-- dump date 20120504_143349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511437000001 Transposase, Mutator family; Region: Transposase_mut; pfam00872 511437000002 MULE transposase domain; Region: MULE; pfam10551 511437000003 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 511437000004 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511437000005 catalytic residues [active] 511437000006 catalytic nucleophile [active] 511437000007 Presynaptic Site I dimer interface [polypeptide binding]; other site 511437000008 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511437000009 Synaptic Flat tetramer interface [polypeptide binding]; other site 511437000010 Synaptic Site I dimer interface [polypeptide binding]; other site 511437000011 DNA binding site [nucleotide binding] 511437000012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437000013 dimerization interface [polypeptide binding]; other site 511437000014 putative DNA binding site [nucleotide binding]; other site 511437000015 putative Zn2+ binding site [ion binding]; other site 511437000016 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 511437000017 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437000018 P loop; other site 511437000019 Nucleotide binding site [chemical binding]; other site 511437000020 DTAP/Switch II; other site 511437000021 Switch I; other site 511437000022 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437000023 DTAP/Switch II; other site 511437000024 Switch I; other site 511437000025 arsenical pump membrane protein; Provisional; Region: PRK15445 511437000026 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 511437000027 transmembrane helices; other site 511437000028 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 511437000029 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000030 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 511437000031 active site 511437000032 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511437000033 DNA topoisomerase III; Provisional; Region: PRK07726 511437000034 active site 511437000035 putative interdomain interaction site [polypeptide binding]; other site 511437000036 putative metal-binding site [ion binding]; other site 511437000037 putative nucleotide binding site [chemical binding]; other site 511437000038 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511437000039 domain I; other site 511437000040 DNA binding groove [nucleotide binding] 511437000041 phosphate binding site [ion binding]; other site 511437000042 domain II; other site 511437000043 domain III; other site 511437000044 nucleotide binding site [chemical binding]; other site 511437000045 catalytic site [active] 511437000046 domain IV; other site 511437000047 MobA/MobL family; Region: MobA_MobL; pfam03389 511437000048 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 511437000049 Helix-turn-helix domains; Region: HTH; cl00088 511437000050 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437000051 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437000052 Magnesium ion binding site [ion binding]; other site 511437000053 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000054 Helix-turn-helix domains; Region: HTH; cl00088 511437000055 Integrase core domain; Region: rve; cl01316 511437000056 Helix-turn-helix domains; Region: HTH; cl00088 511437000057 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000058 Integrase core domain; Region: rve; cl01316 511437000059 Integrase core domain; Region: rve_3; cl15866 511437000060 Helix-turn-helix domains; Region: HTH; cl00088 511437000061 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437000062 ArsC family; Region: ArsC; pfam03960 511437000063 putative catalytic residues [active] 511437000064 thiol/disulfide switch; other site 511437000065 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000066 Helix-turn-helix domains; Region: HTH; cl00088 511437000067 Integrase core domain; Region: rve; cl01316 511437000068 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000069 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437000070 substrate binding site [chemical binding]; other site 511437000071 dimer interface [polypeptide binding]; other site 511437000072 ATP binding site [chemical binding]; other site 511437000073 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 511437000074 active site 511437000075 catalytic residues [active] 511437000076 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511437000077 intersubunit interface [polypeptide binding]; other site 511437000078 active site 511437000079 catalytic residue [active] 511437000080 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 511437000081 Helix-turn-helix domains; Region: HTH; cl00088 511437000082 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511437000083 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 511437000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000085 putative substrate translocation pore; other site 511437000086 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 511437000087 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000088 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437000089 substrate binding site [chemical binding]; other site 511437000090 dimer interface [polypeptide binding]; other site 511437000091 ATP binding site [chemical binding]; other site 511437000092 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511437000093 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000094 active site 511437000095 dimer interface [polypeptide binding]; other site 511437000096 Transposase domain (DUF772); Region: DUF772; cl15789 511437000097 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000098 Transposase domain (DUF772); Region: DUF772; cl15789 511437000099 Core-2/I-Branching enzyme; Region: Branch; pfam02485 511437000100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437000101 active site 511437000102 HIGH motif; other site 511437000103 nucleotide binding site [chemical binding]; other site 511437000104 Transposase domain (DUF772); Region: DUF772; cl15789 511437000105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000106 Transposase domain (DUF772); Region: DUF772; cl15789 511437000107 Transposase, Mutator family; Region: Transposase_mut; pfam00872 511437000108 MULE transposase domain; Region: MULE; pfam10551 511437000109 putative glycosyl transferase; Provisional; Region: PRK10073 511437000110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511437000111 active site 511437000112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437000113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511437000114 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437000115 active site 511437000116 Bacterial sugar transferase; Region: Bac_transf; cl00939 511437000117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000118 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 511437000119 NAD(P) binding site [chemical binding]; other site 511437000120 active site 511437000121 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 511437000122 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 511437000123 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437000124 Nucleotide binding site [chemical binding]; other site 511437000125 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 511437000126 Chain length determinant protein; Region: Wzz; cl15801 511437000127 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 511437000128 Helix-turn-helix domains; Region: HTH; cl00088 511437000129 Transposase domain (DUF772); Region: DUF772; cl15789 511437000130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000131 Transposase domain (DUF772); Region: DUF772; cl15789 511437000132 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 511437000133 Int/Topo IB signature motif; other site 511437000134 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 511437000135 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 511437000136 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000137 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 511437000138 active site 511437000139 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000140 Helix-turn-helix domains; Region: HTH; cl00088 511437000141 Integrase core domain; Region: rve; cl01316 511437000142 Transposase domain (DUF772); Region: DUF772; cl15789 511437000143 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000144 Transposase domain (DUF772); Region: DUF772; cl15789 511437000145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437000146 dimerization interface [polypeptide binding]; other site 511437000147 putative DNA binding site [nucleotide binding]; other site 511437000148 putative Zn2+ binding site [ion binding]; other site 511437000149 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 511437000150 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511437000151 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511437000152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437000153 Walker A motif; other site 511437000154 ATP binding site [chemical binding]; other site 511437000155 Walker B motif; other site 511437000156 arginine finger; other site 511437000157 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511437000158 DnaA box-binding interface [nucleotide binding]; other site 511437000159 DNA polymerase III subunit beta; Validated; Region: PRK05643 511437000160 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511437000161 putative DNA binding surface [nucleotide binding]; other site 511437000162 dimer interface [polypeptide binding]; other site 511437000163 beta-clamp/clamp loader binding surface; other site 511437000164 beta-clamp/translesion DNA polymerase binding surface; other site 511437000165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 511437000166 recombination protein F; Reviewed; Region: recF; PRK00064 511437000167 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 511437000168 Walker A/P-loop; other site 511437000169 ATP binding site [chemical binding]; other site 511437000170 Q-loop/lid; other site 511437000171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000172 ABC transporter signature motif; other site 511437000173 Walker B; other site 511437000174 D-loop; other site 511437000175 H-loop/switch region; other site 511437000176 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511437000177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437000178 Mg2+ binding site [ion binding]; other site 511437000179 G-X-G motif; other site 511437000180 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511437000181 anchoring element; other site 511437000182 dimer interface [polypeptide binding]; other site 511437000183 ATP binding site [chemical binding]; other site 511437000184 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511437000185 active site 511437000186 putative metal-binding site [ion binding]; other site 511437000187 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511437000188 DNA gyrase subunit A; Validated; Region: PRK05560 511437000189 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 511437000190 CAP-like domain; other site 511437000191 active site 511437000192 primary dimer interface [polypeptide binding]; other site 511437000193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000195 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000197 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000198 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437000199 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 511437000200 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 511437000201 active site 511437000202 teramer interface [polypeptide binding]; other site 511437000203 FMN binding site [chemical binding]; other site 511437000204 catalytic residues [active] 511437000205 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 511437000206 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511437000207 dimer interface [polypeptide binding]; other site 511437000208 ssDNA binding site [nucleotide binding]; other site 511437000209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000210 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 511437000211 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 511437000212 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437000213 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 511437000214 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 511437000215 DHH family; Region: DHH; pfam01368 511437000216 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511437000217 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511437000218 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511437000219 replicative DNA helicase; Provisional; Region: PRK05748 511437000220 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511437000221 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511437000222 Walker A motif; other site 511437000223 ATP binding site [chemical binding]; other site 511437000224 Walker B motif; other site 511437000225 DNA binding loops [nucleotide binding] 511437000226 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437000227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437000228 Helix-turn-helix domains; Region: HTH; cl00088 511437000229 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 511437000230 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511437000231 Int/Topo IB signature motif; other site 511437000232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437000233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437000234 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 511437000235 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 511437000236 Transposase domain (DUF772); Region: DUF772; cl15789 511437000237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000238 Transposase domain (DUF772); Region: DUF772; cl15789 511437000239 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 511437000240 polymerase nucleotide-binding site; other site 511437000241 DNA-binding residues [nucleotide binding]; DNA binding site 511437000242 nucleotide binding site [chemical binding]; other site 511437000243 primase nucleotide-binding site [nucleotide binding]; other site 511437000244 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 511437000245 D5 N terminal like; Region: D5_N; cl07360 511437000246 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 511437000247 Helix-turn-helix domains; Region: HTH; cl00088 511437000248 Integrase core domain; Region: rve; cl01316 511437000249 Integrase core domain; Region: rve; cl01316 511437000250 DDE domain; Region: DDE_Tnp_IS240; pfam13610 511437000251 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000252 Helix-turn-helix domains; Region: HTH; cl00088 511437000253 Integrase core domain; Region: rve; cl01316 511437000254 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 511437000255 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 511437000256 GIY-YIG motif/motif A; other site 511437000257 putative active site [active] 511437000258 putative metal binding site [ion binding]; other site 511437000259 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000260 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 511437000261 Uncharacterized conserved protein [Function unknown]; Region: COG3410 511437000262 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000263 Helix-turn-helix domains; Region: HTH; cl00088 511437000264 Integrase core domain; Region: rve; cl01316 511437000265 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 511437000266 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 511437000267 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 511437000268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437000269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437000270 active site 511437000271 phosphorylation site [posttranslational modification] 511437000272 intermolecular recognition site; other site 511437000273 dimerization interface [polypeptide binding]; other site 511437000274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437000275 DNA binding site [nucleotide binding] 511437000276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 511437000277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511437000278 dimerization interface [polypeptide binding]; other site 511437000279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511437000280 putative active site [active] 511437000281 heme pocket [chemical binding]; other site 511437000282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437000283 dimer interface [polypeptide binding]; other site 511437000284 phosphorylation site [posttranslational modification] 511437000285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437000286 ATP binding site [chemical binding]; other site 511437000287 Mg2+ binding site [ion binding]; other site 511437000288 G-X-G motif; other site 511437000289 YycH protein; Region: YycH; pfam07435 511437000290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 511437000291 YycH protein; Region: YycI; cl02015 511437000292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437000293 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 511437000294 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511437000295 protein binding site [polypeptide binding]; other site 511437000296 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 511437000297 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 511437000298 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437000299 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 511437000300 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437000301 Helix-turn-helix domains; Region: HTH; cl00088 511437000302 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511437000303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000304 Helix-turn-helix domains; Region: HTH; cl00088 511437000305 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 511437000306 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437000307 classical (c) SDRs; Region: SDR_c; cd05233 511437000308 NAD(P) binding site [chemical binding]; other site 511437000309 active site 511437000310 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437000311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437000312 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000313 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000314 peptide binding site [polypeptide binding]; other site 511437000315 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511437000316 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511437000317 oligomer interface [polypeptide binding]; other site 511437000318 active site 511437000319 metal binding site [ion binding]; metal-binding site 511437000320 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 511437000321 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000322 catalytic triad [active] 511437000323 putative alpha-glucosidase; Provisional; Region: PRK10658 511437000324 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 511437000325 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 511437000326 trimer interface [polypeptide binding]; other site 511437000327 active site 511437000328 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 511437000329 catalytic site [active] 511437000330 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000331 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 511437000332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000333 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437000334 formate dehydrogenase; Provisional; Region: PRK07574 511437000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000336 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 511437000337 acetolactate synthase; Reviewed; Region: PRK08617 511437000338 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511437000339 PYR/PP interface [polypeptide binding]; other site 511437000340 dimer interface [polypeptide binding]; other site 511437000341 TPP binding site [chemical binding]; other site 511437000342 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 511437000343 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511437000344 TPP-binding site [chemical binding]; other site 511437000345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437000346 Helix-turn-helix domains; Region: HTH; cl00088 511437000347 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 511437000348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 511437000349 tetrameric interface [polypeptide binding]; other site 511437000350 activator binding site; other site 511437000351 NADP binding site [chemical binding]; other site 511437000352 substrate binding site [chemical binding]; other site 511437000353 catalytic residues [active] 511437000354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000355 acetoin reductases; Region: 23BDH; TIGR02415 511437000356 NAD(P) binding site [chemical binding]; other site 511437000357 active site 511437000358 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 511437000359 Transcriptional regulator [Transcription]; Region: IclR; COG1414 511437000360 Helix-turn-helix domains; Region: HTH; cl00088 511437000361 Bacterial transcriptional regulator; Region: IclR; pfam01614 511437000362 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 511437000363 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511437000364 NADP binding site [chemical binding]; other site 511437000365 homodimer interface [polypeptide binding]; other site 511437000366 active site 511437000367 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511437000368 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437000369 substrate binding site [chemical binding]; other site 511437000370 ATP binding site [chemical binding]; other site 511437000371 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 511437000372 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 511437000373 active site 511437000374 intersubunit interface [polypeptide binding]; other site 511437000375 catalytic residue [active] 511437000376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000378 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437000379 peptidase domain interface [polypeptide binding]; other site 511437000380 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511437000381 active site 511437000382 catalytic residues [active] 511437000383 SH3-like domain; Region: SH3_8; pfam13457 511437000384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437000385 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437000386 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 511437000387 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 511437000388 AMP-binding enzyme; Region: AMP-binding; cl15778 511437000389 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 511437000390 Phosphopantetheine attachment site; Region: PP-binding; cl09936 511437000391 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 511437000392 DltD N-terminal region; Region: DltD_N; pfam04915 511437000393 DltD central region; Region: DltD_M; pfam04918 511437000394 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 511437000395 SH3-like domain; Region: SH3_8; pfam13457 511437000396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437000397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437000398 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511437000399 Walker A/P-loop; other site 511437000400 ATP binding site [chemical binding]; other site 511437000401 Q-loop/lid; other site 511437000402 ABC transporter signature motif; other site 511437000403 Walker B; other site 511437000404 D-loop; other site 511437000405 H-loop/switch region; other site 511437000406 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 511437000407 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 511437000408 NADP binding site [chemical binding]; other site 511437000409 CrcB-like protein; Region: CRCB; cl09114 511437000410 CrcB-like protein; Region: CRCB; cl09114 511437000411 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511437000412 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 511437000413 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 511437000414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511437000415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437000416 catalytic residue [active] 511437000417 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511437000418 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437000419 HIGH motif; other site 511437000420 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437000421 active site 511437000422 KMSKS motif; other site 511437000423 Protein of unknown function (DUF436); Region: DUF436; cl01860 511437000424 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511437000425 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 511437000426 OsmC-like protein; Region: OsmC; cl00767 511437000427 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000428 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000429 peptide binding site [polypeptide binding]; other site 511437000430 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511437000431 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511437000432 Ca binding site [ion binding]; other site 511437000433 active site 511437000434 catalytic site [active] 511437000435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000436 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 511437000437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437000439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000440 DNA binding site [nucleotide binding] 511437000441 domain linker motif; other site 511437000442 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437000443 dimerization interface [polypeptide binding]; other site 511437000444 ligand binding site [chemical binding]; other site 511437000445 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437000446 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437000447 catalytic Zn binding site [ion binding]; other site 511437000448 NAD binding site [chemical binding]; other site 511437000449 structural Zn binding site [ion binding]; other site 511437000450 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 511437000451 putative uracil binding site [chemical binding]; other site 511437000452 putative active site [active] 511437000453 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437000454 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 511437000455 active site 511437000456 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 511437000457 active site 511437000458 dimerization interface [polypeptide binding]; other site 511437000459 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 511437000460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000461 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437000462 Sugar fermentation stimulation protein; Region: SfsA; cl00647 511437000463 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437000464 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437000465 active site 511437000466 catalytic site [active] 511437000467 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437000468 peptidase domain interface [polypeptide binding]; other site 511437000469 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437000470 active site 511437000471 catalytic triad [active] 511437000472 calcium binding site [ion binding]; other site 511437000473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437000474 sequence-specific DNA binding site [nucleotide binding]; other site 511437000475 salt bridge; other site 511437000476 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511437000477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000478 Walker A/P-loop; other site 511437000479 ATP binding site [chemical binding]; other site 511437000480 Q-loop/lid; other site 511437000481 ABC transporter signature motif; other site 511437000482 Walker B; other site 511437000483 D-loop; other site 511437000484 H-loop/switch region; other site 511437000485 TOBE domain; Region: TOBE_2; cl01440 511437000486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000487 dimer interface [polypeptide binding]; other site 511437000488 conserved gate region; other site 511437000489 putative PBP binding loops; other site 511437000490 ABC-ATPase subunit interface; other site 511437000491 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511437000492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000493 dimer interface [polypeptide binding]; other site 511437000494 conserved gate region; other site 511437000495 putative PBP binding loops; other site 511437000496 ABC-ATPase subunit interface; other site 511437000497 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511437000498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437000499 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437000500 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437000501 active site 511437000502 catalytic site [active] 511437000503 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000504 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000505 peptide binding site [polypeptide binding]; other site 511437000506 Ferrochelatase; Region: Ferrochelatase; pfam00762 511437000507 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 511437000508 C-terminal domain interface [polypeptide binding]; other site 511437000509 active site 511437000510 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 511437000511 active site 511437000512 N-terminal domain interface [polypeptide binding]; other site 511437000513 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 511437000514 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437000515 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437000516 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 511437000517 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437000518 CAAX protease self-immunity; Region: Abi; cl00558 511437000519 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437000520 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437000521 DNA binding residues [nucleotide binding] 511437000522 putative dimer interface [polypeptide binding]; other site 511437000523 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 511437000524 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000525 active site 511437000526 catalytic tetrad [active] 511437000527 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437000528 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 511437000529 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 511437000530 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511437000531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437000532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437000533 DNA binding residues [nucleotide binding] 511437000534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 511437000535 Phosphotransferase enzyme family; Region: APH; pfam01636 511437000536 active site 511437000537 substrate binding site [chemical binding]; other site 511437000538 ATP binding site [chemical binding]; other site 511437000539 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 511437000540 putative active site [active] 511437000541 putative FMN binding site [chemical binding]; other site 511437000542 putative substrate binding site [chemical binding]; other site 511437000543 putative catalytic residue [active] 511437000544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000545 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 511437000546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000547 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 511437000548 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000549 active site 511437000550 catalytic tetrad [active] 511437000551 Ferritin-like domain; Region: Ferritin; pfam00210 511437000552 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 511437000553 dimerization interface [polypeptide binding]; other site 511437000554 DPS ferroxidase diiron center [ion binding]; other site 511437000555 ion pore; other site 511437000556 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 511437000557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000558 putative substrate translocation pore; other site 511437000559 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 511437000560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437000561 active site 511437000562 motif I; other site 511437000563 motif II; other site 511437000564 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 511437000565 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511437000566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000567 putative substrate translocation pore; other site 511437000568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000569 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 