W CSN12 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin- like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling; KLTH0F07722p 668060 8292743 KLTH0F07722g Lachancea thermotolerans CBS 6340 KLTH0F07722p XP_002554538.1 666717 R 559295 CDS KLTH0F07744g 255716516 8292744 668134..668955 1 NC_013082.1 weakly similar to uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization potential Cdc28p substrate; KLTH0F07744p 668955 8292744 KLTH0F07744g Lachancea thermotolerans CBS 6340 KLTH0F07744p XP_002554539.1 668134 D 559295 CDS KLTH0F07766g 255716518 8292745 complement(669046..670443) 1 NC_013082.1 similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 vacuolar ATPase V1 domain subunit H (54 kDa); KLTH0F07766p 670443 8292745 KLTH0F07766g Lachancea thermotolerans CBS 6340 KLTH0F07766p XP_002554540.1 669046 R 559295 CDS KLTH0F07788g 255716520 8292746 complement(671629..672738) 1 NC_013082.1 highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS) synthesizes glutamine from glutamate and ammonia with Glt1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation; KLTH0F07788p 672738 8292746 KLTH0F07788g Lachancea thermotolerans CBS 6340 KLTH0F07788p XP_002554541.1 671629 R 559295 CDS KLTH0F07810g 255716522 8292747 674329..676026 1 NC_013082.1 weakly similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF; KLTH0F07810p 676026 8292747 KLTH0F07810g Lachancea thermotolerans CBS 6340 KLTH0F07810p XP_002554542.1 674329 D 559295 CDS KLTH0F07832g 255716524 8292748 complement(676464..677492) 1 NC_013082.1 similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase; KLTH0F07832p 677492 8292748 KLTH0F07832g Lachancea thermotolerans CBS 6340 KLTH0F07832p XP_002554543.1 676464 R 559295 CDS KLTH0F07854g 255716526 8292749 complement(677647..680013) 1 NC_013082.1 some similarities with uniprot|Q12151 Saccharomyces cerevisiae YDR213W UPC2 involved in sterol uptake zinc finger transcription factor of the Zn(2)- Cys(6) binuclear cluster domain type; KLTH0F07854p 680013 8292749 KLTH0F07854g Lachancea thermotolerans CBS 6340 KLTH0F07854p XP_002554544.1 677647 R 559295 CDS KLTH0F07876g 255716528 8292750 complement(680690..682369) 1 NC_013082.1 highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 tailless complex polypeptide 1 chaperonin subunit alpha; KLTH0F07876p 682369 8292750 KLTH0F07876g Lachancea thermotolerans CBS 6340 KLTH0F07876p XP_002554545.1 680690 R 559295 CDS KLTH0F07898g 255716530 8292751 complement(684569..685396) 1 NC_013082.1 similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Hypothetical ORF; KLTH0F07898p 685396 8292751 KLTH0F07898g Lachancea thermotolerans CBS 6340 KLTH0F07898p XP_002554546.1 684569 R 559295 CDS KLTH0F07920g 255716532 8292752 complement(687410..687985) 1 NC_013082.1 highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins; KLTH0F07920p 687985 8292752 KLTH0F07920g Lachancea thermotolerans CBS 6340 KLTH0F07920p XP_002554547.1 687410 R 559295 CDS KLTH0F07942g 255716534 8292753 complement(688360..690540) 1 NC_013082.1 similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; KLTH0F07942p 690540 8292753 KLTH0F07942g Lachancea thermotolerans CBS 6340 KLTH0F07942p XP_002554548.1 688360 R 559295 CDS KLTH0F07986g 255716536 8292755 complement(691369..691605) 1 NC_013082.1 similar to uniprot|Q03482 Saccharomyces cerevisiae YDR210W hypothetical protein; KLTH0F07986p 691605 8292755 KLTH0F07986g Lachancea thermotolerans CBS 6340 KLTH0F07986p XP_002554549.1 691369 R 559295 CDS KLTH0F08008g 255716538 8292756 complement(691998..694016) 1 NC_013082.1 some similarities with uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol- 4-phosphate 5-kinase involved in actin cytoskeleton organization and cell morphogenesis multicopy suppressor of stt4 mutation; KLTH0F08008p 694016 8292756 KLTH0F08008g Lachancea thermotolerans CBS 6340 KLTH0F08008p XP_002554550.1 691998 R 559295 CDS KLTH0F08030g 255716540 8292757 695704..698982 1 NC_013082.1 similar to uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump involved in Na efflux to allow salt tolerance likely not involved in Li efflux; KLTH0F08030p 698982 8292757 KLTH0F08030g Lachancea thermotolerans CBS 6340 KLTH0F08030p XP_002554551.1 695704 D 559295 CDS KLTH0F08052g 255716542 8292758 complement(699044..700432) 1 NC_013082.1 similar to uniprot|Q05979 Saccharomyces cerevisiae YLR231C BNA5 Kynureninase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; KLTH0F08052p 700432 8292758 KLTH0F08052g Lachancea thermotolerans CBS 6340 KLTH0F08052p XP_002554552.1 699044 R 559295 CDS KLTH0F08074g 255716544 8292759 701778..703685 1 NC_013082.1 some similarities with uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis- specific transcription Ume6p is a C6 zinc finger URS1- binding protein.; KLTH0F08074p 703685 8292759 KLTH0F08074g Lachancea thermotolerans CBS 6340 KLTH0F08074p XP_002554553.1 701778 D 559295 CDS KLTH0F08096g 255716546 8292760 complement(703918..706308) 1 NC_013082.1 weakly similar to uniprot|Q03466 Saccharomyces cerevisiae YDR206W; KLTH0F08096p 706308 8292760 KLTH0F08096g Lachancea thermotolerans CBS 6340 KLTH0F08096p XP_002554554.1 703918 R 559295 CDS KLTH0F08118g 255716548 8292761 706631..708514 1 NC_013082.1 similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III; KLTH0F08118p 708514 8292761 KLTH0F08118g Lachancea thermotolerans CBS 6340 KLTH0F08118p XP_002554555.1 706631 D 559295 CDS KLTH0F08140g 255716550 8292762 complement(708569..710836) 1 NC_013082.1 weakly similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family localizes to the endoplasmic reticulum and nucleus mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids; KLTH0F08140p 710836 8292762 KLTH0F08140g Lachancea thermotolerans CBS 6340 KLTH0F08140p XP_002554556.1 708569 R 559295 CDS KLTH0F08162g 255716552 8292763 711372..713132 1 NC_013082.1 similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine; KLTH0F08162p 713132 8292763 KLTH0F08162g Lachancea thermotolerans CBS 6340 KLTH0F08162p XP_002554557.1 711372 D 559295 CDS KLTH0F08184g 255716554 8292764 complement(713580..714563) 1 NC_013082.1 similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis possibly functioning in stabilization of Coq7p located on the matrix face of the mitochondrial inner membrane; KLTH0F08184p 714563 8292764 KLTH0F08184g Lachancea thermotolerans CBS 6340 KLTH0F08184p XP_002554558.1 713580 R 559295 CDS KLTH0F08206g 255716556 8292765 714649..715665 1 NC_013082.1 similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p Rav2p Skp1p) a complex that associates with the V1 domain of the vacuolar membrane (H )-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; KLTH0F08206p 715665 8292765 KLTH0F08206g Lachancea thermotolerans CBS 6340 KLTH0F08206p XP_002554559.1 714649 D 559295 CDS KLTH0F08228g 255716558 8292766 complement(715667..716140) 1 NC_013082.1 similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle; KLTH0F08228p 716140 8292766 KLTH0F08228g Lachancea thermotolerans CBS 6340 KLTH0F08228p XP_002554560.1 715667 R 559295 CDS KLTH0F08250g 255716560 8292767 716337..717635 1 NC_013082.1 similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C VPS64; KLTH0F08250p 717635 8292767 KLTH0F08250g Lachancea thermotolerans CBS 6340 KLTH0F08250p XP_002554561.1 716337 D 559295 CDS KLTH0F08272g 255716562 8292768 complement(717660..718631) 1 NC_013082.1 similar to uniprot|Q06005 Saccharomyces cerevisiae YLR239C LIP2 Lipoyl ligase involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups; KLTH0F08272p 718631 8292768 KLTH0F08272g Lachancea thermotolerans CBS 6340 KLTH0F08272p XP_002554562.1 717660 R 559295 CDS KLTH0F08294g 255716564 8292769 718731..720125 1 NC_013082.1 similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C Hypothetical ORF; KLTH0F08294p 720125 8292769 KLTH0F08294g Lachancea thermotolerans CBS 6340 KLTH0F08294p XP_002554563.1 718731 D 559295 CDS KLTH0F08316g 255716566 8292770 complement(720142..721236) 1 NC_013082.1 similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Translational activator of COB mRNA soluble protein cytochrome b translational activator; KLTH0F08316p 721236 8292770 KLTH0F08316g Lachancea thermotolerans CBS 6340 KLTH0F08316p XP_002554564.1 720142 R 559295 CDS KLTH0F08338g 255716568 8292771 721404..722114 1 NC_013082.1 similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C predicted to catalyze the final step in synthesis of Coenzyme A; KLTH0F08338p 722114 8292771 KLTH0F08338g Lachancea thermotolerans CBS 6340 KLTH0F08338p XP_002554565.1 721404 D 559295 CDS KLTH0F08360g 255716570 8292772 complement(722163..723695) 1 NC_013082.1 some similarities with uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation also involved in snoRNA maturation; KLTH0F08360p 723695 8292772 KLTH0F08360g Lachancea thermotolerans CBS 6340 KLTH0F08360p XP_002554566.1 722163 R 559295 CDS KLTH0F08382g 255716572 8292773 724794..726767 1 NC_013082.1 similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns presumed RNA helicase due to DEAD-box motif; KLTH0F08382p 726767 8292773 KLTH0F08382g Lachancea thermotolerans CBS 6340 KLTH0F08382p XP_002554567.1 724794 D 559295 CDS KLTH0F08404g 255716574 8292774 727026..729629 1 NC_013082.1 similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3- phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase; KLTH0F08404p 729629 8292774 KLTH0F08404g Lachancea thermotolerans CBS 6340 KLTH0F08404p XP_002554568.1 727026 D 559295 CDS KLTH0F08426g 255716576 8292775 730037..732391 1 NC_013082.1 similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Hypothetical ORF; KLTH0F08426p 732391 8292775 KLTH0F08426g Lachancea thermotolerans CBS 6340 KLTH0F08426p XP_002554569.1 730037 D 559295 CDS KLTH0F08448g 255716578 8292776 complement(732406..733281) 1 NC_013082.1 similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C; KLTH0F08448p 733281 8292776 KLTH0F08448g Lachancea thermotolerans CBS 6340 KLTH0F08448p XP_002554570.1 732406 R 559295 CDS KLTH0F08470g 255716580 8292777 733431..735029 1 NC_013082.1 weakly similar to uniprot|P49686 Saccharomyces cerevisiae YDR192C NUP42 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p; KLTH0F08470p 735029 8292777 KLTH0F08470g Lachancea thermotolerans CBS 6340 KLTH0F08470p XP_002554571.1 733431 D 559295 CDS KLTH0F08492g 255716582 8292778 735358..736173 1 NC_013082.1 highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Protein required for cell viability; KLTH0F08492p 736173 8292778 KLTH0F08492g Lachancea thermotolerans CBS 6340 KLTH0F08492p XP_002554572.1 735358 D 559295 CDS KLTH0F08514g 255716584 8292779 complement(736218..737393) 1 NC_013082.1 similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst3p in silencing at telomeres cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism; KLTH0F08514p 737393 8292779 KLTH0F08514g Lachancea thermotolerans CBS 6340 KLTH0F08514p XP_002554573.1 736218 R 559295 CDS KLTH0F08536g 255716586 8292780 739646..741025 1 NC_013082.1 highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 RUVB-like protein TIP49a Homologue; KLTH0F08536p 741025 8292780 KLTH0F08536g Lachancea thermotolerans CBS 6340 KLTH0F08536p XP_002554574.1 739646 D 559295 CDS KLTH0F08558g 255716588 8292781 complement(join(741154..743048,743110..743152)) 1 NC_013082.1 similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane- protein complex; KLTH0F08558p 743152 8292781 KLTH0F08558g Lachancea thermotolerans CBS 6340 KLTH0F08558p XP_002554575.1 741154 R 559295 CDS KLTH0F08580g 255716590 8292782 complement(743360..744994) 1 NC_013082.1 highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p essential protein that is required for the assembly of actin and tubulins in vivo contains an ATP-binding motif; KLTH0F08580p 744994 8292782 KLTH0F08580g Lachancea thermotolerans CBS 6340 KLTH0F08580p XP_002554576.1 743360 R 559295 CDS KLTH0F08602g 255716592 8292783 complement(745257..746375) 1 NC_013082.1 highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map2p; KLTH0F08602p 746375 8292783 KLTH0F08602g Lachancea thermotolerans CBS 6340 KLTH0F08602p XP_002554577.1 745257 R 559295 CDS KLTH0F08624g 255716594 8292784 complement(746527..746970) 1 NC_013082.1 similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified localizes to both the nucleus and cytoplasm; KLTH0F08624p 746970 8292784 KLTH0F08624g Lachancea thermotolerans CBS 6340 KLTH0F08624p XP_002554578.1 746527 R 559295 CDS KLTH0F08646g 255716596 8292785 748172..750319 1 NC_013082.1 some similarities with uniprot|Q04007 Saccharomyces cerevisiae YDR186C Hypothetical ORF; KLTH0F08646p 750319 8292785 KLTH0F08646g Lachancea thermotolerans CBS 6340 KLTH0F08646p XP_002554579.1 748172 D 559295 CDS KLTH0F08668g 255716598 8292786 750644..751720 1 NC_013082.1 similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase composed of Erf2p and Shr5p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage mutants partially mislocalize Ras2p to the vacuole; KLTH0F08668p 751720 8292786 KLTH0F08668g Lachancea thermotolerans CBS 6340 KLTH0F08668p XP_002554580.1 750644 D 559295 CDS KLTH0F08690g 255716600 8292787 751956..752651 1 NC_013082.1 similar to uniprot|P35200 Saccharomyces cerevisiae YLR168C possibly involved in intramitochondrial sorting; KLTH0F08690p 752651 8292787 KLTH0F08690g Lachancea thermotolerans CBS 6340 KLTH0F08690p XP_002554581.1 751956 D 559295 CDS KLTH0F08712g 255716602 8292788 753723..754628 1 NC_013082.1 weakly similar to uniprot|Q6Q540 Saccharomyces cerevisiae YDR184C ATC1 Nuclear protein possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; KLTH0F08712p 754628 8292788 KLTH0F08712g Lachancea thermotolerans CBS 6340 KLTH0F08712p XP_002554582.1 753723 D 559295 CDS KLTH0F08734g 255716604 8292789 complement(754886..755338) 1 NC_013082.1 similar to uniprot|P61864 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; KLTH0F08734p 755338 8292789 KLTH0F08734g Lachancea thermotolerans CBS 6340 KLTH0F08734p XP_002554583.1 754886 R 559295 CDS KLTH0F08756g 255716606 8292790 complement(756365..757000) 1 NC_013082.1 similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W; KLTH0F08756p 757000 8292790 KLTH0F08756g Lachancea thermotolerans CBS 6340 KLTH0F08756p XP_002554584.1 756365 R 559295 CDS KLTH0F08778g 255716608 8292791 757129..759579 1 NC_013082.1 similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; KLTH0F08778p 759579 8292791 KLTH0F08778g Lachancea thermotolerans CBS 6340 KLTH0F08778p XP_002554585.1 757129 D 559295 CDS KLTH0F08800g 255716610 8292792 complement(759621..761054) 1 NC_013082.1 similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis mutants display actin and general growth defects heterogeneous cell cycle arrests and pleiotropic defects in cell cycle progression and organelle distribution; KLTH0F08800p 761054 8292792 KLTH0F08800g Lachancea thermotolerans CBS 6340 KLTH0F08800p XP_002554586.1 759621 R 559295 CDS KLTH0F08822g 255716612 8292793 761180..762307 1 NC_013082.1 weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181c SAS4; KLTH0F08822p 762307 8292793 KLTH0F08822g Lachancea thermotolerans CBS 6340 KLTH0F08822p XP_002554587.1 761180 D 559295 CDS KLTH0F08844g 255716614 8292794 complement(762345..766739) 1 NC_013082.1 similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Sister chromatid cohesion protein; KLTH0F08844p 766739 8292794 KLTH0F08844g Lachancea thermotolerans CBS 6340 KLTH0F08844p XP_002554588.1 762345 R 559295 CDS KLTH0F08866g 255716616 8292795 766998..767702 1 NC_013082.1 similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5; KLTH0F08866p 767702 8292795 KLTH0F08866g Lachancea thermotolerans CBS 6340 KLTH0F08866p XP_002554589.1 766998 D 559295 CDS KLTH0F08888g 255716618 8292796 complement(767699..768955) 1 NC_013082.1 weakly similar to uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Hypothetical ORF; KLTH0F08888p 768955 8292796 KLTH0F08888g Lachancea thermotolerans CBS 6340 KLTH0F08888p XP_002554590.1 767699 R 559295 CDS KLTH0F08910g 255716620 8292797 769071..769583 1 NC_013082.1 similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin- like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling; KLTH0F08910p 769583 8292797 KLTH0F08910g Lachancea thermotolerans CBS 6340 KLTH0F08910p XP_002554591.1 769071 D 559295 CDS KLTH0F08932g 255716622 8292798 complement(769681..770193) 1 NC_013082.1 similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; KLTH0F08932p 770193 8292798 KLTH0F08932g Lachancea thermotolerans CBS 6340 KLTH0F08932p XP_002554592.1 769681 R 559295 CDS KLTH0F08954g 255716624 8292799 770605..771981 1 NC_013082.1 highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; KLTH0F08954p 771981 8292799 KLTH0F08954g Lachancea thermotolerans CBS 6340 KLTH0F08954p XP_002554593.1 770605 D 559295 CDS KLTH0F08976g 255716626 8292800 complement(772024..773994) 1 NC_013082.1 similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes component of transcriptional adaptor and histone acetyltransferase complexes the ADA complex the SAGA complex and the SLIK complex; KLTH0F08976p 773994 8292800 KLTH0F08976g Lachancea thermotolerans CBS 6340 KLTH0F08976p XP_002554594.1 772024 R 559295 CDS KLTH0F08998g 255716628 8292801 774288..775193 1 NC_013082.1 similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit; KLTH0F08998p 775193 8292801 KLTH0F08998g Lachancea thermotolerans CBS 6340 KLTH0F08998p XP_002554595.1 774288 D 559295 CDS KLTH0F09020g 255716630 8292802 complement(join(775420..776130,776219..776260)) 1 NC_013082.1 similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance rDNA- binding component of the Pol I transcription system associates with a 5'-3' DNA helicase and Fpr1p a prolyl isomerase; KLTH0F09020p 776260 8292802 KLTH0F09020g Lachancea thermotolerans CBS 6340 KLTH0F09020p XP_002554596.1 775420 R 559295 CDS KLTH0F09042g 255716632 8292803 complement(776944..778524) 1 NC_013082.1 weakly similar to uniprot|Q07904 YLR004C Saccharomyces cerevisiae YLR004C Hypothetical ORF; KLTH0F09042p 778524 8292803 KLTH0F09042g Lachancea thermotolerans CBS 6340 KLTH0F09042p XP_002554597.1 776944 R 559295 CDS KLTH0F09064g 255716634 8292804 779431..780516 1 NC_013082.1 similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low- zinc conditions by the Zap1p transcription factor; KLTH0F09064p 780516 8292804 KLTH0F09064g Lachancea thermotolerans CBS 6340 KLTH0F09064p XP_002554598.1 779431 D 559295 CDS KLTH0F09086g 255716636 8292805 781067..782071 1 NC_013082.1 similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Protein involved in regulation of arginine- responsive and Mcm1p-dependent genes has a dual- specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen- responsive genes; KLTH0F09086p 782071 8292805 KLTH0F09086g Lachancea thermotolerans CBS 6340 KLTH0F09086p XP_002554599.1 781067 D 559295 CDS KLTH0F09108g 255716638 8292806 complement(782647..784806) 1 NC_013082.1 some similarities with uniprot|P05453 Saccharomyces cerevisiae YDR172W SUP35 Translation termination factor eRF3 altered protein conformation creates the [PSI( )] prion a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; KLTH0F09108p 784806 8292806 KLTH0F09108g Lachancea thermotolerans CBS 6340 KLTH0F09108p XP_002554600.1 782647 R 559295 CDS KLTH0F09130g 255716640 8292807 complement(785577..786575) 1 NC_013082.1 some similarities with uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins oligomer dissociation is not required for function involved in cytoskeleton reorganization after heat shock; KLTH0F09130p 786575 8292807 KLTH0F09130g Lachancea thermotolerans CBS 6340 KLTH0F09130p XP_002554601.1 785577 R 559295 CDS KLTH0F09174g 255716642 8292809 complement(787684..789021) 1 NC_013082.1 conserved hypothetical protein; KLTH0F09174p 789021 8292809 KLTH0F09174g Lachancea thermotolerans CBS 6340 KLTH0F09174p XP_002554602.1 787684 R 559295 CDS KLTH0F09196g 255716644 8292810 790623..796013 1 NC_013082.1 similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi intra-Golgi transport and ER-to- Golgi transport found in the cytoplasm and on Golgi- associated coated vesicles; KLTH0F09196p 796013 8292810 KLTH0F09196g Lachancea thermotolerans CBS 6340 KLTH0F09196p XP_002554603.1 790623 D 559295 CDS KLTH0F09218g 255716646 8292811 796555..797685 1 NC_013082.1 highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase catalyzes the conversion of 5- enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate which is a precursor to aromatic amino acids; KLTH0F09218p 797685 8292811 KLTH0F09218g Lachancea thermotolerans CBS 6340 KLTH0F09218p XP_002554604.1 796555 D 559295 CDS KLTH0F09240g 255716648 8292812 799558..802224 1 NC_013082.1 similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring mutant phenotype and genetic interactions suggest a role in cytokinesis; KLTH0F09240p 802224 8292812 KLTH0F09240g Lachancea thermotolerans CBS 6340 KLTH0F09240p XP_002554605.1 799558 D 559295 CDS KLTH0F09262g 255716650 8292813 802460..804619 1 NC_013082.1 similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup85p Nup120p Nup145p-C Sec13p and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis; KLTH0F09262p 804619 8292813 KLTH0F09262g Lachancea thermotolerans CBS 6340 KLTH0F09262p XP_002554606.1 802460 D 559295 CDS KLTH0F09284g 255716652 8292814 complement(804826..805401) 1 NC_013082.1 highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; KLTH0F09284p 805401 8292814 KLTH0F09284g Lachancea thermotolerans CBS 6340 KLTH0F09284p XP_002554607.1 804826 R 559295 CDS KLTH0F09306g 255716654 8292815 complement(805770..806477) 1 NC_013082.1 similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 Protein of unknown function deletion causes hypersensitivity to the K1 killer toxin; KLTH0F09306p 806477 8292815 KLTH0F09306g Lachancea thermotolerans CBS 6340 KLTH0F09306p XP_002554608.1 805770 R 559295 CDS KLTH0F09328g 255716656 8292816 complement(807097..808947) 1 NC_013082.1 similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway binds phosphatidylinositol-3-phosphate involved in localization of membranes to the preautophagosome potential Cdc28p substrate; KLTH0F09328p 808947 8292816 KLTH0F09328g Lachancea thermotolerans CBS 6340 KLTH0F09328p XP_002554609.1 807097 R 559295 CDS KLTH0F09350g 255716658 8292817 809231..813421 1 NC_013082.1 similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; KLTH0F09350p 813421 8292817 KLTH0F09350g Lachancea thermotolerans CBS 6340 KLTH0F09350p XP_002554610.1 809231 D 559295 CDS KLTH0F09372g 255716660 8292818 complement(813488..814279) 1 NC_013082.1 similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Ribosomal RNA Processing Component of the exosome 3->5 exoribonuclease complex with Rrp4p Rrp41p Rrp43p and Dis3p (Rrp44p).; KLTH0F09372p 814279 8292818 KLTH0F09372g Lachancea thermotolerans CBS 6340 KLTH0F09372p XP_002554611.1 813488 R 559295 CDS KLTH0F09394g 255716662 8292819 complement(814413..815351) 1 NC_013082.1 weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C Hypothetical ORF; KLTH0F09394p 815351 8292819 KLTH0F09394g Lachancea thermotolerans CBS 6340 KLTH0F09394p XP_002554612.1 814413 R 559295 CDS KLTH0F09416g 255716664 8292820 complement(815432..815893) 1 NC_013082.1 similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C Hypothetical ORF; KLTH0F09416p 815893 8292820 KLTH0F09416g Lachancea thermotolerans CBS 6340 KLTH0F09416p XP_002554613.1 815432 R 559295 CDS KLTH0F09438g 255716666 8292821 818524..820551 1 NC_013082.1 similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 transport protein that interacts with Sec20p required for protein transport from the endoplasmic reticulum to the golgi apparatus; KLTH0F09438p 820551 8292821 KLTH0F09438g Lachancea thermotolerans CBS 6340 KLTH0F09438p XP_002554614.1 818524 D 559295 CDS KLTH0F09460g 255716668 8292822 complement(820558..822564) 1 NC_013082.1 similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C ROG1 and similar to uniprot|Q12103 Saccharomyces cerevisiae YDL109C Hypothetical ORF; KLTH0F09460p 822564 8292822 KLTH0F09460g Lachancea thermotolerans CBS 6340 KLTH0F09460p XP_002554615.1 820558 R 559295 CDS KLTH0F09482g 255716670 8292823 complement(823401..824603) 1 NC_013082.1 similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial polypeptide chain release factor involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation lack of MRF1 causes mitochondrial genome instability; KLTH0F09482p 824603 8292823 KLTH0F09482g Lachancea thermotolerans CBS 6340 KLTH0F09482p XP_002554616.1 823401 R 559295 CDS KLTH0F09504g 255716672 8292824 join(824743..824770,824831..825729) 1 NC_013082.1 highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase subunit of the transcription factor TFIIH involved in transcription initiation at RNA polymerase II promoters; KLTH0F09504p 825729 8292824 KLTH0F09504g Lachancea thermotolerans CBS 6340 KLTH0F09504p XP_002554617.1 824743 D 559295 CDS KLTH0F09526g 255716674 8292825 complement(825741..826970) 1 NC_013082.1 conserved hypothetical protein; KLTH0F09526p 826970 8292825 KLTH0F09526g Lachancea thermotolerans CBS 6340 KLTH0F09526p XP_002554618.1 825741 R 559295 CDS KLTH0F09548g 255716676 8292826 827100..828278 1 NC_013082.1 similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix required for export of C-terminal tail of Cox2p through the inner membrane; KLTH0F09548p 828278 8292826 KLTH0F09548g Lachancea thermotolerans CBS 6340 KLTH0F09548p XP_002554619.1 827100 D 559295 CDS KLTH0F09570g 255716678 8292827 complement(828282..830075) 1 NC_013082.1 similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1 2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog; KLTH0F09570p 830075 8292827 KLTH0F09570g Lachancea thermotolerans CBS 6340 KLTH0F09570p XP_002554620.1 828282 R 559295 CDS KLTH0F09592g 255716680 8292828 830181..832910 1 NC_013082.1 similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W; KLTH0F09592p 832910 8292828 KLTH0F09592g Lachancea thermotolerans CBS 6340 KLTH0F09592p XP_002554621.1 830181 D 559295 CDS KLTH0F09614g 255716682 8292829 833092..834609 1 NC_013082.1 similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C Endosomal protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p; KLTH0F09614p 834609 8292829 KLTH0F09614g Lachancea thermotolerans CBS 6340 KLTH0F09614p XP_002554622.1 833092 D 559295 CDS KLTH0F09636g 255716684 8292830 complement(834845..836299) 1 NC_013082.1 similar to uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p; KLTH0F09636p 836299 8292830 KLTH0F09636g Lachancea thermotolerans CBS 6340 KLTH0F09636p XP_002554623.1 834845 R 559295 CDS KLTH0F09658g 255716686 8292831 complement(836662..838173) 1 NC_013082.1 similar to uniprot|P47771 Saccharomyces cerevisiae YMR170c ALD5 and to YMR169c uniprot|P54114 Saccharomyces cerevisiae YMR169c ALD4; KLTH0F09658p 838173 8292831 KLTH0F09658g Lachancea thermotolerans CBS 6340 KLTH0F09658p XP_002554624.1 836662 R 559295 CDS KLTH0F09680g 255716688 8292832 839033..840541 1 NC_013082.1 similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytosolic aldehyde dehydrogenase that uses NAD as the preferred coenzyme expression is induced in response to high osmotic stress; KLTH0F09680p 840541 8292832 KLTH0F09680g Lachancea thermotolerans CBS 6340 KLTH0F09680p XP_002554625.1 839033 D 559295 CDS KLTH0F09702g 255716690 8292833 840760..842589 1 NC_013082.1 similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein component of the CBF3 complex that binds the CDEIII region of the centromere contains an N-terminal Zn2Cys6 type zinc finger domain a C-terminal acidic domain and a putative coiled coil dimerization domain; KLTH0F09702p 842589 8292833 KLTH0F09702g Lachancea thermotolerans CBS 6340 KLTH0F09702p XP_002554626.1 840760 D 559295 CDS KLTH0F09724g 255716692 8292834 complement(join(842593..844758,844826..844849)) 1 NC_013082.1 similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1; KLTH0F09724p 844849 8292834 KLTH0F09724g Lachancea thermotolerans CBS 6340 KLTH0F09724p XP_002554627.1 842593 R 559295 CDS KLTH0F09746g 255716694 8292835 844961..846112 1 NC_013082.1 similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex; KLTH0F09746p 846112 8292835 KLTH0F09746g Lachancea thermotolerans CBS 6340 KLTH0F09746p XP_002554628.1 844961 D 559295 CDS KLTH0F09768g 255716696 8292836 complement(846278..847453) 1 NC_013082.1 similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C; KLTH0F09768p 847453 8292836 KLTH0F09768g Lachancea thermotolerans CBS 6340 KLTH0F09768p XP_002554629.1 846278 R 559295 CDS KLTH0F09790g 255716698 8292837 847760..848833 1 NC_013082.1 similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C; KLTH0F09790p 848833 8292837 KLTH0F09790g Lachancea thermotolerans CBS 6340 KLTH0F09790p XP_002554630.1 847760 D 559295 CDS KLTH0F09812g 255716700 8292838 849268..851634 1 NC_013082.1 similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C SMP2 Protein involved in respiration and plasmid maintenance; KLTH0F09812p 851634 8292838 KLTH0F09812g Lachancea thermotolerans CBS 6340 KLTH0F09812p XP_002554631.1 849268 D 559295 CDS KLTH0F09834g 255716702 8292839 852041..853669 1 NC_013082.1 some similarities with uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation controls the activation of MUC1 and STA2 in response to nutritional signals; KLTH0F09834p 853669 8292839 KLTH0F09834g Lachancea thermotolerans CBS 6340 KLTH0F09834p XP_002554632.1 852041 D 559295 CDS KLTH0F09878g 255716704 8292841 854476..856575 1 NC_013082.1 weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F09878p 856575 8292841 KLTH0F09878g Lachancea thermotolerans CBS 6340 KLTH0F09878p XP_002554633.1 854476 D 559295 CDS KLTH0F09900g 255716706 8292842 complement(856617..858035) 1 NC_013082.1 similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase catalyzes the formation of UDP-N- acetylglucosamine (UDP- GlcNAc) which is important in cell wall biosynthesis protein N-glycosylation and GPI anchor biosynthesis; KLTH0F09900p 858035 8292842 KLTH0F09900g Lachancea thermotolerans CBS 6340 KLTH0F09900p XP_002554634.1 856617 R 559295 CDS KLTH0F09922g 255716708 8292843 858143..862984 1 NC_013082.1 similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the trans-Golgi likely involved in protein transport; KLTH0F09922p 862984 8292843 KLTH0F09922g Lachancea thermotolerans CBS 6340 KLTH0F09922p XP_002554635.1 858143 D 559295 CDS KLTH0F09944g 255716710 8292844 complement(863160..863861) 1 NC_013082.1 some similarities with uniprot|P48353 Saccharomyces cerevisiae YMR161W; KLTH0F09944p 863861 8292844 KLTH0F09944g Lachancea thermotolerans CBS 6340 KLTH0F09944p XP_002554636.1 863160 R 559295 CDS KLTH0F09966g 255716712 8292845 865335..868622 1 NC_013082.1 highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W CDC2 Catalytic subunit of DNA polymerase delta required for chromosomal DNA replication during mitosis and meiosis intragenic recombination repair of double strand DNA breaks and DNA replication during nucleotide excision repair (NER); KLTH0F09966p 868622 8292845 KLTH0F09966g Lachancea thermotolerans CBS 6340 KLTH0F09966p XP_002554637.1 865335 D 559295 CDS KLTH0F09988g 255716714 8292846 complement(868693..869931) 1 NC_013082.1 similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes phosphorylation of Rad55p and Sml1p and transient G2/M arrest after DNA damage also regulates postreplicative DNA repair; KLTH0F09988p 869931 8292846 KLTH0F09988g Lachancea thermotolerans CBS 6340 KLTH0F09988p XP_002554638.1 868693 R 559295 CDS KLTH0F10010g 255716716 8292847 complement(870395..872626) 1 NC_013082.1 similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Hypothetical ORF; KLTH0F10010p 872626 8292847 KLTH0F10010g Lachancea thermotolerans CBS 6340 KLTH0F10010p XP_002554639.1 870395 R 559295 CDS KLTH0F10032g 255716718 8292848 872882..873247 1 NC_013082.1 weakly similar to uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre- autophagosomal structure essential for autophagy; KLTH0F10032p 873247 8292848 KLTH0F10032g Lachancea thermotolerans CBS 6340 KLTH0F10032p XP_002554640.1 872882 D 559295 CDS KLTH0F10098g 255716720 8292851 complement(874521..875570) 1 NC_013082.1 highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C ARR4 ATPase involved in resistance to heat and metal stress active as a dimer normally localized to the cytosol but appears to localize to late endosomes under stress conditions; KLTH0F10098p 875570 8292851 KLTH0F10098g Lachancea thermotolerans CBS 6340 KLTH0F10098p XP_002554641.1 874521 R 559295 CDS KLTH0F10120g 255716722 8292852 875820..876821 1 NC_013082.1 weakly similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F10120p 876821 8292852 KLTH0F10120g Lachancea thermotolerans CBS 6340 KLTH0F10120p XP_002554642.1 875820 D 559295 CDS KLTH0F10142g 255716724 8292853 complement(876890..877357) 1 NC_013082.1 highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit; KLTH0F10142p 877357 8292853 KLTH0F10142g Lachancea thermotolerans CBS 6340 KLTH0F10142p XP_002554643.1 876890 R 559295 CDS KLTH0F10164g 255716726 8292854 877585..878268 1 NC_013082.1 similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C FMP39 The authentic non-tagged protein was localized to the mitochondria; KLTH0F10164p 878268 8292854 KLTH0F10164g Lachancea thermotolerans CBS 6340 KLTH0F10164p XP_002554644.1 877585 D 559295 CDS KLTH0F10186g 255716728 8292855 complement(878318..878878) 1 NC_013082.1 similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 23 kD U4/U6.U5 snRNP associated protein Putative RNA binding zinc finger protein; KLTH0F10186p 878878 8292855 KLTH0F10186g Lachancea thermotolerans CBS 6340 KLTH0F10186p XP_002554645.1 878318 R 559295 CDS KLTH0F10208g 255716730 8292856 878993..879715 1 NC_013082.1 similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage functionally redundant with Apn1p and Apn2p; KLTH0F10208p 879715 8292856 KLTH0F10208g Lachancea thermotolerans CBS 6340 KLTH0F10208p XP_002554646.1 878993 D 559295 CDS KLTH0F10230g 255716732 8292857 complement(879777..881045) 1 NC_013082.1 highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome the human homolog (S9 protein) partially rescues Rpn6p depletion; KLTH0F10230p 881045 8292857 KLTH0F10230g Lachancea thermotolerans CBS 6340 KLTH0F10230p XP_002554647.1 879777 R 559295 CDS KLTH0F10252g 255716734 8292858 882483..884990 1 NC_013082.1 similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway acts in complex with Pmt2p dolichyl phosphate-D-mannose:protein O- D- mannosyltransferase; KLTH0F10252p 884990 8292858 KLTH0F10252g Lachancea thermotolerans CBS 6340 KLTH0F10252p XP_002554648.1 882483 D 559295 CDS KLTH0F10274g 255716736 8292859 complement(885132..887042) 1 NC_013082.1 some similarities with uniprot|Q03795 Saccharomyces cerevisiae YMR155W Hypothetical ORF; KLTH0F10274p 887042 8292859 KLTH0F10274g Lachancea thermotolerans CBS 6340 KLTH0F10274p XP_002554649.1 885132 R 559295 CDS KLTH0F10296g 255716738 8292860 888200..888613 1 NC_013082.1 similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle subunit; KLTH0F10296p 888613 8292860 KLTH0F10296g Lachancea thermotolerans CBS 6340 KLTH0F10296p XP_002554650.1 888200 D 559295 CDS KLTH0F10318g 255716740 8292861 complement(888664..889947) 1 NC_013082.1 similar to uniprot|Q12229 YDL091c Saccharomyces cerevisiae UBX3 UBX domain-containing protein that interacts with Cdc48p; KLTH0F10318p 889947 8292861 KLTH0F10318g Lachancea thermotolerans CBS 6340 KLTH0F10318p XP_002554651.1 888664 R 559295 CDS KLTH0F10340g 255716742 8292862 complement(890083..891582) 1 NC_013082.1 similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 essential for processing of ras proteins beta subunit of farnesyltransferase; KLTH0F10340p 891582 8292862 KLTH0F10340g Lachancea thermotolerans CBS 6340 KLTH0F10340p XP_002554652.1 890083 R 559295 CDS KLTH0F10362g 255716744 8292863 complement(891631..892674) 1 NC_013082.1 some similarities with uniprot|P10080 Saccharomyces cerevisiae YHL034C SBP1 Single-strand nucleic acid binding protein; KLTH0F10362p 892674 8292863 KLTH0F10362g Lachancea thermotolerans CBS 6340 KLTH0F10362p XP_002554653.1 891631 R 559295 CDS KLTH0F10384g 255716746 8292864 893564..897757 1 NC_013082.1 highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase; KLTH0F10384p 897757 8292864 KLTH0F10384g Lachancea thermotolerans CBS 6340 KLTH0F10384p XP_002554654.1 893564 D 559295 CDS KLTH0F10406g 255716748 8292865 complement(897851..900148) 1 NC_013082.1 highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family; KLTH0F10406p 900148 8292865 KLTH0F10406g Lachancea thermotolerans CBS 6340 KLTH0F10406p XP_002554655.1 897851 R 559295 CDS KLTH0F10428g 255716750 8292866 902697..905084 1 NC_013082.1 highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co- repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; KLTH0F10428p 905084 8292866 KLTH0F10428g Lachancea thermotolerans CBS 6340 KLTH0F10428p XP_002554656.1 902697 D 559295 CDS KLTH0F10450g 255716752 8292867 complement(join(905240..905319,905391..905530,905624..905703)) 1 NC_013082.1 similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex; KLTH0F10450p 905703 8292867 KLTH0F10450g Lachancea thermotolerans CBS 6340 KLTH0F10450p XP_002554657.1 905240 R 559295 CDS KLTH0F10472g 255716754 8292868 905820..906524 1 NC_013082.1 similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C; KLTH0F10472p 906524 8292868 KLTH0F10472g Lachancea thermotolerans CBS 6340 KLTH0F10472p XP_002554658.1 905820 D 559295 CDS KLTH0F10538g 255716756 8292871 complement(907083..908417) 1 NC_013082.1 weakly similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 Subunit 1 of the Mediator complex essential for transcriptional regulation; KLTH0F10538p 908417 8292871 KLTH0F10538g Lachancea thermotolerans CBS 6340 KLTH0F10538p XP_002554659.1 907083 R 559295 CDS KLTH0F10560g 255716758 8292872 909235..910119 1 NC_013082.1 highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase); KLTH0F10560p 910119 8292872 KLTH0F10560g Lachancea thermotolerans CBS 6340 KLTH0F10560p XP_002554660.1 909235 D 559295 CDS KLTH0F10582g 255716760 8292873 910298..911722 1 NC_013082.1 similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C; KLTH0F10582p 911722 8292873 KLTH0F10582g Lachancea thermotolerans CBS 6340 KLTH0F10582p XP_002554661.1 910298 D 559295 CDS KLTH0F10604g 255716762 8292874 complement(911719..913062) 1 NC_013082.1 similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum; KLTH0F10604p 913062 8292874 KLTH0F10604g Lachancea thermotolerans CBS 6340 KLTH0F10604p XP_002554662.1 911719 R 559295 CDS KLTH0F10626g 255716764 8292875 913468..913911 1 NC_013082.1 highly similar to uniprot|P06787 Saccharomyces cerevisiae YBR109C CMD1 master regulator of calcium mediated signalling Calmodulin; KLTH0F10626p 913911 8292875 KLTH0F10626g Lachancea thermotolerans CBS 6340 KLTH0F10626p XP_002554663.1 913468 D 559295 CDS KLTH0F10648g 255716766 8292876 complement(914033..916561) 1 NC_013082.1 similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W Protein interacting with Rsv167p; KLTH0F10648p 916561 8292876 KLTH0F10648g Lachancea thermotolerans CBS 6340 KLTH0F10648p XP_002554664.1 914033 R 559295 CDS KLTH0F10670g 255716768 8292877 916674..917381 1 NC_013082.1 no similarity; KLTH0F10670p 917381 8292877 KLTH0F10670g Lachancea thermotolerans CBS 6340 KLTH0F10670p XP_002554665.1 916674 D 559295 CDS KLTH0F10692g 255716770 8292878 complement(917384..917950) 1 NC_013082.1 similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2; KLTH0F10692p 917950 8292878 KLTH0F10692g Lachancea thermotolerans CBS 6340 KLTH0F10692p XP_002554666.1 917384 R 559295 CDS KLTH0F10714g 255716772 8292879 complement(918159..919100) 1 NC_013082.1 similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F10714p 919100 8292879 KLTH0F10714g Lachancea thermotolerans CBS 6340 KLTH0F10714p XP_002554667.1 918159 R 559295 CDS KLTH0F10736g 255716774 8292880 complement(919274..919846) 1 NC_013082.1 highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport; KLTH0F10736p 919846 8292880 KLTH0F10736g Lachancea thermotolerans CBS 6340 KLTH0F10736p XP_002554668.1 919274 R 559295 CDS KLTH0F10758g 255716776 8292881 920547..921416 1 NC_013082.1 highly similar to uniprot|P06380 Saccharomyces cerevisiae RPL11A and to uniprot|P06380 Saccharomyces cerevisiae YGR085C RPL11B component of the large (60S) ribosomal subunit; KLTH0F10758p 921416 8292881 KLTH0F10758g Lachancea thermotolerans CBS 6340 KLTH0F10758p XP_002554669.1 920547 D 559295 CDS KLTH0F10780g 255716778 8292882 complement(921544..922128) 1 NC_013082.1 weakly similar to uniprot|Q06091 Saccharomyces cerevisiae YPR101W SNT309 Component of a protein complex associated with the splicing factor Prp19p, essential for mRNA splicing; KLTH0F10780p 922128 8292882 KLTH0F10780g Lachancea thermotolerans CBS 6340 KLTH0F10780p XP_002554670.1 921544 R 559295 CDS KLTH0F10802g 255716780 8292883 922439..923386 1 NC_013082.1 weakly similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit; KLTH0F10802p 923386 8292883 KLTH0F10802g Lachancea thermotolerans CBS 6340 KLTH0F10802p XP_002554671.1 922439 D 559295 CDS KLTH0F10824g 255716782 8292884 923729..925018 1 NC_013082.1 weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C Hypothetical ORF; KLTH0F10824p 925018 8292884 KLTH0F10824g Lachancea thermotolerans CBS 6340 KLTH0F10824p XP_002554672.1 923729 D 559295 CDS KLTH0F10846g 255716784 8292885 925263..927110 1 NC_013082.1 similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; KLTH0F10846p 927110 8292885 KLTH0F10846g Lachancea thermotolerans CBS 6340 KLTH0F10846p XP_002554673.1 925263 D 559295 CDS KLTH0F10868g 255716786 8292886 complement(927250..927681) 1 NC_013082.1 highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit; KLTH0F10868p 927681 8292886 KLTH0F10868g Lachancea thermotolerans CBS 6340 KLTH0F10868p XP_002554674.1 927250 R 559295 CDS KLTH0F10890g 255716788 8292887 928161..928487 1 NC_013082.1 similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF; KLTH0F10890p 928487 8292887 KLTH0F10890g Lachancea thermotolerans CBS 6340 KLTH0F10890p XP_002554675.1 928161 D 559295 CDS KLTH0F10912g 255716790 8292888 complement(928673..929257) 1 NC_013082.1 similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane; KLTH0F10912p 929257 8292888 KLTH0F10912g Lachancea thermotolerans CBS 6340 KLTH0F10912p XP_002554676.1 928673 R 559295 CDS KLTH0F10934g 255716792 8292889 929852..930439 1 NC_013082.1 similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C; KLTH0F10934p 930439 8292889 KLTH0F10934g Lachancea thermotolerans CBS 6340 KLTH0F10934p XP_002554677.1 929852 D 559295 CDS KLTH0F10956g 255716794 8292890 complement(930493..933468) 1 NC_013082.1 similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein; KLTH0F10956p 933468 8292890 KLTH0F10956g Lachancea thermotolerans CBS 6340 KLTH0F10956p XP_002554678.1 930493 R 559295 CDS KLTH0F11000g 255716796 8292892 934247..937168 1 NC_013082.1 some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3; KLTH0F11000p 937168 8292892 KLTH0F11000g Lachancea thermotolerans CBS 6340 KLTH0F11000p XP_002554679.1 934247 D 559295 CDS KLTH0F11022g 255716798 8292893 complement(937194..937517) 1 NC_013082.1 highly similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein; KLTH0F11022p 937517 8292893 KLTH0F11022g Lachancea thermotolerans CBS 6340 KLTH0F11022p XP_002554680.1 937194 R 559295 CDS KLTH0F11044g 255716800 8292894 937668..938543 1 NC_013082.1 weakly similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain; KLTH0F11044p 938543 8292894 KLTH0F11044g Lachancea thermotolerans CBS 6340 KLTH0F11044p XP_002554681.1 937668 D 559295 CDS KLTH0F11066g 255716802 8292895 complement(938597..939562) 1 NC_013082.1 similar to uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p); KLTH0F11066p 939562 8292895 KLTH0F11066g Lachancea thermotolerans CBS 6340 KLTH0F11066p XP_002554682.1 938597 R 559295 CDS KLTH0F11088g 255716804 8292896 complement(939970..940629) 1 NC_013082.1 conserved hypothetical protein; KLTH0F11088p 940629 8292896 KLTH0F11088g Lachancea thermotolerans CBS 6340 KLTH0F11088p XP_002554683.1 939970 R 559295 CDS KLTH0F11176g 255716806 8293298 942194..944638 1 NC_013082.1 similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF; KLTH0F11176p 944638 8293298 KLTH0F11176g Lachancea thermotolerans CBS 6340 KLTH0F11176p XP_002554684.1 942194 D 559295 CDS KLTH0F11198g 255716808 8292898 complement(944703..951785) 1 NC_013082.1 similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination,regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol(PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis; KLTH0F11198p 951785 8292898 KLTH0F11198g Lachancea thermotolerans CBS 6340 KLTH0F11198p XP_002554685.1 944703 R 559295 CDS KLTH0F11220g 255716810 8292899 complement(952103..952435) 1 NC_013082.1 highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins; KLTH0F11220p 952435 8292899 KLTH0F11220g Lachancea thermotolerans CBS 6340 KLTH0F11220p XP_002554686.1 952103 R 559295 CDS KLTH0F11242g 255716812 8292900 954186..956594 1 NC_013082.1 similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization; KLTH0F11242p 956594 8292900 KLTH0F11242g Lachancea thermotolerans CBS 6340 KLTH0F11242p XP_002554687.1 954186 D 559295 CDS KLTH0F11264g 255716814 8292901 complement(956704..959058) 1 NC_013082.1 similar to uniprot|Q86ZS6 Saccharomyces cerevisiae YPR089W Hypothetical ORF; KLTH0F11264p 959058 8292901 KLTH0F11264g Lachancea thermotolerans CBS 6340 KLTH0F11264p XP_002554688.1 956704 R 559295 CDS KLTH0F11286g 255716816 8292902 959314..961062 1 NC_013082.1 similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease; KLTH0F11286p 961062 8292902 KLTH0F11286g Lachancea thermotolerans CBS 6340 KLTH0F11286p XP_002554689.1 959314 D 559295 CDS KLTH0F11330g 255716818 8292903 962129..962620 1 NC_013082.1 conserved hypothetical protein; KLTH0F11330p 962620 8292903 KLTH0F11330g Lachancea thermotolerans CBS 6340 KLTH0F11330p XP_002554690.1 962129 D 559295 CDS KLTH0F11352g 255716820 8292904 complement(962701..964596) 1 NC_013082.1 similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly; KLTH0F11352p 964596 8292904 KLTH0F11352g Lachancea thermotolerans CBS 6340 KLTH0F11352p XP_002554691.1 962701 R 559295 CDS KLTH0F11374g 255716822 8292905 965873..967477 1 NC_013082.1 similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) contains the signal sequence- binding activity of SRP interacts with the SRP RNA and mediates binding of SRP to signal receptor contains GTPase domain; KLTH0F11374p 967477 8292905 KLTH0F11374g Lachancea thermotolerans CBS 6340 KLTH0F11374p XP_002554692.1 965873 D 559295 CDS KLTH0F11396g 255716824 8292906 967691..968962 1 NC_013082.1 some similarities with uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud also required for cortical ER inheritance; KLTH0F11396p 968962 8292906 KLTH0F11396g Lachancea thermotolerans CBS 6340 KLTH0F11396p XP_002554693.1 967691 D 559295 CDS KLTH0F11418g 255716826 8292907 969077..970063 1 NC_013082.1 weakly similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone; KLTH0F11418p 970063 8292907 KLTH0F11418g Lachancea thermotolerans CBS 6340 KLTH0F11418p XP_002554694.1 969077 D 559295 CDS KLTH0F11440g 255716828 8292908 970205..971455 1 NC_013082.1 weakly similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C Protein required for cell viability; KLTH0F11440p 971455 8292908 KLTH0F11440g Lachancea thermotolerans CBS 6340 KLTH0F11440p XP_002554695.1 970205 D 559295 CDS KLTH0F11462g 255716830 8292909 complement(971534..972919) 1 NC_013082.1 similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Hypothetical ORF; KLTH0F11462p 972919 8292909 KLTH0F11462g Lachancea thermotolerans CBS 6340 KLTH0F11462p XP_002554696.1 971534 R 559295 CDS KLTH0F11484g 255716832 8292910 973231..974205 1 NC_013082.1 weakly similar to uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p Vps15p and Vps30p) required for organization of a pre- autophagosomal structure ATG14 transcription is activated by Gln3p during nitrogen starvation; KLTH0F11484p 974205 8292910 KLTH0F11484g Lachancea thermotolerans CBS 6340 KLTH0F11484p XP_002554697.1 973231 D 559295 CDS KLTH0F11506g 255716834 8292911 974710..976245 1 NC_013082.1 highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Vacuolar H ATPase regulatory subunit; KLTH0F11506p 976245 8292911 KLTH0F11506g Lachancea thermotolerans CBS 6340 KLTH0F11506p XP_002554698.1 974710 D 559295 CDS KLTH0F11528g 255716836 8292912 complement(976482..977978) 1 NC_013082.1 similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial Distribution and Morphology; KLTH0F11528p 977978 8292912 KLTH0F11528g Lachancea thermotolerans CBS 6340 KLTH0F11528p XP_002554699.1 976482 R 559295 CDS KLTH0F11550g 255716838 8292913 978906..980429 1 NC_013082.1 highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Probable regulator of glucose influx into the cell & into glycolytic pathway indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex; KLTH0F11550p 980429 8292913 KLTH0F11550g Lachancea thermotolerans CBS 6340 KLTH0F11550p XP_002554700.1 978906 D 559295 CDS KLTH0F11572g 255716840 8292914 980847..982034 1 NC_013082.1 similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity; KLTH0F11572p 982034 8292914 KLTH0F11572g Lachancea thermotolerans CBS 6340 KLTH0F11572p XP_002554701.1 980847 D 559295 CDS KLTH0F11594g 255716842 8292915 982237..984177 1 NC_013082.1 similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C, subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC); KLTH0F11594p 984177 8292915 KLTH0F11594g Lachancea thermotolerans CBS 6340 KLTH0F11594p XP_002554702.1 982237 D 559295 CDS KLTH0F11616g 255716844 8292916 984336..984878 1 NC_013082.1 similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit; KLTH0F11616p 984878 8292916 KLTH0F11616g Lachancea thermotolerans CBS 6340 KLTH0F11616p XP_002554703.1 984336 D 559295 CDS KLTH0F11638g 255716846 8292917 985064..985492 1 NC_013082.1 highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri- snRNP; KLTH0F11638p 985492 8292917 KLTH0F11638g Lachancea thermotolerans CBS 6340 KLTH0F11638p XP_002554704.1 985064 D 559295 CDS KLTH0F11660g 255716848 8292918 985924..987909 1 NC_013082.1 highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase; KLTH0F11660p 987909 8292918 KLTH0F11660g Lachancea thermotolerans CBS 6340 KLTH0F11660p XP_002554705.1 985924 D 559295 CDS KLTH0F11682g 255716850 8292919 988129..988599 1 NC_013082.1 similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA; KLTH0F11682p 988599 8292919 KLTH0F11682g Lachancea thermotolerans CBS 6340 KLTH0F11682p XP_002554706.1 988129 D 559295 CDS KLTH0F11704g 255716852 8292920 complement(988725..989963) 1 NC_013082.1 similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing; KLTH0F11704p 989963 8292920 KLTH0F11704g Lachancea thermotolerans CBS 6340 KLTH0F11704p XP_002554707.1 988725 R 559295 CDS KLTH0F11726g 255716854 8292921 complement(990165..991541) 1 NC_013082.1 uniprot|Q7Z8W9 Translation elongation factor 1- alpha; KLTH0F11726p 991541 8292921 KLTH0F11726g Lachancea thermotolerans CBS 6340 KLTH0F11726p XP_002554708.1 990165 R 559295 CDS KLTH0F11748g 255716856 8292922 complement(992126..993049) 1 NC_013082.1 similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein; KLTH0F11748p 993049 8292922 KLTH0F11748g Lachancea thermotolerans CBS 6340 KLTH0F11748p XP_002554709.1 992126 R 559295 CDS KLTH0F11792g 255716858 8292924 complement(993957..994721) 1 NC_013082.1 conserved hypothetical protein; KLTH0F11792p 994721 8292924 KLTH0F11792g Lachancea thermotolerans CBS 6340 KLTH0F11792p XP_002554710.1 993957 R 559295 CDS KLTH0F11814g 255716860 8292925 995425..996774 1 NC_013082.1 weakly similar to uniprot|Q6B149 Saccharomyces cerevisiae YPR075C OPY2 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone; KLTH0F11814p 996774 8292925 KLTH0F11814g Lachancea thermotolerans CBS 6340 KLTH0F11814p XP_002554711.1 995425 D 559295 CDS KLTH0F11836g 255716862 8292926 997547..999589 1 NC_013082.1 highly similar to uniprot|P23254 Saccharomyces cerevisiae TKL1 and to YBR117C uniprot|P33315 Saccharomyces cerevisiae TKL2 Transketolase; KLTH0F11836p 999589 8292926 KLTH0F11836g Lachancea thermotolerans CBS 6340 KLTH0F11836p XP_002554712.1 997547 D 559295 CDS KLTH0F11858g 255716864 8292927 999895..1000371 1 NC_013082.1 similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 phosphatase; KLTH0F11858p 1000371 8292927 KLTH0F11858g Lachancea thermotolerans CBS 6340 KLTH0F11858p XP_002554713.1 999895 D 559295 CDS KLTH0F11880g 255716866 8292928 complement(1000583..1002274) 1 NC_013082.1 highly similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator; KLTH0F11880p 1002274 8292928 KLTH0F11880g Lachancea thermotolerans CBS 6340 KLTH0F11880p XP_002554714.1 1000583 R 559295 CDS KLTH0F11902g 255716868 8292929 complement(1002844..1003758) 1 NC_013082.1 similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source; KLTH0F11902p 1003758 8292929 KLTH0F11902g Lachancea thermotolerans CBS 6340 KLTH0F11902p XP_002554715.1 1002844 R 559295 CDS KLTH0F11924g 255716870 8292930 1003953..1004627 1 NC_013082.1 similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'- >5' exonucleases; KLTH0F11924p 1004627 8292930 KLTH0F11924g Lachancea thermotolerans CBS 6340 KLTH0F11924p XP_002554716.1 1003953 D 559295 CDS KLTH0F11946g 255716872 8292931 complement(1004689..1007991) 1 NC_013082.1 highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase; KLTH0F11946p 1007991 8292931 KLTH0F11946g Lachancea thermotolerans CBS 6340 KLTH0F11946p XP_002554717.1 1004689 R 559295 CDS KLTH0F11968g 255716874 8292932 1008620..1011259 1 NC_013082.1 similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites shows partial nucleolar localization contains five consensus RNA- binding domains; KLTH0F11968p 1011259 8292932 KLTH0F11968g Lachancea thermotolerans CBS 6340 KLTH0F11968p XP_002554718.1 1008620 D 559295 CDS KLTH0F11990g 255716876 8292933 complement(join(1011318..1012803,1012880..1012890)) 1 NC_013082.1 similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Hypothetical ORF; KLTH0F11990p 1012890 8292933 KLTH0F11990g Lachancea thermotolerans CBS 6340 KLTH0F11990p XP_002554719.1 1011318 R 559295 CDS KLTH0F12012g 255716878 8292934 complement(1013169..1014881) 1 NC_013082.1 similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W DBF2 Ser/Thr kinase involved in transcription and stress response functions as part of a network of genes in exit from mitosis localization is cell cycle regulated activated by Cdc15p during the exit from mitosis; KLTH0F12012p 1014881 8292934 KLTH0F12012g Lachancea thermotolerans CBS 6340 KLTH0F12012p XP_002554720.1 1013169 R 559295 CDS KLTH0F12034g 255716880 8292935 complement(1015072..1016646) 1 NC_013082.1 weakly similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor component of the U4/U6-U5 snRNP complex; KLTH0F12034p 1016646 8292935 KLTH0F12034g Lachancea thermotolerans CBS 6340 KLTH0F12034p XP_002554721.1 1015072 R 559295 CDS KLTH0F12056g 255716882 8292936 1016695..1017747 1 NC_013082.1 highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit common to RNA polymerase I and III; KLTH0F12056p 1017747 8292936 KLTH0F12056g Lachancea thermotolerans CBS 6340 KLTH0F12056p XP_002554722.1 1016695 D 559295 CDS KLTH0F12078g 255716884 8292937 complement(1017863..1018759) 1 NC_013082.1 similar to uniprot|Q6B2S3 Saccharomyces cerevisiae YPR109W Hypothetical ORF; KLTH0F12078p 1018759 8292937 KLTH0F12078g Lachancea thermotolerans CBS 6340 KLTH0F12078p XP_002554723.1 1017863 R 559295 CDS KLTH0F12100g 255716886 8292938 complement(1019027..1022692) 1 NC_013082.1 similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; KLTH0F12100p 1022692 8292938 KLTH0F12100g Lachancea thermotolerans CBS 6340 KLTH0F12100p XP_002554724.1 1019027 R 559295 CDS KLTH0F12144g 255716888 8292940 complement(1023571..1026102) 1 NC_013082.1 weakly similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p which is a subunit of RNA polymerases I II and III computational analysis of large- scale protein-protein interaction data suggests a role in chromosome segregation; KLTH0F12144p 1026102 8292940 KLTH0F12144g Lachancea thermotolerans CBS 6340 KLTH0F12144p XP_002554725.1 1023571 R 559295 CDS KLTH0F12210g 255716890 8292943 complement(1028104..1029771) 1 NC_013082.1 similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide; KLTH0F12210p 1029771 8292943 KLTH0F12210g Lachancea thermotolerans CBS 6340 KLTH0F12210p XP_002554726.1 1028104 R 559295 CDS KLTH0F12232g 255716892 8292944 complement(1031104..1032330) 1 NC_013082.1 similar to uniprot|Q06103 Saccharomyces cerevisiae YPR108W; KLTH0F12232p 1032330 8292944 KLTH0F12232g Lachancea thermotolerans CBS 6340 KLTH0F12232p XP_002554727.1 1031104 R 559295 CDS KLTH0F12254g 255716894 8292945 complement(1032674..1033306) 1 NC_013082.1 similar to uniprot|Q12450 Saccharomyces cerevisiae YOR016C; KLTH0F12254p 1033306 8292945 KLTH0F12254g Lachancea thermotolerans CBS 6340 KLTH0F12254p XP_002554728.1 1032674 R 559295 CDS KLTH0F12276g 255716896 8292946 1036188..1036967 1 NC_013082.1 conserved hypothetical protein; KLTH0F12276p 1036967 8292946 KLTH0F12276g Lachancea thermotolerans CBS 6340 KLTH0F12276p XP_002554729.1 1036188 D 559295 CDS KLTH0F12320g 255716898 8292948 complement(1038006..1039154) 1 NC_013082.1 similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation; KLTH0F12320p 1039154 8292948 KLTH0F12320g Lachancea thermotolerans CBS 6340 KLTH0F12320p XP_002554730.1 1038006 R 559295 CDS KLTH0F12342g 255716900 8292949 complement(1039316..1040692) 1 NC_013082.1 similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 The authentic non-tagged protein was localized to the mitochondria; KLTH0F12342p 1040692 8292949 KLTH0F12342g Lachancea thermotolerans CBS 6340 KLTH0F12342p XP_002554731.1 1039316 R 559295 CDS KLTH0F12364g 255716902 8292950 1041008..1043299 1 NC_013082.1 weakly similar to uniprot|P32606 YOR017W Saccharomyces cerevisiae PET127 Protein with a role in mitochondrial RNA stability and/or processing; KLTH0F12364p 1043299 8292950 KLTH0F12364g Lachancea thermotolerans CBS 6340 KLTH0F12364p XP_002554732.1 1041008 D 559295 CDS KLTH0F12386g 255716904 8292951 complement(1043384..1044409) 1 NC_013082.1 similar to uniprot|Q03687 YMR010W Saccharomyces cerevisiae Protein of unknown function; KLTH0F12386p 1044409 8292951 KLTH0F12386g Lachancea thermotolerans CBS 6340 KLTH0F12386p XP_002554733.1 1043384 R 559295 CDS KLTH0F12408g 255716906 8292952 complement(1044689..1045219) 1 NC_013082.1 similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway; KLTH0F12408p 1045219 8292952 KLTH0F12408g Lachancea thermotolerans CBS 6340 KLTH0F12408p XP_002554734.1 1044689 R 559295 CDS KLTH0F12474g 255716908 8292955 1046386..1047798 1 NC_013082.1 similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall; KLTH0F12474p 1047798 8292955 KLTH0F12474g Lachancea thermotolerans CBS 6340 KLTH0F12474p XP_002554735.1 1046386 D 559295 CDS KLTH0F12496g 255716910 8292956 complement(1047883..1048668) 1 NC_013082.1 some similarities with uniprot|P40574 Saccharomyces cerevisiae YIR018W YAP5 bZIP transcription; KLTH0F12496p 1048668 8292956 KLTH0F12496g Lachancea thermotolerans CBS 6340 KLTH0F12496p XP_002554736.1 1047883 R 559295 CDS KLTH0F12518g 255716912 8292957 1049464..1050516 1 NC_013082.1 some similarities with uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Protein involved in cell wall integrity and stress response; KLTH0F12518p 1050516 8292957 KLTH0F12518g Lachancea thermotolerans CBS 6340 KLTH0F12518p XP_002554737.1 1049464 D 559295 CDS KLTH0F12540g 255716914 8292958 1050879..1052666 1 NC_013082.1 similar to uniprot|Q08977 YPL260W Saccharomyces cerevisiae Hypothetical ORF; KLTH0F12540p 1052666 8292958 KLTH0F12540g Lachancea thermotolerans CBS 6340 KLTH0F12540p XP_002554738.1 1050879 D 559295 CDS KLTH0F12562g 255716916 8292959 1052954..1053835 1 NC_013082.1 similar to uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase; KLTH0F12562p 1053835 8292959 KLTH0F12562g Lachancea thermotolerans CBS 6340 KLTH0F12562p XP_002554739.1 1052954 D 559295 CDS KLTH0F12584g 255716918 8292960 complement(1053944..1055269) 1 NC_013082.1 highly similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 medium subunit of the clathrin- associated protein complex; KLTH0F12584p 1055269 8292960 KLTH0F12584g Lachancea thermotolerans CBS 6340 KLTH0F12584p XP_002554740.1 1053944 R 559295 CDS KLTH0F12606g 255716920 8292961 complement(1055736..1056026) 1 NC_013082.1 no similarity; KLTH0F12606p 1056026 8292961 KLTH0F12606g Lachancea thermotolerans CBS 6340 KLTH0F12606p XP_002554741.1 1055736 R 559295 CDS KLTH0F12716g 255716922 8292965 1057468..1057767 1 NC_013082.1 highly similar to uniprot|P40554 YIL008W Saccharomyces cerevisiae URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin; KLTH0F12716p 1057767 8292965 KLTH0F12716g Lachancea thermotolerans CBS 6340 KLTH0F12716p XP_002554742.1 1057468 D 559295 CDS KLTH0F12738g 255716924 8292966 complement(1057808..1058530) 1 NC_013082.1 similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C; KLTH0F12738p 1058530 8292966 KLTH0F12738g Lachancea thermotolerans CBS 6340 KLTH0F12738p XP_002554743.1 1057808 R 559295 CDS KLTH0F12760g 255716926 8292967 complement(1058849..1059718) 1 NC_013082.1 similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels; KLTH0F12760p 1059718 8292967 KLTH0F12760g Lachancea thermotolerans CBS 6340 KLTH0F12760p XP_002554744.1 1058849 R 559295 CDS KLTH0F12782g 255716928 8292968 1061760..1062956 1 NC_013082.1 some similarities with uniprot|P38867 Saccharomyces cerevisiae YHR177W or some similarities with YEL007W uniprot|P40002 Saccharomyces cerevisiae; KLTH0F12782p 1062956 8292968 KLTH0F12782g Lachancea thermotolerans CBS 6340 KLTH0F12782p XP_002554745.1 1061760 D 559295 CDS KLTH0F12804g 255716930 8292969 1063271..1064413 1 NC_013082.1 similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W Pvruvate transporter of the mitochondrial inner membrane member of the mitochondrial carrier family has putative mouse and human orthologs; KLTH0F12804p 1064413 8292969 KLTH0F12804g Lachancea thermotolerans CBS 6340 KLTH0F12804p XP_002554746.1 1063271 D 559295 CDS KLTH0F12826g 255716932 8292970 1064524..1066704 1 NC_013082.1 similar to uniprot|P40557 YIL005W Saccharomyces cerevisiae EPS1 protein disulfide isomerase related protein involved in endoplasmic reticulum retention of resident ER proteins; KLTH0F12826p 1066704 8292970 KLTH0F12826g Lachancea thermotolerans CBS 6340 KLTH0F12826p XP_002554747.1 1064524 D 559295 CDS KLTH0F12848g 255716934 8292971 complement(join(1066796..1067204,1067265..1067275)) 1 NC_013082.1 similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C; KLTH0F12848p 1067275 8292971 KLTH0F12848g Lachancea thermotolerans CBS 6340 KLTH0F12848p XP_002554748.1 1066796 R 559295 CDS KLTH0F12870g 255716936 8292972 1067442..1068284 1 NC_013082.1 similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm has a potential role in assembly of iron-sulfur clusters in proteins; KLTH0F12870p 1068284 8292972 KLTH0F12870g Lachancea thermotolerans CBS 6340 KLTH0F12870p XP_002554749.1 1067442 D 559295 CDS KLTH0F12892g 255716938 8292973 complement(1068299..1069270) 1 NC_013082.1 weakly similar to uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function as suggested by its ability to bind Vac8p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F12892p 1069270 8292973 KLTH0F12892g Lachancea thermotolerans CBS 6340 KLTH0F12892p XP_002554750.1 1068299 R 559295 CDS KLTH0F12914g 255716940 8292974 1069830..1070879 1 NC_013082.1 similar to uniprot|P40004 Saccharomyces cerevisiae YEL004W; KLTH0F12914p 1070879 8292974 KLTH0F12914g Lachancea thermotolerans CBS 6340 KLTH0F12914p XP_002554751.1 1069830 D 559295 CDS KLTH0F12936g 255716942 8292975 join(1070981..1070999,1071053..1071369) 1 NC_013082.1 similar to uniprot|P40005 YEL003w Saccharomyces cerevisiae GIM4 subunit of the heterohexameric cochaperone prefoldin complex; KLTH0F12936p 1071369 8292975 KLTH0F12936g Lachancea thermotolerans CBS 6340 KLTH0F12936p XP_002554752.1 1070981 D 559295 CDS KLTH0F12958g 255716944 8292976 complement(1071465..1072784) 1 NC_013082.1 similar to uniprot|P33767 YEL002C Saccharomyces cerevisiae WBP1 wheat germ agglutinin-binding protein oligosaccharyl transferase glycoprotein complex beta subunit; KLTH0F12958p 1072784 8292976 KLTH0F12958g Lachancea thermotolerans CBS 6340 KLTH0F12958p XP_002554753.1 1071465 R 559295 CDS KLTH0F12980g 255716946 8292977 1072886..1073182 1 NC_013082.1 no similarity; KLTH0F12980p 1073182 8292977 KLTH0F12980g Lachancea thermotolerans CBS 6340 KLTH0F12980p XP_002554754.1 1072886 D 559295 CDS KLTH0F13002g 255716948 8292978 complement(1073202..1076012) 1 NC_013082.1 similar to uniprot|P40559 YIL002C Saccharomyces cerevisiae INP51 Phosphatidylinositol 4 5-bisphosphate 5- phosphataseomeostasis and in endocytosis null mutation confers cold-tolerant growth; KLTH0F13002p 1076012 8292978 KLTH0F13002g Lachancea thermotolerans CBS 6340 KLTH0F13002p XP_002554755.1 1073202 R 559295 CDS KLTH0F13024g 255716950 8292979 1076121..1077677 1 NC_013082.1 similar to uniprot|P40560 YIL001W Saccharomyces cerevisiae Hypothetical ORF; KLTH0F13024p 1077677 8292979 KLTH0F13024g Lachancea thermotolerans CBS 6340 KLTH0F13024p XP_002554756.1 1076121 D 559295 CDS KLTH0F13046g 255716952 8292980 complement(1077723..1078388) 1 NC_013082.1 similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C Hypothetical ORF; KLTH0F13046p 1078388 8292980 KLTH0F13046g Lachancea thermotolerans CBS 6340 KLTH0F13046p XP_002554757.1 1077723 R 559295 CDS KLTH0F13090g 255716954 8292982 complement(1079045..1079482) 1 NC_013082.1 some similarities with uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA- binding protein contains an RNA recognition motif (RRM) may have a role in mRNA translation as suggested by genetic interactions with genes encoding proteins involved in translational initiation; KLTH0F13090p 1079482 8292982 KLTH0F13090g Lachancea thermotolerans CBS 6340 KLTH0F13090p XP_002554758.1 1079045 R 559295 CDS KLTH0F13112g 255716956 8292983 1079721..1080404 1 NC_013082.1 similar to uniprot|P40007 YER002W Saccharomyces cerevisiae NOP16 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; KLTH0F13112p 1080404 8292983 KLTH0F13112g Lachancea thermotolerans CBS 6340 KLTH0F13112p XP_002554759.1 1079721 D 559295 CDS KLTH0F13134g 255716958 8292984 complement(join(1080516..1081774,1081837..1081867)) 1 NC_013082.1 highly similar to uniprot|P29952 YER003C Saccharomyces cerevisiae PMI40 mannose-6-phosphate isomerase; KLTH0F13134p 1081867 8292984 KLTH0F13134g Lachancea thermotolerans CBS 6340 KLTH0F13134p XP_002554760.1 1080516 R 559295 CDS KLTH0F13156g 255716960 8292985 1081997..1082608 1 NC_013082.1 conserved hypothetical protein; KLTH0F13156p 1082608 8292985 KLTH0F13156g Lachancea thermotolerans CBS 6340 KLTH0F13156p XP_002554761.1 1081997 D 559295 CDS KLTH0F13178g 255716962 8292986 1083011..1084987 1 NC_013082.1 similar to uniprot|P40009 YER005W Saccharomyces cerevisiae YND1 Yeast Nucleoside Diphosphatase; KLTH0F13178p 1084987 8292986 KLTH0F13178g Lachancea thermotolerans CBS 6340 KLTH0F13178p XP_002554762.1 1083011 D 559295 CDS KLTH0F13200g 255716964 8292987 complement(1085074..1086153) 1 NC_013082.1 highly similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; KLTH0F13200p 1086153 8292987 KLTH0F13200g Lachancea thermotolerans CBS 6340 KLTH0F13200p XP_002554763.1 1085074 R 559295 CDS KLTH0F13222g 255716966 8292988 1086482..1088044 1 NC_013082.1 similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre- ribosomes required for export of 60S ribosomal subunits from the nucleus; KLTH0F13222p 1088044 8292988 KLTH0F13222g Lachancea thermotolerans CBS 6340 KLTH0F13222p XP_002554764.1 1086482 D 559295 CDS KLTH0F13244g 255716968 8292989 1088243..1089742 1 NC_013082.1 weakly similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation binds alpha-tubulin required for normal microtubule function null mutant exhibits cold- sensitive microtubules and sensitivity to benomyl; KLTH0F13244p 1089742 8292989 KLTH0F13244g Lachancea thermotolerans CBS 6340 KLTH0F13244p XP_002554765.1 1088243 D 559295 CDS KLTH0F13266g 255716970 8292990 complement(join(1089780..1090305,1090378..1090388)) 1 NC_013082.1 similar to uniprot|P89886 YER007C-A Saccharomyces cerevisiae TMA20 Protein of unknown function that associates with ribosomes; KLTH0F13266p 1090388 8292990 KLTH0F13266g Lachancea thermotolerans CBS 6340 KLTH0F13266p XP_002554766.1 1089780 R 559295 CDS KLTH0F13310g 255716972 8293294 complement(1090990..1094076) 1 NC_013082.1 similar to uniprot|P40562 YIR002C Saccharomyces cerevisiae MPH1 Member of the DEAH family of helicases; KLTH0F13310p 1094076 8293294 KLTH0F13310g Lachancea thermotolerans CBS 6340 KLTH0F13310p XP_002554767.1 1090990 R 559295 CDS KLTH0F13332g 255716974 8292992 complement(1094317..1098186) 1 NC_013082.1 similar to uniprot|P33332 YER008C Saccharomyces cerevisiae SEC3 Non-essential subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p Exo84p); KLTH0F13332p 1098186 8292992 KLTH0F13332g Lachancea thermotolerans CBS 6340 KLTH0F13332p XP_002554768.1 1094317 R 559295 CDS KLTH0F13354g 255716976 8292993 1098462..1098839 1 NC_013082.1 highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport; KLTH0F13354p 1098839 8292993 KLTH0F13354g Lachancea thermotolerans CBS 6340 KLTH0F13354p XP_002554769.1 1098462 D 559295 CDS KLTH0F13376g 255716978 8292994 1099393..1101345 1 NC_013082.1 weakly similar to uniprot|P40563 Saccharomyces cerevisiae YIR003W Hypothetical ORF; KLTH0F13376p 1101345 8292994 KLTH0F13376g Lachancea thermotolerans CBS 6340 KLTH0F13376p XP_002554770.1 1099393 D 559295 CDS KLTH0F13398g 255716980 8292995 1101625..1102884 1 NC_013082.1 similar to uniprot|P40564 YIR004W Saccharomyces cerevisiae DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import; KLTH0F13398p 1102884 8292995 KLTH0F13398g Lachancea thermotolerans CBS 6340 KLTH0F13398p XP_002554771.1 1101625 D 559295 CDS KLTH0F13420g 255716982 8292996 complement(1102968..1103675) 1 NC_013082.1 similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Hypothetical ORF; KLTH0F13420p 1103675 8292996 KLTH0F13420g Lachancea thermotolerans CBS 6340 KLTH0F13420p XP_002554772.1 1102968 R 559295 CDS KLTH0F13442g 255716984 8292997 1103806..1104210 1 NC_013082.1 similar to uniprot|P40565 YIR005W Saccharomyces cerevisiae IST3 Component of the U2 snRNP required for the first catalytic step of splicing and for spliceosomal assembly; KLTH0F13442p 1104210 8292997 KLTH0F13442g Lachancea thermotolerans CBS 6340 KLTH0F13442p XP_002554773.1 1103806 D 559295 CDS KLTH0F13464g 255716986 8292998 complement(1104307..1108425) 1 NC_013082.1 some similarities with uniprot|P32521 YIR006C Saccharomyces cerevisiae PAN1 Part of actin cytoskeleton- regulatory complex Pan1p-Sla1p-End3p; KLTH0F13464p 1108425 8292998 KLTH0F13464g Lachancea thermotolerans CBS 6340 KLTH0F13464p XP_002554774.1 1104307 R 559295 CDS KLTH0F13486g 255716988 8292999 complement(1108786..1110657) 1 NC_013082.1 weakly similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1 3-mannosyltransferase adds the fourth and fifth alpha-1 3-linked mannose residues to O-linked glycans during protein O-glycosylation; KLTH0F13486p 1110657 8292999 KLTH0F13486g Lachancea thermotolerans CBS 6340 KLTH0F13486p XP_002554775.1 1108786 R 559295 CDS KLTH0F13530g 255716990 8293001 1111950..1112708 1 NC_013082.1 weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism; KLTH0F13530p 1112708 8293001 KLTH0F13530g Lachancea thermotolerans CBS 6340 KLTH0F13530p XP_002554776.1 1111950 D 559295 CDS KLTH0F13552g 255716992 8293002 complement(1113071..1115326) 1 NC_013082.1 weakly similar to uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate; KLTH0F13552p 1115326 8293002 KLTH0F13552g Lachancea thermotolerans CBS 6340 KLTH0F13552p XP_002554777.1 1113071 R 559295 CDS KLTH0F13574g 255716994 8293003 complement(join(1116049..1116778,1116859..1116893)) 1 NC_013082.1 highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit; KLTH0F13574p 1116893 8293003 KLTH0F13574g Lachancea thermotolerans CBS 6340 KLTH0F13574p XP_002554778.1 1116049 R 559295 CDS KLTH0F13596g 255716996 8293004 1117713..1118141 1 NC_013082.1 similar to uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta- barrel proteins also proposed to be involved in mitochondrial import; KLTH0F13596p 1118141 8293004 KLTH0F13596g Lachancea thermotolerans CBS 6340 KLTH0F13596p XP_002554779.1 1117713 D 559295 CDS KLTH0F13618g 255716998 8293005 complement(1118210..1118662) 1 NC_013082.1 similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits; KLTH0F13618p 1118662 8293005 KLTH0F13618g Lachancea thermotolerans