511437000570 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 511437000571 potential catalytic triad [active] 511437000572 conserved cys residue [active] 511437000573 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511437000574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000575 Walker A/P-loop; other site 511437000576 ATP binding site [chemical binding]; other site 511437000577 Q-loop/lid; other site 511437000578 ABC transporter signature motif; other site 511437000579 Walker B; other site 511437000580 D-loop; other site 511437000581 H-loop/switch region; other site 511437000582 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437000583 N-glycosyltransferase; Provisional; Region: PRK11204 511437000584 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511437000585 DXD motif; other site 511437000586 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 511437000587 putative active site [active] 511437000588 putative metal binding site [ion binding]; other site 511437000589 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 511437000590 Helix-turn-helix domains; Region: HTH; cl00088 511437000591 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000592 Integrase core domain; Region: rve; cl01316 511437000593 Integrase core domain; Region: rve_3; cl15866 511437000594 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437000595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437000596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437000597 homodimer interface [polypeptide binding]; other site 511437000598 catalytic residue [active] 511437000599 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511437000600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000601 putative substrate translocation pore; other site 511437000602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000603 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511437000604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000605 glutamate dehydrogenase; Provisional; Region: PRK09414 511437000606 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 511437000607 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511437000608 NAD(P) binding site [chemical binding]; other site 511437000609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437000610 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437000611 substrate binding pocket [chemical binding]; other site 511437000612 membrane-bound complex binding site; other site 511437000613 hinge residues; other site 511437000614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000615 dimer interface [polypeptide binding]; other site 511437000616 conserved gate region; other site 511437000617 putative PBP binding loops; other site 511437000618 ABC-ATPase subunit interface; other site 511437000619 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511437000620 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 511437000621 metal binding site [ion binding]; metal-binding site 511437000622 LemA family; Region: LemA; cl00742 511437000623 Peptidase family M48; Region: Peptidase_M48; cl12018 511437000624 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 511437000625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437000626 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437000627 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 511437000628 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 511437000629 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 511437000630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000631 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437000632 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 511437000633 Prephenate dehydratase; Region: PDT; pfam00800 511437000634 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437000635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437000636 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511437000637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437000638 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 511437000639 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 511437000640 NADP binding site [chemical binding]; other site 511437000641 substrate binding site [chemical binding]; other site 511437000642 active site 511437000643 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 511437000644 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 511437000645 Helix-turn-helix domains; Region: HTH; cl00088 511437000646 glyoxylate reductase; Reviewed; Region: PRK13243 511437000647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000648 Helix-turn-helix domains; Region: HTH; cl00088 511437000649 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000650 Integrase core domain; Region: rve; cl01316 511437000651 Integrase core domain; Region: rve_3; cl15866 511437000652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437000653 non-specific DNA binding site [nucleotide binding]; other site 511437000654 salt bridge; other site 511437000655 sequence-specific DNA binding site [nucleotide binding]; other site 511437000656 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 511437000657 Isochorismatase family; Region: Isochorismatase; pfam00857 511437000658 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 511437000659 catalytic triad [active] 511437000660 dimer interface [polypeptide binding]; other site 511437000661 conserved cis-peptide bond; other site 511437000662 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437000663 amidase catalytic site [active] 511437000664 Zn binding residues [ion binding]; other site 511437000665 substrate binding site [chemical binding]; other site 511437000666 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 511437000667 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 511437000668 metal binding site [ion binding]; metal-binding site 511437000669 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437000670 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437000671 active site 511437000672 Cupin domain; Region: Cupin_2; cl09118 511437000673 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511437000674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437000676 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437000677 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 511437000679 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 511437000680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000681 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000682 putative substrate translocation pore; other site 511437000683 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 511437000684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000685 DNA binding site [nucleotide binding] 511437000686 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511437000687 putative dimerization interface [polypeptide binding]; other site 511437000688 putative ligand binding site [chemical binding]; other site 511437000689 beta-D-glucuronidase; Provisional; Region: PRK10150 511437000690 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 511437000691 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437000692 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 511437000693 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 511437000694 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 511437000695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437000696 Coenzyme A binding pocket [chemical binding]; other site 511437000697 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 511437000698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000699 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000700 Peptidase C26; Region: Peptidase_C26; pfam07722 511437000701 catalytic triad [active] 511437000702 EamA-like transporter family; Region: EamA; cl01037 511437000703 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511437000704 EamA-like transporter family; Region: EamA; cl01037 511437000705 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 511437000706 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 511437000707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000708 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437000709 NAD(P) binding site [chemical binding]; other site 511437000710 active site 511437000711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000712 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437000713 active site 511437000714 catalytic tetrad [active] 511437000715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437000716 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437000717 DNA binding residues [nucleotide binding] 511437000718 putative dimer interface [polypeptide binding]; other site 511437000719 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437000720 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 511437000721 active site 511437000722 Peptidase C26; Region: Peptidase_C26; pfam07722 511437000723 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511437000724 catalytic triad [active] 511437000725 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 511437000726 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 511437000727 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437000728 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000729 Walker A/P-loop; other site 511437000730 ATP binding site [chemical binding]; other site 511437000731 Q-loop/lid; other site 511437000732 ABC transporter signature motif; other site 511437000733 Walker B; other site 511437000734 D-loop; other site 511437000735 H-loop/switch region; other site 511437000736 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437000737 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437000738 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 511437000739 Walker A/P-loop; other site 511437000740 ATP binding site [chemical binding]; other site 511437000741 Q-loop/lid; other site 511437000742 ABC transporter signature motif; other site 511437000743 Walker B; other site 511437000744 D-loop; other site 511437000745 H-loop/switch region; other site 511437000746 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511437000747 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 511437000748 putative dimer interface [polypeptide binding]; other site 511437000749 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511437000750 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 511437000751 putative dimer interface [polypeptide binding]; other site 511437000752 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 511437000753 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 511437000754 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 511437000755 dimer interface [polypeptide binding]; other site 511437000756 FMN binding site [chemical binding]; other site 511437000757 NADPH bind site [chemical binding]; other site 511437000758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000759 dimer interface [polypeptide binding]; other site 511437000760 conserved gate region; other site 511437000761 putative PBP binding loops; other site 511437000762 ABC-ATPase subunit interface; other site 511437000763 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437000764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437000765 dimer interface [polypeptide binding]; other site 511437000766 conserved gate region; other site 511437000767 putative PBP binding loops; other site 511437000768 ABC-ATPase subunit interface; other site 511437000769 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437000770 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 511437000771 Walker A/P-loop; other site 511437000772 ATP binding site [chemical binding]; other site 511437000773 Q-loop/lid; other site 511437000774 ABC transporter signature motif; other site 511437000775 Walker B; other site 511437000776 D-loop; other site 511437000777 H-loop/switch region; other site 511437000778 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 511437000779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437000780 substrate binding pocket [chemical binding]; other site 511437000781 membrane-bound complex binding site; other site 511437000782 hinge residues; other site 511437000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000784 putative substrate translocation pore; other site 511437000785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000786 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 511437000787 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 511437000788 active site 511437000789 catalytic residue [active] 511437000790 dimer interface [polypeptide binding]; other site 511437000791 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511437000792 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000793 peptide binding site [polypeptide binding]; other site 511437000794 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437000795 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437000796 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511437000797 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 511437000798 active site 511437000799 Chorismate mutase type II; Region: CM_2; cl00693 511437000800 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 511437000801 Tetramer interface [polypeptide binding]; other site 511437000802 active site 511437000803 FMN-binding site [chemical binding]; other site 511437000804 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 511437000805 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 511437000806 hinge; other site 511437000807 active site 511437000808 Prephenate dehydrogenase; Region: PDH; pfam02153 511437000809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000810 shikimate kinase; Reviewed; Region: aroK; PRK00131 511437000811 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511437000812 ADP binding site [chemical binding]; other site 511437000813 magnesium binding site [ion binding]; other site 511437000814 putative shikimate binding site; other site 511437000815 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 511437000816 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511437000817 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511437000818 shikimate binding site; other site 511437000819 NAD(P) binding site [chemical binding]; other site 511437000820 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437000821 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 511437000822 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437000823 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437000824 DNA binding site [nucleotide binding] 511437000825 domain linker motif; other site 511437000826 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511437000827 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437000828 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437000829 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 511437000830 HPr interaction site; other site 511437000831 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511437000832 active site 511437000833 phosphorylation site [posttranslational modification] 511437000834 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 511437000835 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 511437000836 catalytic site [active] 511437000837 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 511437000838 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437000839 active site 511437000840 substrate binding site [chemical binding]; other site 511437000841 trimer interface [polypeptide binding]; other site 511437000842 CoA binding site [chemical binding]; other site 511437000843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437000844 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437000845 putative substrate translocation pore; other site 511437000846 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437000847 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 511437000848 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 511437000849 NlpC/P60 family; Region: NLPC_P60; cl11438 511437000850 PemK-like protein; Region: PemK; cl00995 511437000851 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000852 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437000853 Catalytic site [active] 511437000854 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 511437000855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437000856 PemK-like protein; Region: PemK; cl00995 511437000857 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437000858 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 511437000859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437000860 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437000861 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511437000862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437000863 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437000864 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511437000865 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 511437000866 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511437000867 catalytic site [active] 511437000868 subunit interface [polypeptide binding]; other site 511437000869 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 511437000870 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437000871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000872 dihydroorotase; Validated; Region: pyrC; PRK09357 511437000873 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437000874 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 511437000875 active site 511437000876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000877 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000878 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 511437000879 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511437000880 dimer interface [polypeptide binding]; other site 511437000881 active site 511437000882 ADP-ribose binding site [chemical binding]; other site 511437000883 nudix motif; other site 511437000884 metal binding site [ion binding]; metal-binding site 511437000885 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 511437000886 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 511437000887 YcfA-like protein; Region: YcfA; cl00752 511437000888 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 511437000889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000890 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 511437000891 L-serine binding site [chemical binding]; other site 511437000892 ACT domain interface; other site 511437000893 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511437000894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437000895 catalytic residue [active] 511437000896 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437000897 catalytic core [active] 511437000898 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437000899 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437000900 peptide binding site [polypeptide binding]; other site 511437000901 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 511437000902 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437000903 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 511437000904 NAD binding site [chemical binding]; other site 511437000905 dimer interface [polypeptide binding]; other site 511437000906 substrate binding site [chemical binding]; other site 511437000907 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437000908 UbiA prenyltransferase family; Region: UbiA; cl00337 511437000909 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 511437000910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437000911 S-adenosylmethionine binding site [chemical binding]; other site 511437000912 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437000913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437000914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437000915 homodimer interface [polypeptide binding]; other site 511437000916 catalytic residue [active] 511437000917 D-lactate dehydrogenase; Validated; Region: PRK08605 511437000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000919 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 511437000920 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 511437000921 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437000922 Helix-turn-helix domains; Region: HTH; cl00088 511437000923 Integrase core domain; Region: rve; cl01316 511437000924 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 511437000925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437000926 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437000927 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 511437000928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437000929 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437000930 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511437000931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437000932 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437000933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437000934 Walker A/P-loop; other site 511437000935 ATP binding site [chemical binding]; other site 511437000936 Q-loop/lid; other site 511437000937 ABC transporter signature motif; other site 511437000938 H-loop/switch region; other site 511437000939 Transposase domain (DUF772); Region: DUF772; cl15789 511437000940 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437000941 Transposase domain (DUF772); Region: DUF772; cl15789 511437000942 Abi-like protein; Region: Abi_2; cl01988 511437000943 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 511437000944 catalytic residues [active] 511437000945 dimer interface [polypeptide binding]; other site 511437000946 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437000947 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511437000948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437000949 Helix-turn-helix domains; Region: HTH; cl00088 511437000950 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 511437000951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511437000952 FtsX-like permease family; Region: FtsX; cl15850 511437000953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437000954 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511437000955 Walker A/P-loop; other site 511437000956 ATP binding site [chemical binding]; other site 511437000957 Q-loop/lid; other site 511437000958 ABC transporter signature motif; other site 511437000959 Walker B; other site 511437000960 D-loop; other site 511437000961 H-loop/switch region; other site 511437000962 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511437000963 CoenzymeA binding site [chemical binding]; other site 511437000964 subunit interaction site [polypeptide binding]; other site 511437000965 PHB binding site; other site 511437000966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511437000967 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 511437000968 substrate binding site [chemical binding]; other site 511437000969 oxyanion hole (OAH) forming residues; other site 511437000970 trimer interface [polypeptide binding]; other site 511437000971 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 511437000972 AMP-binding enzyme; Region: AMP-binding; cl15778 511437000973 putrescine carbamoyltransferase; Provisional; Region: PRK02255 511437000974 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437000975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437000976 Spore germination protein; Region: Spore_permease; cl15802 511437000977 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 511437000978 agmatine deiminase; Region: agmatine_aguA; TIGR03380 511437000979 carbamate kinase; Reviewed; Region: PRK12686 511437000980 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511437000981 putative substrate binding site [chemical binding]; other site 511437000982 nucleotide binding site [chemical binding]; other site 511437000983 nucleotide binding site [chemical binding]; other site 511437000984 homodimer interface [polypeptide binding]; other site 511437000985 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 511437000986 agmatine deiminase; Region: agmatine_aguA; TIGR03380 511437000987 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 511437000988 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511437000989 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511437000990 putative active site [active] 511437000991 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 511437000992 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 511437000993 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437000994 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 511437000995 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437000996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437000997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437000998 active site 511437000999 catalytic tetrad [active] 511437001000 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 511437001001 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 511437001002 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437001003 polyphosphate kinase; Provisional; Region: PRK05443 511437001004 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 511437001005 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 511437001006 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 511437001007 putative domain interface [polypeptide binding]; other site 511437001008 putative active site [active] 511437001009 catalytic site [active] 511437001010 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 511437001011 putative domain interface [polypeptide binding]; other site 511437001012 putative active site [active] 511437001013 catalytic site [active] 511437001014 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 511437001015 VanZ like family; Region: VanZ; cl01971 511437001016 RDD family; Region: RDD; cl00746 511437001017 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511437001018 putative active site [active] 511437001019 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001020 ArsC family; Region: ArsC; pfam03960 511437001021 putative catalytic residues [active] 511437001022 thiol/disulfide switch; other site 511437001023 transaminase; Validated; Region: PRK07324 511437001024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437001025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001026 homodimer interface [polypeptide binding]; other site 511437001027 catalytic residue [active] 511437001028 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 511437001029 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 511437001030 FAD binding site [chemical binding]; other site 511437001031 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 511437001032 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 511437001033 THF binding site; other site 511437001034 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437001035 substrate binding site [chemical binding]; other site 511437001036 THF binding site; other site 511437001037 zinc-binding site [ion binding]; other site 511437001038 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 511437001039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001040 Helix-turn-helix domains; Region: HTH; cl00088 511437001041 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511437001042 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437001043 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511437001044 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511437001045 Walker A/P-loop; other site 511437001046 ATP binding site [chemical binding]; other site 511437001047 Q-loop/lid; other site 511437001048 ABC transporter signature motif; other site 511437001049 Walker B; other site 511437001050 D-loop; other site 511437001051 H-loop/switch region; other site 511437001052 Sodium:solute symporter family; Region: SSF; cl00456 511437001053 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511437001054 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 511437001055 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 511437001056 Cobalt transport protein; Region: CbiQ; cl00463 511437001057 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437001058 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001059 Walker A/P-loop; other site 511437001060 ATP binding site [chemical binding]; other site 511437001061 Q-loop/lid; other site 511437001062 ABC transporter signature motif; other site 511437001063 Walker B; other site 511437001064 D-loop; other site 511437001065 H-loop/switch region; other site 511437001066 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437001067 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001068 Walker A/P-loop; other site 511437001069 ATP binding site [chemical binding]; other site 511437001070 Q-loop/lid; other site 511437001071 ABC transporter signature motif; other site 511437001072 Walker B; other site 511437001073 D-loop; other site 511437001074 H-loop/switch region; other site 511437001075 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511437001076 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437001077 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 511437001078 Ligand binding site [chemical binding]; other site 511437001079 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511437001080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511437001081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511437001082 active site 511437001083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001084 non-specific DNA binding site [nucleotide binding]; other site 511437001085 salt bridge; other site 511437001086 sequence-specific DNA binding site [nucleotide binding]; other site 511437001087 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 511437001088 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 511437001089 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437001090 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437001091 Helix-turn-helix domains; Region: HTH; cl00088 511437001092 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 511437001093 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437001094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437001095 Ligand Binding Site [chemical binding]; other site 511437001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001098 putative substrate translocation pore; other site 511437001099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 511437001101 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 511437001102 NAD(P) binding site [chemical binding]; other site 511437001103 catalytic residues [active] 511437001104 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511437001105 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511437001106 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 511437001107 putative active site [active] 511437001108 nucleotide binding site [chemical binding]; other site 511437001109 nudix motif; other site 511437001110 putative metal binding site [ion binding]; other site 511437001111 Helix-turn-helix domains; Region: HTH; cl00088 511437001112 intracellular protease, PfpI family; Region: PfpI; TIGR01382 511437001113 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 511437001114 proposed catalytic triad [active] 511437001115 conserved cys residue [active] 511437001116 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 511437001117 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 511437001118 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437001119 NAD(P) binding site [chemical binding]; other site 511437001120 putative active site [active] 511437001121 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511437001122 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437001123 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437001124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511437001125 metal-binding site [ion binding] 511437001126 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511437001127 Ferritin-like domain; Region: Ferritin; pfam00210 511437001128 dinuclear metal binding motif [ion binding]; other site 511437001129 AIR carboxylase; Region: AIRC; cl00310 511437001130 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 511437001131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001132 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437001133 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 511437001134 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 511437001135 ATP binding site [chemical binding]; other site 511437001136 active site 511437001137 substrate binding site [chemical binding]; other site 511437001138 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 511437001139 