CBS 6340 KLTH0F13618p XP_002554780.1 1118210 R 559295 CDS KLTH0F13640g 255717000 8293006 complement(1118755..1119390) 1 NC_013082.1 some similarities with uniprot|P40570 Saccharomyces cerevisiae YIR014W Hypothetical ORF; KLTH0F13640p 1119390 8293006 KLTH0F13640g Lachancea thermotolerans CBS 6340 KLTH0F13640p XP_002554781.1 1118755 R 559295 CDS KLTH0F13662g 255717002 8293007 1119926..1121587 1 NC_013082.1 some similarities with uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology; KLTH0F13662p 1121587 8293007 KLTH0F13662g Lachancea thermotolerans CBS 6340 KLTH0F13662p XP_002554782.1 1119926 D 559295 CDS KLTH0F13706g 255717004 8293009 1122321..1124555 1 NC_013082.1 similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Hypothetical ORF; KLTH0F13706p 1124555 8293009 KLTH0F13706g Lachancea thermotolerans CBS 6340 KLTH0F13706p XP_002554783.1 1122321 D 559295 CDS KLTH0F13728g 255717006 8293010 complement(1124633..1125886) 1 NC_013082.1 highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair; KLTH0F13728p 1125886 8293010 KLTH0F13728g Lachancea thermotolerans CBS 6340 KLTH0F13728p XP_002554784.1 1124633 R 559295 CDS KLTH0F13750g 255717008 8293011 1126220..1126807 1 NC_013082.1 highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle; KLTH0F13750p 1126807 8293011 KLTH0F13750g Lachancea thermotolerans CBS 6340 KLTH0F13750p XP_002554785.1 1126220 D 559295 CDS KLTH0F13772g 255717010 8293012 1130237..1133581 1 NC_013082.1 similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP- dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing; KLTH0F13772p 1133581 8293012 KLTH0F13772g Lachancea thermotolerans CBS 6340 KLTH0F13772p XP_002554786.1 1130237 D 559295 CDS KLTH0F13794g 255717012 8293013 1133687..1135282 1 NC_013082.1 similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX; KLTH0F13794p 1135282 8293013 KLTH0F13794g Lachancea thermotolerans CBS 6340 KLTH0F13794p XP_002554787.1 1133687 D 559295 CDS KLTH0F13816g 255717014 8293014 1135521..1135895 1 NC_013082.1 similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members; KLTH0F13816p 1135895 8293014 KLTH0F13816g Lachancea thermotolerans CBS 6340 KLTH0F13816p XP_002554788.1 1135521 D 559295 CDS KLTH0F13838g 255717016 8293015 1136917..1139163 1 NC_013082.1 similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids; KLTH0F13838p 1139163 8293015 KLTH0F13838g Lachancea thermotolerans CBS 6340 KLTH0F13838p XP_002554789.1 1136917 D 559295 CDS KLTH0F13860g 255717018 8293016 complement(1139221..1140351) 1 NC_013082.1 conserved hypothetical protein; KLTH0F13860p 1140351 8293016 KLTH0F13860g Lachancea thermotolerans CBS 6340 KLTH0F13860p XP_002554790.1 1139221 R 559295 CDS KLTH0F13882g 255717020 8293017 1140862..1141812 1 NC_013082.1 similar to uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; KLTH0F13882p 1141812 8293017 KLTH0F13882g Lachancea thermotolerans CBS 6340 KLTH0F13882p XP_002554791.1 1140862 D 559295 CDS KLTH0F13904g 255717022 8293018 complement(1141955..1144174) 1 NC_013082.1 similar to uniprot|P39925 Saccharomyces cerevisiae YER017C AFG3 Component with Yta12p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; KLTH0F13904p 1144174 8293018 KLTH0F13904g Lachancea thermotolerans CBS 6340 KLTH0F13904p XP_002554792.1 1141955 R 559295 CDS KLTH0F13926g 255717024 8293019 complement(1145753..1146700) 1 NC_013082.1 similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity; KLTH0F13926p 1146700 8293019 KLTH0F13926g Lachancea thermotolerans CBS 6340 KLTH0F13926p XP_002554793.1 1145753 R 559295 CDS KLTH0F13948g 255717026 8293020 1148272..1149225 1 NC_013082.1 highly similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit; KLTH0F13948p 1149225 8293020 KLTH0F13948g Lachancea thermotolerans CBS 6340 KLTH0F13948p XP_002554794.1 1148272 D 559295 CDS KLTH0F13970g 255717028 8293021 1149445..1150536 1 NC_013082.1 similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W; KLTH0F13970p 1150536 8293021 KLTH0F13970g Lachancea thermotolerans CBS 6340 KLTH0F13970p XP_002554795.1 1149445 D 559295 CDS KLTH0F13992g 255717030 8293022 1150930..1151817 1 NC_013082.1 weakly similar to uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore-microtubule attachments; KLTH0F13992p 1151817 8293022 KLTH0F13992g Lachancea thermotolerans CBS 6340 KLTH0F13992p XP_002554796.1 1150930 D 559295 CDS KLTH0F14014g 255717032 8293023 1152115..1153158 1 NC_013082.1 weakly similar to uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels; KLTH0F14014p 1153158 8293023 KLTH0F14014g Lachancea thermotolerans CBS 6340 KLTH0F14014p XP_002554797.1 1152115 D 559295 CDS KLTH0F14036g 255717034 8293024 1153469..1157836 1 NC_013082.1 similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation; KLTH0F14036p 1157836 8293024 KLTH0F14036g Lachancea thermotolerans CBS 6340 KLTH0F14036p XP_002554798.1 1153469 D 559295 CDS KLTH0F14058g 255717036 8293025 1158840..1159940 1 NC_013082.1 some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase; KLTH0F14058p 1159940 8293025 KLTH0F14058g Lachancea thermotolerans CBS 6340 KLTH0F14058p XP_002554799.1 1158840 D 559295 CDS KLTH0F14080g 255717038 8293026 1160224..1161465 1 NC_013082.1 similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W Hypothetical ORF; KLTH0F14080p 1161465 8293026 KLTH0F14080g Lachancea thermotolerans CBS 6340 KLTH0F14080p XP_002554800.1 1160224 D 559295 CDS KLTH0F14102g 255717040 8293027 complement(1161801..1162781) 1 NC_013082.1 similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation; KLTH0F14102p 1162781 8293027 KLTH0F14102g Lachancea thermotolerans CBS 6340 KLTH0F14102p XP_002554801.1 1161801 R 559295 CDS KLTH0F14124g 255717042 8293028 1163418..1164404 1 NC_013082.1 weakly similar to uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin; KLTH0F14124p 1164404 8293028 KLTH0F14124g Lachancea thermotolerans CBS 6340 KLTH0F14124p XP_002554802.1 1163418 D 559295 CDS KLTH0F14146g 255717044 8293029 complement(1164466..1165056) 1 NC_013082.1 similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; KLTH0F14146p 1165056 8293029 KLTH0F14146g Lachancea thermotolerans CBS 6340 KLTH0F14146p XP_002554803.1 1164466 R 559295 CDS KLTH0F14168g 255717046 8293030 complement(1165135..1166484) 1 NC_013082.1 weakly similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C Hypothetical ORF; KLTH0F14168p 1166484 8293030 KLTH0F14168g Lachancea thermotolerans CBS 6340 KLTH0F14168p XP_002554804.1 1165135 R 559295 CDS KLTH0F14190g 255717048 8293031 join(1167566..1167630,1167786..1168164) 1 NC_013082.1 highly similar to uniprot|P32827 Saccharomyces cerevisiae YGR118W RPS23A and to YPR132W uniprot|P32827 Saccharomyces cerevisiae YPR132W RPS23B Ribosomal proteins 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; KLTH0F14190p 1168164 8293031 KLTH0F14190g Lachancea thermotolerans CBS 6340 KLTH0F14190p XP_002554805.1 1167566 D 559295 CDS KLTH0F14212g 255717050 8293032 complement(1168436..1169539) 1 NC_013082.1 similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt- phenotype; KLTH0F14212p 1169539 8293032 KLTH0F14212g Lachancea thermotolerans CBS 6340 KLTH0F14212p XP_002554806.1 1168436 R 559295 CDS KLTH0F14234g 255717052 8293033 1169774..1169926 1 NC_013082.1 similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p; KLTH0F14234p 1169926 8293033 KLTH0F14234g Lachancea thermotolerans CBS 6340 KLTH0F14234p XP_002554807.1 1169774 D 559295 CDS KLTH0F14256g 255717054 8293034 1170380..1171219 1 NC_013082.1 conserved hypothetical protein; KLTH0F14256p 1171219 8293034 KLTH0F14256g Lachancea thermotolerans CBS 6340 KLTH0F14256p XP_002554808.1 1170380 D 559295 CDS KLTH0F14278g 255717056 8293035 complement(1171245..1172906) 1 NC_013082.1 similar to uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC) functions as the organizing center of an NPC subcomplex; KLTH0F14278p 1172906 8293035 KLTH0F14278g Lachancea thermotolerans CBS 6340 KLTH0F14278p XP_002554809.1 1171245 R 559295 CDS KLTH0F14300g 255717058 8293036 complement(1173076..1173822) 1 NC_013082.1 similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0F14300p 1173822 8293036 KLTH0F14300g Lachancea thermotolerans CBS 6340 KLTH0F14300p XP_002554810.1 1173076 R 559295 CDS KLTH0F14322g 255717060 8293037 1174310..1177012 1 NC_013082.1 similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion; KLTH0F14322p 1177012 8293037 KLTH0F14322g Lachancea thermotolerans CBS 6340 KLTH0F14322p XP_002554811.1 1174310 D 559295 CDS KLTH0F14344g 255717062 8293038 1177844..1179556 1 NC_013082.1 highly similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Rrp9p is an ortholog of the human U3-55k protein the human cDNA partially complements a yeast rrp9 null mutant. (Pluk et al. (1998) Mol. Cell. Biol. 18 488-498.) U3 small nucleolar ribonucleoprotein-associated protein involved in pre-ribosomal RNA processing.; KLTH0F14344p 1179556 8293038 KLTH0F14344g Lachancea thermotolerans CBS 6340 KLTH0F14344p XP_002554812.1 1177844 D 559295 CDS KLTH0F14410g 255717064 8293041 complement(1181896..1183257) 1 NC_013082.1 highly similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1; KLTH0F14410p 1183257 8293041 KLTH0F14410g Lachancea thermotolerans CBS 6340 KLTH0F14410p XP_002554813.1 1181896 R 559295 CDS KLTH0F14432g 255717066 8293042 1184777..1186012 1 NC_013082.1 weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W Hypothetical ORF; KLTH0F14432p 1186012 8293042 KLTH0F14432g Lachancea thermotolerans CBS 6340 KLTH0F14432p XP_002554814.1 1184777 D 559295 CDS KLTH0F14454g 255717068 8293043 complement(1186029..1186961) 1 NC_013082.1 similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66; KLTH0F14454p 1186961 8293043 KLTH0F14454g Lachancea thermotolerans CBS 6340 KLTH0F14454p XP_002554815.1 1186029 R 559295 CDS KLTH0F14476g 255717070 8293044 1187087..1188283 1 NC_013082.1 similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W; KLTH0F14476p 1188283 8293044 KLTH0F14476g Lachancea thermotolerans CBS 6340 KLTH0F14476p XP_002554816.1 1187087 D 559295 CDS KLTH0F14498g 255717072 8293045 complement(1188459..1190567) 1 NC_013082.1 similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate; KLTH0F14498p 1190567 8293045 KLTH0F14498g Lachancea thermotolerans CBS 6340 KLTH0F14498p XP_002554817.1 1188459 R 559295 CDS KLTH0F14520g 255717074 8293046 1190898..1191647 1 NC_013082.1 some similarities with uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre- rRNA processing; KLTH0F14520p 1191647 8293046 KLTH0F14520g Lachancea thermotolerans CBS 6340 KLTH0F14520p XP_002554818.1 1190898 D 559295 CDS KLTH0F14542g 255717076 8293047 complement(1191800..1193341) 1 NC_013082.1 highly similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C; KLTH0F14542p 1193341 8293047 KLTH0F14542g Lachancea thermotolerans CBS 6340 KLTH0F14542p XP_002554819.1 1191800 R 559295 CDS KLTH0F14586g 255717078 8293049 complement(1195172..1196773) 1 NC_013082.1 similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; KLTH0F14586p 1196773 8293049 KLTH0F14586g Lachancea thermotolerans CBS 6340 KLTH0F14586p XP_002554820.1 1195172 R 559295 CDS KLTH0F14630g 255717080 8293297 1198036..1199757 1 NC_013082.1 highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L- aspartate in the asparagine biosynthetic pathway; KLTH0F14630p 1199757 8293297 KLTH0F14630g Lachancea thermotolerans CBS 6340 KLTH0F14630p XP_002554821.1 1198036 D 559295 CDS KLTH0F14652g 255717082 8293051 complement(1200124..1200555) 1 NC_013082.1 no similarity; KLTH0F14652p 1200555 8293051 KLTH0F14652g Lachancea thermotolerans CBS 6340 KLTH0F14652p XP_002554822.1 1200124 R 559295 CDS KLTH0F14674g 255717084 8293052 1201874..1204906 1 NC_013082.1 similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Hypothetical ORF; KLTH0F14674p 1204906 8293052 KLTH0F14674g Lachancea thermotolerans CBS 6340 KLTH0F14674p XP_002554823.1 1201874 D 559295 CDS KLTH0F14696g 255717086 8293053 1205320..1205979 1 NC_013082.1 weakly similar to uniprot|P53274 Saccharomyces cerevisiae YGR126W Hypothetical ORF; KLTH0F14696p 1205979 8293053 KLTH0F14696g Lachancea thermotolerans CBS 6340 KLTH0F14696p XP_002554824.1 1205320 D 559295 CDS KLTH0F14718g 255717088 8293054 1207203..1208105 1 NC_013082.1 similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Hypothetical ORF; KLTH0F14718p 1208105 8293054 KLTH0F14718g Lachancea thermotolerans CBS 6340 KLTH0F14718p XP_002554825.1 1207203 D 559295 CDS KLTH0F14740g 255717090 8293055 complement(1208120..1209028) 1 NC_013082.1 similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147C Hypothetical ORF; KLTH0F14740p 1209028 8293055 KLTH0F14740g Lachancea thermotolerans CBS 6340 KLTH0F14740p XP_002554826.1 1208120 R 559295 CDS KLTH0F14762g 255717092 8293056 complement(1209571..1211523) 1 NC_013082.1 similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0F14762p 1211523 8293056 KLTH0F14762g Lachancea thermotolerans CBS 6340 KLTH0F14762p XP_002554827.1 1209571 R 559295 CDS KLTH0F14784g 255717094 8293057 1211778..1212365 1 NC_013082.1 weakly similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 SYnthetic lethal with cdcForty (putative) involved in pre-mRNA splicing; KLTH0F14784p 1212365 8293057 KLTH0F14784g Lachancea thermotolerans CBS 6340 KLTH0F14784p XP_002554828.1 1211778 D 559295 CDS KLTH0F14806g 255717096 8293058 complement(1212362..1213438) 1 NC_013082.1 similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; KLTH0F14806p 1213438 8293058 KLTH0F14806g Lachancea thermotolerans CBS 6340 KLTH0F14806p XP_002554829.1 1212362 R 559295 CDS KLTH0F14828g 255717098 8293059 complement(1213675..1216185) 1 NC_013082.1 weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F14828p 1216185 8293059 KLTH0F14828g Lachancea thermotolerans CBS 6340 KLTH0F14828p XP_002554830.1 1213675 R 559295 CDS KLTH0F14850g 255717100 8293060 1217267..1217782 1 NC_013082.1 similar to uniprot|Q12207 Saccharomyces cerevisiae YPR149W NCE102 and to uniprot|P53279 Saccharomyces cerevisiae YGR131W; KLTH0F14850p 1217782 8293060 KLTH0F14850g Lachancea thermotolerans CBS 6340 KLTH0F14850p XP_002554831.1 1217267 D 559295 CDS KLTH0F14872g 255717102 8293061 complement(1218390..1219232) 1 NC_013082.1 highly similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C; KLTH0F14872p 1219232 8293061 KLTH0F14872g Lachancea thermotolerans CBS 6340 KLTH0F14872p XP_002554832.1 1218390 R 559295 CDS KLTH0F14894g 255717104 8293062 1219767..1220267 1 NC_013082.1 similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Involved in peroxisome biogenesis Member of ubiquitin-conjugating protein family; KLTH0F14894p 1220267 8293062 KLTH0F14894g Lachancea thermotolerans CBS 6340 KLTH0F14894p XP_002554833.1 1219767 D 559295 CDS KLTH0F14916g 255717106 8293063 1220286..1220741 1 NC_013082.1 weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro; KLTH0F14916p 1220741 8293063 KLTH0F14916g Lachancea thermotolerans CBS 6340 KLTH0F14916p XP_002554834.1 1220286 D 559295 CDS KLTH0F14938g 255717108 8293064 complement(1220898..1221587) 1 NC_013082.1 weakly similar to uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c; KLTH0F14938p 1221587 8293064 KLTH0F14938g Lachancea thermotolerans CBS 6340 KLTH0F14938p XP_002554835.1 1220898 R 559295 CDS KLTH0F14960g 255717110 8293065 1222278..1224605 1 NC_013082.1 similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling component of chromatin- remodeling enzyme complexes; KLTH0F14960p 1224605 8293065 KLTH0F14960g Lachancea thermotolerans CBS 6340 KLTH0F14960p XP_002554836.1 1222278 D 559295 CDS KLTH0F14982g 255717112 8293066 complement(1224825..1227311) 1 NC_013082.1 some similarities with uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein required for normal cell surface assembly and flocculence; KLTH0F14982p 1227311 8293066 KLTH0F14982g Lachancea thermotolerans CBS 6340 KLTH0F14982p XP_002554837.1 1224825 R 559295 CDS KLTH0F15004g 255717114 8293067 1228654..1230447 1 NC_013082.1 weakly similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1; KLTH0F15004p 1230447 8293067 KLTH0F15004g Lachancea thermotolerans CBS 6340 KLTH0F15004p XP_002554838.1 1228654 D 559295 CDS KLTH0F15026g 255717116 8293068 1230760..1232484 1 NC_013082.1 similar to uniprot|Q12212 Saccharomyces cerevisiae YOR137C SIA1 Suppressor of eIF5A High-copy suppressor of temperature-sensitive tif51A-1; KLTH0F15026p 1232484 8293068 KLTH0F15026g Lachancea thermotolerans CBS 6340 KLTH0F15026p XP_002554839.1 1230760 D 559295 CDS KLTH0F15048g 255717118 8293069 complement(1232566..1233672) 1 NC_013082.1 highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; KLTH0F15048p 1233672 8293069 KLTH0F15048g Lachancea thermotolerans CBS 6340 KLTH0F15048p XP_002554840.1 1232566 R 559295 CDS KLTH0F15070g 255717120 8293070 1234917..1236713 1 NC_013082.1 similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability; KLTH0F15070p 1236713 8293070 KLTH0F15070g Lachancea thermotolerans CBS 6340 KLTH0F15070p XP_002554841.1 1234917 D 559295 CDS KLTH0F15092g 255717122 8293071 complement(1236766..1238529) 1 NC_013082.1 similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W SAC7 GTPase activating protein (GAP); KLTH0F15092p 1238529 8293071 KLTH0F15092g Lachancea thermotolerans CBS 6340 KLTH0F15092p XP_002554842.1 1236766 R 559295 CDS KLTH0F15114g 255717124 8293072 complement(1238921..1240228) 1 NC_013082.1 some similarities with uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress; KLTH0F15114p 1240228 8293072 KLTH0F15114g Lachancea thermotolerans CBS 6340 KLTH0F15114p XP_002554843.1 1238921 R 559295 CDS KLTH0F15136g 255717126 8293073 1240733..1242346 1 NC_013082.1 similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Putative transporter protein; KLTH0F15136p 1242346 8293073 KLTH0F15136g Lachancea thermotolerans CBS 6340 KLTH0F15136p XP_002554844.1 1240733 D 559295 CDS KLTH0F15158g 255717128 8293074 complement(1242367..1244217) 1 NC_013082.1 similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Helix-hairpin-helix protein involved in DNA repair and replication fork stability functions as an endonuclease in complex with Mms4p interacts with Rad54p; KLTH0F15158p 1244217 8293074 KLTH0F15158g Lachancea thermotolerans CBS 6340 KLTH0F15158p XP_002554845.1 1242367 R 559295 CDS KLTH0F15180g 255717130 8293075 complement(1244579..1247107) 1 NC_013082.1 highly similar to uniprot|P32324 Saccharomyces cerevisiae YOR133W EFT1 Elongation factor 2 (EF-2) and highly similar to uniprot|P32324 Saccharomyces cerevisiae YDR385W EFT2; KLTH0F15180p 1247107 8293075 KLTH0F15180g Lachancea thermotolerans CBS 6340 KLTH0F15180p XP_002554846.1 1244579 R 559295 CDS KLTH0F15202g 255717132 8293076 complement(1247894..1249558) 1 NC_013082.1 similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Peripheral membrane protein required for vacuolar protein sorting; KLTH0F15202p 1249558 8293076 KLTH0F15202g Lachancea thermotolerans CBS 6340 KLTH0F15202p XP_002554847.1 1247894 R 559295 CDS KLTH0F15224g 255717134 8293077 join(1249748..1249856,1249927..1250486) 1 NC_013082.1 similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Hypothetical ORF; KLTH0F15224p 1250486 8293077 KLTH0F15224g Lachancea thermotolerans CBS 6340 KLTH0F15224p XP_002554848.1 1249748 D 559295 CDS KLTH0F15246g 255717136 8293078 1250815..1251579 1 NC_013082.1 no similarity; KLTH0F15246p 1251579 8293078 KLTH0F15246g Lachancea thermotolerans CBS 6340 KLTH0F15246p XP_002554849.1 1250815 D 559295 CDS KLTH0F15268g 255717138 8293079 1251729..1252580 1 NC_013082.1 similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters; KLTH0F15268p 1252580 8293079 KLTH0F15268g Lachancea thermotolerans CBS 6340 KLTH0F15268p XP_002554850.1 1251729 D 559295 CDS KLTH0F15334g 255717140 8293082 complement(1253915..1254187) 1 NC_013082.1 conserved hypothetical protein; KLTH0F15334p 1254187 8293082 KLTH0F15334g Lachancea thermotolerans CBS 6340 KLTH0F15334p XP_002554851.1 1253915 R 559295 CDS KLTH0F15356g 255717142 8293083 1255533..1256276 1 NC_013082.1 weakly similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C NKP1; KLTH0F15356p 1256276 8293083 KLTH0F15356g Lachancea thermotolerans CBS 6340 KLTH0F15356p XP_002554852.1 1255533 D 559295 CDS KLTH0F15378g 255717144 8293084 complement(1256318..1256650) 1 NC_013082.1 similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm; KLTH0F15378p 1256650 8293084 KLTH0F15378g Lachancea thermotolerans CBS 6340 KLTH0F15378p XP_002554853.1 1256318 R 559295 CDS KLTH0F15400g 255717146 8293085 1257203..1258039 1 NC_013082.1 similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane exports ornithine from mitochondria as part of arginine biosynthesis human ortholog is associated with hyperammonaemia- hyperornithinaemia-homocitrullinuria (HHH) syndrome; KLTH0F15400p 1258039 8293085 KLTH0F15400g Lachancea thermotolerans CBS 6340 KLTH0F15400p XP_002554854.1 1257203 D 559295 CDS KLTH0F15422g 255717148 8293086 complement(1258131..1259156) 1 NC_013082.1 weakly similar to uniprot|P39953 Saccharomyces cerevisiae YEL006W Hypothetical ORF; KLTH0F15422p 1259156 8293086 KLTH0F15422g Lachancea thermotolerans CBS 6340 KLTH0F15422p XP_002554855.1 1258131 R 559295 CDS KLTH0F15444g 255717150 8293087 join(1259731..1259762,1259839..1260121) 1 NC_013082.1 KLTH0F15444p 1260121 8293087 KLTH0F15444g Lachancea thermotolerans CBS 6340 KLTH0F15444p XP_002554856.1 1259731 D 559295 CDS KLTH0F15466g 255717152 8293088 complement(join(1260382..1260771,1261466..1261717)) 1 NC_013082.1 similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 Nuclear protein that binds to RNA and to Mex67p required for export of poly(A) mRNA from the nucleus member of the REF (RNA and export factor binding proteins) family another family member Yra2p can substitute for Yra1p function; KLTH0F15466p 1261717 8293088 KLTH0F15466g Lachancea thermotolerans CBS 6340 KLTH0F15466p XP_002554857.1 1260382 R 559295 CDS KLTH0F15488g 255717154 8293089 1262975..1265641 1 NC_013082.1 similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C Putative component of the outer plaque of the spindle pole body; may be involved in cation homeostasis or multidrug resistance; KLTH0F15488p 1265641 8293089 KLTH0F15488g Lachancea thermotolerans CBS 6340 KLTH0F15488p XP_002554858.1 1262975 D 559295 CDS KLTH0F15510g 255717156 8293090 complement(1265767..1267644) 1 NC_013082.1 similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde which is the first specific step in the Ehrlich pathway; KLTH0F15510p 1267644 8293090 KLTH0F15510g Lachancea thermotolerans CBS 6340 KLTH0F15510p XP_002554859.1 1265767 R 559295 CDS KLTH0F15532g 255717158 8293091 1268745..1270466 1 NC_013082.1 similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway red pigment accumulates in mutant cells deprived of adenine; KLTH0F15532p 1270466 8293091 KLTH0F15532g Lachancea thermotolerans CBS 6340 KLTH0F15532p XP_002554860.1 1268745 D 559295 CDS KLTH0F15554g 255717160 8293092 complement(1271266..1272909) 1 NC_013082.1 conserved hypothetical protein; KLTH0F15554p 1272909 8293092 KLTH0F15554g Lachancea thermotolerans CBS 6340 KLTH0F15554p XP_002554861.1 1271266 R 559295 CDS KLTH0F15576g 255717162 8293093 1274321..1274560 1 NC_013082.1 KLTH0F15576p 1274560 8293093 KLTH0F15576g Lachancea thermotolerans CBS 6340 KLTH0F15576p XP_002554862.1 1274321 D 559295 CDS KLTH0F15598g 255717164 8293094 complement(1274669..1277551) 1 NC_013082.1 weakly similar to uniprot|Q06407 Saccharomyces cerevisiae YDR379W RGA2 GTPase-activating protein for the polarity-establishment protein Cdc42p implicated in control of septin organization pheromone response and haploid invasive growth; KLTH0F15598p 1277551 8293094 KLTH0F15598g Lachancea thermotolerans CBS 6340 KLTH0F15598p XP_002554863.1 1274669 R 559295 CDS KLTH0F15620g 255717166 8293095 1278002..1278256 1 NC_013082.1 some similarities with uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; KLTH0F15620p 1278256 8293095 KLTH0F15620g Lachancea thermotolerans CBS 6340 KLTH0F15620p XP_002554864.1 1278002 D 559295 CDS KLTH0F15642g 255717168 8293096 complement(join(1278533..1278781,1278908..1278964)) 1 NC_013082.1 highly similar to uniprot|Q06405 Saccharomyces cerevisiae YDR377W ATP17 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0F15642p 1278964 8293096 KLTH0F15642g Lachancea thermotolerans CBS 6340 KLTH0F15642p XP_002554865.1 1278533 R 559295 CDS KLTH0F15664g 255717170 8293097 complement(1279273..1280745) 1 NC_013082.1 similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster- containing enzymes one of the few mitochondrial proteins essential for viability; KLTH0F15664p 1280745 8293097 KLTH0F15664g Lachancea thermotolerans CBS 6340 KLTH0F15664p XP_002554866.1 1279273 R 559295 CDS KLTH0F15686g 255717172 8293098 1281249..1281971 1 NC_013082.1 similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate which is particularly important in sake brewing; KLTH0F15686p 1281971 8293098 KLTH0F15686g Lachancea thermotolerans CBS 6340 KLTH0F15686p XP_002554867.1 1281249 D 559295 CDS KLTH0F15708g 255717174 8293099 complement(1282059..1282307) 1 NC_013082.1 no similarity; KLTH0F15708p 1282307 8293099 KLTH0F15708g Lachancea thermotolerans CBS 6340 KLTH0F15708p XP_002554868.1 1282059 R 559295 CDS KLTH0F15730g 255717176 8293100 1282421..1283773 1 NC_013082.1 highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins member of the CDC48/PAS1/SEC18 ATPase family; KLTH0F15730p 1283773 8293100 KLTH0F15730g Lachancea thermotolerans CBS 6340 KLTH0F15730p XP_002554869.1 1282421 D 559295 CDS KLTH0F15752g 255717178 8293101 1284586..1285362 1 NC_013082.1 weakly similar to uniprot|Q06390 Saccharomyces cerevisiae YDR374C Hypothetical ORF; KLTH0F15752p 1285362 8293101 KLTH0F15752g Lachancea thermotolerans CBS 6340 KLTH0F15752p XP_002554870.1 1284586 D 559295 CDS KLTH0F15774g 255717180 8293102 1285487..1286179 1 NC_013082.1 highly similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis essential for several other metabolic pathways including respiration and gluconeogenic gene activation; KLTH0F15774p 1286179 8293102 KLTH0F15774g Lachancea thermotolerans CBS 6340 KLTH0F15774p XP_002554871.1 1285487 D 559295 CDS KLTH0F15796g 255717182 8293103 complement(1286366..1286938) 1 NC_013082.1 highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4- kinase Pik1p member of the recoverin/frequenin branch of the EF-hand superfamily; KLTH0F15796p 1286938 8293103 KLTH0F15796g Lachancea thermotolerans CBS 6340 KLTH0F15796p XP_002554872.1 1286366 R 559295 CDS KLTH0F15818g 255717184 8293104 complement(1287301..1287591) 1 NC_013082.1 no similarity; KLTH0F15818p 1287591 8293104 KLTH0F15818g Lachancea thermotolerans CBS 6340 KLTH0F15818p XP_002554873.1 1287301 R 559295 CDS KLTH0F15840g 255717186 8293105 1288327..1288698 1 NC_013082.1 no similarity; KLTH0F15840p 1288698 8293105 KLTH0F15840g Lachancea thermotolerans CBS 6340 KLTH0F15840p XP_002554874.1 1288327 D 559295 CDS KLTH0F15862g 255717188 8293106 1288742..1292467 1 NC_013082.1 similar to uniprot|Q01476 Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions capable of cleaving polyubiquitin and possesses isopeptidase activity; KLTH0F15862p 1292467 8293106 KLTH0F15862g Lachancea thermotolerans CBS 6340 KLTH0F15862p XP_002554875.1 1288742 D 559295 CDS KLTH0F15884g 255717190 8293107 1292767..1293756 1 NC_013082.1 highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74; KLTH0F15884p 1293756 8293107 KLTH0F15884g Lachancea thermotolerans CBS 6340 KLTH0F15884p XP_002554876.1 1292767 D 559295 CDS KLTH0F15906g 255717192 8293108 complement(1293832..1295379) 1 NC_013082.1 similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Sporulation-specific chitinase; KLTH0F15906p 1295379 8293108 KLTH0F15906g Lachancea thermotolerans CBS 6340 KLTH0F15906p XP_002554877.1 1293832 R 559295 CDS KLTH0F15928g 255717194 8293109 1295609..1296880 1 NC_013082.1 similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex which associates with RNA polymerase II and is involved in histone methylation; KLTH0F15928p 1296880 8293109 KLTH0F15928g Lachancea thermotolerans CBS 6340 KLTH0F15928p XP_002554878.1 1295609 D 559295 CDS KLTH0F15950g 255717196 8293110 join(1297129..1297141,1297227..1297594) 1 NC_013082.1 highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin actin- and phosphatidylinositol 4 5-bisphosphate-binding protein plays a role in cytoskeleton organization required for normal timing of actin polymerization in response to thermal stress localizes to plasma membrane and cytosol; KLTH0F15950p 1297594 8293110 KLTH0F15950g Lachancea thermotolerans CBS 6340 KLTH0F15950p XP_002554879.1 1297129 D 559295 CDS KLTH0F15972g 255717198 8293111 complement(1297711..1298022) 1 NC_013082.1 conserved hypothetical protein; KLTH0F15972p 1298022 8293111 KLTH0F15972g Lachancea thermotolerans CBS 6340 KLTH0F15972p XP_002554880.1 1297711 R 559295 CDS KLTH0F15994g 255717200 8293112 1298649..1299821 1 NC_013082.1 weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Hypothetical ORF; KLTH0F15994p 1299821 8293112 KLTH0F15994g Lachancea thermotolerans CBS 6340 KLTH0F15994p XP_002554881.1 1298649 D 559295 CDS KLTH0F16016g 255717202 8293113 1299984..1301438 1 NC_013082.1 conserved hypothetical protein; KLTH0F16016p 1301438 8293113 KLTH0F16016g Lachancea thermotolerans CBS 6340 KLTH0F16016p XP_002554882.1 1299984 D 559295 CDS KLTH0F16038g 255717204 8293114 1302028..1304406 1 NC_013082.1 weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 classified as an early recombination function required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth) required for double strand breaks meiotic recombination and spore viability DNA repair protein; KLTH0F16038p 1304406 8293114 KLTH0F16038g Lachancea thermotolerans CBS 6340 KLTH0F16038p XP_002554883.1 1302028 D 559295 CDS KLTH0F16060g 255717206 8293115 complement(1304479..1305408) 1 NC_013082.1 similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism; KLTH0F16060p 1305408 8293115 KLTH0F16060g Lachancea thermotolerans CBS 6340 KLTH0F16060p XP_002554884.1 1304479 R 559295 CDS KLTH0F16082g 255717208 8293116 complement(1305673..1306293) 1 NC_013082.1 similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F16082p 1306293 8293116 KLTH0F16082g Lachancea thermotolerans CBS 6340 KLTH0F16082p XP_002554885.1 1305673 R 559295 CDS KLTH0F16104g 255717210 8293117 1306436..1308058 1 NC_013082.1 similar to uniprot|Q12196 YOR119C Saccharomyces cerevisiae RIO1 Essential protein that plays a role in cell cycle progression; KLTH0F16104p 1308058 8293117 KLTH0F16104g Lachancea thermotolerans CBS 6340 KLTH0F16104p XP_002554886.1 1306436 D 559295 CDS KLTH0F16126g 255717212 8293118 complement(1308133..1309797) 1 NC_013082.1 similar to uniprot|Q12108 YOR118W Saccharomyces cerevisiae Hypothetical ORF; KLTH0F16126p 1309797 8293118 KLTH0F16126g Lachancea thermotolerans CBS 6340 KLTH0F16126p XP_002554887.1 1308133 R 559295 CDS KLTH0F16148g 255717214 8293119 1310041..1311981 1 NC_013082.1 similar to uniprot|Q06344 YDR365C Saccharomyces cerevisiae ESF1 Nucleolar protein involved in pre-rRNA processing; KLTH0F16148p 1311981 8293119 KLTH0F16148g Lachancea thermotolerans CBS 6340 KLTH0F16148p XP_002554888.1 1310041 D 559295 CDS KLTH0F16192g 255717216 8293121 1312331..1313719 1 NC_013082.1 similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression required for DNA synthesis during mitosis and meiosis has WD repeats; KLTH0F16192p 1313719 8293121 KLTH0F16192g Lachancea thermotolerans CBS 6340 KLTH0F16192p XP_002554889.1 1312331 D 559295 CDS KLTH0F16214g 255717218 8293122 complement(1313746..1315050) 1 NC_013082.1 highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription; KLTH0F16214p 1315050 8293122 KLTH0F16214g Lachancea thermotolerans CBS 6340 KLTH0F16214p XP_002554890.1 1313746 R 559295 CDS KLTH0F16236g 255717220 8293123 1316542..1320924 1 NC_013082.1 highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C; KLTH0F16236p 1320924 8293123 KLTH0F16236g Lachancea thermotolerans CBS 6340 KLTH0F16236p XP_002554891.1 1316542 D 559295 CDS KLTH0F16280g 255717222 8293125 complement(1321305..1322726) 1 NC_013082.1 some similarities with uniprot|Q06340 YDR363W Saccharomyces cerevisiae ESC2 Protein involved in mating- type locus silencing interacts with Sir2p; KLTH0F16280p 1322726 8293125 KLTH0F16280g Lachancea thermotolerans CBS 6340 KLTH0F16280p XP_002554892.1 1321305 R 559295 CDS KLTH0F16302g 255717224 8293126 complement(1322949..1324436) 1 NC_013082.1 highly similar to uniprot|P38821 YHR113W Saccharomyces cerevisiae Hypothetical ORF; KLTH0F16302p 1324436 8293126 KLTH0F16302g Lachancea thermotolerans CBS 6340 KLTH0F16302p XP_002554893.1 1322949 R 559295 CDS KLTH0F16324g 255717226 8293127 1325151..1327202 1 NC_013082.1 similar to uniprot|Q06339 YDR362C Saccharomyces cerevisiae TFC6 one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); KLTH0F16324p 1327202 8293127 KLTH0F16324g Lachancea thermotolerans CBS 6340 KLTH0F16324p XP_002554894.1 1325151 D 559295 CDS KLTH0F16346g 255717228 8293128 complement(1327212..1328522) 1 NC_013082.1 similar to uniprot|P38820 YHR111W Saccharomyces cerevisiae UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation); KLTH0F16346p 1328522 8293128 KLTH0F16346g Lachancea thermotolerans CBS 6340 KLTH0F16346p XP_002554895.1 1327212 R 559295 CDS KLTH0F16368g 255717230 8293129 complement(1328719..1329381) 1 NC_013082.1 similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W; KLTH0F16368p 1329381 8293129 KLTH0F16368g Lachancea thermotolerans CBS 6340 KLTH0F16368p XP_002554896.1 1328719 R 559295 CDS KLTH0F16390g 255717232 8293130 complement(1329486..1331249) 1 NC_013082.1 weakly similar to uniprot|P38818 YHR109W Saccharomyces cerevisiae CTM1 Cytochrome c lysine methyltransferase; KLTH0F16390p 1331249 8293130 KLTH0F16390g Lachancea thermotolerans CBS 6340 KLTH0F16390p XP_002554897.1 1329486 R 559295 CDS KLTH0F16412g 255717234 8293131 1331568..1332368 1 NC_013082.1 similar to uniprot|Q06338 YDR361C Saccharomyces cerevisiae BCP1 Essential protein involved in nuclear export of Mss4p; KLTH0F16412p 1332368 8293131 KLTH0F16412g Lachancea thermotolerans CBS 6340 KLTH0F16412p XP_002554898.1 1331568 D 559295 CDS KLTH0F16434g 255717236 8293132 1332697..1335483 1 NC_013082.1 similar to uniprot|Q06337 YDR359C Saccharomyces cerevisiae VID21 Component of the NuA4 histone acetyltransferase complex; KLTH0F16434p 1335483 8293132 KLTH0F16434g Lachancea thermotolerans CBS 6340 KLTH0F16434p XP_002554899.1 1332697 D 559295 CDS KLTH0F16456g 255717238 8293133 complement(1335576..1337291) 1 NC_013082.1 similar to uniprot|P38817 YHR108W Saccharomyces cerevisiae GGA2 Golgi-localized protein with homology to gamma-adaptin; KLTH0F16456p 1337291 8293133 KLTH0F16456g Lachancea thermotolerans CBS 6340 KLTH0F16456p XP_002554900.1 1335576 R 559295 CDS KLTH0F16478g 255717240 8293134 1337447..1337842 1 NC_013082.1 similar to uniprot|Q06333 YDR357C Saccharomyces cerevisiae Protein of unknown function; KLTH0F16478p 1337842 8293134 KLTH0F16478g Lachancea thermotolerans CBS 6340 KLTH0F16478p XP_002554901.1 1337447 D 559295 CDS KLTH0F16500g 255717242 8293135 complement(1337865..1340381) 1 NC_013082.1 weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component ortholog of human kendrin involved in connecting nuclear microtubules to SPB interacts with Tub4p-complex and calmodulin phosphorylated by Mps1p in cell cycle-dependent manner; KLTH0F16500p 1340381 8293135 KLTH0F16500g Lachancea thermotolerans CBS 6340 KLTH0F16500p XP_002554902.1 1337865 R 559295 CDS KLTH0F16522g 255717244 8293136 complement(1340683..1341777) 1 NC_013082.1 similar to uniprot|P07285 YDR354W Saccharomyces cerevisiae TRP4 anthranilate phosphoribosyl transferase; KLTH0F16522p 1341777 8293136 KLTH0F16522g Lachancea thermotolerans CBS 6340 KLTH0F16522p XP_002554903.1 1340683 R 559295 CDS KLTH0F16544g 255717246 8293137 1342328..1343485 1 NC_013082.1 highly similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; KLTH0F16544p 1343485 8293137 KLTH0F16544g Lachancea thermotolerans CBS 6340 KLTH0F16544p XP_002554904.1 1342328 D 559295 CDS KLTH0F16566g 255717248 8293138 complement(1343643..1344665) 1 NC_013082.1 highly similar to uniprot|P29509 YDR353W Saccharomyces cerevisiae TRR1 Thioredoxin reductase; KLTH0F16566p 1344665 8293138 KLTH0F16566g Lachancea thermotolerans CBS 6340 KLTH0F16566p XP_002554905.1 1343643 R 559295 CDS KLTH0F16588g 255717250 8293139 complement(1344877..1345521) 1 NC_013082.1 weakly similar to uniprot|P38815 Saccharomyces cerevisiae YHR105W YPT35 Hypothetical ORF; KLTH0F16588p 1345521 8293139 KLTH0F16588g Lachancea thermotolerans CBS 6340 KLTH0F16588p XP_002554906.1 1344877 R 559295 CDS KLTH0F16610g 255717252 8293140 complement(1346319..1347308) 1 NC_013082.1 highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal d-xylose and arabinose metabolism stress induced (osmotic ionic oxidative heat shock starvation and heavy metals) regulated by the HOG pathway; KLTH0F16610p 1347308 8293140 KLTH0F16610g Lachancea thermotolerans CBS 6340 KLTH0F16610p XP_002554907.1 1346319 R 559295 CDS KLTH0F16632g 255717254 8293141 complement(1347661..1348548) 1 NC_013082.1 similar to uniprot|Q06328 Saccharomyces cerevisiae YDR352W Hypothetical ORF; KLTH0F16632p 1348548 8293141 KLTH0F16632g Lachancea thermotolerans CBS 6340 KLTH0F16632p XP_002554908.1 1347661 R 559295 CDS KLTH0F16654g 255717256 8293142 complement(1348727..1351048) 1 NC_013082.1 similar to uniprot|P38814 YHR103W Saccharomyces cerevisiae SBE Protein involved in the transport of cell wall components from the Golgi to the cell surface; KLTH0F16654p 1351048 8293142 KLTH0F16654g Lachancea thermotolerans CBS 6340 KLTH0F16654p XP_002554909.1 1348727 R 559295 CDS KLTH0F16676g 255717258 8293143 complement(1351362..1353998) 1 NC_013082.1 weakly similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 kinase family required for cell integrity possibly through regulating 1 6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin) which is a component of the spindle pole body; KLTH0F16676p 1353998 8293143 KLTH0F16676g Lachancea thermotolerans CBS 6340 KLTH0F16676p XP_002554910.1 1351362 R 559295 CDS KLTH0F16698g 255717260 8293144 1354232..1356262 1 NC_013082.1 weakly similar to uniprot|P50273 YDR350C Saccharomyces cerevisiae CM10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase; KLTH0F16698p 1356262 8293144 KLTH0F16698g Lachancea thermotolerans CBS 6340 KLTH0F16698p XP_002554911.1 1354232 D 559295 CDS KLTH0F16720g 255717262 8293145 join(1356384..1356481,1356547..1357411) 1 NC_013082.1 similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum required for normal content of cell wall beta-1 6-glucan; KLTH0F16720p 1357411 8293145 KLTH0F16720g Lachancea thermotolerans CBS 6340 KLTH0F16720p XP_002554912.1 1356384 D 559295 CDS KLTH0F16742g 255717264 8293146 1357590..1358402 1 NC_013082.1 similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic endocytic and retrograde traffic into the prevacuolar compartment syntaxin; KLTH0F16742p 1358402 8293146 KLTH0F16742g Lachancea thermotolerans CBS 6340 KLTH0F16742p XP_002554913.1 1357590 D 559295 CDS KLTH0F16764g 255717266 8293147 complement(1358483..1359478) 1 NC_013082.1 similar to uniprot|Q05583 YDR267C Saccharomyces cerevisiae CIA1 Protein required for cell viability; KLTH0F16764p 1359478 8293147 KLTH0F16764g Lachancea thermotolerans CBS 6340 KLTH0F16764p XP_002554914.1 1358483 R 559295 CDS KLTH0F16786g 255717268 8293148 1359602..1360645 1 NC_013082.1 weakly similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p) potential Cdc28p substrate; KLTH0F16786p 1360645 8293148 KLTH0F16786g Lachancea thermotolerans CBS 6340 KLTH0F16786p XP_002554915.1 1359602 D 559295 CDS KLTH0F16808g 255717270 8293149 1360799..1361917 1 NC_013082.1 similar to uniprot|P04803 YDR268W Saccharomyces cerevisiae MSW1 Mitochondrial tryptophanyl-tRNA synthetase; KLTH0F16808p 1361917 8293149 KLTH0F16808g Lachancea thermotolerans CBS 6340 KLTH0F16808p XP_002554916.1 1360799 D 559295 CDS KLTH0F16830g 255717272 8293150 complement(1361983..1364532) 1 NC_013082.1 similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p; KLTH0F16830p 1364532 8293150 KLTH0F16830g Lachancea thermotolerans CBS 6340 KLTH0F16830p XP_002554917.1 1361983 R 559295 CDS KLTH0F16852g 255717274 8293151 1364656..1365381 1 NC_013082.1 similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 protein kinase CK2 beta' subunit; KLTH0F16852p 1365381 8293151 KLTH0F16852g Lachancea thermotolerans CBS 6340 KLTH0F16852p XP_002554918.1 1364656 D 559295 CDS KLTH0F16874g 255717276 8293152 1365921..1368887 1 NC_013082.1 similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W; KLTH0F16874p 1368887 8293152 KLTH0F16874g Lachancea thermotolerans CBS 6340 KLTH0F16874p XP_002554919.1 1365921 D 559295 CDS KLTH0F16896g 255717278 8293153 1369090..1369944 1 NC_013082.1 similar to uniprot|Q12320 Saccharomyces cerevisiae YOR040W GLO4 Mitochondrial glyoxalase II catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; KLTH0F16896p 1369944 8293153 KLTH0F16896g Lachancea thermotolerans CBS 6340 KLTH0F16896p XP_002554920.1 1369090 D 559295 CDS KLTH0F16918g 255717280 8293154 1371147..1372514 1 NC_013082.1 weakly similar to uniprot|Q08412 Saccharomyces cerevisiae YOR042W CUE5 Protein containing a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F16918p 1372514 8293154 KLTH0F16918g Lachancea thermotolerans CBS 6340 KLTH0F16918p XP_002554921.1 1371147 D 559295 CDS KLTH0F16962g 255717282 8293299 complement(1373279..1374778) 1 NC_013082.1 conserved hypothetical protein; KLTH0F16962p 1374778 8293299 KLTH0F16962g Lachancea thermotolerans CBS 6340 KLTH0F16962p XP_002554922.1 1373279 R 559295 CDS KLTH0F16984g 255717284 8293156 1376160..1377497 1 NC_013082.1 similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required with binding partner Psr1p for full activation of the general stress response possibly through Msn2p dephosphorylation regulates growth during the diauxic shift negative regulator of G1 cyclin expression; KLTH0F16984p 1377497 8293156 KLTH0F16984g Lachancea thermotolerans CBS 6340 KLTH0F16984p XP_002554923.1 1376160 D 559295 CDS KLTH0F17006g 255717286 8293157 1378063..1378608 1 NC_013082.1 conserved hypothetical protein; KLTH0F17006p 1378608 8293157 KLTH0F17006g Lachancea thermotolerans CBS 6340 KLTH0F17006p XP_002554924.1 1378063 D 559295 CDS KLTH0F17028g 255717288 8293158 1379075..1379248 1 NC_013082.1 similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components; outer mitochondrial membrane protein, component of the mitochondiral protein translocation complex, associates with TOM40; KLTH0F17028p 1379248 8293158 KLTH0F17028g Lachancea thermotolerans CBS 6340 KLTH0F17028p XP_002554925.1 1379075 D 559295 CDS KLTH0F17050g 255717290 8293159 complement(join(1380459..1381888,1381971..1381977)) 1 NC_013082.1 highly similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; KLTH0F17050p 1381977 8293159 KLTH0F17050g Lachancea thermotolerans CBS 6340 KLTH0F17050p XP_002554926.1 1380459 R 559295 CDS KLTH0F17072g 255717292 8293160 complement(1382266..1383444) 1 NC_013082.1 similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C MTH1 Negative regulator of the glucose- sensing signal transduction pathway required for repression of transcription by Rgt1p interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors phosphorylated by Yck1p triggering Mth1p degradation; KLTH0F17072p 1383444 8293160 KLTH0F17072g Lachancea thermotolerans CBS 6340 KLTH0F17072p XP_002554927.1 1382266 R 559295 CDS KLTH0F17116g 255717294 8293162 complement(1385113..1388061) 1 NC_013082.1 similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease involved in RNA metabolism including rRNA and snRNA processing as well as mRNA transcription termination; KLTH0F17116p 1388061 8293162 KLTH0F17116g Lachancea thermotolerans CBS 6340 KLTH0F17116p XP_002554928.1 1385113 R 559295 CDS KLTH0F17138g 255717296 8293163 complement(1388784..1389896) 1 NC_013082.1 similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane; KLTH0F17138p 1389896 8293163 KLTH0F17138g Lachancea thermotolerans CBS 6340 KLTH0F17138p XP_002554929.1 1388784 R 559295 CDS KLTH0F17160g 255717298 8293164 1391428..1393518 1 NC_013082.1 similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone which are intermediate steps in lipid biosynthesis; KLTH0F17160p 1393518 8293164 KLTH0F17160g Lachancea thermotolerans CBS 6340 KLTH0F17160p XP_002554930.1 1391428 D 559295 CDS KLTH0F17182g 255717300 8293165 complement(1393596..1394204) 1 NC_013082.1 highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles component of the TRAPP (transport protein particle) complex; KLTH0F17182p 1394204 8293165 KLTH0F17182g Lachancea thermotolerans CBS 6340 KLTH0F17182p XP_002554931.1 1393596 R 559295 CDS KLTH0F17204g 255717302 8293166 complement(1394343..1395614) 1 NC_013082.1 similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; KLTH0F17204p 1395614 8293166 KLTH0F17204g Lachancea thermotolerans CBS 6340 KLTH0F17204p XP_002554932.1 1394343 R 559295 CDS KLTH0F17226g 255717304 8293167 1396152..1397945 1 NC_013082.1 similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase; KLTH0F17226p 1397945 8293167 KLTH0F17226g Lachancea thermotolerans CBS 6340 KLTH0F17226p XP_002554933.1 1396152 D 559295 CDS KLTH0F17248g 255717306 8293168 1398052..1399140 1 NC_013082.1 similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF; KLTH0F17248p 1399140 8293168 KLTH0F17248g Lachancea thermotolerans CBS 6340 KLTH0F17248p XP_002554934.1 1398052 D 559295 CDS KLTH0F17270g 255717308 8293169 complement(1399219..1399563) 1 NC_013082.1 some similarities with uniprot|O00017 Saccharomyces cerevisiae YOR052C; KLTH0F17270p 1399563 8293169 KLTH0F17270g Lachancea thermotolerans CBS 6340 KLTH0F17270p XP_002554935.1 1399219 R 559295 CDS KLTH0F17292g 255717310 8293170 complement(1400559..1401605) 1 NC_013082.1 similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2; KLTH0F17292p 1401605 8293170 KLTH0F17292g Lachancea thermotolerans CBS 6340 KLTH0F17292p XP_002554936.1 1400559 R 559295 CDS KLTH0F17314g 255717312 8293171 complement(1401871..1403847) 1 NC_013082.1 weakly similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C VHS3 Regulatory subunit of Ppz1p which is an isoform of serine/threonine protein phosphatase Z involved in regulation of potassium transport overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation; KLTH0F17314p 1403847 8293171 KLTH0F17314g Lachancea thermotolerans CBS 6340 KLTH0F17314p XP_002554937.1 1401871 R 559295 CDS KLTH0F17336g 255717314 8293172 complement(1404139..1405536) 1 NC_013082.1 similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Nin1 (One) Binding protein essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosome subunits required for cleavage of the 20S pre- rRNA to generate the mature 18S rRNA.; KLTH0F17336p 1405536 8293172 KLTH0F17336g Lachancea thermotolerans CBS 6340 KLTH0F17336p XP_002554938.1 1404139 R 559295 CDS KLTH0F17358g 255717316 8293173 1405913..1407055 1 NC_013082.1 similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Probable cochaperone regulates activity of Cyr1p (adenylyl cyclase) involved in assembly of the kinetochore complex associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; KLTH0F17358p 1407055 8293173 KLTH0F17358g Lachancea thermotolerans CBS 6340 KLTH0F17358p XP_002554939.1 1405913 D 559295 CDS KLTH0F17380g 255717318 8293174 complement(1407169..1409892) 1 NC_013082.1 similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Member of a family of microtubule- associated proteins (MAPs) that function at the mitotic spindle midzone required for spindle elongation undergoes cell cycle-regulated degradation by anaphase promoting complex potential Cdc28p substrate; KLTH0F17380p 1409892 8293174 KLTH0F17380g Lachancea thermotolerans CBS 6340 KLTH0F17380p XP_002554940.1 1407169 R 559295 CDS KLTH0F17424g 255717320 8293176 join(1410615..1410672,1410744..1411132) 1 NC_013082.1 similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W Hypothetical ORF; KLTH0F17424p 1411132 8293176 KLTH0F17424g Lachancea thermotolerans CBS 6340 KLTH0F17424p XP_002554941.1 1410615 D 559295 CDS KLTH0F17446g 255717322 8293177 complement(1411332..1412657) 1 NC_013082.1 similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF; KLTH0F17446p 1412657 8293177 KLTH0F17446g Lachancea thermotolerans CBS 6340 KLTH0F17446p XP_002554942.1 1411332 R 559295 CDS KLTH0F17468g 255717324 8293178 complement(1412804..1413529) 1 NC_013082.1 similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C Protein required for cell viability; KLTH0F17468p 1413529 8293178 KLTH0F17468g Lachancea thermotolerans CBS 6340 KLTH0F17468p XP_002554943.1 1412804 R 559295 CDS KLTH0F17490g 255717326 8293179 1413752..1414774 1 NC_013082.1 highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 may have a role in regulation and/or execution of the eukaryotic cell cycle alpha' subunit of casein kinase II; KLTH0F17490p 1414774 8293179 KLTH0F17490g Lachancea thermotolerans CBS 6340 KLTH0F17490p XP_002554944.1 1413752 D 559295 CDS KLTH0F17512g 255717328 8293180 complement(1415008..1415817) 1 NC_013082.1 weakly similar to uniprot|P36025 Saccharomyces cerevisiae YOR062C; KLTH0F17512p 1415817 8293180 KLTH0F17512g Lachancea thermotolerans CBS 6340 KLTH0F17512p XP_002554945.1 1415008 R 559295 CDS KLTH0F17534g 255717330 8293181 complement(1416064..1416708) 1 NC_013082.1 no similarity; KLTH0F17534p 1416708 8293181 KLTH0F17534g Lachancea thermotolerans CBS 6340 KLTH0F17534p XP_002554946.1 1416064 R 559295 CDS KLTH0F17556g 255717332 8293182 1416942..1418108 1 NC_013082.1 highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W; KLTH0F17556p 1418108 8293182 KLTH0F17556g Lachancea thermotolerans CBS 6340 KLTH0F17556p XP_002554947.1 1416942 D 559295 CDS KLTH0F17578g 255717334 8293183 complement(1418298..1418861) 1 NC_013082.1 weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Yeast homolog of mammalian Ing1; histone acetyltransferase complex component; KLTH0F17578p 1418861 8293183 KLTH0F17578g Lachancea thermotolerans CBS 6340 KLTH0F17578p XP_002554948.1 1418298 R 559295 CDS KLTH0F17600g 255717336 8293184 join(1419964..1420005,1420158..1421027) 1 NC_013082.1 similar to uniprot|P07143 Saccharomyces cerevisiae YOR065W CYT1 Cytochrome c1, component of the mitochondrial respiratory chain; KLTH0F17600p 1421027 8293184 KLTH0F17600g Lachancea thermotolerans CBS 6340 KLTH0F17600p XP_002554949.1 1419964 D 559295 CDS KLTH0F17622g 255717338 8293185 1422812..1423897 1 NC_013082.1 similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W ECM4 Non-essential protein of unknown function and to YMR251W uniprot|Q04806 Saccharomyces cerevisiae YMR251W Hypothetical ORF; KLTH0F17622p 1423897 8293185 KLTH0F17622g Lachancea thermotolerans CBS 6340 KLTH0F17622p XP_002554950.1 1422812 D 559295 CDS KLTH0F17644g 255717340 8293186 1424304..1425644 1 NC_013082.1 some similarities with uniprot|O00026 Saccharomyces cerevisiae YOR066W Protein of unknown function potential Cdc28p substrate; KLTH0F17644p 1425644 8293186 KLTH0F17644g Lachancea thermotolerans CBS 6340 KLTH0F17644p XP_002554951.1 1424304 D 559295 CDS KLTH0F17666g 255717342 8293187 complement(1425802..1427469) 1 NC_013082.1 highly similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 adds glucose to the dolichol- linked oligosaccharide precursor prior to transfer to protein glycosyl transferase; KLTH0F17666p 1427469 8293187 KLTH0F17666g Lachancea thermotolerans CBS 6340 KLTH0F17666p XP_002554952.1 1425802 R 559295 CDS KLTH0F17688g 255717344 8293188 1427609..1429504 1 NC_013082.1 similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W VPS5 Component of the retromer coat that retrieves proteins from late endosomes sorting nexin I homolog; KLTH0F17688p 1429504 8293188 KLTH0F17688g Lachancea thermotolerans CBS 6340 KLTH0F17688p XP_002554953.1 1427609 D 559295 CDS KLTH0F17710g 255717346 8293189 complement(1429586..1432033) 1 NC_013082.1 similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 Protein required for cell viability; KLTH0F17710p 1432033 8293189 KLTH0F17710g Lachancea thermotolerans CBS 6340 KLTH0F17710p XP_002554954.1 1429586 R 559295 CDS KLTH0F17732g 255717348 8293190 complement(1432354..1434060) 1 NC_013082.1 similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p Sec4p Ypt7p and Ypt51p (in vitro) involved in vesicle docking and fusion; KLTH0F17732p 1434060 8293190 KLTH0F17732g Lachancea thermotolerans CBS 6340 KLTH0F17732p XP_002554955.1 1432354 R 559295 CDS KLTH0F17754g 255717350 8293191 1434845..1435807 1 NC_013082.1 highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5 10- methylenetetrahydrafolate dehydrogenase plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p repressed by adenine and may be induced by inositol and choline; KLTH0F17754p 1435807 8293191 KLTH0F17754g Lachancea thermotolerans CBS 6340 KLTH0F17754p XP_002554956.1 1434845 D 559295 CDS KLTH0F17776g 255717352 8293192 complement(join(1435955..1436978,1437061..1437074)) 1 NC_013082.1 highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2; KLTH0F17776p 1437074 8293192 KLTH0F17776g Lachancea thermotolerans CBS 6340 KLTH0F17776p XP_002554957.1 1435955 R 559295 CDS KLTH0F17798g 255717354 8293193 1437309..1440704 1 NC_013082.1 similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; KLTH0F17798p 1440704 8293193 KLTH0F17798g Lachancea thermotolerans CBS 6340 KLTH0F17798p XP_002554958.1 1437309 D 559295 CDS KLTH0F17820g 255717356 8293194 complement(1440765..1441256) 1 NC_013082.1 weakly similar to uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; KLTH0F17820p 1441256 8293194 KLTH0F17820g Lachancea thermotolerans CBS 6340 KLTH0F17820p XP_002554959.1 1440765 R 559295 CDS KLTH0F17842g 255717358 8293195 1441411..1443213 1 NC_013082.1 weakly similar to uniprot|Q08490 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint involved in sensing lack of tension on mitotic chromosomes protects centromeric Rec8p at meiosis I required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; KLTH0F17842p 1443213 8293195 KLTH0F17842g Lachancea thermotolerans CBS 6340 KLTH0F17842p XP_002554960.1 1441411 D 559295 CDS KLTH0F17864g 255717360 8293196 complement(1443235..1444221) 1 NC_013082.1 highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides expression is induced at G1/S; KLTH0F17864p 1444221 8293196 KLTH0F17864g Lachancea thermotolerans CBS 6340 KLTH0F17864p XP_002554961.1 1443235 R 559295 CDS KLTH0F17886g 255717362 8293197 1444721..1445704 1 NC_013082.1 similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex potential Cdc28p substrate endoplasmic reticulum t- SNARE coprecipitates with Sec20p Tip1p. and Sec22p; KLTH0F17886p 1445704 8293197 KLTH0F17886g Lachancea thermotolerans CBS 6340 KLTH0F17886p XP_002554962.1 1444721 D 559295 CDS KLTH0F17908g 255717364 8293198 complement(join(1445723..1447320,1448299..1448566)) 1 NC_013082.1 similar to uniprot|P32769 Saccharomyces cerevisiae YKR084C; KLTH0F17908p 1448566 8293198 KLTH0F17908g Lachancea thermotolerans CBS 6340 KLTH0F17908p XP_002554963.1 1445723 R 559295 CDS KLTH0F17930g 255717366 8293199 1449331..1449801 1 NC_013082.1 conserved hypothetical protein; KLTH0F17930p 1449801 8293199 KLTH0F17930g Lachancea thermotolerans CBS 6340 KLTH0F17930p XP_002554964.1 1449331 D 559295 CDS KLTH0F17952g 255717368 8293200 complement(1450246..1450845) 1 NC_013082.1 similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit; KLTH0F17952p 1450845 8293200 KLTH0F17952g Lachancea thermotolerans CBS 6340 KLTH0F17952p XP_002554965.1 1450246 R 559295 CDS KLTH0F17974g 255717370 8293201 1451196..1454522 1 NC_013082.1 similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing exhibits ATP- dependent RNA unwinding activity; KLTH0F17974p 1454522 8293201 KLTH0F17974g Lachancea thermotolerans CBS 6340 KLTH0F17974p XP_002554966.1 1451196 D 559295 CDS KLTH0F17996g 255717372 8293202 complement(1454567..1455601) 1 NC_013082.1 highly similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane involved in turnover of membrane-embedded proteins member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes; KLTH0F17996p 1455601 8293202 KLTH0F17996g Lachancea thermotolerans CBS 6340 KLTH0F17996p XP_002554967.1 1454567 R 559295 CDS KLTH0F18018g 255717374 8293203 1455780..1456502 1 NC_013082.1 similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W; KLTH0F18018p 1456502 8293203 KLTH0F18018g Lachancea thermotolerans CBS 6340 KLTH0F18018p XP_002554968.1 1455780 D 559295 CDS KLTH0F18040g 255717376 8293204 complement(1456546..1457472) 1 NC_013082.1 similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0F18040p 1457472 8293204 KLTH0F18040g Lachancea thermotolerans CBS 6340 KLTH0F18040p XP_002554969.1 1456546 R 559295 CDS KLTH0F18062g 255717378 8293205 1458788..1459639 1 NC_013082.1 conserved hypothetical protein; KLTH0F18062p 1459639 8293205 KLTH0F18062g Lachancea thermotolerans CBS 6340 KLTH0F18062p XP_002554970.1 1458788 D 559295 CDS KLTH0F18084g 255717380 8293206 1459961..1460533 1 NC_013082.1 conserved hypothetical protein; KLTH0F18084p 1460533 8293206 KLTH0F18084g Lachancea thermotolerans CBS 6340 KLTH0F18084p XP_002554971.1 1459961 D 559295 CDS KLTH0F18106g 255717382 8293207 1460741..1461436 1 NC_013082.1 some similarities with uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA originally isolated as bud-site selection mutant that displays a random budding pattern; KLTH0F18106p 1461436 8293207 KLTH0F18106g Lachancea thermotolerans CBS 6340 KLTH0F18106p XP_002554972.1 1460741 D 559295 CDS KLTH0F18128g 255717384 8293208 complement(1461549..1462508) 1 NC_013082.1 similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis overproduction suppresses the sod1 (copper zinc superoxide dismutase) null mutation; KLTH0F18128p 1462508 8293208 KLTH0F18128g Lachancea thermotolerans CBS 6340 KLTH0F18128p XP_002554973.1 1461549 R 559295 CDS KLTH0F18150g 255717386 8293209 1462613..1464682 1 NC_013082.1 weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Protein of unknown function involved in invasive and pseudohyphal growth; KLTH0F18150p 1464682 8293209 KLTH0F18150g Lachancea thermotolerans CBS 6340 KLTH0F18150p XP_002554974.1 1462613 D 559295 CDS KLTH0F18172g 255717388 8293210 complement(1464768..1467317) 1 NC_013082.1 similar to uniprot|P36165 YKR089C Saccharomyces cerevisiae STC1 Protein of unknown function found in lipid particles potential Cdc28p substrate; KLTH0F18172p 1467317 8293210 KLTH0F18172g Lachancea thermotolerans CBS 6340 KLTH0F18172p XP_002554975.1 1464768 R 559295 CDS KLTH0F18194g 255717390 8293211 1468098..1469597 1 NC_013082.1 similar to uniprot|P40016 Saccharomyces cerevisiae YER021W; KLTH0F18194p 1469597 8293211 KLTH0F18194g Lachancea thermotolerans CBS 6340 KLTH0F18194p XP_002554976.1 1468098 D 559295 CDS KLTH0F18216g 255717392 8293212 1469796..1471775 1 NC_013082.1 similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 subunit of RNA polymerase II holoenzyme/mediator complex; KLTH0F18216p 1471775 8293212 KLTH0F18216g Lachancea thermotolerans CBS 6340 KLTH0F18216p XP_002554977.1 1469796 D 559295 CDS KLTH0F18238g 255717394 8293213 complement(1471826..1472359) 1 NC_013082.1 similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function; KLTH0F18238p 1472359 8293213 KLTH0F18238g Lachancea thermotolerans CBS 6340 KLTH0F18238p XP_002554978.1 1471826 R 559295 CDS KLTH0F18260g 255717396 8293214 complement(1472531..1474930) 1 NC_013082.1 similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C Hypothetical ORF; KLTH0F18260p 1474930 8293214 KLTH0F18260g Lachancea thermotolerans CBS 6340 KLTH0F18260p XP_002554979.1 1472531 R 559295 CDS KLTH0F18282g 255717398 8293215 1475163..1476020 1 NC_013082.1 highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase catalyzes the last step in proline biosynthesis; KLTH0F18282p 1476020 8293215 KLTH0F18282g Lachancea thermotolerans CBS 6340 KLTH0F18282p XP_002554980.1 1475163 D 559295 CDS KLTH0F18304g 255717400 8293216 1477216..1478742 1 NC_013082.1 highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0F18304p 1478742 8293216 KLTH0F18304g Lachancea thermotolerans CBS 6340 KLTH0F18304p XP_002554981.1 1477216 D 559295 CDS KLTH0F18326g 255717402 8293217 1479366..1480808 1 NC_013082.1 similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system 3'- untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins; KLTH0F18326p 1480808 8293217 KLTH0F18326g Lachancea thermotolerans CBS 6340 KLTH0F18326p XP_002554982.1 1479366 D 559295 CDS KLTH0F18348g 255717404 8293218 1481471..1482154 1 NC_013082.1 highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W; KLTH0F18348p 1482154 8293218 KLTH0F18348g Lachancea thermotolerans CBS 6340 KLTH0F18348p XP_002554983.1 1481471 D 559295 CDS KLTH0F18370g 255717406 8293219 complement(1483090..1484400) 1 NC_013082.1 similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Hypothetical ORF; KLTH0F18370p 1484400 8293219 KLTH0F18370g Lachancea thermotolerans CBS 6340 KLTH0F18370p XP_002554984.1 1483090 R 559295 CDS KLTH0F18392g 255717408 8293220 1484590..1487211 1 NC_013082.1 similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate an intermediate in leucine biosynthesis; KLTH0F18392p 1487211 8293220 KLTH0F18392g Lachancea thermotolerans CBS 6340 KLTH0F18392p XP_002554985.1 1484590 D 559295 CDS KLTH0F18414g 255717410 8293221 1487594..1489153 1 NC_013082.1 highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 involved in the identification of the start codon binds GTP when forming the ternary complex with GTP and tRNAi-Met; KLTH0F18414p 1489153 8293221 KLTH0F18414g Lachancea thermotolerans CBS 6340 KLTH0F18414p XP_002554986.1 1487594 D 559295 CDS KLTH0F18436g 255717412 8293222 complement(1489345..1491537) 1 NC_013082.1 similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 Protein involved in desensitization to alpha- factor pheromone member of the RGS (regulator of G-protein signalling) family GTPase- activating protein; KLTH0F18436p 1491537 8293222 KLTH0F18436g Lachancea thermotolerans CBS 6340 KLTH0F18436p XP_002554987.1 1489345 R 559295 CDS KLTH0F18458g 255717414 8293223 complement(1491777..1493663) 1 NC_013082.1 similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 CDC28/cdc2 related protein kinase; KLTH0F18458p 1493663 8293223 KLTH0F18458g Lachancea thermotolerans CBS 6340 KLTH0F18458p XP_002554988.1 1491777 R 559295 CDS KLTH0F18480g 255717416 8293224 complement(1494006..1495781) 1 NC_013082.1 similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; KLTH0F18480p 1495781 8293224 KLTH0F18480g Lachancea thermotolerans CBS 6340 KLTH0F18480p XP_002554989.1 1494006 R 559295 CDS KLTH0F18502g 255717418 8293225 1496235..1497038 1 NC_013082.1 conserved hypothetical protein; KLTH0F18502p 1497038 8293225 KLTH0F18502g Lachancea thermotolerans CBS 6340 KLTH0F18502p XP_002554990.1 1496235 D 559295 CDS KLTH0F18524g 255717420 8293226 complement(1497201..1498388) 1 NC_013082.1 similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B; KLTH0F18524p 1498388 8293226 KLTH0F18524g Lachancea thermotolerans CBS 6340 KLTH0F18524p XP_002554991.1 1497201 R 559295 CDS KLTH0F18546g 255717422 8293227 1498810..1507143 1 NC_013082.1 similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria; KLTH0F18546p 1507143 8293227 KLTH0F18546g Lachancea thermotolerans CBS 6340 KLTH0F18546p XP_002554992.1 1498810 D 559295 CDS KLTH0F18568g 255717424 8293228 1507739..1511242 1 NC_013082.1 some similarities with uniprot|Q06211 Saccharomyces cerevisiae YPR164W MMS1 Protein likely involved in protection against replication-dependent DNA damage mutants are sensitive to methyl methanesulfonate (MMS) implicated in regulation of Ty1 transposition; KLTH0F18568p 1511242 8293228 KLTH0F18568g Lachancea thermotolerans CBS 6340 KLTH0F18568p XP_002554993.1 1507739 D 559295 CDS KLTH0F18590g 255717426 8293229 1511729..1512355 1 NC_013082.1 highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p); KLTH0F18590p 1512355 8293229 KLTH0F18590g Lachancea thermotolerans CBS 6340 KLTH0F18590p XP_002554994.1 1511729 D 559295 CDS KLTH0F18612g 255717428 8293230 1513182..1513811 1 NC_013082.1 similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p); KLTH0F18612p 1513811 8293230 KLTH0F18612g Lachancea thermotolerans CBS 6340 KLTH0F18612p XP_002554995.1 1513182 D 559295 CDS KLTH0F18634g 255717430 8293231 complement(1514101..1514448) 1 NC_013082.1 highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit; KLTH0F18634p 1514448 8293231 KLTH0F18634g Lachancea thermotolerans CBS 6340 KLTH0F18634p XP_002554996.1 1514101 R 559295 CDS KLTH0F18656g 255717432 8293232 complement(1514737..1515522) 1 NC_013082.1 highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'- bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism; KLTH0F18656p 1515522 8293232 KLTH0F18656g Lachancea thermotolerans CBS 6340 KLTH0F18656p XP_002554997.1 1514737 R 559295 CDS KLTH0F18678g 255717434 8293233 1515905..1516360 1 NC_013082.1 similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription; KLTH0F18678p 1516360 8293233 KLTH0F18678g Lachancea thermotolerans CBS 6340 KLTH0F18678p XP_002554998.1 1515905 D 559295 CDS KLTH0F18700g 255717436 8293234 1516494..1518062 1 NC_013082.1 similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein; KLTH0F18700p 1518062 8293234 KLTH0F18700g Lachancea thermotolerans CBS 6340 KLTH0F18700p XP_002554999.1 1516494 D 559295 CDS KLTH0F18744g 255717438 8293236 1519346..1520896 1 NC_013082.1 similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter; KLTH0F18744p 1520896 8293236 KLTH0F18744g Lachancea thermotolerans CBS 6340 KLTH0F18744p XP_002555000.1 1519346 D 559295 CDS KLTH0F18766g 255717440 8293237 complement(1521018..1522784) 1 NC_013082.1 weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; KLTH0F18766p 1522784 8293237 KLTH0F18766g Lachancea thermotolerans CBS 6340 KLTH0F18766p XP_002555001.1 1521018 R 559295 CDS KLTH0F18788g 255717442 8293238 1523598..1524911 1 NC_013082.1 highly similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0F18788p 1524911 8293238 KLTH0F18788g Lachancea thermotolerans CBS 6340 KLTH0F18788p XP_002555002.1 1523598 D 559295 CDS KLTH0F18810g 255717444 8293239 complement(1525047..1526393) 1 NC_013082.1 similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells; KLTH0F18810p 1526393 8293239 KLTH0F18810g Lachancea thermotolerans CBS 6340 KLTH0F18810p XP_002555003.1 1525047 R 559295 CDS KLTH0F18832g 255717446 8293240 complement(1526669..1528315) 1 NC_013082.1 weakly similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W Hypothetical ORF; KLTH0F18832p 1528315 8293240 KLTH0F18832g Lachancea thermotolerans CBS 6340 KLTH0F18832p XP_002555004.1 1526669 R 559295 CDS KLTH0F18854g 255717448 8293241 1529096..1530283 1 NC_013082.1 similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in gluconeogenesis and glyoxylate cycle; KLTH0F18854p 1530283 8293241 KLTH0F18854g Lachancea thermotolerans CBS 6340 KLTH0F18854p XP_002555005.1 1529096 D 559295 CDS KLTH0F18876g 255717450 8293242 1530535..1531491 1 NC_013082.1 similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Hypothetical ORF; KLTH0F18876p 1531491 8293242 KLTH0F18876g Lachancea thermotolerans CBS 6340 KLTH0F18876p XP_002555006.1 1530535 D 559295 CDS KLTH0F18898g 255717452 8293243 complement(join(1531578..1531993,1532344..1532356)) 1 NC_013082.1 highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit; KLTH0F18898p 1532356 8293243 KLTH0F18898g Lachancea thermotolerans CBS 6340 KLTH0F18898p XP_002555007.1 1531578 R 559295 CDS KLTH0F18920g 255717454 8293244 complement(1533193..1533816) 1 NC_013082.1 similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit essential for viability unlike most other mitoribosomal proteins; KLTH0F18920p 1533816 8293244 KLTH0F18920g Lachancea thermotolerans CBS 6340 KLTH0F18920p XP_002555008.1 1533193 R 559295 CDS KLTH0F18942g 255717456 8293245 1535941..1537032 1 NC_013082.1 highly similar to uniprot|P21965 Saccharomyces cerevisiae YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family; KLTH0F18942p 1537032 8293245 KLTH0F18942g Lachancea thermotolerans CBS 6340 KLTH0F18942p XP_002555009.1 1535941 D 559295 CDS KLTH0F18964g 255717458 8293246 complement(1537367..1537897) 1 NC_013082.1 similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68; KLTH0F18964p 1537897 8293246 KLTH0F18964g Lachancea thermotolerans CBS 6340 KLTH0F18964p XP_002555010.1 1537367 R 559295 CDS KLTH0F18986g 255717460 8293247 1538301..1539989 1 NC_013082.1 similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis physically and functionally interacts with Krr1p; KLTH0F18986p 1539989 8293247 KLTH0F18986g Lachancea thermotolerans CBS 6340 KLTH0F18986p XP_002555011.1 1538301 D 559295 CDS KLTH0F19008g 255717462 8293248 complement(1540145..1542505) 1 NC_013082.1 similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter expression and turnover are regulated by Mg(2+) concentration overexpression confers increased tolerance to Al(3+) and Ga(3+) ions and similar to YFL050C uniprot|P43553 Saccharomyces cerevisiae YFL050C ALR2 Probable Mg(2+)transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; KLTH0F19008p 1542505 8293248 KLTH0F19008g Lachancea thermotolerans CBS 6340 KLTH0F19008p XP_002555012.1 1540145 R 559295 CDS KLTH0F19030g 255717464 8293249 complement(1543107..1544060) 1 NC_013082.1 weakly similar to uniprot|P42845 Saccharomyces cerevisiae YNL309W STB1 Protein with a role in regulation of MBF-specific transcription at Start phosphorylated by Cln-Cdc28p kinases in vitro unphosphorylated form binds Swi6p and binding is required for Stb1p function expression is cell-cycle regulated; KLTH0F19030p 1544060 8293249 KLTH0F19030g Lachancea thermotolerans CBS 6340 KLTH0F19030p XP_002555013.1 1543107 R 559295 CDS KLTH0F19052g 255717466 8293250 1544223..1544765 1 NC_013082.1 similar to uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Essential component of the mitochondrial import system zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; KLTH0F19052p 1544765 8293250 KLTH0F19052g Lachancea thermotolerans CBS 6340 KLTH0F19052p XP_002555014.1 1544223 D 559295 CDS KLTH0F19074g 255717468 8293251 1545060..1547249 1 NC_013082.1 similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C F-box protein; KLTH0F19074p 1547249 8293251 KLTH0F19074g Lachancea thermotolerans CBS 6340 KLTH0F19074p XP_002555015.1 1545060 D 559295 CDS KLTH0F19096g 255717470 8293252 complement(1547280..1548749) 1 NC_013082.1 similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall; KLTH0F19096p 1548749 8293252 KLTH0F19096g Lachancea thermotolerans CBS 6340 KLTH0F19096p XP_002555016.1 1547280 R 559295 CDS KLTH0F19118g 255717472 8293253 complement(join(1548991..1549820,1549887..1549893)) 1 NC_013082.1 similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination; KLTH0F19118p 1549893 8293253 KLTH0F19118g Lachancea thermotolerans CBS 6340 KLTH0F19118p XP_002555017.1 1548991 R 559295 CDS KLTH0F19140g 255717474 8293254 1550056..1552830 1 NC_013082.1 similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C Protein required for cell viability; KLTH0F19140p 1552830 8293254 KLTH0F19140g Lachancea thermotolerans CBS 6340 KLTH0F19140p XP_002555018.1 1550056 D 559295 CDS KLTH0F19162g 255717476 8293255 complement(1552999..1553868) 1 NC_013082.1 weakly similar to uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate contains an UISALL DNA-binding a transcriptional activation and a coiled-coil domain; KLTH0F19162p 1553868 8293255 KLTH0F19162g Lachancea thermotolerans CBS 6340 KLTH0F19162p XP_002555019.1 1552999 R 559295 CDS KLTH0F19184g 255717478 8293256 1554450..1555421 1 NC_013082.1 similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; KLTH0F19184p 1555421 8293256 KLTH0F19184g Lachancea thermotolerans CBS 6340 KLTH0F19184p XP_002555020.1 1554450 D 559295 CDS KLTH0F19206g 255717480 8293257 1555594..1556592 1 NC_013082.1 similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase catalyzes the conversion of prephanate to phenylpyruvate which is a step in the phenylalanine biosynthesis pathway; KLTH0F19206p 1556592 8293257 KLTH0F19206g Lachancea thermotolerans CBS 6340 KLTH0F19206p XP_002555021.1 1555594 D 559295 CDS KLTH0F19228g 255717482 8293258 complement(1556655..1556987) 1 NC_013082.1 similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin- F-box ubiquitin protein ligases (SCF) required for Gic2p Far1p Sic1p and Cln2p degradation may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; KLTH0F19228p 1556987 8293258 KLTH0F19228g Lachancea thermotolerans CBS 6340 KLTH0F19228p XP_002555022.1 1556655 R 559295 CDS KLTH0F19250g 255717484 8293259 1557279..1557941 1 NC_013082.1 similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C; KLTH0F19250p 1557941 8293259 