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 511437001140 putative active site [active] 511437001141 catalytic triad [active] 511437001142 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 511437001143 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 511437001144 dimerization interface [polypeptide binding]; other site 511437001145 ATP binding site [chemical binding]; other site 511437001146 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 511437001147 dimerization interface [polypeptide binding]; other site 511437001148 ATP binding site [chemical binding]; other site 511437001149 amidophosphoribosyltransferase; Provisional; Region: PRK07272 511437001150 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 511437001151 active site 511437001152 tetramer interface [polypeptide binding]; other site 511437001153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437001154 active site 511437001155 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 511437001156 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 511437001157 dimerization interface [polypeptide binding]; other site 511437001158 putative ATP binding site [chemical binding]; other site 511437001159 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 511437001160 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 511437001161 active site 511437001162 substrate binding site [chemical binding]; other site 511437001163 cosubstrate binding site; other site 511437001164 catalytic site [active] 511437001165 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 511437001166 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 511437001167 purine monophosphate binding site [chemical binding]; other site 511437001168 dimer interface [polypeptide binding]; other site 511437001169 putative catalytic residues [active] 511437001170 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 511437001171 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 511437001172 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 511437001173 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 511437001174 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437001175 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 511437001176 Protein of unknown function (DUF328); Region: DUF328; cl01143 511437001177 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 511437001178 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001179 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437001180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001181 active site 511437001182 motif I; other site 511437001183 motif II; other site 511437001184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001185 benzoate transport; Region: 2A0115; TIGR00895 511437001186 putative substrate translocation pore; other site 511437001187 PemK-like protein; Region: PemK; cl00995 511437001188 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 511437001189 active site 511437001190 dimer interface [polypeptide binding]; other site 511437001191 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 511437001192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437001193 active site 511437001194 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 511437001195 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 511437001196 active site 511437001197 FMN binding site [chemical binding]; other site 511437001198 substrate binding site [chemical binding]; other site 511437001199 catalytic residues [active] 511437001200 homodimer interface [polypeptide binding]; other site 511437001201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001202 Walker A/P-loop; other site 511437001203 ATP binding site [chemical binding]; other site 511437001204 Q-loop/lid; other site 511437001205 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001206 ABC transporter signature motif; other site 511437001207 Walker B; other site 511437001208 D-loop; other site 511437001209 H-loop/switch region; other site 511437001210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001211 AAA domain; Region: AAA_21; pfam13304 511437001212 Walker A/P-loop; other site 511437001213 ATP binding site [chemical binding]; other site 511437001214 Q-loop/lid; other site 511437001215 ABC transporter signature motif; other site 511437001216 Walker B; other site 511437001217 D-loop; other site 511437001218 H-loop/switch region; other site 511437001219 Helix-turn-helix domains; Region: HTH; cl00088 511437001220 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511437001221 Cupin domain; Region: Cupin_2; cl09118 511437001222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437001223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437001224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437001225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001226 putative substrate translocation pore; other site 511437001227 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 511437001228 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 511437001229 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 511437001230 N- and C-terminal domain interface [polypeptide binding]; other site 511437001231 D-xylulose kinase; Region: XylB; TIGR01312 511437001232 active site 511437001233 catalytic site [active] 511437001234 metal binding site [ion binding]; metal-binding site 511437001235 xylulose binding site [chemical binding]; other site 511437001236 putative ATP binding site [chemical binding]; other site 511437001237 homodimer interface [polypeptide binding]; other site 511437001238 TIGR03987 family protein; Region: TIGR03987 511437001239 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437001240 Helix-turn-helix domains; Region: HTH; cl00088 511437001241 drug efflux system protein MdtG; Provisional; Region: PRK09874 511437001242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001243 putative substrate translocation pore; other site 511437001244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001246 active site 511437001247 catalytic tetrad [active] 511437001248 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 511437001249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437001250 putative NAD(P) binding site [chemical binding]; other site 511437001251 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437001252 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437001253 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 511437001254 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 511437001255 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437001256 Walker A/P-loop; other site 511437001257 ATP binding site [chemical binding]; other site 511437001258 Q-loop/lid; other site 511437001259 ABC transporter signature motif; other site 511437001260 Walker B; other site 511437001261 D-loop; other site 511437001262 H-loop/switch region; other site 511437001263 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437001264 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 511437001265 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001266 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001267 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437001268 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 511437001269 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 511437001270 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 511437001271 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437001272 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 511437001273 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 511437001274 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 511437001275 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 511437001276 active site 511437001277 Fe-S cluster binding site [ion binding]; other site 511437001278 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 511437001279 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437001280 lipoyl attachment site [posttranslational modification]; other site 511437001281 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 511437001282 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 511437001283 tetramer interface [polypeptide binding]; other site 511437001284 active site 511437001285 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437001286 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437001287 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437001288 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437001289 lipoyl attachment site [posttranslational modification]; other site 511437001290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001292 active site 511437001293 catalytic tetrad [active] 511437001294 Predicted membrane protein [Function unknown]; Region: COG3428 511437001295 Bacterial PH domain; Region: DUF304; cl01348 511437001296 Bacterial PH domain; Region: DUF304; cl01348 511437001297 Bacterial PH domain; Region: DUF304; cl01348 511437001298 Bacterial PH domain; Region: DUF304; cl01348 511437001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001301 putative substrate translocation pore; other site 511437001302 acetoin reductase; Validated; Region: PRK08643 511437001303 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 511437001304 NAD binding site [chemical binding]; other site 511437001305 homotetramer interface [polypeptide binding]; other site 511437001306 homodimer interface [polypeptide binding]; other site 511437001307 active site 511437001308 substrate binding site [chemical binding]; other site 511437001309 Integral membrane protein DUF95; Region: DUF95; cl00572 511437001310 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001311 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001312 active site 511437001313 catalytic tetrad [active] 511437001314 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511437001315 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511437001316 Walker A/P-loop; other site 511437001317 ATP binding site [chemical binding]; other site 511437001318 Q-loop/lid; other site 511437001319 ABC transporter signature motif; other site 511437001320 Walker B; other site 511437001321 D-loop; other site 511437001322 H-loop/switch region; other site 511437001323 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 511437001324 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437001325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001326 Helix-turn-helix domains; Region: HTH; cl00088 511437001327 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 511437001328 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 511437001329 putative peptidoglycan binding site; other site 511437001330 3D domain; Region: 3D; cl01439 511437001331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511437001332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511437001333 ligand binding site [chemical binding]; other site 511437001334 flexible hinge region; other site 511437001335 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 511437001336 non-specific DNA interactions [nucleotide binding]; other site 511437001337 DNA binding site [nucleotide binding] 511437001338 sequence specific DNA binding site [nucleotide binding]; other site 511437001339 putative cAMP binding site [chemical binding]; other site 511437001340 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 511437001341 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511437001342 putative N- and C-terminal domain interface [polypeptide binding]; other site 511437001343 putative active site [active] 511437001344 putative MgATP binding site [chemical binding]; other site 511437001345 catalytic site [active] 511437001346 metal binding site [ion binding]; metal-binding site 511437001347 putative carbohydrate binding site [chemical binding]; other site 511437001348 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 511437001349 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 511437001350 intersubunit interface [polypeptide binding]; other site 511437001351 active site 511437001352 Zn2+ binding site [ion binding]; other site 511437001353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511437001354 active site 511437001355 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511437001356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437001357 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 511437001358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437001359 active site 511437001360 metal binding site [ion binding]; metal-binding site 511437001361 hexamer interface [polypeptide binding]; other site 511437001362 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 511437001363 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511437001364 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437001365 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 511437001366 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 511437001367 active site 511437001368 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437001369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437001370 ABC transporter; Region: ABC_tran_2; pfam12848 511437001371 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437001372 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 511437001373 catalytic triad [active] 511437001374 catalytic triad [active] 511437001375 oxyanion hole [active] 511437001376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001377 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 511437001378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437001379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001380 NAD(P) binding site [chemical binding]; other site 511437001381 active site 511437001382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001383 Helix-turn-helix domains; Region: HTH; cl00088 511437001384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001385 Helix-turn-helix domains; Region: HTH; cl00088 511437001386 putative transposase OrfB; Reviewed; Region: PHA02517 511437001387 HTH-like domain; Region: HTH_21; pfam13276 511437001388 Integrase core domain; Region: rve; cl01316 511437001389 Integrase core domain; Region: rve_3; cl15866 511437001390 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 511437001391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001392 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001393 active site 511437001394 catalytic tetrad [active] 511437001395 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511437001396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437001397 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437001398 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511437001399 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511437001400 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511437001401 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 511437001402 xanthine permease; Region: pbuX; TIGR03173 511437001403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437001404 Helix-turn-helix domains; Region: HTH; cl00088 511437001405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511437001406 dimerization interface [polypeptide binding]; other site 511437001407 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 511437001408 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437001409 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437001410 Arginine repressor [Transcription]; Region: ArgR; COG1438 511437001411 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511437001412 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511437001413 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437001414 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437001415 Amidinotransferase; Region: Amidinotransf; cl12043 511437001416 ornithine carbamoyltransferase; Validated; Region: PRK02102 511437001417 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511437001418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001419 carbamate kinase; Reviewed; Region: PRK12686 511437001420 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511437001421 putative substrate binding site [chemical binding]; other site 511437001422 nucleotide binding site [chemical binding]; other site 511437001423 nucleotide binding site [chemical binding]; other site 511437001424 homodimer interface [polypeptide binding]; other site 511437001425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511437001426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511437001427 ligand binding site [chemical binding]; other site 511437001428 flexible hinge region; other site 511437001429 Helix-turn-helix domains; Region: HTH; cl00088 511437001430 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 511437001431 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437001432 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437001433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001434 motif II; other site 511437001435 DsrE/DsrF-like family; Region: DrsE; cl00672 511437001436 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511437001437 DNA binding site [nucleotide binding] 511437001438 active site 511437001439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001440 non-specific DNA binding site [nucleotide binding]; other site 511437001441 salt bridge; other site 511437001442 sequence-specific DNA binding site [nucleotide binding]; other site 511437001443 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511437001444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001445 phosphodiesterase; Provisional; Region: PRK12704 511437001446 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 511437001447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437001448 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 511437001449 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 511437001450 active site 511437001451 metal binding site [ion binding]; metal-binding site 511437001452 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511437001453 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001454 putative catalytic residues [active] 511437001455 thiol/disulfide switch; other site 511437001456 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437001457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437001458 active site 511437001459 motif I; other site 511437001460 motif II; other site 511437001461 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437001462 Helix-turn-helix domains; Region: HTH; cl00088 511437001463 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437001464 Integrase core domain; Region: rve; cl01316 511437001465 Integrase core domain; Region: rve_3; cl15866 511437001466 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001467 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 511437001468 active site 511437001469 Protease prsW family; Region: PrsW-protease; cl15823 511437001470 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 511437001471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437001473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001474 Walker A/P-loop; other site 511437001475 ATP binding site [chemical binding]; other site 511437001476 Q-loop/lid; other site 511437001477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001478 ABC transporter signature motif; other site 511437001479 Walker B; other site 511437001480 D-loop; other site 511437001481 H-loop/switch region; other site 511437001482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001483 AAA domain; Region: AAA_21; pfam13304 511437001484 Walker A/P-loop; other site 511437001485 ATP binding site [chemical binding]; other site 511437001486 Q-loop/lid; other site 511437001487 ABC transporter signature motif; other site 511437001488 Walker B; other site 511437001489 D-loop; other site 511437001490 H-loop/switch region; other site 511437001491 Ion transport protein; Region: Ion_trans; pfam00520 511437001492 Ion channel; Region: Ion_trans_2; cl11596 511437001493 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511437001494 Sulfatase; Region: Sulfatase; cl10460 511437001495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001496 catalytic core [active] 511437001497 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437001498 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 511437001499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001500 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437001501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437001502 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437001503 NlpC/P60 family; Region: NLPC_P60; cl11438 511437001504 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 511437001505 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 511437001506 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437001507 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 511437001508 active site 511437001509 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437001510 Integral membrane protein TerC family; Region: TerC; cl10468 511437001511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437001512 catalytic residues [active] 511437001513 Predicted acetyltransferase [General function prediction only]; Region: COG3153 511437001514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001515 Coenzyme A binding pocket [chemical binding]; other site 511437001516 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 511437001517 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 511437001518 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 511437001519 putative peptidoglycan binding site; other site 511437001520 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437001521 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 511437001522 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 511437001523 active site 511437001524 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 511437001525 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 511437001526 GDP-binding site [chemical binding]; other site 511437001527 ACT binding site; other site 511437001528 IMP binding site; other site 511437001529 adenylosuccinate lyase; Provisional; Region: PRK07492 511437001530 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 511437001531 tetramer interface [polypeptide binding]; other site 511437001532 active site 511437001533 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 511437001534 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 511437001535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001536 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 511437001537 Predicted membrane protein [Function unknown]; Region: COG2364 511437001538 glycerol kinase; Provisional; Region: glpK; PRK00047 511437001539 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 511437001540 N- and C-terminal domain interface [polypeptide binding]; other site 511437001541 active site 511437001542 MgATP binding site [chemical binding]; other site 511437001543 catalytic site [active] 511437001544 metal binding site [ion binding]; metal-binding site 511437001545 glycerol binding site [chemical binding]; other site 511437001546 homotetramer interface [polypeptide binding]; other site 511437001547 homodimer interface [polypeptide binding]; other site 511437001548 FBP binding site [chemical binding]; other site 511437001549 protein IIAGlc interface [polypeptide binding]; other site 511437001550 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 511437001551 TRAM domain; Region: TRAM; cl01282 511437001552 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 511437001553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 511437001554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437001555 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437001556 active site 511437001557 catalytic tetrad [active] 511437001558 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511437001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001560 Coenzyme A binding pocket [chemical binding]; other site 511437001561 short chain dehydrogenase; Validated; Region: PRK06182 511437001562 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511437001563 NADP binding site [chemical binding]; other site 511437001564 active site 511437001565 steroid binding site; other site 511437001566 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 511437001567 substrate binding site [chemical binding]; other site 511437001568 multimerization interface [polypeptide binding]; other site 511437001569 ATP binding site [chemical binding]; other site 511437001570 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511437001571 dimer interface [polypeptide binding]; other site 511437001572 substrate binding site [chemical binding]; other site 511437001573 ATP binding site [chemical binding]; other site 511437001574 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511437001575 thiamine phosphate binding site [chemical binding]; other site 511437001576 active site 511437001577 pyrophosphate binding site [ion binding]; other site 511437001578 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001579 active site 511437001580 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 511437001581 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 511437001582 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 511437001583 active site 511437001584 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 511437001585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437001586 non-specific DNA binding site [nucleotide binding]; other site 511437001587 salt bridge; other site 511437001588 sequence-specific DNA binding site [nucleotide binding]; other site 511437001589 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437001590 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511437001591 Walker A/P-loop; other site 511437001592 ATP binding site [chemical binding]; other site 511437001593 Q-loop/lid; other site 511437001594 ABC transporter signature motif; other site 511437001595 Walker B; other site 511437001596 D-loop; other site 511437001597 H-loop/switch region; other site 511437001598 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 511437001599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511437001600 FtsX-like permease family; Region: FtsX; cl15850 511437001601 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511437001602 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437001603 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437001604 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437001605 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437001606 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437001607 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 511437001608 RelB antitoxin; Region: RelB; cl01171 511437001609 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 511437001610 NlpC/P60 family; Region: NLPC_P60; cl11438 511437001611 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511437001612 dimerization domain swap beta strand [polypeptide binding]; other site 511437001613 regulatory protein interface [polypeptide binding]; other site 511437001614 active site 511437001615 regulatory phosphorylation site [posttranslational modification]; other site 511437001616 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437001617 peptidase domain interface [polypeptide binding]; other site 511437001618 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437001619 active site 511437001620 catalytic triad [active] 511437001621 calcium binding site [ion binding]; other site 511437001622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001623 Helix-turn-helix domains; Region: HTH; cl00088 511437001624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437001625 Helix-turn-helix domains; Region: HTH; cl00088 511437001626 putative transposase OrfB; Reviewed; Region: PHA02517 511437001627 HTH-like domain; Region: HTH_21; pfam13276 511437001628 Integrase core domain; Region: rve; cl01316 511437001629 Integrase core domain; Region: rve_3; cl15866 511437001630 Uncharacterized conserved protein [Function unknown]; Region: COG3760 511437001631 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 511437001632 putative deacylase active site [active] 511437001633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511437001634 Helix-turn-helix domains; Region: HTH; cl00088 511437001635 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 511437001636 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 511437001637 active site 511437001638 zinc binding site [ion binding]; other site 511437001639 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 511437001640 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 511437001641 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 511437001642 active site 511437001643 catalytic triad [active] 511437001644 oxyanion hole [active] 511437001645 Sulfatase; Region: Sulfatase; cl10460 511437001646 Sulfatase; Region: Sulfatase; cl10460 511437001647 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 511437001648 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 511437001649 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 511437001650 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511437001651 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511437001652 active site 511437001653 tetramer interface [polypeptide binding]; other site 511437001654 peptidase T; Region: peptidase-T; TIGR01882 511437001655 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511437001656 metal binding site [ion binding]; metal-binding site 511437001657 dimer interface [polypeptide binding]; other site 511437001658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 511437001659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437001660 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511437001661 P loop; other site 511437001662 Nucleotide binding site [chemical binding]; other site 511437001663 DTAP/Switch II; other site 511437001664 Switch I; other site 511437001665 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437001666 Magnesium ion binding site [ion binding]; other site 511437001667 ParB-like partition proteins; Region: parB_part; TIGR00180 511437001668 ParB-like nuclease domain; Region: ParBc; cl02129 511437001669 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 511437001670 GTP-binding protein YchF; Reviewed; Region: PRK09601 511437001671 YchF GTPase; Region: YchF; cd01900 511437001672 G1 box; other site 511437001673 GTP/Mg2+ binding site [chemical binding]; other site 511437001674 Switch I region; other site 511437001675 G2 box; other site 511437001676 Switch II region; other site 511437001677 G3 box; other site 511437001678 G4 box; other site 511437001679 G5 box; other site 511437001680 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 511437001681 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 511437001682 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 511437001683 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 511437001684 active site 511437001685 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 511437001686 nudix motif; other site 511437001687 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 511437001688 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 511437001689 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 511437001690 active site 511437001691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437001693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437001694 active site 511437001695 phosphorylation site [posttranslational modification] 511437001696 intermolecular recognition site; other site 511437001697 dimerization interface [polypeptide binding]; other site 511437001698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437001699 DNA binding site [nucleotide binding] 511437001700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437001701 dimer interface [polypeptide binding]; other site 511437001702 phosphorylation site [posttranslational modification] 511437001703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437001704 ATP binding site [chemical binding]; other site 511437001705 Mg2+ binding site [ion binding]; other site 511437001706 G-X-G motif; other site 511437001707 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511437001708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437001709 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 511437001710 AzlC protein; Region: AzlC; cl00570 511437001711 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 511437001712 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 511437001713 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511437001714 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 511437001715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001716 catalytic core [active] 511437001717 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437001718 inner membrane transporter YjeM; Provisional; Region: PRK15238 511437001719 