KLTH0F19250g Lachancea thermotolerans CBS 6340 KLTH0F19250p XP_002555023.1 1557279 D 559295 CDS KLTH0F19272g 255717486 8293260 join(1558288..1558366,1558617..1560049) 1 NC_013082.1 similar to uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase has negligible fructose-2 6-bisphosphatase activity inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate expression induced by glucose and sucrose transcriptional regulation involves protein kinase A; KLTH0F19272p 1560049 8293260 KLTH0F19272g Lachancea thermotolerans CBS 6340 KLTH0F19272p XP_002555024.1 1558288 D 559295 CDS KLTH0F19294g 255717488 8293261 complement(1560167..1561522) 1 NC_013082.1 similar to uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex; KLTH0F19294p 1561522 8293261 KLTH0F19294g Lachancea thermotolerans CBS 6340 KLTH0F19294p XP_002555025.1 1560167 R 559295 CDS KLTH0F19316g 255717490 8293262 complement(1562014..1563390) 1 NC_013082.1 similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments ORF exhibits genomic organization compatible with a translational readthrough- dependent mode of expression; KLTH0F19316p 1563390 8293262 KLTH0F19316g Lachancea thermotolerans CBS 6340 KLTH0F19316p XP_002555026.1 1562014 R 559295 CDS KLTH0F19338g 255717492 8293263 1564555..1568427 1 NC_013082.1 similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C Hypothetical ORF; KLTH0F19338p 1568427 8293263 KLTH0F19338g Lachancea thermotolerans CBS 6340 KLTH0F19338p XP_002555027.1 1564555 D 559295 CDS KLTH0F19360g 255717494 8293264 complement(1568441..1569286) 1 NC_013082.1 similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Hypothetical ORF; KLTH0F19360p 1569286 8293264 KLTH0F19360g Lachancea thermotolerans CBS 6340 KLTH0F19360p XP_002555028.1 1568441 R 559295 CDS KLTH0F19382g 255717496 8293265 1570473..1571102 1 NC_013082.1 highly similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p); KLTH0F19382p 1571102 8293265 KLTH0F19382g Lachancea thermotolerans CBS 6340 KLTH0F19382p XP_002555029.1 1570473 D 559295 CDS KLTH0F19404g 255717498 8293266 complement(1571210..1573618) 1 NC_013082.1 similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W Protein of unknown function potential Cdc28p substrate; KLTH0F19404p 1573618 8293266 KLTH0F19404g Lachancea thermotolerans CBS 6340 KLTH0F19404p XP_002555030.1 1571210 R 559295 CDS KLTH0F19426g 255717500 8293267 1574646..1575440 1 NC_013082.1 weakly similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor; KLTH0F19426p 1575440 8293267 KLTH0F19426g Lachancea thermotolerans CBS 6340 KLTH0F19426p XP_002555031.1 1574646 D 559295 CDS KLTH0F19448g 255717502 8293268 complement(1575523..1576797) 1 NC_013082.1 highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; KLTH0F19448p 1576797 8293268 KLTH0F19448g Lachancea thermotolerans CBS 6340 KLTH0F19448p XP_002555032.1 1575523 R 559295 CDS KLTH0F19470g 255717504 8293269 complement(1577013..1578245) 1 NC_013082.1 similar to uniprot|P42838 YNL323W Saccharomyces cerevisiae LEM3 Membrane protein of the plasma membrane and ER; KLTH0F19470p 1578245 8293269 KLTH0F19470g Lachancea thermotolerans CBS 6340 KLTH0F19470p XP_002555033.1 1577013 R 559295 CDS KLTH0F19492g 255717506 8293270 1578991..1580511 1 NC_013082.1 similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C SNG1 Protein involved in nitrosoguanidine resistance and weakly similar to YJR015W uniprot|P47090 Saccharomyces cerevisiae YJR015W Hypothetical ORF; KLTH0F19492p 1580511 8293270 KLTH0F19492g Lachancea thermotolerans CBS 6340 KLTH0F19492p XP_002555034.1 1578991 D 559295 CDS KLTH0F19514g 255717508 8293271 complement(1580584..1582683) 1 NC_013082.1 similar to uniprot|Q08282 YOL141w Saccharomyces cerevisiae PPM2 Putative carboxyl methyl transferase; KLTH0F19514p 1582683 8293271 KLTH0F19514g Lachancea thermotolerans CBS 6340 KLTH0F19514p XP_002555035.1 1580584 R 559295 CDS KLTH0F19536g 255717510 8293272 1582844..1585408 1 NC_013082.1 similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Protein required for efficient mating member of a family of eukaryotic proteins that contain a domain homologous to Sac1p; KLTH0F19536p 1585408 8293272 KLTH0F19536g Lachancea thermotolerans CBS 6340 KLTH0F19536p XP_002555036.1 1582844 D 559295 CDS KLTH0F19558g 255717512 8293273 complement(1585454..1586164) 1 NC_013082.1 similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Ribosomal RNA Processing Rrp40p; KLTH0F19558p 1586164 8293273 KLTH0F19558g Lachancea thermotolerans CBS 6340 KLTH0F19558p XP_002555037.1 1585454 R 559295 CDS KLTH0F19580g 255717514 8293274 1586776..1587804 1 NC_013082.1 similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p one of three yeast DHHC-cysteine rich domain proteins (Pfa3p Erf2p Akr1p) with palmitoyltransferase activity required for vacuolar integrity under stress conditions; KLTH0F19580p 1587804 8293274 KLTH0F19580g Lachancea thermotolerans CBS 6340 KLTH0F19580p XP_002555038.1 1586776 D 559295 CDS KLTH0F19602g 255717516 8293275 complement(1587934..1590936) 1 NC_013082.1 weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)- anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; KLTH0F19602p 1590936 8293275 KLTH0F19602g Lachancea thermotolerans CBS 6340 KLTH0F19602p XP_002555039.1 1587934 R 559295 CDS KLTH0F19624g 255717518 8293276 1591500..1591937 1 NC_013082.1 similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Protein of the mitochondrial inner membrane function partially overlaps that of Mdj1p which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix member of the DnaJ family; KLTH0F19624p 1591937 8293276 KLTH0F19624g Lachancea thermotolerans CBS 6340 KLTH0F19624p XP_002555040.1 1591500 D 559295 CDS KLTH0F19646g 255717520 8293277 1592186..1595320 1 NC_013082.1 similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 Required for peroxisome assembly Member of the AAA-protein family that includes NSFp and PEX1p; KLTH0F19646p 1595320 8293277 KLTH0F19646g Lachancea thermotolerans CBS 6340 KLTH0F19646p XP_002555041.1 1592186 D 559295 CDS KLTH0F19668g 255717522 8293278 1595709..1597007 1 NC_013082.1 highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase regulates transcription and silencing; KLTH0F19668p 1597007 8293278 KLTH0F19668g Lachancea thermotolerans CBS 6340 KLTH0F19668p XP_002555042.1 1595709 D 559295 CDS KLTH0F19690g 255717524 8293279 1597140..1597640 1 NC_013082.1 highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6 7-dimethyl-8- ribityllumazine synthase also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin; KLTH0F19690p 1597640 8293279 KLTH0F19690g Lachancea thermotolerans CBS 6340 KLTH0F19690p XP_002555043.1 1597140 D 559295 CDS KLTH0F19712g 255717526 8293280 complement(1597689..1599071) 1 NC_013082.1 similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis; KLTH0F19712p 1599071 8293280 KLTH0F19712g Lachancea thermotolerans CBS 6340 KLTH0F19712p XP_002555044.1 1597689 R 559295 CDS KLTH0F19734g 255717528 8293281 1599275..1602520 1 NC_013082.1 similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes including cyclin genes contains TPR repeats; KLTH0F19734p 1602520 8293281 KLTH0F19734g Lachancea thermotolerans CBS 6340 KLTH0F19734p XP_002555045.1 1599275 D 559295 CDS KLTH0F19756g 255717530 8293282 complement(1602644..1603192) 1 NC_013082.1 similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; KLTH0F19756p 1603192 8293282 KLTH0F19756g Lachancea thermotolerans CBS 6340 KLTH0F19756p XP_002555046.1 1602644 R 559295 CDS KLTH0F19778g 255717532 8293283 1603376..1604041 1 NC_013082.1 similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation most abundant protein in the peroxisomal membrane regulated by Adr1p and Pip2p-Oaf1p promoter contains ORE and UAS1-like elements; KLTH0F19778p 1604041 8293283 KLTH0F19778g Lachancea thermotolerans CBS 6340 KLTH0F19778p XP_002555047.1 1603376 D 559295 CDS KLTH0F19800g 255717534 8293284 1604235..1605992 1 NC_013082.1 weakly similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex involved in maintaining the integrity of the complex; KLTH0F19800p 1605992 8293284 KLTH0F19800g Lachancea thermotolerans CBS 6340 KLTH0F19800p XP_002555048.1 1604235 D 559295 CDS KLTH0F19822g 255717536 8293285 complement(1606053..1606667) 1 NC_013082.1 similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Decapping enzyme essential phosphoprotein component of mRNA decapping complex plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation regulated by DEAD box protein Dhh1p; KLTH0F19822p 1606667 8293285 KLTH0F19822g Lachancea thermotolerans CBS 6340 KLTH0F19822p XP_002555049.1 1606053 R 559295 CDS KLTH0F19844g 255717538 8293286 1607819..1609816 1 NC_013082.1 weakly similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway; KLTH0F19844p 1609816 8293286 KLTH0F19844g Lachancea thermotolerans CBS 6340 KLTH0F19844p XP_002555050.1 1607819 D 559295 CDS KLTH0F19866g 255717540 8293287 1611088..1612269 1 NC_013082.1 some similarities with uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p; KLTH0F19866p 1612269 8293287 KLTH0F19866g Lachancea thermotolerans CBS 6340 KLTH0F19866p XP_002555051.1 1611088 D 559295 CDS KLTH0F19888g 255717542 8293288 1614006..1618226 1 NC_013082.1 some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation; KLTH0F19888p 1618226 8293288 KLTH0F19888g Lachancea thermotolerans CBS 6340 KLTH0F19888p XP_002555052.1 1614006 D 559295 CDS KLTH0F19932g 255717544 8293290 1626554..1627174 1 NC_013082.1 conserved hypothetical protein; KLTH0F19932p 1627174 8293290 KLTH0F19932g Lachancea thermotolerans CBS 6340 KLTH0F19932p XP_002555053.1 1626554 D 559295 CDS KLTH0F19954g 255717546 8293291 1628189..1629025 1 NC_013082.1 conserved hypothetical protein; KLTH0F19954p 1629025 8293291 KLTH0F19954g Lachancea thermotolerans CBS 6340 KLTH0F19954p XP_002555054.1 1628189 D 559295 CDS KLTH0G00198g 255717549 8293306 5908..7284 1 NC_013083.1 similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores; KLTH0G00198p 7284 8293306 KLTH0G00198g Lachancea thermotolerans CBS 6340 KLTH0G00198p XP_002555055.1 5908 D 559295 CDS KLTH0G00396g 255717551 8293314 complement(21210..22325) 1 NC_013083.1 conserved hypothetical protein; KLTH0G00396p 22325 8293314 KLTH0G00396g Lachancea thermotolerans CBS 6340 KLTH0G00396p XP_002555056.1 21210 R 559295 CDS KLTH0G00418g 255717553 8293315 complement(23130..24836) 1 NC_013083.1 similar to uniprot|Q12198 Saccharomyces cerevisiae YLL058W Hypothetical ORF; KLTH0G00418p 24836 8293315 KLTH0G00418g Lachancea thermotolerans CBS 6340 KLTH0G00418p XP_002555057.1 23130 R 559295 CDS KLTH0G00440g 255717555 8293316 28632..30089 1 NC_013083.1 similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W HXK2 Hexokinase isoenzyme 2 catalyzes phosphorylation of glucose in the cytosol predominate hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; KLTH0G00440p 30089 8293316 KLTH0G00440g Lachancea thermotolerans CBS 6340 KLTH0G00440p XP_002555058.1 28632 D 559295 CDS KLTH0G00462g 255717557 8293317 complement(30407..31204) 1 NC_013083.1 similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1 which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p; KLTH0G00462p 31204 8293317 KLTH0G00462g Lachancea thermotolerans CBS 6340 KLTH0G00462p XP_002555059.1 30407 R 559295 CDS KLTH0G00484g 255717559 8293318 complement(32295..34040) 1 NC_013083.1 highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction regulates the subcellular location of Rtg1p and Rtg3p transcriptional activators of the retrograde (RTG) and TOR pathways Rtg2p is inhibited by the phosphorylated form of Mks1p; KLTH0G00484p 34040 8293318 KLTH0G00484g Lachancea thermotolerans CBS 6340 KLTH0G00484p XP_002555060.1 32295 R 559295 CDS KLTH0G00506g 255717561 8293319 35079..36386 1 NC_013083.1 weakly similar to uniprot|P53060 Saccharomyces cerevisiae YGL250W Hypothetical ORF; KLTH0G00506p 36386 8293319 KLTH0G00506g Lachancea thermotolerans CBS 6340 KLTH0G00506p XP_002555061.1 35079 D 559295 CDS KLTH0G00528g 255717563 8293320 36584..38485 1 NC_013083.1 similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER; KLTH0G00528p 38485 8293320 KLTH0G00528g Lachancea thermotolerans CBS 6340 KLTH0G00528p XP_002555062.1 36584 D 559295 CDS KLTH0G00550g 255717565 8293321 38715..39512 1 NC_013083.1 highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 20S proteasome beta-type subunit; KLTH0G00550p 39512 8293321 KLTH0G00550g Lachancea thermotolerans CBS 6340 KLTH0G00550p XP_002555063.1 38715 D 559295 CDS KLTH0G00572g 255717567 8293322 40280..41368 1 NC_013083.1 similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase controls glucose and intracellular acidification-induced cAMP signaling target of the cAMP- protein kinase A (PKA) pathway glucose induces transcription and inhibits translation; KLTH0G00572p 41368 8293322 KLTH0G00572g Lachancea thermotolerans CBS 6340 KLTH0G00572p XP_002555064.1 40280 D 559295 CDS KLTH0G00594g 255717569 8293323 complement(41445..41825) 1 NC_013083.1 similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W; KLTH0G00594p 41825 8293323 KLTH0G00594g Lachancea thermotolerans CBS 6340 KLTH0G00594p XP_002555065.1 41445 R 559295 CDS KLTH0G00616g 255717571 8293324 42539..43120 1 NC_013083.1 similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport depletion alters nucleoporin distribution and nuclear envelope morphology suggesting a role in the spatial organization of nuclear pores; KLTH0G00616p 43120 8293324 KLTH0G00616g Lachancea thermotolerans CBS 6340 KLTH0G00616p XP_002555066.1 42539 D 559295 CDS KLTH0G00638g 255717573 8293325 43280..44221 1 NC_013083.1 similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters; KLTH0G00638p 44221 8293325 KLTH0G00638g Lachancea thermotolerans CBS 6340 KLTH0G00638p XP_002555067.1 43280 D 559295 CDS KLTH0G00660g 255717575 8293326 complement(44243..45394) 1 NC_013083.1 highly similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing; KLTH0G00660p 45394 8293326 KLTH0G00660g Lachancea thermotolerans CBS 6340 KLTH0G00660p XP_002555068.1 44243 R 559295 CDS KLTH0G00682g 255717577 8293327 45680..47794 1 NC_013083.1 highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS) forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; KLTH0G00682p 47794 8293327 KLTH0G00682g Lachancea thermotolerans CBS 6340 KLTH0G00682p XP_002555069.1 45680 D 559295 CDS KLTH0G00704g 255717579 8293328 complement(47865..49712) 1 NC_013083.1 similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation; KLTH0G00704p 49712 8293328 KLTH0G00704g Lachancea thermotolerans CBS 6340 KLTH0G00704p XP_002555070.1 47865 R 559295 CDS KLTH0G00726g 255717581 8293329 49910..51595 1 NC_013083.1 similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II- associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements; KLTH0G00726p 51595 8293329 KLTH0G00726g Lachancea thermotolerans CBS 6340 KLTH0G00726p XP_002555071.1 49910 D 559295 CDS KLTH0G00748g 255717583 8293330 51751..52908 1 NC_013083.1 similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase deaminates adenosine-37 to inosine in tRNA-Ala; KLTH0G00748p 52908 8293330 KLTH0G00748g Lachancea thermotolerans CBS 6340 KLTH0G00748p XP_002555072.1 51751 D 559295 CDS KLTH0G00770g 255717585 8293331 complement(52958..53473) 1 NC_013083.1 highly similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Hypothetical ORF; KLTH0G00770p 53473 8293331 KLTH0G00770g Lachancea thermotolerans CBS 6340 KLTH0G00770p XP_002555073.1 52958 R 559295 CDS KLTH0G00792g 255717587 8293332 53588..56653 1 NC_013083.1 similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W; KLTH0G00792p 56653 8293332 KLTH0G00792g Lachancea thermotolerans CBS 6340 KLTH0G00792p XP_002555074.1 53588 D 559295 CDS KLTH0G00814g 255717589 8293333 56852..57739 1 NC_013083.1 highly similar to uniprot|P43619 Saccharomyces cerevisiae YFR047C BNA6 Quinolinate phosphoribosyl transferase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; KLTH0G00814p 57739 8293333 KLTH0G00814g Lachancea thermotolerans CBS 6340 KLTH0G00814p XP_002555075.1 56852 D 559295 CDS KLTH0G00836g 255717591 8293334 58467..59195 1 NC_013083.1 weakly similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC) mediates the activity of the APC by contributing to substrate recognition involved in cyclin proteolysis; KLTH0G00836p 59195 8293334 KLTH0G00836g Lachancea thermotolerans CBS 6340 KLTH0G00836p XP_002555076.1 58467 D 559295 CDS KLTH0G00858g 255717593 8293335 59340..62219 1 NC_013083.1 similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) homolog of metazoan CAS protein required for accurate chromosome segregation; KLTH0G00858p 62219 8293335 KLTH0G00858g Lachancea thermotolerans CBS 6340 KLTH0G00858p XP_002555077.1 59340 D 559295 CDS KLTH0G00880g 255717595 8293336 complement(62327..63253) 1 NC_013083.1 some similarities with uniprot|P06774 Saccharomyces cerevisiae YGL237C HAP2 Subunit of the heme- activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences sufficient for both complex assembly and DNA binding; KLTH0G00880p 63253 8293336 KLTH0G00880g Lachancea thermotolerans CBS 6340 KLTH0G00880p XP_002555078.1 62327 R 559295 CDS KLTH0G00902g 255717597 8293337 63474..64391 1 NC_013083.1 no similarity; KLTH0G00902p 64391 8293337 KLTH0G00902g Lachancea thermotolerans CBS 6340 KLTH0G00902p XP_002555079.1 63474 D 559295 CDS KLTH0G00924g 255717599 8293338 complement(64454..66502) 1 NC_013083.1 similar to uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis; KLTH0G00924p 66502 8293338 KLTH0G00924g Lachancea thermotolerans CBS 6340 KLTH0G00924p XP_002555080.1 64454 R 559295 CDS KLTH0G00946g 255717601 8293339 67557..69944 1 NC_013083.1 similar to uniprot|P07244 Saccharomyces cerevisiae YGL234W ADE5 7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; KLTH0G00946p 69944 8293339 KLTH0G00946g Lachancea thermotolerans CBS 6340 KLTH0G00946p XP_002555081.1 67557 D 559295 CDS KLTH0G00968g 255717603 8293340 complement(70012..71049) 1 NC_013083.1 similar to uniprot|P43617 Saccharomyces cerevisiae YFR045W; KLTH0G00968p 71049 8293340 KLTH0G00968g Lachancea thermotolerans CBS 6340 KLTH0G00968p XP_002555082.1 70012 R 559295 CDS KLTH0G00990g 255717605 8293341 71533..73131 1 NC_013083.1 highly similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C Hypothetical ORF; KLTH0G00990p 73131 8293341 KLTH0G00990g Lachancea thermotolerans CBS 6340 KLTH0G00990p XP_002555083.1 71533 D 559295 CDS KLTH0G01012g 255717607 8293342 73388..76018 1 NC_013083.1 similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which mediates polarized targeting of vesicles to active sites of exocytosis Sec15p associates with Sec4p and vesicles; KLTH0G01012p 76018 8293342 KLTH0G01012g Lachancea thermotolerans CBS 6340 KLTH0G01012p XP_002555084.1 73388 D 559295 CDS KLTH0G01034g 255717609 8293343 76546..77376 1 NC_013083.1 similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; KLTH0G01034p 77376 8293343 KLTH0G01034g Lachancea thermotolerans CBS 6340 KLTH0G01034p XP_002555085.1 76546 D 559295 CDS KLTH0G01056g 255717611 8293344 complement(77388..77933) 1 NC_013083.1 similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C Hypothetical ORF; KLTH0G01056p 77933 8293344 KLTH0G01056g Lachancea thermotolerans CBS 6340 KLTH0G01056p XP_002555086.1 77388 R 559295 CDS KLTH0G01078g 255717613 8293345 complement(78199..78660) 1 NC_013083.1 no similarity; KLTH0G01078p 78660 8293345 KLTH0G01078g Lachancea thermotolerans CBS 6340 KLTH0G01078p XP_002555087.1 78199 R 559295 CDS KLTH0G01100g 255717615 8293346 78894..79649 1 NC_013083.1 weakly similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C Hypothetical ORF; KLTH0G01100p 79649 8293346 KLTH0G01100g Lachancea thermotolerans CBS 6340 KLTH0G01100p XP_002555088.1 78894 D 559295 CDS KLTH0G01122g 255717617 8293347 80433..81317 1 NC_013083.1 similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Endoplasmic reticulum protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain; KLTH0G01122p 81317 8293347 KLTH0G01122g Lachancea thermotolerans CBS 6340 KLTH0G01122p XP_002555089.1 80433 D 559295 CDS KLTH0G01144g 255717619 8293348 complement(81486..83888) 1 NC_013083.1 similar to uniprot|P43612 Saccharomyces cerevisiae YFR040W; KLTH0G01144p 83888 8293348 KLTH0G01144g Lachancea thermotolerans CBS 6340 KLTH0G01144p XP_002555090.1 81486 R 559295 CDS KLTH0G01166g 255717621 8293349 84229..86250 1 NC_013083.1 weakly similar to uniprot|P53075 Saccharomyces cerevisiae YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function overexpression causes growth arrest; KLTH0G01166p 86250 8293349 KLTH0G01166g Lachancea thermotolerans CBS 6340 KLTH0G01166p XP_002555091.1 84229 D 559295 CDS KLTH0G01188g 255717623 8293350 86471..87820 1 NC_013083.1 highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S- adenosyl-L-methionine (AdoMet) to an acceptor; KLTH0G01188p 87820 8293350 KLTH0G01188g Lachancea thermotolerans CBS 6340 KLTH0G01188p XP_002555092.1 86471 D 559295 CDS KLTH0G01210g 255717625 8293351 88489..90960 1 NC_013083.1 weakly similar to uniprot|P53076 Saccharomyces cerevisiae YGL227W; KLTH0G01210p 90960 8293351 KLTH0G01210g Lachancea thermotolerans CBS 6340 KLTH0G01210p XP_002555093.1 88489 D 559295 CDS KLTH0G01232g 255717627 8293352 complement(join(91023..91268,91327..91350)) 1 NC_013083.1 similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; KLTH0G01232p 91350 8293352 KLTH0G01232g Lachancea thermotolerans CBS 6340 KLTH0G01232p XP_002555094.1 91023 R 559295 CDS KLTH0G01254g 255717629 8293353 91489..91938 1 NC_013083.1 similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W Hypothetical ORF; KLTH0G01254p 91938 8293353 KLTH0G01254g Lachancea thermotolerans CBS 6340 KLTH0G01254p XP_002555095.1 91489 D 559295 CDS KLTH0G01276g 255717631 8293354 complement(91956..92510) 1 NC_013083.1 highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Peptide methionine sulfoxide reductase reverses the oxidation of methionine residues involved in oxidative damage repair providing resistance to oxidative stress and regulation of lifespan; KLTH0G01276p 92510 8293354 KLTH0G01276g Lachancea thermotolerans CBS 6340 KLTH0G01276p XP_002555096.1 91956 R 559295 CDS KLTH0G01298g 255717633 8293355 complement(92808..94835) 1 NC_013083.1 similar to uniprot|P40028 Saccharomyces cerevisiae YER041W; KLTH0G01298p 94835 8293355 KLTH0G01298g Lachancea thermotolerans CBS 6340 KLTH0G01298p XP_002555097.1 92808 R 559295 CDS KLTH0G01320g 255717635 8293356 complement(95197..97431) 1 NC_013083.1 weakly similar to uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) localization and activity regulated by quality of nitrogen source; KLTH0G01320p 97431 8293356 KLTH0G01320g Lachancea thermotolerans CBS 6340 KLTH0G01320p XP_002555098.1 95197 R 559295 CDS KLTH0G01342g 255717637 8293357 98101..99108 1 NC_013083.1 similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W VRG4 May regulate Golgi function and glycosylation in Golgi Golgi GDP-mannose transporter; KLTH0G01342p 99108 8293357 KLTH0G01342g Lachancea thermotolerans CBS 6340 KLTH0G01342p XP_002555099.1 98101 D 559295 CDS KLTH0G01364g 255717639 8293358 join(99120..99191,99325..100518) 1 NC_013083.1 weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; KLTH0G01364p 100518 8293358 KLTH0G01364g Lachancea thermotolerans CBS 6340 KLTH0G01364p XP_002555100.1 99120 D 559295 CDS KLTH0G01386g 255717641 8293359 complement(100515..101414) 1 NC_013083.1 similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C SDT1 Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II as well as resistance to other pyrimidine derivatives or to YER037W uniprot|P40025 Saccharomyces cerevisiae YER037W PHM8; KLTH0G01386p 101414 8293359 KLTH0G01386g Lachancea thermotolerans CBS 6340 KLTH0G01386p XP_002555101.1 100515 R 559295 CDS KLTH0G01408g 255717643 8293360 complement(101521..103356) 1 NC_013083.1 weakly similar to uniprot|P53079 Saccharomyces cerevisiae YGL223C COG1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0G01408p 103356 8293360 KLTH0G01408g Lachancea thermotolerans CBS 6340 KLTH0G01408p XP_002555102.1 101521 R 559295 CDS KLTH0G01430g 255717645 8293361 complement(104505..105005) 1 NC_013083.1 no similarity; KLTH0G01430p 105005 8293361 KLTH0G01430g Lachancea thermotolerans CBS 6340 KLTH0G01430p XP_002555103.1 104505 R 559295 CDS KLTH0G01452g 255717647 8293362 105741..107564 1 NC_013083.1 highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C; KLTH0G01452p 107564 8293362 KLTH0G01452g Lachancea thermotolerans CBS 6340 KLTH0G01452p XP_002555104.1 105741 D 559295 CDS KLTH0G01474g 255717649 8293363 complement(108671..109738) 1 NC_013083.1 some similarities with uniprot|P53080 Saccharomyces cerevisiae YGL222C EDC1 RNA-binding protein activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; KLTH0G01474p 109738 8293363 KLTH0G01474g Lachancea thermotolerans CBS 6340 KLTH0G01474p XP_002555105.1 108671 R 559295 CDS KLTH0G01496g 255717651 8293364 complement(110060..110593) 1 NC_013083.1 conserved hypothetical protein; KLTH0G01496p 110593 8293364 KLTH0G01496g Lachancea thermotolerans CBS 6340 KLTH0G01496p XP_002555106.1 110060 R 559295 CDS KLTH0G01518g 255717653 8293365 complement(110693..111550) 1 NC_013083.1 similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C; KLTH0G01518p 111550 8293365 KLTH0G01518g Lachancea thermotolerans CBS 6340 KLTH0G01518p XP_002555107.1 110693 R 559295 CDS KLTH0G01540g 255717655 8293366 111703..111960 1 NC_013083.1 similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W Hypothetical ORF; KLTH0G01540p 111960 8293366 KLTH0G01540g Lachancea thermotolerans CBS 6340 KLTH0G01540p XP_002555108.1 111703 D 559295 CDS KLTH0G01562g 255717657 8293367 complement(112050..113678) 1 NC_013083.1 similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial outer membrane protein colocalizes with mtDNA nucleids required for mitochondria shape; KLTH0G01562p 113678 8293367 KLTH0G01562g Lachancea thermotolerans CBS 6340 KLTH0G01562p XP_002555109.1 112050 R 559295 CDS KLTH0G01584g 255717659 8293368 complement(114328..115530) 1 NC_013083.1 similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism; KLTH0G01584p 115530 8293368 KLTH0G01584g Lachancea thermotolerans CBS 6340 KLTH0G01584p XP_002555110.1 114328 R 559295 CDS KLTH0G01606g 255717661 8293369 116364..118823 1 NC_013083.1 similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning; KLTH0G01606p 118823 8293369 KLTH0G01606g Lachancea thermotolerans CBS 6340 KLTH0G01606p XP_002555111.1 116364 D 559295 CDS KLTH0G01628g 255717663 8293370 119662..120873 1 NC_013083.1 some similarities with uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography cyclin-like protein that interacts with Pho85; KLTH0G01628p 120873 8293370 KLTH0G01628g Lachancea thermotolerans CBS 6340 KLTH0G01628p XP_002555112.1 119662 D 559295 CDS KLTH0G01650g 255717665 8293371 complement(join(121279..122466,122554..122556)) 1 NC_013083.1 similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 essential for protection against viral cytopathology dispensable for mitotic but required for meiotic recombination and spore viability antiviral protein mRNA is induced early in meiosis; KLTH0G01650p 122556 8293371 KLTH0G01650g Lachancea thermotolerans CBS 6340 KLTH0G01650p XP_002555113.1 121279 R 559295 CDS KLTH0G01672g 255717667 8293372 122726..123775 1 NC_013083.1 similar to uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Regulator of vacuolar morphogenesis hydrophilic protein heptad repeat motif; KLTH0G01672p 123775 8293372 KLTH0G01672g Lachancea thermotolerans CBS 6340 KLTH0G01672p XP_002555114.1 122726 D 559295 CDS KLTH0G01694g 255717669 8293373 124053..125174 1 NC_013083.1 similar to uniprot|P53088 Saccharomyces cerevisiae YGL211W; KLTH0G01694p 125174 8293373 KLTH0G01694g Lachancea thermotolerans CBS 6340 KLTH0G01694p XP_002555115.1 124053 D 559295 CDS KLTH0G01716g 255717671 8293374 125972..128509 1 NC_013083.1 some similarities with uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency; KLTH0G01716p 128509 8293374 KLTH0G01716g Lachancea thermotolerans CBS 6340 KLTH0G01716p XP_002555116.1 125972 D 559295 CDS KLTH0G01738g 255717673 8293375 complement(128741..131494) 1 NC_013083.1 some similarities with uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing interacts with Ref2p potential Cdc28p substrate; KLTH0G01738p 131494 8293375 KLTH0G01738g Lachancea thermotolerans CBS 6340 KLTH0G01738p XP_002555117.1 128741 R 559295 CDS KLTH0G01760g 255717675 8293376 join(132121..132166,132307..132917) 1 NC_013083.1 highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31; KLTH0G01760p 132917 8293376 KLTH0G01760g Lachancea thermotolerans CBS 6340 KLTH0G01760p XP_002555118.1 132121 D 559295 CDS KLTH0G01782g 255717677 8293377 complement(132995..133435) 1 NC_013083.1 weakly similar to uniprot|P40019 Saccharomyces cerevisiae YER030W Hypothetical ORF; KLTH0G01782p 133435 8293377 KLTH0G01782g Lachancea thermotolerans CBS 6340 KLTH0G01782p XP_002555119.1 132995 R 559295 CDS KLTH0G01804g 255717679 8293378 133466..134044 1 NC_013083.1 weakly similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein; KLTH0G01804p 134044 8293378 KLTH0G01804g Lachancea thermotolerans CBS 6340 KLTH0G01804p XP_002555120.1 133466 D 559295 CDS KLTH0G01826g 255717681 8293379 135376..136299 1 NC_013083.1 some similarities with uniprot|P53035 Saccharomyces cerevisiae YGL209W MIG2 Protein containing zinc fingers involved in repression along with Mig1p of SUC2 (invertase) expression by high levels of glucose binds to Mig1p-binding sites in SUC2 promoter; KLTH0G01826p 136299 8293379 KLTH0G01826g Lachancea thermotolerans CBS 6340 KLTH0G01826p XP_002555121.1 135376 D 559295 CDS KLTH0G01848g 255717683 8293380 136780..138030 1 NC_013083.1 similar to uniprot|P34164 Saccharomyces cerevisiae YGL208W SIP2 Member of a family of proteins including Sip1p and Gal83p that interact with Snf1p and Snf4p and are involved in the response to glucose starvation component of Snf1 protein complex involved in response to glucose starvation and similar to YER027C uniprot|Q04739 Saccharomyces cerevisiae YER027C GAL83 One of three possible beta-subunits of the Snf1 kinase complex allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source contains glycogen-binding domain; KLTH0G01848p 138030 8293380 KLTH0G01848g Lachancea thermotolerans CBS 6340 KLTH0G01848p XP_002555122.1 136780 D 559295 CDS KLTH0G01870g 255717685 8293381 138361..141459 1 NC_013083.1 similar to uniprot|P32558 Saccharomyces cerevisiae YGL207W SPT16 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; KLTH0G01870p 141459 8293381 KLTH0G01870g Lachancea thermotolerans CBS 6340 KLTH0G01870p XP_002555123.1 138361 D 559295 CDS KLTH0G01892g 255717687 8293382 complement(142143..147116) 1 NC_013083.1 highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 vesicle coat protein presumed vesicle coat protein; KLTH0G01892p 147116 8293382 KLTH0G01892g Lachancea thermotolerans CBS 6340 KLTH0G01892p XP_002555124.1 142143 R 559295 CDS KLTH0G01914g 255717689 8293383 148464..150680 1 NC_013083.1 similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase involved in the fatty acid beta-oxidation pathway localized to the peroxisomal matrix; KLTH0G01914p 150680 8293383 KLTH0G01914g Lachancea thermotolerans CBS 6340 KLTH0G01914p XP_002555125.1 148464 D 559295 CDS KLTH0G01936g 255717691 8293384 151117..151929 1 NC_013083.1 similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 phosphatidylserine synthase; KLTH0G01936p 151929 8293384 KLTH0G01936g Lachancea thermotolerans CBS 6340 KLTH0G01936p XP_002555126.1 151117 D 559295 CDS KLTH0G01980g 255717693 8293386 complement(152313..154550) 1 NC_013083.1 similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor cleaves Lys and Arg residues from the C-terminus of peptides and proteins; KLTH0G01980p 154550 8293386 KLTH0G01980g Lachancea thermotolerans CBS 6340 KLTH0G01980p XP_002555127.1 152313 R 559295 CDS KLTH0G02002g 255717695 8293387 155219..156709 1 NC_013083.1 highly similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis; KLTH0G02002p 156709 8293387 KLTH0G02002g Lachancea thermotolerans CBS 6340 KLTH0G02002p XP_002555128.1 155219 D 559295 CDS KLTH0G02024g 255717697 8293388 complement(156778..158406) 1 NC_013083.1 similar to uniprot|P36035 Saccharomyces cerevisiae YKL217W and to gnl|GLV|KLLA0F10043g Kluyveromyces lactis KLLA0F10043g; KLTH0G02024p 158406 8293388 KLTH0G02024g Lachancea thermotolerans CBS 6340 KLTH0G02024p XP_002555129.1 156778 R 559295 CDS KLTH0G02046g 255717699 8293389 complement(158828..161563) 1 NC_013083.1 highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen activity is regulated by cyclic AMP-mediated phosphorylation expression is regulated by stress-response elements and by the HOG MAP kinase pathway; KLTH0G02046p 161563 8293389 KLTH0G02046g Lachancea thermotolerans CBS 6340 KLTH0G02046p XP_002555130.1 158828 R 559295 CDS KLTH0G02068g 255717701 8293390 complement(162461..165571) 1 NC_013083.1 similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; KLTH0G02068p 165571 8293390 KLTH0G02068g Lachancea thermotolerans CBS 6340 KLTH0G02068p XP_002555131.1 162461 R 559295 CDS KLTH0G02112g 255717703 8293392 complement(166538..168667) 1 NC_013083.1 similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p; KLTH0G02112p 168667 8293392 KLTH0G02112g Lachancea thermotolerans CBS 6340 KLTH0G02112p XP_002555132.1 166538 R 559295 CDS KLTH0G02156g 255717705 8293394 complement(169670..170752) 1 NC_013083.1 conserved hypothetical protein; KLTH0G02156p 170752 8293394 KLTH0G02156g Lachancea thermotolerans CBS 6340 KLTH0G02156p XP_002555133.1 169670 R 559295 CDS KLTH0G02200g 255717707 8293396 complement(171670..172959) 1 NC_013083.1 some similarities with uniprot|P53286 Saccharomyces cerevisiae YGR142W BTN2 Cytosolic coiled- coil protein that modulates arginine uptake interacts with Rhb1p possible role in mediating pH homeostasis between the vacuole and plasma membrane H( )-ATPase may have a role in intracellular protein trafficking; KLTH0G02200p 172959 8293396 KLTH0G02200g Lachancea thermotolerans CBS 6340 KLTH0G02200p XP_002555134.1 171670 R 559295 CDS KLTH0G02222g 255717709 8293397 complement(173533..174849) 1 NC_013083.1 similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W VPS62 and similar to uniprot|Q06466 Saccharomyces cerevisiae YPR157W Hypothetical ORF; KLTH0G02222p 174849 8293397 KLTH0G02222g Lachancea thermotolerans CBS 6340 KLTH0G02222p XP_002555135.1 173533 R 559295 CDS KLTH0G02244g 255717711 8293398 complement(175051..177507) 1 NC_013083.1 weakly similar to uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere Cbf2p also binds to the CDEII region possibly forming a different multimeric complex ubiquitinated in vivo; KLTH0G02244p 177507 8293398 KLTH0G02244g Lachancea thermotolerans CBS 6340 KLTH0G02244p XP_002555136.1 175051 R 559295 CDS KLTH0G02266g 255717713 8293399 178663..180597 1 NC_013083.1 highly similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein; KLTH0G02266p 180597 8293399 KLTH0G02266g Lachancea thermotolerans CBS 6340 KLTH0G02266p XP_002555137.1 178663 D 559295 CDS KLTH0G02288g 255717715 8293400 181647..182219 1 NC_013083.1 no similarity; KLTH0G02288p 182219 8293400 KLTH0G02288g Lachancea thermotolerans CBS 6340 KLTH0G02288p XP_002555138.1 181647 D 559295 CDS KLTH0G02310g 255717717 8293401 182450..184267 1 NC_013083.1 similar to uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase functions with Nca3p; KLTH0G02310p 184267 8293401 KLTH0G02310g Lachancea thermotolerans CBS 6340 KLTH0G02310p XP_002555139.1 182450 D 559295 CDS KLTH0G02332g 255717719 8293402 complement(184383..185084) 1 NC_013083.1 similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced; KLTH0G02332p 185084 8293402 KLTH0G02332g Lachancea thermotolerans CBS 6340 KLTH0G02332p XP_002555140.1 184383 R 559295 CDS KLTH0G02354g 255717721 8293403 complement(join(185220..185343,185400..185693,185765..185769)) 1 NC_013083.1 similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Hypothetical ORF; KLTH0G02354p 185769 8293403 KLTH0G02354g Lachancea thermotolerans CBS 6340 KLTH0G02354p XP_002555141.1 185220 R 559295 CDS KLTH0G02376g 255717723 8293404 complement(185961..186716) 1 NC_013083.1 highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 20S proteasome beta-type subunit the only nonessential 20S subunit; KLTH0G02376p 186716 8293404 KLTH0G02376g Lachancea thermotolerans CBS 6340 KLTH0G02376p XP_002555142.1 185961 R 559295 CDS KLTH0G02398g 255717725 8293405 186986..188374 1 NC_013083.1 similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C Hypothetical ORF; KLTH0G02398p 188374 8293405 KLTH0G02398g Lachancea thermotolerans CBS 6340 KLTH0G02398p XP_002555143.1 186986 D 559295 CDS KLTH0G02420g 255717727 8293406 complement(188767..189636) 1 NC_013083.1 similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W; KLTH0G02420p 189636 8293406 KLTH0G02420g Lachancea thermotolerans CBS 6340 KLTH0G02420p XP_002555144.1 188767 R 559295 CDS KLTH0G02442g 255717729 8293407 complement(189819..193160) 1 NC_013083.1 similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily- conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation; KLTH0G02442p 193160 8293407 KLTH0G02442g Lachancea thermotolerans CBS 6340 KLTH0G02442p XP_002555145.1 189819 R 559295 CDS KLTH0G02464g 255717731 8293408 194153..195133 1 NC_013083.1 similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; KLTH0G02464p 195133 8293408 KLTH0G02464g Lachancea thermotolerans CBS 6340 KLTH0G02464p XP_002555146.1 194153 D 559295 CDS KLTH0G02508g 255717733 8293410 complement(196658..197587) 1 NC_013083.1 similar to uniprot|P35202 YOR143C Saccharomyces cerevisiae THI80 Thiamine pyrophosphokinase; KLTH0G02508p 197587 8293410 KLTH0G02508g Lachancea thermotolerans CBS 6340 KLTH0G02508p XP_002555147.1 196658 R 559295 CDS KLTH0G02530g 255717735 8293411 197769..198761 1 NC_013083.1 similar to uniprot|P06844 YDR392W Saccharomyces cerevisiae SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; KLTH0G02530p 198761 8293411 KLTH0G02530g Lachancea thermotolerans CBS 6340 KLTH0G02530p XP_002555148.1 197769 D 559295 CDS KLTH0G02552g 255717737 8293412 complement(198794..201187) 1 NC_013083.1 some similarities with uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Protein required for S phase progression and telomere homeostasis; KLTH0G02552p 201187 8293412 KLTH0G02552g Lachancea thermotolerans CBS 6340 KLTH0G02552p XP_002555149.1 198794 R 559295 CDS KLTH0G02574g 255717739 8293413 complement(201390..202205) 1 NC_013083.1 similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability; KLTH0G02574p 202205 8293413 KLTH0G02574g Lachancea thermotolerans CBS 6340 KLTH0G02574p XP_002555150.1 201390 R 559295 CDS KLTH0G02596g 255717741 8293414 202425..204206 1 NC_013083.1 similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology; KLTH0G02596p 204206 8293414 KLTH0G02596g Lachancea thermotolerans CBS 6340 KLTH0G02596p XP_002555151.1 202425 D 559295 CDS KLTH0G02618g 255717743 8293415 complement(204285..204941) 1 NC_013083.1 some similarities with uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Required for final stages of splicesome maturation promotes step 1 of splicing spliceosome-associated protein; KLTH0G02618p 204941 8293415 KLTH0G02618g Lachancea thermotolerans CBS 6340 KLTH0G02618p XP_002555152.1 204285 R 559295 CDS KLTH0G02640g 255717745 8293416 205070..206398 1 NC_013083.1 similar to uniprot|Q04172 YDR393W Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology; KLTH0G02640p 206398 8293416 KLTH0G02640g Lachancea thermotolerans CBS 6340 KLTH0G02640p XP_002555153.1 205070 D 559295 CDS KLTH0G02662g 255717747 8293417 206550..207827 1 NC_013083.1 highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates substrate of N- acetyltransferase B; KLTH0G02662p 207827 8293417 KLTH0G02662g Lachancea thermotolerans CBS 6340 KLTH0G02662p XP_002555154.1 206550 D 559295 CDS KLTH0G02684g 255717749 8293418 complement(207890..209416) 1 NC_013083.1 similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure; KLTH0G02684p 209416 8293418 KLTH0G02684g Lachancea thermotolerans CBS 6340 KLTH0G02684p XP_002555155.1 207890 R 559295 CDS KLTH0G02706g 255717751 8293419 209656..212508 1 NC_013083.1 similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p; KLTH0G02706p 212508 8293419 KLTH0G02706g Lachancea thermotolerans CBS 6340 KLTH0G02706p XP_002555156.1 209656 D 559295 CDS KLTH0G02728g 255717753 8293420 complement(212646..213140) 1 NC_013083.1 highly similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2); KLTH0G02728p 213140 8293420 KLTH0G02728g Lachancea thermotolerans CBS 6340 KLTH0G02728p XP_002555157.1 212646 R 559295 CDS KLTH0G02750g 255717755 8293421 214405..214860 1 NC_013083.1 no similarity; KLTH0G02750p 214860 8293421 KLTH0G02750g Lachancea thermotolerans CBS 6340 KLTH0G02750p XP_002555158.1 214405 D 559295 CDS KLTH0G02772g 255717757 8293422 214898..216805 1 NC_013083.1 similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0G02772p 216805 8293422 KLTH0G02772g Lachancea thermotolerans CBS 6340 KLTH0G02772p XP_002555159.1 214898 D 559295 CDS KLTH0G02794g 255717759 8293423 217593..218237 1 NC_013083.1 highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome; KLTH0G02794p 218237 8293423 KLTH0G02794g Lachancea thermotolerans CBS 6340 KLTH0G02794p XP_002555160.1 217593 D 559295 CDS KLTH0G02816g 255717761 8293424 complement(219150..220559) 1 NC_013083.1 similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport; KLTH0G02816p 220559 8293424 KLTH0G02816g Lachancea thermotolerans CBS 6340 KLTH0G02816p XP_002555161.1 219150 R 559295 CDS KLTH0G02838g 255717763 8293425 221833..222288 1 NC_013083.1 no similarity; KLTH0G02838p 222288 8293425 KLTH0G02838g Lachancea thermotolerans CBS 6340 KLTH0G02838p XP_002555162.1 221833 D 559295 CDS KLTH0G02860g 255717765 8293426 222428..223459 1 NC_013083.1 similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase); KLTH0G02860p 223459 8293426 KLTH0G02860g Lachancea thermotolerans CBS 6340 KLTH0G02860p XP_002555163.1 222428 D 559295 CDS KLTH0G02882g 255717767 8293427 complement(223474..224994) 1 NC_013083.1 similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s; KLTH0G02882p 224994 8293427 KLTH0G02882g Lachancea thermotolerans CBS 6340 KLTH0G02882p XP_002555164.1 223474 R 559295 CDS KLTH0G02904g 255717769 8293428 225923..227479 1 NC_013083.1 similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor; KLTH0G02904p 227479 8293428 KLTH0G02904g Lachancea thermotolerans CBS 6340 KLTH0G02904p XP_002555165.1 225923 D 559295 CDS KLTH0G02926g 255717771 8293429 complement(227702..228217) 1 NC_013083.1 highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p; KLTH0G02926p 228217 8293429 KLTH0G02926g Lachancea thermotolerans CBS 6340 KLTH0G02926p XP_002555166.1 227702 R 559295 CDS KLTH0G02948g 255717773 8293430 228482..228964 1 NC_013083.1 highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit; KLTH0G02948p 228964 8293430 KLTH0G02948g Lachancea thermotolerans CBS 6340 KLTH0G02948p XP_002555167.1 228482 D 559295 CDS KLTH0G02970g 255717775 8293431 complement(229131..232793) 1 NC_013083.1 highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C RPB2 RNA polymerase II second largest subunit B150, part of central core; KLTH0G02970p 232793 8293431 KLTH0G02970g Lachancea thermotolerans CBS 6340 KLTH0G02970p XP_002555168.1 229131 R 559295 CDS KLTH0G02992g 255717777 8293432 232992..233831 1 NC_013083.1 similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit; KLTH0G02992p 233831 8293432 KLTH0G02992g Lachancea thermotolerans CBS 6340 KLTH0G02992p XP_002555169.1 232992 D 559295 CDS KLTH0G03014g 255717779 8293433 complement(233917..234399) 1 NC_013083.1 weakly similar to uniprot|Q99325 Saccharomyces cerevisiae YOR152C; KLTH0G03014p 234399 8293433 KLTH0G03014g Lachancea thermotolerans CBS 6340 KLTH0G03014p XP_002555170.1 233917 R 559295 CDS KLTH0G03036g 255717781 8293434 complement(234881..236179) 1 NC_013083.1 similar to uniprot|Q99312 YOR155C Saccharomyces cerevisiae ISN1 Inosine 5'-monophosphate (IMP)-specific 5'- nucleotidase; KLTH0G03036p 236179 8293434 KLTH0G03036g Lachancea thermotolerans CBS 6340 KLTH0G03036p XP_002555171.1 234881 R 559295 CDS KLTH0G03058g 255717783 8293435 237157..238761 1 NC_013083.1 similar to uniprot|Q12412 YOR161C Saccharomyces cerevisiae PNS1; KLTH0G03058p 238761 8293435 KLTH0G03058g Lachancea thermotolerans CBS 6340 KLTH0G03058p XP_002555172.1 237157 D 559295 CDS KLTH0G03080g 255717785 8293436 complement(238995..241895) 1 NC_013083.1 similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor mediates the nuclear localization of proteins involved in mRNA- nucleus export; KLTH0G03080p 241895 8293436 KLTH0G03080g Lachancea thermotolerans CBS 6340 KLTH0G03080p XP_002555173.1 238995 R 559295 CDS KLTH0G03102g 255717787 8293437 243531..243815 1 NC_013083.1 similar to uniprot|Q12330 YOR159C Saccharomyces cerevisiae SME1 Required for pre-mRNA splicing, cap modification and U1 U2 U4 and U5 snRNA stability; KLTH0G03102p 243815 8293437 KLTH0G03102g Lachancea thermotolerans CBS 6340 KLTH0G03102p XP_002555174.1 243531 D 559295 CDS KLTH0G03124g 255717789 8293438 complement(243931..244845) 1 NC_013083.1 similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit PET123 exhibits genetic interactions with PET122 which encodes a COX3 mRNA-specific translational activator; KLTH0G03124p 244845 8293438 KLTH0G03124g Lachancea thermotolerans CBS 6340 KLTH0G03124p XP_002555175.1 243931 R 559295 CDS KLTH0G03146g 255717791 8293439 complement(244963..248622) 1 NC_013083.1 similar to uniprot|Q04183 YDR407C Saccharomyces cerevisiae TRS120 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; KLTH0G03146p 248622 8293439 KLTH0G03146g Lachancea thermotolerans CBS 6340 KLTH0G03146p XP_002555176.1 244963 R 559295 CDS KLTH0G03168g 255717793 8293440 249621..250412 1 NC_013083.1 highly similar to uniprot|P25043 YOR157C Saccharomyces cerevisiae PUP1 Endopeptidase with trypsin- like activity that cleaves after basic residues; KLTH0G03168p 250412 8293440 KLTH0G03168g Lachancea thermotolerans CBS 6340 KLTH0G03168p XP_002555177.1 249621 D 559295 CDS KLTH0G03190g 255717795 8293441 complement(250460..251125) 1 NC_013083.1 similar to uniprot|P04161 YDR408C Saccharomyces cerevisiae ADE8 Phosphoribosyl-glycinamide transformylase; KLTH0G03190p 251125 8293441 KLTH0G03190g Lachancea thermotolerans CBS 6340 KLTH0G03190p XP_002555178.1 250460 R 559295 CDS KLTH0G03212g 255717797 8293442 251547..254195 1 NC_013083.1 weakly similar to Q04195 YDR409W uniprot|Q7LIJ4 Saccharomyces cerevisiae SIZ1 SUMO ligase that promotes the attachment of sumo (Smt3p small ubiquitin-related modifier) to proteins; KLTH0G03212p 254195 8293442 KLTH0G03212g Lachancea thermotolerans CBS 6340 KLTH0G03212p XP_002555179.1 251547 D 559295 CDS KLTH0G03234g 255717799 8293443 complement(254257..255051) 1 NC_013083.1 similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum localizes to the ER membrane; KLTH0G03234p 255051 8293443 KLTH0G03234g Lachancea thermotolerans CBS 6340 KLTH0G03234p XP_002555180.1 254257 R 559295 CDS KLTH0G03256g 255717801 8293444 complement(255316..256092) 1 NC_013083.1 similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting; KLTH0G03256p 256092 8293444 KLTH0G03256g Lachancea thermotolerans CBS 6340 KLTH0G03256p XP_002555181.1 255316 R 559295 CDS KLTH0G03300g 255717803 8293446 complement(256458..258407) 1 NC_013083.1 similar to uniprot|P32796 YML042W Saccharomyces cerevisiae CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes; KLTH0G03300p 258407 8293446 KLTH0G03300g Lachancea thermotolerans CBS 6340 KLTH0G03300p XP_002555182.1 256458 R 559295 CDS KLTH0G03322g 255717805 8293447 complement(258857..259906) 1 NC_013083.1 similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1; KLTH0G03322p 259906 8293447 KLTH0G03322g Lachancea thermotolerans CBS 6340 KLTH0G03322p XP_002555183.1 258857 R 559295 CDS KLTH0G03344g 255717807 8293448 260349..261050 1 NC_013083.1 similar to uniprot|Q04031 YDR412W Saccharomyces cerevisiae RRP17 Protein required for cell viability; KLTH0G03344p 261050 8293448 KLTH0G03344g Lachancea thermotolerans CBS 6340 KLTH0G03344p XP_002555184.1 260349 D 559295 CDS KLTH0G03366g 255717809 8293449 complement(261183..262337) 1 NC_013083.1 similar to uniprot|P16151 Saccharomyces cerevisiae YDR414C ERD1 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins mutants secrete the endogenous ER protein BiP (Kar2p); KLTH0G03366p 262337 8293449 KLTH0G03366g Lachancea thermotolerans CBS 6340 KLTH0G03366p XP_002555185.1 261183 R 559295 CDS KLTH0G03432g 255717811 8294192 complement(263388..265202) 1 NC_013083.1 similar to uniprot|Q04895 YIR028W Saccharomyces cerevisiae YIR028W DAL4 Allantoin permease; KLTH0G03432p 265202 8294192 KLTH0G03432g Lachancea thermotolerans CBS 6340 KLTH0G03432p XP_002555186.1 263388 R 559295 CDS KLTH0G03454g 255717813 8293451 complement(266490..268082) 1 NC_013083.1 weakly similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6; KLTH0G03454p 268082 8293451 KLTH0G03454g Lachancea thermotolerans CBS 6340 KLTH0G03454p XP_002555187.1 266490 R 559295 CDS KLTH0G03476g 255717815 8293452 269142..270296 1 NC_013083.1 similar to uniprot|P32611 YEL050C Saccharomyces cerevisiae RML2 Mitochondrial ribosomal protein of the large subunit; KLTH0G03476p 270296 8293452 KLTH0G03476g Lachancea thermotolerans CBS 6340 KLTH0G03476p XP_002555188.1 269142 D 559295 CDS KLTH0G03498g 255717817 8293453 complement(271089..271919) 1 NC_013083.1 highly similar to uniprot|P32610 YEL051W Saccharomyces cerevisiae VMA8 vacuolar ATPase V1 domain subunit D; KLTH0G03498p 271919 8293453 KLTH0G03498g Lachancea thermotolerans CBS 6340 KLTH0G03498p XP_002555189.1 271089 R 559295 CDS KLTH0G03520g 255717819 8293454 272176..274626 1 NC_013083.1 similar to uniprot|Q04048 Saccharomyces cerevisiae YDR416W CLF1 sssential splicesome assembly factor; KLTH0G03520p 274626 8293454 KLTH0G03520g Lachancea thermotolerans CBS 6340 KLTH0G03520p XP_002555190.1 272176 D 559295 CDS KLTH0G03586g 255717821 8293457 complement(275721..277586) 1 NC_013083.1 similar to uniprot|Q04049 YDR419W Saccharomyces cerevisiae RAD30 DNA polymerase eta involved in the predominantly error-free bypass replication of DNA lesions; KLTH0G03586p 277586 8293457 KLTH0G03586g Lachancea thermotolerans CBS 6340 KLTH0G03586p XP_002555191.1 275721 R 559295 CDS KLTH0G03608g 255717823 8293458 complement(277904..278785) 1 NC_013083.1 some similarities with uniprot|P31787 Saccharomyces cerevisiae YGR037C; KLTH0G03608p 278785 8293458 KLTH0G03608g Lachancea thermotolerans CBS 6340 KLTH0G03608p XP_002555192.1 277904 R 559295 CDS KLTH0G03630g 255717825 8293459 complement(279519..280016) 1 NC_013083.1 highly similar to uniprot|P17079 YEL054C Saccharomyces cerevisiae RPL12A and highly similar to uniprot|P17079 Saccharomyces cerevisiae YDR418W RPL12BProtein component of the large (60S) ribosomal subunit; KLTH0G03630p 280016 8293459 KLTH0G03630g Lachancea thermotolerans CBS 6340 KLTH0G03630p XP_002555193.1 279519 R 559295 CDS KLTH0G03652g 255717827 8293460 complement(280757..282958) 1 NC_013083.1 similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N- terminal acetyltransferase of the NatC type required for replication of dsRNA virus expression is glucose- repressible; KLTH0G03652p 282958 8293460 KLTH0G03652g Lachancea thermotolerans CBS 6340 KLTH0G03652p XP_002555194.1 280757 R 559295 CDS KLTH0G03674g 255717829 8293461 284125..285540 1 NC_013083.1 similar to uniprot|P32317 YEL052W Saccharomyces cerevisiae AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to mitochondria; KLTH0G03674p 285540 8293461 KLTH0G03674g Lachancea thermotolerans CBS 6340 KLTH0G03674p XP_002555195.1 284125 D 559295 CDS KLTH0G03696g 255717831 8293462 286341..292598 1 NC_013083.1 some similarities with uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif involved in the regulation of cell wall beta-1 3 glucan synthesis and bud site selection overexpression confers resistance to Hansenula mrakii killer toxin HM-1; KLTH0G03696p 292598 8293462 KLTH0G03696g Lachancea thermotolerans CBS 6340 KLTH0G03696p XP_002555196.1 286341 D 559295 CDS KLTH0G03718g 255717833 8293463 292858..295431 1 NC_013083.1 similar to uniprot|Q04052 Saccharomyces cerevisiae YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; KLTH0G03718p 295431 8293463 KLTH0G03718g Lachancea thermotolerans CBS 6340 KLTH0G03718p XP_002555197.1 292858 D 559295 CDS KLTH0G03740g 255717835 8293464 295985..297880 1 NC_013083.1 similar to uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function proposed to be involved in the RAS/cAMP signaling pathway; KLTH0G03740p 297880 8293464 KLTH0G03740g Lachancea thermotolerans CBS 6340 KLTH0G03740p XP_002555198.1 295985 D 559295 CDS KLTH0G03762g 255717837 8293465 complement(297935..300064) 1 NC_013083.1 similar to uniprot|P32578 Saccharomyces cerevisiae YDR422C SIP1 Alternate beta-subunit of the Snf1p kinase complex may confer substrate specificity vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions; KLTH0G03762p 300064 8293465 KLTH0G03762g Lachancea thermotolerans CBS 6340 KLTH0G03762p XP_002555199.1 297935 R 559295 CDS KLTH0G03784g 255717839 8293466 complement(300734..302443) 1 NC_013083.1 weakly similar to uniprot|P19880 YML007W Saccharomyces cerevisiae YAP1 bZip transcription factor required for oxidative stress tolerance; KLTH0G03784p 302443 8293466 KLTH0G03784g Lachancea thermotolerans CBS 6340 KLTH0G03784p XP_002555200.1 300734 R 559295 CDS KLTH0G03806g 255717841 8293467 304242..305396 1 NC_013083.1 highly similar to uniprot|P25087 YML008C Saccharomyces cerevisiae ERG6 Delta(24)-sterol C- methyltransferase; KLTH0G03806p 305396 8293467 KLTH0G03806g Lachancea thermotolerans CBS 6340 KLTH0G03806p XP_002555201.1 304242 D 559295 CDS KLTH0G03828g 255717843 8293468 306065..307747 1 NC_013083.1 weakly similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease, mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol; KLTH0G03828p 307747 8293468 KLTH0G03828g Lachancea thermotolerans CBS 6340 KLTH0G03828p XP_002555202.1 306065 D 559295 CDS KLTH0G03850g 255717845 8293469 308053..309474 1 NC_013083.1 some similarities with uniprot|P28742 Saccharomyces cerevisiae YBL063W; KLTH0G03850p 309474 8293469 KLTH0G03850g Lachancea thermotolerans CBS 6340 KLTH0G03850p XP_002555203.1 308053 D 559295 CDS KLTH0G03872g 255717847 8293470 complement(join(309507..309737,309800..309822,309895..309907)) 1 NC_013083.1 similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein; KLTH0G03872p 309907 8293470 KLTH0G03872g Lachancea thermotolerans CBS 6340 KLTH0G03872p XP_002555204.1 309507 R 559295 CDS KLTH0G03894g 255717849 8293471 310030..311811 1 NC_013083.1 similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes; KLTH0G03894p 311811 8293471 KLTH0G03894g Lachancea thermotolerans CBS 6340 KLTH0G03894p XP_002555205.1 310030 D 559295 CDS KLTH0G03916g 255717851 8293472 312025..313209 1 NC_013083.1 similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W; KLTH0G03916p 313209 8293472 KLTH0G03916g Lachancea thermotolerans CBS 6340 KLTH0G03916p XP_002555206.1 312025 D 559295 CDS KLTH0G03938g 255717853 8293473 complement(313277..314026) 1 NC_013083.1 similar to uniprot|Q04066 Saccharomyces cerevisiae YDR428C Hypothetical ORF; KLTH0G03938p 314026 8293473 KLTH0G03938g Lachancea thermotolerans CBS 6340 KLTH0G03938p XP_002555207.1 313277 R 559295 CDS KLTH0G03960g 255717855 8293474 complement(314167..315009) 1 NC_013083.1 similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3); KLTH0G03960p 315009 8293474 KLTH0G03960g Lachancea thermotolerans CBS 6340 KLTH0G03960p XP_002555208.1 314167 R 559295 CDS KLTH0G03982g 255717857 8293475 316270..316482 1 NC_013083.1 similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit; KLTH0G03982p 316482 8293475 KLTH0G03982g Lachancea thermotolerans CBS 6340 KLTH0G03982p XP_002555209.1 316270 D 559295 CDS KLTH0G04004g 255717859 8293476 complement(316665..319922) 1 NC_013083.1 similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; KLTH0G04004p 319922 8293476 KLTH0G04004g Lachancea thermotolerans CBS 6340 KLTH0G04004p XP_002555210.1 316665 R 559295 CDS KLTH0G04026g 255717861 8293477 complement(320835..321644) 1 NC_013083.1 weakly similar to uniprot|P53133 Saccharomyces cerevisiae YGL117W and gnl|GLV|KLLA0B00495g Kluyveromyces lactis KLLA0B00495g; KLTH0G04026p 321644 8293477 KLTH0G04026g Lachancea thermotolerans CBS 6340 KLTH0G04026p XP_002555211.1 320835 R 559295 CDS KLTH0G04048g 255717863 8293478 323588..324118 1 NC_013083.1 similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C Hypothetical ORF; KLTH0G04048p 324118 8293478 KLTH0G04048g Lachancea thermotolerans CBS 6340 KLTH0G04048p XP_002555212.1 323588 D 559295 CDS KLTH0G04070g 255717865 8293479 complement(324168..324797) 1 NC_013083.1 similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport; KLTH0G04070p 324797 8293479 KLTH0G04070g Lachancea thermotolerans CBS 6340 KLTH0G04070p XP_002555213.1 324168 R 559295 CDS KLTH0G04092g 255717867 8293480 complement(325076..328048) 1 NC_013083.1 similar to uniprot|P32898 YDR430C Saccharomyces cerevisiae CYM1 Cytosolic metalloprotease; KLTH0G04092p 328048 8293480 KLTH0G04092g Lachancea thermotolerans CBS 6340 KLTH0G04092p XP_002555214.1 325076 R 559295 CDS KLTH0G04114g 255717869 8293481 328845..330074 1 NC_013083.1 weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm; KLTH0G04114p 330074 8293481 KLTH0G04114g Lachancea thermotolerans CBS 6340 KLTH0G04114p XP_002555215.1 328845 D 559295 CDS KLTH0G04136g 255717871 8293482 complement(330648..332408) 1 NC_013083.1 similar to uniprot|Q04228 YML013W Saccharomyces cerevisiae SEL1 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p; KLTH0G04136p 332408 8293482 KLTH0G04136g Lachancea thermotolerans CBS 6340 KLTH0G04136p XP_002555216.1 330648 R 559295 CDS KLTH0G04158g 255717873 8293483 complement(332537..333367) 1 NC_013083.1 similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase; KLTH0G04158p 333367 8293483 KLTH0G04158g Lachancea thermotolerans CBS 6340 KLTH0G04158p XP_002555217.1 332537 R 559295 CDS KLTH0G04180g 255717875 8293484 333951..335507 1 NC_013083.1 similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; KLTH0G04180p 335507 8293484 KLTH0G04180g Lachancea thermotolerans CBS 6340 KLTH0G04180p XP_002555218.1 333951 D 559295 CDS KLTH0G04202g 255717877 8293485 335808..336875 1 NC_013083.1 similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation; KLTH0G04202p 336875 8293485 KLTH0G04202g Lachancea thermotolerans CBS 6340 KLTH0G04202p XP_002555219.1 335808 D 559295 CDS KLTH0G04224g 255717879 8293486 complement(336901..337896) 1 NC_013083.1 similar to uniprot|Q04081 YDR435C Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase; KLTH0G04224p 337896 8293486 KLTH0G04224g Lachancea thermotolerans CBS 6340 KLTH0G04224p XP_002555220.1 336901 R 559295 CDS KLTH0G04246g 255717881 8293487 338413..340404 1 NC_013083.1 similar to uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport; KLTH0G04246p 340404 8293487 KLTH0G04246g Lachancea thermotolerans CBS 6340 KLTH0G04246p XP_002555221.1 338413 D 559295 CDS KLTH0G04268g 255717883 8293488 340594..341034 1 NC_013083.1 similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability; KLTH0G04268p 341034 8293488 KLTH0G04268g Lachancea thermotolerans CBS 6340 KLTH0G04268p XP_002555222.1 340594 D 559295 CDS KLTH0G04290g 255717885 8293489 complement(341187..342656) 1 NC_013083.1 weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing; KLTH0G04290p 342656 8293489 KLTH0G04290g Lachancea thermotolerans CBS 6340 KLTH0G04290p XP_002555223.1 341187 R 559295 CDS KLTH0G04312g 255717887 8293490 343552..344778 1 NC_013083.1 similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae Hypothetical ORF; KLTH0G04312p 344778 8293490 KLTH0G04312g Lachancea thermotolerans CBS 6340 KLTH0G04312p XP_002555224.1 343552 D 559295 CDS KLTH0G04334g 255717889 8293491 complement(344829..345806) 1 NC_013083.1 similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W; KLTH0G04334p 345806 8293491 KLTH0G04334g Lachancea thermotolerans CBS 6340 KLTH0G04334p XP_002555225.1 344829 R 559295 CDS KLTH0G04356g 255717891 8293492 345922..346668 1 NC_013083.1 some similarities with uniprot|Q04087 Saccharomyces cerevisiae YDR439W; KLTH0G04356p 346668 8293492 KLTH0G04356g Lachancea thermotolerans CBS 6340 KLTH0G04356p XP_002555226.1 345922 D 559295 CDS KLTH0G04378g 255717893 8293493 complement(346716..348611) 1 NC_013083.1 similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae Hypothetical ORF; KLTH0G04378p 348611 8293493 KLTH0G04378g Lachancea thermotolerans CBS 6340 KLTH0G04378p XP_002555227.1 346716 R 559295 CDS KLTH0G04400g 255717895 8293494 348854..349879 1 NC_013083.1 similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase; KLTH0G04400p 349879 8293494 KLTH0G04400g Lachancea thermotolerans CBS 6340 KLTH0G04400p XP_002555228.1 348854 D 559295 CDS KLTH0G04422g 255717897 8293495 350035..351798 1 NC_013083.1 similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase; KLTH0G04422p 351798 8293495 KLTH0G04422g Lachancea thermotolerans CBS 6340 KLTH0G04422p XP_002555229.1 350035 D 559295 CDS KLTH0G04444g 255717899 8293496 complement(351969..352529) 1 NC_013083.1 highly similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase; KLTH0G04444p 352529 8293496 KLTH0G04444g Lachancea thermotolerans CBS 6340 KLTH0G04444p XP_002555230.1 351969 R 559295 CDS KLTH0G04466g 255717901 8293497 352698..354323 1 NC_013083.1 weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability; KLTH0G04466p 354323 8293497 KLTH0G04466g Lachancea thermotolerans CBS 6340 KLTH0G04466p XP_002555231.1 352698 D 559295 CDS KLTH0G04488g 255717903 8293498 complement(354359..358429) 1 NC_013083.1 similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p- Srb11p kinase with RNA polymerase holoenzyme; KLTH0G04488p 358429 8293498 KLTH0G04488g Lachancea thermotolerans CBS 6340 KLTH0G04488p XP_002555232.1 354359 R 559295 CDS KLTH0G04510g 255717905 8293499 358564..360450 1 NC_013083.1 similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W Hypothetical ORF; KLTH0G04510p 360450 8293499 KLTH0G04510g Lachancea thermotolerans CBS 6340 KLTH0G04510p XP_002555233.1 358564 D 559295 CDS KLTH0G04532g 255717907 8293500 complement(360504..362222) 1 NC_013083.1 similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane; KLTH0G04532p 362222 8293500 KLTH0G04532g Lachancea thermotolerans CBS 6340 KLTH0G04532p XP_002555234.1 360504 R 559295 CDS KLTH0G04554g 255717909 8293501 363047..363904 1 NC_013083.1 weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure; KLTH0G04554p 363904 8293501 KLTH0G04554g Lachancea thermotolerans CBS 6340 KLTH0G04554p XP_002555235.1 363047 D 559295 CDS KLTH0G04576g 255717911 8293502 complement(join(364039..364446,364742..364744)) 1 NC_013083.1 highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit; KLTH0G04576p 364744 8293502 KLTH0G04576g Lachancea thermotolerans CBS 6340 KLTH0G04576p XP_002555236.1 364039 R 559295 CDS KLTH0G04598g 255717913 8293503 365673..366980 1 NC_013083.1 highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes; KLTH0G04598p 366980 8293503 KLTH0G04598g Lachancea thermotolerans CBS 6340 KLTH0G04598p XP_002555237.1 365673 D 559295 CDS KLTH0G04620g 255717915 8293504 complement(367028..368365) 1 NC_013083.1 similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; KLTH0G04620p 368365 8293504 KLTH0G04620g Lachancea thermotolerans CBS 6340 KLTH0G04620p XP_002555238.1 367028 R 559295 CDS KLTH0G04642g 255717917 8293505 368885..369649 1 NC_013083.1 similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit; KLTH0G04642p 369649 8293505 KLTH0G04642g Lachancea thermotolerans CBS 6340 KLTH0G04642p XP_002555239.1 368885 D 559295 CDS KLTH0G04664g 255717919 8293506 join(370304..370350,370561..370954) 1 NC_013083.1 highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and highly similar to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit; KLTH0G04664p 370954 8293506 KLTH0G04664g Lachancea thermotolerans CBS 6340 KLTH0G04664p XP_002555240.1 370304 D 559295 CDS KLTH0G04686g 255717921 8293507 complement(371252..372379) 1 NC_013083.1 similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle- regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate; KLTH0G04686p 372379 8293507 KLTH0G04686g Lachancea thermotolerans CBS 6340 KLTH0G04686p XP_002555241.1 371252 R 559295 CDS KLTH0G04708g 255717923 8293508 373469..375484 1 NC_013083.1 similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer; KLTH0G04708p 375484 8293508 KLTH0G04708g Lachancea thermotolerans CBS 6340 KLTH0G04708p XP_002555242.1 373469 D 559295 CDS KLTH0G04730g 255717925 8293509 complement(375576..376166) 1 NC_013083.1 highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase; KLTH0G04730p 376166 8293509 KLTH0G04730g Lachancea thermotolerans CBS 6340 KLTH0G04730p XP_002555243.1 375576 R 559295 CDS KLTH0G04752g 255717927 8293510 complement(377984..380380) 1 NC_013083.1 similar to uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two- hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing; KLTH0G04752p 380380 8293510 KLTH0G04752g Lachancea thermotolerans CBS 6340 KLTH0G04752p XP_002555244.1 377984 R 559295 CDS KLTH0G04774g 255717929 8293511 complement(380741..381223) 1 NC_013083.1 similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W; KLTH0G04774p 381223 8293511 KLTH0G04774g Lachancea thermotolerans CBS 6340 KLTH0G04774p XP_002555245.1 380741 R 559295 CDS KLTH0G04796g 255717931 8293512 complement(381434..381991) 1 NC_013083.1 similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins; KLTH0G04796p 381991 8293512 KLTH0G04796g Lachancea thermotolerans CBS 6340 KLTH0G04796p XP_002555246.1 381434 R 559295 CDS KLTH0G04818g 255717933 8293513 383522..385360 1 NC_013083.1 similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger; KLTH0G04818p 385360 8293513 KLTH0G04818g Lachancea thermotolerans CBS 6340 KLTH0G04818p XP_002555247.1 383522 D 559295 CDS KLTH0G04840g 255717935 8293514 complement(385459..387246) 1 NC_013083.1 similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains; KLTH0G04840p 387246 8293514 KLTH0G04840g Lachancea thermotolerans CBS 6340 KLTH0G04840p XP_002555248.1 385459 R 559295 CDS KLTH0G04862g 255717937 8293515 387372..388811 1 NC_013083.1 similar to uniprot|P06778 Saccharomyces cerevisiae YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA anneals complementary single-stranded DNA involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis; KLTH0G04862p 388811 8293515 KLTH0G04862g Lachancea thermotolerans CBS 6340 KLTH0G04862p XP_002555249.1 387372 D 559295 CDS KLTH0G04884g 255717939 8293516 389220..398984 1 NC_013083.1 similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus; KLTH0G04884p 398984 8293516 KLTH0G04884g Lachancea thermotolerans CBS 6340 KLTH0G04884p XP_002555250.1 389220 D 559295 CDS KLTH0G04906g 255717941 8293517 complement(399246..399485) 1 NC_013083.1 conserved hypothetical protein; KLTH0G04906p 399485 8293517 KLTH0G04906g Lachancea thermotolerans CBS 6340 KLTH0G04906p XP_002555251.1 399246 R 559295 CDS KLTH0G04928g 255717943 8293518 complement(join(399807..400323,400504..402215)) 1 NC_013083.1 some similarities with uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1 Protein with a putative role in sister chromatid segregation potentially phosphorylated by Cdc28p green fluorescent protein (GFP)- fusion protein localizes to the nuclear periphery; KLTH0G04928p 402215 8293518 KLTH0G04928g Lachancea thermotolerans CBS 6340 KLTH0G04928p XP_002555252.1 399807 R 559295 CDS KLTH0G04950g 255717945 8293519 402472..404772 1 NC_013083.1 similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia may be involved in regulation of intracellular adenine nucleotide pools; KLTH0G04950p 404772 8293519 KLTH0G04950g Lachancea thermotolerans CBS 6340 KLTH0G04950p XP_002555253.1 402472 D 559295 CDS KLTH0G04972g 255717947 8293520 complement(404787..405890) 1 NC_013083.1 similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C likely functions in pathway(s) outside Ras; KLTH0G04972p 405890 8293520 KLTH0G04972g Lachancea thermotolerans CBS 6340 KLTH0G04972p XP_002555254.1 404787 R 559295 CDS KLTH0G04994g 255717949 8293521 406086..407054 1 NC_013083.1 highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W; KLTH0G04994p 407054 8293521 KLTH0G04994g Lachancea thermotolerans CBS 6340 KLTH0G04994p XP_002555255.1 406086 D 559295 CDS KLTH0G05016g 255717951 8293522 complement(407187..407651) 1 NC_013083.1 similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORF; KLTH0G05016p 407651 8293522 KLTH0G05016g Lachancea thermotolerans CBS 6340 KLTH0G05016p XP_002555256.1 407187 R 559295 CDS KLTH0G05038g 255717953 8293523 407809..408963 1 NC_013083.1 weakly similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C; KLTH0G05038p 408963 8293523 KLTH0G05038g Lachancea thermotolerans CBS 6340 KLTH0G05038p XP_002555257.1 407809 D 559295 CDS KLTH0G05060g 255717955 8293524 409563..410006 1 NC_013083.1 similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit; KLTH0G05060p 410006 8293524 KLTH0G05060g Lachancea thermotolerans CBS 6340 KLTH0G05060p XP_002555258.1 409563 D 559295 CDS KLTH0G05082g 255717957 8293525 410389..411501 1 NC_013083.1 similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C; KLTH0G05082p 411501 8293525 KLTH0G05082g Lachancea thermotolerans CBS 6340 KLTH0G05082p XP_002555259.1 410389 D 559295 CDS KLTH0G05104g 255717959 8293526 412304..413920 1 NC_013083.1 similar to uniprot|Q00947 Saccharomyces cerevisiae YDR463W STP1 and uniprot|P38704 Saccharomyces cerevisiae YHR006W STP2 Transcription factor; KLTH0G05104p 413920 8293526 KLTH0G05104g Lachancea thermotolerans CBS 6340 KLTH0G05104p XP_002555260.1 412304 D 559295 CDS KLTH0G05126g 255717961 8293527 414405..419042 1 NC_013083.1 some similarities with uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 appears to control expression of spliceosome components PRP4 and PRP3 negative regulator of prp genes; KLTH0G05126p 419042 8293527 KLTH0G05126g Lachancea thermotolerans CBS 6340 KLTH0G05126p XP_002555261.1 414405 D 559295 CDS KLTH0G05148g 255717963 8293528 complement(419176..420786) 1 NC_013083.1 highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase catalyzes the C-14 demethylation of lanosterol to form 4 4''-dimethyl cholesta-8 14 24-triene-3-beta-ol in the ergosterol biosynthesis pathway member of the cytochrome P450 family; KLTH0G05148p 420786 8293528 KLTH0G05148g Lachancea thermotolerans CBS 6340 KLTH0G05148p XP_002555262.1 419176 R 559295 CDS KLTH0G05170g 255717965 8293529 complement(421413..422624) 1 NC_013083.1 similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine methyltransferase ribosomal protein L12 is a substrate; KLTH0G05170p 422624 8293529 KLTH0G05170g Lachancea thermotolerans CBS 6340 KLTH0G05170p XP_002555263.1 421413 R 559295 CDS KLTH0G05192g 255717967 8293530 complement(422844..423530) 1 NC_013083.1 similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Manganese-containing superoxide dismutase; KLTH0G05192p 423530 8293530 KLTH0G05192g Lachancea thermotolerans CBS 6340 KLTH0G05192p XP_002555264.1 422844 R 559295 CDS KLTH0G05214g 255717969 8293531 423793..425754 1 NC_013083.1 weakly similar to uniprot|Q03306 Saccharomyces cerevisiae YDR466W; KLTH0G05214p 425754 8293531 KLTH0G05214g Lachancea thermotolerans CBS 6340 KLTH0G05214p XP_002555265.1 423793 D 559295 CDS KLTH0G05236g 255717971 8293532 complement(425913..427391) 1 NC_013083.1 similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C Hypothetical ORF; KLTH0G05236p 427391 8293532 KLTH0G05236g Lachancea thermotolerans CBS 6340 KLTH0G05236p XP_002555266.1 425913 R 559295 CDS KLTH0G05258g 255717973 8293533 complement(428402..429025) 1 NC_013083.1 similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 member of the syntaxin family of t- SNAREs tSNARE that affects a Late Golgi compartment; KLTH0G05258p 429025 8293533 KLTH0G05258g Lachancea thermotolerans CBS 6340 KLTH0G05258p XP_002555267.1 428402 R 559295 CDS KLTH0G05280g 255717975 8293534 429527..429799 1 NC_013083.1 some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W; KLTH0G05280p 429799 8293534 KLTH0G05280g Lachancea thermotolerans CBS 6340 KLTH0G05280p XP_002555268.1 429527 D 559295 CDS KLTH0G05302g 255717977 8293535 complement(429872..431287) 1 NC_013083.1 similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1; KLTH0G05302p 431287 8293535 KLTH0G05302g Lachancea thermotolerans CBS 6340 KLTH0G05302p XP_002555269.1 429872 R 559295 CDS KLTH0G05324g 255717979 8293536 complement(431556..432425) 1 NC_013083.1 conserved hypothetical protein; KLTH0G05324p 432425 8293536 KLTH0G05324g Lachancea thermotolerans CBS 6340 KLTH0G05324p XP_002555270.1 431556 R 559295 CDS KLTH0G05346g 255717981 8293537 join(433074..433104,433445..433824) 1 NC_013083.1 highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W RPL27A and to uniprot|P38706 Saccharomyces cerevisiae YDR471W RPL27B proteins component of the large (60S) ribosomal subunit; KLTH0G05346p 433824 8293537 KLTH0G05346g Lachancea thermotolerans CBS 6340 KLTH0G05346p XP_002555271.1 433074 D 559295 CDS KLTH0G05368g 255717983 8293538 434086..435414 1 NC_013083.1 similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase; KLTH0G05368p 435414 8293538 KLTH0G05368g Lachancea thermotolerans CBS 6340 KLTH0G05368p XP_002555272.1 434086 D 559295 CDS KLTH0G05390g 255717985 8293539 join(435603..435650,435707..436429) 1 NC_013083.1 similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Protein involved in vacuolar protein sorting; KLTH0G05390p 436429 8293539 KLTH0G05390g Lachancea thermotolerans CBS 6340 KLTH0G05390p XP_002555273.1 435603 D 559295 CDS KLTH0G05434g 255717987 8294185 complement(437130..437813) 1 NC_013083.1 similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing; KLTH0G05434p 437813 8294185 KLTH0G05434g Lachancea thermotolerans CBS 6340 KLTH0G05434p XP_002555274.1 437130 R 559295 CDS KLTH0G05456g 255717989 8293541 437841..438806 1 NC_013083.1 similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic; KLTH0G05456p 438806 8293541 KLTH0G05456g Lachancea thermotolerans CBS 6340 KLTH0G05456p XP_002555275.1 437841 D 559295 CDS KLTH0G05500g 255717991 8293543 440283..442022 1 NC_013083.1 weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Ada Histone acetyltransferase complex component protein of the Ada histone acetyltransferase complex; KLTH0G05500p 442022 8293543 KLTH0G05500g Lachancea thermotolerans CBS 6340 KLTH0G05500p XP_002555276.1 440283 D 559295 CDS KLTH0G05522g 255717993 8293544 442156..444135 1 NC_013083.1 similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Hypothetical ORF; KLTH0G05522p 444135 8293544 KLTH0G05522g Lachancea thermotolerans CBS 6340 KLTH0G05522p XP_002555277.1 442156 D 559295 CDS KLTH0G05544g 255717995 8293545 444244..444882 1 NC_013083.1 highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C; KLTH0G05544p 444882 8293545 KLTH0G05544g Lachancea thermotolerans CBS 6340 KLTH0G05544p XP_002555278.1 444244 D 559295 CDS KLTH0G05566g 255717997 8293546 complement(join(444962..445151,445380..445453)) 1 NC_013083.1 conserved hypothetical protein; KLTH0G05566p 445453 8293546 KLTH0G05566g Lachancea thermotolerans CBS 6340 KLTH0G05566p XP_002555279.1 444962 R 559295 CDS KLTH0G05588g 255717999 8293547 446144..446461 1 NC_013083.1 highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co- chaperonin that inhibits the ATPase activity of Hsp60p; KLTH0G05588p 446461 8293547 KLTH0G05588g Lachancea thermotolerans CBS 6340 KLTH0G05588p XP_002555280.1 446144 D 559295 CDS KLTH0G05610g 255718001 8293548 complement(446541..447809) 1 NC_013083.1 similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor component of the U4/U6-U5 snRNP complex; KLTH0G05610p 447809 8293548 KLTH0G05610g Lachancea thermotolerans CBS 6340 KLTH0G05610p XP_002555281.1 446541 R 559295 CDS KLTH0G05632g 255718003 8293549 complement(447986..450211) 1 NC_013083.1 some similarities with uniprot|Q99248 Saccharomyces cerevisiae YOR019W; KLTH0G05632p 450211 8293549 KLTH0G05632g Lachancea thermotolerans CBS 6340 KLTH0G05632p XP_002555282.1 447986 R 559295 CDS KLTH0G05654g 255718005 8293550 complement(join(450410..451090,451167..451244)) 1 NC_013083.1 conserved hypothetical protein; KLTH0G05654p 451244 8293550 KLTH0G05654g Lachancea thermotolerans CBS 6340 KLTH0G05654p XP_002555283.1 450410 R 559295 CDS KLTH0G05676g 255718007 8293551 complement(451458..452087) 1 NC_013083.1 similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Hypothetical ORF; KLTH0G05676p 452087 8293551 KLTH0G05676g Lachancea thermotolerans CBS 6340 KLTH0G05676p XP_002555284.1 451458 R 559295 CDS KLTH0G05698g 255718009 8293552 453530..455323 1 NC_013083.1 similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 Protein serine/threonine kinase required for release from glucose repression invertase expression sporulation and for expression of catabolite- repressed genes when glucose is limiting regulates Adr1p- dependent transcription primarily at the level of chromatin binding; KLTH0G05698p 455323 8293552 KLTH0G05698g Lachancea thermotolerans CBS 6340 KLTH0G05698p XP_002555285.1 453530 D 559295 CDS KLTH0G05720g 255718011 8293553 455630..457123 1 NC_013083.1 similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst4p in telomeric silencing cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism; KLTH0G05720p 457123 8293553 KLTH0G05720g Lachancea thermotolerans CBS 6340 KLTH0G05720p XP_002555286.1 455630 D 559295 CDS KLTH0G05742g 255718013 8293554 complement(457246..458775) 1 NC_013083.1 conserved hypothetical protein; KLTH0G05742p 458775 8293554 KLTH0G05742g Lachancea thermotolerans CBS 6340 KLTH0G05742p XP_002555287.1 457246 R 559295 CDS KLTH0G05764g 255718015 8293555 459416..459970 1 NC_013083.1 no similarity; KLTH0G05764p 459970 8293555 KLTH0G05764g Lachancea thermotolerans CBS 6340 KLTH0G05764p XP_002555288.1 459416 D 559295 CDS KLTH0G05786g 255718017 8293556 complement(460135..460995) 1 NC_013083.1 highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W; KLTH0G05786p 460995 8293556 KLTH0G05786g Lachancea thermotolerans CBS 6340 KLTH0G05786p XP_002555289.1 460135 R 559295 CDS KLTH0G05808g 255718019 8293557 complement(461330..462355) 1 NC_013083.1 highly similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization; KLTH0G05808p 462355 8293557 KLTH0G05808g Lachancea thermotolerans CBS 6340 KLTH0G05808p XP_002555290.1 461330 R 559295 CDS KLTH0G05830g 255718021 8293558 complement(join(462889..463165,463566..463567)) 1 NC_013083.1 highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W RPL43A Protein and to YJR094W-A uniprot|P49631 Saccharomyces cerevisiae YJR094W-A RPL43B Protein, components of the large (60S) ribosomal subunit; KLTH0G05830p 463567 8293558 KLTH0G05830g Lachancea thermotolerans CBS 6340 KLTH0G05830p XP_002555291.1 462889 R 559295 CDS KLTH0G05874g 255718023 8293560 464597..465337 1 NC_013083.1 conserved hypothetical protein; KLTH0G05874p 465337 8293560 KLTH0G05874g Lachancea thermotolerans CBS 6340 KLTH0G05874p XP_002555292.1 464597 D 559295 CDS KLTH0G05896g 255718025 8293561 465707..466480 1 NC_013083.1 similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit; KLTH0G05896p 466480 8293561 KLTH0G05896g Lachancea thermotolerans CBS 6340 KLTH0G05896p XP_002555293.1 465707 D 559295 CDS KLTH0G05918g 255718027 8293562 466729..467355 1 NC_013083.1 similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N- terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER; KLTH0G05918p 467355 8293562 KLTH0G05918g Lachancea thermotolerans CBS 6340 KLTH0G05918p XP_002555294.1 466729 D 559295 CDS KLTH0G05940g 255718029 8293563 467678..468493 1 NC_013083.1 conserved hypothetical protein; KLTH0G05940p 468493 8293563 KLTH0G05940g Lachancea thermotolerans CBS 6340 KLTH0G05940p XP_002555295.1 467678 D 559295 CDS KLTH0G05962g 255718031 8293564 complement(468537..469193) 1 NC_013083.1 similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog ; GPI11 ER membrane protein; KLTH0G05962p 469193 8293564 KLTH0G05962g Lachancea thermotolerans CBS 6340 KLTH0G05962p XP_002555296.1 468537 R 559295 CDS KLTH0G05984g 255718033 8293565 complement(469719..473642) 1 NC_013083.1 similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I); KLTH0G05984p 473642 8293565 KLTH0G05984g Lachancea thermotolerans CBS 6340 KLTH0G05984p XP_002555297.1 469719 R 559295 CDS KLTH0G06006g 255718035 8293566 474346..475611 1 NC_013083.1 similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF; KLTH0G06006p 475611 8293566 KLTH0G06006g Lachancea thermotolerans CBS 6340 KLTH0G06006p XP_002555298.1 474346 D 559295 CDS KLTH0G06028g 255718037 8293567 complement(475975..477033) 1 NC_013083.1 similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p); KLTH0G06028p 477033 8293567 KLTH0G06028g Lachancea thermotolerans CBS 6340 KLTH0G06028p XP_002555299.1 475975 R 559295 CDS KLTH0G06050g 255718039 8293568 complement(478755..480350) 1 NC_013083.1 similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A; KLTH0G06050p 480350 8293568 KLTH0G06050g Lachancea thermotolerans CBS 6340 KLTH0G06050p XP_002555300.1 478755 R 559295 CDS KLTH0G06072g 255718041 8293569 480649..481269 1 NC_013083.1 similar to uniprot|P09457 Saccharomyces cerevisiae YDR298C ATP5 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); KLTH0G06072p 481269 8293569 KLTH0G06072g Lachancea thermotolerans CBS 6340 KLTH0G06072p XP_002555301.1 480649 D 559295 CDS KLTH0G06094g 255718043 8293570 complement(481476..482489) 1 NC_013083.1 similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine; KLTH0G06094p 482489 8293570 KLTH0G06094g Lachancea thermotolerans CBS 6340 KLTH0G06094p XP_002555302.1 481476 R 559295 CDS KLTH0G06116g 255718045 8293571 complement(482874..483518) 1 NC_013083.1 similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning; KLTH0G06116p 483518 8293571 KLTH0G06116g Lachancea thermotolerans CBS 6340 KLTH0G06116p XP_002555303.1 482874 R 559295 CDS KLTH0G06138g 255718047 8293572 483715..485712 1 NC_013083.1 weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF; KLTH0G06138p 485712 8293572 KLTH0G06138g Lachancea thermotolerans CBS 6340 KLTH0G06138p XP_002555304.1 483715 D 559295 CDS KLTH0G06160g 255718049 8293573 485950..487806 1 NC_013083.1 similar to uniprot|Q06629 Saccharomyces cerevisiae YDR295C; KLTH0G06160p 487806 8293573 KLTH0G06160g Lachancea thermotolerans CBS 6340 KLTH0G06160p XP_002555305.1 485950 D 559295 CDS KLTH0G06182g 255718051 8293574 488096..489781 1 NC_013083.1 similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate; KLTH0G06182p 489781 8293574 KLTH0G06182g Lachancea thermotolerans CBS 6340 KLTH0G06182p XP_002555306.1 488096 D 559295 CDS KLTH0G06204g 255718053 8293575 490065..491297 1 NC_013083.1 similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability; KLTH0G06204p 491297 8293575 KLTH0G06204g Lachancea thermotolerans CBS 6340 KLTH0G06204p XP_002555307.1 490065 D 559295 CDS KLTH0G06226g 255718055 8293576 491936..493657 1 NC_013083.1 highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase; KLTH0G06226p 493657 8293576 KLTH0G06226g Lachancea thermotolerans CBS 6340 KLTH0G06226p XP_002555308.1 491936 D 559295 CDS KLTH0G06248g 255718057 8293577 494464..498141 1 NC_013083.1 similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence; KLTH0G06248p 498141 8293577 KLTH0G06248g Lachancea thermotolerans CBS 6340 KLTH0G06248p XP_002555309.1 494464 D 559295 CDS KLTH0G06270g 255718059 8293578 498404..499123 1 NC_013083.1 similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor; KLTH0G06270p 499123 8293578 KLTH0G06270g Lachancea thermotolerans CBS 6340 KLTH0G06270p XP_002555310.1 498404 D 559295 CDS KLTH0G06292g 255718061 8293579 complement(499189..501111) 1 NC_013083.1 similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids; KLTH0G06292p 501111 8293579 KLTH0G06292g Lachancea thermotolerans CBS 6340 KLTH0G06292p XP_002555311.1 499189 R 559295 CDS KLTH0G06314g 255718063 8293580 complement(join(501371..501712,501805..501807)) 1 NC_013083.1 similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector; KLTH0G06314p 501807 8293580 KLTH0G06314g Lachancea thermotolerans CBS 6340 KLTH0G06314p XP_002555312.1 501371 R 559295 CDS KLTH0G06336g 255718065 8293581 502078..503202 1 NC_013083.1 similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA; KLTH0G06336p 503202 8293581 KLTH0G06336g Lachancea thermotolerans CBS 6340 KLTH0G06336p XP_002555313.1 502078 D 559295 CDS KLTH0G06358g 255718067 8293582 complement(503325..504866) 1 NC_013083.1 weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; KLTH0G06358p 504866 8293582 KLTH0G06358g Lachancea thermotolerans CBS 6340 KLTH0G06358p XP_002555314.1 503325 R 559295 CDS KLTH0G06380g 255718069 8293583 505411..507171 1 NC_013083.1 similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP- dependent protein targeting interacts with SRP102p; KLTH0G06380p 507171 8293583 KLTH0G06380g Lachancea thermotolerans CBS 6340 KLTH0G06380p XP_002555315.1 505411 D 559295 CDS KLTH0G06402g 255718071 8293584 complement(507209..510427) 1 NC_013083.1 highly similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF; KLTH0G06402p 510427 8293584 KLTH0G06402g Lachancea thermotolerans CBS 6340 KLTH0G06402p XP_002555316.1 507209 R 559295 CDS KLTH0G06424g 255718073 8293585 510561..511622 1 NC_013083.1 similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition; KLTH0G06424p 511622 8293585 KLTH0G06424g Lachancea thermotolerans CBS 6340 KLTH0G06424p XP_002555317.1 510561 D 559295 CDS KLTH0G06446g 255718075 8293586 complement(join(511652..512279,512351..512361)) 1 NC_013083.1 similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit; KLTH0G06446p 512361 8293586 KLTH0G06446g Lachancea thermotolerans CBS 6340 KLTH0G06446p XP_002555318.1 511652 R 559295 CDS KLTH0G06468g 255718077 8293587 complement(513119..518251) 1 NC_013083.1 similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha- subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; KLTH0G06468p 518251 8293587 KLTH0G06468g Lachancea thermotolerans CBS 6340 KLTH0G06468p XP_002555319.1 513119 R 559295 CDS KLTH0G06490g 255718079 8293588 complement(518510..519388) 1 NC_013083.1 similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc-regulated vacuolar membrane- associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism; KLTH0G06490p 519388 8293588 KLTH0G06490g Lachancea thermotolerans CBS 6340 KLTH0G06490p XP_002555320.1 518510 R 559295 CDS KLTH0G06534g 255718081 8293590 complement(522210..522536) 1 NC_013083.1 similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF; KLTH0G06534p 522536 8293590 KLTH0G06534g Lachancea thermotolerans CBS 6340 KLTH0G06534p XP_002555321.1 522210 R 559295 CDS KLTH0G06556g 255718083 8293591 523037..523927 1 NC_013083.1 similar to Saccharomyces cerevisiae YDR287W inositol monophosphatase and to YHR046C uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; KLTH0G06556p 523927 8293591 KLTH0G06556g Lachancea thermotolerans CBS 6340 KLTH0G06556p XP_002555322.1 523037 D 559295 CDS KLTH0G06578g 255718085 8293592 524220..525146 1 NC_013083.1 similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential protein of unknown function; KLTH0G06578p 525146 8293592 KLTH0G06578g Lachancea thermotolerans CBS 6340 KLTH0G06578p XP_002555323.1 524220 D 559295 CDS KLTH0G06600g 255718087 8293593 525647..527719 1 NC_013083.1 similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase involved in ergosterol biosynthesis associated and coordinately regulated with Erg11p; KLTH0G06600p 527719 8293593 KLTH0G06600g Lachancea thermotolerans CBS 6340 KLTH0G06600p XP_002555324.1 525647 D 559295 CDS KLTH0G06622g 255718089 8293594 527870..529048 1 NC_013083.1 similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF; KLTH0G06622p 529048 8293594 KLTH0G06622g Lachancea thermotolerans CBS 6340 KLTH0G06622p XP_002555325.1 527870 D 559295 CDS KLTH0G06644g 255718091 8293595 complement(530734..531651) 1 NC_013083.1 highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'- >5' exonucleases; KLTH0G06644p 531651 8293595 KLTH0G06644g Lachancea thermotolerans CBS 6340 KLTH0G06644p XP_002555326.1 530734 R 559295 CDS KLTH0G06666g 255718093 8293596 complement(532420..533409) 1 NC_013083.1 similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity; KLTH0G06666p 533409 8293596 KLTH0G06666g Lachancea thermotolerans CBS 6340 KLTH0G06666p XP_002555327.1 532420 R 559295 CDS KLTH0G06688g 255718095 8293597 533755..535428 1 NC_013083.1 similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF; KLTH0G06688p 535428 8293597 KLTH0G06688g Lachancea thermotolerans CBS 6340 KLTH0G06688p XP_002555328.1 533755 D 559295 CDS KLTH0G06710g 255718097 8293598 complement(535474..536352) 1 NC_013083.1 highly similar to uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase involved in biosynthesis of inositol and in phosphoinositide second messenger signaling INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate; KLTH0G06710p 536352 8293598 KLTH0G06710g Lachancea thermotolerans CBS 6340 KLTH0G06710p XP_002555329.1 535474 R 559295 CDS KLTH0G06732g 255718099 8293599 complement(536547..539135) 1 NC_013083.1 highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase; KLTH0G06732p 539135 8293599 KLTH0G06732g Lachancea thermotolerans CBS 6340 KLTH0G06732p XP_002555330.1 536547 R 559295 CDS KLTH0G06754g 255718101 8293600 541019..542461 1 NC_013083.1 similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W Hypothetical ORF; KLTH0G06754p 542461 8293600 KLTH0G06754g Lachancea thermotolerans CBS 6340 KLTH0G06754p XP_002555331.1 541019 D 559295 CDS KLTH0G06776g 255718103 8293601 543396..544106 1 NC_013083.1 highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W; KLTH0G06776p 544106 8293601 KLTH0G06776g Lachancea thermotolerans CBS 6340 KLTH0G06776p XP_002555332.1 543396 D 559295 CDS KLTH0G06798g 255718105 8293602 544397..545965 1 NC_013083.1 similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter; KLTH0G06798p 545965 8293602 KLTH0G06798g Lachancea thermotolerans CBS 6340 KLTH0G06798p XP_002555333.1 544397 D 559295 CDS KLTH0G06820g 255718107 8293603 546219..546851 1 NC_013083.1 similar to uniprot|P36054 Saccharomyces cerevisiae YKL159C; KLTH0G06820p 546851 8293603 KLTH0G06820g Lachancea thermotolerans CBS 6340 KLTH0G06820p XP_002555334.1 546219 D 559295 CDS KLTH0G06842g 255718109 8293604 547158..547610 1 NC_013083.1 similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain expression is regulated by oxygen levels; KLTH0G06842p 547610 8293604 KLTH0G06842g Lachancea thermotolerans CBS 6340 KLTH0G06842p XP_002555335.1 547158 D 559295 CDS KLTH0G06864g 255718111 8293605 complement(547911..548354) 1 NC_013083.1 similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Protein of unknown function deletion inhibits Brome mosaic virus expression; KLTH0G06864p 548354 8293605 KLTH0G06864g Lachancea thermotolerans CBS 6340 KLTH0G06864p XP_002555336.1 547911 R 559295 CDS KLTH0G06886g 255718113 8293606 548680..549906 1 NC_013083.1 similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Core interacting component 1 ribosome biogenesis protein; KLTH0G06886p 549906 8293606 KLTH0G06886g Lachancea thermotolerans CBS 6340 KLTH0G06886p XP_002555337.1 548680 D 559295 CDS KLTH0G06908g 255718115 8293607 550439..551524 1 NC_013083.1 conserved hypothetical protein; KLTH0G06908p 551524 8293607 KLTH0G06908g Lachancea thermotolerans CBS 6340 KLTH0G06908p XP_002555338.1 550439 D 559295 CDS KLTH0G06930g 255718117 8293608 complement(551719..553536) 1 NC_013083.1 similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF; KLTH0G06930p 553536 8293608 KLTH0G06930g Lachancea thermotolerans CBS 6340 KLTH0G06930p XP_002555339.1 551719 R 559295 CDS KLTH0G06952g 255718119 8293609 553981..556062 1 NC_013083.1 similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition structurally and functionally related to Pif1p; KLTH0G06952p 556062 8293609 KLTH0G06952g Lachancea thermotolerans CBS 6340 KLTH0G06952p XP_002555340.1 553981 D 559295 CDS KLTH0G06974g 255718121 8293610 556626..558125 1 NC_013083.1 highly similar to uniprot|Q00772 Saccharomyces cerevisiae YHR030C SLT2 Suppressor of lyt2 serine/threonine MAP kinase; KLTH0G06974p 558125 8293610 KLTH0G06974g Lachancea thermotolerans CBS 6340 KLTH0G06974p XP_002555341.1 556626 D 559295 CDS KLTH0G06996g 255718123 8293611 558369..559241 1 NC_013083.1 similar to uniprot|P38765 Saccharomyces cerevisiae YHR029C Hypothetical ORF; KLTH0G06996p 559241 8293611 KLTH0G06996g Lachancea thermotolerans CBS 6340 KLTH0G06996p XP_002555342.1 558369 D 559295 CDS KLTH0G07018g 255718125 8293612 559864..562326 1 NC_013083.1 similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C; KLTH0G07018p 562326 8293612 KLTH0G07018g Lachancea thermotolerans CBS 6340 KLTH0G07018p XP_002555343.1 559864 D 559295 CDS KLTH0G07040g 255718127 8293613 562722..565646 1 NC_013083.1 similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain a site for protein? protein interactions; KLTH0G07040p 565646 8293613 KLTH0G07040g Lachancea thermotolerans CBS 6340 KLTH0G07040p XP_002555344.1 562722 D 559295 CDS KLTH0G07062g 255718129 8293614 complement(565809..566447) 1 NC_013083.1 similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole; KLTH0G07062p 566447 8293614 KLTH0G07062g Lachancea thermotolerans CBS 6340 KLTH0G07062p XP_002555345.1 565809 R 559295 CDS KLTH0G07084g 255718131 8293615 complement(566748..567821) 1 NC_013083.1 highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 homoserine kinase; KLTH0G07084p 567821 8293615 KLTH0G07084g Lachancea thermotolerans CBS 6340 KLTH0G07084p XP_002555346.1 566748 R 559295 CDS KLTH0G07106g 255718133 8293616 568012..569487 1 NC_013083.1 similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; KLTH0G07106p 569487 8293616 KLTH0G07106g Lachancea thermotolerans CBS 6340 KLTH0G07106p XP_002555347.1 568012 D 559295 CDS KLTH0G07128g 255718135 8293617 complement(569563..575151) 1 NC_013083.1 similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain required for wild- type cytokinesis and cell separation localizes to the actomyosin ring binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively; KLTH0G07128p 575151 8293617 KLTH0G07128g Lachancea thermotolerans CBS 6340 KLTH0G07128p XP_002555348.1 569563 R 559295 CDS KLTH0G07150g 255718137 8293618 575971..577893 1 NC_013083.1 conserved hypothetical protein; KLTH0G07150p 577893 8293618 KLTH0G07150g Lachancea thermotolerans CBS 6340 KLTH0G07150p XP_002555349.1 575971 D 559295 CDS KLTH0G07172g 255718139 8293619 578557..579714 1 NC_013083.1 some similarities with uniprot|P01120 Saccharomyces cerevisiae YNL098c; KLTH0G07172p 579714 8293619 KLTH0G07172g Lachancea thermotolerans CBS 6340 KLTH0G07172p XP_002555350.1 578557 D 559295 CDS KLTH0G07194g 255718141 8293620 complement(579918..580442) 1 NC_013083.1 no similarity; KLTH0G07194p 580442 8293620 KLTH0G07194g Lachancea thermotolerans CBS 6340 KLTH0G07194p XP_002555351.1 579918 R 559295 CDS KLTH0G07216g 255718143 8293621 join(581090..581092,581561..581806) 1 NC_013083.1 highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021c RPS27B ribosomal protein and to uniprot|P35997 Saccharomyces cerevisiae YKL156w RPS27A, Protein component of the small (40S) ribosomal subunit; KLTH0G07216p 581806 8293621 KLTH0G07216g Lachancea thermotolerans CBS 6340 KLTH0G07216p XP_002555352.1 581090 D 559295 CDS KLTH0G07238g 255718145 8293622 complement(582101..584224) 1 NC_013083.1 similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit; KLTH0G07238p 584224 8293622 KLTH0G07238g Lachancea thermotolerans CBS 6340 KLTH0G07238p XP_002555353.1 582101 R 559295 CDS KLTH0G07260g 255718147 8293623 join(584359..584541,584609..585205) 1 NC_013083.1 similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit involved in SRP-dependent protein targeting anchors Srp101p to the ER membrane; KLTH0G07260p 585205 8293623 KLTH0G07260g Lachancea thermotolerans CBS 6340 KLTH0G07260p XP_002555354.1 584359 D 559295 CDS KLTH0G07304g 255718149 8293625 585983..591001 1 NC_013083.1 similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC) localizes to the nuclear periphery of nuclear pores homologous to human p205; KLTH0G07304p 591001 8293625 KLTH0G07304g Lachancea thermotolerans CBS 6340 KLTH0G07304p XP_002555355.1 585983 D 559295 CDS KLTH0G07326g 255718151 8293626 complement(join(591049..593741,593816)) 1 NC_013083.1 similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export; KLTH0G07326p 593816 8293626 KLTH0G07326g Lachancea thermotolerans CBS 6340 KLTH0G07326p XP_002555356.1 591049 R 559295 CDS KLTH0G07348g 255718153 8293627 complement(594100..598065) 1 NC_013083.1 similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; KLTH0G07348p 598065 8293627 KLTH0G07348g Lachancea thermotolerans CBS 6340 KLTH0G07348p XP_002555357.1 594100 R 559295 CDS KLTH0G07370g 255718155 8293628 598519..599649 1 NC_013083.1 weakly similar to uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member Ypt6p involved in vesicle mediated protein transport; KLTH0G07370p 599649 8293628 KLTH0G07370g Lachancea thermotolerans CBS 6340 KLTH0G07370p XP_002555358.1 598519 D 559295 CDS KLTH0G07392g 255718157 8293629 complement(599733..600476) 1 NC_013083.1 highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway converts 3-phosphoglycerate to 2- phosphoglycerate; KLTH0G07392p 600476 8293629 KLTH0G07392g Lachancea thermotolerans CBS 6340 KLTH0G07392p XP_002555359.1 599733 R 559295 CDS KLTH0G07414g 255718159 8293630 complement(601376..602332) 1 NC_013083.1 similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Hypothetical ORF; KLTH0G07414p 602332 8293630 KLTH0G07414g Lachancea thermotolerans CBS 6340 KLTH0G07414p XP_002555360.1 601376 R 559295 CDS KLTH0G07436g 255718161 8293631 603006..603884 1 NC_013083.1 highly similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase involved in ergosterol biosynthesis; KLTH0G07436p 603884 8293631 KLTH0G07436g Lachancea thermotolerans CBS 6340 KLTH0G07436p XP_002555361.1 603006 D 559295 CDS KLTH0G07458g 255718163 8293632 complement(603959..605119) 1 NC_013083.1 similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme involved in intron turnover required for efficient Ty1 transposition; KLTH0G07458p 605119 8293632 KLTH0G07458g Lachancea thermotolerans CBS 6340 KLTH0G07458p XP_002555362.1 603959 R 559295 CDS KLTH0G07480g 255718165 8293633 complement(605253..607166) 1 NC_013083.1 highly similar to uniprot|Q00711 Saccharomyces cerevisiae YKL148C SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone; KLTH0G07480p 607166 8293633 KLTH0G07480g Lachancea thermotolerans CBS 6340 KLTH0G07480p XP_002555363.1 605253 R 559295 CDS KLTH0G07502g 255718167 8293634 608628..610433 1 NC_013083.1 similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters; KLTH0G07502p 610433 8293634 KLTH0G07502g Lachancea thermotolerans CBS 6340 KLTH0G07502p XP_002555364.1 608628 D 559295 CDS KLTH0G07524g 255718169 8293635 join(610689..610802,611037..612260) 1 NC_013083.1 highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for optimal CDC20 transcription interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p; KLTH0G07524p 612260 8293635 KLTH0G07524g Lachancea thermotolerans CBS 6340 KLTH0G07524p XP_002555365.1 610689 D 559295 CDS KLTH0G07546g 255718171 8293636 complement(612418..613044) 1 NC_013083.1 highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25; KLTH0G07546p 613044 8293636 KLTH0G07546g Lachancea thermotolerans CBS 6340 KLTH0G07546p XP_002555366.1 612418 R 559295 CDS KLTH0G07568g 255718173 8293637 613460..614911 1 NC_013083.1 similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Protein required for growth at low temperature; KLTH0G07568p 614911 8293637 KLTH0G07568g Lachancea thermotolerans CBS 6340 KLTH0G07568p XP_002555367.1 613460 D 559295 CDS KLTH0G07590g 255718175 8293638 615156..615812 1 NC_013083.1 similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W; KLTH0G07590p 615812 8293638 KLTH0G07590g Lachancea thermotolerans CBS 6340 KLTH0G07590p XP_002555368.1 615156 D 559295 CDS KLTH0G07612g 255718177 8293639 complement(615951..617963) 1 NC_013083.1 similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C Protein required for cell viability; KLTH0G07612p 617963 8293639 KLTH0G07612g Lachancea thermotolerans CBS 6340 KLTH0G07612p XP_002555369.1 615951 R 559295 CDS KLTH0G07634g 255718179 8293640 complement(618184..619878) 1 NC_013083.1 highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0G07634p 619878 8293640 KLTH0G07634g Lachancea thermotolerans CBS 6340 KLTH0G07634p XP_002555370.1 618184 R 559295 CDS KLTH0G07678g 255718181 8293642 620405..622822 1 NC_013083.1 similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Required for Vacuolar Protein Sorting Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p.; KLTH0G07678p 622822 8293642 KLTH0G07678g Lachancea thermotolerans CBS 6340 KLTH0G07678p XP_002555371.1 620405 D 559295 CDS KLTH0G07700g 255718183 8293643 complement(622904..623503) 1 NC_013083.1 highly similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex which delays the onset of anaphase in cells with defects in mitotic spindle assembly forms a complex with Mad1p; KLTH0G07700p 623503 8293643 KLTH0G07700g Lachancea thermotolerans CBS 6340 KLTH0G07700p XP_002555372.1 622904 R 559295 CDS KLTH0G07744g 255718185 8293644 complement(624767..625741) 1 NC_013083.1 similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C; KLTH0G07744p 625741 8293644 KLTH0G07744g Lachancea thermotolerans CBS 6340 KLTH0G07744p XP_002555373.1 624767 R 559295 CDS KLTH0G07766g 255718187 8293645 complement(626094..628388) 1 NC_013083.1 highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; KLTH0G07766p 628388 8293645 KLTH0G07766g Lachancea thermotolerans CBS 6340 KLTH0G07766p XP_002555374.1 626094 R 559295 CDS KLTH0G07788g 255718189 8293646 628748..629386 1 NC_013083.1 similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C Hypothetical ORF; KLTH0G07788p 629386 8293646 KLTH0G07788g Lachancea thermotolerans CBS 6340 KLTH0G07788p XP_002555375.1 628748 D 559295 CDS KLTH0G07810g 255718191 8293647 complement(629597..631633) 1 NC_013083.1 highly similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p; KLTH0G07810p 631633 8293647 KLTH0G07810g Lachancea thermotolerans CBS 6340 KLTH0G07810p XP_002555376.1 629597 R 559295 CDS KLTH0G07832g 255718193 8293648 632433..633185 1 NC_013083.1 similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p; KLTH0G07832p 633185 8293648 KLTH0G07832g Lachancea thermotolerans CBS 6340 KLTH0G07832p XP_002555377.1 632433 D 559295 CDS KLTH0G07854g 255718195 8293649 complement(633221..634486) 1 NC_013083.1 similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin; KLTH0G07854p 634486 8293649 KLTH0G07854g Lachancea thermotolerans CBS 6340 KLTH0G07854p XP_002555378.1 633221 R 559295 CDS KLTH0G07876g 255718197 8293650 complement(635270..636652) 1 NC_013083.1 similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2); KLTH0G07876p 636652 8293650 KLTH0G07876g Lachancea thermotolerans CBS 6340 KLTH0G07876p XP_002555379.1 635270 R 559295 CDS KLTH0G07898g 255718199 8293651 636890..639490 1 NC_013083.1 similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p; KLTH0G07898p 639490 8293651 KLTH0G07898g Lachancea thermotolerans CBS 6340 KLTH0G07898p XP_002555380.1 636890 D 559295 CDS KLTH0G07920g 255718201 8293652 640089..641063 1 NC_013083.1 similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; KLTH0G07920p 641063 8293652 KLTH0G07920g Lachancea thermotolerans CBS 6340 KLTH0G07920p XP_002555381.1 640089 D 559295 CDS KLTH0G07942g 255718203 8293653 complement(641317..642480) 1 NC_013083.1 similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; KLTH0G07942p 642480 8293653 KLTH0G07942g Lachancea thermotolerans CBS 6340 KLTH0G07942p XP_002555382.1 641317 R 559295 CDS KLTH0G07964g 255718205 8293654 643559..646180 1 NC_013083.1 weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit involved in protein import/export and in export of RNAs possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC potential Cdc28p substrate; KLTH0G07964p 646180 8293654 KLTH0G07964g Lachancea thermotolerans CBS 6340 KLTH0G07964p XP_002555383.1 643559 D 559295 CDS KLTH0G07986g 255718207 8293655 complement(646652..648361) 1 NC_013083.1 weakly similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N- linked and O-linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family; KLTH0G07986p 648361 8293655 KLTH0G07986g Lachancea thermotolerans CBS 6340 KLTH0G07986p XP_002555384.1 646652 R 559295 CDS KLTH0G08008g 255718209 8293656 648554..648991 1 NC_013083.1 weakly similar to uniprot|Q12274 Saccharomyces cerevisiae YOR097C Hypothetical protein; KLTH0G08008p 648991 8293656 KLTH0G08008g Lachancea thermotolerans CBS 6340 KLTH0G08008p XP_002555385.1 648554 D 559295 CDS KLTH0G08030g 255718211 8293657 complement(join(649179..649607,649769..649909)) 1 NC_013083.1 highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W; KLTH0G08030p 649909 8293657 KLTH0G08030g Lachancea thermotolerans CBS 6340 KLTH0G08030p XP_002555386.1 649179 R 559295 CDS KLTH0G08052g 255718213 8293658 650856..651683 1 NC_013083.1 highly similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol- isomerase; KLTH0G08052p 651683 8293658 KLTH0G08052g Lachancea thermotolerans CBS 6340 KLTH0G08052p XP_002555387.1 650856 D 559295 CDS KLTH0G08074g 255718215 8293659 complement(651983..652537) 1 NC_013083.1 highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP- ribosylation factor GTPase of the Ras superfamily involved in development of polarity; KLTH0G08074p 652537 8293659 KLTH0G08074g Lachancea thermotolerans CBS 6340 KLTH0G08074p XP_002555388.1 651983 R 559295 CDS KLTH0G08096g 255718217 8293660 653942..658783 1 NC_013083.1 similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF; KLTH0G08096p 658783 8293660 KLTH0G08096g Lachancea thermotolerans CBS 6340 KLTH0G08096p XP_002555389.1 653942 D 559295 CDS KLTH0G08118g 255718219 8293661 659150..660802 1 NC_013083.1 similar to uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non-essential protein of unknown function; KLTH0G08118p 660802 8293661 KLTH0G08118g Lachancea thermotolerans CBS 6340 KLTH0G08118p XP_002555390.1 659150 D 559295 CDS KLTH0G08140g 255718221 8293662 661164..662909 1 NC_013083.1 similar to uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein- protein interactions in large-scale studies suggests a possible role in actin filament organization; KLTH0G08140p 662909 8293662 KLTH0G08140g Lachancea thermotolerans CBS 6340 KLTH0G08140p XP_002555391.1 661164 D 559295 CDS KLTH0G08162g 255718223 8293663 complement(663061..664086) 1 NC_013083.1 similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF; KLTH0G08162p 664086 8293663 KLTH0G08162g Lachancea thermotolerans CBS 6340 KLTH0G08162p XP_002555392.1 663061 R 559295 CDS KLTH0G08184g 255718225 8293664 664281..665942 1 NC_013083.1 similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown; KLTH0G08184p 665942 8293664 KLTH0G08184g Lachancea thermotolerans CBS 6340 KLTH0G08184p XP_002555393.1 664281 D 559295 CDS KLTH0G08206g 255718227 8293665 666127..666765 1 NC_013083.1 highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association; KLTH0G08206p 666765 8293665 KLTH0G08206g Lachancea thermotolerans CBS 6340 KLTH0G08206p XP_002555394.1 666127 D 559295 CDS KLTH0G08228g 255718229 8293666 complement(666947..668986) 1 NC_013083.1 similar to uniprot|Q12324 Saccharomyces cerevisiae YOR087W YVC1; KLTH0G08228p 668986 8293666 KLTH0G08228g Lachancea thermotolerans CBS 6340 KLTH0G08228p XP_002555395.1 666947 R 559295 CDS KLTH0G08250g 255718231 8293667 672012..675770 1 NC_013083.1 some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; KLTH0G08250p 675770 8293667 KLTH0G08250g Lachancea thermotolerans CBS 6340 KLTH0G08250p XP_002555396.1 672012 D 559295 CDS KLTH0G08294g 255718233 8293669 678358..678921 1 NC_013083.1 highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly; KLTH0G08294p 678921 8293669 KLTH0G08294g Lachancea thermotolerans CBS 6340 KLTH0G08294p XP_002555397.1 678358 D 559295 CDS KLTH0G08338g 255718235 8293671 679454..683764 1 NC_013083.1 similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis; KLTH0G08338p 683764 8293671 KLTH0G08338g Lachancea thermotolerans CBS 6340 KLTH0G08338p XP_002555398.1 679454 D 559295 CDS KLTH0G08360g 255718237 8293672 684153..687683 1 NC_013083.1 similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact; KLTH0G08360p 687683 8293672 KLTH0G08360g Lachancea thermotolerans CBS 6340 KLTH0G08360p XP_002555399.1 684153 D 559295 CDS KLTH0G08382g 255718239 8293673 687894..688187 1 NC_013083.1 similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF; KLTH0G08382p 688187 8293673 KLTH0G08382g Lachancea thermotolerans CBS 6340 KLTH0G08382p XP_002555400.1 687894 D 559295 CDS KLTH0G08404g 255718241 8293674 complement(688210..689253) 1 NC_013083.1 weakly similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins; KLTH0G08404p 689253 8293674 KLTH0G08404g Lachancea thermotolerans CBS 6340 KLTH0G08404p XP_002555401.1 688210 R 559295 CDS KLTH0G08426g 255718243 8293675 690275..692689 1 NC_013083.1 similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease; KLTH0G08426p 692689 8293675 KLTH0G08426g Lachancea thermotolerans CBS 6340 KLTH0G08426p XP_002555402.1 690275 D 559295 CDS KLTH0G08470g 255718245 8293677 694234..695820 1 NC_013083.1 highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0G08470p 695820 8293677 KLTH0G08470g Lachancea thermotolerans CBS 6340 KLTH0G08470p XP_002555403.1 694234 D 559295 CDS KLTH0G08492g 255718247 8293678 complement(695936..697150) 1 NC_013083.1 similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p; KLTH0G08492p 697150 8293678 KLTH0G08492g Lachancea thermotolerans CBS 6340 KLTH0G08492p XP_002555404.1 695936 R 559295 CDS KLTH0G08514g 255718249 8293679 697857..700331 1 NC_013083.1 similar to uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate; KLTH0G08514p 700331 8293679 KLTH0G08514g Lachancea thermotolerans CBS 6340 KLTH0G08514p XP_002555405.1 697857 D 559295 CDS KLTH0G08536g 255718251 8293680 complement(700491..702065) 1 NC_013083.1 conserved hypothetical protein; KLTH0G08536p 702065 8293680 KLTH0G08536g Lachancea thermotolerans CBS 6340 KLTH0G08536p XP_002555406.1 700491 R 559295 CDS KLTH0G08580g 255718253 8293682 703446..704993 1 NC_013083.1 similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 - binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains; KLTH0G08580p 704993 8293682 KLTH0G08580g Lachancea thermotolerans CBS 6340 KLTH0G08580p XP_002555407.1 703446 D 559295 CDS KLTH0G08602g 255718255 8293683 complement(705083..705814) 1 NC_013083.1 similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage; KLTH0G08602p 705814 8293683 KLTH0G08602g Lachancea thermotolerans CBS 6340 KLTH0G08602p XP_002555408.1 705083 R 559295 CDS KLTH0G08624g 255718257 8293684 705919..708639 1 NC_013083.1 similar to uniprot|P14242 Saccharomyces cerevisiae YNL082W; KLTH0G08624p 708639 8293684 KLTH0G08624g Lachancea thermotolerans CBS 6340 KLTH0G08624p XP_002555409.1 705919 D 559295 CDS KLTH0G08646g 255718259 8293685 complement(708704..709153) 1 NC_013083.1 highly similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2; KLTH0G08646p 709153 8293685 KLTH0G08646g Lachancea thermotolerans CBS 6340 KLTH0G08646p XP_002555410.1 708704 R 559295 CDS KLTH0G08668g 255718261 8293686 complement(709393..710451) 1 NC_013083.1 similar to uniprot|P53938 Saccharomyces cerevisiae YNL080C; KLTH0G08668p 710451 8293686 KLTH0G08668g Lachancea thermotolerans CBS 6340 KLTH0G08668p XP_002555411.1 709393 R 559295 CDS KLTH0G08690g 255718263 8293687 complement(711026..711937) 1 NC_013083.1 highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1 4- benzoquinone methyltransferase involved in ubiquinone (Coenzyme Q) biosynthesis located in mitochondria; KLTH0G08690p 711937 8293687 KLTH0G08690g Lachancea thermotolerans CBS 6340 KLTH0G08690p XP_002555412.1 711026 R 559295 CDS KLTH0G08734g 255718265 8293689 complement(join(713923..714390,714494..714511)) 1 NC_013083.1 similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C TPM2 Tropomyosin isoform 2 actin- binding protein that stabilizes actin filaments required with Tpm1 the main tropomyosin for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles; KLTH0G08734p 714511 8293689 KLTH0G08734g Lachancea thermotolerans CBS 6340 KLTH0G08734p XP_002555413.1 713923 R 559295 CDS KLTH0G08756g 255718267 8293690 complement(715507..716895) 1 NC_013083.1 similar to uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family overexpression interferes with propagation of the [Psi ] prion; KLTH0G08756p 716895 8293690 KLTH0G08756g Lachancea thermotolerans CBS 6340 KLTH0G08756p XP_002555414.1 715507 R 559295 CDS KLTH0G08778g 255718269 8293691 717652..720354 1 NC_013083.1 similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C RBF108 Hypothetical ORF; KLTH0G08778p 720354 8293691 KLTH0G08778g Lachancea thermotolerans CBS 6340 KLTH0G08778p XP_002555415.1 717652 D 559295 CDS KLTH0G08800g 255718271 8293692 complement(720613..721986) 1 NC_013083.1 weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase physically interacts with septins possibly involved in a mitotic signaling network; KLTH0G08800p 721986 8293692 KLTH0G08800g Lachancea thermotolerans CBS 6340 KLTH0G08800p XP_002555416.1 720613 R 559295 CDS KLTH0G08822g 255718273 8293693 723401..725035 1 NC_013083.1 weakly similar to uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function major constituent of the mitochondrial outer membrane located on the outer (cytosolic) face of the outer membrane; KLTH0G08822p 725035 8293693 KLTH0G08822g Lachancea thermotolerans CBS 6340 KLTH0G08822p XP_002555417.1 723401 D 559295 CDS KLTH0G08844g 255718275 8293694 725516..727264 1 NC_013083.1 weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling; KLTH0G08844p 727264 8293694 KLTH0G08844g Lachancea thermotolerans CBS 6340 KLTH0G08844p XP_002555418.1 725516 D 559295 CDS KLTH0G08866g 255718277 8293695 727640..728491 1 NC_013083.1 highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome which is required for pre-18S rRNA processing interacts with Mpp10p member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs; KLTH0G08866p 728491 8293695 KLTH0G08866g Lachancea thermotolerans CBS 6340 KLTH0G08866p XP_002555419.1 727640 D 559295 CDS KLTH0G08888g 255718279 8293696 complement(728865..730604) 1 NC_013083.1 some similarities with uniprot|P40463 Saccharomyces cerevisiae YIL135C VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation; KLTH0G08888p 730604 8293696 KLTH0G08888g Lachancea thermotolerans CBS 6340 KLTH0G08888p XP_002555420.1 728865 R 559295 CDS KLTH0G08954g 255718281 8294193 731432..733006 1 NC_013083.1 similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria; KLTH0G08954p 733006 8294193 KLTH0G08954g Lachancea thermotolerans CBS 6340 KLTH0G08954p XP_002555421.1 731432 D 559295 CDS KLTH0G08976g 255718283 8293699 733113..734141 1 NC_013083.1 similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit removes RNA primers during Okazaki fragment synthesis cooperates with Rad27p nuclease; KLTH0G08976p 734141 8293699 KLTH0G08976g Lachancea thermotolerans CBS 6340 KLTH0G08976p XP_002555422.1 733113 D 559295 CDS KLTH0G08998g 255718285 8293700 734671..736086 1 NC_013083.1 similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; KLTH0G08998p 736086 8293700 KLTH0G08998g Lachancea thermotolerans CBS 6340 KLTH0G08998p XP_002555423.1 734671 D 559295 CDS KLTH0G09020g 255718287 8293701 736937..737866 1 NC_013083.1 similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria where it is synthesized from riboflavin to the cytosol; KLTH0G09020p 737866 8293701 KLTH0G09020g Lachancea thermotolerans CBS 6340 KLTH0G09020p XP_002555424.1 736937 D 559295 CDS KLTH0G09042g 255718289 8293702 complement(join(738010..738578,738814..738847)) 1 NC_013083.1 highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p and to YNL069C uniprot|P26785 Saccharomyces cerevisiae YNL069C RPL16B N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p; KLTH0G09042p 738847 8293702 KLTH0G09042g Lachancea thermotolerans CBS 6340 KLTH0G09042p XP_002555425.1 738010 R 559295 CDS KLTH0G09064g 255718291 8293703 complement(739377..740039) 1 NC_013083.1 weakly similar to uniprot|P40465 Saccharomyces cerevisiae YIL132C CSM2 Protein required for accurate chromosome segregation during meiosis; KLTH0G09064p 740039 8293703 KLTH0G09064g Lachancea thermotolerans CBS 6340 KLTH0G09064p XP_002555426.1 739377 R 559295 CDS KLTH0G09086g 255718293 8293704 complement(join(741018..743258,743495..743542)) 1 NC_013083.1 similar to uniprot|P41813 Saccharomyces cerevisiae YNL068C FKH2 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth also involved in chromatin silencing at HML and HMR potential Cdc28p substrate; KLTH0G09086p 743542 8293704 KLTH0G09086g Lachancea thermotolerans CBS 6340 KLTH0G09086p XP_002555427.1 741018 R 559295 CDS KLTH0G09108g 255718295 8293705 744062..746410 1 NC_013083.1 weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins; KLTH0G09108p 746410 8293705 KLTH0G09108g Lachancea thermotolerans CBS 6340 KLTH0G09108p XP_002555428.1 744062 D 559295 CDS KLTH0G09130g 255718297 8293706 complement(746572..754329) 1 NC_013083.1 similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Identified in a hunt for mutants that activate OCH1 transcription Transcriptional Activator of OCH1; KLTH0G09130p 754329 8293706 KLTH0G09130g Lachancea thermotolerans CBS 6340 KLTH0G09130p XP_002555429.1 746572 R 559295 CDS KLTH0G09152g 255718299 8293707 755459..758518 1 NC_013083.1 similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription; KLTH0G09152p 758518 8293707 KLTH0G09152g Lachancea thermotolerans CBS 6340 KLTH0G09152p XP_002555430.1 755459 D 559295 CDS KLTH0G09174g 255718301 8293708 complement(758602..759195) 1 NC_013083.1 similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C Hypothetical ORF; KLTH0G09174p 759195 8293708 KLTH0G09174g Lachancea thermotolerans CBS 6340 KLTH0G09174p XP_002555431.1 758602 R 559295 CDS KLTH0G09196g 255718303 8293709 759594..763520 1 NC_013083.1 similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 helicase related protein snf2 homolog; KLTH0G09196p 763520 8293709 KLTH0G09196g Lachancea thermotolerans CBS 6340 KLTH0G09196p XP_002555432.1 759594 D 559295 CDS KLTH0G09218g 255718305 8293710 763754..764329 1 NC_013083.1 highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins; KLTH0G09218p 764329 8293710 KLTH0G09218g Lachancea thermotolerans CBS 6340 KLTH0G09218p XP_002555433.1 763754 D 559295 CDS KLTH0G09240g 255718307 8293711 complement(764752..766188) 1 NC_013083.1 conserved hypothetical protein; KLTH0G09240p 766188 8293711 KLTH0G09240g Lachancea thermotolerans CBS 6340 KLTH0G09240p XP_002555434.1 764752 R 559295 CDS KLTH0G09262g 255718309 8293712 767500..770541 1 NC_013083.1 highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a key step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA; KLTH0G09262p 770541 8293712 KLTH0G09262g Lachancea thermotolerans CBS 6340 KLTH0G09262p XP_002555435.1 767500 D 559295 CDS KLTH0G09284g 255718311 8293713 771061..771927 1 NC_013083.1 similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER involved in phosphatidic acid biosynthesis and required for spore germination capable of metabolizing mammalian steroid hormones; KLTH0G09284p 771927 8293713 KLTH0G09284g Lachancea thermotolerans CBS 6340 KLTH0G09284p XP_002555436.1 771061 D 559295 CDS KLTH0G09306g 255718313 8293714 773328..774662 1 NC_013083.1 some similarities with uniprot|P40472 Saccharomyces cerevisiae YIL123W SIM1 (putative) invovled in control of DNA replication; KLTH0G09306p 774662 8293714 KLTH0G09306g Lachancea thermotolerans CBS 6340 KLTH0G09306p XP_002555437.1 773328 D 559295 CDS KLTH0G09350g 255718315 8293716 778062..779753 1 NC_013083.1 similar to uniprot|P40474 Saccharomyces cerevisiae YIL121W QDR2 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS- MDR); KLTH0G09350p 779753 8293716 KLTH0G09350g Lachancea thermotolerans CBS 6340 KLTH0G09350p XP_002555438.1 778062 D 559295 CDS KLTH0G09372g 255718317 8293717 780184..781839 1 NC_013083.1 similar to uniprot|P53943 Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane transporter of the major facilitator superfamily that confers resistance to short- chain monocarboxylic acids and quinidine; KLTH0G09372p 781839 8293717 KLTH0G09372g Lachancea thermotolerans CBS 6340 KLTH0G09372p XP_002555439.1 780184 D 559295 CDS KLTH0G09394g 255718319 8293718 complement(782211..783446) 1 NC_013083.1 highly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 yeast dnaJ homolog (nuclear envelope protein) heat shock protein; KLTH0G09394p 783446 8293718 KLTH0G09394g Lachancea thermotolerans CBS 6340 KLTH0G09394p XP_002555440.1 782211 R 559295 CDS KLTH0G09416g 255718321 8293719 784397..785278 1 NC_013083.1 similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1; KLTH0G09416p 785278 8293719 KLTH0G09416g Lachancea thermotolerans CBS 6340 KLTH0G09416p XP_002555441.1 784397 D 559295 CDS KLTH0G09438g 255718323 8293720 complement(785300..786763) 1 NC_013083.1 similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1- methyladenosine) methyltransferase with Gcd14p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression; KLTH0G09438p 786763 8293720 KLTH0G09438g Lachancea thermotolerans CBS 6340 KLTH0G09438p XP_002555442.1 785300 R 559295 CDS KLTH0G09460g 255718325 8293721 787197..789110 1 NC_013083.1 similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis localized to the nucleolus; KLTH0G09460p 789110 8293721 KLTH0G09460g Lachancea thermotolerans CBS 6340 KLTH0G09460p XP_002555443.1 787197 D 559295 CDS KLTH0G09482g 255718327 8293722 complement(789233..791470) 1 NC_013083.1 similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; KLTH0G09482p 791470 8293722 KLTH0G09482g Lachancea thermotolerans CBS 6340 KLTH0G09482p XP_002555444.1 789233 R 559295 CDS KLTH0G09504g 255718329 8293723 complement(792202..794076) 1 NC_013083.1 similar to uniprot|P39980 Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates transcription is induced during iron deprivation and diauxic shift potentially phosphorylated by Cdc28p; KLTH0G09504p 794076 8293723 KLTH0G09504g Lachancea thermotolerans CBS 6340 KLTH0G09504p XP_002555445.1 792202 R 559295 CDS KLTH0G09526g 255718331 8293724 complement(794931..800147) 1 NC_013083.1 similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; KLTH0G09526p 800147 8293724 KLTH0G09526g Lachancea thermotolerans CBS 6340 KLTH0G09526p XP_002555446.1 794931 R 559295 CDS KLTH0G09548g 255718333 8293725 802001..802696 1 NC_013083.1 highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p; KLTH0G09548p 802696 8293725 KLTH0G09548g Lachancea thermotolerans CBS 6340 KLTH0G09548p XP_002555447.1 802001 D 559295 CDS KLTH0G09570g 255718335 8293726 complement(802806..803702) 1 NC_013083.1 weakly similar to uniprot|P40476 Saccharomyces cerevisiae YIL117C PRM5 Pheromone-regulated protein predicted to have 1 transmembrane segment induced during cell integrity signaling; KLTH0G09570p 803702 8293726 KLTH0G09570g Lachancea thermotolerans CBS 6340 KLTH0G09570p XP_002555448.1 802806 R 559295 CDS KLTH0G09592g 255718337 8293727 803888..804397 1 NC_013083.1 similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive- strand RNA viruses in their natural hosts; KLTH0G09592p 804397 8293727 KLTH0G09592g Lachancea thermotolerans CBS 6340 KLTH0G09592p XP_002555449.1 803888 D 559295 CDS KLTH0G09614g 255718339 8293728 804939..806108 1 NC_013083.1 similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase catalyzes the seventh step in histidine biosynthesis responsive to general control of amino acid biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts; KLTH0G09614p 806108 8293728 KLTH0G09614g Lachancea thermotolerans CBS 6340 KLTH0G09614p XP_002555450.1 804939 D 559295 CDS KLTH0G09636g 255718341 8293729 complement(806164..810963) 1 NC_013083.1 weakly similar to uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side forms a subcomplex with Nup82p and Nsp1p required for mRNA export; KLTH0G09636p 810963 8293729 KLTH0G09636g Lachancea thermotolerans CBS 6340 KLTH0G09636p XP_002555451.1 806164 R 559295 CDS KLTH0G09658g 255718343 8293730 complement(811056..811901) 1 NC_013083.1 similar to uniprot|P04840 Saccharomyces cerevisiae YNL055C POR1 Mitochondrial porin (voltage- dependent anion channel) outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; KLTH0G09658p 811901 8293730 KLTH0G09658g Lachancea thermotolerans CBS 6340 KLTH0G09658p XP_002555452.1 811056 R 559295 CDS KLTH0G09680g 255718345 8293731 813511..815556 1 NC_013083.1 weakly similar to uniprot|P53950 Saccharomyces cerevisiae YNL054W VAC7 Integral vacuolar membrane protein may function to regulate Fab1p kinase activity; KLTH0G09680p 815556 8293731 KLTH0G09680g Lachancea thermotolerans CBS 6340 KLTH0G09680p XP_002555453.1 813511 D 559295 CDS KLTH0G09702g 255718347 8293732 816434..817804 1 NC_013083.1 similar to uniprot|P38590 Saccharomyces cerevisiae YNL053W MSG5 Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway regulates and is regulated by Slt2p also required for adaptive response to pheromone; KLTH0G09702p 817804 8293732 KLTH0G09702g Lachancea thermotolerans CBS 6340 KLTH0G09702p XP_002555454.1 816434 D 559295 CDS KLTH0G09724g 255718349 8293733 818249..821470 1 NC_013083.1 similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate; KLTH0G09724p 821470 8293733 KLTH0G09724g Lachancea thermotolerans CBS 6340 KLTH0G09724p XP_002555455.1 818249 D 559295 CDS KLTH0G09746g 255718351 8293734 join(821736,822068..822519) 1 NC_013083.1 highly similar to uniprot|P00424 Saccharomyces cerevisiae or to YIL111W uniprot|P00425 Saccharomyces cerevisiae YIL111W; KLTH0G09746p 822519 8293734 KLTH0G09746g Lachancea thermotolerans CBS 6340 KLTH0G09746p XP_002555456.1 821736 D 559295 CDS KLTH0G09768g 255718353 8293735 823484..824611 1 NC_013083.1 similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0G09768p 824611 8293735 KLTH0G09768g Lachancea thermotolerans CBS 6340 KLTH0G09768p XP_002555457.1 823484 D 559295 CDS KLTH0G09790g 255718355 8293736 824749..825912 1 NC_013083.1 similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0G09790p 825912 8293736 KLTH0G09790g Lachancea thermotolerans CBS 6340 KLTH0G09790p XP_002555458.1 824749 D 559295 CDS KLTH0G09812g 255718357 8293737 complement(join(825945..826638,826707..826723)) 1 NC_013083.1 similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C; KLTH0G09812p 826723 8293737 KLTH0G09812g Lachancea thermotolerans CBS 6340 KLTH0G09812p XP_002555459.1 825945 R 559295 CDS KLTH0G09834g 255718359 8293738 complement(827019..829712) 1 NC_013083.1 similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C SEC24 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport vesicle coat component; KLTH0G09834p 829712 8293738 KLTH0G09834g Lachancea thermotolerans CBS 6340 KLTH0G09834p XP_002555460.1 827019 R 559295 CDS KLTH0G09856g 255718361 8293739 830050..832122 1 NC_013083.1 similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Hypothetical ORF; KLTH0G09856p 832122 8293739 KLTH0G09856g Lachancea thermotolerans CBS 6340 KLTH0G09856p XP_002555461.1 830050 D 559295 CDS KLTH0G09878g 255718363 8293740 complement(832255..834468) 1 NC_013083.1 similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3- phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A; KLTH0G09878p 834468 8293740 KLTH0G09878g Lachancea thermotolerans CBS 6340 KLTH0G09878p XP_002555462.1 832255 R 559295 CDS KLTH0G09900g 255718365 8293741 join(835892..835911,836014..836809) 1 NC_013083.1 similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Mps One Binder (putative) transcriptional regulator involved in mitosis; KLTH0G09900p 836809 8293741 KLTH0G09900g Lachancea thermotolerans CBS 6340 KLTH0G09900p XP_002555463.1 835892 D 559295 CDS KLTH0G09922g 255718367 8293742 837086..838807 1 NC_013083.1 similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1 2-mannosyltransferase catalyzes addition of the terminal alpha 1 2-Man to the Man5GlcNAc2- PP-dolichol intermediate during asparagine- linked glycosylation in the ER; KLTH0G09922p 838807 8293742 KLTH0G09922g Lachancea thermotolerans CBS 6340 KLTH0G09922p XP_002555464.1 837086 D 559295 CDS KLTH0G09944g 255718369 8293743 complement(838994..840952) 1 NC_013083.1 similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C SLM1 Phosphoinositide PI4 5P(2) binding protein forms a complex with Slm2p acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress phosphorylated by the Tor2p-containing complex TORC2; KLTH0G09944p 840952 8293743 KLTH0G09944g Lachancea thermotolerans CBS 6340 KLTH0G09944p XP_002555465.1 838994 R 559295 CDS KLTH0G09966g 255718371 8293744 841108..841497 1 NC_013083.1 conserved hypothetical protein; KLTH0G09966p 841497 8293744 KLTH0G09966g Lachancea thermotolerans CBS 6340 KLTH0G09966p XP_002555466.1 841108 D 559295 CDS KLTH0G09988g 255718373 8293745 join(845176..845199,845326..845832) 1 NC_013083.1 similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Interacts with YPT proteins; KLTH0G09988p 845832 8293745 KLTH0G09988g Lachancea thermotolerans CBS 6340 KLTH0G09988p XP_002555467.1 845176 D 559295 CDS KLTH0G10010g 255718375 8293746 846079..847041 1 NC_013083.1 weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function potential Cdc28p substrate overproduction suppresses a pam1 slv3 double null mutation; KLTH0G10010p 847041 8293746 KLTH0G10010g Lachancea thermotolerans CBS 6340 KLTH0G10010p XP_002555468.1 846079 D 559295 CDS KLTH0G10032g 255718377 8293747 complement(847078..848544) 1 NC_013083.1 similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Essential nuclear protein required for accumulation of box H/ACA snoRNAs and for rRNA processing interacts with Naf1p; KLTH0G10032p 848544 8293747 KLTH0G10032g Lachancea thermotolerans CBS 6340 KLTH0G10032p XP_002555469.1 847078 R 559295 CDS KLTH0G10054g 255718379 8293748 848726..849997 1 NC_013083.1 highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p; KLTH0G10054p 849997 8293748 KLTH0G10054g Lachancea thermotolerans CBS 6340 KLTH0G10054p XP_002555470.1 848726 D 559295 CDS KLTH0G10076g 255718381 8293749 complement(850022..852463) 1 NC_013083.1 similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0G10076p 852463 8293749 KLTH0G10076g Lachancea thermotolerans CBS 6340 KLTH0G10076p XP_002555471.1 850022 R 559295 CDS KLTH0G10098g 255718383 8293750 complement(853505..855454) 1 NC_013083.1 weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes CYS3 and SMF2 expression is induced by stress or starvation during mitosis and late in meiosis member of the Swi4p/Mbp1p family potential Cdc28p substrate; KLTH0G10098p 855454 8293750 KLTH0G10098g Lachancea thermotolerans CBS 6340 KLTH0G10098p XP_002555472.1 853505 R 559295 CDS KLTH0G10120g 255718385 8293751 complement(857050..857694) 1 NC_013083.1 similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions involved in non-classical protein export pathway; KLTH0G10120p 857694 8293751 KLTH0G10120g Lachancea thermotolerans CBS 6340 KLTH0G10120p XP_002555473.1 857050 R 559295 CDS KLTH0G10142g 255718387 8293752 858744..860582 1 NC_013083.1 similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation induced during starvation of a/a diploids late in sporulation but dispensable for sporulation; KLTH0G10142p 860582 8293752 KLTH0G10142g Lachancea thermotolerans CBS 6340 KLTH0G10142p XP_002555474.1 858744 D 559295 CDS KLTH0G10164g 255718389 8293753 complement(860681..861178) 1 NC_013083.1 similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; KLTH0G10164p 861178 8293753 KLTH0G10164g Lachancea thermotolerans CBS 6340 KLTH0G10164p XP_002555475.1 860681 R 559295 CDS KLTH0G10186g 255718391 8293754 863151..864233 1 NC_013083.1 highly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; KLTH0G10186p 864233 8293754 KLTH0G10186g Lachancea thermotolerans CBS 6340 KLTH0G10186p XP_002555476.1 863151 D 559295 CDS KLTH0G10208g 255718393 8293755 864735..866234 1 NC_013083.1 similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains CTLH domain; KLTH0G10208p 866234 8293755 KLTH0G10208g Lachancea thermotolerans CBS 6340 KLTH0G10208p XP_002555477.1 864735 D 559295 CDS KLTH0G10230g 255718395 8293756 complement(866253..867242) 1 NC_013083.1 similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Hypothetical ORF; KLTH0G10230p 867242 8293756 KLTH0G10230g Lachancea thermotolerans CBS 6340 KLTH0G10230p XP_002555478.1 866253 R 559295 CDS KLTH0G10252g 255718397 8293757 complement(867465..867953) 1 NC_013083.1 similar to uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N- acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-H protein; KLTH0G10252p 867953 8293757 KLTH0G10252g Lachancea thermotolerans CBS 6340 KLTH0G10252p XP_002555479.1 867465 R 559295 CDS KLTH0G10274g 255718399 8293758 complement(868108..869787) 1 NC_013083.1 similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB) which is involved in transcription of genes encoding tRNAs 5S rRNA U6 snRNA and other small RNAs; KLTH0G10274p 869787 8293758 KLTH0G10274g Lachancea thermotolerans CBS 6340 KLTH0G10274p XP_002555480.1 868108 R 559295 CDS KLTH0G10296g 255718401 8293759 complement(869990..871270) 1 NC_013083.1 similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Hypothetical ORF; KLTH0G10296p 871270 8293759 KLTH0G10296g Lachancea thermotolerans CBS 6340 KLTH0G10296p XP_002555481.1 869990 R 559295 CDS KLTH0G10318g 255718403 8293760 872129..874501 1 NC_013083.1 similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W PRK1 Protein serine/threonine kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p- Sla1p-End3p protein complex; KLTH0G10318p 874501 8293760 KLTH0G10318g Lachancea thermotolerans CBS 6340 KLTH0G10318p XP_002555482.1 872129 D 559295 CDS KLTH0G10340g 255718405 8293761 complement(874566..876692) 1 NC_013083.1 highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer deletion increases histone H2B H3 and H4 acetylation; KLTH0G10340p 876692 8293761 KLTH0G10340g Lachancea thermotolerans CBS 6340 KLTH0G10340p XP_002555483.1 874566 R 559295 CDS KLTH0G10362g 255718407 8293762 876756..878345 1 NC_013083.1 highly similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C; KLTH0G10362p 878345 8293762 KLTH0G10362g Lachancea thermotolerans CBS 6340 KLTH0G10362p XP_002555484.1 876756 D 559295 CDS KLTH0G10384g 255718409 8293763 complement(878375..879478) 1 NC_013083.1 highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate; KLTH0G10384p 879478 8293763 KLTH0G10384g Lachancea thermotolerans CBS 6340 KLTH0G10384p XP_002555485.1 878375 R 559295 CDS KLTH0G10406g 255718411 8293764 880042..882933 1 NC_013083.1 similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C; KLTH0G10406p 882933 8293764 KLTH0G10406g Lachancea thermotolerans CBS 6340 KLTH0G10406p XP_002555486.1 880042 D 559295 CDS KLTH0G10428g 255718413 8293765 883191..883946 1 NC_013083.1 similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0G10428p 883946 8293765 KLTH0G10428g Lachancea thermotolerans CBS 6340 KLTH0G10428p XP_002555487.1 883191 D 559295 CDS KLTH0G10450g 255718415 8293766 complement(884037..884822) 1 NC_013083.1 similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit; KLTH0G10450p 884822 8293766 KLTH0G10450g Lachancea thermotolerans CBS 6340 KLTH0G10450p XP_002555488.1 884037 R 559295 CDS KLTH0G10472g 255718417 8293767 885262..885480 1 NC_013083.1 highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A Identified by gene-trapping microarray-based expression analysis and genome-wide homology searching; KLTH0G10472p 885480 8293767 KLTH0G10472g Lachancea thermotolerans CBS 6340 KLTH0G10472p XP_002555489.1 885262 D 559295 CDS KLTH0G10494g 255718419 8293768 complement(885735..887978) 1 NC_013083.1 similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C Protein required for cell viability; KLTH0G10494p 887978 8293768 KLTH0G10494g Lachancea thermotolerans CBS 6340 KLTH0G10494p XP_002555490.1 885735 R 559295 CDS KLTH0G10516g 255718421 8293769 889468..890892 1 NC_013083.1 similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains mutations cause defects in cortical ER morphology in both the mother and daughter cells; KLTH0G10516p 890892 8293769 KLTH0G10516g Lachancea thermotolerans CBS 6340 KLTH0G10516p XP_002555491.1 889468 D 559295 CDS KLTH0G10560g 255718423 8294191 892671..893570 1 NC_013083.1 highly similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation; KLTH0G10560p 893570 8294191 KLTH0G10560g Lachancea thermotolerans CBS 6340 KLTH0G10560p XP_002555492.1 892671 D 559295 CDS KLTH0G10582g 255718425 8293771 893699..895000 1 NC_013083.1 weakly similar to uniprot|P28496 Saccharomyces cerevisiae LAC1 and to YHL003C uniprot|P38703 Saccharomyces cerevisiae LAG1; Ceramide synthase components, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine; KLTH0G10582p 895000 8293771 KLTH0G10582g Lachancea thermotolerans CBS 6340 KLTH0G10582p XP_002555493.1 893699 D 559295 CDS KLTH0G10604g 255718427 8293772 complement(895162..896568) 1 NC_013083.1 similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7; KLTH0G10604p 896568 8293772 KLTH0G10604g Lachancea thermotolerans CBS 6340 KLTH0G10604p XP_002555494.1 895162 R 559295 CDS KLTH0G10626g 255718429 8293773 896733..897644 1 NC_013083.1 similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis localized to the cytoplasm; KLTH0G10626p 897644 8293773 KLTH0G10626g Lachancea thermotolerans CBS 6340 KLTH0G10626p XP_002555495.1 896733 D 559295 CDS KLTH0G10648g 255718431 8293774 complement(897703..898131) 1 NC_013083.1 similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C Hypothetical ORF; KLTH0G10648p 898131 8293774 KLTH0G10648g Lachancea thermotolerans CBS 6340 KLTH0G10648p XP_002555496.1 897703 R 559295 CDS KLTH0G10670g 255718433 8293775 complement(898316..898726) 1 NC_013083.1 highly similar to uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 and highly similar to uniprot|P02303 Saccharomyces cerevisiae YBR010W HHT1; KLTH0G10670p 898726 8293775 KLTH0G10670g Lachancea thermotolerans CBS 6340 KLTH0G10670p XP_002555497.1 898316 R 559295 CDS KLTH0G10692g 255718435 8293776 899311..899622 1 NC_013083.1 highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; KLTH0G10692p 899622 8293776 KLTH0G10692g Lachancea thermotolerans CBS 6340 KLTH0G10692p XP_002555498.1 899311 D 559295 CDS KLTH0G10714g 255718437 8293777 complement(899864..901414) 1 NC_013083.1 similar to uniprot|P40504 Saccharomyces cerevisiae YIL085C KTR7 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family; KLTH0G10714p 901414 8293777 KLTH0G10714g Lachancea thermotolerans CBS 6340 KLTH0G10714p XP_002555499.1 899864 R 559295 CDS KLTH0G10736g 255718439 8293778 complement(902899..904605) 1 NC_013083.1 similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma- aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane; KLTH0G10736p 904605 8293778 KLTH0G10736g Lachancea thermotolerans CBS 6340 KLTH0G10736p XP_002555500.1 902899 R 559295 CDS KLTH0G10758g 255718441 8293779 complement(905696..906700) 1 NC_013083.1 similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C; KLTH0G10758p 906700 8293779 KLTH0G10758g Lachancea thermotolerans CBS 6340 KLTH0G10758p XP_002555501.1 905696 R 559295 CDS KLTH0G10780g 255718443 8293780 906878..908110 1 NC_013083.1 similar to uniprot|Q04235 Saccharomyces cerevisiae YML005W TRM12 Putative tRNA methyltransferase has a role in tRNA modification S-adenosylmethionine- dependent methyltransferase of the seven beta-strand family; KLTH0G10780p 908110 8293780 KLTH0G10780g Lachancea thermotolerans CBS 6340 KLTH0G10780p XP_002555502.1 906878 D 559295 CDS KLTH0G10802g 255718445 8293781 908386..909966 1 NC_013083.1 some similarities with uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; KLTH0G10802p 909966 8293781 KLTH0G10802g Lachancea thermotolerans CBS 6340 KLTH0G10802p XP_002555503.1 908386 D 559295 CDS KLTH0G10824g 255718447 8293782 910133..911620 1 NC_013083.1 similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria; KLTH0G10824p 911620 8293782 KLTH0G10824g Lachancea thermotolerans CBS 6340 KLTH0G10824p XP_002555504.1 910133 D 559295 CDS KLTH0G10846g 255718449 8293783 complement(911687..912736) 1 NC_013083.1 highly similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C Homolog to human PPCS; KLTH0G10846p 912736 8293783 KLTH0G10846g Lachancea thermotolerans CBS 6340 KLTH0G10846p XP_002555505.1 911687 R 559295 CDS KLTH0G10868g 255718451 8293784 913243..915762 1 NC_013083.1 similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K /H antiporter; KLTH0G10868p 915762 8293784 KLTH0G10868g Lachancea thermotolerans CBS 6340 KLTH0G10868p XP_002555506.1 913243 D 559295 CDS KLTH0G10912g 255718453 8293786 917604..918914 1 NC_013083.1 some similarities with uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly(A) RNA-binding protein abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs not reported to associate with polyribosomes; KLTH0G10912p 918914 8293786 KLTH0G10912g Lachancea thermotolerans CBS 6340 KLTH0G10912p XP_002555507.1 917604 D 559295 CDS KLTH0G10934g 255718455 8293787 919304..921580 1 NC_013083.1 similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions irrespective of their size capable of cleaving polyubiquitin chains; KLTH0G10934p 921580 8293787 KLTH0G10934g Lachancea thermotolerans CBS 6340 KLTH0G10934p XP_002555508.1 919304 D 559295 CDS KLTH0G10956g 255718457 8293788 complement(921704..922135) 1 NC_013083.1 some similarities with uniprot|Q07541 Saccharomyces cerevisiae YDL121C Hypothetical ORF; KLTH0G10956p 922135 8293788 KLTH0G10956g Lachancea thermotolerans CBS 6340 KLTH0G10956p XP_002555509.1 921704 R 559295 CDS KLTH0G10978g 255718459 8293789 922281..922793 1 NC_013083.1 similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Yeast Frataxin Homologue mitochondrial protein that regulates mitochondrial iron accumulation; KLTH0G10978p 922793 8293789 KLTH0G10978g Lachancea thermotolerans CBS 6340 KLTH0G10978p XP_002555510.1 922281 D 559295 CDS KLTH0G11000g 255718461 8293790 923620..926868 1 NC_013083.1 similar to uniprot|P22855 Saccharomyces cerevisiae YGL156W AMS1 vacuolar alpha mannosidase; KLTH0G11000p 926868 8293790 KLTH0G11000g Lachancea thermotolerans CBS 6340 KLTH0G11000p XP_002555511.1 923620 D 559295 CDS KLTH0G11022g 255718463 8293791 926990..928120 1 NC_013083.1 similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis; KLTH0G11022p 928120 8293791 KLTH0G11022g Lachancea thermotolerans CBS 6340 KLTH0G11022p XP_002555512.1 926990 D 559295 CDS KLTH0G11044g 255718465 8293792 complement(928161..929057) 1 NC_013083.1 similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C Hypothetical ORF; KLTH0G11044p 929057 8293792 KLTH0G11044g Lachancea thermotolerans CBS 6340 KLTH0G11044p XP_002555513.1 928161 R 559295 CDS KLTH0G11066g 255718467 8293793 complement(929174..930136) 1 NC_013083.1 similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine; KLTH0G11066p 930136 8293793 KLTH0G11066g Lachancea thermotolerans CBS 6340 KLTH0G11066p XP_002555514.1 929174 R 559295 CDS KLTH0G11088g 255718469 8293794 930082..931080 1 NC_013083.1 similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p; KLTH0G11088p 931080 8293794 KLTH0G11088g Lachancea thermotolerans CBS 6340 KLTH0G11088p XP_002555515.1 930082 D 559295 CDS KLTH0G11110g 255718471 8293795 931287..934514 1 NC_013083.1 similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription; KLTH0G11110p 934514 8293795 KLTH0G11110g Lachancea thermotolerans CBS 6340 KLTH0G11110p XP_002555516.1 931287 D 559295 CDS KLTH0G11132g 255718473 8293796 complement(934626..938645) 1 NC_013083.1 similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C; KLTH0G11132p 938645 8293796 KLTH0G11132g Lachancea thermotolerans CBS 6340 KLTH0G11132p XP_002555517.1 934626 R 559295 CDS KLTH0G11154g 255718475 8293797 complement(940157..941875) 1 NC_013083.1 conserved hypothetical protein; KLTH0G11154p 941875 8293797 KLTH0G11154g Lachancea thermotolerans CBS 6340 KLTH0G11154p XP_002555518.1 940157 R 559295 CDS KLTH0G11176g 255718477 8293798 942213..942788 1 NC_013083.1 conserved hypothetical protein; KLTH0G11176p 942788 8293798 KLTH0G11176g Lachancea thermotolerans CBS 6340 KLTH0G11176p XP_002555519.1 942213 D 559295 CDS KLTH0G11198g 255718479 8293799 944286..946334 1 NC_013083.1 highly similar to uniprot|P52910 Saccharomyces cerevisiae YLR153C ACS2 Acetyl-coA synthetase isoform required for growth on glucose expressed under anaerobic conditions; KLTH0G11198p 946334 8293799 KLTH0G11198g Lachancea thermotolerans CBS 6340 KLTH0G11198p XP_002555520.1 944286 D 559295 CDS KLTH0G11220g 255718481 8293800 947396..949255 1 NC_013083.1 some similarities with uniprot|P54072 Saccharomyces cerevisiae YLR152C Hypothetical ORF; KLTH0G11220p 949255 8293800 KLTH0G11220g Lachancea thermotolerans CBS 6340 KLTH0G11220p XP_002555521.1 947396 D 559295 CDS KLTH0G11242g 255718483 8293801 949387..950352 1 NC_013083.1 similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; KLTH0G11242p 950352 8293801 KLTH0G11242g