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437001720 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437001721 active site 511437001722 substrate binding site [chemical binding]; other site 511437001723 trimer interface [polypeptide binding]; other site 511437001724 CoA binding site [chemical binding]; other site 511437001725 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 511437001726 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511437001727 minor groove reading motif; other site 511437001728 helix-hairpin-helix signature motif; other site 511437001729 substrate binding pocket [chemical binding]; other site 511437001730 active site 511437001731 Sugar transport protein; Region: Sugar_transport; pfam06800 511437001732 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 511437001733 DNA-binding site [nucleotide binding]; DNA binding site 511437001734 RNA-binding motif; other site 511437001735 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 511437001736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437001737 Helix-turn-helix domains; Region: HTH; cl00088 511437001738 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 511437001739 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511437001740 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437001741 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 511437001742 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 511437001743 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437001744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001745 putative substrate translocation pore; other site 511437001746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001747 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 511437001748 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437001749 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 511437001750 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 511437001751 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 511437001752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437001753 CAAX protease self-immunity; Region: Abi; cl00558 511437001754 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001755 active site 511437001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437001757 Coenzyme A binding pocket [chemical binding]; other site 511437001758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001760 putative substrate translocation pore; other site 511437001761 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 511437001762 nudix motif; other site 511437001763 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437001764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001765 Fic family protein [Function unknown]; Region: COG3177 511437001766 Fic/DOC family; Region: Fic; cl00960 511437001767 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 511437001768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437001769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001770 homodimer interface [polypeptide binding]; other site 511437001771 catalytic residue [active] 511437001772 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 511437001773 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437001774 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 511437001775 NAD(P) binding site [chemical binding]; other site 511437001776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001777 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437001778 NAD(P) binding site [chemical binding]; other site 511437001779 active site 511437001780 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511437001781 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511437001782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437001783 DNA-binding site [nucleotide binding]; DNA binding site 511437001784 FCD domain; Region: FCD; cl11656 511437001785 mannonate dehydratase; Provisional; Region: PRK03906 511437001786 mannonate dehydratase; Region: uxuA; TIGR00695 511437001787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437001788 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 511437001789 substrate binding site [chemical binding]; other site 511437001790 ATP binding site [chemical binding]; other site 511437001791 Protein of unknown function (DUF975); Region: DUF975; cl10504 511437001792 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437001793 Haemolysin-III related; Region: HlyIII; cl03831 511437001794 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 511437001795 histidinol dehydrogenase; Region: hisD; TIGR00069 511437001796 NAD binding site [chemical binding]; other site 511437001797 dimerization interface [polypeptide binding]; other site 511437001798 product binding site; other site 511437001799 substrate binding site [chemical binding]; other site 511437001800 zinc binding site [ion binding]; other site 511437001801 catalytic residues [active] 511437001802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437001803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437001804 putative substrate translocation pore; other site 511437001805 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 511437001806 amphipathic channel; other site 511437001807 Asn-Pro-Ala signature motifs; other site 511437001808 Protein of unknown function (DUF975); Region: DUF975; cl10504 511437001809 cystathionine gamma-synthase; Reviewed; Region: PRK08247 511437001810 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437001811 homodimer interface [polypeptide binding]; other site 511437001812 substrate-cofactor binding pocket; other site 511437001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437001814 catalytic residue [active] 511437001815 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 511437001816 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 511437001817 dimer interface [polypeptide binding]; other site 511437001818 active site 511437001819 metal binding site [ion binding]; metal-binding site 511437001820 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511437001821 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 511437001822 NAD binding site [chemical binding]; other site 511437001823 substrate binding site [chemical binding]; other site 511437001824 homodimer interface [polypeptide binding]; other site 511437001825 active site 511437001826 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 511437001827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001828 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437001829 DNA binding residues [nucleotide binding] 511437001830 putative dimer interface [polypeptide binding]; other site 511437001831 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437001832 active site 511437001833 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 511437001834 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511437001835 active site 511437001836 HIGH motif; other site 511437001837 dimer interface [polypeptide binding]; other site 511437001838 KMSKS motif; other site 511437001839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 511437001840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437001841 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511437001842 ArsC family; Region: ArsC; pfam03960 511437001843 putative catalytic residues [active] 511437001844 thiol/disulfide switch; other site 511437001845 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 511437001846 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511437001847 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511437001848 Ligand binding site; other site 511437001849 Putative Catalytic site; other site 511437001850 DXD motif; other site 511437001851 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 511437001852 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 511437001853 GtrA-like protein; Region: GtrA; cl00971 511437001854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437001855 active site 511437001856 phosphorylation site [posttranslational modification] 511437001857 intermolecular recognition site; other site 511437001858 dimerization interface [polypeptide binding]; other site 511437001859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437001860 DNA binding site [nucleotide binding] 511437001861 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 511437001862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437001863 dimer interface [polypeptide binding]; other site 511437001864 phosphorylation site [posttranslational modification] 511437001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437001866 ATP binding site [chemical binding]; other site 511437001867 Mg2+ binding site [ion binding]; other site 511437001868 G-X-G motif; other site 511437001869 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 511437001870 Competence protein CoiA-like family; Region: CoiA; cl11541 511437001871 oligoendopeptidase F; Region: pepF; TIGR00181 511437001872 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 511437001873 active site 511437001874 Zn binding site [ion binding]; other site 511437001875 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 511437001876 Thioredoxin; Region: Thioredoxin_5; pfam13743 511437001877 catalytic residues [active] 511437001878 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437001879 synthetase active site [active] 511437001880 NTP binding site [chemical binding]; other site 511437001881 metal binding site [ion binding]; metal-binding site 511437001882 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511437001883 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437001884 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 511437001885 active site 511437001886 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 511437001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437001888 S-adenosylmethionine binding site [chemical binding]; other site 511437001889 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 511437001890 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 511437001891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437001892 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 511437001893 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 511437001894 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 511437001895 cell division protein MraZ; Reviewed; Region: PRK00326 511437001896 MraZ protein; Region: MraZ; pfam02381 511437001897 MraZ protein; Region: MraZ; pfam02381 511437001898 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 511437001899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001900 Septum formation initiator; Region: DivIC; cl11433 511437001901 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511437001902 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437001903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437001904 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 511437001905 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 511437001906 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 511437001907 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511437001908 Mg++ binding site [ion binding]; other site 511437001909 putative catalytic motif [active] 511437001910 putative substrate binding site [chemical binding]; other site 511437001911 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 511437001912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437001913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437001914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437001915 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511437001916 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511437001917 active site 511437001918 homodimer interface [polypeptide binding]; other site 511437001919 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 511437001920 Cell division protein FtsQ; Region: FtsQ; pfam03799 511437001921 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 511437001922 Cell division protein FtsA; Region: FtsA; cl11496 511437001923 Cell division protein FtsA; Region: FtsA; cl11496 511437001924 cell division protein FtsZ; Validated; Region: PRK09330 511437001925 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511437001926 nucleotide binding site [chemical binding]; other site 511437001927 SulA interaction site; other site 511437001928 Protein of unknown function (DUF552); Region: DUF552; cl00775 511437001929 YGGT family; Region: YGGT; cl00508 511437001930 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 511437001931 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437001932 RNA binding surface [nucleotide binding]; other site 511437001933 DivIVA protein; Region: DivIVA; pfam05103 511437001934 DivIVA domain; Region: DivI1A_domain; TIGR03544 511437001935 Plant ATP synthase F0; Region: YMF19; cl07975 511437001936 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 511437001937 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437001938 active site 511437001939 HIGH motif; other site 511437001940 nucleotide binding site [chemical binding]; other site 511437001941 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511437001942 active site 511437001943 KMSKS motif; other site 511437001944 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 511437001945 tRNA binding surface [nucleotide binding]; other site 511437001946 anticodon binding site; other site 511437001947 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511437001948 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 511437001949 DNA-binding site [nucleotide binding]; DNA binding site 511437001950 RNA-binding motif; other site 511437001951 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511437001952 dimer interface [polypeptide binding]; other site 511437001953 ADP-ribose binding site [chemical binding]; other site 511437001954 active site 511437001955 nudix motif; other site 511437001956 metal binding site [ion binding]; metal-binding site 511437001957 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511437001958 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511437001959 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 511437001960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437001961 catalytic residue [active] 511437001962 Putative amino acid metabolism; Region: DUF1831; pfam08866 511437001963 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511437001964 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511437001965 homodimer interface [polypeptide binding]; other site 511437001966 substrate-cofactor binding pocket; other site 511437001967 catalytic residue [active] 511437001968 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511437001969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511437001970 homodimer interface [polypeptide binding]; other site 511437001971 substrate-cofactor binding pocket; other site 511437001972 catalytic residue [active] 511437001973 histidinol-phosphatase; Reviewed; Region: PRK08123 511437001974 PHP-associated; Region: PHP_C; pfam13263 511437001975 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 511437001976 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 511437001977 dimer interface [polypeptide binding]; other site 511437001978 motif 1; other site 511437001979 active site 511437001980 motif 2; other site 511437001981 motif 3; other site 511437001982 ATP phosphoribosyltransferase; Region: HisG; cl15266 511437001983 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 511437001984 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 511437001985 putative active site pocket [active] 511437001986 4-fold oligomerization interface [polypeptide binding]; other site 511437001987 metal binding residues [ion binding]; metal-binding site 511437001988 3-fold/trimer interface [polypeptide binding]; other site 511437001989 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 511437001990 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 511437001991 putative active site [active] 511437001992 oxyanion strand; other site 511437001993 catalytic triad [active] 511437001994 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 511437001995 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511437001996 catalytic residues [active] 511437001997 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 511437001998 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511437001999 substrate binding site [chemical binding]; other site 511437002000 glutamase interaction surface [polypeptide binding]; other site 511437002001 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 511437002002 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 511437002003 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 511437002004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437002005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437002006 homodimer interface [polypeptide binding]; other site 511437002007 catalytic residue [active] 511437002008 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 511437002009 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511437002010 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437002011 catalytic core [active] 511437002012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511437002013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511437002014 binding surface 511437002015 TPR motif; other site 511437002016 TPR repeat; Region: TPR_11; pfam13414 511437002017 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 511437002018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437002019 Family description; Region: UvrD_C_2; cl15862 511437002020 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511437002021 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511437002022 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002023 active site 511437002024 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 511437002025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437002026 active site 511437002027 catalytic tetrad [active] 511437002028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437002029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437002030 DNA binding site [nucleotide binding] 511437002031 domain linker motif; other site 511437002032 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437002033 dimerization interface [polypeptide binding]; other site 511437002034 ligand binding site [chemical binding]; other site 511437002035 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511437002036 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511437002037 substrate binding site [chemical binding]; other site 511437002038 dimer interface [polypeptide binding]; other site 511437002039 ATP binding site [chemical binding]; other site 511437002040 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 511437002041 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511437002042 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511437002043 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511437002044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437002045 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511437002046 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 511437002047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437002048 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437002049 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511437002050 active site 511437002051 catalytic residues [active] 511437002052 metal binding site [ion binding]; metal-binding site 511437002053 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 511437002054 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511437002055 TPP-binding site [chemical binding]; other site 511437002056 heterodimer interface [polypeptide binding]; other site 511437002057 tetramer interface [polypeptide binding]; other site 511437002058 phosphorylation loop region [posttranslational modification] 511437002059 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511437002060 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511437002061 alpha subunit interface [polypeptide binding]; other site 511437002062 TPP binding site [chemical binding]; other site 511437002063 heterodimer interface [polypeptide binding]; other site 511437002064 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511437002065 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511437002066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511437002067 E3 interaction surface; other site 511437002068 lipoyl attachment site [posttranslational modification]; other site 511437002069 e3 binding domain; Region: E3_binding; pfam02817 511437002070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 511437002071 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 511437002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437002073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437002074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437002075 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 511437002076 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 511437002077 active site 511437002078 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 511437002079 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 511437002080 G1 box; other site 511437002081 putative GEF interaction site [polypeptide binding]; other site 511437002082 GTP/Mg2+ binding site [chemical binding]; other site 511437002083 Switch I region; other site 511437002084 G2 box; other site 511437002085 G3 box; other site 511437002086 Switch II region; other site 511437002087 G4 box; other site 511437002088 G5 box; other site 511437002089 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 511437002090 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 511437002091 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511437002092 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 511437002093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002094 S-adenosylmethionine binding site [chemical binding]; other site 511437002095 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511437002096 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511437002097 active site 511437002098 (T/H)XGH motif; other site 511437002099 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 511437002100 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 511437002101 protein binding site [polypeptide binding]; other site 511437002102 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 511437002103 SLBB domain; Region: SLBB; pfam10531 511437002104 comEA protein; Region: comE; TIGR01259 511437002105 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 511437002106 catalytic motif [active] 511437002107 Zn binding site [ion binding]; other site 511437002108 Competence protein; Region: Competence; cl00471 511437002109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437002110 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511437002111 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511437002112 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 511437002113 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511437002114 16S/18S rRNA binding site [nucleotide binding]; other site 511437002115 S13e-L30e interaction site [polypeptide binding]; other site 511437002116 25S rRNA binding site [nucleotide binding]; other site 511437002117 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511437002118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437002119 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511437002120 elongation factor Tu; Reviewed; Region: PRK00049 511437002121 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511437002122 G1 box; other site 511437002123 GEF interaction site [polypeptide binding]; other site 511437002124 GTP/Mg2+ binding site [chemical binding]; other site 511437002125 Switch I region; other site 511437002126 G2 box; other site 511437002127 G3 box; other site 511437002128 Switch II region; other site 511437002129 G4 box; other site 511437002130 G5 box; other site 511437002131 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511437002132 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511437002133 Antibiotic Binding Site [chemical binding]; other site 511437002134 trigger factor; Provisional; Region: tig; PRK01490 511437002135 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 511437002136 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511437002137 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511437002138 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 511437002139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002140 Walker A motif; other site 511437002141 ATP binding site [chemical binding]; other site 511437002142 Walker B motif; other site 511437002143 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437002144 Predicted GTPase [General function prediction only]; Region: COG0218 511437002145 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 511437002146 G1 box; other site 511437002147 GTP/Mg2+ binding site [chemical binding]; other site 511437002148 Switch I region; other site 511437002149 G2 box; other site 511437002150 G3 box; other site 511437002151 Switch II region; other site 511437002152 G4 box; other site 511437002153 G5 box; other site 511437002154 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 511437002155 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 511437002156 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511437002157 ANP binding site [chemical binding]; other site 511437002158 Substrate Binding Site II [chemical binding]; other site 511437002159 Substrate Binding Site I [chemical binding]; other site 511437002160 argininosuccinate lyase; Provisional; Region: PRK00855 511437002161 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511437002162 active sites [active] 511437002163 tetramer interface [polypeptide binding]; other site 511437002164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002165 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002166 substrate binding pocket [chemical binding]; other site 511437002167 membrane-bound complex binding site; other site 511437002168 hinge residues; other site 511437002169 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002171 dimer interface [polypeptide binding]; other site 511437002172 conserved gate region; other site 511437002173 putative PBP binding loops; other site 511437002174 ABC-ATPase subunit interface; other site 511437002175 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437002176 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 511437002177 Walker A/P-loop; other site 511437002178 ATP binding site [chemical binding]; other site 511437002179 Q-loop/lid; other site 511437002180 ABC transporter signature motif; other site 511437002181 Walker B; other site 511437002182 D-loop; other site 511437002183 H-loop/switch region; other site 511437002184 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511437002185 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511437002186 GIY-YIG motif/motif A; other site 511437002187 active site 511437002188 catalytic site [active] 511437002189 putative DNA binding site [nucleotide binding]; other site 511437002190 metal binding site [ion binding]; metal-binding site 511437002191 UvrB/uvrC motif; Region: UVR; pfam02151 511437002192 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511437002193 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 511437002194 DNA binding site [nucleotide binding] 511437002195 GTPase CgtA; Reviewed; Region: obgE; PRK12297 511437002196 GTP1/OBG; Region: GTP1_OBG; pfam01018 511437002197 Obg GTPase; Region: Obg; cd01898 511437002198 G1 box; other site 511437002199 GTP/Mg2+ binding site [chemical binding]; other site 511437002200 Switch I region; other site 511437002201 G2 box; other site 511437002202 G3 box; other site 511437002203 Switch II region; other site 511437002204 G4 box; other site 511437002205 G5 box; other site 511437002206 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 511437002207 OpgC protein; Region: OpgC_C; cl00792 511437002208 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437002209 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 511437002210 catalytic triad [active] 511437002211 catalytic triad [active] 511437002212 oxyanion hole [active] 511437002213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511437002214 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 511437002215 DHH family; Region: DHH; pfam01368 511437002216 DHHA1 domain; Region: DHHA1; pfam02272 511437002217 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 511437002218 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 511437002219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002220 active site 511437002221 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511437002222 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 511437002223 RNA binding site [nucleotide binding]; other site 511437002224 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 511437002225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002226 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002227 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437002228 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 511437002229 Walker A/P-loop; other site 511437002230 ATP binding site [chemical binding]; other site 511437002231 Q-loop/lid; other site 511437002232 ABC transporter signature motif; other site 511437002233 Walker B; other site 511437002234 D-loop; other site 511437002235 H-loop/switch region; other site 511437002236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002238 substrate binding pocket [chemical binding]; other site 511437002239 membrane-bound complex binding site; other site 511437002240 hinge residues; other site 511437002241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002243 substrate binding pocket [chemical binding]; other site 511437002244 membrane-bound complex binding site; other site 511437002245 hinge residues; other site 511437002246 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002248 dimer interface [polypeptide binding]; other site 511437002249 conserved gate region; other site 511437002250 putative PBP binding loops; other site 511437002251 ABC-ATPase subunit interface; other site 511437002252 transaminase; Reviewed; Region: PRK08068 511437002253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437002254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437002255 homodimer interface [polypeptide binding]; other site 511437002256 catalytic residue [active] 511437002257 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 511437002258 DNA polymerase IV; Reviewed; Region: PRK03103 511437002259 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 511437002260 active site 511437002261 DNA binding site [nucleotide binding] 511437002262 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 511437002263 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437002264 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437002265 active site 511437002266 substrate binding site [chemical binding]; other site 511437002267 trimer interface [polypeptide binding]; other site 511437002268 CoA binding site [chemical binding]; other site 511437002269 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 511437002270 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 511437002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437002272 Coenzyme A binding pocket [chemical binding]; other site 511437002273 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 511437002274 putative deacylase active site [active] 511437002275 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 511437002276 hypothetical protein; Provisional; Region: PRK06132 511437002277 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 511437002278 Tic20-like protein; Region: Tic20; pfam09685 511437002279 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 511437002280 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 511437002281 Helix-turn-helix domains; Region: HTH; cl00088 511437002282 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511437002283 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 511437002284 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437002285 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437002286 amidase catalytic site [active] 511437002287 Zn binding residues [ion binding]; other site 511437002288 substrate binding site [chemical binding]; other site 511437002289 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 511437002290 Aspartase; Region: Aspartase; cd01357 511437002291 active sites [active] 511437002292 tetramer interface [polypeptide binding]; other site 511437002293 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511437002294 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437002295 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437002296 