Lachancea thermotolerans CBS 6340 KLTH0G11242p XP_002555522.1 949387 D 559295 CDS KLTH0G11264g 255718485 8293802 complement(join(950524..951297,951661..951666)) 1 NC_013083.1 similar to uniprot|P39015 Saccharomyces cerevisiae YLR150W STM1 Protein that binds quadruplex nucleic acids; KLTH0G11264p 951666 8293802 KLTH0G11264g Lachancea thermotolerans CBS 6340 KLTH0G11264p XP_002555523.1 950524 R 559295 CDS KLTH0G11286g 255718487 8293803 952541..953929 1 NC_013083.1 some similarities with uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3; KLTH0G11286p 953929 8293803 KLTH0G11286g Lachancea thermotolerans CBS 6340 KLTH0G11286p XP_002555524.1 952541 D 559295 CDS KLTH0G11308g 255718489 8293804 954331..956385 1 NC_013083.1 similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Hypothetical ORF; KLTH0G11308p 956385 8293804 KLTH0G11308g Lachancea thermotolerans CBS 6340 KLTH0G11308p XP_002555525.1 954331 D 559295 CDS KLTH0G11330g 255718491 8293805 complement(956495..958000) 1 NC_013083.1 similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle; KLTH0G11330p 958000 8293805 KLTH0G11330g Lachancea thermotolerans CBS 6340 KLTH0G11330p XP_002555526.1 956495 R 559295 CDS KLTH0G11352g 255718493 8293806 complement(958147..958743) 1 NC_013083.1 similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification; KLTH0G11352p 958743 8293806 KLTH0G11352g Lachancea thermotolerans CBS 6340 KLTH0G11352p XP_002555527.1 958147 R 559295 CDS KLTH0G11374g 255718495 8293807 complement(958910..961720) 1 NC_013083.1 similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins required for vacuolar biogenesis forms complex with Pep5p that mediates protein transport to the vacuole; KLTH0G11374p 961720 8293807 KLTH0G11374g Lachancea thermotolerans CBS 6340 KLTH0G11374p XP_002555528.1 958910 R 559295 CDS KLTH0G11396g 255718497 8293808 961756..962064 1 NC_013083.1 similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein; KLTH0G11396p 962064 8293808 KLTH0G11396g Lachancea thermotolerans CBS 6340 KLTH0G11396p XP_002555529.1 961756 D 559295 CDS KLTH0G11418g 255718499 8293809 962267..964960 1 NC_013083.1 similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis; KLTH0G11418p 964960 8293809 KLTH0G11418g Lachancea thermotolerans CBS 6340 KLTH0G11418p XP_002555530.1 962267 D 559295 CDS KLTH0G11440g 255718501 8293810 complement(964978..965271) 1 NC_013083.1 conserved hypothetical protein; KLTH0G11440p 965271 8293810 KLTH0G11440g Lachancea thermotolerans CBS 6340 KLTH0G11440p XP_002555531.1 964978 R 559295 CDS KLTH0G11462g 255718503 8293811 complement(965544..966875) 1 NC_013083.1 similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7- methylguanosine modification of tRNA; KLTH0G11462p 966875 8293811 KLTH0G11462g Lachancea thermotolerans CBS 6340 KLTH0G11462p XP_002555532.1 965544 R 559295 CDS KLTH0G11484g 255718505 8293812 967263..968144 1 NC_013083.1 similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine Synthase; KLTH0G11484p 968144 8293812 KLTH0G11484g Lachancea thermotolerans CBS 6340 KLTH0G11484p XP_002555533.1 967263 D 559295 CDS KLTH0G11506g 255718507 8293813 complement(968173..968775) 1 NC_013083.1 similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Protein required for cell viability component of RNase MRP which is involved in RNA processing in mitochondria; KLTH0G11506p 968775 8293813 KLTH0G11506g Lachancea thermotolerans CBS 6340 KLTH0G11506p XP_002555534.1 968173 R 559295 CDS KLTH0G11528g 255718509 8293814 969152..971461 1 NC_013083.1 similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1 3- endoglucanase expression is induced during sporulation may have a role in cortical actin cytoskeleton assembly; KLTH0G11528p 971461 8293814 KLTH0G11528g Lachancea thermotolerans CBS 6340 KLTH0G11528p XP_002555535.1 969152 D 559295 CDS KLTH0G11550g 255718511 8293815 join(971803..971833,971902..973976) 1 NC_013083.1 similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p; KLTH0G11550p 973976 8293815 KLTH0G11550g Lachancea thermotolerans CBS 6340 KLTH0G11550p XP_002555536.1 971803 D 559295 CDS KLTH0G11572g 255718513 8293816 complement(974033..974980) 1 NC_013083.1 conserved hypothetical protein; KLTH0G11572p 974980 8293816 KLTH0G11572g Lachancea thermotolerans CBS 6340 KLTH0G11572p XP_002555537.1 974033 R 559295 CDS KLTH0G11594g 255718515 8293817 complement(975378..977432) 1 NC_013083.1 similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Hypothetical ORF; KLTH0G11594p 977432 8293817 KLTH0G11594g Lachancea thermotolerans CBS 6340 KLTH0G11594p XP_002555538.1 975378 R 559295 CDS KLTH0G11616g 255718517 8293818 complement(977655..979091) 1 NC_013083.1 similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 proline oxidase; KLTH0G11616p 979091 8293818 KLTH0G11616g Lachancea thermotolerans CBS 6340 KLTH0G11616p XP_002555539.1 977655 R 559295 CDS KLTH0G11638g 255718519 8293819 complement(979562..981067) 1 NC_013083.1 weakly similar to uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Transcription factor member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p involved in transcription of rDNA by RNA polymerase I; KLTH0G11638p 981067 8293819 KLTH0G11638g Lachancea thermotolerans CBS 6340 KLTH0G11638p XP_002555540.1 979562 R 559295 CDS KLTH0G11660g 255718521 8293820 981214..983310 1 NC_013083.1 similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV coordinates expression of mitochondrially-encoded genes may facilitate delivery of mRNA to membrane-bound translation machinery; KLTH0G11660p 983310 8293820 KLTH0G11660g Lachancea thermotolerans CBS 6340 KLTH0G11660p XP_002555541.1 981214 D 559295 CDS KLTH0G11682g 255718523 8293821 984811..985374 1 NC_013083.1 weakly similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex found in the nucleus and cytoplasm contains an SH3 domain that binds Pbs2p; KLTH0G11682p 985374 8293821 KLTH0G11682g Lachancea thermotolerans CBS 6340 KLTH0G11682p XP_002555542.1 984811 D 559295 CDS KLTH0G11704g 255718525 8293822 complement(985593..986729) 1 NC_013083.1 similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W interacts with PP2C; KLTH0G11704p 986729 8293822 KLTH0G11704g Lachancea thermotolerans CBS 6340 KLTH0G11704p XP_002555543.1 985593 R 559295 CDS KLTH0G11726g 255718527 8293823 complement(986837..989311) 1 NC_013083.1 similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; KLTH0G11726p 989311 8293823 KLTH0G11726g Lachancea thermotolerans CBS 6340 KLTH0G11726p XP_002555544.1 986837 R 559295 CDS KLTH0G11748g 255718529 8293824 complement(join(989841..992789,992918..992941)) 1 NC_013083.1 similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W; KLTH0G11748p 992941 8293824 KLTH0G11748g Lachancea thermotolerans CBS 6340 KLTH0G11748p XP_002555545.1 989841 R 559295 CDS KLTH0G11770g 255718531 8293825 complement(993342..997166) 1 NC_013083.1 similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus; KLTH0G11770p 997166 8293825 KLTH0G11770g Lachancea thermotolerans CBS 6340 KLTH0G11770p XP_002555546.1 993342 R 559295 CDS KLTH0G11792g 255718533 8293826 complement(997347..998351) 1 NC_013083.1 similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W Hypothetical ORF; KLTH0G11792p 998351 8293826 KLTH0G11792g Lachancea thermotolerans CBS 6340 KLTH0G11792p XP_002555547.1 997347 R 559295 CDS KLTH0G11814g 255718535 8293827 complement(998449..999546) 1 NC_013083.1 highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis; KLTH0G11814p 999546 8293827 KLTH0G11814g Lachancea thermotolerans CBS 6340 KLTH0G11814p XP_002555548.1 998449 R 559295 CDS KLTH0G11836g 255718537 8293828 complement(999939..1000163) 1 NC_013083.1 conserved hypothetical protein; KLTH0G11836p 1000163 8293828 KLTH0G11836g Lachancea thermotolerans CBS 6340 KLTH0G11836p XP_002555549.1 999939 R 559295 CDS KLTH0G11880g 255718539 8293830 1001789..1002277 1 NC_013083.1 highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A; KLTH0G11880p 1002277 8293830 KLTH0G11880g Lachancea thermotolerans CBS 6340 KLTH0G11880p XP_002555550.1 1001789 D 559295 CDS KLTH0G11902g 255718541 8293831 1002588..1003787 1 NC_013083.1 similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p clathrin adaptor complex AP-1 and clathrin; KLTH0G11902p 1003787 8293831 KLTH0G11902g Lachancea thermotolerans CBS 6340 KLTH0G11902p XP_002555551.1 1002588 D 559295 CDS KLTH0G11924g 255718543 8293832 complement(1003887..1004639) 1 NC_013083.1 similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 RWD domain containing protein of unknown function; KLTH0G11924p 1004639 8293832 KLTH0G11924g Lachancea thermotolerans CBS 6340 KLTH0G11924p XP_002555552.1 1003887 R 559295 CDS KLTH0G11968g 255718545 8293834 complement(1005828..1007309) 1 NC_013083.1 some similarities with uniprot|P40890 Saccharomyces cerevisiae YJL222W; KLTH0G11968p 1007309 8293834 KLTH0G11968g Lachancea thermotolerans CBS 6340 KLTH0G11968p XP_002555553.1 1005828 R 559295 CDS KLTH0G11990g 255718547 8293835 complement(1008468..1010303) 1 NC_013083.1 some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments; KLTH0G11990p 1010303 8293835 KLTH0G11990g Lachancea thermotolerans CBS 6340 KLTH0G11990p XP_002555554.1 1008468 R 559295 CDS KLTH0G12034g 255718549 8293837 complement(1011773..1012615) 1 NC_013083.1 some similarities with uniprot|P40890 Saccharomyces cerevisiae YJL222W; KLTH0G12034p 1012615 8293837 KLTH0G12034g Lachancea thermotolerans CBS 6340 KLTH0G12034p XP_002555555.1 1011773 R 559295 CDS KLTH0G12056g 255718551 8293838 complement(1012940..1014760) 1 NC_013083.1 some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments; KLTH0G12056p 1014760 8293838 KLTH0G12056g Lachancea thermotolerans CBS 6340 KLTH0G12056p XP_002555556.1 1012940 R 559295 CDS KLTH0G12078g 255718553 8293839 complement(1015395..1016090) 1 NC_013083.1 some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments; KLTH0G12078p 1016090 8293839 KLTH0G12078g Lachancea thermotolerans CBS 6340 KLTH0G12078p XP_002555557.1 1015395 R 559295 CDS KLTH0G12100g 255718555 8293840 1016735..1017574 1 NC_013083.1 some similarities with uniprot|P47976 Saccharomyces cerevisiae YDR151C; KLTH0G12100p 1017574 8293840 KLTH0G12100g Lachancea thermotolerans CBS 6340 KLTH0G12100p XP_002555558.1 1016735 D 559295 CDS KLTH0G12122g 255718557 8293841 complement(join(1017758..1019860,1019904..1020035)) 1 NC_013083.1 similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C; KLTH0G12122p 1020035 8293841 KLTH0G12122g Lachancea thermotolerans CBS 6340 KLTH0G12122p XP_002555559.1 1017758 R 559295 CDS KLTH0G12144g 255718559 8293842 complement(1020201..1030949) 1 NC_013083.1 weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration localizes to the mother cell cortex and the bud tip may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex; KLTH0G12144p 1030949 8293842 KLTH0G12144g Lachancea thermotolerans CBS 6340 KLTH0G12144p XP_002555560.1 1020201 R 559295 CDS KLTH0G12166g 255718561 8293843 complement(1031601..1033577) 1 NC_013083.1 weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Subunit of a complex with Slx1p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p; KLTH0G12166p 1033577 8293843 KLTH0G12166g Lachancea thermotolerans CBS 6340 KLTH0G12166p XP_002555561.1 1031601 R 559295 CDS KLTH0G12188g 255718563 8293844 1035434..1036759 1 NC_013083.1 similar to uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha- ketoglutarate to succinyl-CoA; KLTH0G12188p 1036759 8293844 KLTH0G12188g Lachancea thermotolerans CBS 6340 KLTH0G12188p XP_002555562.1 1035434 D 559295 CDS KLTH0G12210g 255718565 8293845 complement(1036985..1038592) 1 NC_013083.1 similar to uniprot|P20485 Saccharomyces cerevisiae YLR133W CKI1 choline kinase; KLTH0G12210p 1038592 8293845 KLTH0G12210g Lachancea thermotolerans CBS 6340 KLTH0G12210p XP_002555563.1 1036985 R 559295 CDS KLTH0G12232g 255718567 8293846 1038848..1039756 1 NC_013083.1 weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132c; KLTH0G12232p 1039756 8293846 KLTH0G12232g Lachancea thermotolerans CBS 6340 KLTH0G12232p XP_002555564.1 1038848 D 559295 CDS KLTH0G12254g 255718569 8293847 1040230..1042470 1 NC_013083.1 weakly similar to uniprot|P21192 Saccharomyces cerevisiae YLR131C ACE2 Transcription factor that activates expression of early G1-specific genes localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters localization is regulated by phosphorylation potential Cdc28p substrate; KLTH0G12254p 1042470 8293847 KLTH0G12254g Lachancea thermotolerans CBS 6340 KLTH0G12254p XP_002555565.1 1040230 D 559295 CDS KLTH0G12276g 255718571 8293848 complement(1042617..1045430) 1 NC_013083.1 highly similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein specifically associated with the U3 snoRNA part of the large ribonucleoprotein complex known as the small subunit (SSU) processome required for 18S rRNA biogenesis part of the active pre-rRNA processing complex; KLTH0G12276p 1045430 8293848 KLTH0G12276g Lachancea thermotolerans CBS 6340 KLTH0G12276p XP_002555566.1 1042617 R 559295 CDS KLTH0G12298g 255718573 8293849 complement(1045663..1047165) 1 NC_013083.1 similar to uniprot|Q03761 Saccharomyces cerevisiae YDR145W; KLTH0G12298p 1047165 8293849 KLTH0G12298g Lachancea thermotolerans CBS 6340 KLTH0G12298p XP_002555567.1 1045663 R 559295 CDS KLTH0G12320g 255718575 8293850 complement(join(1047486..1048247,1048313..1048315)) 1 NC_013083.1 similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Hypothetical ORF; KLTH0G12320p 1048315 8293850 KLTH0G12320g Lachancea thermotolerans CBS 6340 KLTH0G12320p XP_002555568.1 1047486 R 559295 CDS KLTH0G12342g 255718577 8293851 1048457..1050781 1 NC_013083.1 similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C; KLTH0G12342p 1050781 8293851 KLTH0G12342g Lachancea thermotolerans CBS 6340 KLTH0G12342p XP_002555569.1 1048457 D 559295 CDS KLTH0G12364g 255718579 8293852 1051261..1052034 1 NC_013083.1 similar to uniprot|Q12288 Saccharomyces cerevisiae YLR126C Hypothetical ORF; KLTH0G12364p 1052034 8293852 KLTH0G12364g Lachancea thermotolerans CBS 6340 KLTH0G12364p XP_002555570.1 1051261 D 559295 CDS KLTH0G12386g 255718581 8293853 1052977..1054719 1 NC_013083.1 similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466.; KLTH0G12386p 1054719 8293853 KLTH0G12386g Lachancea thermotolerans CBS 6340 KLTH0G12386p XP_002555571.1 1052977 D 559295 CDS KLTH0G12408g 255718583 8293854 1055265..1057076 1 NC_013083.1 weakly similar to uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing; KLTH0G12408p 1057076 8293854 KLTH0G12408g Lachancea thermotolerans CBS 6340 KLTH0G12408p XP_002555572.1 1055265 D 559295 CDS KLTH0G12430g 255718585 8293855 1057236..1058339 1 NC_013083.1 similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) Member of beta-transducin-related (WD-40) protein family; KLTH0G12430p 1058339 8293855 KLTH0G12430g Lachancea thermotolerans CBS 6340 KLTH0G12430p XP_002555573.1 1057236 D 559295 CDS KLTH0G12452g 255718587 8293856 complement(1058360..1058896) 1 NC_013083.1 weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W; KLTH0G12452p 1058896 8293856 KLTH0G12452g Lachancea thermotolerans CBS 6340 KLTH0G12452p XP_002555574.1 1058360 R 559295 CDS KLTH0G12474g 255718589 8293857 1059087..1059776 1 NC_013083.1 similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C; KLTH0G12474p 1059776 8293857 KLTH0G12474g Lachancea thermotolerans CBS 6340 KLTH0G12474p XP_002555575.1 1059087 D 559295 CDS KLTH0G12496g 255718591 8293858 1060028..1065058 1 NC_013083.1 similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1; KLTH0G12496p 1065058 8293858 KLTH0G12496g Lachancea thermotolerans CBS 6340 KLTH0G12496p XP_002555576.1 1060028 D 559295 CDS KLTH0G12518g 255718593 8293859 complement(1065049..1065711) 1 NC_013083.1 similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 Putative S-adenosylmethionine- dependent methyltransferase of the seven beta-strand family methylates release factor eRF1 (Sup45p) in vitro; KLTH0G12518p 1065711 8293859 KLTH0G12518g Lachancea thermotolerans CBS 6340 KLTH0G12518p XP_002555577.1 1065049 R 559295 CDS KLTH0G12540g 255718595 8293860 join(1065801..1065949,1066013..1066097) 1 NC_013083.1 similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8; KLTH0G12540p 1066097 8293860 KLTH0G12540g Lachancea thermotolerans CBS 6340 KLTH0G12540p XP_002555578.1 1065801 D 559295 CDS KLTH0G12562g 255718597 8293861 1066299..1068476 1 NC_013083.1 similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 SYnthetic lethal with cdcForty Crooked neck Like Factor an ortholog of the Drosophila crooked neck gene crn pre-mRNA splicing factor; KLTH0G12562p 1068476 8293861 KLTH0G12562g Lachancea thermotolerans CBS 6340 KLTH0G12562p XP_002555579.1 1066299 D 559295 CDS KLTH0G12584g 255718599 8293862 complement(1068526..1070130) 1 NC_013083.1 some similarities with uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex which defines the first step in the splicing pathway essential protein that interacts with Mud2p and Prp40p forming a bridge between the intron ends also involved in nuclear retention of pre-mRNA; KLTH0G12584p 1070130 8293862 KLTH0G12584g Lachancea thermotolerans CBS 6340 KLTH0G12584p XP_002555580.1 1068526 R 559295 CDS KLTH0G12606g 255718601 8293863 complement(1070300..1072750) 1 NC_013083.1 similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W; KLTH0G12606p 1072750 8293863 KLTH0G12606g Lachancea thermotolerans CBS 6340 KLTH0G12606p XP_002555581.1 1070300 R 559295 CDS KLTH0G12628g 255718603 8293864 complement(1073421..1075679) 1 NC_013083.1 some similarities with uniprot|P17629 Saccharomyces cerevisiae YDR138W; KLTH0G12628p 1075679 8293864 KLTH0G12628g Lachancea thermotolerans CBS 6340 KLTH0G12628p XP_002555582.1 1073421 R 559295 CDS KLTH0G12650g 255718605 8293865 1075871..1077790 1 NC_013083.1 similar to uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 PHO85 Requiring; KLTH0G12650p 1077790 8293865 KLTH0G12650g Lachancea thermotolerans CBS 6340 KLTH0G12650p XP_002555583.1 1075871 D 559295 CDS KLTH0G12672g 255718607 8293866 complement(1077868..1079685) 1 NC_013083.1 similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p; KLTH0G12672p 1079685 8293866 KLTH0G12672g Lachancea thermotolerans CBS 6340 KLTH0G12672p XP_002555584.1 1077868 R 559295 CDS KLTH0G12716g 255718609 8293868 1080818..1085320 1 NC_013083.1 highly similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C; KLTH0G12716p 1085320 8293868 KLTH0G12716g Lachancea thermotolerans CBS 6340 KLTH0G12716p XP_002555585.1 1080818 D 559295 CDS KLTH0G12738g 255718611 8293869 complement(1085500..1086804) 1 NC_013083.1 highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters localization regulated by Ptp2p and Ptp3p; KLTH0G12738p 1086804 8293869 KLTH0G12738g Lachancea thermotolerans CBS 6340 KLTH0G12738p XP_002555586.1 1085500 R 559295 CDS KLTH0G12760g 255718613 8293870 1088531..1088896 1 NC_013083.1 some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C CCW12 Cell wall protein mutants are defective in mating and agglutination expression is downregulated by alpha-factor; KLTH0G12760p 1088896 8293870 KLTH0G12760g Lachancea thermotolerans CBS 6340 KLTH0G12760p XP_002555587.1 1088531 D 559295 CDS KLTH0G12782g 255718615 8293871 1089138..1090442 1 NC_013083.1 weakly similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C Hypothetical ORF; KLTH0G12782p 1090442 8293871 KLTH0G12782g Lachancea thermotolerans CBS 6340 KLTH0G12782p XP_002555588.1 1089138 D 559295 CDS KLTH0G12826g 255718617 8294189 1090896..1092470 1 NC_013083.1 similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C Hypothetical ORF; KLTH0G12826p 1092470 8294189 KLTH0G12826g Lachancea thermotolerans CBS 6340 KLTH0G12826p XP_002555589.1 1090896 D 559295 CDS KLTH0G12848g 255718619 8293873 1092731..1093525 1 NC_013083.1 similar to uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Basic protein with putative coiled- coil regions that comprises a filament between spindle pole bodies self-assembles into filaments with a diameter of approximately 10 nm potential Cdc28p substrate; KLTH0G12848p 1093525 8293873 KLTH0G12848g Lachancea thermotolerans CBS 6340 KLTH0G12848p XP_002555590.1 1092731 D 559295 CDS KLTH0G12870g 255718621 8293874 complement(1093554..1094732) 1 NC_013083.1 similar to uniprot|Q7LI70 Saccharomyces cerevisiae YLR107W; KLTH0G12870p 1094732 8293874 KLTH0G12870g Lachancea thermotolerans CBS 6340 KLTH0G12870p XP_002555591.1 1093554 R 559295 CDS KLTH0G12892g 255718623 8293875 1095023..1109809 1 NC_013083.1 similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin) forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p) may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm; KLTH0G12892p 1109809 8293875 KLTH0G12892g Lachancea thermotolerans CBS 6340 KLTH0G12892p XP_002555592.1 1095023 D 559295 CDS KLTH0G12936g 255718625 8294194 1110501..1111556 1 NC_013083.1 similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C; KLTH0G12936p 1111556 8294194 KLTH0G12936g Lachancea thermotolerans CBS 6340 KLTH0G12936p XP_002555593.1 1110501 D 559295 CDS KLTH0G12958g 255718627 8293877 complement(1111611..1111994) 1 NC_013083.1 similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W Hypothetical ORF; KLTH0G12958p 1111994 8293877 KLTH0G12958g Lachancea thermotolerans CBS 6340 KLTH0G12958p XP_002555594.1 1111611 R 559295 CDS KLTH0G12980g 255718629 8293878 1112178..1114091 1 NC_013083.1 highly similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor; KLTH0G12980p 1114091 8293878 KLTH0G12980g Lachancea thermotolerans CBS 6340 KLTH0G12980p XP_002555595.1 1112178 D 559295 CDS KLTH0G13002g 255718631 8293879 1114318..1115028 1 NC_013083.1 weakly similar to uniprot|Q12107 Saccharomyces cerevisiae YLR102C APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0G13002p 1115028 8293879 KLTH0G13002g Lachancea thermotolerans CBS 6340 KLTH0G13002p XP_002555596.1 1114318 D 559295 CDS KLTH0G13024g 255718633 8293880 join(1115231..1115251,1115330..1117240) 1 NC_013083.1 highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; KLTH0G13024p 1117240 8293880 KLTH0G13024g Lachancea thermotolerans CBS 6340 KLTH0G13024p XP_002555597.1 1115231 D 559295 CDS KLTH0G13046g 255718635 8293881 complement(join(1117337..1118336,1118399..1118442)) 1 NC_013083.1 similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG273-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs; KLTH0G13046p 1118442 8293881 KLTH0G13046g Lachancea thermotolerans CBS 6340 KLTH0G13046p XP_002555598.1 1117337 R 559295 CDS KLTH0G13068g 255718637 8293882 complement(1118964..1122269) 1 NC_013083.1 similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W Hypothetical ORF; KLTH0G13068p 1122269 8293882 KLTH0G13068g Lachancea thermotolerans CBS 6340 KLTH0G13068p XP_002555599.1 1118964 R 559295 CDS KLTH0G13090g 255718639 8293883 complement(1124055..1128794) 1 NC_013083.1 highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein catalyzes steps 2 through 6 in the biosynthesis of chorismate which is a precursor to aromatic amino acids; KLTH0G13090p 1128794 8293883 KLTH0G13090g Lachancea thermotolerans CBS 6340 KLTH0G13090p XP_002555600.1 1124055 R 559295 CDS KLTH0G13112g 255718641 8293884 complement(1129318..1130367) 1 NC_013083.1 similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Spore Wall Formation; KLTH0G13112p 1130367 8293884 KLTH0G13112g Lachancea thermotolerans CBS 6340 KLTH0G13112p XP_002555601.1 1129318 R 559295 CDS KLTH0G13134g 255718643 8293885 1130586..1131059 1 NC_013083.1 conserved hypothetical protein; KLTH0G13134p 1131059 8293885 KLTH0G13134g Lachancea thermotolerans CBS 6340 KLTH0G13134p XP_002555602.1 1130586 D 559295 CDS KLTH0G13156g 255718645 8293886 complement(1131119..1131445) 1 NC_013083.1 some similarities with uniprot|Q3E798 YLR099W-A Saccharomyces cerevisiae; KLTH0G13156p 1131445 8293886 KLTH0G13156g Lachancea thermotolerans CBS 6340 KLTH0G13156p XP_002555603.1 1131119 R 559295 CDS KLTH0G13178g 255718647 8293887 1131579..1132826 1 NC_013083.1 similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C; KLTH0G13178p 1132826 8293887 KLTH0G13178g Lachancea thermotolerans CBS 6340 KLTH0G13178p XP_002555604.1 1131579 D 559295 CDS KLTH0G13200g 255718649 8293888 join(1133333..1133382,1133450..1135100) 1 NC_013083.1 highly similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2)[INTRON]; KLTH0G13200p 1135100 8293888 KLTH0G13200g Lachancea thermotolerans CBS 6340 KLTH0G13200p XP_002555605.1 1133333 D 559295 CDS KLTH0G13222g 255718651 8293889 complement(1135290..1136297) 1 NC_013083.1 weakly similar to uniprot|Q04608 Saccharomyces cerevisiae YDR124W Hypothetical ORF; KLTH0G13222p 1136297 8293889 KLTH0G13222g Lachancea thermotolerans CBS 6340 KLTH0G13222p XP_002555606.1 1135290 R 559295 CDS KLTH0G13244g 255718653 8293890 1136572..1137681 1 NC_013083.1 similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative nuclear ubiquitin ligase based on computational analysis of large-scale protein- protein interaction data; KLTH0G13244p 1137681 8293890 KLTH0G13244g Lachancea thermotolerans CBS 6340 KLTH0G13244p XP_002555607.1 1136572 D 559295 CDS KLTH0G13266g 255718655 8293891 1137951..1138844 1 NC_013083.1 weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs) required for derepression of phospholipid biosynthetic genes in response to inositol depletion; KLTH0G13266p 1138844 8293891 KLTH0G13266g Lachancea thermotolerans CBS 6340 KLTH0G13266p XP_002555608.1 1137951 D 559295 CDS KLTH0G13288g 255718657 8293892 complement(1139058..1142486) 1 NC_013083.1 similar to uniprot|P13186 Saccharomyces cerevisiae YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p and to YDR122W uniprot|P13185 Saccharomyces cerevisiae YDR122W KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p; KLTH0G13288p 1142486 8293892 KLTH0G13288g Lachancea thermotolerans CBS 6340 KLTH0G13288p XP_002555609.1 1139058 R 559295 CDS KLTH0G13310g 255718659 8293893 1143024..1145018 1 NC_013083.1 similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p; KLTH0G13310p 1145018 8293893 KLTH0G13310g Lachancea thermotolerans CBS 6340 KLTH0G13310p XP_002555610.1 1143024 D 559295 CDS KLTH0G13332g 255718661 8293894 1145732..1147204 1 NC_013083.1 some similarities with uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function; KLTH0G13332p 1147204 8293894 KLTH0G13332g Lachancea thermotolerans CBS 6340 KLTH0G13332p XP_002555611.1 1145732 D 559295 CDS KLTH0G13354g 255718663 8293895 1147582..1149090 1 NC_013083.1 some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins; KLTH0G13354p 1149090 8293895 KLTH0G13354g Lachancea thermotolerans CBS 6340 KLTH0G13354p XP_002555612.1 1147582 D 559295 CDS KLTH0G13376g 255718665 8293896 join(1149234..1149249,1149315..1149985) 1 NC_013083.1 similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion inhibits ATP- dependent Ca(2 ) transport activity of Pmc1p in the vacuolar membrane; KLTH0G13376p 1149985 8293896 KLTH0G13376g Lachancea thermotolerans CBS 6340 KLTH0G13376p XP_002555613.1 1149234 D 559295 CDS KLTH0G13398g 255718667 8293897 complement(1150007..1150603) 1 NC_013083.1 weakly similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex involved in both chromosomal DNA replication and in inheritance of telomeric silencing; KLTH0G13398p 1150603 8293897 KLTH0G13398g Lachancea thermotolerans CBS 6340 KLTH0G13398p XP_002555614.1 1150007 R 559295 CDS KLTH0G13420g 255718669 8293898 1151037..1152665 1 NC_013083.1 similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase localizes to both the nucleus and mitochondrion to produce the modified base N2 N2-dimethylguanosine in tRNAs in both compartments; KLTH0G13420p 1152665 8293898 KLTH0G13420g Lachancea thermotolerans CBS 6340 KLTH0G13420p XP_002555615.1 1151037 D 559295 CDS KLTH0G13442g 255718671 8293899 complement(1152840..1153064) 1 NC_013083.1 conserved hypothetical protein; KLTH0G13442p 1153064 8293899 KLTH0G13442g Lachancea thermotolerans CBS 6340 KLTH0G13442p XP_002555616.1 1152840 R 559295 CDS KLTH0G13464g 255718673 8293900 complement(1154304..1156085) 1 NC_013083.1 weakly similar to uniprot|Q04602 Saccharomyces cerevisiae YDR119W Uncharacterized transporter; KLTH0G13464p 1156085 8293900 KLTH0G13464g Lachancea thermotolerans CBS 6340 KLTH0G13464p XP_002555617.1 1154304 R 559295 CDS KLTH0G13486g 255718675 8293901 complement(1156678..1159386) 1 NC_013083.1 similar to uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 High affinity sulfate permease sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p which control the concentration of endogenous activated sulfate intermediates and uniprot|P38359 Saccharomyces cerevisiae YBR294W SUL1; KLTH0G13486p 1159386 8293901 KLTH0G13486g Lachancea thermotolerans CBS 6340 KLTH0G13486p XP_002555618.1 1156678 R 559295 CDS KLTH0G13508g 255718677 8293902 complement(1159671..1161608) 1 NC_013083.1 some similarities with uniprot|Q04601 Saccharomyces cerevisiae YDR118W APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); KLTH0G13508p 1161608 8293902 KLTH0G13508g Lachancea thermotolerans CBS 6340 KLTH0G13508p XP_002555619.1 1159671 R 559295 CDS KLTH0G13530g 255718679 8293903 1161702..1163426 1 NC_013083.1 similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C RBF64 Hypothetical ORF; KLTH0G13530p 1163426 8293903 KLTH0G13530g Lachancea thermotolerans CBS 6340 KLTH0G13530p XP_002555620.1 1161702 D 559295 CDS KLTH0G13552g 255718681 8293904 1163624..1164469 1 NC_013083.1 similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit; KLTH0G13552p 1164469 8293904 KLTH0G13552g Lachancea thermotolerans CBS 6340 KLTH0G13552p XP_002555621.1 1163624 D 559295 CDS KLTH0G13574g 255718683 8293905 complement(1164609..1164947) 1 NC_013083.1 some similarities with uniprot|Q04598 Saccharomyces cerevisiae YDR115W; KLTH0G13574p 1164947 8293905 KLTH0G13574g Lachancea thermotolerans CBS 6340 KLTH0G13574p XP_002555622.1 1164609 R 559295 CDS KLTH0G13596g 255718685 8293906 complement(1165293..1166096) 1 NC_013083.1 weakly similar to uniprot|Q12393 Saccharomyces cerevisiae YLR091W Hypothetical ORF; KLTH0G13596p 1166096 8293906 KLTH0G13596g Lachancea thermotolerans CBS 6340 KLTH0G13596p XP_002555623.1 1165293 R 559295 CDS KLTH0G13618g 255718687 8293907 1166359..1167267 1 NC_013083.1 weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1; KLTH0G13618p 1167267 8293907 KLTH0G13618g Lachancea thermotolerans CBS 6340 KLTH0G13618p XP_002555624.1 1166359 D 559295 CDS KLTH0G13640g 255718689 8293908 complement(1167336..1168580) 1 NC_013083.1 similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative homolog of E. coli DnaJ closely related to Ydj1p; KLTH0G13640p 1168580 8293908 KLTH0G13640g Lachancea thermotolerans CBS 6340 KLTH0G13640p XP_002555625.1 1167336 R 559295 CDS KLTH0G13662g 255718691 8293909 1169989..1171548 1 NC_013083.1 similar to uniprot|P52893 Saccharomyces cerevisiae YLR089C ALT1 putative alanine transaminase (glutamyc pyruvic transaminase); KLTH0G13662p 1171548 8293909 KLTH0G13662g Lachancea thermotolerans CBS 6340 KLTH0G13662p XP_002555626.1 1169989 D 559295 CDS KLTH0G13684g 255718693 8293910 complement(1171645..1173171) 1 NC_013083.1 weakly similar to uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities binds to the replication fork barrier site in the rDNA region related to retroviral integrases; KLTH0G13684p 1173171 8293910 KLTH0G13684g Lachancea thermotolerans CBS 6340 KLTH0G13684p XP_002555627.1 1171645 R 559295 CDS KLTH0G13706g 255718695 8293911 complement(1173326..1175080) 1 NC_013083.1 similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI:protein transamidase complex removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; KLTH0G13706p 1175080 8293911 KLTH0G13706g Lachancea thermotolerans CBS 6340 KLTH0G13706p XP_002555628.1 1173326 R 559295 CDS KLTH0G13728g 255718697 8293912 1175228..1184128 1 NC_013083.1 similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature; KLTH0G13728p 1184128 8293912 KLTH0G13728g Lachancea thermotolerans CBS 6340 KLTH0G13728p XP_002555629.1 1175228 D 559295 CDS KLTH0G13750g 255718699 8293913 complement(1184169..1188368) 1 NC_013083.1 similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex which reorganizes chromosomes during cell division forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA- binding activity and promotes knotting of circular DNA potential Cdc28p substrate; KLTH0G13750p 1188368 8293913 KLTH0G13750g Lachancea thermotolerans CBS 6340 KLTH0G13750p XP_002555630.1 1184169 R 559295 CDS KLTH0G13772g 255718701 8293914 1188875..1190137 1 NC_013083.1 similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; KLTH0G13772p 1190137 8293914 KLTH0G13772g Lachancea thermotolerans CBS 6340 KLTH0G13772p XP_002555631.1 1188875 D 559295 CDS KLTH0G13794g 255718703 8293915 1191104..1193281 1 NC_013083.1 similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF; KLTH0G13794p 1193281 8293915 KLTH0G13794g Lachancea thermotolerans CBS 6340 KLTH0G13794p XP_002555632.1 1191104 D 559295 CDS KLTH0G13816g 255718705 8293916 1194256..1196223 1 NC_013083.1 conserved hypothetical protein; KLTH0G13816p 1196223 8293916 KLTH0G13816g Lachancea thermotolerans CBS 6340 KLTH0G13816p XP_002555633.1 1194256 D 559295 CDS KLTH0G13838g 255718707 8293917 1197919..1201563 1 NC_013083.1 similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding localization requires Rax1p; KLTH0G13838p 1201563 8293917 KLTH0G13838g Lachancea thermotolerans CBS 6340 KLTH0G13838p XP_002555634.1 1197919 D 559295 CDS KLTH0G13860g 255718709 8293918 complement(1201656..1203782) 1 NC_013083.1 similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W GSG1 Subunit of TRAPP (transport protein particle) a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment protein has late meiotic role following DNA replication; KLTH0G13860p 1203782 8293918 KLTH0G13860g Lachancea thermotolerans CBS 6340 KLTH0G13860p XP_002555635.1 1201656 R 559295 CDS KLTH0G13882g 255718711 8293919 1204180..1206243 1 NC_013083.1 similar to uniprot|P32802 Saccharomyces cerevisiae YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions predicted to be a transmembrane protein; KLTH0G13882p 1206243 8293919 KLTH0G13882g Lachancea thermotolerans CBS 6340 KLTH0G13882p XP_002555636.1 1204180 D 559295 CDS KLTH0G13926g 255718713 8293921 1207234..1207491 1 NC_013083.1 similar to uniprot|Q3E784 Saccharomyces cerevisiae YER180C-A SLO1 SCOCO like ORF; KLTH0G13926p 1207491 8293921 KLTH0G13926g Lachancea thermotolerans CBS 6340 KLTH0G13926p XP_002555637.1 1207234 D 559295 CDS KLTH0G13948g 255718715 8293922 1207713..1208543 1 NC_013083.1 weakly similar to uniprot|P32645 Saccharomyces cerevisiae YER180C ISC10 Protein required for sporulation transcript is induced 7.5 hours after induction of meiosis expected to play significant role in the formation of reproductive cells; KLTH0G13948p 1208543 8293922 KLTH0G13948g Lachancea thermotolerans CBS 6340 KLTH0G13948p XP_002555638.1 1207713 D 559295 CDS KLTH0G13970g 255718717 8293923 complement(1208540..1209454) 1 NC_013083.1 weakly similar to uniprot|Q04549 Saccharomyces cerevisiae YDR106W; KLTH0G13970p 1209454 8293923 KLTH0G13970g Lachancea thermotolerans CBS 6340 KLTH0G13970p XP_002555639.1 1208540 R 559295 CDS KLTH0G13992g 255718719 8293924 1209585..1210997 1 NC_013083.1 similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Putative membrane protein conserved in mammals; KLTH0G13992p 1210997 8293924 KLTH0G13992g Lachancea thermotolerans CBS 6340 KLTH0G13992p XP_002555640.1 1209585 D 559295 CDS KLTH0G14014g 255718721 8293925 complement(join(1211052..1211924,1211999..1212127)) 1 NC_013083.1 highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes homolog of Rad51p and the bacterial RecA protein; KLTH0G14014p 1212127 8293925 KLTH0G14014g Lachancea thermotolerans CBS 6340 KLTH0G14014p XP_002555641.1 1211052 R 559295 CDS KLTH0G14036g 255718723 8293926 complement(1212527..1214311) 1 NC_013083.1 similar to uniprot|Q03862 Saccharomyces cerevisiae YDR101C ARX1 Protein associated with the ribosomal export complex; KLTH0G14036p 1214311 8293926 KLTH0G14036g Lachancea thermotolerans CBS 6340 KLTH0G14036p XP_002555642.1 1212527 R 559295 CDS KLTH0G14058g 255718725 8293927 1215951..1217192 1 NC_013083.1 highly similar to uniprot|P16387 Saccharomyces cerevisiae YER178W PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; KLTH0G14058p 1217192 8293927 KLTH0G14058g Lachancea thermotolerans CBS 6340 KLTH0G14058p XP_002555643.1 1215951 D 559295 CDS KLTH0G14080g 255718727 8293928 1217945..1220767 1 NC_013083.1 similar to uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Scaffold protein that in response to pheromone shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p Ste7p and Fus3p into a specific signaling complex active oligomeric form interacts with Ste4p-Ste18p complex; KLTH0G14080p 1220767 8293928 KLTH0G14080g Lachancea thermotolerans CBS 6340 KLTH0G14080p XP_002555644.1 1217945 D 559295 CDS KLTH0G14102g 255718729 8293929 complement(1220886..1224641) 1 NC_013083.1 similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis; KLTH0G14102p 1224641 8293929 KLTH0G14102g Lachancea thermotolerans CBS 6340 KLTH0G14102p XP_002555645.1 1220886 R 559295 CDS KLTH0G14124g 255718731 8293930 complement(1225114..1225533) 1 NC_013083.1 similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Tlg2-Vesicle Protein of 15 kDa integral membrane vesicle protein; KLTH0G14124p 1225533 8293930 KLTH0G14124g Lachancea thermotolerans CBS 6340 KLTH0G14124p XP_002555646.1 1225114 R 559295 CDS KLTH0G14146g 255718733 8293931 complement(1226975..1227736) 1 NC_013083.1 highly similar to uniprot|P34730 Saccharomyces cerevisiae YDR099W BMH2 14-3-3 protein minor isoform binds proteins and DNA involved in regulation of many processes including exocytosis and vesicle transport Ras/MAPK signaling during pseudohyphal development rapamycin- sensitive signaling and others; KLTH0G14146p 1227736 8293931 KLTH0G14146g Lachancea thermotolerans CBS 6340 KLTH0G14146p XP_002555647.1 1226975 R 559295 CDS KLTH0G14190g 255718735 8293933 complement(1229215..1232466) 1 NC_013083.1 similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination interacts with the translation termination factors localized to polysomes; KLTH0G14190p 1232466 8293933 KLTH0G14190g Lachancea thermotolerans CBS 6340 KLTH0G14190p XP_002555648.1 1229215 R 559295 CDS KLTH0G14212g 255718737 8293934 1232673..1233530 1 NC_013083.1 similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase; KLTH0G14212p 1233530 8293934 KLTH0G14212g Lachancea thermotolerans CBS 6340 KLTH0G14212p XP_002555649.1 1232673 D 559295 CDS KLTH0G14234g 255718739 8293935 1233911..1234633 1 NC_013083.1 similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide- radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage; KLTH0G14234p 1234633 8293935 KLTH0G14234g Lachancea thermotolerans CBS 6340 KLTH0G14234p XP_002555650.1 1233911 D 559295 CDS KLTH0G14256g 255718741 8293936 complement(1234736..1236652) 1 NC_013083.1 weakly similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein; KLTH0G14256p 1236652 8293936 KLTH0G14256g Lachancea thermotolerans CBS 6340 KLTH0G14256p XP_002555651.1 1234736 R 559295 CDS KLTH0G14278g 255718743 8293937 1236981..1243502 1 NC_013083.1 similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; KLTH0G14278p 1243502 8293937 KLTH0G14278g Lachancea thermotolerans CBS 6340 KLTH0G14278p XP_002555652.1 1236981 D 559295 CDS KLTH0G14300g 255718745 8293938 complement(1243568..1245916) 1 NC_013083.1 highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein; KLTH0G14300p 1245916 8293938 KLTH0G14300g Lachancea thermotolerans CBS 6340 KLTH0G14300p XP_002555653.1 1243568 R 559295 CDS KLTH0G14322g 255718747 8293939 complement(1246234..1246911) 1 NC_013083.1 similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background; KLTH0G14322p 1246911 8293939 KLTH0G14322g Lachancea thermotolerans CBS 6340 KLTH0G14322p XP_002555654.1 1246234 R 559295 CDS KLTH0G14344g 255718749 8293940 1248269..1250032 1 NC_013083.1 highly similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G; KLTH0G14344p 1250032 8293940 KLTH0G14344g Lachancea thermotolerans CBS 6340 KLTH0G14344p XP_002555655.1 1248269 D 559295 CDS KLTH0G14366g 255718751 8293941 join(1251249..1251278,1251389..1251808) 1 NC_013083.1 highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus; KLTH0G14366p 1251808 8293941 KLTH0G14366g Lachancea thermotolerans CBS 6340 KLTH0G14366p XP_002555656.1 1251249 D 559295 CDS KLTH0G14388g 255718753 8293942 1252357..1257063 1 NC_013083.1 similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport; KLTH0G14388p 1257063 8293942 KLTH0G14388g Lachancea thermotolerans CBS 6340 KLTH0G14388p XP_002555657.1 1252357 D 559295 CDS KLTH0G14410g 255718755 8293943 1257705..1259795 1 NC_013083.1 some similarities with uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations; KLTH0G14410p 1259795 8293943 KLTH0G14410g Lachancea thermotolerans CBS 6340 KLTH0G14410p XP_002555658.1 1257705 D 559295 CDS KLTH0G14432g 255718757 8293944 complement(1259927..1261486) 1 NC_013083.1 similar to uniprot|P21269 Saccharomyces cerevisiae YER168C CCA1 tRNA nucleotidyltransferase (tRNA CCA- pyrophosphorylase); KLTH0G14432p 1261486 8293944 KLTH0G14432g Lachancea thermotolerans CBS 6340 KLTH0G14432p XP_002555659.1 1259927 R 559295 CDS KLTH0G14454g 255718759 8293945 1263253..1265751 1 NC_013083.1 some similarities with uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; KLTH0G14454p 1265751 8293945 KLTH0G14454g Lachancea thermotolerans CBS 6340 KLTH0G14454p XP_002555660.1 1263253 D 559295 CDS KLTH0G14476g 255718761 8293946 complement(1265899..1269729) 1 NC_013083.1 similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p; KLTH0G14476p 1269729 8293946 KLTH0G14476g Lachancea thermotolerans CBS 6340 KLTH0G14476p XP_002555661.1 1265899 R 559295 CDS KLTH0G14498g 255718763 8293947 complement(1270093..1274403) 1 NC_013083.1 similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator; KLTH0G14498p 1274403 8293947 KLTH0G14498g Lachancea thermotolerans CBS 6340 KLTH0G14498p XP_002555662.1 1270093 R 559295 CDS KLTH0G14520g 255718765 8293948 1276585..1278411 1 NC_013083.1 highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis; KLTH0G14520p 1278411 8293948 KLTH0G14520g Lachancea thermotolerans CBS 6340 KLTH0G14520p XP_002555663.1 1276585 D 559295 CDS KLTH0G14542g 255718767 8293949 complement(1279215..1279922) 1 NC_013083.1 similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF; KLTH0G14542p 1279922 8293949 KLTH0G14542g Lachancea thermotolerans CBS 6340 KLTH0G14542p XP_002555664.1 1279215 R 559295 CDS KLTH0G14564g 255718769 8293950 1281787..1284363 1 NC_013083.1 similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) homolog of human XPC protein; KLTH0G14564p 1284363 8293950 KLTH0G14564g Lachancea thermotolerans CBS 6340 KLTH0G14564p XP_002555665.1 1281787 D 559295 CDS KLTH0G14586g 255718771 8293951 1284720..1285670 1 NC_013083.1 weakly similar to uniprot|P06843 Saccharomyces cerevisiae YER161c SPT2 multifunctional HMG-like chromatin protein; KLTH0G14586p 1285670 8293951 KLTH0G14586g Lachancea thermotolerans CBS 6340 KLTH0G14586p XP_002555666.1 1284720 D 559295 CDS KLTH0G14608g 255718773 8293952 complement(1285757..1288234) 1 NC_013083.1 similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Hypothetical ORF; KLTH0G14608p 1288234 8293952 KLTH0G14608g Lachancea thermotolerans CBS 6340 KLTH0G14608p XP_002555667.1 1285757 R 559295 CDS KLTH0G14630g 255718775 8293953 1289111..1290127 1 NC_013083.1 similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 Protein involved in 3' splice site choices acts in concert with Prp18p during the 2nd step of splicing; KLTH0G14630p 1290127 8293953 KLTH0G14630g Lachancea thermotolerans CBS 6340 KLTH0G14630p XP_002555668.1 1289111 D 559295 CDS KLTH0G14652g 255718777 8293954 1290815..1291672 1 NC_013083.1 similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing; KLTH0G14652p 1291672 8293954 KLTH0G14652g Lachancea thermotolerans CBS 6340 KLTH0G14652p XP_002555669.1 1290815 D 559295 CDS KLTH0G14674g 255718779 8293955 1291860..1292072 1 NC_013083.1 similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex; KLTH0G14674p 1292072 8293955 KLTH0G14674g Lachancea thermotolerans CBS 6340 KLTH0G14674p XP_002555670.1 1291860 D 559295 CDS KLTH0G14696g 255718781 8293956 1292523..1292843 1 NC_013083.1 similar to uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone- fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha; KLTH0G14696p 1292843 8293956 KLTH0G14696g Lachancea thermotolerans CBS 6340 KLTH0G14696p XP_002555671.1 1292523 D 559295 CDS KLTH0G14718g 255718783 8293957 1293895..1295502 1 NC_013083.1 conserved hypothetical protein; KLTH0G14718p 1295502 8293957 KLTH0G14718g Lachancea thermotolerans CBS 6340 KLTH0G14718p XP_002555672.1 1293895 D 559295 CDS KLTH0G14740g 255718785 8293958 1296005..1298011 1 NC_013083.1 some similarities with uniprot|P33304 Saccharomyces cerevisiae YDR085C; KLTH0G14740p 1298011 8293958 KLTH0G14740g Lachancea thermotolerans CBS 6340 KLTH0G14740p XP_002555673.1 1296005 D 559295 CDS KLTH0G14762g 255718787 8293959 1298851..1299438 1 NC_013083.1 similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0G14762p 1299438 8293959 KLTH0G14762g Lachancea thermotolerans CBS 6340 KLTH0G14762p XP_002555674.1 1298851 D 559295 CDS KLTH0G14784g 255718789 8293960 complement(1299536..1300789) 1 NC_013083.1 highly similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W; KLTH0G14784p 1300789 8293960 KLTH0G14784g Lachancea thermotolerans CBS 6340 KLTH0G14784p XP_002555675.1 1299536 R 559295 CDS KLTH0G14806g 255718791 8293961 1302699..1303040 1 NC_013083.1 similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0G14806p 1303040 8293961 KLTH0G14806g Lachancea thermotolerans CBS 6340 KLTH0G14806p XP_002555676.1 1302699 D 559295 CDS KLTH0G14828g 255718793 8293962 1303104..1303973 1 NC_013083.1 conserved hypothetical protein; KLTH0G14828p 1303973 8293962 KLTH0G14828g Lachancea thermotolerans CBS 6340 KLTH0G14828p XP_002555677.1 1303104 D 559295 CDS KLTH0G14850g 255718795 8293963 1304240..1304884 1 NC_013083.1 highly similar to uniprot|P32835 Saccharomyces cerevisiae YLR293C GSP1 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport regulated by Prp20p Rna1p Yrb1p Yrb2p Yrp4p Yrb30p Cse1p and Kap95p yeast Gsp2p homolog; KLTH0G14850p 1304884 8293963 KLTH0G14850g Lachancea thermotolerans CBS 6340 KLTH0G14850p XP_002555678.1 1304240 D 559295 CDS KLTH0G14872g 255718797 8293964 1305558..1306148 1 NC_013083.1 similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER; KLTH0G14872p 1306148 8293964 KLTH0G14872g Lachancea thermotolerans CBS 6340 KLTH0G14872p XP_002555679.1 1305558 D 559295 CDS KLTH0G14894g 255718799 8293965 1306454..1307545 1 NC_013083.1 highly similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression; KLTH0G14894p 1307545 8293965 KLTH0G14894g Lachancea thermotolerans CBS 6340 KLTH0G14894p XP_002555680.1 1306454 D 559295 CDS KLTH0G14916g 255718801 8293966 1307999..1308808 1 NC_013083.1 similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C Hypothetical ORF; KLTH0G14916p 1308808 8293966 KLTH0G14916g Lachancea thermotolerans CBS 6340 KLTH0G14916p XP_002555681.1 1307999 D 559295 CDS KLTH0G14938g 255718803 8293967 complement(1308877..1310799) 1 NC_013083.1 highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function; KLTH0G14938p 1310799 8293967 KLTH0G14938g Lachancea thermotolerans CBS 6340 KLTH0G14938p XP_002555682.1 1308877 R 559295 CDS KLTH0G14960g 255718805 8293968 1310947..1312200 1 NC_013083.1 similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein; KLTH0G14960p 1312200 8293968 KLTH0G14960g Lachancea thermotolerans CBS 6340 KLTH0G14960p XP_002555683.1 1310947 D 559295 CDS KLTH0G14982g 255718807 8293969 complement(1312553..1313737) 1 NC_013083.1 highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase; KLTH0G14982p 1313737 8293969 KLTH0G14982g Lachancea thermotolerans CBS 6340 KLTH0G14982p XP_002555684.1 1312553 R 559295 CDS KLTH0G15004g 255718809 8293970 join(1314627..1314629,1315011..1315196) 1 NC_013083.1 highly similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B and highly similar to uniprot|Q12087 Saccharomyces cerevisiae YLR287C-A RPS30A; KLTH0G15004p 1315196 8293970 KLTH0G15004g Lachancea thermotolerans CBS 6340 KLTH0G15004p XP_002555685.1 1314627 D 559295 CDS KLTH0G15026g 255718811 8293971 1315387..1316454 1 NC_013083.1 similar to uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF; KLTH0G15026p 1316454 8293971 KLTH0G15026g Lachancea thermotolerans CBS 6340 KLTH0G15026p XP_002555686.1 1315387 D 559295 CDS KLTH0G15048g 255718813 8293972 complement(1316543..1318507) 1 NC_013083.1 similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP); KLTH0G15048p 1318507 8293972 KLTH0G15048g Lachancea thermotolerans CBS 6340 KLTH0G15048p XP_002555687.1 1316543 R 559295 CDS KLTH0G15070g 255718815 8293973 1319937..1321739 1 NC_013083.1 similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p; KLTH0G15070p 1321739 8293973 KLTH0G15070g Lachancea thermotolerans CBS 6340 KLTH0G15070p XP_002555688.1 1319937 D 559295 CDS KLTH0G15092g 255718817 8293974 complement(1321863..1322663) 1 NC_013083.1 similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N- methyltransferase has a role in rDNA silencing and in lifespan determination; KLTH0G15092p 1322663 8293974 KLTH0G15092g Lachancea thermotolerans CBS 6340 KLTH0G15092p XP_002555689.1 1321863 R 559295 CDS KLTH0G15114g 255718819 8293975 1323693..1324529 1 NC_013083.1 similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl- CoA isomerase hexameric protein that converts 3-hexenoyl- CoA to trans-2-hexenoyl-CoA essential for the beta- oxidation of unsaturated fatty acids oleate-induced; KLTH0G15114p 1324529 8293975 KLTH0G15114g Lachancea thermotolerans CBS 6340 KLTH0G15114p XP_002555690.1 1323693 D 559295 CDS KLTH0G15136g 255718821 8293976 complement(1324606..1325439) 1 NC_013083.1 similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF; KLTH0G15136p 1325439 8293976 KLTH0G15136g Lachancea thermotolerans CBS 6340 KLTH0G15136p XP_002555691.1 1324606 R 559295 CDS KLTH0G15158g 255718823 8293977 1325781..1326248 1 NC_013083.1 similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF; KLTH0G15158p 1326248 8293977 KLTH0G15158g Lachancea thermotolerans CBS 6340 KLTH0G15158p XP_002555692.1 1325781 D 559295 CDS KLTH0G15180g 255718825 8293978 1326581..1329871 1 NC_013083.1 similar to uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate; KLTH0G15180p 1329871 8293978 KLTH0G15180g Lachancea thermotolerans CBS 6340 KLTH0G15180p XP_002555693.1 1326581 D 559295 CDS KLTH0G15202g 255718827 8293979 1330352..1332619 1 NC_013083.1 highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I); KLTH0G15202p 1332619 8293979 KLTH0G15202g Lachancea thermotolerans CBS 6340 KLTH0G15202p XP_002555694.1 1330352 D 559295 CDS KLTH0G15224g 255718829 8293980 1332767..1334557 1 NC_013083.1 highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit; KLTH0G15224p 1334557 8293980 KLTH0G15224g Lachancea thermotolerans CBS 6340 KLTH0G15224p XP_002555695.1 1332767 D 559295 CDS KLTH0G15246g 255718831 8293981 complement(join(1334670..1334991,1335059..1335063)) 1 NC_013083.1 highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 U1 snRNP protein of the Sm class; KLTH0G15246p 1335063 8293981 KLTH0G15246g Lachancea thermotolerans CBS 6340 KLTH0G15246p XP_002555696.1 1334670 R 559295 CDS KLTH0G15268g 255718833 8293982 complement(1335242..1337536) 1 NC_013083.1 highly similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W CDC46 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase; KLTH0G15268p 1337536 8293982 KLTH0G15268g Lachancea thermotolerans CBS 6340 KLTH0G15268p XP_002555697.1 1335242 R 559295 CDS KLTH0G15290g 255718835 8293983 1339162..1339458 1 NC_013083.1 no similarity; KLTH0G15290p 1339458 8293983 KLTH0G15290g Lachancea thermotolerans CBS 6340 KLTH0G15290p XP_002555698.1 1339162 D 559295 CDS KLTH0G15312g 255718837 8293984 1340924..1343206 1 NC_013083.1 weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis regulatory role also predicted for glucose repression and ion homeostasis potential Cdc28p substrate; KLTH0G15312p 1343206 8293984 KLTH0G15312g Lachancea thermotolerans CBS 6340 KLTH0G15312p XP_002555699.1 1340924 D 559295 CDS KLTH0G15334g 255718839 8293985 1343754..1345502 1 NC_013083.1 conserved hypothetical protein; KLTH0G15334p 1345502 8293985 KLTH0G15334g Lachancea thermotolerans CBS 6340 KLTH0G15334p XP_002555700.1 1343754 D 559295 CDS KLTH0G15378g 255718841 8293987 1346600..1350046 1 NC_013083.1 similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Protein required for accurate sister chromatid segregation; KLTH0G15378p 1350046 8293987 KLTH0G15378g Lachancea thermotolerans CBS 6340 KLTH0G15378p XP_002555701.1 1346600 D 559295 CDS KLTH0G15400g 255718843 8293988 complement(1350109..1351245) 1 NC_013083.1 highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase a mitochondrial inner membrane protein catalyzes the insertion of ferrous iron into protoporphyrin IX the eighth and final step in the heme biosynthetic pathway Yfh1p mediates the use of iron by Hem15p; KLTH0G15400p 1351245 8293988 KLTH0G15400g Lachancea thermotolerans CBS 6340 KLTH0G15400p XP_002555702.1 1350109 R 559295 CDS KLTH0G15422g 255718845 8293989 1351960..1353780 1 NC_013083.1 similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C Hypothetical ORF; KLTH0G15422p 1353780 8293989 KLTH0G15422g Lachancea thermotolerans CBS 6340 KLTH0G15422p XP_002555703.1 1351960 D 559295 CDS KLTH0G15444g 255718847 8293990 complement(1353833..1354624) 1 NC_013083.1 some similarities with uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; KLTH0G15444p 1354624 8293990 KLTH0G15444g Lachancea thermotolerans CBS 6340 KLTH0G15444p XP_002555704.1 1353833 R 559295 CDS KLTH0G15466g 255718849 8293991 complement(1354852..1355820) 1 NC_013083.1 weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Hypothetical ORF; KLTH0G15466p 1355820 8293991 KLTH0G15466g Lachancea thermotolerans CBS 6340 KLTH0G15466p XP_002555705.1 1354852 R 559295 CDS KLTH0G15488g 255718851 8293992 complement(1355977..1357071) 1 NC_013083.1 highly similar to uniprot|Q6Q5L1 Saccharomyces cerevisiae YLR270W DCS1 Non-essential hydrolase involved in mRNA decapping may function in a feedback mechanism to regulate deadenylation contains pyrophosphatase activity and a HIT (histidine triad) motif interacts with neutral trehalase Nth1p; KLTH0G15488p 1357071 8293992 KLTH0G15488g Lachancea thermotolerans CBS 6340 KLTH0G15488p XP_002555706.1 1355977 R 559295 CDS KLTH0G15510g 255718853 8293993 complement(join(1357312..1357922,1358028..1358061)) 1 NC_013083.1 highly similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein assembles into SNARE complex with Bet1p Bos1p and Sed5p cycles between the ER and Golgi complex involved in anterograde and retrograde transport between the ER and Golgi synaptobrevin homolog; KLTH0G15510p 1358061 8293993 KLTH0G15510g Lachancea thermotolerans CBS 6340 KLTH0G15510p XP_002555707.1 1357312 R 559295 CDS KLTH0G15532g 255718855 8293994 1358507..1359757 1 NC_013083.1 conserved hypothetical protein; KLTH0G15532p 1359757 8293994 KLTH0G15532g Lachancea thermotolerans CBS 6340 KLTH0G15532p XP_002555708.1 1358507 D 559295 CDS KLTH0G15554g 255718857 8293995 1360091..1361107 1 NC_013083.1 weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W SPP381 Suppressor of Pre-mRNA Processing mutant; U4/U6.U5-associated snRNP protein; contains a PEST proteolysis motif; KLTH0G15554p 1361107 8293995 KLTH0G15554g Lachancea thermotolerans CBS 6340 KLTH0G15554p XP_002555709.1 1360091 D 559295 CDS KLTH0G15576g 255718859 8293996 1361226..1361978 1 NC_013083.1 similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase catalyzes the second step of the riboflavin biosynthesis pathway; KLTH0G15576p 1361978 8293996 KLTH0G15576g Lachancea thermotolerans CBS 6340 KLTH0G15576p XP_002555710.1 1361226 D 559295 CDS KLTH0G15598g 255718861 8293997 complement(1362363..1363010) 1 NC_013083.1 highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27 common to RNA polymerases I II and III contacts DNA and affects transactivation; KLTH0G15598p 1363010 8293997 KLTH0G15598g Lachancea thermotolerans CBS 6340 KLTH0G15598p XP_002555711.1 1362363 R 559295 CDS KLTH0G15620g 255718863 8293998 complement(1363249..1366056) 1 NC_013083.1 similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Hypothetical ORF; KLTH0G15620p 1366056 8293998 KLTH0G15620g Lachancea thermotolerans CBS 6340 KLTH0G15620p XP_002555712.1 1363249 R 559295 CDS KLTH0G15642g 255718865 8293999 1366294..1366650 1 NC_013083.1 KLTH0G15642p 1366650 8293999 KLTH0G15642g Lachancea thermotolerans CBS 6340 KLTH0G15642p XP_002555713.1 1366294 D 559295 CDS KLTH0G15664g 255718867 8294000 complement(1366743..1367582) 1 NC_013083.1 similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit; KLTH0G15664p 1367582 8294000 KLTH0G15664g Lachancea thermotolerans CBS 6340 KLTH0G15664p XP_002555714.1 1366743 R 559295 CDS KLTH0G15686g 255718869 8294001 complement(1367997..1369052) 1 NC_013083.1 highly similar to uniprot|P00330 Saccharomyces cerevisiae YOL086C ADH1 Alcohol dehydrogenase involved in the production of certain carboxylate esters; KLTH0G15686p 1369052 8294001 KLTH0G15686g Lachancea thermotolerans CBS 6340 KLTH0G15686p XP_002555715.1 1367997 R 559295 CDS KLTH0G15708g 255718871 8294002 complement(1369238..1370194) 1 NC_013083.1 no similarity; KLTH0G15708p 1370194 8294002 KLTH0G15708g Lachancea thermotolerans CBS 6340 KLTH0G15708p XP_002555716.1 1369238 R 559295 CDS KLTH0G15730g 255718873 8294003 1371105..1372103 1 NC_013083.1 highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases; KLTH0G15730p 1372103 8294003 KLTH0G15730g Lachancea thermotolerans CBS 6340 KLTH0G15730p XP_002555717.1 1371105 D 559295 CDS KLTH0G15752g 255718875 8294004 1373153..1376047 1 NC_013083.1 similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; KLTH0G15752p 1376047 8294004 KLTH0G15752g Lachancea thermotolerans CBS 6340 KLTH0G15752p XP_002555718.1 1373153 D 559295 CDS KLTH0G15774g 255718877 8294005 1376612..1377538 1 NC_013083.1 conserved hypothetical protein; KLTH0G15774p 1377538 8294005 KLTH0G15774g Lachancea thermotolerans CBS 6340 KLTH0G15774p XP_002555719.1 1376612 D 559295 CDS KLTH0G15796g 255718879 8294006 1377878..1379431 1 NC_013083.1 conserved hypothetical protein; KLTH0G15796p 1379431 8294006 KLTH0G15796g Lachancea thermotolerans CBS 6340 KLTH0G15796p XP_002555720.1 1377878 D 559295 CDS KLTH0G15818g 255718881 8294007 1379804..1381120 1 NC_013083.1 highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor; KLTH0G15818p 1381120 8294007 KLTH0G15818g Lachancea thermotolerans CBS 6340 KLTH0G15818p XP_002555721.1 1379804 D 559295 CDS KLTH0G15840g 255718883 8294008 complement(1381355..1383748) 1 NC_013083.1 similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits; KLTH0G15840p 1383748 8294008 KLTH0G15840g Lachancea thermotolerans CBS 6340 KLTH0G15840p XP_002555722.1 1381355 R 559295 CDS KLTH0G15862g 255718885 8294009 1383921..1384919 1 NC_013083.1 similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF; KLTH0G15862p 1384919 8294009 KLTH0G15862g Lachancea thermotolerans CBS 6340 KLTH0G15862p XP_002555723.1 1383921 D 559295 CDS KLTH0G15884g 255718887 8294010 1385172..1393775 1 NC_013083.1 weakly similar to uniprot|P18963 Saccharomyces cerevisiae YBR140c IRA1 or uniprot|P19158 Saccharomyces cerevisiae YOL081w IRA2; KLTH0G15884p 1393775 8294010 KLTH0G15884g Lachancea thermotolerans CBS 6340 KLTH0G15884p XP_002555724.1 1385172 D 559295 CDS KLTH0G15906g 255718889 8294011 complement(1393845..1394681) 1 NC_013083.1 similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly; KLTH0G15906p 1394681 8294011 KLTH0G15906g Lachancea thermotolerans CBS 6340 KLTH0G15906p XP_002555725.1 1393845 R 559295 CDS KLTH0G15928g 255718891 8294012 1395084..1398293 1 NC_013083.1 similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth; KLTH0G15928p 1398293 8294012 KLTH0G15928g Lachancea thermotolerans CBS 6340 KLTH0G15928p XP_002555726.1 1395084 D 559295 CDS KLTH0G15950g 255718893 8294013 complement(1398358..1399848) 1 NC_013083.1 similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Hypothetical ORF; KLTH0G15950p 1399848 8294013 KLTH0G15950g Lachancea thermotolerans CBS 6340 KLTH0G15950p XP_002555727.1 1398358 R 559295 CDS KLTH0G15972g 255718895 8294014 1400277..1400486 1 NC_013083.1 similar to uniprot|P81451 Saccharomyces cerevisiae YOL077W-A ATP19 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase; KLTH0G15972p 1400486 8294014 KLTH0G15972g Lachancea thermotolerans CBS 6340 KLTH0G15972p XP_002555728.1 1400277 D 559295 CDS KLTH0G15994g 255718897 8294015 complement(1400685..1401569) 1 NC_013083.1 highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein involved in the biogenesis of large ribosomal subunits depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits possesses a sigma(70)-like RNA- binding motif; KLTH0G15994p 1401569 8294015 KLTH0G15994g Lachancea thermotolerans CBS 6340 KLTH0G15994p XP_002555729.1 1400685 R 559295 CDS KLTH0G16016g 255718899 8294016 1401789..1404125 1 NC_013083.1 similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met involved in mitochondrial inheritance and actin assembly; KLTH0G16016p 1404125 8294016 KLTH0G16016g Lachancea thermotolerans CBS 6340 KLTH0G16016p XP_002555730.1 1401789 D 559295 CDS KLTH0G16038g 255718901 8294017 1404292..1406121 1 NC_013083.1 similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment; KLTH0G16038p 1406121 8294017 KLTH0G16038g Lachancea thermotolerans CBS 6340 KLTH0G16038p XP_002555731.1 1404292 D 559295 CDS KLTH0G16060g 255718903 8294018 1406291..1406932 1 NC_013083.1 similar to Saccharomyces cerevisiae YDL010W Hypothetical ORF or YBR014C uniprot|P38068 Saccharomyces cerevisiae YBR014C Hypothetical ORF; KLTH0G16060p 1406932 8294018 KLTH0G16060g Lachancea thermotolerans CBS 6340 KLTH0G16060p XP_002555732.1 1406291 D 559295 CDS KLTH0G16082g 255718905 8294019 1407117..1407524 1 NC_013083.1 some similarities with uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0G16082p 1407524 8294019 KLTH0G16082g Lachancea thermotolerans CBS 6340 KLTH0G16082p XP_002555733.1 1407117 D 559295 CDS KLTH0G16104g 255718907 8294020 join(1407918..1407942,1408026..1408516) 1 NC_013083.1 some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W; KLTH0G16104p 1408516 8294020 KLTH0G16104g Lachancea thermotolerans CBS 6340 KLTH0G16104p XP_002555734.1 1407918 D 559295 CDS KLTH0G16126g 255718909 8294021 1408729..1410216 1 NC_013083.1 highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma- aminobutyrate (GABA) as a nitrogen source part of the 4- aminobutyrate and glutamate degradation pathways localized to the cytoplasm; KLTH0G16126p 1410216 8294021 KLTH0G16126g Lachancea thermotolerans CBS 6340 KLTH0G16126p XP_002555735.1 1408729 D 559295 CDS KLTH0G16148g 255718911 8294022 1410446..1411882 1 NC_013083.1 similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad55p; KLTH0G16148p 1411882 8294022 KLTH0G16148g Lachancea thermotolerans CBS 6340 KLTH0G16148p XP_002555736.1 1410446 D 559295 CDS KLTH0G16170g 255718913 8294023 complement(join(1412010..1413158,1413260..1413265)) 1 NC_013083.1 similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment targets the initiation factor TFIIIB; KLTH0G16170p 1413265 8294023 KLTH0G16170g Lachancea thermotolerans CBS 6340 KLTH0G16170p XP_002555737.1 1412010 R 559295 CDS KLTH0G16192g 255718915 8294024 complement(1413504..1415378) 1 NC_013083.1 weakly similar to uniprot|P38213 Saccharomyces cerevisiae YBR007C DSF2; KLTH0G16192p 1415378 8294024 KLTH0G16192g Lachancea thermotolerans CBS 6340 KLTH0G16192p XP_002555738.1 1413504 R 559295 CDS KLTH0G16214g 255718917 8294025 complement(1415789..1418389) 1 NC_013083.1 weakly similar to YDR006C, uniprot|P40317 Saccharomyces cerevisiae YDR006C (SOK1); KLTH0G16214p 1418389 8294025 KLTH0G16214g Lachancea thermotolerans CBS 6340 KLTH0G16214p XP_002555739.1 1415789 R 559295 CDS KLTH0G16236g 255718919 8294026 complement(1419670..1419981) 1 NC_013083.1 highly similar to uniprot|P02309 Saccharomyces cerevisiae YBR009C HHF1 and highly similar to uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; KLTH0G16236p 1419981 8294026 KLTH0G16236g Lachancea thermotolerans CBS 6340 KLTH0G16236p XP_002555740.1 1419670 R 559295 CDS KLTH0G16258g 255718921 8294027 1420557..1420967 1 NC_013083.1 highly similar to uniprot|P61830 Saccharomyces cerevisiae YBR010W One of two identical histone H3 proteins ; core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; KLTH0G16258p 1420967 8294027 KLTH0G16258g Lachancea thermotolerans CBS 6340 KLTH0G16258p XP_002555741.1 1420557 D 559295 CDS KLTH0G16280g 255718923 8294028 1422058..1422777 1 NC_013083.1 similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis in 2004 the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); KLTH0G16280p 1422777 8294028 KLTH0G16280g Lachancea thermotolerans CBS 6340 KLTH0G16280p XP_002555742.1 1422058 D 559295 CDS KLTH0G16302g 255718925 8294029 complement(1422823..1423683) 1 NC_013083.1 highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase) catalyzes the rapid exchange of oxygens from Pi with water highly expressed and essential for viability active-site residues show identity to those from E. coli PPase; KLTH0G16302p 1423683 8294029 KLTH0G16302g Lachancea thermotolerans CBS 6340 KLTH0G16302p XP_002555743.1 1422823 R 559295 CDS KLTH0G16324g 255718927 8294030 complement(1424057..1424800) 1 NC_013083.1 some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W; KLTH0G16324p 1424800 8294030 KLTH0G16324g Lachancea thermotolerans CBS 6340 KLTH0G16324p XP_002555744.1 1424057 R 559295 CDS KLTH0G16346g 255718929 8294031 1424922..1426229 1 NC_013083.1 similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG- V which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis the authentic non-tagged protein was localized to mitochondria; KLTH0G16346p 1426229 8294031 KLTH0G16346g Lachancea thermotolerans CBS 6340 KLTH0G16346p XP_002555745.1 1424922 D 559295 CDS KLTH0G16368g 255718931 8294032 complement(1427062..1428474) 1 NC_013083.1 highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; KLTH0G16368p 1428474 8294032 KLTH0G16368g Lachancea thermotolerans CBS 6340 KLTH0G16368p XP_002555746.1 1427062 R 559295 CDS KLTH0G16390g 255718933 8294033 1428577..1429431 1 NC_013083.1 similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis participates in endoplasmic reticulum (ER) protein sorting; KLTH0G16390p 1429431 8294033 KLTH0G16390g Lachancea thermotolerans CBS 6340 KLTH0G16390p XP_002555747.1 1428577 D 559295 CDS KLTH0G16412g 255718935 8294034 complement(1429587..1430198) 1 NC_013083.1 similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Yeast Ran Binder #1 suppressor of FUS1 homolog of mouse HTF9a and human RanBP1 nuclear GTPase- activating protein for Ran; KLTH0G16412p 1430198 8294034 KLTH0G16412g Lachancea thermotolerans CBS 6340 KLTH0G16412p XP_002555748.1 1429587 R 559295 CDS KLTH0G16434g 255718937 8294035 1430288..1432624 1 NC_013083.1 highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C NTH1 Neutral trehalase degrades trehalose required for thermotolerance and may mediate resistance to other cellular stresses may be phosphorylated by Cdc28p; KLTH0G16434p 1432624 8294035 KLTH0G16434g Lachancea thermotolerans CBS 6340 KLTH0G16434p XP_002555749.1 1430288 D 559295 CDS KLTH0G16478g 255718939 8294037 join(1433455..1433496,1433553..1433825) 1 NC_013083.1 highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis; KLTH0G16478p 1433825 8294037 KLTH0G16478g Lachancea thermotolerans CBS 6340 KLTH0G16478p XP_002555750.1 1433455 D 559295 CDS KLTH0G16500g 255718941 8294038 complement(1433965..1434363) 1 NC_013083.1 similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; KLTH0G16500p 1434363 8294038 KLTH0G16500g Lachancea thermotolerans CBS 6340 KLTH0G16500p XP_002555751.1 1433965 R 559295 CDS KLTH0G16522g 255718943 8294039 1434882..1435280 1 NC_013083.1 similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; KLTH0G16522p 1435280 8294039 KLTH0G16522g Lachancea thermotolerans CBS 6340 KLTH0G16522p XP_002555752.1 1434882 D 559295 CDS KLTH0G16544g 255718945 8294040 complement(1435479..1436705) 1 NC_013083.1 similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation; KLTH0G16544p 1436705 8294040 KLTH0G16544g Lachancea thermotolerans CBS 6340 KLTH0G16544p XP_002555753.1 1435479 R 559295 CDS KLTH0G16566g 255718947 8294041 1436819..1437430 1 NC_013083.1 similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins likely component of the INO80 complex which is an ATP-dependent chromatin-remodeling complex; KLTH0G16566p 1437430 8294041 KLTH0G16566g Lachancea thermotolerans CBS 6340 KLTH0G16566p XP_002555754.1 1436819 D 559295 CDS KLTH0G16588g 255718949 8294042 complement(1437552..1445048) 1 NC_013083.1 similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Possible snoRNA-binding protein based on computational analysis of large-scale protein- protein interaction data; KLTH0G16588p 1445048 8294042 KLTH0G16588g Lachancea thermotolerans CBS 6340 KLTH0G16588p XP_002555755.1 1437552 R 559295 CDS KLTH0G16610g 255718951 8294043 complement(1445310..1447025) 1 NC_013083.1 similar to uniprot|Q05325 Saccharomyces cerevisiae YDL003W MCD1 Essential protein required for sister chromatid cohesion in mitosis and meiosis subunit of the cohesin complex expression is cell cycle regulated and peaks in S phase; KLTH0G16610p 1447025 8294043 KLTH0G16610g Lachancea thermotolerans CBS 6340 KLTH0G16610p XP_002555756.1 1445310 R 559295 CDS KLTH0G16632g 255718953 8294044 complement(1448734..1449378) 1 NC_013083.1 similar to uniprot|Q12165 Saccharomyces cerevisiae YDL004W ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis; KLTH0G16632p 1449378 8294044 KLTH0G16632g Lachancea thermotolerans CBS 6340 KLTH0G16632p XP_002555757.1 1448734 R 559295 CDS KLTH0G16654g 255718955 8294045 1449516..1450400 1 NC_013083.1 weakly similar to uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex; KLTH0G16654p 1450400 8294045 KLTH0G16654g Lachancea thermotolerans CBS 6340 KLTH0G16654p XP_002555758.1 1449516 D 559295 CDS KLTH0G16676g 255718957 8294046 complement(1450479..1451363) 1 NC_013083.1 highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C) inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p mutation delays mitochondrial inheritance deletion reveals defects in precursor tRNA splicing sporulation and cell separation; KLTH0G16676p 1451363 8294046 KLTH0G16676g Lachancea thermotolerans CBS 6340 KLTH0G16676p XP_002555759.1 1450479 R 559295 CDS KLTH0G16698g 255718959 8294047 complement(join(1451637..1452941,1453023..1453085)) 1 NC_013083.1 highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for normal peptide hydrolysis by the core 20S particle; KLTH0G16698p 1453085 8294047 KLTH0G16698g Lachancea thermotolerans CBS 6340 KLTH0G16698p XP_002555760.1 1451637 R 559295 CDS KLTH0G16764g 255718961 8294050 complement(1454815..1456947) 1 NC_013083.1 similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF; KLTH0G16764p 1456947 8294050 KLTH0G16764g Lachancea thermotolerans CBS 6340 KLTH0G16764p XP_002555761.1 1454815 R 559295 CDS KLTH0G16786g 255718963 8294051 complement(1457364..1458389) 1 NC_013083.1 similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C Hypothetical ORF; KLTH0G16786p 1458389 8294051 KLTH0G16786g Lachancea thermotolerans CBS 6340 KLTH0G16786p XP_002555762.1 1457364 R 559295 CDS KLTH0G16808g 255718965 8294052 1458675..1459718 1 NC_013083.1 similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W Hypothetical ORF; KLTH0G16808p 1459718 8294052 KLTH0G16808g Lachancea thermotolerans CBS 6340 KLTH0G16808p XP_002555763.1 1458675 D 559295 CDS KLTH0G16830g 255718967 8294053 complement(1459720..1460724) 1 NC_013083.1 no similarity; KLTH0G16830p 1460724 8294053 KLTH0G16830g Lachancea thermotolerans CBS 6340 KLTH0G16830p XP_002555764.1 1459720 R 559295 CDS KLTH0G16852g 255718969 8294054 complement(1461207..1463183) 1 NC_013083.1 weakly similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex maintains cohesion between sister chromatids during meiosis I maintains cohesion between centromeres of sister chromatids until meiosis II homolog of S. pombe Rec8p; KLTH0G16852p 1463183 8294054 KLTH0G16852g Lachancea thermotolerans CBS 6340 KLTH0G16852p XP_002555765.1 1461207 R 559295 CDS KLTH0G16874g 255718971 8294055 1463403..1464086 1 NC_013083.1 similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far8p Far9p Far10p and Far11p; KLTH0G16874p 1464086 