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437002297 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437002298 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437002299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437002300 Helix-turn-helix domains; Region: HTH; cl00088 511437002301 Helix-turn-helix domains; Region: HTH; cl00088 511437002302 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511437002303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437002304 Coenzyme A binding pocket [chemical binding]; other site 511437002305 B3/4 domain; Region: B3_4; cl11458 511437002306 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511437002307 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 511437002308 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 511437002309 trimer interface [polypeptide binding]; other site 511437002310 active site 511437002311 substrate binding site [chemical binding]; other site 511437002312 CoA binding site [chemical binding]; other site 511437002313 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437002314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437002315 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437002316 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437002317 catalytic Zn binding site [ion binding]; other site 511437002318 NAD binding site [chemical binding]; other site 511437002319 structural Zn binding site [ion binding]; other site 511437002320 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 511437002321 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 511437002322 NAD binding site [chemical binding]; other site 511437002323 catalytic residues [active] 511437002324 substrate binding site [chemical binding]; other site 511437002325 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437002326 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511437002327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437002328 putative substrate translocation pore; other site 511437002329 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 511437002330 putative active site [active] 511437002331 putative FMN binding site [chemical binding]; other site 511437002332 putative substrate binding site [chemical binding]; other site 511437002333 putative catalytic residue [active] 511437002334 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 511437002335 FMN binding site [chemical binding]; other site 511437002336 dimer interface [polypeptide binding]; other site 511437002337 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 511437002338 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437002339 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 511437002340 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 511437002341 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 511437002342 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 511437002343 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 511437002344 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 511437002345 nucleotide binding site/active site [active] 511437002346 HIT family signature motif; other site 511437002347 catalytic residue [active] 511437002348 VanZ like family; Region: VanZ; cl01971 511437002349 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 511437002350 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511437002351 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437002352 peptidase domain interface [polypeptide binding]; other site 511437002353 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437002354 active site 511437002355 catalytic triad [active] 511437002356 calcium binding site [ion binding]; other site 511437002357 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511437002358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437002359 putative substrate translocation pore; other site 511437002360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002361 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437002362 active site 511437002363 motif I; other site 511437002364 motif II; other site 511437002365 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437002366 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 511437002367 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 511437002368 putative active site [active] 511437002369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437002370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437002371 active site 511437002372 phosphorylation site [posttranslational modification] 511437002373 intermolecular recognition site; other site 511437002374 dimerization interface [polypeptide binding]; other site 511437002375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437002376 DNA binding site [nucleotide binding] 511437002377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 511437002378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511437002379 dimerization interface [polypeptide binding]; other site 511437002380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437002381 dimer interface [polypeptide binding]; other site 511437002382 phosphorylation site [posttranslational modification] 511437002383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437002384 ATP binding site [chemical binding]; other site 511437002385 Mg2+ binding site [ion binding]; other site 511437002386 G-X-G motif; other site 511437002387 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437002388 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437002389 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437002390 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437002391 Protein of unknown function (DUF419); Region: DUF419; cl15265 511437002392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437002393 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 511437002394 catalytic triad [active] 511437002395 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 511437002396 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437002397 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 511437002398 thymidine kinase; Provisional; Region: PRK04296 511437002399 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511437002400 RF-1 domain; Region: RF-1; cl02875 511437002401 RF-1 domain; Region: RF-1; cl02875 511437002402 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 511437002403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002404 S-adenosylmethionine binding site [chemical binding]; other site 511437002405 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 511437002406 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 511437002407 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511437002408 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511437002409 dimer interface [polypeptide binding]; other site 511437002410 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511437002411 active site 511437002412 folate binding site [chemical binding]; other site 511437002413 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437002414 active site 511437002415 ATP synthase A chain; Region: ATP-synt_A; cl00413 511437002416 ATP synthase subunit C; Region: ATP-synt_C; cl00466 511437002417 Plant ATP synthase F0; Region: YMF19; cl07975 511437002418 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 511437002419 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 511437002420 Plant ATP synthase F0; Region: YMF19; cl07975 511437002421 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 511437002422 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 511437002423 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 511437002424 beta subunit interaction interface [polypeptide binding]; other site 511437002425 Walker A motif; other site 511437002426 ATP binding site [chemical binding]; other site 511437002427 Walker B motif; other site 511437002428 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511437002429 ATP synthase; Region: ATP-synt; cl00365 511437002430 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 511437002431 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 511437002432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 511437002433 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 511437002434 alpha subunit interaction interface [polypeptide binding]; other site 511437002435 Walker A motif; other site 511437002436 ATP binding site [chemical binding]; other site 511437002437 Walker B motif; other site 511437002438 inhibitor binding site; inhibition site 511437002439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511437002440 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 511437002441 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 511437002442 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 511437002443 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 511437002444 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511437002445 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511437002446 hinge; other site 511437002447 active site 511437002448 rod shape-determining protein MreB; Provisional; Region: PRK13930 511437002449 Cell division protein FtsA; Region: FtsA; cl11496 511437002450 Haemolytic domain; Region: Haemolytic; cl00506 511437002451 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 511437002452 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511437002453 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437002454 lipoyl attachment site [posttranslational modification]; other site 511437002455 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 511437002456 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 511437002457 Walker A/P-loop; other site 511437002458 ATP binding site [chemical binding]; other site 511437002459 Q-loop/lid; other site 511437002460 ABC transporter signature motif; other site 511437002461 Walker B; other site 511437002462 D-loop; other site 511437002463 H-loop/switch region; other site 511437002464 NIL domain; Region: NIL; cl09633 511437002465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002466 dimer interface [polypeptide binding]; other site 511437002467 conserved gate region; other site 511437002468 ABC-ATPase subunit interface; other site 511437002469 NMT1-like family; Region: NMT1_2; cl15260 511437002470 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 511437002471 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437002472 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 511437002473 Walker A/P-loop; other site 511437002474 ATP binding site [chemical binding]; other site 511437002475 Q-loop/lid; other site 511437002476 ABC transporter signature motif; other site 511437002477 Walker B; other site 511437002478 D-loop; other site 511437002479 H-loop/switch region; other site 511437002480 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 511437002481 Predicted transcriptional regulators [Transcription]; Region: COG1725 511437002482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437002483 DNA-binding site [nucleotide binding]; DNA binding site 511437002484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511437002485 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511437002486 Walker A/P-loop; other site 511437002487 ATP binding site [chemical binding]; other site 511437002488 Q-loop/lid; other site 511437002489 ABC transporter signature motif; other site 511437002490 Walker B; other site 511437002491 D-loop; other site 511437002492 H-loop/switch region; other site 511437002493 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 511437002494 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511437002495 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437002496 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437002497 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511437002498 active site 511437002499 catalytic site [active] 511437002500 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 511437002501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437002502 non-specific DNA binding site [nucleotide binding]; other site 511437002503 salt bridge; other site 511437002504 sequence-specific DNA binding site [nucleotide binding]; other site 511437002505 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437002506 Ligand Binding Site [chemical binding]; other site 511437002507 recombination factor protein RarA; Reviewed; Region: PRK13342 511437002508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002509 Walker A motif; other site 511437002510 ATP binding site [chemical binding]; other site 511437002511 Walker B motif; other site 511437002512 arginine finger; other site 511437002513 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511437002514 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511437002515 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511437002516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437002517 RNA binding surface [nucleotide binding]; other site 511437002518 GAF domain; Region: GAF; cl15785 511437002519 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 511437002520 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511437002521 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 511437002522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511437002523 catalytic residue [active] 511437002524 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 511437002525 THUMP domain; Region: THUMP; cl12076 511437002526 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511437002527 Ligand Binding Site [chemical binding]; other site 511437002528 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 511437002529 dimer interface [polypeptide binding]; other site 511437002530 catalytic triad [active] 511437002531 peroxidatic and resolving cysteines [active] 511437002532 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511437002533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437002534 active site 511437002535 HIGH motif; other site 511437002536 nucleotide binding site [chemical binding]; other site 511437002537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511437002538 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511437002539 active site 511437002540 KMSKS motif; other site 511437002541 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511437002542 tRNA binding surface [nucleotide binding]; other site 511437002543 anticodon binding site; other site 511437002544 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511437002545 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511437002546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437002547 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437002548 rod shape-determining protein MreB; Provisional; Region: PRK13927 511437002549 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 511437002550 ATP binding site [chemical binding]; other site 511437002551 Cell division protein FtsA; Region: FtsA; cl11496 511437002552 rod shape-determining protein MreC; Provisional; Region: PRK13922 511437002553 rod shape-determining protein MreC; Region: MreC; pfam04085 511437002554 rod shape-determining protein MreD; Region: MreD; cl01087 511437002555 septum formation inhibitor; Reviewed; Region: minC; PRK00513 511437002556 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 511437002557 septum site-determining protein MinD; Region: minD_bact; TIGR01968 511437002558 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 511437002559 Switch I; other site 511437002560 Switch II; other site 511437002561 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437002563 dimer interface [polypeptide binding]; other site 511437002564 conserved gate region; other site 511437002565 putative PBP binding loops; other site 511437002566 ABC-ATPase subunit interface; other site 511437002567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511437002568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437002569 Walker A/P-loop; other site 511437002570 ATP binding site [chemical binding]; other site 511437002571 Q-loop/lid; other site 511437002572 ABC transporter signature motif; other site 511437002573 Walker B; other site 511437002574 D-loop; other site 511437002575 H-loop/switch region; other site 511437002576 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437002577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437002578 substrate binding pocket [chemical binding]; other site 511437002579 membrane-bound complex binding site; other site 511437002580 hinge residues; other site 511437002581 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511437002582 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511437002583 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511437002584 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511437002585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437002586 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511437002587 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 511437002588 Competence-damaged protein; Region: CinA; cl00666 511437002589 recombinase A; Provisional; Region: recA; PRK09354 511437002590 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511437002591 hexamer interface [polypeptide binding]; other site 511437002592 Walker A motif; other site 511437002593 ATP binding site [chemical binding]; other site 511437002594 Walker B motif; other site 511437002595 phosphodiesterase; Provisional; Region: PRK12704 511437002596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437002597 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 511437002598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437002599 putative active site [active] 511437002600 metal binding site [ion binding]; metal-binding site 511437002601 homodimer binding site [polypeptide binding]; other site 511437002602 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 511437002603 MutS domain I; Region: MutS_I; pfam01624 511437002604 MutS domain II; Region: MutS_II; pfam05188 511437002605 MutS family domain IV; Region: MutS_IV; pfam05190 511437002606 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 511437002607 Walker A/P-loop; other site 511437002608 ATP binding site [chemical binding]; other site 511437002609 Q-loop/lid; other site 511437002610 ABC transporter signature motif; other site 511437002611 Walker B; other site 511437002612 D-loop; other site 511437002613 H-loop/switch region; other site 511437002614 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 511437002615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437002616 ATP binding site [chemical binding]; other site 511437002617 Mg2+ binding site [ion binding]; other site 511437002618 G-X-G motif; other site 511437002619 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 511437002620 ATP binding site [chemical binding]; other site 511437002621 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 511437002622 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511437002623 RuvA N terminal domain; Region: RuvA_N; pfam01330 511437002624 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511437002625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437002626 Walker A motif; other site 511437002627 ATP binding site [chemical binding]; other site 511437002628 Walker B motif; other site 511437002629 arginine finger; other site 511437002630 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511437002631 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 511437002632 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511437002633 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 511437002634 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511437002635 Preprotein translocase subunit; Region: YajC; cl00806 511437002636 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511437002637 active site 511437002638 DNA polymerase IV; Validated; Region: PRK02406 511437002639 DNA binding site [nucleotide binding] 511437002640 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511437002641 DHH family; Region: DHH; pfam01368 511437002642 DHHA1 domain; Region: DHHA1; pfam02272 511437002643 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511437002644 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511437002645 ATP binding site [chemical binding]; other site 511437002646 Mg++ binding site [ion binding]; other site 511437002647 motif III; other site 511437002648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437002649 nucleotide binding region [chemical binding]; other site 511437002650 ATP-binding site [chemical binding]; other site 511437002651 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511437002652 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 511437002653 motif 1; other site 511437002654 active site 511437002655 motif 2; other site 511437002656 motif 3; other site 511437002657 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 511437002658 DHHA1 domain; Region: DHHA1; pfam02272 511437002659 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 511437002660 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 511437002661 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 511437002662 Cell division protein ZapA; Region: ZapA; cl01146 511437002663 Colicin V production protein; Region: Colicin_V; cl00567 511437002664 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 511437002665 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 511437002666 Walker A/P-loop; other site 511437002667 ATP binding site [chemical binding]; other site 511437002668 Q-loop/lid; other site 511437002669 ABC transporter signature motif; other site 511437002670 Walker B; other site 511437002671 D-loop; other site 511437002672 H-loop/switch region; other site 511437002673 Domain of unknown function DUF148; Region: DUF148; pfam02520 511437002674 Smr domain; Region: Smr; cl02619 511437002675 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437002676 catalytic residues [active] 511437002677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002678 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002679 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 511437002680 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 511437002681 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511437002682 active site 511437002683 dimerization interface [polypeptide binding]; other site 511437002684 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511437002685 active site 511437002686 metal binding site [ion binding]; metal-binding site 511437002687 homotetramer interface [polypeptide binding]; other site 511437002688 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 511437002689 FOG: CBS domain [General function prediction only]; Region: COG0517 511437002690 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511437002691 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 511437002692 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511437002693 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511437002694 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511437002695 active site 511437002696 catabolite control protein A; Region: ccpA; TIGR01481 511437002697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437002698 DNA binding site [nucleotide binding] 511437002699 domain linker motif; other site 511437002700 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 511437002701 dimerization interface [polypeptide binding]; other site 511437002702 effector binding site; other site 511437002703 Transcriptional regulator; Region: Transcrip_reg; cl00361 511437002704 Type II/IV secretion system protein; Region: T2SE; pfam00437 511437002705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437002706 Walker A motif; other site 511437002707 ATP binding site [chemical binding]; other site 511437002708 Walker B motif; other site 511437002709 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511437002710 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511437002711 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 511437002712 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 511437002713 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 511437002714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437002715 Acetokinase family; Region: Acetate_kinase; cl01029 511437002716 propionate/acetate kinase; Provisional; Region: PRK12379 511437002717 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437002718 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 511437002719 putative active site [active] 511437002720 putative metal binding site [ion binding]; other site 511437002721 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 511437002722 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511437002723 active site 511437002724 metal binding site [ion binding]; metal-binding site 511437002725 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511437002726 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 511437002727 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 511437002728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002729 active site 511437002730 motif I; other site 511437002731 motif II; other site 511437002732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002733 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 511437002734 PspC domain; Region: PspC; cl00864 511437002735 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 511437002736 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 511437002737 dimer interface [polypeptide binding]; other site 511437002738 active site 511437002739 LexA repressor; Validated; Region: PRK00215 511437002740 Helix-turn-helix domains; Region: HTH; cl00088 511437002741 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511437002742 Catalytic site [active] 511437002743 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 511437002744 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 511437002745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002746 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437002748 putative acyl-acceptor binding pocket; other site 511437002749 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 511437002750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002751 S-adenosylmethionine binding site [chemical binding]; other site 511437002752 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 511437002753 GIY-YIG motif/motif A; other site 511437002754 putative active site [active] 511437002755 putative metal binding site [ion binding]; other site 511437002756 D-lactate dehydrogenase; Validated; Region: PRK08605 511437002757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437002758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437002759 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437002760 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511437002761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002762 motif II; other site 511437002763 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511437002764 rRNA interaction site [nucleotide binding]; other site 511437002765 S8 interaction site; other site 511437002766 putative laminin-1 binding site; other site 511437002767 elongation factor Ts; Provisional; Region: tsf; PRK09377 511437002768 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 511437002769 Elongation factor TS; Region: EF_TS; pfam00889 511437002770 Elongation factor TS; Region: EF_TS; pfam00889 511437002771 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511437002772 putative nucleotide binding site [chemical binding]; other site 511437002773 uridine monophosphate binding site [chemical binding]; other site 511437002774 homohexameric interface [polypeptide binding]; other site 511437002775 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 511437002776 ribosome recycling factor; Reviewed; Region: frr; PRK00083 511437002777 hinge region; other site 511437002778 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 511437002779 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 511437002780 catalytic residue [active] 511437002781 putative FPP diphosphate binding site; other site 511437002782 putative FPP binding hydrophobic cleft; other site 511437002783 dimer interface [polypeptide binding]; other site 511437002784 putative IPP diphosphate binding site; other site 511437002785 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 511437002786 RIP metalloprotease RseP; Region: TIGR00054 511437002787 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511437002788 active site 511437002789 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511437002790 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511437002791 protein binding site [polypeptide binding]; other site 511437002792 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511437002793 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511437002794 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 511437002795 dimer interface [polypeptide binding]; other site 511437002796 motif 1; other site 511437002797 active site 511437002798 motif 2; other site 511437002799 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511437002800 putative deacylase active site [active] 511437002801 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 511437002802 active site 511437002803 motif 3; other site 511437002804 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511437002805 anticodon binding site; other site 511437002806 DNA polymerase III PolC; Validated; Region: polC; PRK00448 511437002807 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 511437002808 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 511437002809 generic binding surface I; other site 511437002810 generic binding surface II; other site 511437002811 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511437002812 active site 511437002813 substrate binding site [chemical binding]; other site 511437002814 catalytic site [active] 511437002815 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 511437002816 ribosome maturation protein RimP; Reviewed; Region: PRK00092 511437002817 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 511437002818 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 511437002819 Sm1 motif; other site 511437002820 predicted subunit interaction site [polypeptide binding]; other site 511437002821 RNA binding pocket [nucleotide binding]; other site 511437002822 Sm2 motif; other site 511437002823 transcription termination factor NusA; Region: NusA; TIGR01953 511437002824 NusA N-terminal domain; Region: NusA_N; pfam08529 511437002825 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511437002826 RNA binding site [nucleotide binding]; other site 511437002827 homodimer interface [polypeptide binding]; other site 511437002828 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 511437002829 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511437002830 G-X-X-G motif; other site 511437002831 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 511437002832 putative RNA binding cleft [nucleotide binding]; other site 511437002833 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 511437002834 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511437002835 translation initiation factor IF-2; Region: IF-2; TIGR00487 511437002836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511437002837 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511437002838 G1 box; other site 511437002839 putative GEF interaction site [polypeptide binding]; other site 511437002840 GTP/Mg2+ binding site [chemical binding]; other site 511437002841 Switch I region; other site 511437002842 G2 box; other site 511437002843 G3 box; other site 511437002844 Switch II region; other site 511437002845 G4 box; other site 511437002846 G5 box; other site 511437002847 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511437002848 Translation-initiation factor 2; Region: IF-2; pfam11987 511437002849 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511437002850 Ribosome-binding factor A; Region: RBFA; cl00542 511437002851 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 511437002852 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 511437002853 RNA binding site [nucleotide binding]; other site 511437002854 active site 511437002855 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511437002856 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511437002857 active site 511437002858 Riboflavin kinase; Region: Flavokinase; cl03312 511437002859 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 511437002860 Helix-turn-helix domains; Region: HTH; cl00088 511437002861 HrcA protein C terminal domain; Region: HrcA; pfam01628 511437002862 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511437002863 dimer interface [polypeptide binding]; other site 511437002864 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511437002865 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511437002866 chaperone protein DnaJ; Provisional; Region: PRK14276 511437002867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511437002868 