8294055 KLTH0G16874g Lachancea thermotolerans CBS 6340 KLTH0G16874p XP_002555766.1 1463403 D 559295 CDS KLTH0G16940g 255718973 8294058 1465378..1466574 1 NC_013083.1 similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron; KLTH0G16940p 1466574 8294058 KLTH0G16940g Lachancea thermotolerans CBS 6340 KLTH0G16940p XP_002555767.1 1465378 D 559295 CDS KLTH0G16962g 255718975 8294059 1466851..1467402 1 NC_013083.1 no similarity; KLTH0G16962p 1467402 8294059 KLTH0G16962g Lachancea thermotolerans CBS 6340 KLTH0G16962p XP_002555768.1 1466851 D 559295 CDS KLTH0G16984g 255718977 8294060 1468135..1469979 1 NC_013083.1 weakly similar to uniprot|Q12753 Saccharomyces cerevisiae YPR008W; KLTH0G16984p 1469979 8294060 KLTH0G16984g Lachancea thermotolerans CBS 6340 KLTH0G16984p XP_002555769.1 1468135 D 559295 CDS KLTH0G17006g 255718979 8294061 complement(1470134..1471393) 1 NC_013083.1 similar to uniprot|P53107 Saccharomyces cerevisiae YGL164C YRB30 Competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) able to form trimeric complexes with RanGTP and some of the karyopherins inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran.; KLTH0G17006p 1471393 8294061 KLTH0G17006g Lachancea thermotolerans CBS 6340 KLTH0G17006p XP_002555770.1 1470134 R 559295 CDS KLTH0G17028g 255718981 8294062 complement(1471506..1474508) 1 NC_013083.1 similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis member of the SWI/SNF family; KLTH0G17028p 1474508 8294062 KLTH0G17028g Lachancea thermotolerans CBS 6340 KLTH0G17028p XP_002555771.1 1471506 R 559295 CDS KLTH0G17050g 255718983 8294063 1475875..1477173 1 NC_013083.1 some similarities with uniprot|Q12286 Saccharomyces cerevisiae YPR009W SUT2 Involved in sterol uptake homologous to SUT1; KLTH0G17050p 1477173 8294063 KLTH0G17050g Lachancea thermotolerans CBS 6340 KLTH0G17050p XP_002555772.1 1475875 D 559295 CDS KLTH0G17072g 255718985 8294064 complement(1477963..1478754) 1 NC_013083.1 conserved hypothetical protein; KLTH0G17072p 1478754 8294064 KLTH0G17072g Lachancea thermotolerans CBS 6340 KLTH0G17072p XP_002555773.1 1477963 R 559295 CDS KLTH0G17094g 255718987 8294065 1479070..1479906 1 NC_013083.1 conserved hypothetical protein; KLTH0G17094p 1479906 8294065 KLTH0G17094g Lachancea thermotolerans CBS 6340 KLTH0G17094p XP_002555774.1 1479070 D 559295 CDS KLTH0G17116g 255718989 8294066 1480226..1481431 1 NC_013083.1 similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Protein required for respiratory growth null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start; KLTH0G17116p 1481431 8294066 KLTH0G17116g Lachancea thermotolerans CBS 6340 KLTH0G17116p XP_002555775.1 1480226 D 559295 CDS KLTH0G17138g 255718991 8294067 complement(1481458..1484277) 1 NC_013083.1 highly similar to uniprot|P13586 Saccharomyces cerevisiae YGL167C PMR1 High affinity Ca2 /Mn2 P-type ATPase required for Ca2 and Mn2 transport into Golgi involved in Ca2 dependent protein sorting and processing mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; KLTH0G17138p 1484277 8294067 KLTH0G17138g Lachancea thermotolerans CBS 6340 KLTH0G17138p XP_002555776.1 1481458 R 559295 CDS KLTH0G17160g 255718993 8294068 complement(1484609..1488202) 1 NC_013083.1 highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135; KLTH0G17160p 1488202 8294068 KLTH0G17160g Lachancea thermotolerans CBS 6340 KLTH0G17160p XP_002555777.1 1484609 R 559295 CDS KLTH0G17204g 255718995 8294070 1489765..1490835 1 NC_013083.1 some similarities with uniprot|Q04951 Saccharomyces cerevisiae YMR305C; KLTH0G17204p 1490835 8294070 KLTH0G17204g Lachancea thermotolerans CBS 6340 KLTH0G17204p XP_002555778.1 1489765 D 559295 CDS KLTH0G17226g 255718997 8294071 1491300..1492526 1 NC_013083.1 some similarities with uniprot|P36027 Saccharomyces cerevisiae YLR332W MID2 Protein required for mating; KLTH0G17226p 1492526 8294071 KLTH0G17226g Lachancea thermotolerans CBS 6340 KLTH0G17226p XP_002555779.1 1491300 D 559295 CDS KLTH0G17270g 255718999 8294073 complement(1494275..1494988) 1 NC_013083.1 highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes; KLTH0G17270p 1494988 8294073 KLTH0G17270g Lachancea thermotolerans CBS 6340 KLTH0G17270p XP_002555780.1 1494275 R 559295 CDS KLTH0G17292g 255719001 8294074 1495922..1497112 1 NC_013083.1 highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Acetohydroxyacid reductoisomerase mitochondrial protein involved in branched-chain amino acid biosynthesis also required for maintenance of wild- type mitochondrial DNA; KLTH0G17292p 1497112 8294074 KLTH0G17292g Lachancea thermotolerans CBS 6340 KLTH0G17292p XP_002555781.1 1495922 D 559295 CDS KLTH0G17314g 255719003 8294075 1497839..1498507 1 NC_013083.1 conserved hypothetical protein; KLTH0G17314p 1498507 8294075 KLTH0G17314g Lachancea thermotolerans CBS 6340 KLTH0G17314p XP_002555782.1 1497839 D 559295 CDS KLTH0G17336g 255719005 8294076 1500141..1501598 1 NC_013083.1 some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator; KLTH0G17336p 1501598 8294076 KLTH0G17336g Lachancea thermotolerans CBS 6340 KLTH0G17336p XP_002555783.1 1500141 D 559295 CDS KLTH0G17358g 255719007 8294077 1503299..1506835 1 NC_013083.1 conserved hypothetical protein; KLTH0G17358p 1506835 8294077 KLTH0G17358g Lachancea thermotolerans CBS 6340 KLTH0G17358p XP_002555784.1 1503299 D 559295 CDS KLTH0G17380g 255719009 8294078 1508114..1509115 1 NC_013083.1 highly similar to uniprot|P15019 Saccharomyces cerevisiae YLR354C TAL1 Transaldolase enzyme in the pentose phosphate pathway; KLTH0G17380p 1509115 8294078 KLTH0G17380g Lachancea thermotolerans CBS 6340 KLTH0G17380p XP_002555785.1 1508114 D 559295 CDS KLTH0G17402g 255719011 8294079 complement(1509230..1510096) 1 NC_013083.1 weakly similar to uniprot|P53227 Saccharomyces cerevisiae YGR042W Hypothetical ORF; KLTH0G17402p 1510096 8294079 KLTH0G17402g Lachancea thermotolerans CBS 6340 KLTH0G17402p XP_002555786.1 1509230 R 559295 CDS KLTH0G17424g 255719013 8294080 1510444..1511391 1 NC_013083.1 similar to uniprot|P40507 Saccharomyces cerevisiae YIL079C; KLTH0G17424p 1511391 8294080 KLTH0G17424g Lachancea thermotolerans CBS 6340 KLTH0G17424p XP_002555787.1 1510444 D 559295 CDS KLTH0G17446g 255719015 8294081 complement(1511859..1513121) 1 NC_013083.1 conserved hypothetical protein; KLTH0G17446p 1513121 8294081 KLTH0G17446g Lachancea thermotolerans CBS 6340 KLTH0G17446p XP_002555788.1 1511859 R 559295 CDS KLTH0G17468g 255719017 8294082 complement(1513882..1515498) 1 NC_013083.1 some similarities with uniprot|P41698 Saccharomyces cerevisiae YLR353W BUD8 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern and bud at the proximal pole; KLTH0G17468p 1515498 8294082 KLTH0G17468g Lachancea thermotolerans CBS 6340 KLTH0G17468p XP_002555789.1 1513882 R 559295 CDS KLTH0G17490g 255719019 8294083 complement(1515948..1518128) 1 NC_013083.1 similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W Hypothetical ORF; KLTH0G17490p 1518128 8294083 KLTH0G17490g Lachancea thermotolerans CBS 6340 KLTH0G17490p XP_002555790.1 1515948 R 559295 CDS KLTH0G17512g 255719021 8294084 complement(1518329..1519426) 1 NC_013083.1 highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; KLTH0G17512p 1519426 8294084 KLTH0G17512g Lachancea thermotolerans CBS 6340 KLTH0G17512p XP_002555791.1 1518329 R 559295 CDS KLTH0G17534g 255719023 8294085 1519882..1520775 1 NC_013083.1 highly similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C; KLTH0G17534p 1520775 8294085 KLTH0G17534g Lachancea thermotolerans CBS 6340 KLTH0G17534p XP_002555792.1 1519882 D 559295 CDS KLTH0G17556g 255719025 8294086 complement(1520896..1521501) 1 NC_013083.1 similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W; KLTH0G17556p 1521501 8294086 KLTH0G17556g Lachancea thermotolerans CBS 6340 KLTH0G17556p XP_002555793.1 1520896 R 559295 CDS KLTH0G17578g 255719027 8294087 1522947..1523207 1 NC_013083.1 similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding; KLTH0G17578p 1523207 8294087 KLTH0G17578g Lachancea thermotolerans CBS 6340 KLTH0G17578p XP_002555794.1 1522947 D 559295 CDS KLTH0G17600g 255719029 8294088 1523631..1526225 1 NC_013083.1 highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex; KLTH0G17600p 1526225 8294088 KLTH0G17600g Lachancea thermotolerans CBS 6340 KLTH0G17600p XP_002555795.1 1523631 D 559295 CDS KLTH0G17622g 255719031 8294089 1526713..1527432 1 NC_013083.1 similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation; KLTH0G17622p 1527432 8294089 KLTH0G17622g Lachancea thermotolerans CBS 6340 KLTH0G17622p XP_002555796.1 1526713 D 559295 CDS KLTH0G17644g 255719033 8294090 complement(1527518..1529167) 1 NC_013083.1 similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W Hypothetical ORF; KLTH0G17644p 1529167 8294090 KLTH0G17644g Lachancea thermotolerans CBS 6340 KLTH0G17644p XP_002555797.1 1527518 R 559295 CDS KLTH0G17666g 255719035 8294091 complement(join(1529587..1529951,1530320..1530338)) 1 NC_013083.1 highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W; KLTH0G17666p 1530338 8294091 KLTH0G17666g Lachancea thermotolerans CBS 6340 KLTH0G17666p XP_002555798.1 1529587 R 559295 CDS KLTH0G17710g 255719037 8294093 1531495..1532238 1 NC_013083.1 similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria; KLTH0G17710p 1532238 8294093 KLTH0G17710g Lachancea thermotolerans CBS 6340 KLTH0G17710p XP_002555799.1 1531495 D 559295 CDS KLTH0G17732g 255719039 8294094 complement(1532367..1534013) 1 NC_013083.1 similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p; KLTH0G17732p 1534013 8294094 KLTH0G17732g Lachancea thermotolerans CBS 6340 KLTH0G17732p XP_002555800.1 1532367 R 559295 CDS KLTH0G17754g 255719041 8294095 complement(1534396..1540092) 1 NC_013083.1 highly similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1; KLTH0G17754p 1540092 8294095 KLTH0G17754g Lachancea thermotolerans CBS 6340 KLTH0G17754p XP_002555801.1 1534396 R 559295 CDS KLTH0G17776g 255719043 8294096 complement(1541831..1542892) 1 NC_013083.1 similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF; KLTH0G17776p 1542892 8294096 KLTH0G17776g Lachancea thermotolerans CBS 6340 KLTH0G17776p XP_002555802.1 1541831 R 559295 CDS KLTH0G17798g 255719045 8294097 complement(1543360..1545480) 1 NC_013083.1 conserved hypothetical protein; KLTH0G17798p 1545480 8294097 KLTH0G17798g Lachancea thermotolerans CBS 6340 KLTH0G17798p XP_002555803.1 1543360 R 559295 CDS KLTH0G17820g 255719047 8294098 complement(1545777..1546712) 1 NC_013083.1 highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302; KLTH0G17820p 1546712 8294098 KLTH0G17820g Lachancea thermotolerans CBS 6340 KLTH0G17820p XP_002555804.1 1545777 R 559295 CDS KLTH0G17842g 255719049 8294099 1547619..1548137 1 NC_013083.1 weakly similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; KLTH0G17842p 1548137 8294099 KLTH0G17842g Lachancea thermotolerans CBS 6340 KLTH0G17842p XP_002555805.1 1547619 D 559295 CDS KLTH0G17864g 255719051 8294100 1548498..1549988 1 NC_013083.1 conserved hypothetical protein; KLTH0G17864p 1549988 8294100 KLTH0G17864g Lachancea thermotolerans CBS 6340 KLTH0G17864p XP_002555806.1 1548498 D 559295 CDS KLTH0G17886g 255719053 8294101 1550451..1552865 1 NC_013083.1 some similarities with uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin; KLTH0G17886p 1552865 8294101 KLTH0G17886g Lachancea thermotolerans CBS 6340 KLTH0G17886p XP_002555807.1 1550451 D 559295 CDS KLTH0G17908g 255719055 8294102 complement(join(1552964..1553420,1553489..1553574)) 1 NC_013083.1 similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space has a role in the maturation of cytosolic iron-sulfur proteins ortholog of human hepatopoietin (ALR); KLTH0G17908p 1553574 8294102 KLTH0G17908g Lachancea thermotolerans CBS 6340 KLTH0G17908p XP_002555808.1 1552964 R 559295 CDS KLTH0G17930g 255719057 8294103 complement(1553688..1554764) 1 NC_013083.1 highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane- spanning ATPase; KLTH0G17930p 1554764 8294103 KLTH0G17930g Lachancea thermotolerans CBS 6340 KLTH0G17930p XP_002555809.1 1553688 R 559295 CDS KLTH0G17952g 255719059 8294104 1555700..1558927 1 NC_013083.1 some similarities with uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway; KLTH0G17952p 1558927 8294104 KLTH0G17952g Lachancea thermotolerans CBS 6340 KLTH0G17952p XP_002555810.1 1555700 D 559295 CDS KLTH0G17974g 255719061 8294105 complement(1559048..1561270) 1 NC_013083.1 similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization; KLTH0G17974p 1561270 8294105 KLTH0G17974g Lachancea thermotolerans CBS 6340 KLTH0G17974p XP_002555811.1 1559048 R 559295 CDS KLTH0G18018g 255719063 8294106 1561912..1562235 1 NC_013083.1 some similarities with uniprot|P07282 Saccharomyces cerevisiae YLR333c RPS31B and some similarites with uniprot|P07282 Saccharomyces cerevisiae YGR027c RPS31A; KLTH0G18018p 1562235 8294106 KLTH0G18018g Lachancea thermotolerans CBS 6340 KLTH0G18018p XP_002555812.1 1561912 D 559295 CDS KLTH0G18106g 255719065 8294190 complement(1563084..1563881) 1 NC_013083.1 similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0G18106p 1563881 8294190 KLTH0G18106g Lachancea thermotolerans CBS 6340 KLTH0G18106p XP_002555813.1 1563084 R 559295 CDS KLTH0G18150g 255719067 8294109 complement(1564780..1569444) 1 NC_013083.1 similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF; KLTH0G18150p 1569444 8294109 KLTH0G18150g Lachancea thermotolerans CBS 6340 KLTH0G18150p XP_002555814.1 1564780 R 559295 CDS KLTH0G18172g 255719069 8294110 1569714..1570334 1 NC_013083.1 some similarities with uniprot|Q06485 Saccharomyces cerevisiae YLR356W Hypothetical ORF; KLTH0G18172p 1570334 8294110 KLTH0G18172g Lachancea thermotolerans CBS 6340 KLTH0G18172p XP_002555815.1 1569714 D 559295 CDS KLTH0G18194g 255719071 8294111 1570885..1572132 1 NC_013083.1 weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 The authentic non-tagged protein was localized to the mitochondria; KLTH0G18194p 1572132 8294111 KLTH0G18194g Lachancea thermotolerans CBS 6340 KLTH0G18194p XP_002555816.1 1570885 D 559295 CDS KLTH0G18216g 255719073 8294112 complement(1572457..1573212) 1 NC_013083.1 similar to uniprot|P53234 Saccharomyces cerevisiae YGR053C Hypothetical ORF; KLTH0G18216p 1573212 8294112 KLTH0G18216g Lachancea thermotolerans CBS 6340 KLTH0G18216p XP_002555817.1 1572457 R 559295 CDS KLTH0G18238g 255719075 8294113 1573902..1575782 1 NC_013083.1 similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W yeast homolog of mammalian eIF2A; KLTH0G18238p 1575782 8294113 KLTH0G18238g Lachancea thermotolerans CBS 6340 KLTH0G18238p XP_002555818.1 1573902 D 559295 CDS KLTH0G18260g 255719077 8294114 1576244..1576483 1 NC_013083.1 conserved hypothetical protein; KLTH0G18260p 1576483 8294114 KLTH0G18260g Lachancea thermotolerans CBS 6340 KLTH0G18260p XP_002555819.1 1576244 D 559295 CDS KLTH0G18282g 255719079 8294115 complement(1576512..1577558) 1 NC_013083.1 similar to uniprot|P43568 Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle phosphorylates and activates Cdc28p nucleotide-binding pocket differs significantly from those of most other protein kinases; KLTH0G18282p 1577558 8294115 KLTH0G18282g Lachancea thermotolerans CBS 6340 KLTH0G18282p XP_002555820.1 1576512 R 559295 CDS KLTH0G18304g 255719081 8294116 complement(1577921..1578994) 1 NC_013083.1 similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase catalyzes the introduction of a C-5(6) double bond into episterol a precursor in ergosterol biosynthesis mutants are viable but cannot grow on non-fermentable carbon sources; KLTH0G18304p 1578994 8294116 KLTH0G18304g Lachancea thermotolerans CBS 6340 KLTH0G18304p XP_002555821.1 1577921 R 559295 CDS KLTH0G18326g 255719083 8294117 complement(1579374..1580183) 1 NC_013083.1 similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of the evolutionarily- conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation putative ABC ATPase interacts with Ssn2p Ssn3p and Ssn8p; KLTH0G18326p 1580183 8294117 KLTH0G18326g Lachancea thermotolerans CBS 6340 KLTH0G18326p XP_002555822.1 1579374 R 559295 CDS KLTH0G18348g 255719085 8294118 1581039..1582844 1 NC_013083.1 similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA- like complex SLIK/SALSA required for SAGA-mediated inhibition at some promoters; KLTH0G18348p 1582844 8294118 KLTH0G18348g Lachancea thermotolerans CBS 6340 KLTH0G18348p XP_002555823.1 1581039 D 559295 CDS KLTH0G18370g 255719087 8294119 complement(1582948..1584486) 1 NC_013083.1 weakly similar to uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p Ypt31p and Ypt32p involved in the regulation of ER to Golgi vesicle transport; KLTH0G18370p 1584486 8294119 KLTH0G18370g Lachancea thermotolerans CBS 6340 KLTH0G18370p XP_002555824.1 1582948 R 559295 CDS KLTH0G18392g 255719089 8294120 complement(1585039..1585971) 1 NC_013083.1 conserved hypothetical protein; KLTH0G18392p 1585971 8294120 KLTH0G18392g Lachancea thermotolerans CBS 6340 KLTH0G18392p XP_002555825.1 1585039 R 559295 CDS KLTH0G18414g 255719091 8294121 complement(1587483..1588529) 1 NC_013083.1 some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; KLTH0G18414p 1588529 8294121 KLTH0G18414g Lachancea thermotolerans CBS 6340 KLTH0G18414p XP_002555826.1 1587483 R 559295 CDS KLTH0G18436g 255719093 8294122 complement(1589213..1590229) 1 NC_013083.1 conserved hypothetical protein; KLTH0G18436p 1590229 8294122 KLTH0G18436g Lachancea thermotolerans CBS 6340 KLTH0G18436p XP_002555827.1 1589213 R 559295 CDS KLTH0G18458g 255719095 8294123 complement(1591992..1592729) 1 NC_013083.1 no similarity; KLTH0G18458p 1592729 8294123 KLTH0G18458g Lachancea thermotolerans CBS 6340 KLTH0G18458p XP_002555828.1 1591992 R 559295 CDS KLTH0G18480g 255719097 8294124 1593284..1595611 1 NC_013083.1 weakly similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Hypothetical ORF; KLTH0G18480p 1595611 8294124 KLTH0G18480g Lachancea thermotolerans CBS 6340 KLTH0G18480p XP_002555829.1 1593284 D 559295 CDS KLTH0G18502g 255719099 8294125 complement(1596141..1597550) 1 NC_013083.1 highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 serine hydroxymethyltransferase; KLTH0G18502p 1597550 8294125 KLTH0G18502g Lachancea thermotolerans CBS 6340 KLTH0G18502p XP_002555830.1 1596141 R 559295 CDS KLTH0G18524g 255719101 8294126 complement(1598612..1599724) 1 NC_013083.1 similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W; KLTH0G18524p 1599724 8294126 KLTH0G18524g Lachancea thermotolerans CBS 6340 KLTH0G18524p XP_002555831.1 1598612 R 559295 CDS KLTH0G18546g 255719103 8294127 complement(1599892..1600743) 1 NC_013083.1 conserved hypothetical protein; KLTH0G18546p 1600743 8294127 KLTH0G18546g Lachancea thermotolerans CBS 6340 KLTH0G18546p XP_002555832.1 1599892 R 559295 CDS KLTH0G18568g 255719105 8294128 complement(1601303..1602010) 1 NC_013083.1 some similarities with uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response via UPRE binding and membrane biogenesis ER stress-induced splicing pathway utilizing Ire1p Trl1p and Ada5p facilitates efficient Hac1p synthesis; KLTH0G18568p 1602010 8294128 KLTH0G18568g Lachancea thermotolerans CBS 6340 KLTH0G18568p XP_002555833.1 1601303 R 559295 CDS KLTH0G18590g 255719107 8294129 complement(1602472..1603443) 1 NC_013083.1 similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 RNA exonuclease required for U4 snRNA maturation functions redundantly with Rnh70p in 5.8S rRNA maturation and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases; KLTH0G18590p 1603443 8294129 KLTH0G18590g Lachancea thermotolerans CBS 6340 KLTH0G18590p XP_002555834.1 1602472 R 559295 CDS KLTH0G18612g 255719109 8294130 1604066..1608640 1 NC_013083.1 similar to uniprot|P43565 Saccharomyces cerevisiae YFL033C RIM15 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients specifically the establishment of stationary phase originally identified as a regulator of IME2; KLTH0G18612p 1608640 8294130 KLTH0G18612g Lachancea thermotolerans CBS 6340 KLTH0G18612p XP_002555835.1 1604066 D 559295 CDS KLTH0G18634g 255719111 8294131 1608852..1610633 1 NC_013083.1 highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl- tRNA synthetase, forms a tetramer with Frs2p to generate the active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence,but substrate binding is similar and similar to gnl|GLV|YALI0E22979g-gnl|GLV|DEHA0F08404g; KLTH0G18634p 1610633 8294131 KLTH0G18634g Lachancea thermotolerans CBS 6340 KLTH0G18634p XP_002555836.1 1608852 D 559295 CDS KLTH0G18656g 255719113 8294132 complement(1610715..1613588) 1 NC_013083.1 similar to uniprot|P43564 Saccharomyces cerevisiae YFL034W Possible integral membrane protein that interacts with Rpp0p which is a component of the ribosomal stalk; KLTH0G18656p 1613588 8294132 KLTH0G18656g Lachancea thermotolerans CBS 6340 KLTH0G18656p XP_002555837.1 1610715 R 559295 CDS KLTH0G18678g 255719115 8294133 join(1613950..1613961,1614184..1614531) 1 NC_013083.1 similar to uniprot|P05749 Saccharomyces cerevisiae YLR061W; KLTH0G18678p 1614531 8294133 KLTH0G18678g Lachancea thermotolerans CBS 6340 KLTH0G18678p XP_002555838.1 1613950 D 559295 CDS KLTH0G18700g 255719117 8294134 1614926..1615882 1 NC_013083.1 similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Hypothetical ORF; KLTH0G18700p 1615882 8294134 KLTH0G18700g Lachancea thermotolerans CBS 6340 KLTH0G18700p XP_002555839.1 1614926 D 559295 CDS KLTH0G18722g 255719119 8294135 join(1616091..1616113,1616184..1616997) 1 NC_013083.1 similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2; KLTH0G18722p 1616997 8294135 KLTH0G18722g Lachancea thermotolerans CBS 6340 KLTH0G18722p XP_002555840.1 1616091 D 559295 CDS KLTH0G18744g 255719121 8294136 complement(1617132..1621001) 1 NC_013083.1 similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W; KLTH0G18744p 1621001 8294136 KLTH0G18744g Lachancea thermotolerans CBS 6340 KLTH0G18744p XP_002555841.1 1617132 R 559295 CDS KLTH0G18766g 255719123 8294137 complement(join(1621391..1622728,1622895..1622906)) 1 NC_013083.1 highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin associates with alpha- tubulin (Tub1p and Tub3p) to form tubulin dimer which polymerizes to form microtubules; KLTH0G18766p 1622906 8294137 KLTH0G18766g Lachancea thermotolerans CBS 6340 KLTH0G18766p XP_002555842.1 1621391 R 559295 CDS KLTH0G18788g 255719125 8294138 1624218..1624832 1 NC_013083.1 highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Ras-like small GTPase involved in the ER-to-Golgi step of the secretory pathway complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); KLTH0G18788p 1624832 8294138 KLTH0G18788g Lachancea thermotolerans CBS 6340 KLTH0G18788p XP_002555843.1 1624218 D 559295 CDS KLTH0G18810g 255719127 8294139 complement(1624928..1625449) 1 NC_013083.1 similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Hypothetical ORF; KLTH0G18810p 1625449 8294139 KLTH0G18810g Lachancea thermotolerans CBS 6340 KLTH0G18810p XP_002555844.1 1624928 R 559295 CDS KLTH0G18832g 255719129 8294140 join(1626178..1626187,1626854..1627971) 1 NC_013083.1 highly similar to uniprot|P60010 Saccharomyces cerevisiae YFL039C ACT1 Actin structural protein involved in cell polarization endocytosis and other cytoskeletal functions; KLTH0G18832p 1627971 8294140 KLTH0G18832g Lachancea thermotolerans CBS 6340 KLTH0G18832p XP_002555845.1 1626178 D 559295 CDS KLTH0G18854g 255719131 8294141 complement(1628440..1629948) 1 NC_013083.1 similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W Hypothetical ORF; KLTH0G18854p 1629948 8294141 KLTH0G18854g Lachancea thermotolerans CBS 6340 KLTH0G18854p XP_002555846.1 1628440 R 559295 CDS KLTH0G18876g 255719133 8294142 join(1630242..1630393,1630451..1630895) 1 NC_013083.1 similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC22/23; KLTH0G18876p 1630895 8294142 KLTH0G18876g Lachancea thermotolerans CBS 6340 KLTH0G18876p XP_002555847.1 1630242 D 559295 CDS KLTH0G18898g 255719135 8294143 complement(1631048..1633873) 1 NC_013083.1 similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA also influences stability of intron-containing COX1 primary transcripts located in the mitochondrial inner membrane; KLTH0G18898p 1633873 8294143 KLTH0G18898g Lachancea thermotolerans CBS 6340 KLTH0G18898p XP_002555848.1 1631048 R 559295 CDS KLTH0G18920g 255719137 8294144 1634089..1634526 1 NC_013083.1 similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts; KLTH0G18920p 1634526 8294144 KLTH0G18920g Lachancea thermotolerans CBS 6340 KLTH0G18920p XP_002555849.1 1634089 D 559295 CDS KLTH0G18942g 255719139 8294145 complement(1634626..1636917) 1 NC_013083.1 highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 mitochondrial elongation factor G- like protein; KLTH0G18942p 1636917 8294145 KLTH0G18942g Lachancea thermotolerans CBS 6340 KLTH0G18942p XP_002555850.1 1634626 R 559295 CDS KLTH0G18964g 255719141 8294146 complement(1637102..1638952) 1 NC_013083.1 similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W; KLTH0G18964p 1638952 8294146 KLTH0G18964g Lachancea thermotolerans CBS 6340 KLTH0G18964p XP_002555851.1 1637102 R 559295 CDS KLTH0G18986g 255719143 8294147 complement(1639254..1640318) 1 NC_013083.1 similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase expression is induced in the presence of sorbitol; KLTH0G18986p 1640318 8294147 KLTH0G18986g Lachancea thermotolerans CBS 6340 KLTH0G18986p XP_002555852.1 1639254 R 559295 CDS KLTH0G19008g 255719145 8294148 complement(1641134..1644121) 1 NC_013083.1 similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Component of RNA polymerase II holoenzyme/mediator complex affects chromatin structure and transcriptional regulation of diverse genes required for glucose repression HO repression RME1 repression and sporulation; KLTH0G19008p 1644121 8294148 KLTH0G19008g Lachancea thermotolerans CBS 6340 KLTH0G19008p XP_002555853.1 1641134 R 559295 CDS KLTH0G19030g 255719147 8294149 1644503..1647160 1 NC_013083.1 weakly similar to uniprot|P43560 Saccharomyces cerevisiae YFL042C Due to a sequence change (deletion of G at 46151) YFL043C is now part of YFL042C.; KLTH0G19030p 1647160 8294149 KLTH0G19030g Lachancea thermotolerans CBS 6340 KLTH0G19030p XP_002555854.1 1644503 D 559295 CDS KLTH0G19052g 255719149 8294150 complement(1647196..1647780) 1 NC_013083.1 similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C Hypothetical ORF; KLTH0G19052p 1647780 8294150 KLTH0G19052g Lachancea thermotolerans CBS 6340 KLTH0G19052p XP_002555855.1 1647196 R 559295 CDS KLTH0G19074g 255719151 8294151 1648296..1649237 1 NC_013083.1 similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C YOD1 Yeast OTU Deubiquitinating enzyme 1; KLTH0G19074p 1649237 8294151 KLTH0G19074g Lachancea thermotolerans CBS 6340 KLTH0G19074p XP_002555856.1 1648296 D 559295 CDS KLTH0G19096g 255719153 8294152 complement(1649335..1649814) 1 NC_013083.1 highly similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; KLTH0G19096p 1649814 8294152 KLTH0G19096g Lachancea thermotolerans CBS 6340 KLTH0G19096p XP_002555857.1 1649335 R 559295 CDS KLTH0G19118g 255719155 8294153 1650244..1650906 1 NC_013083.1 highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W; KLTH0G19118p 1650906 8294153 KLTH0G19118g Lachancea thermotolerans CBS 6340 KLTH0G19118p XP_002555858.1 1650244 D 559295 CDS KLTH0G19140g 255719157 8294154 1651268..1652035 1 NC_013083.1 highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 involved in synthesis of GDP- mannose and dolichol-phosphate-mannose required for protein assembly in endoplasmic reticulum phosphomannomutase; KLTH0G19140p 1652035 8294154 KLTH0G19140g Lachancea thermotolerans CBS 6340 KLTH0G19140p XP_002555859.1 1651268 D 559295 CDS KLTH0G19162g 255719159 8294155 complement(1652121..1652744) 1 NC_013083.1 highly similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 The authentic non-tagged protein was localized to the mitochondria; KLTH0G19162p 1652744 8294155 KLTH0G19162g Lachancea thermotolerans CBS 6340 KLTH0G19162p XP_002555860.1 1652121 R 559295 CDS KLTH0G19184g 255719161 8294156 1652908..1654677 1 NC_013083.1 similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 The authentic non-tagged protein was localized to the mitochondria; KLTH0G19184p 1654677 8294156 KLTH0G19184g Lachancea thermotolerans CBS 6340 KLTH0G19184p XP_002555861.1 1652908 D 559295 CDS KLTH0G19206g 255719163 8294157 complement(join(1654713..1655429,1655489..1655491)) 1 NC_013083.1 similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor) localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; KLTH0G19206p 1655491 8294157 KLTH0G19206g Lachancea thermotolerans CBS 6340 KLTH0G19206p XP_002555862.1 1654713 R 559295 CDS KLTH0G19228g 255719165 8294158 1657189..1658076 1 NC_013083.1 weakly similar to uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 P40 inhibitor of Cdc28p-Clb5p protein kinase complex; KLTH0G19228p 1658076 8294158 KLTH0G19228g Lachancea thermotolerans CBS 6340 KLTH0G19228p XP_002555863.1 1657189 D 559295 CDS KLTH0G19250g 255719167 8294159 complement(1658141..1660312) 1 NC_013083.1 similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; KLTH0G19250p 1660312 8294159 KLTH0G19250g Lachancea thermotolerans CBS 6340 KLTH0G19250p XP_002555864.1 1658141 R 559295 CDS KLTH0G19272g 255719169 8294160 1660418..1660795 1 NC_013083.1 conserved hypothetical protein; KLTH0G19272p 1660795 8294160 KLTH0G19272g Lachancea thermotolerans CBS 6340 KLTH0G19272p XP_002555865.1 1660418 D 559295 CDS KLTH0G19294g 255719171 8294161 1661294..1662577 1 NC_013083.1 similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport; KLTH0G19294p 1662577 8294161 KLTH0G19294g Lachancea thermotolerans CBS 6340 KLTH0G19294p XP_002555866.1 1661294 D 559295 CDS KLTH0G19316g 255719173 8294162 complement(1662674..1664230) 1 NC_013083.1 similar to uniprot|P43554 Saccharomyces cerevisiae YFL049W Hypothetical ORF; KLTH0G19316p 1664230 8294162 KLTH0G19316g Lachancea thermotolerans CBS 6340 KLTH0G19316p XP_002555867.1 1662674 R 559295 CDS KLTH0G19338g 255719175 8294163 complement(1665123..1666520) 1 NC_013083.1 highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase catalyzes the final step in the arginine biosynthesis pathway; KLTH0G19338p 1666520 8294163 KLTH0G19338g Lachancea thermotolerans CBS 6340 KLTH0G19338p XP_002555868.1 1665123 R 559295 CDS KLTH0G19360g 255719177 8294164 1667351..1668259 1 NC_013083.1 similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Hypothetical ORF; KLTH0G19360p 1668259 8294164 KLTH0G19360g Lachancea thermotolerans CBS 6340 KLTH0G19360p XP_002555869.1 1667351 D 559295 CDS KLTH0G19382g 255719179 8294165 1669540..1671345 1 NC_013083.1 conserved hypothetical protein; KLTH0G19382p 1671345 8294165 KLTH0G19382g Lachancea thermotolerans CBS 6340 KLTH0G19382p XP_002555870.1 1669540 D 559295 CDS KLTH0G19404g 255719181 8294166 1672150..1673691 1 NC_013083.1 weakly similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor; KLTH0G19404p 1673691 8294166 KLTH0G19404g Lachancea thermotolerans CBS 6340 KLTH0G19404p XP_002555871.1 1672150 D 559295 CDS KLTH0G19426g 255719183 8294167 complement(1673739..1675781) 1 NC_013083.1 conserved hypothetical protein; KLTH0G19426p 1675781 8294167 KLTH0G19426g Lachancea thermotolerans CBS 6340 KLTH0G19426p XP_002555872.1 1673739 R 559295 CDS KLTH0G19448g 255719185 8294168 1676895..1681355 1 NC_013083.1 similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 ATP binding cassette (ABC) transporter of the plasma membrane general stress response factor implicated in cellular detoxification target of Pdr1p Pdr3p and Pdr8p transcription regulators promoter contains a PDR responsive element; KLTH0G19448p 1681355 8294168 KLTH0G19448g Lachancea thermotolerans CBS 6340 KLTH0G19448p XP_002555873.1 1676895 D 559295 CDS KLTH0G19470g 255719187 8294169 complement(1681657..1683414) 1 NC_013083.1 highly similar to uniprot|P53341 Saccharomyces cerevisiae YGR292W MAL12 Maltase (alpha-D-glucosidase) inducible protein involved in maltose catabolism encoded in the MAL1 complex locus; KLTH0G19470p 1683414 8294169 KLTH0G19470g Lachancea thermotolerans CBS 6340 KLTH0G19470p XP_002555874.1 1681657 R 559295 CDS KLTH0G19492g 255719189 8294170 1684750..1685064 1 NC_013083.1 no similarity; KLTH0G19492p 1685064 8294170 KLTH0G19492g Lachancea thermotolerans CBS 6340 KLTH0G19492p XP_002555875.1 1684750 D 559295 CDS KLTH0G19536g 255719191 8294172 1688018..1689001 1 NC_013083.1 weakly similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; KLTH0G19536p 1689001 8294172 KLTH0G19536g Lachancea thermotolerans CBS 6340 KLTH0G19536p XP_002555876.1 1688018 D 559295 CDS KLTH0G19558g 255719193 8294173 1691076..1692050 1 NC_013083.1 weakly similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; KLTH0G19558p 1692050 8294173 KLTH0G19558g Lachancea thermotolerans CBS 6340 KLTH0G19558p XP_002555877.1 1691076 D 559295 CDS KLTH0G19580g 255719195 8294174 1693206..1694351 1 NC_013083.1 weakly similar to uniprot|P38723 Saccharomyces cerevisiae YHL048W COS8 Nuclear membrane protein, member of a family of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; KLTH0G19580p 1694351 8294174 KLTH0G19580g Lachancea thermotolerans CBS 6340 KLTH0G19580p XP_002555878.1 1693206 D 559295 CDS KLTH0G19602g 255719197 8294175 1695851..1696954 1 NC_013083.1 conserved hypothetical protein; KLTH0G19602p 1696954 8294175 KLTH0G19602g Lachancea thermotolerans CBS 6340 KLTH0G19602p XP_002555879.1 1695851 D 559295 CDS KLTH0G19624g 255719199 8294176 complement(1697587..1698993) 1 NC_013083.1 similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF; KLTH0G19624p 1698993 8294176 KLTH0G19624g Lachancea thermotolerans CBS 6340 KLTH0G19624p XP_002555880.1 1697587 R 559295 CDS KLTH0G19646g 255719201 8294177 complement(1699421..1700560) 1 NC_013083.1 conserved hypothetical protein; KLTH0G19646p 1700560 8294177 KLTH0G19646g Lachancea thermotolerans CBS 6340 KLTH0G19646p XP_002555881.1 1699421 R 559295 CDS KLTH0G19668g 255719203 8294178 1702771..1704297 1 NC_013083.1 weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease; KLTH0G19668p 1704297 8294178 KLTH0G19668g Lachancea thermotolerans CBS 6340 KLTH0G19668p XP_002555882.1 1702771 D 559295 CDS KLTH0G19690g 255719205 8294179 complement(1704559..1706325) 1 NC_013083.1 weakly similar to uniprot|P53059 Saccharomyces cerevisiae YGL257C MNT2 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans; KLTH0G19690p 1706325 8294179 KLTH0G19690g Lachancea thermotolerans CBS 6340 KLTH0G19690p XP_002555883.1 1704559 R 559295 CDS KLTH0G19734g 255719207 8294181 1710007..1710249 1 NC_013083.1 no similarity; KLTH0G19734p 1710249 8294181 KLTH0G19734g Lachancea thermotolerans CBS 6340 KLTH0G19734p XP_002555884.1 1710007 D 559295 CDS KLTH0G19756g 255719209 8294182 complement(1713024..1713935) 1 NC_013083.1 similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Hypothetical ORF; KLTH0G19756p 1713935 8294182 KLTH0G19756g Lachancea thermotolerans CBS 6340 KLTH0G19756p XP_002555885.1 1713024 R 559295 CDS KLTH0G19800g 255719211 8294184 1715316..1717265 1 NC_013083.1 similar to uniprot|Q08347 Saccharomyces cerevisiae YOL164W BDS1 Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources; KLTH0G19800p 1717265 8294184 KLTH0G19800g Lachancea thermotolerans CBS 6340 KLTH0G19800p XP_002555886.1 1715316 D 559295 CDS KLTH0H00132g 255719214 8294196 complement(3987..5309) 1 NC_013084.1 highly similar to uniprot|P40896 Saccharomyces cerevisiae YJL213W Hypothetical ORF; KLTH0H00132p 5309 8294196 KLTH0H00132g Lachancea thermotolerans CBS 6340 KLTH0H00132p XP_002555887.1 3987 R 559295 CDS KLTH0H00154g 255719216 8294197 complement(6702..8039) 1 NC_013084.1 conserved hypothetical protein; KLTH0H00154p 8039 8294197 KLTH0H00154g Lachancea thermotolerans CBS 6340 KLTH0H00154p XP_002555888.1 6702 R 559295 CDS KLTH0H00198g 255719218 8294199 17248..17763 1 NC_013084.1 conserved hypothetical protein; KLTH0H00198p 17763 8294199 KLTH0H00198g Lachancea thermotolerans CBS 6340 KLTH0H00198p XP_002555889.1 17248 D 559295 CDS KLTH0H00220g 255719220 8294200 complement(18972..19883) 1 NC_013084.1 similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family; KLTH0H00220p 19883 8294200 KLTH0H00220g Lachancea thermotolerans CBS 6340 KLTH0H00220p XP_002555890.1 18972 R 559295 CDS KLTH0H00264g 255719222 8294202 complement(23047..23715) 1 NC_013084.1 similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria; KLTH0H00264p 23715 8294202 KLTH0H00264g Lachancea thermotolerans CBS 6340 KLTH0H00264p XP_002555891.1 23047 R 559295 CDS KLTH0H00286g 255719224 8294203 complement(24401..26059) 1 NC_013084.1 some similarities with uniprot|P53857 Saccharomyces cerevisiae YNL234W similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p; KLTH0H00286p 26059 8294203 KLTH0H00286g Lachancea thermotolerans CBS 6340 KLTH0H00286p XP_002555892.1 24401 R 559295 CDS KLTH0H00308g 255719226 8294204 28695..30227 1 NC_013084.1 weakly similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor; KLTH0H00308p 30227 8294204 KLTH0H00308g Lachancea thermotolerans CBS 6340 KLTH0H00308p XP_002555893.1 28695 D 559295 CDS KLTH0H00330g 255719228 8294205 31537..36237 1 NC_013084.1 similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy; KLTH0H00330p 36237 8294205 KLTH0H00330g Lachancea thermotolerans CBS 6340 KLTH0H00330p XP_002555894.1 31537 D 559295 CDS KLTH0H00352g 255719230 8294206 36466..39633 1 NC_013084.1 similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis; KLTH0H00352p 39633 8294206 KLTH0H00352g Lachancea thermotolerans CBS 6340 KLTH0H00352p XP_002555895.1 36466 D 559295 CDS KLTH0H00374g 255719232 8294207 complement(39762..41297) 1 NC_013084.1 highly similar to uniprot|P11412 YNL241C Saccharomyces cerevisiae ZWF1 Glucose-6-phosphate dehydrogenase; KLTH0H00374p 41297 8294207 KLTH0H00374g Lachancea thermotolerans CBS 6340 KLTH0H00374p XP_002555896.1 39762 R 559295 CDS KLTH0H00396g 255719234 8294208 complement(43400..44791) 1 NC_013084.1 similar to uniprot|P23503 YNL240C Saccharomyces cerevisiae NAR1 Nuclear architecture related protein component of the cytosolic iron-sulfur (FeS) protein assembly machinery; KLTH0H00396p 44791 8294208 KLTH0H00396g Lachancea thermotolerans CBS 6340 KLTH0H00396p XP_002555897.1 43400 R 559295 CDS KLTH0H00418g 255719236 8294209 46022..48457 1 NC_013084.1 similar to uniprot|P13134 YNL238W Saccharomyces cerevisiae KEX2 Subtilisin-like protease (proprotein convertase); KLTH0H00418p 48457 8294209 KLTH0H00418g Lachancea thermotolerans CBS 6340 KLTH0H00418p XP_002555898.1 46022 D 559295 CDS KLTH0H00440g 255719238 8294210 48723..50072 1 NC_013084.1 similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W YTP1; KLTH0H00440p 50072 8294210 KLTH0H00440g Lachancea thermotolerans CBS 6340 KLTH0H00440p XP_002555899.1 48723 D 559295 CDS KLTH0H00462g 255719240 8294211 51279..54104 1 NC_013084.1 similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription; KLTH0H00462p 54104 8294211 KLTH0H00462g Lachancea thermotolerans CBS 6340 KLTH0H00462p XP_002555900.1 51279 D 559295 CDS KLTH0H00506g 255719242 8294213 complement(join(56283..57332,57377..57424)) 1 NC_013084.1 conserved hypothetical protein; KLTH0H00506p 57424 8294213 KLTH0H00506g Lachancea thermotolerans CBS 6340 KLTH0H00506p XP_002555901.1 56283 R 559295 CDS KLTH0H00528g 255719244 8294214 57753..58538 1 NC_013084.1 highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta; KLTH0H00528p 58538 8294214 KLTH0H00528g Lachancea thermotolerans CBS 6340 KLTH0H00528p XP_002555902.1 57753 D 559295 CDS KLTH0H00550g 255719246 8294215 complement(58659..59945) 1 NC_013084.1 highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase acetylates lysine 14 on histone H3 catalytic subunit of the ADA and SAGA histone acetyltransferase complexes founding member of the Gcn5p-related N-acetyltransferase superfamily; KLTH0H00550p 59945 8294215 KLTH0H00550g Lachancea thermotolerans CBS 6340 KLTH0H00550p XP_002555903.1 58659 R 559295 CDS KLTH0H00572g 255719248 8294216 complement(60065..61960) 1 NC_013084.1 similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes; KLTH0H00572p 61960 8294216 KLTH0H00572g Lachancea thermotolerans CBS 6340 KLTH0H00572p XP_002555904.1 60065 R 559295 CDS KLTH0H00594g 255719250 8294217 complement(62142..63680) 1 NC_013084.1 highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; KLTH0H00594p 63680 8294217 KLTH0H00594g Lachancea thermotolerans CBS 6340 KLTH0H00594p XP_002555905.1 62142 R 559295 CDS KLTH0H00616g 255719252 8294218 complement(63837..64415) 1 NC_013084.1 similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability; KLTH0H00616p 64415 8294218 KLTH0H00616g Lachancea thermotolerans CBS 6340 KLTH0H00616p XP_002555906.1 63837 R 559295 CDS KLTH0H00638g 255719254 8294219 complement(64621..65922) 1 NC_013084.1 highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit; KLTH0H00638p 65922 8294219 KLTH0H00638g Lachancea thermotolerans CBS 6340 KLTH0H00638p XP_002555907.1 64621 R 559295 CDS KLTH0H00660g 255719256 8294220 complement(67991..69601) 1 NC_013084.1 similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly; KLTH0H00660p 69601 8294220 KLTH0H00660g Lachancea thermotolerans CBS 6340 KLTH0H00660p XP_002555908.1 67991 R 559295 CDS KLTH0H00682g 255719258 8294221 complement(69803..70579) 1 NC_013084.1 some similarities with uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation; KLTH0H00682p 70579 8294221 KLTH0H00682g Lachancea thermotolerans CBS 6340 KLTH0H00682p XP_002555909.1 69803 R 559295 CDS KLTH0H00704g 255719260 8294222 70712..72577 1 NC_013084.1 similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition; KLTH0H00704p 72577 8294222 KLTH0H00704g Lachancea thermotolerans CBS 6340 KLTH0H00704p XP_002555910.1 70712 D 559295 CDS KLTH0H00726g 255719262 8294223 72819..80063 1 NC_013084.1 highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing; KLTH0H00726p 80063 8294223 KLTH0H00726g Lachancea thermotolerans CBS 6340 KLTH0H00726p XP_002555911.1 72819 D 559295 CDS KLTH0H00748g 255719264 8294224 complement(81177..81479) 1 NC_013084.1 no similarity; KLTH0H00748p 81479 8294224 KLTH0H00748g Lachancea thermotolerans CBS 6340 KLTH0H00748p XP_002555912.1 81177 R 559295 CDS KLTH0H00770g 255719266 8294225 81755..86374 1 NC_013084.1 similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate; KLTH0H00770p 86374 8294225 KLTH0H00770g Lachancea thermotolerans CBS 6340 KLTH0H00770p XP_002555913.1 81755 D 559295 CDS KLTH0H00792g 255719268 8294226 88079..90586 1 NC_013084.1 some similarities with uniprot|P53316 Saccharomyces cerevisiae YGR250C Hypothetical ORF; KLTH0H00792p 90586 8294226 KLTH0H00792g Lachancea thermotolerans CBS 6340 KLTH0H00792p XP_002555914.1 88079 D 559295 CDS KLTH0H00814g 255719270 8294227 complement(90962..92134) 1 NC_013084.1 some similarities with uniprot|P53050 Saccharomyces cerevisiae YGR249W MGA1 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants; KLTH0H00814p 92134 8294227 KLTH0H00814g Lachancea thermotolerans CBS 6340 KLTH0H00814p XP_002555915.1 90962 R 559295 CDS KLTH0H00836g 255719272 8294228 complement(92994..94133) 1 NC_013084.1 similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W SOL3 Glucose-6-phosphate dehydrogenase weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p; KLTH0H00836p 94133 8294228 KLTH0H00836g Lachancea thermotolerans CBS 6340 KLTH0H00836p XP_002555916.1 92994 R 559295 CDS KLTH0H00858g 255719274 8294229 join(94956..95027,95139..95480) 1 NC_013084.1 similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43; KLTH0H00858p 95480 8294229 KLTH0H00858g Lachancea thermotolerans CBS 6340 KLTH0H00858p XP_002555917.1 94956 D 559295 CDS KLTH0H00880g 255719276 8294230 complement(95812..97068) 1 NC_013084.1 highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; KLTH0H00880p 97068 8294230 KLTH0H00880g Lachancea thermotolerans CBS 6340 KLTH0H00880p XP_002555918.1 95812 R 559295 CDS KLTH0H00902g 255719278 8294231 complement(97752..99944) 1 NC_013084.1 similar to uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin; KLTH0H00902p 99944 8294231 KLTH0H00902g Lachancea thermotolerans CBS 6340 KLTH0H00902p XP_002555919.1 97752 R 559295 CDS KLTH0H00924g 255719280 8294232 complement(100199..101914) 1 NC_013084.1 similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB; KLTH0H00924p 101914 8294232 KLTH0H00924g Lachancea thermotolerans CBS 6340 KLTH0H00924p XP_002555920.1 100199 R 559295 CDS KLTH0H00946g 255719282 8294233 102427..103074 1 NC_013084.1 similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression; KLTH0H00946p 103074 8294233 KLTH0H00946g Lachancea thermotolerans CBS 6340 KLTH0H00946p XP_002555921.1 102427 D 559295 CDS KLTH0H00968g 255719284 8294234 103482..105353 1 NC_013084.1 similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma- aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1 UGA2 UGA4) zinc- finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type localized to the nucleus; KLTH0H00968p 105353 8294234 KLTH0H00968g Lachancea thermotolerans CBS 6340 KLTH0H00968p XP_002555922.1 103482 D 559295 CDS KLTH0H00990g 255719286 8294235 complement(105471..105998) 1 NC_013084.1 similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF; KLTH0H00990p 105998 8294235 KLTH0H00990g Lachancea thermotolerans CBS 6340 KLTH0H00990p XP_002555923.1 105471 R 559295 CDS KLTH0H01012g 255719288 8294236 complement(106313..106945) 1 NC_013084.1 no similarity; KLTH0H01012p 106945 8294236 KLTH0H01012g Lachancea thermotolerans CBS 6340 KLTH0H01012p XP_002555924.1 106313 R 559295 CDS KLTH0H01034g 255719290 8294237 complement(107338..108687) 1 NC_013084.1 similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; KLTH0H01034p 108687 8294237 KLTH0H01034g Lachancea thermotolerans CBS 6340 KLTH0H01034p XP_002555925.1 107338 R 559295 CDS KLTH0H01122g 255719292 8294239 113798..115537 1 NC_013084.1 similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1; KLTH0H01122p 115537 8294239 KLTH0H01122g Lachancea thermotolerans CBS 6340 KLTH0H01122p XP_002555926.1 113798 D 559295 CDS KLTH0H01144g 255719294 8294240 complement(115683..116168) 1 NC_013084.1 weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 Protein of unknown function; KLTH0H01144p 116168 8294240 KLTH0H01144g Lachancea thermotolerans CBS 6340 KLTH0H01144p XP_002555927.1 115683 R 559295 CDS KLTH0H01166g 255719296 8294241 116579..118102 1 NC_013084.1 highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA; KLTH0H01166p 118102 8294241 KLTH0H01166g Lachancea thermotolerans CBS 6340 KLTH0H01166p XP_002555928.1 116579 D 559295 CDS KLTH0H01188g 255719298 8294242 complement(join(118222..119019,119088..119093)) 1 NC_013084.1 similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C Hypothetical ORF; KLTH0H01188p 119093 8294242 KLTH0H01188g Lachancea thermotolerans CBS 6340 KLTH0H01188p XP_002555929.1 118222 R 559295 CDS KLTH0H01210g 255719300 8294243 119243..119584 1 NC_013084.1 similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene; KLTH0H01210p 119584 8294243 KLTH0H01210g Lachancea thermotolerans CBS 6340 KLTH0H01210p XP_002555930.1 119243 D 559295 CDS KLTH0H01232g 255719302 8294244 complement(119673..120446) 1 NC_013084.1 similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53; KLTH0H01232p 120446 8294244 KLTH0H01232g Lachancea thermotolerans CBS 6340 KLTH0H01232p XP_002555931.1 119673 R 559295 CDS KLTH0H01254g 255719304 8294245 121076..122221 1 NC_013084.1 highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase); KLTH0H01254p 122221 8294245 KLTH0H01254g Lachancea thermotolerans CBS 6340 KLTH0H01254p XP_002555932.1 121076 D 559295 CDS KLTH0H01276g 255719306 8294246 complement(122337..124010) 1 NC_013084.1 some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1; KLTH0H01276p 124010 8294246 KLTH0H01276g Lachancea thermotolerans CBS 6340 KLTH0H01276p XP_002555933.1 122337 R 559295 CDS KLTH0H01298g 255719308 8294247 complement(124206..124850) 1 NC_013084.1 similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response; KLTH0H01298p 124850 8294247 KLTH0H01298g Lachancea thermotolerans CBS 6340 KLTH0H01298p XP_002555934.1 124206 R 559295 CDS KLTH0H01320g 255719310 8294248 125017..125589 1 NC_013084.1 highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor; KLTH0H01320p 125589 8294248 KLTH0H01320g Lachancea thermotolerans CBS 6340 KLTH0H01320p XP_002555935.1 125017 D 559295 CDS KLTH0H01342g 255719312 8294249 complement(125673..126941) 1 NC_013084.1 similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA; KLTH0H01342p 126941 8294249 KLTH0H01342g Lachancea thermotolerans CBS 6340 KLTH0H01342p XP_002555936.1 125673 R 559295 CDS KLTH0H01364g 255719314 8294250 127939..128232 1 NC_013084.1 conserved hypothetical protein; KLTH0H01364p 128232 8294250 KLTH0H01364g Lachancea thermotolerans CBS 6340 KLTH0H01364p XP_002555937.1 127939 D 559295 CDS KLTH0H01386g 255719316 8294251 complement(128402..129325) 1 NC_013084.1 similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme; KLTH0H01386p 129325 8294251 KLTH0H01386g Lachancea thermotolerans CBS 6340 KLTH0H01386p XP_002555938.1 128402 R 559295 CDS KLTH0H01408g 255719318 8294252 complement(129752..131923) 1 NC_013084.1 similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination; KLTH0H01408p 131923 8294252 KLTH0H01408g Lachancea thermotolerans CBS 6340 KLTH0H01408p XP_002555939.1 129752 R 559295 CDS KLTH0H01430g 255719320 8294253 132738..134246 1 NC_013084.1 some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1; KLTH0H01430p 134246 8294253 KLTH0H01430g Lachancea thermotolerans CBS 6340 KLTH0H01430p XP_002555940.1 132738 D 559295 CDS KLTH0H01452g 255719322 8294254 complement(134324..134584) 1 NC_013084.1 weakly similar to uniprot|Q3E829 Saccharomyces cerevisiae YDL160c-a; KLTH0H01452p 134584 8294254 KLTH0H01452g Lachancea thermotolerans CBS 6340 KLTH0H01452p XP_002555941.1 134324 R 559295 CDS KLTH0H01474g 255719324 8294255 complement(134657..135802) 1 NC_013084.1 conserved hypothetical protein; KLTH0H01474p 135802 8294255 KLTH0H01474g Lachancea thermotolerans CBS 6340 KLTH0H01474p XP_002555942.1 134657 R 559295 CDS KLTH0H01496g 255719326 8294256 135932..138172 1 NC_013084.1 weakly similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; KLTH0H01496p 138172 8294256 KLTH0H01496g Lachancea thermotolerans CBS 6340 KLTH0H01496p XP_002555943.1 135932 D 559295 CDS KLTH0H01518g 255719328 8294257 138469..139353 1 NC_013084.1 highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles; KLTH0H01518p 139353 8294257 KLTH0H01518g Lachancea thermotolerans CBS 6340 KLTH0H01518p XP_002555944.1 138469 D 559295 CDS KLTH0H01540g 255719330 8294258 complement(139430..140347) 1 NC_013084.1 similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides; KLTH0H01540p 140347 8294258 KLTH0H01540g Lachancea thermotolerans CBS 6340 KLTH0H01540p XP_002555945.1 139430 R 559295 CDS KLTH0H01562g 255719332 8294259 complement(140915..142390) 1 NC_013084.1 similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation; KLTH0H01562p 142390 8294259 KLTH0H01562g Lachancea thermotolerans CBS 6340 KLTH0H01562p XP_002555946.1 140915 R 559295 CDS KLTH0H01584g 255719334 8294260 143065..144453 1 NC_013084.1 similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway; KLTH0H01584p 144453 8294260 KLTH0H01584g Lachancea thermotolerans CBS 6340 KLTH0H01584p XP_002555947.1 143065 D 559295 CDS KLTH0H01606g 255719336 8294261 complement(144510..144836) 1 NC_013084.1 similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF; KLTH0H01606p 144836 8294261 KLTH0H01606g Lachancea thermotolerans CBS 6340 KLTH0H01606p XP_002555948.1 144510 R 559295 CDS KLTH0H01628g 255719338 8294262 144953..146488 1 NC_013084.1 similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF; KLTH0H01628p 146488 8294262 KLTH0H01628g Lachancea thermotolerans CBS 6340 KLTH0H01628p XP_002555949.1 144953 D 559295 CDS KLTH0H01650g 255719340 8294263 complement(146708..147451) 1 NC_013084.1 similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF; KLTH0H01650p 147451 8294263 KLTH0H01650g Lachancea thermotolerans CBS 6340 KLTH0H01650p XP_002555950.1 146708 R 559295 CDS KLTH0H01672g 255719342 8294264 complement(148024..150129) 1 NC_013084.1 conserved hypothetical protein; KLTH0H01672p 150129 8294264 KLTH0H01672g Lachancea thermotolerans CBS 6340 KLTH0H01672p XP_002555951.1 148024 R 559295 CDS KLTH0H01694g 255719344 8294265 151103..152431 1 NC_013084.1 similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3; KLTH0H01694p 152431 8294265 KLTH0H01694g Lachancea thermotolerans CBS 6340 KLTH0H01694p XP_002555952.1 151103 D 559295 CDS KLTH0H01716g 255719346 8294266 complement(152669..154462) 1 NC_013084.1 similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre- 18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing; KLTH0H01716p 154462 8294266 KLTH0H01716g Lachancea thermotolerans CBS 6340 KLTH0H01716p XP_002555953.1 152669 R 559295 CDS KLTH0H01738g 255719348 8294267 154705..155961 1 NC_013084.1 similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53; KLTH0H01738p 155961 8294267 KLTH0H01738g Lachancea thermotolerans CBS 6340 KLTH0H01738p XP_002555954.1 154705 D 559295 CDS KLTH0H01760g 255719350 8294268 156245..159010 1 NC_013084.1 similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre- autophagosomal structure and other cytosolic punctate structures not found in autophagosomes; KLTH0H01760p 159010 8294268 KLTH0H01760g Lachancea thermotolerans CBS 6340 KLTH0H01760p XP_002555955.1 156245 D 559295 CDS KLTH0H01782g 255719352 8294269 complement(159110..161554) 1 NC_013084.1 similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre- 18S rRNA; KLTH0H01782p 161554 8294269 KLTH0H01782g Lachancea thermotolerans CBS 6340 KLTH0H01782p XP_002555956.1 159110 R 559295 CDS KLTH0H01804g 255719354 8294270 161820..163145 1 NC_013084.1 highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid; KLTH0H01804p 163145 8294270 KLTH0H01804g Lachancea thermotolerans CBS 6340 KLTH0H01804p XP_002555957.1 161820 D 559295 CDS KLTH0H01826g 255719356 8294271 complement(163221..163757) 1 NC_013084.1 weakly similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF; KLTH0H01826p 163757 8294271 KLTH0H01826g Lachancea thermotolerans CBS 6340 KLTH0H01826p XP_002555958.1 163221 R 559295 CDS KLTH0H01848g 255719358 8294272 164062..165513 1 NC_013084.1 similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck; KLTH0H01848p 165513 8294272 KLTH0H01848g Lachancea thermotolerans CBS 6340 KLTH0H01848p XP_002555959.1 164062 D 559295 CDS KLTH0H01870g 255719360 8294273 complement(165566..166972) 1 NC_013084.1 similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; KLTH0H01870p 166972 8294273 KLTH0H01870g Lachancea thermotolerans CBS 6340 KLTH0H01870p XP_002555960.1 165566 R 559295 CDS KLTH0H01892g 255719362 8294274 complement(167262..170891) 1 NC_013084.1 highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway; KLTH0H01892p 170891 8294274 KLTH0H01892g Lachancea thermotolerans CBS 6340 KLTH0H01892p XP_002555961.1 167262 R 559295 CDS KLTH0H01914g 255719364 8294275 complement(171281..172708) 1 NC_013084.1 similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C CRR1 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; KLTH0H01914p 172708 8294275 KLTH0H01914g Lachancea thermotolerans CBS 6340 KLTH0H01914p XP_002555962.1 171281 R 559295 CDS KLTH0H01936g 255719366 8294276 173705..175792 1 NC_013084.1 similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels; KLTH0H01936p 175792 8294276 KLTH0H01936g Lachancea thermotolerans CBS 6340 KLTH0H01936p XP_002555963.1 173705 D 559295 CDS KLTH0H01958g 255719368 8294277 complement(175829..176929) 1 NC_013084.1 similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123; KLTH0H01958p 176929 8294277 KLTH0H01958g Lachancea thermotolerans CBS 6340 KLTH0H01958p XP_002555964.1 175829 R 559295 CDS KLTH0H01980g 255719370 8294278 177187..178773 1 NC_013084.1 highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo; KLTH0H01980p 178773 8294278 KLTH0H01980g Lachancea thermotolerans CBS 6340 KLTH0H01980p XP_002555965.1 177187 D 559295 CDS KLTH0H02002g 255719372 8294279 complement(179383..180156) 1 NC_013084.1 similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function; KLTH0H02002p 180156 8294279 KLTH0H02002g Lachancea thermotolerans CBS 6340 KLTH0H02002p XP_002555966.1 179383 R 559295 CDS KLTH0H02024g 255719374 8294280 180518..182566 1 NC_013084.1 similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase; KLTH0H02024p 182566 8294280 KLTH0H02024g Lachancea thermotolerans CBS 6340 KLTH0H02024p XP_002555967.1 180518 D 559295 CDS KLTH0H02046g 255719376 8294281 complement(182788..188010) 1 NC_013084.1 highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C; KLTH0H02046p 188010 8294281 KLTH0H02046g Lachancea thermotolerans CBS 6340 KLTH0H02046p XP_002555968.1 182788 R 559295 CDS KLTH0H02068g 255719378 8294282 complement(188834..189946) 1 NC_013084.1 similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity; KLTH0H02068p 189946 8294282 KLTH0H02068g Lachancea thermotolerans CBS 6340 KLTH0H02068p XP_002555969.1 188834 R 559295 CDS KLTH0H02090g 255719380 8294283 complement(190131..190814) 1 NC_013084.1 some similarities with uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation; KLTH0H02090p 190814 8294283 KLTH0H02090g Lachancea thermotolerans CBS 6340 KLTH0H02090p XP_002555970.1 190131 R 559295 CDS KLTH0H02112g 255719382 8294284 complement(190872..191120) 1 NC_013084.1 similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF; KLTH0H02112p 191120 8294284 KLTH0H02112g Lachancea thermotolerans CBS 6340 KLTH0H02112p XP_002555971.1 190872 R 559295 CDS KLTH0H02134g 255719384 8294285 191540..195439 1 NC_013084.1 similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles; KLTH0H02134p 195439 8294285 KLTH0H02134g Lachancea thermotolerans CBS 6340 KLTH0H02134p XP_002555972.1 191540 D 559295 CDS KLTH0H02156g 255719386 8294286 195794..197944 1 NC_013084.1 similar to uniprot|P10870 Saccharomyces cerevisiae YDL194W SNF3 glucose sensor; KLTH0H02156p 197944 8294286 KLTH0H02156g Lachancea thermotolerans CBS 6340 KLTH0H02156p XP_002555973.1 195794 D 559295 CDS KLTH0H02178g 255719388 8294287 198169..199221 1 NC_013084.1 similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1; KLTH0H02178p 199221 8294287 KLTH0H02178g Lachancea thermotolerans CBS 6340 KLTH0H02178p XP_002555974.1 198169 D 559295 CDS KLTH0H02200g 255719390 8294288 199831..200376 1 NC_013084.1 highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W ARF1 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf2p; KLTH0H02200p 200376 8294288 KLTH0H02200g Lachancea thermotolerans CBS 6340 KLTH0H02200p XP_002555975.1 199831 D 559295 CDS KLTH0H02222g 255719392 8294289 201281..201826 1 NC_013084.1 highly similar to uniprot|P19146 Saccharomyces cerevisiae YDL137W ARF2 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf1p; KLTH0H02222p 201826 8294289 KLTH0H02222g Lachancea thermotolerans CBS 6340 KLTH0H02222p XP_002555976.1 201281 D 559295 CDS KLTH0H02244g 255719394 8294290 join(203853..203855,204273..204632) 1 NC_013084.1 highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit; KLTH0H02244p 204632 8294290 KLTH0H02244g Lachancea thermotolerans CBS 6340 KLTH0H02244p XP_002555977.1 203853 D 559295 CDS KLTH0H02266g 255719396 8294291 complement(204726..207569) 1 NC_013084.1 similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex; KLTH0H02266p 207569 8294291 KLTH0H02266g Lachancea thermotolerans CBS 6340 KLTH0H02266p XP_002555978.1 204726 R 559295 CDS KLTH0H02288g 255719398 8294292 207932..208915 1 NC_013084.1 some similarities with uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain; KLTH0H02288p 208915 8294292 KLTH0H02288g Lachancea thermotolerans CBS 6340 KLTH0H02288p XP_002555979.1 207932 D 559295 CDS KLTH0H02310g 255719400 8294293 complement(209037..209639) 1 NC_013084.1 highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor; KLTH0H02310p 209639 8294293 KLTH0H02310g Lachancea thermotolerans CBS 6340 KLTH0H02310p XP_002555980.1 209037 R 559295 CDS KLTH0H02332g 255719402 8294294 209858..210418 1 NC_013084.1 conserved hypothetical protein; KLTH0H02332p 210418 8294294 KLTH0H02332g Lachancea thermotolerans CBS 6340 KLTH0H02332p XP_002555981.1 209858 D 559295 CDS KLTH0H02354g 255719404 8294295 complement(210576..211646) 1 NC_013084.1 highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C PPH21 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph22p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis; KLTH0H02354p 211646 8294295 KLTH0H02354g Lachancea thermotolerans CBS 6340 KLTH0H02354p XP_002555982.1 210576 R 559295 CDS KLTH0H02376g 255719406 8294296 212454..213176 1 NC_013084.1 some similarities with uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF; KLTH0H02376p 213176 8294296 KLTH0H02376g Lachancea thermotolerans CBS 6340 KLTH0H02376p XP_002555983.1 212454 D 559295 CDS KLTH0H02398g 255719408 8294297 214364..216220 1 NC_013084.1 uniprot|Q8J0L0 VMA1 Putative vacuolar membrane H- ATPase; KLTH0H02398p 216220 8294297 KLTH0H02398g Lachancea thermotolerans CBS 6340 KLTH0H02398p XP_002555984.1 214364 D 559295 CDS KLTH0H02420g 255719410 8294298 complement(217847..218743) 1 NC_013084.1 similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF; KLTH0H02420p 218743 8294298 KLTH0H02420g Lachancea thermotolerans CBS 6340 KLTH0H02420p XP_002555985.1 217847 R 559295 CDS KLTH0H02442g 255719412 8294299 219117..220556 1 NC_013084.1 similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W; KLTH0H02442p 220556 8294299 KLTH0H02442g Lachancea thermotolerans CBS 6340 KLTH0H02442p XP_002555986.1 219117 D 559295 CDS KLTH0H02464g 255719414 8294300 220805..223228 1 NC_013084.1 similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; KLTH0H02464p 223228 8294300 KLTH0H02464g Lachancea thermotolerans CBS 6340 KLTH0H02464p XP_002555987.1 220805 D 559295 CDS KLTH0H02486g 255719416 8294301 223641..224963 1 NC_013084.1 highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase; KLTH0H02486p 224963 8294301 KLTH0H02486g Lachancea thermotolerans CBS 6340 KLTH0H02486p XP_002555988.1 223641 D 559295 CDS KLTH0H02508g 255719418 8294302 complement(225069..225998) 1 NC_013084.1 conserved hypothetical protein; KLTH0H02508p 225998 8294302 KLTH0H02508g Lachancea thermotolerans CBS 6340 KLTH0H02508p XP_002555989.1 225069 R 559295 CDS KLTH0H02530g 255719420 8294303 226577..226873 1 NC_013084.1 some similarities with uniprot|P01097 Saccharomyces cerevisiae YDL181W; KLTH0H02530p 226873 8294303 KLTH0H02530g Lachancea thermotolerans CBS 6340 KLTH0H02530p XP_002555990.1 226577 D 559295 CDS KLTH0H02552g 255719422 8294304 join(227237..227276,227330..227523) 1 NC_013084.1 similar to uniprot|Q3E7A9 Saccharomyces cerevisiae YMR194C-B; KLTH0H02552p 227523 8294304 KLTH0H02552g Lachancea thermotolerans CBS 6340 KLTH0H02552p XP_002555991.1 227237 D 559295 CDS KLTH0H02574g 255719424 8294305 complement(227944..228507) 1 NC_013084.1 conserved hypothetical protein; KLTH0H02574p 228507 8294305 KLTH0H02574g Lachancea thermotolerans CBS 6340 KLTH0H02574p XP_002555992.1 227944 R 559295 CDS KLTH0H02596g 255719426 8294306 complement(join(228747..229033,229410..229425)) 1 NC_013084.1 highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit; KLTH0H02596p 229425 8294306 KLTH0H02596g Lachancea thermotolerans CBS 6340 KLTH0H02596p XP_002555993.1 228747 R 559295 CDS KLTH0H02618g 255719428 8294307 complement(229993..230814) 1 NC_013084.1 similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit; KLTH0H02618p 230814 8294307 KLTH0H02618g Lachancea thermotolerans CBS 6340 KLTH0H02618p XP_002555994.1 229993 R 559295 CDS KLTH0H02640g 255719430 8294308 complement(230918..233359) 1 NC_013084.1 weakly similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p involved in ER to Golgi trafficking interacts with the yeast amphiphysins Rvs161p and Rvs167p; KLTH0H02640p 233359 8294308 KLTH0H02640g Lachancea thermotolerans CBS 6340 KLTH0H02640p XP_002555995.1 230918 R 559295 CDS KLTH0H02662g 255719432 8294309 complement(233610..234716) 1 NC_013084.1 weakly similar to uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources; KLTH0H02662p 234716 8294309 KLTH0H02662g Lachancea thermotolerans CBS 6340 KLTH0H02662p XP_002555996.1 233610 R 559295 CDS KLTH0H02684g 255719434 8294310 complement(235527..237776) 1 NC_013084.1 weakly similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose repressed by Gal80p and activated by Gal3p; KLTH0H02684p 237776 8294310 KLTH0H02684g Lachancea thermotolerans CBS 6340 KLTH0H02684p XP_002555997.1 235527 R 559295 CDS KLTH0H02706g 255719436 8294311 238367..242578 1 NC_013084.1 similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity; KLTH0H02706p 242578 8294311 KLTH0H02706g Lachancea thermotolerans CBS 6340 KLTH0H02706p XP_002555998.1 238367 D 559295 CDS KLTH0H02728g 255719438 8294312 complement(242682..244436) 1 NC_013084.1 similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide; KLTH0H02728p 244436 8294312 KLTH0H02728g Lachancea thermotolerans CBS 6340 KLTH0H02728p XP_002555999.1 242682 R 559295 CDS KLTH0H02750g 255719440 8294313 complement(245136..248195) 1 NC_013084.1 highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm; KLTH0H02750p 248195 8294313 KLTH0H02750g Lachancea thermotolerans CBS 6340 KLTH0H02750p XP_002556000.1 245136 R 559295 CDS KLTH0H02772g 255719442 8294314 complement(248747..250009) 1 NC_013084.1 similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF; KLTH0H02772p 250009 8294314 KLTH0H02772g Lachancea thermotolerans CBS 6340 KLTH0H02772p XP_002556001.1 248747 R 559295 CDS KLTH0H02794g 255719444 8294315 250363..251052 1 NC_013084.1 similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit; KLTH0H02794p 251052 8294315 KLTH0H02794g Lachancea thermotolerans CBS 6340 KLTH0H02794p XP_002556002.1 250363 D 559295 CDS KLTH0H02816g 255719446 8294316 complement(join(251152..251795,251876..252086)) 1 NC_013084.1 similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p; KLTH0H02816p 252086 8294316 KLTH0H02816g Lachancea thermotolerans CBS 6340 KLTH0H02816p XP_002556003.1 251152 R 559295 CDS KLTH0H02838g 255719448 8294317 253022..254389 1 NC_013084.1 similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF; KLTH0H02838p 254389 8294317 KLTH0H02838g Lachancea thermotolerans CBS 6340 KLTH0H02838p XP_002556004.1 253022 D 559295 CDS KLTH0H02860g 255719450 8294318 complement(254461..255453) 1 NC_013084.1 similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP- galactose transport to the Golgi lumen; KLTH0H02860p 255453 8294318 KLTH0H02860g Lachancea thermotolerans CBS 6340 KLTH0H02860p XP_002556005.1 254461 R 559295 CDS KLTH0H02882g 255719452 8294319 255761..257518 1 NC_013084.1 similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; KLTH0H02882p 257518 8294319 KLTH0H02882g Lachancea thermotolerans CBS 6340 KLTH0H02882p XP_002556006.1 255761 D 559295 CDS KLTH0H02904g 255719454 8294320 257821..259587 1 NC_013084.1 conserved hypothetical protein; KLTH0H02904p 259587 8294320 KLTH0H02904g Lachancea thermotolerans CBS 6340 KLTH0H02904p XP_002556007.1 257821 D 559295 CDS KLTH0H02926g 255719456 8294321 complement(259800..264359) 1 NC_013084.1 similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p; KLTH0H02926p 264359 8294321 KLTH0H02926g Lachancea thermotolerans CBS 6340 KLTH0H02926p XP_002556008.1 259800 R 559295 CDS KLTH0H02948g 255719458 8294322 complement(join(264580..265364,265424..265505)) 1 NC_013084.1 weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl; KLTH0H02948p 265505 8294322 KLTH0H02948g Lachancea thermotolerans CBS 6340 KLTH0H02948p XP_002556009.1 264580 R 559295 CDS KLTH0H02970g 255719460 8294323 complement(265781..267895) 1 NC_013084.1 highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family; KLTH0H02970p 267895 8294323 KLTH0H02970g Lachancea thermotolerans CBS 6340 KLTH0H02970p XP_002556010.1 265781 R 559295 CDS KLTH0H02992g 255719462 8294324 complement(268190..271054) 1 NC_013084.1 similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability; KLTH0H02992p 271054 8294324 KLTH0H02992g Lachancea thermotolerans CBS 6340 KLTH0H02992p XP_002556011.1 268190 R 559295 CDS KLTH0H03014g 255719464 8294325 271566..272159 1 NC_013084.1 similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1; KLTH0H03014p 272159 8294325 KLTH0H03014g Lachancea thermotolerans CBS 6340 KLTH0H03014p XP_002556012.1 271566 D 559295 CDS KLTH0H03036g 255719466 8294326 272447..273298 1 NC_013084.1 similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon; KLTH0H03036p 273298 8294326 KLTH0H03036g Lachancea thermotolerans CBS 6340 KLTH0H03036p XP_002556013.1 272447 D 559295 CDS KLTH0H03058g 255719468 8294327 complement(273404..273898) 1 NC_013084.1 weakly similar to uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF; KLTH0H03058p 273898 8294327 KLTH0H03058g Lachancea thermotolerans CBS 6340 KLTH0H03058p XP_002556014.1 273404 R 559295 CDS KLTH0H03080g 255719470 8294328 complement(274038..275078) 1 NC_013084.1 similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Hypothetical ORF; KLTH0H03080p 275078 8294328 KLTH0H03080g Lachancea thermotolerans CBS 6340 KLTH0H03080p XP_002556015.1 274038 R 559295 CDS KLTH0H03102g 255719472 8294329 275767..277179 1 NC_013084.1 highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue; KLTH0H03102p 277179 8294329 KLTH0H03102g Lachancea thermotolerans CBS 6340 KLTH0H03102p XP_002556016.1 275767 D 559295 CDS KLTH0H03124g 255719474 8294330 complement(277395..277889) 1 NC_013084.1 highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c'; KLTH0H03124p 277889 8294330 KLTH0H03124g Lachancea thermotolerans CBS 6340 KLTH0H03124p XP_002556017.1 277395 R 559295 CDS KLTH0H03146g 255719476 8294331 278598..279245 1 NC_013084.1 similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation; KLTH0H03146p 279245 8294331 KLTH0H03146g Lachancea thermotolerans CBS 6340 KLTH0H03146p XP_002556018.1 278598 D 559295 CDS KLTH0H03168g 255719478 8294332 279697..280563 1 NC_013084.1 highly similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W SSO1 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE; KLTH0H03168p 280563 8294332 KLTH0H03168g Lachancea thermotolerans CBS 6340 KLTH0H03168p XP_002556019.1 279697 D 559295 CDS KLTH0H03190g 255719480 8294333 281852..287524 1 NC_013084.1 highly similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; KLTH0H03190p 287524 8294333 KLTH0H03190g Lachancea thermotolerans CBS 6340 KLTH0H03190p XP_002556020.1 281852 D 559295 CDS KLTH0H03212g 255719482 8294334 288203..288628 1 NC_013084.1 some similarities with uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF; KLTH0H03212p 288628 8294334 KLTH0H03212g Lachancea thermotolerans CBS 6340 KLTH0H03212p XP_002556021.1 288203 D 559295 CDS KLTH0H03234g 255719484 8294335 288945..290384 1 NC_013084.1 highly similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate-terminated RNA mRNA capping enzyme beta subunit RNA 5'-triphosphatase; KLTH0H03234p 290384 8294335 KLTH0H03234g Lachancea thermotolerans CBS 6340 KLTH0H03234p XP_002556022.1 288945 D 559295 CDS KLTH0H03256g 255719486 8294336 complement(290490..291488) 1 NC_013084.1 similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum; KLTH0H03256p 291488 8294336 KLTH0H03256g Lachancea thermotolerans CBS 6340 KLTH0H03256p XP_002556023.1 290490 R 559295 CDS KLTH0H03278g 255719488 8294337 complement(292114..294105) 1 NC_013084.1 weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2- HHT2 but not required at the other histone loci functionally related to Spt10p; KLTH0H03278p 294105 8294337 KLTH0H03278g Lachancea thermotolerans CBS 6340 KLTH0H03278p XP_002556024.1 292114 R 559295 CDS KLTH0H03300g 255719490 8294338 295271..298801 1 NC_013084.1 similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU]; KLTH0H03300p 298801 8294338 KLTH0H03300g Lachancea thermotolerans CBS 6340 KLTH0H03300p XP_002556025.1 295271 D 559295 CDS KLTH0H03322g 255719492 8294339 complement(298885..299754) 1 NC_013084.1 similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF; KLTH0H03322p 299754 8294339 KLTH0H03322g Lachancea thermotolerans CBS 6340 KLTH0H03322p XP_002556026.1 298885 R 559295 CDS KLTH0H03366g 255719494 8294340 303157..303603 1 NC_013084.1 similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF; KLTH0H03366p 303603 8294340 KLTH0H03366g Lachancea thermotolerans CBS 6340 KLTH0H03366p XP_002556027.1 303157 D 559295 CDS KLTH0H03388g 255719496 8294341 complement(303810..305315) 1 NC_013084.1 similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p; KLTH0H03388p 305315 8294341 KLTH0H03388g Lachancea thermotolerans CBS 6340 KLTH0H03388p XP_002556028.1 303810 R 559295 CDS KLTH0H03410g 255719498 8294342 complement(305531..309943) 1 NC_013084.1 similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks; KLTH0H03410p 309943 8294342 KLTH0H03410g Lachancea thermotolerans CBS 6340 KLTH0H03410p XP_002556029.1 305531 R 559295 CDS KLTH0H03432g 255719500 8294343 complement(310426..310851) 1 NC_013084.1 conserved hypothetical protein; KLTH0H03432p 310851 8294343 KLTH0H03432g Lachancea thermotolerans CBS 6340 KLTH0H03432p XP_002556030.1 310426 R 559295 CDS KLTH0H03454g 255719502 8294344 311863..312234 1 NC_013084.1 conserved hypothetical protein; KLTH0H03454p 312234 8294344 KLTH0H03454g Lachancea thermotolerans CBS 6340 KLTH0H03454p XP_002556031.1 311863 D 559295 CDS KLTH0H03476g 255719504 8294345 complement(312577..314055) 1 NC_013084.1 weakly similar to uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein expression is increased in response to heat-shock stress or treatments that produce DNA lesions; KLTH0H03476p 314055 8294345 KLTH0H03476g Lachancea thermotolerans CBS 6340 KLTH0H03476p XP_002556032.1 312577 R 559295 CDS KLTH0H03498g 255719506 8294346 complement(315060..317054) 1 NC_013084.1 weakly similar to uniprot|Q03213 Saccharomyces cerevisiae YMR172W; KLTH0H03498p 317054 8294346 KLTH0H03498g Lachancea thermotolerans CBS 6340 KLTH0H03498p XP_002556033.1 315060 R 559295 CDS KLTH0H03520g 255719508 8294347 317431..319425 1 NC_013084.1 similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria; KLTH0H03520p 319425 8294347 KLTH0H03520g Lachancea thermotolerans CBS 6340 KLTH0H03520p XP_002556034.1 317431 D 559295 CDS KLTH0H03542g 255719510 8294348 320024..322993 1 NC_013084.1 weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria; KLTH0H03542p 322993 8294348 KLTH0H03542g Lachancea thermotolerans CBS 6340 KLTH0H03542p XP_002556035.1 320024 D 559295 CDS KLTH0H03564g 255719512 8294349 323465..325921 1 NC_013084.1 similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation; KLTH0H03564p 325921 8294349 KLTH0H03564g Lachancea thermotolerans CBS 6340 KLTH0H03564p XP_002556036.1 323465 D 559295 CDS KLTH0H03586g 255719514 8294350 complement(326294..327442) 1 NC_013084.1 weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C Hypothetical ORF; KLTH0H03586p 327442 8294350 KLTH0H03586g Lachancea thermotolerans CBS 6340 KLTH0H03586p XP_002556037.1 326294 R 559295 CDS KLTH0H03608g 255719516 8294351 join(327747..327764,327941..330550) 1 NC_013084.1 similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer; KLTH0H03608p 330550 8294351 KLTH0H03608g Lachancea thermotolerans CBS 6340 KLTH0H03608p XP_002556038.1 327747 D 559295 CDS KLTH0H03630g 255719518 8294352 complement(330705..331637) 1 NC_013084.1 similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ; KLTH0H03630p 331637 8294352 KLTH0H03630g Lachancea thermotolerans CBS 6340 KLTH0H03630p XP_002556039.1 330705 R 559295 CDS KLTH0H03652g 255719520 8294353 332634..333287 1 NC_013084.1 highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit; KLTH0H03652p 333287 8294353 KLTH0H03652g Lachancea thermotolerans CBS 6340 KLTH0H03652p XP_002556040.1 332634 D 559295 CDS KLTH0H03674g 255719522 8294354 333755..335209 1 NC_013084.1 weakly similar to uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate; KLTH0H03674p 335209 8294354 KLTH0H03674g Lachancea thermotolerans CBS 6340 KLTH0H03674p XP_002556041.1 333755 D 559295 CDS KLTH0H03696g 255719524 8294355 join(335581..335602,335689..336233) 1 NC_013084.1 highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport; KLTH0H03696p 336233 8294355 KLTH0H03696g Lachancea thermotolerans CBS 6340 KLTH0H03696p XP_002556042.1 335581 D 559295 CDS KLTH0H03718g 255719526 8294356 complement(336334..339840) 1 NC_013084.1 similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p; KLTH0H03718p 339840 8294356 KLTH0H03718g Lachancea thermotolerans CBS 6340 KLTH0H03718p XP_002556043.1 336334 R 559295 CDS KLTH0H03740g 255719528 8294357 340497..343829 1 NC_013084.1 similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a- specific genes repression of early meiotic genes during mitotic growth and repression of INO1; KLTH0H03740p 343829 8294357 KLTH0H03740g Lachancea thermotolerans CBS 6340 KLTH0H03740p XP_002556044.1 340497 D 559295 CDS KLTH0H03762g 255719530 8294358 344164..345174 1 NC_013084.1 similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex; KLTH0H03762p 345174 8294358 KLTH0H03762g Lachancea thermotolerans CBS 6340 KLTH0H03762p XP_002556045.1 344164 D 559295 CDS KLTH0H03784g 255719532 8294359 complement(345221..346837) 1 NC_013084.1 similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities; KLTH0H03784p 346837 8294359 KLTH0H03784g Lachancea thermotolerans CBS 6340 KLTH0H03784p XP_002556046.1 345221 R 559295 CDS KLTH0H03806g 255719534 8294360 347049..347747 1 NC_013084.1 weakly similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein; KLTH0H03806p 347747 8294360 KLTH0H03806g Lachancea thermotolerans CBS 6340 KLTH0H03806p XP_002556047.1 347049 D 559295 CDS KLTH0H03828g 255719536 8294361 complement(348388..352851) 1 NC_013084.1 similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2; KLTH0H03828p 352851 8294361 KLTH0H03828g Lachancea thermotolerans CBS 6340 KLTH0H03828p XP_002556048.1 348388 R 559295 CDS KLTH0H03850g 255719538 8294362 352972..354378 1 NC_013084.1 similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit; KLTH0H03850p 354378 8294362 KLTH0H03850g Lachancea thermotolerans CBS 6340 KLTH0H03850p XP_002556049.1 352972 D 559295 CDS KLTH0H03872g 255719540 8294363 complement(354482..355798) 1 NC_013084.1 similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit; KLTH0H03872p 355798 8294363 KLTH0H03872g Lachancea thermotolerans CBS 6340 KLTH0H03872p XP_002556050.1 354482 R 559295 CDS KLTH0H03894g 255719542 8294364 complement(join(356036..357524,357593..357744)) 1 NC_013084.1 similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis; intranuclear protein which exhibits a nucleotide-specific intron- dependent tRNA pseudouridine synthase activity; KLTH0H03894p 357744 8294364 KLTH0H03894g Lachancea thermotolerans CBS 6340 KLTH0H03894p XP_002556051.1 356036 R 559295 CDS KLTH0H03916g 255719544 8294365 359019..359564 1 NC_013084.1 highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis; KLTH0H03916p 359564 8294365 KLTH0H03916g Lachancea thermotolerans CBS 6340 KLTH0H03916p XP_002556052.1 359019 D 559295 CDS KLTH0H03938g 255719546 8294366 complement(359677..361488) 1 NC_013084.1 similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane; KLTH0H03938p 361488 8294366 KLTH0H03938g Lachancea thermotolerans CBS 6340 KLTH0H03938p XP_002556053.1 359677 R 559295 CDS KLTH0H03960g 255719548 8294367 361653..363323 1 NC_013084.1 similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function; KLTH0H03960p 363323 8294367 KLTH0H03960g Lachancea thermotolerans CBS 6340 KLTH0H03960p XP_002556054.1 361653 D 559295 CDS KLTH0H03982g 255719550 8294368 complement(363432..364628) 1 NC_013084.1 similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate; KLTH0H03982p 364628 8294368 KLTH0H03982g Lachancea thermotolerans CBS 6340 KLTH0H03982p XP_002556055.1 363432 R 559295 CDS KLTH0H04004g 255719552 8294369 365097..366854 1 NC_013084.1 similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W Hypothetical ORF; KLTH0H04004p 366854 8294369 KLTH0H04004g Lachancea thermotolerans CBS 6340 KLTH0H04004p XP_002556056.1 365097 D 559295 CDS KLTH0H04026g 255719554 8294370 367008..369362 1 NC_013084.1 similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W Hypothetical ORF; KLTH0H04026p 369362 8294370 KLTH0H04026g Lachancea thermotolerans CBS 6340 KLTH0H04026p XP_002556057.1 367008 D 559295 CDS KLTH0H04048g 255719556 8294371 complement(369508..370734) 1 NC_013084.1 conserved hypothetical protein; KLTH0H04048p 370734 8294371 KLTH0H04048g Lachancea thermotolerans CBS 6340 KLTH0H04048p XP_002556058.1 369508 R 559295 CDS KLTH0H04070g 255719558 8294372 370823..372388 1 NC_013084.1 similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2- PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation; KLTH0H04070p 372388 8294372 KLTH0H04070g Lachancea thermotolerans CBS 6340 KLTH0H04070p XP_002556059.1 370823 D 559295 CDS KLTH0H04092g 255719560 8294373 complement(372453..374153) 1 NC_013084.1 some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex; KLTH0H04092p 374153 8294373 KLTH0H04092g Lachancea thermotolerans CBS 6340 KLTH0H04092p XP_002556060.1 372453 R 559295 CDS KLTH0H04114g 255719562 8294374 complement(374596..375561) 1 NC_013084.1 similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function; KLTH0H04114p 375561 8294374 KLTH0H04114g Lachancea thermotolerans CBS 6340 KLTH0H04114p XP_002556061.1 374596 R 559295 CDS KLTH0H04136g 255719564 8294375 complement(375792..376874) 1 NC_013084.1 similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes; KLTH0H04136p 376874 8294375 KLTH0H04136g Lachancea thermotolerans CBS 6340 KLTH0H04136p XP_002556062.1 375792 R 559295 CDS KLTH0H04158g 255719566 8294376 378344..379798 1 NC_013084.1 similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta); KLTH0H04158p 379798 8294376 KLTH0H04158g Lachancea thermotolerans CBS 6340 KLTH0H04158p XP_002556063.1 378344 D 559295 CDS KLTH0H04180g 255719568 8294377 381111..382172 1 NC_013084.1 highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit; KLTH0H04180p 382172 8294377 KLTH0H04180g Lachancea thermotolerans CBS 6340 KLTH0H04180p XP_002556064.1 381111 D 559295 CDS KLTH0H04202g 255719570 8294378 complement(382391..382903) 1 NC_013084.1 similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid; KLTH0H04202p 382903 8294378 KLTH0H04202g Lachancea thermotolerans CBS 6340 KLTH0H04202p XP_002556065.1 382391 R 559295 CDS KLTH0H04224g 255719572 8294379 383808..384176 1 NC_013084.1 highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site; KLTH0H04224p 384176 8294379 KLTH0H04224g Lachancea thermotolerans CBS 6340 KLTH0H04224p XP_002556066.1 383808 D 559295 CDS KLTH0H04246g 255719574 8294380 complement(384406..385968) 1 NC_013084.1 similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; KLTH0H04246p 385968 8294380 KLTH0H04246g Lachancea thermotolerans CBS 6340 KLTH0H04246p XP_002556067.1 384406 R 559295 CDS KLTH0H04268g 255719576 8294381 complement(386347..387456) 1 NC_013084.1 conserved hypothetical protein; KLTH0H04268p 387456 8294381 KLTH0H04268g Lachancea thermotolerans CBS 6340 KLTH0H04268p XP_002556068.1 386347 R 559295 CDS KLTH0H04290g 255719578 8294382 complement(387890..389599) 1 NC_013084.1 similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements; KLTH0H04290p 389599 8294382 KLTH0H04290g Lachancea thermotolerans CBS 6340 KLTH0H04290p XP_002556069.1 387890 R 559295 CDS KLTH0H04312g 255719580 8294383 390454..391614 1 NC_013084.1 weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p; KLTH0H04312p 391614 8294383 KLTH0H04312g Lachancea thermotolerans CBS 6340 KLTH0H04312p XP_002556070.1 390454 D 559295 CDS KLTH0H04334g 255719582 8294384 complement(391678..392478) 1 NC_013084.1 similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF; KLTH0H04334p 392478 8294384 KLTH0H04334g Lachancea thermotolerans CBS 6340 KLTH0H04334p XP_002556071.1 391678 R 559295 CDS KLTH0H04356g 255719584 8294385 393543..394142 1 NC_013084.1 conserved hypothetical protein; KLTH0H04356p 394142 8294385 KLTH0H04356g Lachancea thermotolerans CBS 6340 KLTH0H04356p XP_002556072.1 393543 D 559295 CDS KLTH0H04400g 255719586 8294943 join(395550..395560,395924..396017,396294..396923) 1 NC_013084.1 highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit; KLTH0H04400p 396923 8294943 KLTH0H04400g Lachancea thermotolerans CBS 6340 KLTH0H04400p XP_002556073.1 395550 D 559295 CDS KLTH0H04444g 255719588 8294942 397467..399065 1 NC_013084.1 similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co- regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo- inositol; KLTH0H04444p 399065 8294942 KLTH0H04444g Lachancea thermotolerans CBS 6340 KLTH0H04444p XP_002556074.1 397467 D 559295 CDS KLTH0H04466g 255719590 8294388 399689..401350 1 NC_013084.1 similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; KLTH0H04466p 401350 8294388 KLTH0H04466g Lachancea thermotolerans CBS 6340 KLTH0H04466p XP_002556075.1 399689 D 559295 CDS KLTH0H04488g 255719592 8294389 401548..403272 1 NC_013084.1 conserved hypothetical protein; KLTH0H04488p 403272 8294389 KLTH0H04488g Lachancea thermotolerans CBS 6340 KLTH0H04488p XP_002556076.1 401548 D 559295 CDS KLTH0H04510g 255719594 8294390 403524..404264 1 NC_013084.1 similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide; KLTH0H04510p 404264 8294390 KLTH0H04510g Lachancea thermotolerans CBS 6340 KLTH0H04510p XP_002556077.1 403524 D 559295 CDS KLTH0H04532g 255719596 8294391 complement(404281..404928) 1 NC_013084.1 similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF; KLTH0H04532p 404928 8294391 KLTH0H04532g Lachancea thermotolerans CBS 6340 KLTH0H04532p XP_002556078.1 404281 R 559295 CDS KLTH0H04554g 255719598 8294392 405046..407877 1 NC_013084.1 similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP- 3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex; KLTH0H04554p 407877 8294392 KLTH0H04554g Lachancea thermotolerans CBS 6340 KLTH0H04554p XP_002556079.1 405046 D 559295 CDS KLTH0H04576g 255719600 8294393 408053..409687 1 NC_013084.1 similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA- like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate; KLTH0H04576p 409687 8294393 KLTH0H04576g Lachancea thermotolerans CBS 6340 KLTH0H04576p XP_002556080.1 408053 D 559295 CDS KLTH0H04598g 255719602 8294394 411070..412059 1 NC_013084.1 similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly; KLTH0H04598p 412059 8294394 KLTH0H04598g Lachancea thermotolerans CBS 6340 KLTH0H04598p XP_002556081.1 411070 D 559295 CDS KLTH0H04620g 255719604 8294395 complement(412730..413935) 1 NC_013084.1 some similarities with uniprot|P53156 Saccharomyces cerevisiae YGL081W Hypothetical ORF; KLTH0H04620p 413935 8294395 KLTH0H04620g Lachancea thermotolerans CBS 6340 KLTH0H04620p XP_002556082.1 412730 R 559295 CDS KLTH0H04642g 255719606 8294396 complement(414364..415497) 1 NC_013084.1 similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs; KLTH0H04642p 415497 8294396 KLTH0H04642g Lachancea thermotolerans CBS 6340 KLTH0H04642p XP_002556083.1 414364 R 559295 CDS KLTH0H04664g 255719608 8294397 complement(415939..418380) 1 NC_013084.1 similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p; KLTH0H04664p 418380 8294397 KLTH0H04664g Lachancea thermotolerans CBS 6340 KLTH0H04664p XP_002556084.1 415939 R 559295 CDS KLTH0H04686g 255719610 8294398 complement(419384..421726) 1 NC_013084.1 similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant; KLTH0H04686p 421726 8294398 KLTH0H04686g Lachancea thermotolerans CBS 6340 KLTH0H04686p XP_002556085.1 419384 R 559295 CDS KLTH0H04730g 255719612 8294400 422975..424768 1 NC_013084.1 similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C GUP1 Multimembrane-spanning protein and similar to uniprot|Q08929 Saccharomyces cerevisiae YPL189W GUP2; KLTH0H04730p 424768 8294400 KLTH0H04730g Lachancea thermotolerans CBS 6340 KLTH0H04730p XP_002556086.1 422975 D 559295 CDS KLTH0H04752g 255719614 8294401 complement(424818..425618) 1 NC_013084.1 similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF; KLTH0H04752p 425618 8294401 KLTH0H04752g Lachancea thermotolerans CBS 6340 KLTH0H04752p XP_002556087.1 424818 R 559295 CDS KLTH0H04774g 255719616 8294402 complement(426645..428621) 1 NC_013084.1 similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle- assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p; KLTH0H04774p 428621 8294402 KLTH0H04774g Lachancea thermotolerans CBS 6340 KLTH0H04774p XP_002556088.1 426645 R 559295 CDS KLTH0H04796g 255719618 8294403 join(428760..428770,428834..429239) 1 NC_013084.1 highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Protein involved in error-free postreplication DNA repair forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity cooperates with chromatin-associated RING finger proteins Rad18p and Rad5p; KLTH0H04796p 429239 8294403 KLTH0H04796g Lachancea thermotolerans CBS 6340 KLTH0H04796p XP_002556089.1 428760 D 559295 CDS KLTH0H04818g 255719620 8294404 429493..430752 1 NC_013084.1 highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD( ) with lower specificity required for the response to oxidative stress; KLTH0H04818p 430752 8294404 KLTH0H04818g Lachancea thermotolerans CBS 6340 KLTH0H04818p XP_002556090.1 429493 D 559295 CDS KLTH0H04840g 255719622 8294405 complement(431325..432656) 1 NC_013084.1 similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes; KLTH0H04840p 432656 8294405 KLTH0H04840g Lachancea thermotolerans CBS 6340 KLTH0H04840p XP_002556091.1 431325 R 559295 CDS KLTH0H04862g 255719624 8294406 434269..434814 1 NC_013084.1 similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor; KLTH0H04862p 434814 8294406 KLTH0H04862g Lachancea thermotolerans CBS 6340 KLTH0H04862p XP_002556092.1 434269 D 559295 CDS KLTH0H04884g 255719626 8294407 complement(435202..435855) 1 NC_013084.1 some similarities with uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein of unknown function; KLTH0H04884p 435855 8294407 KLTH0H04884g Lachancea thermotolerans CBS 6340 KLTH0H04884p XP_002556093.1 435202 R 559295 CDS KLTH0H04906g 255719628 8294408 complement(436720..438429) 1 NC_013084.1 similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF; KLTH0H04906p 438429 8294408 KLTH0H04906g Lachancea thermotolerans CBS 6340 KLTH0H04906p XP_002556094.1 436720 R 559295 CDS KLTH0H04928g 255719630 8294409 complement(439113..440429) 1 NC_013084.1 weakly similar to uniprot|P53150 Saccharomyces cerevisiae YGL090W LIF1 Protein involved in DNA double- strand break repair physically interacts with DNA ligase 4 (Lig4p) homologous to mammalian XRCC4 protein; KLTH0H04928p 440429 8294409 KLTH0H04928g Lachancea thermotolerans CBS 6340 KLTH0H04928p XP_002556095.1 439113 R 559295 CDS KLTH0H04950g 255719632 8294410 440614..441585 1 NC_013084.1 highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta; KLTH0H04950p 441585 8294410 KLTH0H04950g Lachancea thermotolerans CBS 6340 KLTH0H04950p XP_002556096.1 440614 D 559295 CDS KLTH0H04972g 255719634 8294411 complement(441659..445576) 1 NC_013084.1 similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex; KLTH0H04972p 445576 8294411 KLTH0H04972g Lachancea thermotolerans CBS 6340 KLTH0H04972p XP_002556097.1 441659 R 559295 CDS KLTH0H04994g 255719636 8294412 complement(445934..448648) 1 NC_013084.1 weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105; KLTH0H04994p 448648 8294412 KLTH0H04994g Lachancea thermotolerans CBS 6340 KLTH0H04994p XP_002556098.1 445934 R 559295 CDS KLTH0H05016g 255719638 8294413 join(448816..448965,449041..449112) 1 NC_013084.1 some similarities with uniprot|O14464 Saccharomyces cerevisiae YPL183W-A; KLTH0H05016p 449112 8294413 KLTH0H05016g Lachancea thermotolerans CBS 6340 KLTH0H05016p XP_002556099.1 448816 D 559295 CDS KLTH0H05038g 255719640 8294414 complement(449230..452217) 1 NC_013084.1 similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF; KLTH0H05038p 452217 8294414 KLTH0H05038g Lachancea thermotolerans CBS 6340 KLTH0H05038p XP_002556100.1 449230 R 559295 CDS KLTH0H05060g 255719642 8294415 452490..455876 1 NC_013084.1 similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; KLTH0H05060p 455876 8294415 KLTH0H05060g Lachancea thermotolerans CBS 6340 KLTH0H05060p XP_002556101.1 452490 D 559295 CDS KLTH0H05082g 255719644 8294416 complement(456119..458281) 1 NC_013084.1 weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One; KLTH0H05082p 458281 8294416 KLTH0H05082g Lachancea thermotolerans CBS 6340 KLTH0H05082p XP_002556102.1 456119 R 559295 CDS KLTH0H05104g 255719646 8294417 458594..460333 1 NC_013084.1 similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p; KLTH0H05104p 460333 8294417 KLTH0H05104g Lachancea thermotolerans CBS 6340 KLTH0H05104p XP_002556103.1 458594 D 559295 CDS KLTH0H05126g 255719648 8294418 complement(460360..461550) 1 NC_013084.1 similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain; KLTH0H05126p 461550 8294418 KLTH0H05126g Lachancea thermotolerans CBS 6340 KLTH0H05126p XP_002556104.1 460360 R 559295 CDS KLTH0H05148g 255719650 8294419 462699..464246 1 NC_013084.1 similar to uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase null mutation enhances efficiency of translational suppressors; KLTH0H05148p 464246 8294419 KLTH0H05148g Lachancea thermotolerans CBS 6340 KLTH0H05148p XP_002556105.1 462699 D 559295 CDS KLTH0H05214g 255719652 8294421 465108..465710 1 NC_013084.1 highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif; KLTH0H05214p 465710 8294421 KLTH0H05214g Lachancea thermotolerans CBS 6340 KLTH0H05214p XP_002556106.1 465108 D 559295 CDS KLTH0H05236g 255719654 8294422 complement(465998..466702) 1 NC_013084.1 some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin- dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription; KLTH0H05236p 466702 8294422 KLTH0H05236g Lachancea thermotolerans CBS 6340 KLTH0H05236p XP_002556107.1 465998 R 559295 CDS KLTH0H05258g 255719656 8294423 467504..469522 1 NC_013084.1 weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W Hypothetical ORF; KLTH0H05258p 469522 8294423 KLTH0H05258g Lachancea thermotolerans CBS 6340 KLTH0H05258p XP_002556108.1 467504 D 559295 CDS KLTH0H05280g 255719658 8294424 complement(469755..471596) 1 NC_013084.1 similar to uniprot|P38156 Saccharomyces cerevisiae YBR298C MAL31 Maltose permease high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL3 complex locus member of the 12 transmembrane domain superfamily of sugar transporters functional in genomic reference strain S288C; KLTH0H05280p 471596 8294424 KLTH0H05280g Lachancea thermotolerans CBS 6340 KLTH0H05280p XP_002556109.1 469755 R 559295 CDS KLTH0H05324g 255719660 8294425 472845..474605 1 NC_013084.1 similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C Hypothetical ORF; KLTH0H05324p 474605 8294425 KLTH0H05324g Lachancea thermotolerans CBS 6340 KLTH0H05324p XP_002556110.1 472845 D 559295 CDS KLTH0H05346g 255719662 8294426 475454..476554 1 NC_013084.1 highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase; KLTH0H05346p 476554 8294426 KLTH0H05346g Lachancea thermotolerans CBS 6340 KLTH0H05346p XP_002556111.1 475454 D 559295 CDS KLTH0H05368g 255719664 8294427 477523..479175 1 NC_013084.1 highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor; KLTH0H05368p 479175 8294427 KLTH0H05368g Lachancea thermotolerans CBS 6340 KLTH0H05368p XP_002556112.1 477523 D 559295 CDS KLTH0H05390g 255719666 8294428 complement(479388..480833) 1 NC_013084.1 similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p; KLTH0H05390p 480833 8294428 KLTH0H05390g Lachancea thermotolerans CBS 6340 KLTH0H05390p XP_002556113.1 479388 R 559295 CDS KLTH0H05412g 255719668 8294429 481190..482041 1 NC_013084.1 conserved hypothetical protein; KLTH0H05412p 482041 8294429 KLTH0H05412g Lachancea thermotolerans CBS 6340 KLTH0H05412p XP_002556114.1 481190 D 559295 CDS KLTH0H05434g 255719670 8294430 482267..483655 1 NC_013084.1 similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus; KLTH0H05434p 483655 8294430 KLTH0H05434g Lachancea thermotolerans CBS 6340 KLTH0H05434p XP_002556115.1 482267 D 559295 CDS KLTH0H05456g 255719672 8294431 484160..485866 1 NC_013084.1 similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane; KLTH0H05456p 485866 8294431 KLTH0H05456g Lachancea thermotolerans CBS 6340 KLTH0H05456p XP_002556116.1 484160 D 559295 CDS KLTH0H05478g 255719674 8294432 complement(485876..486706) 1 NC_013084.1 similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability; KLTH0H05478p 486706 8294432 KLTH0H05478g Lachancea thermotolerans CBS 6340 KLTH0H05478p XP_002556117.1 485876 R 559295 CDS KLTH0H05500g 255719676 8294433 487381..489102 1 NC_013084.1 similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions; KLTH0H05500p 489102 8294433 KLTH0H05500g Lachancea thermotolerans CBS 6340 KLTH0H05500p XP_002556118.1 487381 D 559295 CDS KLTH0H05522g 255719678 8294434 complement(489992..491911) 1 NC_013084.1 highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm; KLTH0H05522p 491911 8294434 KLTH0H05522g Lachancea thermotolerans CBS 6340 KLTH0H05522p XP_002556119.1 489992 R 559295 CDS KLTH0H05544g 255719680 8294435 complement(492106..493374) 1 NC_013084.1 similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF; KLTH0H05544p 493374 8294435 KLTH0H05544g Lachancea thermotolerans CBS 6340 KLTH0H05544p XP_002556120.1 492106 R 559295 CDS KLTH0H05566g 255719682 8294436 493448..496768 1 NC_013084.1 highly similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation; KLTH0H05566p 496768 8294436 KLTH0H05566g Lachancea thermotolerans CBS 6340 KLTH0H05566p XP_002556121.1 493448 D 559295 CDS KLTH0H05588g 255719684 8294437 complement(496922..497407) 1 NC_013084.1 highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor or similar to YBR244W uniprot|P38143 Saccharomyces cerevisiae YBR244W GPX2 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; KLTH0H05588p 497407 8294437 KLTH0H05588g Lachancea thermotolerans CBS 6340 KLTH0H05588p XP_002556122.1 496922 R 559295 CDS KLTH0H05610g 255719686 8294438 complement(498715..499734) 1 NC_013084.1 highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p; KLTH0H05610p 499734 8294438 KLTH0H05610g Lachancea thermotolerans CBS 6340 KLTH0H05610p XP_002556123.1 498715 R 559295 CDS KLTH0H05632g 255719688 8294439 499881..501227 1 NC_013084.1 similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin; KLTH0H05632p 501227 8294439 KLTH0H05632g Lachancea thermotolerans CBS 6340 KLTH0H05632p XP_002556124.1 499881 D 559295 CDS KLTH0H05654g 255719690 8294440 complement(501335..502036) 1 NC_013084.1 similar to uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF or YGL101W uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF; KLTH0H05654p 502036 8294440 KLTH0H05654g Lachancea thermotolerans CBS 6340 KLTH0H05654p XP_002556125.1 501335 R 559295 CDS KLTH0H05676g 255719692 8294441 complement(join(502254..502654,502941..502989)) 1 NC_013084.1 highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein L29 of the large (60S) ribosomal subunit; KLTH0H05676p 502989 8294441 KLTH0H05676g Lachancea thermotolerans CBS 6340 KLTH0H05676p XP_002556126.1 502254 R 559295 CDS KLTH0H05698g 255719694 8294442 503691..505202 1 NC_013084.1 similar to uniprot|P53142 Saccharomyces cerevisiae YGL104C VPS73 Mitochondrial protein involved in vacuolar protein sorting; KLTH0H05698p 505202 8294442 KLTH0H05698g Lachancea thermotolerans CBS 6340 KLTH0H05698p XP_002556127.1 503691 D 559295 CDS KLTH0H05720g 255719696 8294443 505672..507006 1 NC_013084.1 similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes; KLTH0H05720p 507006 8294443 KLTH0H05720g Lachancea thermotolerans CBS 6340 KLTH0H05720p XP_002556128.1 505672 D 559295 CDS KLTH0H05742g 255719698 8294444 complement(507109..508227) 1 NC_013084.1 similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids; KLTH0H05742p 508227 8294444 KLTH0H05742g Lachancea thermotolerans CBS 6340 KLTH0H05742p XP_002556129.1 507109 R 559295 CDS KLTH0H05764g 255719700 8294445 508783..510153 1 NC_013084.1 similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF; KLTH0H05764p 510153 8294445 KLTH0H05764g Lachancea thermotolerans CBS 6340 KLTH0H05764p XP_002556130.1 508783 D 559295 CDS KLTH0H05786g 255719702 8294446 complement(510256..510687) 1 NC_013084.1 similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition; KLTH0H05786p 510687 8294446 KLTH0H05786g Lachancea thermotolerans CBS 6340 KLTH0H05786p XP_002556131.1 510256 R 559295 CDS KLTH0H05808g 255719704 8294447 511833..513776 1 NC_013084.1 similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF; KLTH0H05808p 513776 8294447 KLTH0H05808g Lachancea thermotolerans CBS 6340 KLTH0H05808p XP_002556132.1 511833 D 559295 CDS KLTH0H05830g 255719706 8294448 513953..514327 1 NC_013084.1 similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; KLTH0H05830p 514327 8294448 KLTH0H05830g Lachancea thermotolerans CBS 6340 KLTH0H05830p XP_002556133.1 513953 D 559295 CDS KLTH0H05852g 255719708 8294449 complement(514352..516787) 1 NC_013084.1 similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family; KLTH0H05852p 516787 8294449 KLTH0H05852g Lachancea thermotolerans CBS 6340 KLTH0H05852p XP_002556134.1 514352 R 559295 CDS KLTH0H05874g 255719710 8294450 516956..518197 1 NC_013084.1 highly similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; KLTH0H05874p 518197 8294450 KLTH0H05874g Lachancea thermotolerans CBS 6340 KLTH0H05874p XP_002556135.1 516956 D 559295 CDS KLTH0H05896g 255719712 8294451 complement(518252..521623) 1 NC_013084.1 similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF; KLTH0H05896p 521623 8294451 KLTH0H05896g Lachancea thermotolerans CBS 6340 KLTH0H05896p XP_002556136.1 518252 R 559295 CDS KLTH0H05918g 255719714 8294452 521968..523767 1 NC_013084.1 similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination; KLTH0H05918p 523767 8294452 KLTH0H05918g Lachancea thermotolerans CBS 6340 KLTH0H05918p XP_002556137.1 521968 D 559295 CDS KLTH0H05940g 255719716 8294453 complement(523846..525180) 1 NC_013084.1 similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis; KLTH0H05940p 525180 8294453 KLTH0H05940g Lachancea thermotolerans CBS 6340 KLTH0H05940p XP_002556138.1 523846 R 559295 CDS KLTH0H05962g 255719718 8294454 525898..527019 1 NC_013084.1 highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches; KLTH0H05962p 527019 8294454 KLTH0H05962g Lachancea thermotolerans CBS 6340 KLTH0H05962p XP_002556139.1 525898 D 559295 CDS KLTH0H05984g 255719720 8294455 complement(527082..527327) 1 NC_013084.1 similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; KLTH0H05984p 527327 8294455 KLTH0H05984g Lachancea thermotolerans CBS 6340 KLTH0H05984p XP_002556140.1 527082 R 559295 CDS KLTH0H06006g 255719722 8294456 527432..528967 1 NC_013084.1 highly similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes; KLTH0H06006p 528967 8294456 KLTH0H06006g Lachancea thermotolerans CBS 6340 KLTH0H06006p XP_002556141.1 527432 D 559295 CDS KLTH0H06028g 255719724 8294457 complement(529035..531251) 1 NC_013084.1 weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1; KLTH0H06028p 531251 8294457 KLTH0H06028g Lachancea thermotolerans CBS 6340 KLTH0H06028p XP_002556142.1 529035 R 559295 CDS KLTH0H06050g 255719726 8294458 complement(531454..532632) 1 NC_013084.1 similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W; KLTH0H06050p 532632 8294458 KLTH0H06050g Lachancea thermotolerans CBS 6340 KLTH0H06050p XP_002556143.1 531454 R 559295 CDS KLTH0H06072g 255719728 8294459 533185..534087 1 NC_013084.1 similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin; KLTH0H06072p 534087 8294459 KLTH0H06072g Lachancea thermotolerans CBS 6340 KLTH0H06072p XP_002556144.1 533185 D 559295 CDS KLTH0H06094g 255719730 8294460 complement(534093..536276) 1 NC_013084.1 similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters; KLTH0H06094p 536276 8294460 KLTH0H06094g Lachancea thermotolerans CBS 6340 KLTH0H06094p XP_002556145.1 534093 R 559295 CDS KLTH0H06116g 255719732 8294461 complement(536730..537692) 1 NC_013084.1 highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 involved in release from glucose repression invertase expression and sporulation associates with Snf1p; KLTH0H06116p 537692 8294461 KLTH0H06116g Lachancea thermotolerans CBS 6340 KLTH0H06116p XP_002556146.1 536730 R 559295 CDS KLTH0H06160g 255719734 8294940 complement(538741..540465) 1 NC_013084.1 similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase- promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate; KLTH0H06160p 540465 8294940 KLTH0H06160g Lachancea thermotolerans CBS 6340 KLTH0H06160p XP_002556147.1 538741 R 559295 CDS KLTH0H06182g 255719736 8294463 complement(join(542052..543392,543465..543836)) 1 NC_013084.1 similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; has similarity to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; KLTH0H06182p 543836 8294463 KLTH0H06182g Lachancea thermotolerans CBS 6340 KLTH0H06182p XP_002556148.1 542052 R 559295 CDS KLTH0H06204g 255719738 8294464 544108..546423 1 NC_013084.1 highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome; KLTH0H06204p 546423 8294464 KLTH0H06204g Lachancea thermotolerans CBS 6340 KLTH0H06204p XP_002556149.1 544108 D 559295 CDS KLTH0H06226g 255719740 8294465 546809..548341 1 NC_013084.1 some similarities with uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA; KLTH0H06226p 548341 8294465 KLTH0H06226g Lachancea thermotolerans CBS 6340 KLTH0H06226p XP_002556150.1 546809 D 559295 CDS KLTH0H06248g 255719742 8294466 complement(548756..549532) 1 NC_013084.1 highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2; KLTH0H06248p 549532 8294466 KLTH0H06248g Lachancea thermotolerans CBS 6340 KLTH0H06248p XP_002556151.1 548756 R 559295 CDS KLTH0H06270g 255719744 8294467 join(550420..550427,550541..551015) 1 NC_013084.1 some similarities with uniprot|P38325 Saccharomyces cerevisiae YBR230C Hypothetical ORF; KLTH0H06270p 551015 8294467 KLTH0H06270g Lachancea thermotolerans CBS 6340 KLTH0H06270p XP_002556152.1 550420 D 559295 CDS KLTH0H06292g 255719746 8294468 551263..553176 1 NC_013084.1 similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt- vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate; KLTH0H06292p 553176 8294468 KLTH0H06292g Lachancea thermotolerans CBS 6340 KLTH0H06292p XP_002556153.1 551263 D 559295 CDS KLTH0H06314g 255719748 8294469 complement(553271..554539) 1 NC_013084.1 some similarities with uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine; KLTH0H06314p 554539 8294469 KLTH0H06314g Lachancea thermotolerans CBS 6340 KLTH0H06314p XP_002556154.1 553271 R 559295 CDS KLTH0H06336g 255719750 8294470 555685..558462 1 NC_013084.1 similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations; KLTH0H06336p 558462 8294470 KLTH0H06336g Lachancea thermotolerans CBS 6340 KLTH0H06336p XP_002556155.1 555685 D 559295 CDS KLTH0H06358g 255719752 8294471 complement(558459..559403) 1 NC_013084.1 similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p; KLTH0H06358p 559403 8294471 KLTH0H06358g Lachancea thermotolerans CBS 6340 KLTH0H06358p XP_002556156.1 558459 R 559295 CDS KLTH0H06380g 255719754 8294472 559500..561026 1 NC_013084.1 similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1; KLTH0H06380p 561026 8294472 KLTH0H06380g Lachancea thermotolerans CBS 6340 KLTH0H06380p XP_002556157.1 559500 D 559295 CDS KLTH0H06402g 255719756 8294473 complement(561071..563329) 1 NC_013084.1 weakly similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF; KLTH0H06402p 563329 8294473 KLTH0H06402g Lachancea thermotolerans CBS 6340 KLTH0H06402p XP_002556158.1 561071 R 559295 CDS KLTH0H06446g 255719758 8294475 complement(567521..569320) 1 NC_013084.1 highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5- methyltetrahydrofolate in the methionine biosynthesis pathway; KLTH0H06446p 569320 8294475 KLTH0H06446g Lachancea thermotolerans CBS 6340 KLTH0H06446p XP_002556159.1 567521 R 559295 CDS KLTH0H06468g 255719760 8294476 570533..572245 1 NC_013084.1 similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase; KLTH0H06468p 572245 8294476 KLTH0H06468g Lachancea thermotolerans CBS 6340 KLTH0H06468p XP_002556160.1 570533 D 559295 CDS KLTH0H06490g 255719762 8294477 572398..574017 1 NC_013084.1 highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60; KLTH0H06490p 574017 8294477 KLTH0H06490g Lachancea thermotolerans CBS 6340 KLTH0H06490p XP_002556161.1 572398 D 559295 CDS KLTH0H06512g 255719764 8294478 574323..575420 1 NC_013084.1 highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex which is an evolutionarily- conserved multi-protein complex found in mitochondria; KLTH0H06512p 575420 8294478 KLTH0H06512g Lachancea thermotolerans CBS 6340 KLTH0H06512p XP_002556162.1 574323 D 559295 CDS KLTH0H06534g 255719766 8294479 576000..577634 1 NC_013084.1 similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF; KLTH0H06534p 577634 8294479 KLTH0H06534g Lachancea thermotolerans CBS 6340 KLTH0H06534p XP_002556163.1 576000 D 559295 CDS KLTH0H06556g 255719768 8294480 complement(577648..578739) 1 NC_013084.1 weakly similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy; KLTH0H06556p 578739 8294480 KLTH0H06556g Lachancea thermotolerans CBS 6340 KLTH0H06556p XP_002556164.1 577648 R 559295 CDS KLTH0H06578g 255719770 8294481 579003..579392 1 NC_013084.1 similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Subunit of the RNA polymerase II mediator complex; KLTH0H06578p 579392 8294481 KLTH0H06578g Lachancea thermotolerans CBS 6340 KLTH0H06578p XP_002556165.1 579003 D 559295 CDS KLTH0H06600g 255719772 8294482 580087..583611 1 NC_013084.1 highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase; KLTH0H06600p 583611 8294482 KLTH0H06600g Lachancea thermotolerans CBS 6340 KLTH0H06600p XP_002556166.1 580087 D 559295 CDS KLTH0H06622g 255719774 8294483 complement(583819..584490) 1 NC_013084.1 similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis; KLTH0H06622p 584490 8294483 KLTH0H06622g Lachancea thermotolerans CBS 6340 KLTH0H06622p XP_002556167.1 583819 R 559295 CDS KLTH0H06644g 255719776 8294484 complement(584893..585477) 1 NC_013084.1 similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy; KLTH0H06644p 585477 8294484 KLTH0H06644g Lachancea thermotolerans CBS 6340 KLTH0H06644p XP_002556168.1 584893 R 559295 CDS KLTH0H06666g 255719778 8294485 586283..588313 1 NC_013084.1 similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2; KLTH0H06666p 588313 8294485 KLTH0H06666g Lachancea thermotolerans CBS 6340 KLTH0H06666p XP_002556169.1 586283 D 559295 CDS KLTH0H06688g 255719780 8294486 complement(588350..589987) 1 NC_013084.1 some similarities with uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes; KLTH0H06688p 589987 8294486 KLTH0H06688g Lachancea thermotolerans CBS 6340 KLTH0H06688p XP_002556170.1 588350 R 559295 CDS KLTH0H06710g 255719782 8294487 590346..591830 1 NC_013084.1 similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF; KLTH0H06710p 591830 8294487 KLTH0H06710g Lachancea thermotolerans CBS 6340 KLTH0H06710p XP_002556171.1 590346 D 559295 CDS KLTH0H06732g 255719784 8294488 join(592074..592115,592201..592641) 1 NC_013084.1 highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N- end rule protein degradation (with Ubr1p); KLTH0H06732p 592641 8294488 KLTH0H06732g Lachancea thermotolerans CBS 6340 KLTH0H06732p XP_002556172.1 592074 D 559295 CDS KLTH0H06754g 255719786 8294489 complement(592757..593665) 1 NC_013084.1 some similarities with uniprot|P53171 Saccharomyces cerevisiae YGL057C Hypothetical protein; KLTH0H06754p 593665 8294489 KLTH0H06754g Lachancea thermotolerans CBS 6340 KLTH0H06754p XP_002556173.1 592757 R 559295 CDS KLTH0H06776g 255719788 8294490 complement(594214..595629) 1 NC_013084.1 similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations; KLTH0H06776p 595629 8294490 KLTH0H06776g Lachancea thermotolerans CBS 6340 KLTH0H06776p XP_002556174.1 594214 R 559295 CDS KLTH0H06798g 255719790 8294491 596966..598432 1 NC_013084.1 uniprot|P79047 Delta 9-fatty acid desaturase; KLTH0H06798p 598432 8294491 KLTH0H06798g Lachancea thermotolerans CBS 6340 KLTH0H06798p XP_002556175.1 596966 D 559295 CDS KLTH0H06820g 255719792 8294492 complement(598604..599494) 1 NC_013084.1 similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase; KLTH0H06820p 599494 8294492 KLTH0H06820g Lachancea thermotolerans CBS 6340 KLTH0H06820p XP_002556176.1 598604 R 559295 CDS KLTH0H06842g 255719794 8294493 complement(600623..602266) 1 NC_013084.1 some similarities with uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein; KLTH0H06842p 602266 8294493 KLTH0H06842g Lachancea thermotolerans CBS 6340 KLTH0H06842p XP_002556177.1 600623 R 559295 CDS KLTH0H06864g 255719796 8294494 604465..605523 1 NC_013084.1 some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability; KLTH0H06864p 605523 8294494 KLTH0H06864g Lachancea thermotolerans CBS 6340 KLTH0H06864p XP_002556178.1 604465 D 559295 CDS KLTH0H06886g 255719798 8294495 complement(605628..606035) 1 NC_013084.1 similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud- site selection protein Axl2p to cell surface related to Drosophila cornichon; KLTH0H06886p 606035 8294495 KLTH0H06886g Lachancea thermotolerans CBS 6340 KLTH0H06886p XP_002556179.1 605628 R 559295 CDS KLTH0H06930g 255719800 8294497 complement(608218..609003) 1 NC_013084.1 similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF; KLTH0H06930p 609003 8294497 KLTH0H06930g Lachancea thermotolerans CBS 6340 KLTH0H06930p XP_002556180.1 608218 R 559295 CDS KLTH0H06952g 255719802 8294498 complement(609143..613222) 1 NC_013084.1 weakly similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N- terminal domain that interacts with Sir4p and a C-terminal SNF2 domain; KLTH0H06952p 613222 8294498 KLTH0H06952g Lachancea thermotolerans CBS 6340 KLTH0H06952p XP_002556181.1 609143 R 559295 CDS KLTH0H06974g 255719804 8294499 complement(613530..614858) 1 NC_013084.1 highly similar to uniprot|P23776 YLR300W Saccharomyces cerevisiae EXG1 Major exo-1 3-beta-glucanase of the cell wall; KLTH0H06974p 614858 8294499 KLTH0H06974g Lachancea thermotolerans CBS 6340 KLTH0H06974p XP_002556182.1 613530 R 559295 CDS KLTH0H06996g 255719806 8294500 complement(616972..617355) 1 NC_013084.1 conserved hypothetical protein; KLTH0H06996p 617355 8294500 KLTH0H06996g Lachancea thermotolerans CBS 6340 KLTH0H06996p XP_002556183.1 616972 R 559295 CDS KLTH0H07018g 255719808 8294501 complement(618189..621167) 1 NC_013084.1 conserved hypothetical protein; KLTH0H07018p 621167 8294501 KLTH0H07018g Lachancea thermotolerans CBS 6340 KLTH0H07018p XP_002556184.1 618189 R 559295 CDS KLTH0H07040g 255719810 8294502 complement(621645..625103) 1 NC_013084.1 similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p- MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4; KLTH0H07040p 625103 8294502 KLTH0H07040g Lachancea thermotolerans CBS 6340 KLTH0H07040p XP_002556185.1 621645 R 559295 CDS KLTH0H07062g 255719812 8294503 complement(625250..627079) 1 NC_013084.1 similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation; KLTH0H07062p 627079 8294503 KLTH0H07062g Lachancea thermotolerans CBS 6340 KLTH0H07062p XP_002556186.1 625250 R 559295 CDS KLTH0H07084g 255719814 8294504 complement(627335..628615) 1 NC_013084.1 highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans; KLTH0H07084p 628615 8294504 KLTH0H07084g Lachancea thermotolerans CBS 6340 KLTH0H07084p XP_002556187.1 627335 R 559295 CDS KLTH0H07106g 255719816 8294505 628865..629506 1 NC_013084.1 some similarities with uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre- mRNA splicing; KLTH0H07106p 629506 8294505 KLTH0H07106g Lachancea thermotolerans CBS 6340 KLTH0H07106p XP_002556188.1 628865 D 559295 CDS KLTH0H07128g 255719818 8294506 complement(630668..632062) 1 NC_013084.1 some similarities with uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase; KLTH0H07128p 632062 8294506 KLTH0H07128g Lachancea thermotolerans CBS 6340 KLTH0H07128p XP_002556189.1 630668 R 559295 CDS KLTH0H07150g 255719820 8294507 632257..632700 1 NC_013084.1 conserved hypothetical protein; KLTH0H07150p 632700 8294507 KLTH0H07150g Lachancea thermotolerans CBS 6340 KLTH0H07150p XP_002556190.1 632257 D 559295 CDS KLTH0H07172g 255719822 8294508 633266..635656 1 NC_013084.1 some similarities with uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase required for high level expression of both the THI and the PDC genes; KLTH0H07172p 635656 8294508 KLTH0H07172g Lachancea thermotolerans CBS 6340 KLTH0H07172p XP_002556191.1 633266 D 559295 CDS KLTH0H07194g 255719824 8294509 complement(635744..638542) 1 NC_013084.1 similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex; KLTH0H07194p 638542 8294509 KLTH0H07194g Lachancea thermotolerans CBS 6340 KLTH0H07194p XP_002556192.1 635744 R 559295 CDS KLTH0H07216g 255719826 8294510 complement(join(638924..641053,641119..641187)) 1 NC_013084.1 similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; KLTH0H07216p 641187 8294510 KLTH0H07216g Lachancea thermotolerans CBS 6340 KLTH0H07216p XP_002556193.1 638924 R 559295 CDS KLTH0H07238g 255719828 8294511 complement(641736..642056) 1 NC_013084.1 similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane; KLTH0H07238p 642056 8294511 KLTH0H07238g Lachancea thermotolerans CBS 6340 KLTH0H07238p XP_002556194.1 641736 R 559295 CDS KLTH0H07260g 255719830 8294512 642294..643298 1 NC_013084.1 highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF; KLTH0H07260p 643298 8294512 KLTH0H07260g Lachancea thermotolerans CBS 6340 KLTH0H07260p XP_002556195.1 642294 D 559295 CDS KLTH0H07282g 255719832 8294513 644732..650635 1 NC_013084.1 similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence; KLTH0H07282p 650635 8294513 KLTH0H07282g Lachancea thermotolerans CBS 6340 KLTH0H07282p XP_002556196.1 644732 D 559295 CDS KLTH0H07304g 255719834 8294514 complement(join(650870..651985,652076..652111)) 1 NC_013084.1 similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient; KLTH0H07304p 652111 8294514 KLTH0H07304g Lachancea thermotolerans CBS 6340 KLTH0H07304p XP_002556197.1 650870 R 559295 CDS KLTH0H07326g 255719836 8294515 652347..653213 1 NC_013084.1 weakly similar to uniprot|P10355 Saccharomyces cerevisiae YER153C PET122 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet494p located in the mitochondrial inner membrane; KLTH0H07326p 653213 8294515 KLTH0H07326g Lachancea thermotolerans CBS 6340 KLTH0H07326p XP_002556198.1 652347 D 559295 CDS KLTH0H07348g 255719838 8294516 654884..655633 1 NC_013084.1 similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity; KLTH0H07348p 655633 8294516 KLTH0H07348g Lachancea thermotolerans CBS 6340 KLTH0H07348p XP_002556199.1 654884 D 559295 CDS KLTH0H07370g 255719840 8294517 655985..658330 1 NC_013084.1 some similarities with uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin; KLTH0H07370p 658330 8294517 KLTH0H07370g Lachancea thermotolerans CBS 6340 KLTH0H07370p XP_002556200.1 655985 D 559295 CDS KLTH0H07414g 255719842 8294519 complement(658932..660140) 1 NC_013084.1 some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077W SED1 Isolated as a suppressor of an erd2 deletion mutant (ERD2 is the HDEL receptor that sorts ER proteins) SED1 encodes a cell wall protein.; KLTH0H07414p 660140 8294519 KLTH0H07414g Lachancea thermotolerans CBS 6340 KLTH0H07414p XP_002556201.1 658932 R 559295 CDS KLTH0H07436g 255719844 8294520 complement(660969..662171) 1 NC_013084.1 weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p; KLTH0H07436p 662171 8294520 KLTH0H07436g Lachancea thermotolerans CBS 6340 KLTH0H07436p XP_002556202.1 660969 R 559295 CDS KLTH0H07458g 255719846 8294521 complement(662465..663388) 1 NC_013084.1 highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization; KLTH0H07458p 663388 8294521 KLTH0H07458g Lachancea thermotolerans CBS 6340 KLTH0H07458p XP_002556203.1 662465 R 559295 CDS KLTH0H07480g 255719848 8294522 663740..664927 1 NC_013084.1 weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis cell fusion; KLTH0H07480p 664927 8294522 KLTH0H07480g Lachancea thermotolerans CBS 6340 KLTH0H07480p XP_002556204.1 663740 D 559295 CDS KLTH0H07502g 255719850 8294523 complement(665022..665714) 1 NC_013084.1 highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability; KLTH0H07502p 665714 8294523 KLTH0H07502g Lachancea thermotolerans CBS 6340 KLTH0H07502p XP_002556205.1 665022 R 559295 CDS KLTH0H07524g 255719852 8294524 666040..667884 1 NC_013084.1 similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4; KLTH0H07524p 667884 8294524 KLTH0H07524g Lachancea thermotolerans CBS 6340 KLTH0H07524p XP_002556206.1 666040 D 559295 CDS KLTH0H07546g 255719854 8294525 complement(668029..670734) 1 NC_013084.1 similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6-phosphate phosphatase; KLTH0H07546p 670734 8294525 KLTH0H07546g Lachancea thermotolerans CBS 6340 KLTH0H07546p XP_002556207.1 668029 R 559295 CDS KLTH0H07568g 255719856 8294526 complement(670978..671445) 1 NC_013084.1 some similarities with uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex; KLTH0H07568p 671445 8294526 KLTH0H07568g Lachancea thermotolerans CBS 6340 KLTH0H07568p XP_002556208.1 670978 R 559295 CDS KLTH0H07590g 255719858 8294527 671945..673438 1 NC_013084.1 similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media; KLTH0H07590p 673438 8294527 KLTH0H07590g Lachancea thermotolerans CBS 6340 KLTH0H07590p XP_002556209.1 671945 D 559295 CDS KLTH0H07612g 255719860 8294528 complement(673556..673801) 1 NC_013084.1 similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; KLTH0H07612p 673801 8294528 KLTH0H07612g Lachancea thermotolerans CBS 6340 KLTH0H07612p XP_002556210.1 673556 R 559295 CDS KLTH0H07634g 255719862 8294529 674553..675140 1 NC_013084.1 highly similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation; KLTH0H07634p 675140 8294529 KLTH0H07634g Lachancea thermotolerans CBS 6340 KLTH0H07634p XP_002556211.1 674553 D 559295 CDS KLTH0H07656g 255719864 8294530 675767..676057 1 NC_013084.1 similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 The authentic non-tagged protein was localized to the mitochondria; KLTH0H07656p 676057 8294530 KLTH0H07656g Lachancea thermotolerans CBS 6340 KLTH0H07656p XP_002556212.1 675767 D 559295 CDS KLTH0H07678g 255719866 8294531 677217..679802 1 NC_013084.1 similar to uniprot|P32571 Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin hydrolase required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; KLTH0H07678p 679802 8294531 KLTH0H07678g Lachancea thermotolerans CBS 6340 KLTH0H07678p XP_002556213.1 677217 D 559295 CDS KLTH0H07700g 255719868 8294532 complement(679846..680736) 1 NC_013084.1 weakly similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; KLTH0H07700p 680736 8294532 KLTH0H07700g Lachancea thermotolerans CBS 6340 KLTH0H07700p XP_002556214.1 679846 R 559295 CDS KLTH0H07722g 255719870 8294533 680854..681510 1 NC_013084.1 similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; KLTH0H07722p 681510 8294533 KLTH0H07722g Lachancea thermotolerans CBS 6340 KLTH0H07722p XP_002556215.1 680854 D 559295 CDS KLTH0H07744g 255719872 8294534 complement(681534..682742) 1 NC_013084.1 similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control; KLTH0H07744p 682742 8294534 KLTH0H07744g Lachancea thermotolerans CBS 6340 KLTH0H07744p XP_002556216.1 681534 R 559295 CDS KLTH0H07766g 255719874 8294535 683735..684559 1 NC_013084.1 similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; KLTH0H07766p 684559 8294535 KLTH0H07766g Lachancea thermotolerans CBS 6340 KLTH0H07766p XP_002556217.1 683735 D 559295 CDS KLTH0H07788g 255719876 8294536 complement(684628..686067) 1 NC_013084.1 similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase; KLTH0H07788p 686067 8294536 KLTH0H07788g Lachancea thermotolerans CBS 6340 KLTH0H07788p XP_002556218.1 684628 R 559295 CDS KLTH0H07810g 255719878 8294537 complement(687664..689160) 1 NC_013084.1 similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF; KLTH0H07810p 689160 8294537 KLTH0H07810g Lachancea thermotolerans CBS 6340 KLTH0H07810p XP_002556219.1 687664 R 559295 CDS KLTH0H07832g 255719880 8294538 689313..689987 1 NC_013084.1 similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF; KLTH0H07832p 689987 8294538 KLTH0H07832g Lachancea thermotolerans CBS 6340 KLTH0H07832p XP_002556220.1 689313 D 559295 CDS KLTH0H07854g 255719882 8294539 complement(690041..691123) 1 NC_013084.1 similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF; KLTH0H07854p 691123 8294539 KLTH0H07854g Lachancea thermotolerans CBS 6340 KLTH0H07854p XP_002556221.1 690041 R 559295 CDS KLTH0H07876g 255719884 8294540 complement(join(691624..692058,692418..692438)) 1 NC_013084.1 highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins; KLTH0H07876p 692438 8294540 KLTH0H07876g Lachancea thermotolerans CBS 6340 KLTH0H07876p XP_002556222.1 691624 R 559295 CDS KLTH0H07898g 255719886 8294541 complement(693115..693555) 1 NC_013084.1 similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF; KLTH0H07898p 693555 8294541 KLTH0H07898g Lachancea thermotolerans CBS 6340 KLTH0H07898p XP_002556223.1 693115 R 559295 CDS KLTH0H07920g 255719888 8294542 complement(693778..695466) 1 NC_013084.1 highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3- ketosphinganine; KLTH0H07920p 695466 8294542 KLTH0H07920g Lachancea thermotolerans CBS 6340 KLTH0H07920p XP_002556224.1 693778 R 559295 CDS KLTH0H07942g 255719890 8294543 complement(696683..698269) 1 NC_013084.1 similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP- binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; KLTH0H07942p 698269 8294543 KLTH0H07942g Lachancea thermotolerans CBS 6340 KLTH0H07942p XP_002556225.1 696683 R 559295 CDS KLTH0H07964g 255719892 8294544 complement(698453..700618) 1 NC_013084.1 weakly similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N- linked and O-linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family; KLTH0H07964p 700618 8294544 KLTH0H07964g Lachancea thermotolerans CBS 6340 KLTH0H07964p XP_002556226.1 698453 R 559295 CDS KLTH0H07986g 255719894 8294545 701923..703266 1 NC_013084.1 highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins; KLTH0H07986p 703266 8294545 KLTH0H07986g Lachancea thermotolerans CBS 6340 KLTH0H07986p XP_002556227.1 701923 D 559295 CDS KLTH0H08008g 255719896 8294546 join(703423..703476,703553..703786) 1 NC_013084.1 highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay; KLTH0H08008p 703786 8294546 KLTH0H08008g Lachancea thermotolerans CBS 6340 KLTH0H08008p XP_002556228.1 703423 D 559295 CDS KLTH0H08030g 255719898 8294547 complement(703865..704317) 1 NC_013084.1 weakly similar to uniprot|P40083 Saccharomyces cerevisiae YER137C; KLTH0H08030p 704317 8294547 KLTH0H08030g Lachancea thermotolerans CBS 6340 KLTH0H08030p XP_002556229.1 703865 R 559295 CDS KLTH0H08074g 255719900 8294941 705605..706018 1 NC_013084.1 similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit; KLTH0H08074p 706018 8294941 KLTH0H08074g Lachancea thermotolerans CBS 6340 KLTH0H08074p XP_002556230.1 705605 D 559295 CDS KLTH0H08096g 255719902 8294549 706261..708327 1 NC_013084.1 similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W; KLTH0H08096p 708327 8294549 KLTH0H08096g Lachancea thermotolerans CBS 6340 KLTH0H08096p XP_002556231.1 706261 D 559295 CDS KLTH0H08118g 255719904 8294550 complement(708435..711005) 1 NC_013084.1 similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; KLTH0H08118p 711005 8294550 KLTH0H08118g Lachancea thermotolerans CBS 6340 KLTH0H08118p XP_002556232.1 708435 R 559295 CDS KLTH0H08140g 255719906 8294551 713577..714680 1 NC_013084.1 conserved hypothetical protein; KLTH0H08140p 714680 8294551 KLTH0H08140g Lachancea thermotolerans CBS 6340 KLTH0H08140p XP_002556233.1 713577 D 559295 CDS KLTH0H08162g 255719908 8294552 complement(714771..716291) 1 NC_013084.1 similar to uniprot|P38067 Saccharomyces cerevisiae YBR006w UGA2 succinate semialdehyde dehydrogenase involved in the utilization of gamma- aminobutyrate (GABA) as a nitrogen source; KLTH0H08162p 716291 8294552 KLTH0H08162g Lachancea thermotolerans CBS 6340 KLTH0H08162p XP_002556234.1 714771 R 559295 CDS KLTH0H08184g 255719910 8294553 complement(716467..719784) 1 NC_013084.1 similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria; KLTH0H08184p 719784 8294553 KLTH0H08184g Lachancea thermotolerans CBS 6340 KLTH0H08184p XP_002556235.1 716467 R 559295 CDS KLTH0H08206g 255719912 8294554 complement(719957..720508) 1 NC_013084.1 similar to uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme-activated glucose- repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences contributing to both complex assembly and DNA binding; KLTH0H08206p 720508 8294554 KLTH0H08206g Lachancea thermotolerans CBS 6340 KLTH0H08206p XP_002556236.1 719957 R 559295 CDS KLTH0H08228g 255719914 8294555 720642..722345 1 NC_013084.1 similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane mutation is suppressed by expression human p53 protein; KLTH0H08228p 722345 8294555 KLTH0H08228g Lachancea thermotolerans CBS 6340 KLTH0H08228p XP_002556237.1 720642 D 559295 CDS KLTH0H08250g 255719916 8294556 722463..724001 1 NC_013084.1 similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII; KLTH0H08250p 724001 8294556 KLTH0H08250g Lachancea thermotolerans CBS 6340 KLTH0H08250p XP_002556238.1 722463 D 559295 CDS KLTH0H08272g 255719918 8294557 complement(724024..724338) 1 NC_013084.1 similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends; KLTH0H08272p 724338 8294557 KLTH0H08272g Lachancea thermotolerans CBS 6340 KLTH0H08272p XP_002556239.1 724024 R 559295 CDS KLTH0H08294g 255719920 8294558 complement(724705..729315) 1 NC_013084.1 similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments; KLTH0H08294p 729315 8294558 KLTH0H08294g Lachancea thermotolerans CBS 6340 KLTH0H08294p XP_002556240.1 724705 R 559295 CDS KLTH0H08316g 255719922 8294559 730027..731094 1 NC_013084.1 similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phoshporylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets; KLTH0H08316p 731094 8294559 KLTH0H08316g Lachancea thermotolerans CBS 6340 KLTH0H08316p XP_002556241.1 730027 D 559295 CDS KLTH0H08338g 255719924 8294560 732210..733784 1 NC_013084.1 highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth; KLTH0H08338p 733784 8294560 KLTH0H08338g Lachancea thermotolerans CBS 6340 KLTH0H08338p XP_002556242.1 732210 D 559295 CDS KLTH0H08382g 255719926 8294562 734831..735364 1 NC_013084.1 similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF; KLTH0H08382p 735364 8294562 KLTH0H08382g Lachancea thermotolerans CBS 6340 KLTH0H08382p XP_002556243.1 734831 D 559295 CDS KLTH0H08448g 255719928 8294565 complement(736894..738819) 1 NC_013084.1 highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family; KLTH0H08448p 738819 8294565 KLTH0H08448g Lachancea thermotolerans CBS 6340 KLTH0H08448p XP_002556244.1 736894 R 559295 CDS KLTH0H08470g 255719930 8294566 complement(739626..740438) 1 NC_013084.1 similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF; KLTH0H08470p 740438 8294566 KLTH0H08470g Lachancea thermotolerans CBS 6340 KLTH0H08470p XP_002556245.1 739626 R 559295 CDS KLTH0H08492g 255719932 8294567 complement(740579..741580) 1 NC_013084.1 conserved hypothetical protein; KLTH0H08492p 741580 8294567 KLTH0H08492g Lachancea thermotolerans CBS 6340 KLTH0H08492p XP_002556246.1 740579 R 559295 CDS KLTH0H08514g 255719934 8294568 741823..743307 1 NC_013084.1 similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; KLTH0H08514p 743307 8294568 KLTH0H08514g Lachancea thermotolerans CBS 6340 KLTH0H08514p XP_002556247.1 741823 D 559295 CDS KLTH0H08602g 255719936 8294572 744917..749275 1 NC_013084.1 weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate; KLTH0H08602p 749275 8294572 KLTH0H08602g Lachancea thermotolerans CBS 6340 KLTH0H08602p XP_002556248.1 744917 D 559295 CDS KLTH0H08624g 255719938 8294573 complement(749443..750159) 1 NC_013084.1 similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit; KLTH0H08624p 750159 8294573 KLTH0H08624g Lachancea thermotolerans CBS 6340 KLTH0H08624p XP_002556249.1 749443 R 559295 CDS KLTH0H08646g 255719940 8294574 750413..752113 1 NC_013084.1 highly similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis; KLTH0H08646p 752113 8294574 KLTH0H08646g Lachancea thermotolerans CBS 6340 KLTH0H08646p XP_002556250.1 750413 D 559295 CDS KLTH0H08668g 255719942 8294575 complement(752358..752717) 1 NC_013084.1 highly similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase; KLTH0H08668p 752717 8294575 KLTH0H08668g Lachancea thermotolerans CBS 6340 KLTH0H08668p XP_002556251.1 752358 R 559295 CDS KLTH0H08690g 255719944 8294576 complement(753192..755921) 1 NC_013084.1 highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre- replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p; KLTH0H08690p 755921 8294576 KLTH0H08690g Lachancea thermotolerans CBS 6340 KLTH0H08690p XP_002556252.1 753192 R 559295 CDS KLTH0H08712g 255719946 8294577 complement(756097..757845) 1 NC_013084.1 some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication- linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I); KLTH0H08712p 757845 8294577 KLTH0H08712g Lachancea thermotolerans CBS 6340 KLTH0H08712p XP_002556253.1 756097 R 559295 CDS KLTH0H08734g 255719948 8294578 complement(758082..759479) 1 NC_013084.1 conserved hypothetical protein; KLTH0H08734p 759479 8294578 KLTH0H08734g Lachancea thermotolerans CBS 6340 KLTH0H08734p XP_002556254.1 758082 R 559295 CDS KLTH0H08756g 255719950 8294579 759812..760219 1 NC_013084.1 similar to uniprot|P32601 Saccharomyces cerevisiae YPR017C DSS4 Nucleotide release factor functioning in the post-Golgi secretory pathway required for ER-to-Golgi transport binds zinc found both on membranes and in the cytosol guanine nucleotide dissociation stimulator; KLTH0H08756p 760219 8294579 KLTH0H08756g Lachancea thermotolerans CBS 6340 KLTH0H08756p XP_002556255.1 759812 D 559295 CDS KLTH0H08778g 255719952 8294580 760522..761259 1 NC_013084.1 highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton; KLTH0H08778p 761259 8294580 KLTH0H08778g Lachancea thermotolerans CBS 6340 KLTH0H08778p XP_002556256.1 760522 D 559295 CDS KLTH0H08800g 255719954 8294581 762417..762923 1 NC_013084.1 some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF; KLTH0H08800p 762923 8294581 KLTH0H08800g Lachancea thermotolerans CBS 6340 KLTH0H08800p XP_002556257.1 762417 D 559295 CDS KLTH0H08844g 255719956 8294583 764341..765294 1 NC_013084.1 similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C; KLTH0H08844p 765294 8294583 KLTH0H08844g Lachancea thermotolerans CBS 6340 KLTH0H08844p XP_002556258.1 764341 D 559295 CDS KLTH0H08866g 255719958 8294584 join(765552..765584,765830..766033) 1 NC_013084.1 conserved hypothetical protein; KLTH0H08866p 766033 8294584 KLTH0H08866g Lachancea thermotolerans CBS 6340 KLTH0H08866p XP_002556259.1 765552 D 559295 CDS KLTH0H08888g 255719960 8294585 complement(766403..768265) 1 NC_013084.1 conserved hypothetical protein; KLTH0H08888p 768265 8294585 KLTH0H08888g Lachancea thermotolerans CBS 6340 KLTH0H08888p XP_002556260.1 766403 R 559295 CDS KLTH0H08910g 255719962 8294586 complement(768960..769820) 1 NC_013084.1 similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF; KLTH0H08910p 769820 8294586 KLTH0H08910g Lachancea thermotolerans CBS 6340 KLTH0H08910p XP_002556261.1 768960 R 559295 CDS KLTH0H08932g 255719964 8294587 770159..770515 1 NC_013084.1 highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector; KLTH0H08932p 770515 8294587 KLTH0H08932g Lachancea thermotolerans CBS 6340 KLTH0H08932p XP_002556262.1 770159 D 559295 CDS KLTH0H08954g 255719966 8294588 complement(770614..772521) 1 NC_013084.1 some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating; KLTH0H08954p 772521 8294588 KLTH0H08954g Lachancea thermotolerans CBS 6340 KLTH0H08954p XP_002556263.1 770614 R 559295 CDS KLTH0H08976g 255719968 8294589 complement(772894..774309) 1 NC_013084.1 highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization; KLTH0H08976p 774309 8294589 KLTH0H08976g Lachancea thermotolerans CBS 6340 KLTH0H08976p XP_002556264.1 772894 R 559295 CDS KLTH0H08998g 255719970 8294590 complement(774665..775600) 1 NC_013084.1 similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Hypothetical ORF; KLTH0H08998p 775600 8294590 KLTH0H08998g Lachancea thermotolerans CBS 6340 KLTH0H08998p XP_002556265.1 774665 R 559295 CDS KLTH0H09020g 255719972 8294591 complement(775981..776598) 1 NC_013084.1 conserved hypothetical protein; KLTH0H09020p 776598 8294591 KLTH0H09020g Lachancea thermotolerans CBS 6340 KLTH0H09020p XP_002556266.1 775981 R 559295 CDS KLTH0H09042g 255719974 8294592 776732..777460 1 NC_013084.1 similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases; KLTH0H09042p 777460 8294592 KLTH0H09042g Lachancea thermotolerans CBS 6340 KLTH0H09042p XP_002556267.1 776732 D 559295 CDS KLTH0H09064g 255719976 8294593 complement(777657..779027) 1 NC_013084.1 similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis- Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; KLTH0H09064p 779027 8294593 KLTH0H09064g Lachancea thermotolerans CBS 6340 KLTH0H09064p XP_002556268.1 777657 R 559295 CDS KLTH0H09086g 255719978 8294594 complement(779286..779927) 1 NC_013084.1 similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD( ) salvage pathway gene pyrazinamidase and nicotinamidase; KLTH0H09086p 779927 8294594 KLTH0H09086g Lachancea thermotolerans CBS 6340 KLTH0H09086p XP_002556269.1 779286 R 559295 CDS KLTH0H09108g 255719980 8294595 780617..783001 1 NC_013084.1 weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2; KLTH0H09108p 783001 8294595 KLTH0H09108g Lachancea thermotolerans CBS 6340 KLTH0H09108p XP_002556270.1 780617 D 559295 CDS KLTH0H09130g 255719982 8294596 783260..785347 1 NC_013084.1 similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p; KLTH0H09130p 785347 8294596 KLTH0H09130g Lachancea thermotolerans CBS 6340 KLTH0H09130p XP_002556271.1 783260 D 559295 CDS KLTH0H09152g 255719984 8294597 785536..787242 1 NC_013084.1 similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; KLTH0H09152p 787242 8294597 KLTH0H09152g Lachancea thermotolerans CBS 6340 KLTH0H09152p XP_002556272.1 785536 D 559295 CDS KLTH0H09174g 255719986 8294598 complement(787674..788042) 1 NC_013084.1 conserved hypothetical protein; KLTH0H09174p 788042 8294598 KLTH0H09174g Lachancea thermotolerans CBS 6340 KLTH0H09174p XP_002556273.1 787674 R 559295 CDS KLTH0H09196g 255719988 8294599 complement(789919..791301) 1 NC_013084.1 some similarities with uniprot|P27705 Saccharomyces cerevisiae YGL035C; KLTH0H09196p 791301 8294599 KLTH0H09196g Lachancea thermotolerans CBS 6340 KLTH0H09196p XP_002556274.1 789919 R 559295 CDS KLTH0H09218g 255719990 8294600 793572..795695 1 NC_013084.1 conserved hypothetical protein; KLTH0H09218p 795695 8294600 KLTH0H09218g Lachancea thermotolerans CBS 6340 KLTH0H09218p XP_002556275.1 793572 D 559295 CDS KLTH0H09240g 255719992 8294601 join(796183..796234,796342..796934) 1 NC_013084.1 similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes; KLTH0H09240p 796934 8294601 KLTH0H09240g Lachancea thermotolerans CBS 6340 KLTH0H09240p XP_002556276.1 796183 D 559295 CDS KLTH0H09262g 255719994 8294602 797482..798405 1 NC_013084.1 highly similar to uniprot|P78609 Pichia jadinii Uricase; KLTH0H09262p 798405 8294602 KLTH0H09262g Lachancea thermotolerans CBS 6340 KLTH0H09262p XP_002556277.1 797482 D 559295 CDS KLTH0H09284g 255719996 8294603 complement(798515..799306) 1 NC_013084.1 weakly similar to uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha-acetyl-transferase transfers acetyl group from acetyl coenzyme A to the N- terminal methionine residues of proteins; KLTH0H09284p 799306 8294603 KLTH0H09284g Lachancea thermotolerans CBS 6340 KLTH0H09284p XP_002556278.1 798515 R 559295 CDS KLTH0H09306g 255719998 8294604 complement(799475..799753) 1 NC_013084.1 similar to uniprot|P32781 Saccharomyces cerevisiae YGL032C AGA2 Adhesion subunit of a-agglutinin of a-cells C- terminal sequence acts as a ligand for alpha- agglutinin (Sag1p) during agglutination modified with O- linked oligomannosyl chains linked to anchorage subunit Aga1p via two disulfide bonds; KLTH0H09306p 799753 8294604 KLTH0H09306g Lachancea thermotolerans CBS 6340 KLTH0H09306p XP_002556279.1 799475 R 559295 CDS KLTH0H09328g 255720000 8294605 complement(800260..800727) 1 NC_013084.1 similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B; KLTH0H09328p 800727 8294605 KLTH0H09328g Lachancea thermotolerans CBS 6340 KLTH0H09328p XP_002556280.1 800260 R 559295 CDS KLTH0H09350g 255720002 8294606 join(801551..801553,801611..801925) 1 NC_013084.1 highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit; KLTH0H09350p 801925 8294606 KLTH0H09350g Lachancea thermotolerans CBS 6340 KLTH0H09350p XP_002556281.1 801551 D 559295 CDS KLTH0H09372g 255720004 8294607 complement(802071..802334) 1 NC_013084.1 highly similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein; KLTH0H09372p 802334 8294607 KLTH0H09372g Lachancea thermotolerans CBS 6340 KLTH0H09372p XP_002556282.1 802071 R 559295 CDS KLTH0H09394g 255720006 8294608 complement(802549..804354) 1 NC_013084.1 similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation; KLTH0H09394p 804354 8294608 KLTH0H09394g Lachancea thermotolerans CBS 6340 KLTH0H09394p XP_002556283.1 802549 R 559295 CDS KLTH0H09416g 255720008 8294609 806836..811422 1 NC_013084.1 similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1; KLTH0H09416p 811422 8294609 KLTH0H09416g Lachancea thermotolerans CBS 6340 KLTH0H09416p XP_002556284.1 806836 D 559295 CDS KLTH0H09438g 255720010 8294610 811653..814436 1 NC_013084.1 similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi; KLTH0H09438p 814436 8294610 KLTH0H09438g Lachancea thermotolerans CBS 6340 KLTH0H09438p XP_002556285.1 811653 D 559295 CDS KLTH0H09460g 255720012 8294611 814825..815742 1 NC_013084.1 similar to uniprot|P38892 Saccharomyces cerevisiae YHR209W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0H09460p 815742 8294611 KLTH0H09460g Lachancea thermotolerans CBS 6340 KLTH0H09460p XP_002556286.1 814825 D 559295 CDS KLTH0H09482g 255720014 8294612 complement(815929..816885) 1 NC_013084.1 highly similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall; KLTH0H09482p 816885 8294612 KLTH0H09482g Lachancea thermotolerans CBS 6340 KLTH0H09482p XP_002556287.1 815929 R 559295 CDS KLTH0H09504g 255720016 8294613 complement(join(817855..818406,818463..818465)) 1 NC_013084.1 similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes; KLTH0H09504p 818465 8294613 KLTH0H09504g Lachancea thermotolerans CBS 6340 KLTH0H09504p XP_002556288.1 817855 R 559295 CDS KLTH0H09526g 255720018 8294614 819533..820510 1 NC_013084.1 similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase; KLTH0H09526p 820510 8294614 KLTH0H09526g Lachancea thermotolerans CBS 6340 KLTH0H09526p XP_002556289.1 819533 D 559295 CDS KLTH0H09548g 255720020 8294615 complement(820616..823087) 1 NC_013084.1 similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase; KLTH0H09548p 823087 8294615 KLTH0H09548g Lachancea thermotolerans CBS 6340 KLTH0H09548p XP_002556290.1 820616 R 559295 CDS KLTH0H09570g 255720022 8294616 823303..825168 1 NC_013084.1 similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p); KLTH0H09570p 825168 8294616 KLTH0H09570g Lachancea thermotolerans CBS 6340 KLTH0H09570p XP_002556291.1 823303 D 559295 CDS KLTH0H09592g 255720024 8294617 complement(825306..828095) 1 NC_013084.1 similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate; KLTH0H09592p 828095 8294617 KLTH0H09592g Lachancea thermotolerans CBS 6340 KLTH0H09592p XP_002556292.1 825306 R 559295 CDS KLTH0H09614g 255720026 8294618 complement(828395..828796) 1 NC_013084.1 some similarities with uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 whiskey (whi) mutant forms a tetramer with VPS52 VPS53 and VPS54; KLTH0H09614p 828796 8294618 KLTH0H09614g Lachancea thermotolerans CBS 6340 KLTH0H09614p XP_002556293.1 828395 R 559295 CDS KLTH0H09636g 255720028 8294619 829108..831087 1 NC_013084.1 weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W TAX4 and to uniprot|P36115 Saccharomyces cerevisiae YKR019C IRS4; KLTH0H09636p 831087 8294619 KLTH0H09636g Lachancea thermotolerans CBS 6340 KLTH0H09636p XP_002556294.1 829108 D 559295 CDS KLTH0H09658g 255720030 8294620 831223..833400 1 NC_013084.1 similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF; KLTH0H09658p 833400 8294620 KLTH0H09658g Lachancea thermotolerans CBS 6340 KLTH0H09658p XP_002556295.1 831223 D 559295 CDS KLTH0H09680g 255720032 8294621 833533..835155 1 NC_013084.1 similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF; KLTH0H09680p 835155 8294621 KLTH0H09680g Lachancea thermotolerans CBS 6340 KLTH0H09680p XP_002556296.1 833533 D 559295 CDS KLTH0H09702g 255720034 8294622 complement(835255..836700) 1 NC_013084.1 similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes; KLTH0H09702p 836700 8294622 KLTH0H09702g Lachancea thermotolerans CBS 6340 KLTH0H09702p XP_002556297.1 835255 R 559295 CDS KLTH0H09724g 255720036 