HSP70 interaction site [polypeptide binding]; other site 511437002869 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511437002870 substrate binding site [polypeptide binding]; other site 511437002871 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511437002872 Zn binding sites [ion binding]; other site 511437002873 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511437002874 dimer interface [polypeptide binding]; other site 511437002875 GTP-binding protein LepA; Provisional; Region: PRK05433 511437002876 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511437002877 G1 box; other site 511437002878 putative GEF interaction site [polypeptide binding]; other site 511437002879 GTP/Mg2+ binding site [chemical binding]; other site 511437002880 Switch I region; other site 511437002881 G2 box; other site 511437002882 G3 box; other site 511437002883 Switch II region; other site 511437002884 G4 box; other site 511437002885 G5 box; other site 511437002886 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511437002887 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511437002888 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511437002889 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 511437002890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437002891 S-adenosylmethionine binding site [chemical binding]; other site 511437002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 511437002893 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 511437002894 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511437002895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437002896 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437002897 synthetase active site [active] 511437002898 NTP binding site [chemical binding]; other site 511437002899 metal binding site [ion binding]; metal-binding site 511437002900 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511437002901 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511437002902 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511437002903 putative active site [active] 511437002904 dimerization interface [polypeptide binding]; other site 511437002905 putative tRNAtyr binding site [nucleotide binding]; other site 511437002906 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437002907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437002908 motif II; other site 511437002909 Bacterial SH3 domain; Region: SH3_3; cl02551 511437002910 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511437002911 active site 511437002912 metal binding site [ion binding]; metal-binding site 511437002913 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511437002914 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 511437002915 dimer interface [polypeptide binding]; other site 511437002916 motif 1; other site 511437002917 active site 511437002918 motif 2; other site 511437002919 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511437002920 anticodon binding site; other site 511437002921 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511437002922 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511437002923 dimer interface [polypeptide binding]; other site 511437002924 anticodon binding site; other site 511437002925 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 511437002926 homodimer interface [polypeptide binding]; other site 511437002927 motif 1; other site 511437002928 active site 511437002929 motif 2; other site 511437002930 GAD domain; Region: GAD; pfam02938 511437002931 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 511437002932 active site 511437002933 motif 3; other site 511437002934 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437002935 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437002936 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437002937 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 511437002938 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 511437002939 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437002940 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 511437002941 endonuclease IV; Provisional; Region: PRK01060 511437002942 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511437002943 AP (apurinic/apyrimidinic) site pocket; other site 511437002944 DNA interaction; other site 511437002945 Metal-binding active site; metal-binding site 511437002946 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 511437002947 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 511437002948 GatB domain; Region: GatB_Yqey; cl11497 511437002949 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511437002950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437002951 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 511437002952 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 511437002953 GTPase Era; Reviewed; Region: era; PRK00089 511437002954 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511437002955 G1 box; other site 511437002956 GTP/Mg2+ binding site [chemical binding]; other site 511437002957 Switch I region; other site 511437002958 G2 box; other site 511437002959 Switch II region; other site 511437002960 G3 box; other site 511437002961 G4 box; other site 511437002962 G5 box; other site 511437002963 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 511437002964 DNA repair protein RecO; Region: reco; TIGR00613 511437002965 Recombination protein O N terminal; Region: RecO_N; cl15812 511437002966 Recombination protein O C terminal; Region: RecO_C; pfam02565 511437002967 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 511437002968 dimer interface [polypeptide binding]; other site 511437002969 motif 1; other site 511437002970 active site 511437002971 motif 2; other site 511437002972 motif 3; other site 511437002973 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 511437002974 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511437002975 DNA primase; Validated; Region: dnaG; PRK05667 511437002976 CHC2 zinc finger; Region: zf-CHC2; cl15369 511437002977 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511437002978 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511437002979 active site 511437002980 metal binding site [ion binding]; metal-binding site 511437002981 interdomain interaction site; other site 511437002982 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 511437002983 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 511437002984 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511437002985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437002986 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511437002987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511437002988 DNA binding residues [nucleotide binding] 511437002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437002990 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 511437002991 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 511437002992 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 511437002993 peptidase T; Region: peptidase-T; TIGR01882 511437002994 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511437002995 metal binding site [ion binding]; metal-binding site 511437002996 dimer interface [polypeptide binding]; other site 511437002997 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 511437002998 Clp amino terminal domain; Region: Clp_N; pfam02861 511437002999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003000 Walker A motif; other site 511437003001 ATP binding site [chemical binding]; other site 511437003002 Walker B motif; other site 511437003003 arginine finger; other site 511437003004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003005 Walker A motif; other site 511437003006 ATP binding site [chemical binding]; other site 511437003007 Walker B motif; other site 511437003008 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437003009 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 511437003010 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437003011 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 511437003012 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 511437003013 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 511437003014 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511437003015 generic binding surface I; other site 511437003016 generic binding surface II; other site 511437003017 pyruvate kinase; Provisional; Region: PRK06354 511437003018 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 511437003019 domain interfaces; other site 511437003020 active site 511437003021 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 511437003022 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 511437003023 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511437003024 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 511437003025 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 511437003026 Int/Topo IB signature motif; other site 511437003027 active site 511437003028 ScpA/B protein; Region: ScpA_ScpB; cl00598 511437003029 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 511437003030 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 511437003031 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437003032 RNA binding surface [nucleotide binding]; other site 511437003033 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 511437003034 active site 511437003035 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511437003036 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511437003037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 511437003038 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511437003039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003040 ATP binding site [chemical binding]; other site 511437003041 putative Mg++ binding site [ion binding]; other site 511437003042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437003043 nucleotide binding region [chemical binding]; other site 511437003044 ATP-binding site [chemical binding]; other site 511437003045 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 511437003046 putative peptidoglycan binding site; other site 511437003047 cytidylate kinase; Provisional; Region: cmk; PRK00023 511437003048 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511437003049 CMP-binding site; other site 511437003050 The sites determining sugar specificity; other site 511437003051 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 511437003052 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511437003053 RNA binding site [nucleotide binding]; other site 511437003054 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 511437003055 RNA binding site [nucleotide binding]; other site 511437003056 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 511437003057 RNA binding site [nucleotide binding]; other site 511437003058 GTP-binding protein Der; Reviewed; Region: PRK00093 511437003059 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 511437003060 G1 box; other site 511437003061 GTP/Mg2+ binding site [chemical binding]; other site 511437003062 Switch I region; other site 511437003063 G2 box; other site 511437003064 Switch II region; other site 511437003065 G3 box; other site 511437003066 G4 box; other site 511437003067 G5 box; other site 511437003068 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 511437003069 G1 box; other site 511437003070 GTP/Mg2+ binding site [chemical binding]; other site 511437003071 Switch I region; other site 511437003072 G2 box; other site 511437003073 G3 box; other site 511437003074 Switch II region; other site 511437003075 G4 box; other site 511437003076 G5 box; other site 511437003077 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511437003078 IHF dimer interface [polypeptide binding]; other site 511437003079 IHF - DNA interface [nucleotide binding]; other site 511437003080 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 511437003081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511437003082 TPR motif; other site 511437003083 binding surface 511437003084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511437003085 binding surface 511437003086 TPR motif; other site 511437003087 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437003088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003089 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437003090 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 511437003091 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 511437003092 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511437003093 active site 511437003094 NTP binding site [chemical binding]; other site 511437003095 metal binding triad [ion binding]; metal-binding site 511437003096 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511437003097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437003098 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437003099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003100 Walker A/P-loop; other site 511437003101 ATP binding site [chemical binding]; other site 511437003102 Q-loop/lid; other site 511437003103 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437003104 ABC transporter signature motif; other site 511437003105 Walker B; other site 511437003106 D-loop; other site 511437003107 ABC transporter; Region: ABC_tran_2; pfam12848 511437003108 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437003109 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 511437003110 dimerization interface [polypeptide binding]; other site 511437003111 active site 511437003112 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 511437003113 folate binding site [chemical binding]; other site 511437003114 NADP+ binding site [chemical binding]; other site 511437003115 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437003116 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 511437003117 active site 511437003118 catalytic triad [active] 511437003119 oxyanion hole [active] 511437003120 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 511437003121 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 511437003122 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 511437003123 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 511437003124 GTP/Mg2+ binding site [chemical binding]; other site 511437003125 G4 box; other site 511437003126 G5 box; other site 511437003127 G1 box; other site 511437003128 Switch I region; other site 511437003129 G2 box; other site 511437003130 G3 box; other site 511437003131 Switch II region; other site 511437003132 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511437003133 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437003134 active site 511437003135 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 511437003136 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 511437003137 DNA topoisomerase I; Validated; Region: PRK05582 511437003138 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 511437003139 active site 511437003140 interdomain interaction site; other site 511437003141 putative metal-binding site [ion binding]; other site 511437003142 nucleotide binding site [chemical binding]; other site 511437003143 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511437003144 domain I; other site 511437003145 DNA binding groove [nucleotide binding] 511437003146 phosphate binding site [ion binding]; other site 511437003147 domain II; other site 511437003148 domain III; other site 511437003149 nucleotide binding site [chemical binding]; other site 511437003150 catalytic site [active] 511437003151 domain IV; other site 511437003152 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511437003153 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511437003154 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 511437003155 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437003156 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 511437003157 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437003158 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 511437003159 active site 1 [active] 511437003160 dimer interface [polypeptide binding]; other site 511437003161 hexamer interface [polypeptide binding]; other site 511437003162 active site 2 [active] 511437003163 glycerol kinase; Provisional; Region: glpK; PRK00047 511437003164 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 511437003165 N- and C-terminal domain interface [polypeptide binding]; other site 511437003166 active site 511437003167 MgATP binding site [chemical binding]; other site 511437003168 catalytic site [active] 511437003169 metal binding site [ion binding]; metal-binding site 511437003170 glycerol binding site [chemical binding]; other site 511437003171 homotetramer interface [polypeptide binding]; other site 511437003172 homodimer interface [polypeptide binding]; other site 511437003173 FBP binding site [chemical binding]; other site 511437003174 protein IIAGlc interface [polypeptide binding]; other site 511437003175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003176 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437003177 active site 511437003178 motif I; other site 511437003179 motif II; other site 511437003180 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437003181 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 511437003182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003183 S-adenosylmethionine binding site [chemical binding]; other site 511437003184 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 511437003185 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 511437003186 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 511437003187 homotetramer interface [polypeptide binding]; other site 511437003188 FMN binding site [chemical binding]; other site 511437003189 homodimer contacts [polypeptide binding]; other site 511437003190 putative active site [active] 511437003191 putative substrate binding site [chemical binding]; other site 511437003192 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 511437003193 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437003194 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 511437003195 mevalonate kinase; Region: mevalon_kin; TIGR00549 511437003196 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437003197 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437003198 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 511437003199 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511437003200 active site 511437003201 substrate binding site [chemical binding]; other site 511437003202 catalytic site [active] 511437003203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 511437003206 aspartate aminotransferase; Provisional; Region: PRK05764 511437003207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437003208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437003209 homodimer interface [polypeptide binding]; other site 511437003210 catalytic residue [active] 511437003211 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511437003212 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 511437003213 putative dimer interface [polypeptide binding]; other site 511437003214 putative anticodon binding site; other site 511437003215 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511437003216 homodimer interface [polypeptide binding]; other site 511437003217 motif 1; other site 511437003218 motif 2; other site 511437003219 active site 511437003220 motif 3; other site 511437003221 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 511437003222 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 511437003223 Transglycosylase; Region: Transgly; cl07896 511437003224 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511437003225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437003226 Recombination protein U; Region: RecU; cl01314 511437003227 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 511437003228 cell division protein GpsB; Provisional; Region: PRK14127 511437003229 DivIVA domain; Region: DivI1A_domain; TIGR03544 511437003230 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 511437003231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437003232 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 511437003233 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437003234 active site 511437003235 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 511437003236 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 511437003237 Potassium binding sites [ion binding]; other site 511437003238 Cesium cation binding sites [ion binding]; other site 511437003239 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 511437003240 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 511437003241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437003242 RNA binding surface [nucleotide binding]; other site 511437003243 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 511437003244 active site 511437003245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437003246 active site 511437003247 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511437003248 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 511437003249 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511437003250 catalytic site [active] 511437003251 subunit interface [polypeptide binding]; other site 511437003252 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 511437003253 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437003254 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 511437003255 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511437003256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437003257 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 511437003258 Domain of unknown function (DUF814); Region: DUF814; pfam05670 511437003259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437003260 Helix-turn-helix domains; Region: HTH; cl00088 511437003261 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437003262 hypothetical protein; Provisional; Region: PRK09609 511437003263 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 511437003264 active site 511437003265 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511437003266 catalytic center binding site [active] 511437003267 ATP binding site [chemical binding]; other site 511437003268 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 511437003269 GTP cyclohydrolase I; Provisional; Region: PLN03044 511437003270 active site 511437003271 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511437003272 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003273 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003274 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511437003275 dihydropteroate synthase; Region: DHPS; TIGR01496 511437003276 substrate binding pocket [chemical binding]; other site 511437003277 dimer interface [polypeptide binding]; other site 511437003278 inhibitor binding site; inhibition site 511437003279 Transposase domain (DUF772); Region: DUF772; cl15789 511437003280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437003281 Transposase domain (DUF772); Region: DUF772; cl15789 511437003282 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 511437003283 nudix motif; other site 511437003284 putative acetyltransferase; Provisional; Region: PRK03624 511437003285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437003286 Coenzyme A binding pocket [chemical binding]; other site 511437003287 LicD family; Region: LicD; cl01378 511437003288 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 511437003289 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511437003290 DNA binding site [nucleotide binding] 511437003291 Int/Topo IB signature motif; other site 511437003292 active site 511437003293 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 511437003294 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511437003295 minor groove reading motif; other site 511437003296 helix-hairpin-helix signature motif; other site 511437003297 substrate binding pocket [chemical binding]; other site 511437003298 active site 511437003299 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 511437003300 DNA binding and oxoG recognition site [nucleotide binding] 511437003301 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 511437003302 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 511437003303 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 511437003304 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 511437003305 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511437003306 DHHA2 domain; Region: DHHA2; pfam02833 511437003307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437003308 Helix-turn-helix domains; Region: HTH; cl00088 511437003309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511437003310 dimerization interface [polypeptide binding]; other site 511437003311 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 511437003312 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 511437003313 CAP-like domain; other site 511437003314 active site 511437003315 primary dimer interface [polypeptide binding]; other site 511437003316 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437003317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511437003318 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511437003319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437003320 ATP binding site [chemical binding]; other site 511437003321 Mg2+ binding site [ion binding]; other site 511437003322 G-X-G motif; other site 511437003323 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511437003324 anchoring element; other site 511437003325 dimer interface [polypeptide binding]; other site 511437003326 ATP binding site [chemical binding]; other site 511437003327 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511437003328 active site 511437003329 putative metal-binding site [ion binding]; other site 511437003330 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511437003331 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511437003332 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 511437003333 active site 511437003334 catalytic residues [active] 511437003335 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 511437003336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003337 Walker A motif; other site 511437003338 ATP binding site [chemical binding]; other site 511437003339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437003341 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 511437003342 active site 511437003343 HslU subunit interaction site [polypeptide binding]; other site 511437003344 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 511437003345 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 511437003346 Int/Topo IB signature motif; other site 511437003347 active site 511437003348 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 511437003349 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 511437003350 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 511437003351 RimM N-terminal domain; Region: RimM; pfam01782 511437003352 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 511437003353 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 511437003354 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 511437003355 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 511437003356 signal recognition particle protein; Provisional; Region: PRK10867 511437003357 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 511437003358 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511437003359 P loop; other site 511437003360 GTP binding site [chemical binding]; other site 511437003361 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511437003362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437003363 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 511437003364 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511437003365 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 511437003366 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511437003367 P loop; other site 511437003368 GTP binding site [chemical binding]; other site 511437003369 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511437003370 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 511437003371 Walker A/P-loop; other site 511437003372 ATP binding site [chemical binding]; other site 511437003373 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 511437003374 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 511437003375 ABC transporter signature motif; other site 511437003376 Walker B; other site 511437003377 D-loop; other site 511437003378 H-loop/switch region; other site 511437003379 ribonuclease III; Reviewed; Region: rnc; PRK00102 511437003380 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511437003381 dimerization interface [polypeptide binding]; other site 511437003382 active site 511437003383 metal binding site [ion binding]; metal-binding site 511437003384 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511437003385 dsRNA binding site [nucleotide binding]; other site 511437003386 Phosphopantetheine attachment site; Region: PP-binding; cl09936 511437003387 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 511437003388 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511437003389 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511437003390 generic binding surface II; other site 511437003391 ssDNA binding site; other site 511437003392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003393 ATP binding site [chemical binding]; other site 511437003394 putative Mg++ binding site [ion binding]; other site 511437003395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437003396 nucleotide binding region [chemical binding]; other site 511437003397 ATP-binding site [chemical binding]; other site 511437003398 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 511437003399 DAK2 domain; Region: Dak2; cl03685 511437003400 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437003401 Asp23 family; Region: Asp23; cl00574 511437003402 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 511437003403 Thiamine pyrophosphokinase; Region: TPK; cd07995 511437003404 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 511437003405 active site 511437003406 dimerization interface [polypeptide binding]; other site 511437003407 thiamine binding site [chemical binding]; other site 511437003408 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 511437003409 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511437003410 substrate binding site [chemical binding]; other site 511437003411 hexamer interface [polypeptide binding]; other site 511437003412 metal binding site [ion binding]; metal-binding site 511437003413 GTPase RsgA; Reviewed; Region: PRK00098 511437003414 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 511437003415 RNA binding site [nucleotide binding]; other site 511437003416 homodimer interface [polypeptide binding]; other site 511437003417 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 511437003418 GTPase/Zn-binding domain interface [polypeptide binding]; other site 511437003419 GTP/Mg2+ binding site [chemical binding]; other site 511437003420 G4 box; other site 511437003421 G5 box; other site 511437003422 G1 box; other site 511437003423 Switch I region; other site 511437003424 G2 box; other site 511437003425 G3 box; other site 511437003426 Switch II region; other site 511437003427 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 511437003428 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 511437003429 active site 511437003430 ATP binding site [chemical binding]; other site 511437003431 substrate binding site [chemical binding]; other site 511437003432 activation loop (A-loop); other site 511437003433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 511437003434 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511437003435 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 511437003436 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511437003437 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 511437003438 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 511437003439 active site 511437003440 16S rRNA methyltransferase B; Provisional; Region: PRK14902 511437003441 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 511437003442 putative RNA binding site [nucleotide binding]; other site 511437003443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 511437003444 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 511437003445 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511437003446 putative active site [active] 511437003447 substrate binding site [chemical binding]; other site 511437003448 putative cosubstrate binding site; other site 511437003449 catalytic site [active] 511437003450 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511437003451 