8294623 complement(836980..838563) 1 NC_013084.1 weakly similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria; KLTH0H09724p 838563 8294623 KLTH0H09724g Lachancea thermotolerans CBS 6340 KLTH0H09724p XP_002556298.1 836980 R 559295 CDS KLTH0H09746g 255720038 8294624 839114..840394 1 NC_013084.1 conserved hypothetical protein; KLTH0H09746p 840394 8294624 KLTH0H09746g Lachancea thermotolerans CBS 6340 KLTH0H09746p XP_002556299.1 839114 D 559295 CDS KLTH0H09768g 255720040 8294625 840625..841314 1 NC_013084.1 similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide- binding protein; KLTH0H09768p 841314 8294625 KLTH0H09768g Lachancea thermotolerans CBS 6340 KLTH0H09768p XP_002556300.1 840625 D 559295 CDS KLTH0H09790g 255720042 8294626 complement(841554..845168) 1 NC_013084.1 similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromosome transmission; KLTH0H09790p 845168 8294626 KLTH0H09790g Lachancea thermotolerans CBS 6340 KLTH0H09790p XP_002556301.1 841554 R 559295 CDS KLTH0H09812g 255720044 8294627 complement(845566..846210) 1 NC_013084.1 some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins; KLTH0H09812p 846210 8294627 KLTH0H09812g Lachancea thermotolerans CBS 6340 KLTH0H09812p XP_002556302.1 845566 R 559295 CDS KLTH0H09834g 255720046 8294628 complement(846452..847540) 1 NC_013084.1 some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins; KLTH0H09834p 847540 8294628 KLTH0H09834g Lachancea thermotolerans CBS 6340 KLTH0H09834p XP_002556303.1 846452 R 559295 CDS KLTH0H09856g 255720048 8294629 848950..850599 1 NC_013084.1 similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs; KLTH0H09856p 850599 8294629 KLTH0H09856g Lachancea thermotolerans CBS 6340 KLTH0H09856p XP_002556304.1 848950 D 559295 CDS KLTH0H09900g 255720050 8294631 851372..852346 1 NC_013084.1 weakly similar to uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF; KLTH0H09900p 852346 8294631 KLTH0H09900g Lachancea thermotolerans CBS 6340 KLTH0H09900p XP_002556305.1 851372 D 559295 CDS KLTH0H09922g 255720052 8294632 complement(852480..854204) 1 NC_013084.1 similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p; KLTH0H09922p 854204 8294632 KLTH0H09922g Lachancea thermotolerans CBS 6340 KLTH0H09922p XP_002556306.1 852480 R 559295 CDS KLTH0H09944g 255720054 8294633 855476..859174 1 NC_013084.1 some similarities with uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure; KLTH0H09944p 859174 8294633 KLTH0H09944g Lachancea thermotolerans CBS 6340 KLTH0H09944p XP_002556307.1 855476 D 559295 CDS KLTH0H09966g 255720056 8294634 complement(859362..863036) 1 NC_013084.1 similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells also required with Rec8p for cohesion and recombination during meiosis phylogenetically conserved SMC chromosomal ATPase family member; KLTH0H09966p 863036 8294634 KLTH0H09966g Lachancea thermotolerans CBS 6340 KLTH0H09966p XP_002556308.1 859362 R 559295 CDS KLTH0H10010g 255720058 8294636 complement(864238..865470) 1 NC_013084.1 similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1; KLTH0H10010p 865470 8294636 KLTH0H10010g Lachancea thermotolerans CBS 6340 KLTH0H10010p XP_002556309.1 864238 R 559295 CDS KLTH0H10032g 255720060 8294637 865827..867650 1 NC_013084.1 weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2; KLTH0H10032p 867650 8294637 KLTH0H10032g Lachancea thermotolerans CBS 6340 KLTH0H10032p XP_002556310.1 865827 D 559295 CDS KLTH0H10054g 255720062 8294638 complement(867826..869364) 1 NC_013084.1 similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p; KLTH0H10054p 869364 8294638 KLTH0H10054g Lachancea thermotolerans CBS 6340 KLTH0H10054p XP_002556311.1 867826 R 559295 CDS KLTH0H10142g 255720064 8294642 complement(871688..872194) 1 NC_013084.1 conserved hypothetical protein; KLTH0H10142p 872194 8294642 KLTH0H10142g Lachancea thermotolerans CBS 6340 KLTH0H10142p XP_002556312.1 871688 R 559295 CDS KLTH0H10164g 255720066 8294643 complement(872929..873558) 1 NC_013084.1 similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery; KLTH0H10164p 873558 8294643 KLTH0H10164g Lachancea thermotolerans CBS 6340 KLTH0H10164p XP_002556313.1 872929 R 559295 CDS KLTH0H10186g 255720068 8294644 873771..875396 1 NC_013084.1 similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N- acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p; KLTH0H10186p 875396 8294644 KLTH0H10186g Lachancea thermotolerans CBS 6340 KLTH0H10186p XP_002556314.1 873771 D 559295 CDS KLTH0H10208g 255720070 8294645 complement(875962..878361) 1 NC_013084.1 similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C and to uniprot|P38150 Saccharomyces cerevisiae YBR284W Hypothetical ORFs; KLTH0H10208p 878361 8294645 KLTH0H10208g Lachancea thermotolerans CBS 6340 KLTH0H10208p XP_002556315.1 875962 R 559295 CDS KLTH0H10252g 255720072 8294647 880852..882333 1 NC_013084.1 similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial; KLTH0H10252p 882333 8294647 KLTH0H10252g Lachancea thermotolerans CBS 6340 KLTH0H10252p XP_002556316.1 880852 D 559295 CDS KLTH0H10274g 255720074 8294648 complement(882443..883048) 1 NC_013084.1 weakly similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis; probable purine nucleotide-binding protein; KLTH0H10274p 883048 8294648 KLTH0H10274g Lachancea thermotolerans CBS 6340 KLTH0H10274p XP_002556317.1 882443 R 559295 CDS KLTH0H10296g 255720076 8294649 883534..888540 1 NC_013084.1 weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C- terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation; KLTH0H10296p 888540 8294649 KLTH0H10296g Lachancea thermotolerans CBS 6340 KLTH0H10296p XP_002556318.1 883534 D 559295 CDS KLTH0H10318g 255720078 8294650 complement(join(888661..890128,890228..890316)) 1 NC_013084.1 similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1 homolog of the S. pombe and mammalian Chk1 checkpoint kinases Protein kinase Chk1; KLTH0H10318p 890316 8294650 KLTH0H10318g Lachancea thermotolerans CBS 6340 KLTH0H10318p XP_002556319.1 888661 R 559295 CDS KLTH0H10340g 255720080 8294651 890416..891633 1 NC_013084.1 similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p; KLTH0H10340p 891633 8294651 KLTH0H10340g Lachancea thermotolerans CBS 6340 KLTH0H10340p XP_002556320.1 890416 D 559295 CDS KLTH0H10362g 255720082 8294652 complement(891643..892968) 1 NC_013084.1 weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF; KLTH0H10362p 892968 8294652 KLTH0H10362g Lachancea thermotolerans CBS 6340 KLTH0H10362p XP_002556321.1 891643 R 559295 CDS KLTH0H10384g 255720084 8294653 893051..894493 1 NC_013084.1 similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C; KLTH0H10384p 894493 8294653 KLTH0H10384g Lachancea thermotolerans CBS 6340 KLTH0H10384p XP_002556322.1 893051 D 559295 CDS KLTH0H10406g 255720086 8294654 complement(894542..897769) 1 NC_013084.1 highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus; KLTH0H10406p 897769 8294654 KLTH0H10406g Lachancea thermotolerans CBS 6340 KLTH0H10406p XP_002556323.1 894542 R 559295 CDS KLTH0H10428g 255720088 8294655 complement(898234..900537) 1 NC_013084.1 weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p; KLTH0H10428p 900537 8294655 KLTH0H10428g Lachancea thermotolerans CBS 6340 KLTH0H10428p XP_002556324.1 898234 R 559295 CDS KLTH0H10450g 255720090 8294656 complement(901280..902218) 1 NC_013084.1 highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex; KLTH0H10450p 902218 8294656 KLTH0H10450g Lachancea thermotolerans CBS 6340 KLTH0H10450p XP_002556325.1 901280 R 559295 CDS KLTH0H10472g 255720092 8294657 complement(902520..903968) 1 NC_013084.1 similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane.; KLTH0H10472p 903968 8294657 KLTH0H10472g Lachancea thermotolerans CBS 6340 KLTH0H10472p XP_002556326.1 902520 R 559295 CDS KLTH0H10494g 255720094 8294658 complement(904424..905893) 1 NC_013084.1 conserved hypothetical protein; KLTH0H10494p 905893 8294658 KLTH0H10494g Lachancea thermotolerans CBS 6340 KLTH0H10494p XP_002556327.1 904424 R 559295 CDS KLTH0H10516g 255720096 8294659 complement(908060..908779) 1 NC_013084.1 similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Hypothetical ORF; KLTH0H10516p 908779 8294659 KLTH0H10516g Lachancea thermotolerans CBS 6340 KLTH0H10516p XP_002556328.1 908060 R 559295 CDS KLTH0H10538g 255720098 8294660 910730..912778 1 NC_013084.1 weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains; KLTH0H10538p 912778 8294660 KLTH0H10538g Lachancea thermotolerans CBS 6340 KLTH0H10538p XP_002556329.1 910730 D 559295 CDS KLTH0H10560g 255720100 8294661 complement(912880..914133) 1 NC_013084.1 similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0H10560p 914133 8294661 KLTH0H10560g Lachancea thermotolerans CBS 6340 KLTH0H10560p XP_002556330.1 912880 R 559295 CDS KLTH0H10582g 255720102 8294662 914695..916440 1 NC_013084.1 weakly similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase; KLTH0H10582p 916440 8294662 KLTH0H10582g Lachancea thermotolerans CBS 6340 KLTH0H10582p XP_002556331.1 914695 D 559295 CDS KLTH0H10604g 255720104 8294663 916591..918201 1 NC_013084.1 similar to uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF; KLTH0H10604p 918201 8294663 KLTH0H10604g Lachancea thermotolerans CBS 6340 KLTH0H10604p XP_002556332.1 916591 D 559295 CDS KLTH0H10626g 255720106 8294664 complement(918216..919424) 1 NC_013084.1 similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein; KLTH0H10626p 919424 8294664 KLTH0H10626g Lachancea thermotolerans CBS 6340 KLTH0H10626p XP_002556333.1 918216 R 559295 CDS KLTH0H10648g 255720108 8294665 complement(919601..920932) 1 NC_013084.1 highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway potential Cdc28p substrate; KLTH0H10648p 920932 8294665 KLTH0H10648g Lachancea thermotolerans CBS 6340 KLTH0H10648p XP_002556334.1 919601 R 559295 CDS KLTH0H10670g 255720110 8294666 921312..921719 1 NC_013084.1 similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria; KLTH0H10670p 921719 8294666 KLTH0H10670g Lachancea thermotolerans CBS 6340 KLTH0H10670p XP_002556335.1 921312 D 559295 CDS KLTH0H10692g 255720112 8294667 complement(921787..923862) 1 NC_013084.1 similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC; KLTH0H10692p 923862 8294667 KLTH0H10692g Lachancea thermotolerans CBS 6340 KLTH0H10692p XP_002556336.1 921787 R 559295 CDS KLTH0H10714g 255720114 8294668 complement(924077..924397) 1 NC_013084.1 similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit; KLTH0H10714p 924397 8294668 KLTH0H10714g Lachancea thermotolerans CBS 6340 KLTH0H10714p XP_002556337.1 924077 R 559295 CDS KLTH0H10736g 255720116 8294669 complement(924558..926990) 1 NC_013084.1 similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity; KLTH0H10736p 926990 8294669 KLTH0H10736g Lachancea thermotolerans CBS 6340 KLTH0H10736p XP_002556338.1 924558 R 559295 CDS KLTH0H10758g 255720118 8294670 complement(927171..928358) 1 NC_013084.1 similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains; KLTH0H10758p 928358 8294670 KLTH0H10758g Lachancea thermotolerans CBS 6340 KLTH0H10758p XP_002556339.1 927171 R 559295 CDS KLTH0H10780g 255720120 8294671 complement(928608..929552) 1 NC_013084.1 similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase; KLTH0H10780p 929552 8294671 KLTH0H10780g Lachancea thermotolerans CBS 6340 KLTH0H10780p XP_002556340.1 928608 R 559295 CDS KLTH0H10802g 255720122 8294672 complement(929775..930050) 1 NC_013084.1 similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF; KLTH0H10802p 930050 8294672 KLTH0H10802g Lachancea thermotolerans CBS 6340 KLTH0H10802p XP_002556341.1 929775 R 559295 CDS KLTH0H10824g 255720124 8294673 930412..931143 1 NC_013084.1 similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit; KLTH0H10824p 931143 8294673 KLTH0H10824g Lachancea thermotolerans CBS 6340 KLTH0H10824p XP_002556342.1 930412 D 559295 CDS KLTH0H10846g 255720126 8294674 931560..932609 1 NC_013084.1 similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF; KLTH0H10846p 932609 8294674 KLTH0H10846g Lachancea thermotolerans CBS 6340 KLTH0H10846p XP_002556343.1 931560 D 559295 CDS KLTH0H10868g 255720128 8294675 complement(932678..935029) 1 NC_013084.1 similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle; KLTH0H10868p 935029 8294675 KLTH0H10868g Lachancea thermotolerans CBS 6340 KLTH0H10868p XP_002556344.1 932678 R 559295 CDS KLTH0H10890g 255720130 8294676 936960..937565 1 NC_013084.1 some similarities with uniprot|P40366 Saccharomyces cerevisiae YJL065C DLS1 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p Isw2p and Dpb4p involved in inheritance of telomeric silencing; KLTH0H10890p 937565 8294676 KLTH0H10890g Lachancea thermotolerans CBS 6340 KLTH0H10890p XP_002556345.1 936960 D 559295 CDS KLTH0H10912g 255720132 8294677 938065..938928 1 NC_013084.1 weakly similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches; KLTH0H10912p 938928 8294677 KLTH0H10912g Lachancea thermotolerans CBS 6340 KLTH0H10912p XP_002556346.1 938065 D 559295 CDS KLTH0H10934g 255720134 8294678 939374..940579 1 NC_013084.1 similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes; KLTH0H10934p 940579 8294678 KLTH0H10934g Lachancea thermotolerans CBS 6340 KLTH0H10934p XP_002556347.1 939374 D 559295 CDS KLTH0H10956g 255720136 8294679 940867..941763 1 NC_013084.1 similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF; KLTH0H10956p 941763 8294679 KLTH0H10956g Lachancea thermotolerans CBS 6340 KLTH0H10956p XP_002556348.1 940867 D 559295 CDS KLTH0H10978g 255720138 8294680 complement(941811..943547) 1 NC_013084.1 similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF; KLTH0H10978p 943547 8294680 KLTH0H10978g Lachancea thermotolerans CBS 6340 KLTH0H10978p XP_002556349.1 941811 R 559295 CDS KLTH0H11000g 255720140 8294681 complement(943669..946260) 1 NC_013084.1 similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF; KLTH0H11000p 946260 8294681 KLTH0H11000g Lachancea thermotolerans CBS 6340 KLTH0H11000p XP_002556350.1 943669 R 559295 CDS KLTH0H11022g 255720142 8294682 947447..949195 1 NC_013084.1 similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data; KLTH0H11022p 949195 8294682 KLTH0H11022g Lachancea thermotolerans CBS 6340 KLTH0H11022p XP_002556351.1 947447 D 559295 CDS KLTH0H11044g 255720144 8294683 949487..949924 1 NC_013084.1 similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit; KLTH0H11044p 949924 8294683 KLTH0H11044g Lachancea thermotolerans CBS 6340 KLTH0H11044p XP_002556352.1 949487 D 559295 CDS KLTH0H11066g 255720146 8294684 complement(join(950234..951696,951763..951772)) 1 NC_013084.1 highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential; KLTH0H11066p 951772 8294684 KLTH0H11066g Lachancea thermotolerans CBS 6340 KLTH0H11066p XP_002556353.1 950234 R 559295 CDS KLTH0H11088g 255720148 8294685 952862..953170 1 NC_013084.1 similar to uniprot|P38341 Saccharomyces cerevisiae YBR262C Hypothetical protein; KLTH0H11088p 953170 8294685 KLTH0H11088g Lachancea thermotolerans CBS 6340 KLTH0H11088p XP_002556354.1 952862 D 559295 CDS KLTH0H11110g 255720150 8294686 953330..954022 1 NC_013084.1 similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; KLTH0H11110p 954022 8294686 KLTH0H11110g Lachancea thermotolerans CBS 6340 KLTH0H11110p XP_002556355.1 953330 D 559295 CDS KLTH0H11154g 255720152 8294944 955400..957517 1 NC_013084.1 similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization; KLTH0H11154p 957517 8294944 KLTH0H11154g Lachancea thermotolerans CBS 6340 KLTH0H11154p XP_002556356.1 955400 D 559295 CDS KLTH0H11176g 255720154 8294688 complement(957667..959991) 1 NC_013084.1 weakly similar to uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition; KLTH0H11176p 959991 8294688 KLTH0H11176g Lachancea thermotolerans CBS 6340 KLTH0H11176p XP_002556357.1 957667 R 559295 CDS KLTH0H11198g 255720156 8294689 complement(960669..962633) 1 NC_013084.1 some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition; KLTH0H11198p 962633 8294689 KLTH0H11198g Lachancea thermotolerans CBS 6340 KLTH0H11198p XP_002556358.1 960669 R 559295 CDS KLTH0H11220g 255720158 8294690 962932..963324 1 NC_013084.1 similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; KLTH0H11220p 963324 8294690 KLTH0H11220g Lachancea thermotolerans CBS 6340 KLTH0H11220p XP_002556359.1 962932 D 559295 CDS KLTH0H11242g 255720160 8294691 complement(963370..964194) 1 NC_013084.1 similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P; KLTH0H11242p 964194 8294691 KLTH0H11242g Lachancea thermotolerans CBS 6340 KLTH0H11242p XP_002556360.1 963370 R 559295 CDS KLTH0H11264g 255720162 8294692 964294..965517 1 NC_013084.1 similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF; KLTH0H11264p 965517 8294692 KLTH0H11264g Lachancea thermotolerans CBS 6340 KLTH0H11264p XP_002556361.1 964294 D 559295 CDS KLTH0H11286g 255720164 8294693 complement(965578..967500) 1 NC_013084.1 similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; KLTH0H11286p 967500 8294693 KLTH0H11286g Lachancea thermotolerans CBS 6340 KLTH0H11286p XP_002556362.1 965578 R 559295 CDS KLTH0H11308g 255720166 8294694 968074..968979 1 NC_013084.1 conserved hypothetical protein; KLTH0H11308p 968979 8294694 KLTH0H11308g Lachancea thermotolerans CBS 6340 KLTH0H11308p XP_002556363.1 968074 D 559295 CDS KLTH0H11330g 255720168 8294695 969133..971628 1 NC_013084.1 similar to uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing; KLTH0H11330p 971628 8294695 KLTH0H11330g Lachancea thermotolerans CBS 6340 KLTH0H11330p XP_002556364.1 969133 D 559295 CDS KLTH0H11396g 255720170 8294698 complement(973355..974668) 1 NC_013084.1 similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and to YFR014C uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1 Calmodulin-dependent protein kinase; KLTH0H11396p 974668 8294698 KLTH0H11396g Lachancea thermotolerans CBS 6340 KLTH0H11396p XP_002556365.1 973355 R 559295 CDS KLTH0H11418g 255720172 8294699 complement(975327..977459) 1 NC_013084.1 highly similar to uniprot|P23337 Saccharomyces cerevisiae or YLR258W uniprot|P27472 Saccharomyces cerevisiae; KLTH0H11418p 977459 8294699 KLTH0H11418g Lachancea thermotolerans CBS 6340 KLTH0H11418p XP_002556366.1 975327 R 559295 CDS KLTH0H11440g 255720174 8294700 complement(978785..981295) 1 NC_013084.1 conserved hypothetical protein; KLTH0H11440p 981295 8294700 KLTH0H11440g Lachancea thermotolerans CBS 6340 KLTH0H11440p XP_002556367.1 978785 R 559295 CDS KLTH0H11462g 255720176 8294701 complement(981666..982340) 1 NC_013084.1 no similarity; KLTH0H11462p 982340 8294701 KLTH0H11462g Lachancea thermotolerans CBS 6340 KLTH0H11462p XP_002556368.1 981666 R 559295 CDS KLTH0H11484g 255720178 8294702 complement(982395..985235) 1 NC_013084.1 some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF; KLTH0H11484p 985235 8294702 KLTH0H11484g Lachancea thermotolerans CBS 6340 KLTH0H11484p XP_002556369.1 982395 R 559295 CDS KLTH0H11506g 255720180 8294703 complement(985252..986166) 1 NC_013084.1 weakly similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF; KLTH0H11506p 986166 8294703 KLTH0H11506g Lachancea thermotolerans CBS 6340 KLTH0H11506p XP_002556370.1 985252 R 559295 CDS KLTH0H11550g 255720182 8294705 986923..988524 1 NC_013084.1 similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF; KLTH0H11550p 988524 8294705 KLTH0H11550g Lachancea thermotolerans CBS 6340 KLTH0H11550p XP_002556371.1 986923 D 559295 CDS KLTH0H11572g 255720184 8294706 complement(989095..992808) 1 NC_013084.1 similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1; KLTH0H11572p 992808 8294706 KLTH0H11572g Lachancea thermotolerans CBS 6340 KLTH0H11572p XP_002556372.1 989095 R 559295 CDS KLTH0H11594g 255720186 8294707 994752..995753 1 NC_013084.1 similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF; KLTH0H11594p 995753 8294707 KLTH0H11594g Lachancea thermotolerans CBS 6340 KLTH0H11594p XP_002556373.1 994752 D 559295 CDS KLTH0H11616g 255720188 8294708 996041..996616 1 NC_013084.1 similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 homolog of nuclear distribution factor NudE NUDEL; KLTH0H11616p 996616 8294708 KLTH0H11616g Lachancea thermotolerans CBS 6340 KLTH0H11616p XP_002556374.1 996041 D 559295 CDS KLTH0H11638g 255720190 8294709 complement(996661..998358) 1 NC_013084.1 similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF; KLTH0H11638p 998358 8294709 KLTH0H11638g Lachancea thermotolerans CBS 6340 KLTH0H11638p XP_002556375.1 996661 R 559295 CDS KLTH0H11660g 255720192 8294710 complement(998622..999224) 1 NC_013084.1 similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17 required for ethanol metabolismand induced by heat shock localized to the inner mitochondrial membrane; KLTH0H11660p 999224 8294710 KLTH0H11660g Lachancea thermotolerans CBS 6340 KLTH0H11660p XP_002556376.1 998622 R 559295 CDS KLTH0H11682g 255720194 8294711 1000534..1003563 1 NC_013084.1 some similarities with uniprot|P36111 Saccharomyces cerevisiae YKR015C Hypothetical ORF; KLTH0H11682p 1003563 8294711 KLTH0H11682g Lachancea thermotolerans CBS 6340 KLTH0H11682p XP_002556377.1 1000534 D 559295 CDS KLTH0H11704g 255720196 8294712 complement(1003625..1007182) 1 NC_013084.1 similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1; KLTH0H11704p 1007182 8294712 KLTH0H11704g Lachancea thermotolerans CBS 6340 KLTH0H11704p XP_002556378.1 1003625 R 559295 CDS KLTH0H11726g 255720198 8294713 complement(1007328..1009139) 1 NC_013084.1 weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF; KLTH0H11726p 1009139 8294713 KLTH0H11726g Lachancea thermotolerans CBS 6340 KLTH0H11726p XP_002556379.1 1007328 R 559295 CDS KLTH0H11748g 255720200 8294714 1009647..1010546 1 NC_013084.1 highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm; KLTH0H11748p 1010546 8294714 KLTH0H11748g Lachancea thermotolerans CBS 6340 KLTH0H11748p XP_002556380.1 1009647 D 559295 CDS KLTH0H11770g 255720202 8294715 1010683..1011153 1 NC_013084.1 highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin- associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex; KLTH0H11770p 1011153 8294715 KLTH0H11770g Lachancea thermotolerans CBS 6340 KLTH0H11770p XP_002556381.1 1010683 D 559295 CDS KLTH0H11792g 255720204 8294716 complement(1011230..1011598) 1 NC_013084.1 some similarities with uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF; KLTH0H11792p 1011598 8294716 KLTH0H11792g Lachancea thermotolerans CBS 6340 KLTH0H11792p XP_002556382.1 1011230 R 559295 CDS KLTH0H11858g 255720206 8294719 1013677..1015374 1 NC_013084.1 some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations; KLTH0H11858p 1015374 8294719 KLTH0H11858g Lachancea thermotolerans CBS 6340 KLTH0H11858p XP_002556383.1 1013677 D 559295 CDS KLTH0H11880g 255720208 8294720 1016025..1016711 1 NC_013084.1 no similarity; KLTH0H11880p 1016711 8294720 KLTH0H11880g Lachancea thermotolerans CBS 6340 KLTH0H11880p XP_002556384.1 1016025 D 559295 CDS KLTH0H11902g 255720210 8294721 1017096..1020230 1 NC_013084.1 highly similar to uniprot|P53978 Saccharomyces cerevisiae YNL014W HEF3 Translational elongation factor EF- 3 paralog of YEF3 and member of the ABC superfamily stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome normally expressed in zinc deficient cells; KLTH0H11902p 1020230 8294721 KLTH0H11902g Lachancea thermotolerans CBS 6340 KLTH0H11902p XP_002556385.1 1017096 D 559295 CDS KLTH0H11924g 255720212 8294722 1020731..1022587 1 NC_013084.1 similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W SPO1 Meiosis-specific protein with similarity to phospholipase B; KLTH0H11924p 1022587 8294722 KLTH0H11924g Lachancea thermotolerans CBS 6340 KLTH0H11924p XP_002556386.1 1020731 D 559295 CDS KLTH0H11946g 255720214 8294723 1022709..1023404 1 NC_013084.1 similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0H11946p 1023404 8294723 KLTH0H11946g Lachancea thermotolerans CBS 6340 KLTH0H11946p XP_002556387.1 1022709 D 559295 CDS KLTH0H11968g 255720216 8294724 complement(1023447..1024880) 1 NC_013084.1 similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF; KLTH0H11968p 1024880 8294724 KLTH0H11968g Lachancea thermotolerans CBS 6340 KLTH0H11968p XP_002556388.1 1023447 R 559295 CDS KLTH0H11990g 255720218 8294725 1025209..1025922 1 NC_013084.1 highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF; KLTH0H11990p 1025922 8294725 KLTH0H11990g Lachancea thermotolerans CBS 6340 KLTH0H11990p XP_002556389.1 1025209 D 559295 CDS KLTH0H12012g 255720220 8294726 1026586..1027827 1 NC_013084.1 highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha- ketoglutarate levels are elevated during growth on non- fermentable carbon sources and reduced during growth on glucose; KLTH0H12012p 1027827 8294726 KLTH0H12012g Lachancea thermotolerans CBS 6340 KLTH0H12012p XP_002556390.1 1026586 D 559295 CDS KLTH0H12056g 255720222 8294728 join(1029016..1029240,1029312..1030673) 1 NC_013084.1 similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype; KLTH0H12056p 1030673 8294728 KLTH0H12056g Lachancea thermotolerans CBS 6340 KLTH0H12056p XP_002556391.1 1029016 D 559295 CDS KLTH0H12078g 255720224 8294729 1030928..1032382 1 NC_013084.1 highly similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs) probable rRNA pseudouridine synthase binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p; KLTH0H12078p 1032382 8294729 KLTH0H12078g Lachancea thermotolerans CBS 6340 KLTH0H12078p XP_002556392.1 1030928 D 559295 CDS KLTH0H12100g 255720226 8294730 complement(1032695..1033747) 1 NC_013084.1 some similarities with uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog; KLTH0H12100p 1033747 8294730 KLTH0H12100g Lachancea thermotolerans CBS 6340 KLTH0H12100p XP_002556393.1 1032695 R 559295 CDS KLTH0H12122g 255720228 8294731 1034092..1035003 1 NC_013084.1 highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat; KLTH0H12122p 1035003 8294731 KLTH0H12122g Lachancea thermotolerans CBS 6340 KLTH0H12122p XP_002556394.1 1034092 D 559295 CDS KLTH0H12144g 255720230 8294732 complement(1035244..1037466) 1 NC_013084.1 some similarities with uniprot|P48743 Saccharomyces cerevisiae YLR176C; KLTH0H12144p 1037466 8294732 KLTH0H12144g Lachancea thermotolerans CBS 6340 KLTH0H12144p XP_002556395.1 1035244 R 559295 CDS KLTH0H12166g 255720232 8294733 1038164..1039096 1 NC_013084.1 similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C; KLTH0H12166p 1039096 8294733 KLTH0H12166g Lachancea thermotolerans CBS 6340 KLTH0H12166p XP_002556396.1 1038164 D 559295 CDS KLTH0H12188g 255720234 8294734 1039347..1040441 1 NC_013084.1 highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway; KLTH0H12188p 1040441 8294734 KLTH0H12188g Lachancea thermotolerans CBS 6340 KLTH0H12188p XP_002556397.1 1039347 D 559295 CDS KLTH0H12210g 255720236 8294735 complement(1040665..1042101) 1 NC_013084.1 highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post- transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria; KLTH0H12210p 1042101 8294735 KLTH0H12210g Lachancea thermotolerans CBS 6340 KLTH0H12210p XP_002556398.1 1040665 R 559295 CDS KLTH0H12232g 255720238 8294736 1042774..1043598 1 NC_013084.1 similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth; KLTH0H12232p 1043598 8294736 KLTH0H12232g Lachancea thermotolerans CBS 6340 KLTH0H12232p XP_002556399.1 1042774 D 559295 CDS KLTH0H12254g 255720240 8294737 complement(1043666..1044793) 1 NC_013084.1 similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion; KLTH0H12254p 1044793 8294737 KLTH0H12254g Lachancea thermotolerans CBS 6340 KLTH0H12254p XP_002556400.1 1043666 R 559295 CDS KLTH0H12276g 255720242 8294738 1044900..1049720 1 NC_013084.1 similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; KLTH0H12276p 1049720 8294738 KLTH0H12276g Lachancea thermotolerans CBS 6340 KLTH0H12276p XP_002556401.1 1044900 D 559295 CDS KLTH0H12298g 255720244 8294739 complement(1051410..1052150) 1 NC_013084.1 similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex; KLTH0H12298p 1052150 8294739 KLTH0H12298g Lachancea thermotolerans CBS 6340 KLTH0H12298p XP_002556402.1 1051410 R 559295 CDS KLTH0H12320g 255720246 8294740 1052341..1053459 1 NC_013084.1 similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit; KLTH0H12320p 1053459 8294740 KLTH0H12320g Lachancea thermotolerans CBS 6340 KLTH0H12320p XP_002556403.1 1052341 D 559295 CDS KLTH0H12342g 255720248 8294741 complement(1053769..1054674) 1 NC_013084.1 highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria; KLTH0H12342p 1054674 8294741 KLTH0H12342g Lachancea thermotolerans CBS 6340 KLTH0H12342p XP_002556404.1 1053769 R 559295 CDS KLTH0H12386g 255720250 8294743 1057263..1058171 1 NC_013084.1 some similarities with uniprot|P25587 Saccharomyces cerevisiae YCL005W Hypothetical ORF; KLTH0H12386p 1058171 8294743 KLTH0H12386g Lachancea thermotolerans CBS 6340 KLTH0H12386p XP_002556405.1 1057263 D 559295 CDS KLTH0H12430g 255720252 8294745 1058448..1060019 1 NC_013084.1 similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate- limiting step of cardiolipin biosynthesis; KLTH0H12430p 1060019 8294745 KLTH0H12430g Lachancea thermotolerans CBS 6340 KLTH0H12430p XP_002556406.1 1058448 D 559295 CDS KLTH0H12452g 255720254 8294746 1060750..1061292 1 NC_013084.1 similar to uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER; KLTH0H12452p 1061292 8294746 KLTH0H12452g Lachancea thermotolerans CBS 6340 KLTH0H12452p XP_002556407.1 1060750 D 559295 CDS KLTH0H12474g 255720256 8294747 1061585..1062745 1 NC_013084.1 similar to uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA-binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division; KLTH0H12474p 1062745 8294747 KLTH0H12474g Lachancea thermotolerans CBS 6340 KLTH0H12474p XP_002556408.1 1061585 D 559295 CDS KLTH0H12518g 255720258 8294749 complement(1064018..1065013) 1 NC_013084.1 highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM; KLTH0H12518p 1065013 8294749 KLTH0H12518g Lachancea thermotolerans CBS 6340 KLTH0H12518p XP_002556409.1 1064018 R 559295 CDS KLTH0H12540g 255720260 8294750 1065257..1065799 1 NC_013084.1 some similarities with uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit; KLTH0H12540p 1065799 8294750 KLTH0H12540g Lachancea thermotolerans CBS 6340 KLTH0H12540p XP_002556410.1 1065257 D 559295 CDS KLTH0H12562g 255720262 8294751 1066070..1067803 1 NC_013084.1 conserved hypothetical protein; KLTH0H12562p 1067803 8294751 KLTH0H12562g Lachancea thermotolerans CBS 6340 KLTH0H12562p XP_002556411.1 1066070 D 559295 CDS KLTH0H12584g 255720264 8294752 complement(1067912..1068649) 1 NC_013084.1 similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0H12584p 1068649 8294752 KLTH0H12584g Lachancea thermotolerans CBS 6340 KLTH0H12584p XP_002556412.1 1067912 R 559295 CDS KLTH0H12606g 255720266 8294753 complement(1069190..1070623) 1 NC_013084.1 highly similar to uniprot|P00890 Saccharomyces cerevisiae YNR001C CIT1 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate the rate-limiting enzyme of the TCA cycle nuclear encoded mitochondrial protein; KLTH0H12606p 1070623 8294753 KLTH0H12606g Lachancea thermotolerans CBS 6340 KLTH0H12606p XP_002556413.1 1069190 R 559295 CDS KLTH0H12650g 255720268 8294755 1072961..1074592 1 NC_013084.1 similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W SAT4 Ser/Thr protein kinase involved in salt tolerance; KLTH0H12650p 1074592 8294755 KLTH0H12650g Lachancea thermotolerans CBS 6340 KLTH0H12650p XP_002556414.1 1072961 D 559295 CDS KLTH0H12672g 255720270 8294756 complement(1074950..1078585) 1 NC_013084.1 conserved hypothetical protein; KLTH0H12672p 1078585 8294756 KLTH0H12672g Lachancea thermotolerans CBS 6340 KLTH0H12672p XP_002556415.1 1074950 R 559295 CDS KLTH0H12694g 255720272 8294757 complement(1078832..1079629) 1 NC_013084.1 highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress; KLTH0H12694p 1079629 8294757 KLTH0H12694g Lachancea thermotolerans CBS 6340 KLTH0H12694p XP_002556416.1 1078832 R 559295 CDS KLTH0H12716g 255720274 8294758 1079836..1080882 1 NC_013084.1 similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C MHT1 S-methylmethionine-homocysteine methyltransferase; KLTH0H12716p 1080882 8294758 KLTH0H12716g Lachancea thermotolerans CBS 6340 KLTH0H12716p XP_002556417.1 1079836 D 559295 CDS KLTH0H12738g 255720276 8294759 complement(1080924..1081856) 1 NC_013084.1 highly similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; KLTH0H12738p 1081856 8294759 KLTH0H12738g Lachancea thermotolerans CBS 6340 KLTH0H12738p XP_002556418.1 1080924 R 559295 CDS KLTH0H12760g 255720278 8294760 complement(1083450..1086512) 1 NC_013084.1 similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase; KLTH0H12760p 1086512 8294760 KLTH0H12760g Lachancea thermotolerans CBS 6340 KLTH0H12760p XP_002556419.1 1083450 R 559295 CDS KLTH0H12782g 255720280 8294761 complement(1087253..1088227) 1 NC_013084.1 similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF; KLTH0H12782p 1088227 8294761 KLTH0H12782g Lachancea thermotolerans CBS 6340 KLTH0H12782p XP_002556420.1 1087253 R 559295 CDS KLTH0H12804g 255720282 8294762 1089822..1096220 1 NC_013084.1 similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis; KLTH0H12804p 1096220 8294762 KLTH0H12804g Lachancea thermotolerans CBS 6340 KLTH0H12804p XP_002556421.1 1089822 D 559295 CDS KLTH0H12870g 255720284 8294765 1098531..1100117 1 NC_013084.1 similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5- bisphosphate- binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre- autophagosomal structure; KLTH0H12870p 1100117 8294765 KLTH0H12870g Lachancea thermotolerans CBS 6340 KLTH0H12870p XP_002556422.1 1098531 D 559295 CDS KLTH0H12892g 255720286 8294766 1100704..1102995 1 NC_013084.1 weakly similar to uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase; KLTH0H12892p 1102995 8294766 KLTH0H12892g Lachancea thermotolerans CBS 6340 KLTH0H12892p XP_002556423.1 1100704 D 559295 CDS KLTH0H12914g 255720288 8294767 complement(1103700..1104494) 1 NC_013084.1 conserved hypothetical protein; KLTH0H12914p 1104494 8294767 KLTH0H12914g Lachancea thermotolerans CBS 6340 KLTH0H12914p XP_002556424.1 1103700 R 559295 CDS KLTH0H12936g 255720290 8294768 1105361..1107550 1 NC_013084.1 similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase; KLTH0H12936p 1107550 8294768 KLTH0H12936g Lachancea thermotolerans CBS 6340 KLTH0H12936p XP_002556425.1 1105361 D 559295 CDS KLTH0H12958g 255720292 8294769 1107939..1109858 1 NC_013084.1 similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae; KLTH0H12958p 1109858 8294769 KLTH0H12958g Lachancea thermotolerans CBS 6340 KLTH0H12958p XP_002556426.1 1107939 D 559295 CDS KLTH0H12980g 255720294 8294770 complement(join(1110123..1111259,1111344..1111406)) 1 NC_013084.1 similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84; KLTH0H12980p 1111406 8294770 KLTH0H12980g Lachancea thermotolerans CBS 6340 KLTH0H12980p XP_002556427.1 1110123 R 559295 CDS KLTH0H13002g 255720296 8294771 1112292..1113323 1 NC_013084.1 weakly similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W YSC83; KLTH0H13002p 1113323 8294771 KLTH0H13002g Lachancea thermotolerans CBS 6340 KLTH0H13002p XP_002556428.1 1112292 D 559295 CDS KLTH0H13024g 255720298 8294772 complement(1113635..1115299) 1 NC_013084.1 highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA; KLTH0H13024p 1115299 8294772 KLTH0H13024g Lachancea thermotolerans CBS 6340 KLTH0H13024p XP_002556429.1 1113635 R 559295 CDS KLTH0H13046g 255720300 8294773 1115590..1117617 1 NC_013084.1 highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability; KLTH0H13046p 1117617 8294773 KLTH0H13046g Lachancea thermotolerans CBS 6340 KLTH0H13046p XP_002556430.1 1115590 D 559295 CDS KLTH0H13068g 255720302 8294774 complement(1117700..1118713) 1 NC_013084.1 similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control; KLTH0H13068p 1118713 8294774 KLTH0H13068g Lachancea thermotolerans CBS 6340 KLTH0H13068p XP_002556431.1 1117700 R 559295 CDS KLTH0H13090g 255720304 8294775 1118994..1120091 1 NC_013084.1 conserved hypothetical protein; KLTH0H13090p 1120091 8294775 KLTH0H13090g Lachancea thermotolerans CBS 6340 KLTH0H13090p XP_002556432.1 1118994 D 559295 CDS KLTH0H13134g 255720306 8294777 1121004..1121864 1 NC_013084.1 similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p; KLTH0H13134p 1121864 8294777 KLTH0H13134g Lachancea thermotolerans CBS 6340 KLTH0H13134p XP_002556433.1 1121004 D 559295 CDS KLTH0H13156g 255720308 8294778 complement(1122041..1123558) 1 NC_013084.1 similar to uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase enabling it to act on key substrates to effect a decrease in CDK/B- cyclin activity and mitotic exit; KLTH0H13156p 1123558 8294778 KLTH0H13156g Lachancea thermotolerans CBS 6340 KLTH0H13156p XP_002556434.1 1122041 R 559295 CDS KLTH0H13288g 255720310 8294794 1160383..1161453 1 NC_013084.1 similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs; KLTH0H13288p 1161453 8294794 KLTH0H13288g Lachancea thermotolerans CBS 6340 KLTH0H13288p XP_002556435.1 1160383 D 559295 CDS KLTH0H13310g 255720312 8294795 complement(1161557..1163341) 1 NC_013084.1 weakly similar to uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; KLTH0H13310p 1163341 8294795 KLTH0H13310g Lachancea thermotolerans CBS 6340 KLTH0H13310p XP_002556436.1 1161557 R 559295 CDS KLTH0H13332g 255720314 8294796 1164850..1165311 1 NC_013084.1 similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C Hypothetical ORF; KLTH0H13332p 1165311 8294796 KLTH0H13332g Lachancea thermotolerans CBS 6340 KLTH0H13332p XP_002556437.1 1164850 D 559295 CDS KLTH0H13354g 255720316 8294797 complement(join(1165485..1166953,1167017..1167035)) 1 NC_013084.1 similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds; KLTH0H13354p 1167035 8294797 KLTH0H13354g Lachancea thermotolerans CBS 6340 KLTH0H13354p XP_002556438.1 1165485 R 559295 CDS KLTH0H13376g 255720318 8294798 complement(1167211..1168833) 1 NC_013084.1 similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily expression is induced by low levels of glucose and repressed by high levels of glucose; KLTH0H13376p 1168833 8294798 KLTH0H13376g Lachancea thermotolerans CBS 6340 KLTH0H13376p XP_002556439.1 1167211 R 559295 CDS KLTH0H13398g 255720320 8294799 complement(1169665..1171428) 1 NC_013084.1 similar to uniprot|P38967 Saccharomyces cerevisiae YOL020W TAT2 Tryptophan permease high affinity; KLTH0H13398p 1171428 8294799 KLTH0H13398g Lachancea thermotolerans CBS 6340 KLTH0H13398p XP_002556440.1 1169665 R 559295 CDS KLTH0H13420g 255720322 8294800 1172833..1175793 1 NC_013084.1 highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family; KLTH0H13420p 1175793 8294800 KLTH0H13420g Lachancea thermotolerans CBS 6340 KLTH0H13420p XP_002556441.1 1172833 D 559295 CDS KLTH0H13442g 255720324 8294801 complement(1175860..1178118) 1 NC_013084.1 highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA; KLTH0H13442p 1178118 8294801 KLTH0H13442g Lachancea thermotolerans CBS 6340 KLTH0H13442p XP_002556442.1 1175860 R 559295 CDS KLTH0H13508g 255720326 8294804 1180327..1181541 1 NC_013084.1 similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability; KLTH0H13508p 1181541 8294804 KLTH0H13508g Lachancea thermotolerans CBS 6340 KLTH0H13508p XP_002556443.1 1180327 D 559295 CDS KLTH0H13530g 255720328 8294805 complement(1181636..1183654) 1 NC_013084.1 similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2; KLTH0H13530p 1183654 8294805 KLTH0H13530g Lachancea thermotolerans CBS 6340 KLTH0H13530p XP_002556444.1 1181636 R 559295 CDS KLTH0H13552g 255720330 8294806 1185801..1187438 1 NC_013084.1 similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane; KLTH0H13552p 1187438 8294806 KLTH0H13552g Lachancea thermotolerans CBS 6340 KLTH0H13552p XP_002556445.1 1185801 D 559295 CDS KLTH0H13574g 255720332 8294807 complement(1187658..1188890) 1 NC_013084.1 conserved hypothetical protein; KLTH0H13574p 1188890 8294807 KLTH0H13574g Lachancea thermotolerans CBS 6340 KLTH0H13574p XP_002556446.1 1187658 R 559295 CDS KLTH0H13596g 255720334 8294808 complement(1189109..1189714) 1 NC_013084.1 some similarities with uniprot|P43598 Saccharomyces cerevisiae YFR017C Putative protein of unknown function; KLTH0H13596p 1189714 8294808 KLTH0H13596g Lachancea thermotolerans CBS 6340 KLTH0H13596p XP_002556447.1 1189109 R 559295 CDS KLTH0H13618g 255720336 8294809 complement(1189806..1191788) 1 NC_013084.1 some similarities with uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 Protein involved in determination of longevity; KLTH0H13618p 1191788 8294809 KLTH0H13618g Lachancea thermotolerans CBS 6340 KLTH0H13618p XP_002556448.1 1189806 R 559295 CDS KLTH0H13640g 255720338 8294810 1193279..1194529 1 NC_013084.1 highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis; KLTH0H13640p 1194529 8294810 KLTH0H13640g Lachancea thermotolerans CBS 6340 KLTH0H13640p XP_002556449.1 1193279 D 559295 CDS KLTH0H13662g 255720340 8294811 complement(1194653..1196329) 1 NC_013084.1 similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 Probable homolog of mammalian DNA polymerase beta may function in double-stranded DNA break repair DNA polymerase IV; KLTH0H13662p 1196329 8294811 KLTH0H13662g Lachancea thermotolerans CBS 6340 KLTH0H13662p XP_002556450.1 1194653 R 559295 CDS KLTH0H13684g 255720342 8294812 complement(1196689..1197594) 1 NC_013084.1 similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Hypothetical ORF; KLTH0H13684p 1197594 8294812 KLTH0H13684g Lachancea thermotolerans CBS 6340 KLTH0H13684p XP_002556451.1 1196689 R 559295 CDS KLTH0H13706g 255720344 8294813 1198255..1199034 1 NC_013084.1 similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Hypothetical ORF; KLTH0H13706p 1199034 8294813 KLTH0H13706g Lachancea thermotolerans CBS 6340 KLTH0H13706p XP_002556452.1 1198255 D 559295 CDS KLTH0H13728g 255720346 8294814 1199825..1201510 1 NC_013084.1 similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes; KLTH0H13728p 1201510 8294814 KLTH0H13728g Lachancea thermotolerans CBS 6340 KLTH0H13728p XP_002556453.1 1199825 D 559295 CDS KLTH0H13750g 255720348 8294815 1201915..1202304 1 NC_013084.1 weakly similar to uniprot|P40342 Saccharomyces cerevisiae YNR004W Hypothetical ORF; KLTH0H13750p 1202304 8294815 KLTH0H13750g Lachancea thermotolerans CBS 6340 KLTH0H13750p XP_002556454.1 1201915 D 559295 CDS KLTH0H13772g 255720350 8294816 complement(1202354..1205398) 1 NC_013084.1 similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion; KLTH0H13772p 1205398 8294816 KLTH0H13772g Lachancea thermotolerans CBS 6340 KLTH0H13772p XP_002556455.1 1202354 R 559295 CDS KLTH0H13794g 255720352 8294817 complement(1205666..1207783) 1 NC_013084.1 highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)- fusion protein localizes to the cytoplasm in a punctate pattern; KLTH0H13794p 1207783 8294817 KLTH0H13794g Lachancea thermotolerans CBS 6340 KLTH0H13794p XP_002556456.1 1205666 R 559295 CDS KLTH0H13816g 255720354 8294818 complement(join(1208214..1208910,1209008..1209012)) 1 NC_013084.1 highly similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1 6- bisphosphatase (FBPase) cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro; KLTH0H13816p 1209012 8294818 KLTH0H13816g Lachancea thermotolerans CBS 6340 KLTH0H13816p XP_002556457.1 1208214 R 559295 CDS KLTH0H13838g 255720356 8294819 complement(1209331..1209546) 1 NC_013084.1 similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Subunit of the RSC chromatin remodeling complex; KLTH0H13838p 1209546 8294819 KLTH0H13838g Lachancea thermotolerans CBS 6340 KLTH0H13838p XP_002556458.1 1209331 R 559295 CDS KLTH0H13860g 255720358 8294820 1210300..1211118 1 NC_013084.1 similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome; KLTH0H13860p 1211118 8294820 KLTH0H13860g Lachancea thermotolerans CBS 6340 KLTH0H13860p XP_002556459.1 1210300 D 559295 CDS KLTH0H13882g 255720360 8294821 complement(1211129..1212175) 1 NC_013084.1 similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles; KLTH0H13882p 1212175 8294821 KLTH0H13882g Lachancea thermotolerans CBS 6340 KLTH0H13882p XP_002556460.1 1211129 R 559295 CDS KLTH0H13926g 255720362 8294823 complement(1212915..1214606) 1 NC_013084.1 highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions; KLTH0H13926p 1214606 8294823 KLTH0H13926g Lachancea thermotolerans CBS 6340 KLTH0H13926p XP_002556461.1 1212915 R 559295 CDS KLTH0H13948g 255720364 8294824 complement(1215314..1216807) 1 NC_013084.1 similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies; KLTH0H13948p 1216807 8294824 KLTH0H13948g Lachancea thermotolerans CBS 6340 KLTH0H13948p XP_002556462.1 1215314 R 559295 CDS KLTH0H13970g 255720366 8294825 1217045..1217623 1 NC_013084.1 similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake member of the Ras superfamily of G-proteins; KLTH0H13970p 1217623 8294825 KLTH0H13970g Lachancea thermotolerans CBS 6340 KLTH0H13970p XP_002556463.1 1217045 D 559295 CDS KLTH0H13992g 255720368 8294826 complement(1217826..1218773) 1 NC_013084.1 conserved hypothetical protein; KLTH0H13992p 1218773 8294826 KLTH0H13992g Lachancea thermotolerans CBS 6340 KLTH0H13992p XP_002556464.1 1217826 R 559295 CDS KLTH0H14014g 255720370 8294827 complement(1220076..1221035) 1 NC_013084.1 some similarities with uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism as suggested by computational analysis of large-scale protein- protein interaction data GFP-fusion protein localizes to the nuclear periphery; KLTH0H14014p 1221035 8294827 KLTH0H14014g Lachancea thermotolerans CBS 6340 KLTH0H14014p XP_002556465.1 1220076 R 559295 CDS KLTH0H14036g 255720372 8294828 complement(1223258..1223920) 1 NC_013084.1 weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex; KLTH0H14036p 1223920 8294828 KLTH0H14036g Lachancea thermotolerans CBS 6340 KLTH0H14036p XP_002556466.1 1223258 R 559295 CDS KLTH0H14058g 255720374 8294829 1223984..1224844 1 NC_013084.1 similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; KLTH0H14058p 1224844 8294829 KLTH0H14058g Lachancea thermotolerans CBS 6340 KLTH0H14058p XP_002556467.1 1223984 D 559295 CDS KLTH0H14080g 255720376 8294830 1224962..1226368 1 NC_013084.1 similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase; KLTH0H14080p 1226368 8294830 KLTH0H14080g Lachancea thermotolerans CBS 6340 KLTH0H14080p XP_002556468.1 1224962 D 559295 CDS KLTH0H14102g 255720378 8294831 1226474..1228129 1 NC_013084.1 similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical ORF; KLTH0H14102p 1228129 8294831 KLTH0H14102g Lachancea thermotolerans CBS 6340 KLTH0H14102p XP_002556469.1 1226474 D 559295 CDS KLTH0H14146g 255720380 8294939 complement(1228951..1229214) 1 NC_013084.1 highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; KLTH0H14146p 1229214 8294939 KLTH0H14146g Lachancea thermotolerans CBS 6340 KLTH0H14146p XP_002556470.1 1228951 R 559295 CDS KLTH0H14168g 255720382 8294833 complement(1229546..1230343) 1 NC_013084.1 highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase; KLTH0H14168p 1230343 8294833 KLTH0H14168g Lachancea thermotolerans CBS 6340 KLTH0H14168p XP_002556471.1 1229546 R 559295 CDS KLTH0H14190g 255720384 8294834 1230708..1232033 1 NC_013084.1 conserved hypothetical protein; KLTH0H14190p 1232033 8294834 KLTH0H14190g Lachancea thermotolerans CBS 6340 KLTH0H14190p XP_002556472.1 1230708 D 559295 CDS KLTH0H14212g 255720386 8294835 complement(1232141..1236340) 1 NC_013084.1 similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W; KLTH0H14212p 1236340 8294835 KLTH0H14212g Lachancea thermotolerans CBS 6340 KLTH0H14212p XP_002556473.1 1232141 R 559295 CDS KLTH0H14234g 255720388 8294836 1236691..1237878 1 NC_013084.1 similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity; KLTH0H14234p 1237878 8294836 KLTH0H14234g Lachancea thermotolerans CBS 6340 KLTH0H14234p XP_002556474.1 1236691 D 559295 CDS KLTH0H14256g 255720390 8294837 complement(1238169..1241963) 1 NC_013084.1 weakly similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate; KLTH0H14256p 1241963 8294837 KLTH0H14256g Lachancea thermotolerans CBS 6340 KLTH0H14256p XP_002556475.1 1238169 R 559295 CDS KLTH0H14278g 255720392 8294838 1242646..1242972 1 NC_013084.1 highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase; KLTH0H14278p 1242972 8294838 KLTH0H14278g Lachancea thermotolerans CBS 6340 KLTH0H14278p XP_002556476.1 1242646 D 559295 CDS KLTH0H14300g 255720394 8294839 1243241..1246354 1 NC_013084.1 similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription- coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein; KLTH0H14300p 1246354 8294839 KLTH0H14300g Lachancea thermotolerans CBS 6340 KLTH0H14300p XP_002556477.1 1243241 D 559295 CDS KLTH0H14322g 255720396 8294840 1246601..1248646 1 NC_013084.1 similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF; KLTH0H14322p 1248646 8294840 KLTH0H14322g Lachancea thermotolerans CBS 6340 KLTH0H14322p XP_002556478.1 1246601 D 559295 CDS KLTH0H14344g 255720398 8294841 complement(1249055..1249699) 1 NC_013084.1 highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; KLTH0H14344p 1249699 8294841 KLTH0H14344g Lachancea thermotolerans CBS 6340 KLTH0H14344p XP_002556479.1 1249055 R 559295 CDS KLTH0H14366g 255720400 8294842 complement(1250262..1252820) 1 NC_013084.1 similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability; KLTH0H14366p 1252820 8294842 KLTH0H14366g Lachancea thermotolerans CBS 6340 KLTH0H14366p XP_002556480.1 1250262 R 559295 CDS KLTH0H14388g 255720402 8294843 1253251..1256637 1 NC_013084.1 some similarities with uniprot|P47107 Saccharomyces cerevisiae YJR039W Hypothetical ORF; KLTH0H14388p 1256637 8294843 KLTH0H14388g Lachancea thermotolerans CBS 6340 KLTH0H14388p XP_002556481.1 1253251 D 559295 CDS KLTH0H14410g 255720404 8294844 complement(1256918..1257301) 1 NC_013084.1 highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri- snRNP involved in mRNA splicing, similar to human 15.5K protein; KLTH0H14410p 1257301 8294844 KLTH0H14410g Lachancea thermotolerans CBS 6340 KLTH0H14410p XP_002556482.1 1256918 R 559295 CDS KLTH0H14432g 255720406 8294845 1257730..1260015 1 NC_013084.1 similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post- Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates; KLTH0H14432p 1260015 8294845 KLTH0H14432g Lachancea thermotolerans CBS 6340 KLTH0H14432p XP_002556483.1 1257730 D 559295 CDS KLTH0H14454g 255720408 8294846 complement(1260084..1263539) 1 NC_013084.1 similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis; KLTH0H14454p 1263539 8294846 KLTH0H14454g Lachancea thermotolerans CBS 6340 KLTH0H14454p XP_002556484.1 1260084 R 559295 CDS KLTH0H14476g 255720410 8294847 1263772..1265991 1 NC_013084.1 similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; KLTH0H14476p 1265991 8294847 KLTH0H14476g Lachancea thermotolerans CBS 6340 KLTH0H14476p XP_002556485.1 1263772 D 559295 CDS KLTH0H14498g 255720412 8294848 complement(1266270..1266758) 1 NC_013084.1 similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis; KLTH0H14498p 1266758 8294848 KLTH0H14498g Lachancea thermotolerans CBS 6340 KLTH0H14498p XP_002556486.1 1266270 R 559295 CDS KLTH0H14520g 255720414 8294849 complement(1267120..1268259) 1 NC_013084.1 weakly similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error-prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p; KLTH0H14520p 1268259 8294849 KLTH0H14520g Lachancea thermotolerans CBS 6340 KLTH0H14520p XP_002556487.1 1267120 R 559295 CDS KLTH0H14564g 255720416 8294851 complement(1269411..1270289) 1 NC_013084.1 conserved hypothetical protein; KLTH0H14564p 1270289 8294851 KLTH0H14564g Lachancea thermotolerans CBS 6340 KLTH0H14564p XP_002556488.1 1269411 R 559295 CDS KLTH0H14586g 255720418 8294852 1272008..1272922 1 NC_013084.1 similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C; KLTH0H14586p 1272922 8294852 KLTH0H14586g Lachancea thermotolerans CBS 6340 KLTH0H14586p XP_002556489.1 1272008 D 559295 CDS KLTH0H14608g 255720420 8294853 1273683..1274525 1 NC_013084.1 similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl- thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology; KLTH0H14608p 1274525 8294853 KLTH0H14608g Lachancea thermotolerans CBS 6340 KLTH0H14608p XP_002556490.1 1273683 D 559295 CDS KLTH0H14630g 255720422 8294854 complement(1274522..1275388) 1 NC_013084.1 similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6- pentakisphosphate 2- kinase nuclear protein required for synthesis of 1 2 3 4 5 6-hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable; KLTH0H14630p 1275388 8294854 KLTH0H14630g Lachancea thermotolerans CBS 6340 KLTH0H14630p XP_002556491.1 1274522 R 559295 CDS KLTH0H14652g 255720424 8294855 1275543..1276685 1 NC_013084.1 highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric; KLTH0H14652p 1276685 8294855 KLTH0H14652g Lachancea thermotolerans CBS 6340 KLTH0H14652p XP_002556492.1 1275543 D 559295 CDS KLTH0H14674g 255720426 8294856 1277240..1278565 1 NC_013084.1 similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane has a conserved methyltransferase motif multicopy suppressor of respiratory defects caused by OXA1 mutations; KLTH0H14674p 1278565 8294856 KLTH0H14674g Lachancea thermotolerans CBS 6340 KLTH0H14674p XP_002556493.1 1277240 D 559295 CDS KLTH0H14696g 255720428 8294857 complement(1278620..1279732) 1 NC_013084.1 highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p).; KLTH0H14696p 1279732 8294857 KLTH0H14696g Lachancea thermotolerans CBS 6340 KLTH0H14696p XP_002556494.1 1278620 R 559295 CDS KLTH0H14718g 255720430 8294858 1280187..1281674 1 NC_013084.1 similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya; KLTH0H14718p 1281674 8294858 KLTH0H14718g Lachancea thermotolerans CBS 6340 KLTH0H14718p XP_002556495.1 1280187 D 559295 CDS KLTH0H14740g 255720432 8294859 1282770..1283450 1 NC_013084.1 weakly similar to uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity; KLTH0H14740p 1283450 8294859 KLTH0H14740g Lachancea thermotolerans CBS 6340 KLTH0H14740p XP_002556496.1 1282770 D 559295 CDS KLTH0H14784g 255720434 8294861 1283834..1285378 1 NC_013084.1 weakly similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W Hypothetical ORF; KLTH0H14784p 1285378 8294861 KLTH0H14784g Lachancea thermotolerans CBS 6340 KLTH0H14784p XP_002556497.1 1283834 D 559295 CDS KLTH0H14806g 255720436 8294862 join(1285442..1285493,1285556..1286544) 1 NC_013084.1 similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules; KLTH0H14806p 1286544 8294862 KLTH0H14806g Lachancea thermotolerans CBS 6340 KLTH0H14806p XP_002556498.1 1285442 D 559295 CDS KLTH0H14828g 255720438 8294863 complement(1286533..1287288) 1 NC_013084.1 similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Hypothetical ORF; KLTH0H14828p 1287288 8294863 KLTH0H14828g Lachancea thermotolerans CBS 6340 KLTH0H14828p XP_002556499.1 1286533 R 559295 CDS KLTH0H14850g 255720440 8294864 1287375..1289555 1 NC_013084.1 highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3- epoxide a step in ergosterol biosynthesis; KLTH0H14850p 1289555 8294864 KLTH0H14850g Lachancea thermotolerans CBS 6340 KLTH0H14850p XP_002556500.1 1287375 D 559295 CDS KLTH0H14872g 255720442 8294865 complement(1289638..1291509) 1 NC_013084.1 weakly similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein; KLTH0H14872p 1291509 8294865 KLTH0H14872g Lachancea thermotolerans CBS 6340 KLTH0H14872p XP_002556501.1 1289638 R 559295 CDS KLTH0H14894g 255720444 8294866 1291716..1291895 1 NC_013084.1 highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs which are required for pseudouridylation and processing of pre-18S rRNA; KLTH0H14894p 1291895 8294866 KLTH0H14894g Lachancea thermotolerans CBS 6340 KLTH0H14894p XP_002556502.1 1291716 D 559295 CDS KLTH0H14916g 255720446 8294867 complement(1292038..1292256) 1 NC_013084.1 highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore; KLTH0H14916p 1292256 8294867 KLTH0H14916g Lachancea thermotolerans CBS 6340 KLTH0H14916p XP_002556503.1 1292038 R 559295 CDS KLTH0H14938g 255720448 8294868 1292539..1295181 1 NC_013084.1 similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability; KLTH0H14938p 1295181 8294868 KLTH0H14938g Lachancea thermotolerans CBS 6340 KLTH0H14938p XP_002556504.1 1292539 D 559295 CDS KLTH0H14960g 255720450 8294869 1295363..1296490 1 NC_013084.1 highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism; KLTH0H14960p 1296490 8294869 KLTH0H14960g Lachancea thermotolerans CBS 6340 KLTH0H14960p XP_002556505.1 1295363 D 559295 CDS KLTH0H14982g 255720452 8294870 1298040..1299089 1 NC_013084.1 conserved hypothetical protein; KLTH0H14982p 1299089 8294870 KLTH0H14982g Lachancea thermotolerans CBS 6340 KLTH0H14982p XP_002556506.1 1298040 D 559295 CDS KLTH0H15004g 255720454 8294871 1299314..1301458 1 NC_013084.1 highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD( ) synthetase essential for the formation of NAD( ) from nicotinic acid adenine dinucleotide; KLTH0H15004p 1301458 8294871 KLTH0H15004g Lachancea thermotolerans CBS 6340 KLTH0H15004p XP_002556507.1 1299314 D 559295 CDS KLTH0H15026g 255720456 8294872 complement(1301507..1302604) 1 NC_013084.1 similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein; KLTH0H15026p 1302604 8294872 KLTH0H15026g Lachancea thermotolerans CBS 6340 KLTH0H15026p XP_002556508.1 1301507 R 559295 CDS KLTH0H15048g 255720458 8294873 1303474..1304364 1 NC_013084.1 some similarities with uniprot|P38704 Saccharomyces cerevisiae YHR006W STP2 Transcription factor activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids activates transcription of amino acid permease genes; KLTH0H15048p 1304364 8294873 KLTH0H15048g Lachancea thermotolerans CBS 6340 KLTH0H15048p XP_002556509.1 1303474 D 559295 CDS KLTH0H15070g 255720460 8294874 1304724..1306040 1 NC_013084.1 similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p; KLTH0H15070p 1306040 8294874 KLTH0H15070g Lachancea thermotolerans CBS 6340 KLTH0H15070p XP_002556510.1 1304724 D 559295 CDS KLTH0H15114g 255720462 8294876 1307989..1309188 1 NC_013084.1 similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase; KLTH0H15114p 1309188 8294876 KLTH0H15114g Lachancea thermotolerans CBS 6340 KLTH0H15114p XP_002556511.1 1307989 D 559295 CDS KLTH0H15136g 255720464 8294877 1309316..1313776 1 NC_013084.1 conserved hypothetical protein; KLTH0H15136p 1313776 8294877 KLTH0H15136g Lachancea thermotolerans CBS 6340 KLTH0H15136p XP_002556512.1 1309316 D 559295 CDS KLTH0H15158g 255720466 8294878 1313973..1317038 1 NC_013084.1 similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth; KLTH0H15158p 1317038 8294878 KLTH0H15158g Lachancea thermotolerans CBS 6340 KLTH0H15158p XP_002556513.1 1313973 D 559295 CDS KLTH0H15180g 255720468 8294879 complement(1317079..1318563) 1 NC_013084.1 similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; KLTH0H15180p 1318563 8294879 KLTH0H15180g Lachancea thermotolerans CBS 6340 KLTH0H15180p XP_002556514.1 1317079 R 559295 CDS KLTH0H15202g 255720470 8294880 complement(1319631..1321118) 1 NC_013084.1 similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p; KLTH0H15202p 1321118 8294880 KLTH0H15202g Lachancea thermotolerans CBS 6340 KLTH0H15202p XP_002556515.1 1319631 R 559295 CDS KLTH0H15224g 255720472 8294881 1321783..1322553 1 NC_013084.1 similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF; KLTH0H15224p 1322553 8294881 KLTH0H15224g Lachancea thermotolerans CBS 6340 KLTH0H15224p XP_002556516.1 1321783 D 559295 CDS KLTH0H15246g 255720474 8294882 1322967..1323902 1 NC_013084.1 highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2; KLTH0H15246p 1323902 8294882 KLTH0H15246g Lachancea thermotolerans CBS 6340 KLTH0H15246p XP_002556517.1 1322967 D 559295 CDS KLTH0H15268g 255720476 8294883 complement(1324060..1325406) 1 NC_013084.1 similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter; KLTH0H15268p 1325406 8294883 KLTH0H15268g Lachancea thermotolerans CBS 6340 KLTH0H15268p XP_002556518.1 1324060 R 559295 CDS KLTH0H15312g 255720478 8294885 complement(1327047..1328756) 1 NC_013084.1 weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein; KLTH0H15312p 1328756 8294885 KLTH0H15312g Lachancea thermotolerans CBS 6340 KLTH0H15312p XP_002556519.1 1327047 R 559295 CDS KLTH0H15334g 255720480 8294886 complement(1329504..1331039) 1 NC_013084.1 highly similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA; KLTH0H15334p 1331039 8294886 KLTH0H15334g Lachancea thermotolerans CBS 6340 KLTH0H15334p XP_002556520.1 1329504 R 559295 CDS KLTH0H15356g 255720482 8294887 complement(1331327..1332154) 1 NC_013084.1 similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)- resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; KLTH0H15356p 1332154 8294887 KLTH0H15356g Lachancea thermotolerans CBS 6340 KLTH0H15356p XP_002556521.1 1331327 R 559295 CDS KLTH0H15378g 255720484 8294888 complement(1332472..1332912) 1 NC_013084.1 highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YMR242c RPL20A and highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YOR312C RPL20B; KLTH0H15378p 1332912 8294888 KLTH0H15378g Lachancea thermotolerans CBS 6340 KLTH0H15378p XP_002556522.1 1332472 R 559295 CDS KLTH0H15400g 255720486 8294889 complement(1333954..1334769) 1 NC_013084.1 some similarities with uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage; KLTH0H15400p 1334769 8294889 KLTH0H15400g Lachancea thermotolerans CBS 6340 KLTH0H15400p XP_002556523.1 1333954 R 559295 CDS KLTH0H15422g 255720488 8294890 1335797..1336819 1 NC_013084.1 weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W Protein of unknown function found in the cytoplasm and the nucleus potential Cdc28p substrate; KLTH0H15422p 1336819 8294890 KLTH0H15422g Lachancea thermotolerans CBS 6340 KLTH0H15422p XP_002556524.1 1335797 D 559295 CDS KLTH0H15444g 255720490 8294891 complement(1337046..1338332) 1 NC_013084.1 similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1; KLTH0H15444p 1338332 8294891 KLTH0H15444g Lachancea thermotolerans CBS 6340 KLTH0H15444p XP_002556525.1 1337046 R 559295 CDS KLTH0H15466g 255720492 8294892 1338955..1339431 1 NC_013084.1 no similarity; KLTH0H15466p 1339431 8294892 KLTH0H15466g Lachancea thermotolerans CBS 6340 KLTH0H15466p XP_002556526.1 1338955 D 559295 CDS KLTH0H15488g 255720494 8294893 1340078..1341115 1 NC_013084.1 similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF; KLTH0H15488p 1341115 8294893 KLTH0H15488g Lachancea thermotolerans CBS 6340 KLTH0H15488p XP_002556527.1 1340078 D 559295 CDS KLTH0H15510g 255720496 8294894 complement(1341509..1342507) 1 NC_013084.1 similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized stress- responsive protein that negatively regulates the H( )- ATPase Pma1p induced by heat shock ethanol treatment weak organic acid glucose limitation and entry into stationary phase; KLTH0H15510p 1342507 8294894 KLTH0H15510g Lachancea thermotolerans CBS 6340 KLTH0H15510p XP_002556528.1 1341509 R 559295 CDS KLTH0H15532g 255720498 8294895 complement(1343365..1343694) 1 NC_013084.1 similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF; KLTH0H15532p 1343694 8294895 KLTH0H15532g Lachancea thermotolerans CBS 6340 KLTH0H15532p XP_002556529.1 1343365 R 559295 CDS KLTH0H15554g 255720500 8294896 1344296..1345708 1 NC_013084.1 weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; KLTH0H15554p 1345708 8294896 KLTH0H15554g Lachancea thermotolerans CBS 6340 KLTH0H15554p XP_002556530.1 1344296 D 559295 CDS KLTH0H15576g 255720502 8294897 1346402..1347862 1 NC_013084.1 similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase; KLTH0H15576p 1347862 8294897 KLTH0H15576g Lachancea thermotolerans CBS 6340 KLTH0H15576p XP_002556531.1 1346402 D 559295 CDS KLTH0H15598g 255720504 8294898 1348220..1348543 1 NC_013084.1 highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component; KLTH0H15598p 1348543 8294898 KLTH0H15598g Lachancea thermotolerans CBS 6340 KLTH0H15598p XP_002556532.1 1348220 D 559295 CDS KLTH0H15620g 255720506 8294899 complement(join(1348876..1349471,1349712..1349715)) 1 NC_013084.1 highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082w RPL13A ribosomal protein or uniprot|P40212 Saccharomyces cerevisiae YMR142c RPL13B; KLTH0H15620p 1349715 8294899 KLTH0H15620g Lachancea thermotolerans CBS 6340 KLTH0H15620p XP_002556533.1 1348876 R 559295 CDS KLTH0H15642g 255720508 8294900 join(1350520..1350543,1350837..1351244) 1 NC_013084.1 highly similar to uniprot|P40213 Saccharomyces cerevisiae YMR143w RPS16A or uniprot|P40213 Saccharomyces cerevisiae YDL083c RPS16B; KLTH0H15642p 1351244 8294900 KLTH0H15642g Lachancea thermotolerans CBS 6340 KLTH0H15642p XP_002556534.1 1350520 D 559295 CDS KLTH0H15664g 255720510 8294901 1352301..1353305 1 NC_013084.1 weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF; KLTH0H15664p 1353305 8294901 KLTH0H15664g Lachancea thermotolerans CBS 6340 KLTH0H15664p XP_002556535.1 1352301 D 559295 CDS KLTH0H15686g 255720512 8294902 complement(join(1353647..1354725,1354841..1355081)) 1 NC_013084.1 similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase; KLTH0H15686p 1355081 8294902 KLTH0H15686g Lachancea thermotolerans CBS 6340 KLTH0H15686p XP_002556536.1 1353647 R 559295 CDS KLTH0H15708g 255720514 8294903 complement(1356162..1357778) 1 NC_013084.1 similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase; KLTH0H15708p 1357778 8294903 KLTH0H15708g Lachancea thermotolerans CBS 6340 KLTH0H15708p XP_002556537.1 1356162 R 559295 CDS KLTH0H15730g 255720516 8294904 1358646..1358834 1 NC_013084.1 highly similar to uniprot|Q3E7B7 Saccharomyces cerevisiae YDL085C-A; KLTH0H15730p 1358834 8294904 KLTH0H15730g Lachancea thermotolerans CBS 6340 KLTH0H15730p XP_002556538.1 1358646 D 559295 CDS KLTH0H15752g 255720518 8294905 complement(1359449..1360501) 1 NC_013084.1 highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation; KLTH0H15752p 1360501 8294905 KLTH0H15752g Lachancea thermotolerans CBS 6340 KLTH0H15752p XP_002556539.1 1359449 R 559295 CDS KLTH0H15774g 255720520 8294906 complement(1360771..1361592) 1 NC_013084.1 similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W; KLTH0H15774p 1361592 8294906 KLTH0H15774g Lachancea thermotolerans CBS 6340 KLTH0H15774p XP_002556540.1 1360771 R 559295 CDS KLTH0H15796g 255720522 8294907 1361913..1362500 1 NC_013084.1 similar to uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF; KLTH0H15796p 1362500 8294907 KLTH0H15796g Lachancea thermotolerans CBS 6340 KLTH0H15796p XP_002556541.1 1361913 D 559295 CDS KLTH0H15818g 255720524 8294908 1362597..1363367 1 NC_013084.1 conserved hypothetical protein; KLTH0H15818p 1363367 8294908 KLTH0H15818g Lachancea thermotolerans CBS 6340 KLTH0H15818p XP_002556542.1 1362597 D 559295 CDS KLTH0H15840g 255720526 8294909 1363510..1363899 1 NC_013084.1 some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W Hypothetical ORF; KLTH0H15840p 1363899 8294909 KLTH0H15840g Lachancea thermotolerans CBS 6340 KLTH0H15840p XP_002556543.1 1363510 D 559295 CDS KLTH0H15862g 255720528 8294910 1364074..1364919 1 NC_013084.1 similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit; KLTH0H15862p 1364919 8294910 KLTH0H15862g Lachancea thermotolerans CBS 6340 KLTH0H15862p XP_002556544.1 1364074 D 559295 CDS KLTH0H15884g 255720530 8294911 complement(1364976..1365566) 1 NC_013084.1 similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial; KLTH0H15884p 1365566 8294911 KLTH0H15884g Lachancea thermotolerans CBS 6340 KLTH0H15884p XP_002556545.1 1364976 R 559295 CDS KLTH0H15906g 255720532 8294912 1365702..1366559 1 NC_013084.1 highly similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site; KLTH0H15906p 1366559 8294912 KLTH0H15906g Lachancea thermotolerans CBS 6340 KLTH0H15906p XP_002556546.1 1365702 D 559295 CDS KLTH0H15928g 255720534 8294913 1367388..1368470 1 NC_013084.1 similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W; KLTH0H15928p 1368470 8294913 KLTH0H15928g Lachancea thermotolerans CBS 6340 KLTH0H15928p XP_002556547.1 1367388 D 559295 CDS KLTH0H15950g 255720536 8294914 1369786..1370871 1 NC_013084.1 similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W; KLTH0H15950p 1370871 8294914 KLTH0H15950g Lachancea thermotolerans CBS 6340 KLTH0H15950p XP_002556548.1 1369786 D 559295 CDS KLTH0H15972g 255720538 8294915 1371189..1372544 1 NC_013084.1 weakly similar to uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p; KLTH0H15972p 1372544 8294915 KLTH0H15972g Lachancea thermotolerans CBS 6340 KLTH0H15972p XP_002556549.1 1371189 D 559295 CDS KLTH0H15994g 255720540 8294916 complement(1372660..1374438) 1 NC_013084.1 weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate; KLTH0H15994p 1374438 8294916 KLTH0H15994g Lachancea thermotolerans CBS 6340 KLTH0H15994p XP_002556550.1 1372660 R 559295 CDS KLTH0H16016g 255720542 8294917 complement(1374529..1376652) 1 NC_013084.1 weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C; KLTH0H16016p 1376652 8294917 KLTH0H16016g Lachancea thermotolerans CBS 6340 KLTH0H16016p XP_002556551.1 1374529 R 559295 CDS KLTH0H16038g 255720544 8294918 1376941..1381890 1 NC_013084.1 similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C; KLTH0H16038p 1381890 8294918 KLTH0H16038g Lachancea thermotolerans CBS 6340 KLTH0H16038p XP_002556552.1 1376941 D 559295 CDS KLTH0H16060g 255720546 8294919 1383120..1384904 1 NC_013084.1 weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Protein required for splicing of COB aI5 intron Cytochrome B pre-mRNA processing protein; KLTH0H16060p 1384904 8294919 KLTH0H16060g Lachancea thermotolerans CBS 6340 KLTH0H16060p XP_002556553.1 1383120 D 559295 CDS KLTH0H16082g 255720548 8294920 complement(1384901..1385512) 1 NC_013084.1 some similarities with uniprot|Q07887 Saccharomyces cerevisiae YLL049W; KLTH0H16082p 1385512 8294920 KLTH0H16082g Lachancea thermotolerans CBS 6340 KLTH0H16082p XP_002556554.1 1384901 R 559295 CDS KLTH0H16104g 255720550 8294921 1385756..1386151 1 NC_013084.1 highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 yeast cortical cytoskeleton component mammalian cofilin homolog Cofilin actin binding and severing protein; KLTH0H16104p 1386151 8294921 KLTH0H16104g Lachancea thermotolerans CBS 6340 KLTH0H16104p XP_002556555.1 1385756 D 559295 CDS KLTH0H16126g 255720552 8294922 complement(1386384..1388099) 1 NC_013084.1 similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF; KLTH0H16126p 1388099 8294922 KLTH0H16126g Lachancea thermotolerans CBS 6340 KLTH0H16126p XP_002556556.1 1386384 R 559295 CDS KLTH0H16148g 255720554 8294923 complement(1388569..1389789) 1 NC_013084.1 some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C; KLTH0H16148p 1389789 8294923 KLTH0H16148g Lachancea thermotolerans CBS 6340 KLTH0H16148p XP_002556557.1 1388569 R 559295 CDS KLTH0H16170g 255720556 8294924 complement(1391996..1393855) 1 NC_013084.1 some similarities with uniprot|P52960 Saccharomyces cerevisiae YOR363C PIP2 peroxisome induction pathway 2 (PIP2) transcriptional activator of peroxisome proliferation may form heterodimer with Oaf1 to activate oleate-inducible gene expression activator of peroxisome proliferation; KLTH0H16170p 1393855 8294924 KLTH0H16170g Lachancea thermotolerans CBS 6340 KLTH0H16170p XP_002556558.1 1391996 R 559295 CDS KLTH0H16192g 255720558 8294925 complement(1394908..1396527) 1 NC_013084.1 weakly similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6; KLTH0H16192p 1396527 8294925 KLTH0H16192g Lachancea thermotolerans CBS 6340 KLTH0H16192p XP_002556559.1 1394908 R 559295 CDS KLTH0H16214g 255720560 8294926 complement(1398230..1399885) 1 NC_013084.1 conserved hypothetical protein; KLTH0H16214p 1399885 8294926 KLTH0H16214g Lachancea thermotolerans CBS 6340 KLTH0H16214p XP_002556560.1 1398230 R 559295 CDS KLTH0H16236g 255720562 8294927 1400457..1402148 1 NC_013084.1 conserved hypothetical protein; KLTH0H16236p 1402148 8294927 KLTH0H16236g Lachancea thermotolerans CBS 6340 KLTH0H16236p XP_002556561.1 1400457 D 559295 CDS KLTH0H16258g 255720564 8294928 1403653..1405455 1 NC_013084.1 similar to uniprot|Q08579 Saccharomyces cerevisiae YOR192C Hypothetical ORF; KLTH0H16258p 1405455 8294928 KLTH0H16258g Lachancea thermotolerans CBS 6340 KLTH0H16258p XP_002556562.1 1403653 D 559295 CDS KLTH0H16390g 255720566 8294934 1409636..1410268 1 NC_013084.1 similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W Hypothetical ORF; KLTH0H16390p 1410268 8294934 KLTH0H16390g Lachancea thermotolerans CBS 6340 KLTH0H16390p XP_002556563.1 1409636 D 559295 CDS KLTH0H16456g 255720568 8294937 1417018..1417812 1 NC_013084.1 conserved hypothetical protein; KLTH0H16456p 1417812 8294937 KLTH0H16456g Lachancea thermotolerans CBS 6340 KLTH0H16456p XP_002556564.1 1417018 D 559295 CDS