substrate binding site [chemical binding]; other site 511437003452 primosome assembly protein PriA; Validated; Region: PRK05580 511437003453 primosome assembly protein PriA; Validated; Region: PRK05580 511437003454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437003455 ATP binding site [chemical binding]; other site 511437003456 putative Mg++ binding site [ion binding]; other site 511437003457 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003458 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 511437003459 Flavoprotein; Region: Flavoprotein; cl08021 511437003460 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 511437003461 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 511437003462 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511437003463 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511437003464 catalytic site [active] 511437003465 G-X2-G-X-G-K; other site 511437003466 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 511437003467 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 511437003468 Walker A/P-loop; other site 511437003469 ATP binding site [chemical binding]; other site 511437003470 Q-loop/lid; other site 511437003471 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 511437003472 Q-loop/lid; other site 511437003473 ABC transporter signature motif; other site 511437003474 Walker B; other site 511437003475 D-loop; other site 511437003476 H-loop/switch region; other site 511437003477 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511437003478 arginine repressor; Provisional; Region: PRK04280 511437003479 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511437003480 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 511437003481 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 511437003482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 511437003483 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511437003484 substrate binding pocket [chemical binding]; other site 511437003485 chain length determination region; other site 511437003486 substrate-Mg2+ binding site; other site 511437003487 catalytic residues [active] 511437003488 aspartate-rich region 1; other site 511437003489 active site lid residues [active] 511437003490 aspartate-rich region 2; other site 511437003491 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 511437003492 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 511437003493 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 511437003494 generic binding surface II; other site 511437003495 generic binding surface I; other site 511437003496 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 511437003497 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511437003498 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511437003499 homodimer interface [polypeptide binding]; other site 511437003500 NADP binding site [chemical binding]; other site 511437003501 substrate binding site [chemical binding]; other site 511437003502 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 511437003503 putative RNA binding site [nucleotide binding]; other site 511437003504 Asp23 family; Region: Asp23; cl00574 511437003505 elongation factor P; Validated; Region: PRK00529 511437003506 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511437003507 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511437003508 RNA binding site [nucleotide binding]; other site 511437003509 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511437003510 RNA binding site [nucleotide binding]; other site 511437003511 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 511437003512 Protein of unknown function (DUF464); Region: DUF464; cl01080 511437003513 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 511437003514 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 511437003515 dUTPase; Region: dUTPase_2; pfam08761 511437003516 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 511437003517 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437003518 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437003519 peptide binding site [polypeptide binding]; other site 511437003520 glutamine synthetase, type I; Region: GlnA; TIGR00653 511437003521 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511437003522 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511437003523 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437003524 DNA binding residues [nucleotide binding] 511437003525 putative dimer interface [polypeptide binding]; other site 511437003526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003527 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511437003528 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 511437003529 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 511437003530 active site 511437003531 catalytic site [active] 511437003532 metal binding site [ion binding]; metal-binding site 511437003533 dimer interface [polypeptide binding]; other site 511437003534 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 511437003535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511437003536 active site residue [active] 511437003537 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 511437003538 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511437003539 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 511437003540 Rhomboid family; Region: Rhomboid; cl11446 511437003541 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 511437003542 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 511437003543 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511437003544 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437003545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511437003546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437003547 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437003548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 511437003549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437003550 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437003551 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511437003552 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511437003553 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511437003554 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511437003555 Sugar specificity; other site 511437003556 Pyrimidine base specificity; other site 511437003557 ATP-binding site [chemical binding]; other site 511437003558 YceG-like family; Region: YceG; pfam02618 511437003559 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511437003560 dimerization interface [polypeptide binding]; other site 511437003561 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511437003562 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511437003563 putative tRNA-binding site [nucleotide binding]; other site 511437003564 B3/4 domain; Region: B3_4; cl11458 511437003565 tRNA synthetase B5 domain; Region: B5; cl08394 511437003566 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511437003567 dimer interface [polypeptide binding]; other site 511437003568 motif 1; other site 511437003569 motif 3; other site 511437003570 motif 2; other site 511437003571 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 511437003572 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511437003573 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511437003574 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511437003575 dimer interface [polypeptide binding]; other site 511437003576 motif 1; other site 511437003577 active site 511437003578 motif 2; other site 511437003579 motif 3; other site 511437003580 Helix-turn-helix domains; Region: HTH; cl00088 511437003581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437003582 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511437003583 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 511437003584 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 511437003585 Acylphosphatase; Region: Acylphosphatase; cl00551 511437003586 OxaA-like protein precursor; Provisional; Region: PRK02463 511437003587 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 511437003588 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437003589 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 511437003590 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511437003591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437003592 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 511437003593 Helix-turn-helix domains; Region: HTH; cl00088 511437003594 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003595 Integrase core domain; Region: rve; cl01316 511437003596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003597 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 511437003598 Walker A motif; other site 511437003599 ATP binding site [chemical binding]; other site 511437003600 Walker B motif; other site 511437003601 arginine finger; other site 511437003602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003603 Walker A motif; other site 511437003604 ATP binding site [chemical binding]; other site 511437003605 Walker B motif; other site 511437003606 arginine finger; other site 511437003607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437003608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003609 Integrase core domain; Region: rve; cl01316 511437003610 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437003611 Transposase domain (DUF772); Region: DUF772; cl15789 511437003612 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437003613 Transposase domain (DUF772); Region: DUF772; cl15789 511437003614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 511437003615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437003616 dimer interface [polypeptide binding]; other site 511437003617 phosphorylation site [posttranslational modification] 511437003618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437003619 ATP binding site [chemical binding]; other site 511437003620 Mg2+ binding site [ion binding]; other site 511437003621 G-X-G motif; other site 511437003622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437003623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437003624 active site 511437003625 phosphorylation site [posttranslational modification] 511437003626 intermolecular recognition site; other site 511437003627 dimerization interface [polypeptide binding]; other site 511437003628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437003629 DNA binding site [nucleotide binding] 511437003630 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 511437003631 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 511437003632 NAD binding site [chemical binding]; other site 511437003633 substrate binding site [chemical binding]; other site 511437003634 catalytic Zn binding site [ion binding]; other site 511437003635 tetramer interface [polypeptide binding]; other site 511437003636 structural Zn binding site [ion binding]; other site 511437003637 Helix-turn-helix domains; Region: HTH; cl00088 511437003638 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437003639 Integrase core domain; Region: rve; cl01316 511437003640 Integrase core domain; Region: rve_3; cl15866 511437003641 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 511437003642 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 511437003643 hypothetical protein; Provisional; Region: PRK13670 511437003644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511437003645 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 511437003646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437003647 S-adenosylmethionine binding site [chemical binding]; other site 511437003648 Oligomerisation domain; Region: Oligomerisation; cl00519 511437003649 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 511437003650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437003651 Zn2+ binding site [ion binding]; other site 511437003652 Mg2+ binding site [ion binding]; other site 511437003653 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511437003654 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511437003655 active site 511437003656 (T/H)XGH motif; other site 511437003657 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 511437003658 GTPase YqeH; Provisional; Region: PRK13796 511437003659 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 511437003660 GTP/Mg2+ binding site [chemical binding]; other site 511437003661 G4 box; other site 511437003662 G5 box; other site 511437003663 G1 box; other site 511437003664 Switch I region; other site 511437003665 G2 box; other site 511437003666 G3 box; other site 511437003667 Switch II region; other site 511437003668 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 511437003669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003670 active site 511437003671 motif I; other site 511437003672 motif II; other site 511437003673 ribosomal protein L20; Region: rpl20; CHL00068 511437003674 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511437003675 23S rRNA binding site [nucleotide binding]; other site 511437003676 L21 binding site [polypeptide binding]; other site 511437003677 L13 binding site [polypeptide binding]; other site 511437003678 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 511437003679 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 511437003680 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511437003681 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511437003682 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 511437003683 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511437003684 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 511437003685 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511437003686 active site 511437003687 dimer interface [polypeptide binding]; other site 511437003688 motif 1; other site 511437003689 motif 2; other site 511437003690 motif 3; other site 511437003691 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511437003692 anticodon binding site; other site 511437003693 primosomal protein DnaI; Reviewed; Region: PRK08939 511437003694 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 511437003695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437003696 Walker A motif; other site 511437003697 ATP binding site [chemical binding]; other site 511437003698 Walker B motif; other site 511437003699 arginine finger; other site 511437003700 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 511437003701 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 511437003702 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 511437003703 ATP cone domain; Region: ATP-cone; pfam03477 511437003704 dephospho-CoA kinase; Region: TIGR00152 511437003705 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511437003706 CoA-binding site [chemical binding]; other site 511437003707 ATP-binding [chemical binding]; other site 511437003708 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 511437003709 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 511437003710 DNA binding site [nucleotide binding] 511437003711 catalytic residue [active] 511437003712 H2TH interface [polypeptide binding]; other site 511437003713 putative catalytic residues [active] 511437003714 turnover-facilitating residue; other site 511437003715 intercalation triad [nucleotide binding]; other site 511437003716 8OG recognition residue [nucleotide binding]; other site 511437003717 putative reading head residues; other site 511437003718 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511437003719 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511437003720 DNA polymerase I; Provisional; Region: PRK05755 511437003721 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511437003722 active site 511437003723 metal binding site 1 [ion binding]; metal-binding site 511437003724 putative 5' ssDNA interaction site; other site 511437003725 metal binding site 3; metal-binding site 511437003726 metal binding site 2 [ion binding]; metal-binding site 511437003727 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511437003728 putative DNA binding site [nucleotide binding]; other site 511437003729 putative metal binding site [ion binding]; other site 511437003730 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 511437003731 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511437003732 active site 511437003733 DNA binding site [nucleotide binding] 511437003734 catalytic site [active] 511437003735 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 511437003736 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511437003737 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437003738 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003739 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003741 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 511437003742 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511437003743 putative tRNA-binding site [nucleotide binding]; other site 511437003744 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511437003745 catalytic residues [active] 511437003746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 511437003747 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 511437003748 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437003749 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511437003750 Walker A/P-loop; other site 511437003751 ATP binding site [chemical binding]; other site 511437003752 Q-loop/lid; other site 511437003753 ABC transporter signature motif; other site 511437003754 Walker B; other site 511437003755 D-loop; other site 511437003756 H-loop/switch region; other site 511437003757 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 511437003758 HIT family signature motif; other site 511437003759 catalytic residue [active] 511437003760 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 511437003761 SurA N-terminal domain; Region: SurA_N_3; cl07813 511437003762 PPIC-type PPIASE domain; Region: Rotamase; cl08278 511437003763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437003764 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437003765 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 511437003766 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 511437003767 generic binding surface II; other site 511437003768 generic binding surface I; other site 511437003769 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 511437003770 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437003771 Zn2+ binding site [ion binding]; other site 511437003772 Mg2+ binding site [ion binding]; other site 511437003773 Uncharacterized conserved protein [Function unknown]; Region: COG4717 511437003774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437003775 Walker A/P-loop; other site 511437003776 ATP binding site [chemical binding]; other site 511437003777 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511437003778 Uncharacterized conserved protein [Function unknown]; Region: COG4717 511437003779 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 511437003780 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 511437003781 active site 511437003782 metal binding site [ion binding]; metal-binding site 511437003783 DNA binding site [nucleotide binding] 511437003784 Protein of unknown function (DUF964); Region: DUF964; cl01483 511437003785 Transglycosylase; Region: Transgly; cl07896 511437003786 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511437003787 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437003788 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 511437003789 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 511437003790 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511437003791 active site 511437003792 HIGH motif; other site 511437003793 KMSK motif region; other site 511437003794 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 511437003795 tRNA binding surface [nucleotide binding]; other site 511437003796 anticodon binding site; other site 511437003797 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 511437003798 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 511437003799 aspartate racemase; Region: asp_race; TIGR00035 511437003800 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 511437003801 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437003802 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511437003803 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437003804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437003805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437003806 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 511437003807 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 511437003808 active site 511437003809 dimer interface [polypeptide binding]; other site 511437003810 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 511437003811 Ligand Binding Site [chemical binding]; other site 511437003812 Molecular Tunnel; other site 511437003813 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437003814 Ligand Binding Site [chemical binding]; other site 511437003815 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437003816 peptidase domain interface [polypeptide binding]; other site 511437003817 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437003818 active site 511437003819 catalytic triad [active] 511437003820 calcium binding site [ion binding]; other site 511437003821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437003822 Helix-turn-helix domains; Region: HTH; cl00088 511437003823 Helix-turn-helix domains; Region: HTH; cl00088 511437003824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 511437003825 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511437003826 NlpC/P60 family; Region: NLPC_P60; cl11438 511437003827 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 511437003828 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 511437003829 active site 511437003830 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437003831 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437003832 peptide binding site [polypeptide binding]; other site 511437003833 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 511437003834 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 511437003835 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 511437003836 homodimer interface [polypeptide binding]; other site 511437003837 homotetramer interface [polypeptide binding]; other site 511437003838 active site pocket [active] 511437003839 cleavage site 511437003840 CAAX protease self-immunity; Region: Abi; cl00558 511437003841 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437003842 peptidase domain interface [polypeptide binding]; other site 511437003843 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437003844 active site 511437003845 catalytic triad [active] 511437003846 calcium binding site [ion binding]; other site 511437003847 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 511437003848 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 511437003849 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 511437003850 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437003851 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437003852 beta-phosphoglucomutase; Region: bPGM; TIGR01990 511437003853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003854 motif II; other site 511437003855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437003856 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437003857 active site 511437003858 motif I; other site 511437003859 motif II; other site 511437003860 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437003861 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511437003862 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511437003863 Substrate-binding site [chemical binding]; other site 511437003864 Substrate specificity [chemical binding]; other site 511437003865 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 511437003866 Protein of unknown function; Region: DUF3658; pfam12395 511437003867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437003868 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437003869 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437003870 Ligand Binding Site [chemical binding]; other site 511437003871 dipeptidase PepV; Reviewed; Region: PRK07318 511437003872 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511437003873 active site 511437003874 metal binding site [ion binding]; metal-binding site 511437003875 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511437003876 putative substrate binding site [chemical binding]; other site 511437003877 putative ATP binding site [chemical binding]; other site 511437003878 MatE; Region: MatE; cl10513 511437003879 stage V sporulation protein B; Region: spore_V_B; TIGR02900 511437003880 OpgC protein; Region: OpgC_C; cl00792 511437003881 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437003882 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437003883 DNA translocase FtsK; Provisional; Region: PRK10263 511437003884 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511437003885 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511437003886 HIGH motif; other site 511437003887 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511437003888 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511437003889 active site 511437003890 KMSKS motif; other site 511437003891 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511437003892 tRNA binding surface [nucleotide binding]; other site 511437003893 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437003894 active site 511437003895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437003896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437003897 putative substrate translocation pore; other site 511437003898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437003899 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511437003900 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511437003901 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511437003902 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511437003903 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 511437003904 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511437003905 Isochorismatase family; Region: Isochorismatase; pfam00857 511437003906 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511437003907 catalytic triad [active] 511437003908 conserved cis-peptide bond; other site 511437003909 Asp23 family; Region: Asp23; cl00574 511437003910 Asp23 family; Region: Asp23; cl00574 511437003911 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511437003912 putative active site [active] 511437003913 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437003914 Helix-turn-helix domains; Region: HTH; cl00088 511437003915 LicD family; Region: LicD; cl01378 511437003916 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 511437003917 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 511437003918 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 511437003919 Walker A/P-loop; other site 511437003920 ATP binding site [chemical binding]; other site 511437003921 Q-loop/lid; other site 511437003922 ABC transporter signature motif; other site 511437003923 Walker B; other site 511437003924 D-loop; other site 511437003925 H-loop/switch region; other site 511437003926 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437003927 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437003928 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511437003929 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511437003930 glutaminase active site [active] 511437003931 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511437003932 dimer interface [polypeptide binding]; other site 511437003933 active site 511437003934 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511437003935 dimer interface [polypeptide binding]; other site 511437003936 active site 511437003937 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 511437003938 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511437003939 active site 511437003940 substrate binding site [chemical binding]; other site 511437003941 metal binding site [ion binding]; metal-binding site 511437003942 YbbR-like protein; Region: YbbR; pfam07949 511437003943 YbbR-like protein; Region: YbbR; pfam07949 511437003944 Uncharacterized conserved protein [Function unknown]; Region: COG1624 511437003945 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511437003946 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 511437003947 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 511437003948 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 511437003949 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 511437003950 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511437003951 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 511437003952 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 511437003953 FAD binding domain; Region: FAD_binding_4; pfam01565 511437003954 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511437003955 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 511437003956 active site 511437003957 substrate binding site [chemical binding]; other site 511437003958 catalytic site [active] 511437003959 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511437003960 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437003961 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 511437003962 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 511437003963 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 511437003964 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 511437003965 ligand binding site [chemical binding]; other site 511437003966 active site 511437003967 UGI interface [polypeptide binding]; other site 511437003968 catalytic site [active] 511437003969 Scramblase; Region: Scramblase; cl02043 511437003970 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511437003971 SmpB-tmRNA interface; other site 511437003972 ribonuclease R; Region: RNase_R; TIGR02063 511437003973 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511437003974 RNB domain; Region: RNB; pfam00773 511437003975 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 511437003976 RNA binding site [nucleotide binding]; other site 511437003977 Esterase/lipase [General function prediction only]; Region: COG1647 511437003978 Preprotein translocase SecG subunit; Region: SecG; cl09123 511437003979 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 511437003980 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 511437003981 Cl- selectivity filter; other site 511437003982 Cl- binding residues [ion binding]; other site 511437003983 pore gating glutamate residue; other site 511437003984 dimer interface [polypeptide binding]; other site 511437003985 H+/Cl- coupling transport residue; other site 511437003986 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 511437003987 large tegument protein UL36; Provisional; Region: PHA03247 511437003988 enolase; Provisional; Region: eno; PRK00077 511437003989 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511437003990 dimer interface [polypeptide binding]; other site 511437003991 metal binding site [ion binding]; metal-binding site 511437003992 substrate binding pocket [chemical binding]; other site 511437003993 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511437003994 substrate binding site [chemical binding]; other site 511437003995 dimer interface [polypeptide binding]; other site 511437003996 catalytic triad [active] 511437003997 Phosphoglycerate kinase; Region: PGK; pfam00162 511437003998 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511437003999 substrate binding site [chemical binding]; other site 511437004000 hinge regions; other site 511437004001 ADP binding site [chemical binding]; other site 511437004002 catalytic site [active] 511437004003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004004 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 511437004005 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511437004006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511437004007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437004008 Coenzyme A binding pocket [chemical binding]; other site 511437004009 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 511437004010 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437004011 Zn binding site [ion binding]; other site 511437004012 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437004013 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 511437004014 Zn binding site [ion binding]; other site 511437004015 Clp protease; Region: CLP_protease; pfam00574 511437004016 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511437004017 oligomer interface [polypeptide binding]; other site 511437004018 active site residues [active] 511437004019 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 511437004020 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 511437004021 putative NAD(P) binding site [chemical binding]; other site 511437004022 putative substrate binding site [chemical binding]; other site 511437004023 catalytic Zn binding site [ion binding]; other site 511437004024 structural Zn binding site [ion binding]; other site 511437004025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 511437004026 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 511437004027 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 511437004028 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 511437004029 phosphate binding site [ion binding]; other site 511437004030 putative substrate binding pocket [chemical binding]; other site 511437004031 dimer interface [polypeptide binding]; other site 511437004032 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 511437004033 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 511437004034 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511437004035 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 511437004036 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 511437004037 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 511437004038 excinuclease ABC subunit B; Provisional; Region: PRK05298 511437004039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004040 ATP binding site [chemical binding]; other site 511437004041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004042 nucleotide binding region [chemical binding]; other site 511437004043 ATP-binding site [chemical binding]; other site 511437004044 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511437004045 UvrB/uvrC motif; Region: UVR; pfam02151 511437004046 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 511437004047 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511437004048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437004050 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511437004051 active site 511437004052 tetramer interface; other site 511437004053 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 511437004054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004055 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 511437004056 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 511437004057 DRTGG domain; Region: DRTGG; cl12147 511437004058 HPr kinase/phosphorylase; Provisional; Region: PRK05428 511437004059 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 511437004060 Hpr binding site; other site 511437004061 active site 511437004062 homohexamer subunit interaction site [polypeptide binding]; other site 511437004063 Membrane protein of unknown function; Region: DUF360; cl00850 511437004064 PspC domain; Region: PspC; cl00864 511437004065 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511437004066 PhoU domain; Region: PhoU; pfam01895 511437004067 PhoU domain; Region: PhoU; pfam01895 511437004068 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 511437004069 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 511437004070 Walker A/P-loop; other site 511437004071 ATP binding site [chemical binding]; other site 511437004072 Q-loop/lid; other site 511437004073 ABC transporter signature motif; other site 511437004074 Walker B; other site 511437004075 D-loop; other site 511437004076 H-loop/switch region; other site 511437004077 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 511437004078 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 511437004079 Walker A/P-loop; other site 511437004080 ATP binding site [chemical binding]; other site 511437004081 Q-loop/lid; other site 511437004082 ABC transporter signature motif; other site 511437004083 Walker B; other site 511437004084 D-loop; other site 511437004085 H-loop/switch region; other site 511437004086 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511437004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004088 dimer interface [polypeptide binding]; other site 511437004089 conserved gate region; other site 511437004090 putative PBP binding loops; other site 511437004091 ABC-ATPase subunit interface; other site 511437004092 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 511437004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004094 dimer interface [polypeptide binding]; other site 511437004095 conserved gate region; other site 511437004096 putative PBP binding loops; other site 511437004097 ABC-ATPase subunit interface; other site 511437004098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437004099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 511437004100 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 511437004101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437004102 dimer interface [polypeptide binding]; other site 511437004103 phosphorylation site [posttranslational modification] 511437004104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437004105 ATP binding site [chemical binding]; other site 511437004106 Mg2+ binding site [ion binding]; other site 511437004107 G-X-G motif; other site 511437004108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437004109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437004110 active site 511437004111 phosphorylation site [posttranslational modification] 511437004112 intermolecular recognition site; other site 511437004113 dimerization interface [polypeptide binding]; other site 511437004114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437004115 DNA binding site [nucleotide binding] 511437004116 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 511437004117 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511437004118 peptide chain release factor 2; Validated; Region: prfB; PRK00578 511437004119 RF-1 domain; Region: RF-1; cl02875 511437004120 RF-1 domain; Region: RF-1; cl02875 511437004121 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 511437004122 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 511437004123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004124 nucleotide binding region [chemical binding]; other site 511437004125 ATP-binding site [chemical binding]; other site 511437004126 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 511437004127 30S subunit binding site; other site 511437004128 comF family protein; Region: comF; TIGR00201 511437004129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004130 active site 511437004131 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 511437004132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004133 ATP binding site [chemical binding]; other site 511437004134 putative Mg++ binding site [ion binding]; other site 511437004135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004136 Uncharacterized conserved protein [Function unknown]; Region: COG1739 511437004137 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511437004138 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 511437004139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004140 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004141 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 511437004142 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511437004143 Mg++ binding site [ion binding]; other site 511437004144 putative catalytic motif [active] 511437004145 substrate binding site [chemical binding]; other site 511437004146 LrgA family; Region: LrgA; cl00608 511437004147 LrgB-like family; Region: LrgB; cl00596 511437004148 Amino acid permease; Region: AA_permease_2; pfam13520 511437004149 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511437004150 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511437004151 ring oligomerisation interface [polypeptide binding]; other site 511437004152 ATP/Mg binding site [chemical binding]; other site 511437004153 stacking interactions; other site 511437004154 hinge regions; other site 511437004155 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511437004156 oligomerisation interface [polypeptide binding]; other site 511437004157 mobile loop; other site 511437004158 roof hairpin; other site 511437004159 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 511437004160 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 511437004161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004162 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437004163 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437004164 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437004165 ABC transporter; Region: ABC_tran_2; pfam12848 511437004166 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437004167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437004168 Helix-turn-helix domains; Region: HTH; cl00088 511437004169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437004170 Helix-turn-helix domains; Region: HTH; cl00088 511437004171 putative transposase OrfB; Reviewed; Region: PHA02517 511437004172 HTH-like domain; Region: HTH_21; pfam13276 511437004173 Integrase core domain; Region: rve; cl01316 511437004174 Integrase core domain; Region: rve_3; cl15866 511437004175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004176 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004177 UGMP family protein; Validated; Region: PRK09604 511437004178 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 511437004179 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511437004180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437004181 Coenzyme A binding pocket [chemical binding]; other site 511437004182 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 511437004183 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 511437004184 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511437004185 active site 511437004186 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511437004187 active site 511437004188 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 511437004189 Predicted methyltransferases [General function prediction only]; Region: COG0313 511437004190 Protein of unknown function (DUF972); Region: DUF972; pfam06156 511437004191 DNA polymerase III subunit delta'; Validated; Region: PRK08058 511437004192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004193 Nitrogen regulatory protein P-II; Region: P-II; cl00412 511437004194 thymidylate kinase; Validated; Region: tmk; PRK00698 511437004195 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511437004196 TMP-binding site; other site 511437004197 ATP-binding site [chemical binding]; other site 511437004198 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 511437004199 recombination protein RecR; Reviewed; Region: recR; PRK00076 511437004200 RecR protein; Region: RecR; pfam02132 511437004201 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511437004202 putative active site [active] 511437004203 putative metal-binding site [ion binding]; other site 511437004204 tetramer interface [polypeptide binding]; other site 511437004205 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 511437004206 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 511437004207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004208 Walker A motif; other site 511437004209 ATP binding site [chemical binding]; other site 511437004210 Walker B motif; other site 511437004211 arginine finger; other site 511437004212 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 511437004213 nucleoside/Zn binding site; other site 511437004214 dimer interface [polypeptide binding]; other site 511437004215 catalytic motif [active] 511437004216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437004217 S-adenosylmethionine binding site [chemical binding]; other site 511437004218 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 511437004219 catalytic residues [active] 511437004220 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 511437004221 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 511437004222 Class I ribonucleotide reductase; Region: RNR_I; cd01679 511437004223 active site 511437004224 dimer interface [polypeptide binding]; other site 511437004225 catalytic residues [active] 511437004226 effector binding site; other site 511437004227 R2 peptide binding site; other site 511437004228 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 511437004229 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 511437004230 dimer interface [polypeptide binding]; other site 511437004231 putative radical transfer pathway; other site 511437004232 diiron center [ion binding]; other site 511437004233 tyrosyl radical; other site 511437004234 D-lactate dehydrogenase; Validated; Region: PRK08605 511437004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004236 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 511437004237 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 511437004238 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 511437004239 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 511437004240 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511437004241 NAD binding site [chemical binding]; other site 511437004242 homodimer interface [polypeptide binding]; other site 511437004243 active site 511437004244 substrate binding site [chemical binding]; other site 511437004245 galactokinase; Provisional; Region: PRK05322 511437004246 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 511437004247 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004248 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004249 Predicted integral membrane protein [Function unknown]; Region: COG0392 511437004250 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 511437004251 Uncharacterized conserved protein [Function unknown]; Region: COG2898 511437004252 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 511437004253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004254 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004255 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437004256 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437004257 active site 511437004258 Baseplate J-like protein; Region: Baseplate_J; cl01294 511437004259 electron transport complex protein RnfC; Provisional; Region: PRK05035 511437004260 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 511437004261 Peptidase family M23; Region: Peptidase_M23; pfam01551 511437004262 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437004263 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 511437004264 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 511437004265 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 511437004266 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 511437004267 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 511437004268 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 511437004269 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 511437004270 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 511437004271 putative peptidoglycan binding site; other site 511437004272 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 511437004273 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 511437004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 511437004275 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 511437004276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 511437004277 Terminase-like family; Region: Terminase_6; pfam03237 511437004278 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 511437004279 Helix-turn-helix domains; Region: HTH; cl00088 511437004280 YopX protein; Region: YopX; cl09859 511437004281 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 511437004282 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 511437004283 AntA/AntB antirepressor; Region: AntA; cl01430 511437004284 ORF6C domain; Region: ORF6C; pfam10552 511437004285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004286 Walker A motif; other site 511437004287 ATP binding site [chemical binding]; other site 511437004288 Walker B motif; other site 511437004289 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 511437004290 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 511437004291 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 511437004292 RecT family; Region: RecT; cl04285 511437004293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004294 non-specific DNA binding site [nucleotide binding]; other site 511437004295 salt bridge; other site 511437004296 sequence-specific DNA binding site [nucleotide binding]; other site 511437004297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004298 non-specific DNA binding site [nucleotide binding]; other site 511437004299 salt bridge; other site 511437004300 sequence-specific DNA binding site [nucleotide binding]; other site 511437004301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004302 non-specific DNA binding site [nucleotide binding]; other site 511437004303 salt bridge; other site 511437004304 sequence-specific DNA binding site [nucleotide binding]; other site 511437004305 Domain of unknown function (DUF955); Region: DUF955; cl01076 511437004306 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511437004307 DNA binding site [nucleotide binding] 511437004308 Int/Topo IB signature motif; other site 511437004309 active site 511437004310 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511437004311 peripheral dimer interface [polypeptide binding]; other site 511437004312 core dimer interface [polypeptide binding]; other site 511437004313 L10 interface [polypeptide binding]; other site 511437004314 L11 interface [polypeptide binding]; other site 511437004315 putative EF-Tu interaction site [polypeptide binding]; other site 511437004316 putative EF-G interaction site [polypeptide binding]; other site 511437004317 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511437004318 23S rRNA interface [nucleotide binding]; other site 511437004319 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511437004320 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511437004321 mRNA/rRNA interface [nucleotide binding]; other site 511437004322 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 511437004323 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511437004324 23S rRNA interface [nucleotide binding]; other site 511437004325 L7/L12 interface [polypeptide binding]; other site 511437004326 putative thiostrepton binding site; other site 511437004327 L25 interface [polypeptide binding]; other site 511437004328 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437004329 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511437004330 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511437004331 putative homodimer interface [polypeptide binding]; other site 511437004332 KOW motif; Region: KOW; cl00354 511437004333 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 511437004334 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 511437004335 RNA polymerase factor sigma-70; Validated; Region: PRK08295 511437004336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511437004337 YacP-like NYN domain; Region: NYN_YacP; cl01491 511437004338 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 511437004339 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 511437004340 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 511437004341 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 511437004342 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511437004343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511437004344 active site 511437004345 HIGH motif; other site 511437004346 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511437004347 KMSKS motif; other site 511437004348 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511437004349 tRNA binding surface [nucleotide binding]; other site 511437004350 anticodon binding site; other site 511437004351 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437004352 Helix-turn-helix domains; Region: HTH; cl00088 511437004353 Integrase core domain; Region: rve; cl01316 511437004354 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511437004355 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437004356 active site 511437004357 HIGH motif; other site 511437004358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511437004359 active site 511437004360 KMSKS motif; other site 511437004361 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 511437004362 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 511437004363 putative active site [active] 511437004364 DNA repair protein RadA; Provisional; Region: PRK11823 511437004365 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 511437004366 Walker A motif/ATP binding site; other site 511437004367 ATP binding site [chemical binding]; other site 511437004368 Walker B motif; other site 511437004369 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 511437004370 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511437004371 trimer interface [polypeptide binding]; other site 511437004372 active site 511437004373 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511437004374 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437004375 active site 511437004376 dimer interface [polypeptide binding]; other site 511437004377 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 511437004378 trimer interface [polypeptide binding]; other site 511437004379 active site 511437004380 G bulge; other site 511437004381 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437004382 catalytic core [active] 511437004383 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437004384 Membrane transport protein; Region: Mem_trans; cl09117 511437004385 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 511437004386 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 511437004387 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 511437004388 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 511437004389 active site 511437004390 phosphorylation site [posttranslational modification] 511437004391 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 511437004392 active pocket/dimerization site; other site 511437004393 active site 511437004394 phosphorylation site [posttranslational modification] 511437004395 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511437004396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004397 active site 511437004398 motif I; other site 511437004399 motif II; other site 511437004400 homoserine kinase; Provisional; Region: PRK01212 511437004401 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004402 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004403 hypothetical protein; Provisional; Region: PRK04351 511437004404 SprT homologues; Region: SprT; cl01182 511437004405 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 511437004406 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 511437004407 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 511437004408 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 511437004409 RNA binding site [nucleotide binding]; other site 511437004410 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511437004411 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437004412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437004413 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437004414 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437004415 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437004416 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 511437004417 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511437004418 homodimer interface [polypeptide binding]; other site 511437004419 NAD binding pocket [chemical binding]; other site 511437004420 ATP binding pocket [chemical binding]; other site 511437004421 Mg binding site [ion binding]; other site 511437004422 active-site loop [active] 511437004423 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 511437004424 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 511437004425 active site 511437004426 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511437004427 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511437004428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437004429 DNA-binding site [nucleotide binding]; DNA binding site 511437004430 UTRA domain; Region: UTRA; cl01230 511437004431 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511437004432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004433 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 511437004434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004435 putative substrate translocation pore; other site 511437004436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 511437004437 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 511437004438 methionine cluster; other site 511437004439 active site 511437004440 phosphorylation site [posttranslational modification] 511437004441 metal binding site [ion binding]; metal-binding site 511437004442 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 511437004443 P-loop; other site 511437004444 active site 511437004445 phosphorylation site [posttranslational modification] 511437004446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004447 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004448 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437004449 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437004450 active site 511437004451 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 511437004452 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 511437004453 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 511437004454 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 511437004455 NlpC/P60 family; Region: NLPC_P60; cl11438 511437004456 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437004457 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 511437004458 Phage major tail protein; Region: Phage_tail; pfam04630 511437004459 Protein of unknown function (DUF806); Region: DUF806; pfam05657 511437004460 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 511437004461 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 511437004462 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 511437004463 Phage capsid family; Region: Phage_capsid; pfam05065 511437004464 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 511437004465 oligomer interface [polypeptide binding]; other site 511437004466 active site residues [active] 511437004467 Phage-related protein [Function unknown]; Region: COG4695; cl01923 511437004468 Phage portal protein; Region: Phage_portal; pfam04860 511437004469 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 511437004470 Phage Terminase; Region: Terminase_1; pfam03354 511437004471 Phage terminase, small subunit; Region: Terminase_4; cl01525 511437004472 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511437004473 active site 511437004474 YopX protein; Region: YopX; cl09859 511437004475 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 511437004476 Uncharacterized conserved protein [Function unknown]; Region: COG4983 511437004477 hypothetical protein; Provisional; Region: PRK14709 511437004478 D5 N terminal like; Region: D5_N; cl07360 511437004479 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 511437004480 Protein of unknown function (DUF669); Region: DUF669; pfam05037 511437004481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004482 ATP binding site [chemical binding]; other site 511437004483 putative Mg++ binding site [ion binding]; other site 511437004484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004485 nucleotide binding region [chemical binding]; other site 511437004486 ATP-binding site [chemical binding]; other site 511437004487 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511437004488 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 511437004489 AAA domain; Region: AAA_24; pfam13479 511437004490 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 511437004491 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 511437004492 Domain of unknown function (DUF771); Region: DUF771; cl09962 511437004493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004494 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 511437004495 non-specific DNA binding site [nucleotide binding]; other site 511437004496 salt bridge; other site 511437004497 sequence-specific DNA binding site [nucleotide binding]; other site 511437004498 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511437004499 Catalytic site [active] 511437004500 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 511437004501 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511437004502 Int/Topo IB signature motif; other site 511437004503 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511437004504 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511437004505 dimer interface [polypeptide binding]; other site 511437004506 putative anticodon binding site; other site 511437004507 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511437004508 motif 1; other site 511437004509 active site 511437004510 motif 2; other site 511437004511 motif 3; other site 511437004512 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 511437004513 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511437004514 FMN binding site [chemical binding]; other site 511437004515 active site 511437004516 catalytic residues [active] 511437004517 substrate binding site [chemical binding]; other site 511437004518 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 511437004519 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 511437004520 dimerization interface [polypeptide binding]; other site 511437004521 domain crossover interface; other site 511437004522 redox-dependent activation switch; other site 511437004523 FtsH Extracellular; Region: FtsH_ext; pfam06480 511437004524 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 511437004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004526 Walker A motif; other site 511437004527 ATP binding site [chemical binding]; other site 511437004528 Walker B motif; other site 511437004529 arginine finger; other site 511437004530 Peptidase family M41; Region: Peptidase_M41; pfam01434 511437004531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004532 active site 511437004533 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511437004534 Ligand Binding Site [chemical binding]; other site 511437004535 B3/4 domain; Region: B3_4; cl11458 511437004536 hypothetical protein; Provisional; Region: PRK08582 511437004537 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 511437004538 RNA binding site [nucleotide binding]; other site 511437004539 Septum formation initiator; Region: DivIC; cl11433 511437004540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511437004541 RNA binding surface [nucleotide binding]; other site 511437004542 MatE; Region: MatE; cl10513 511437004543 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511437004544 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 511437004545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437004546 ATP binding site [chemical binding]; other site 511437004547 putative Mg++ binding site [ion binding]; other site 511437004548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004549 nucleotide binding region [chemical binding]; other site 511437004550 ATP-binding site [chemical binding]; other site 511437004551 TRCF domain; Region: TRCF; cl04088 511437004552 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511437004553 putative active site [active] 511437004554 catalytic residue [active] 511437004555 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 511437004556 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 511437004557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511437004558 NAD binding site [chemical binding]; other site 511437004559 dimer interface [polypeptide binding]; other site 511437004560 substrate binding site [chemical binding]; other site 511437004561 FOG: CBS domain [General function prediction only]; Region: COG0517 511437004562 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 511437004563 PemK-like protein; Region: PemK; cl00995 511437004564 alanine racemase; Reviewed; Region: alr; PRK00053 511437004565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511437004566 active site 511437004567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511437004568 dimer interface [polypeptide binding]; other site 511437004569 substrate binding site [chemical binding]; other site 511437004570 catalytic residues [active] 511437004571 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 511437004572 helicase 45; Provisional; Region: PTZ00424 511437004573 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511437004574 ATP binding site [chemical binding]; other site 511437004575 Mg++ binding site [ion binding]; other site 511437004576 motif III; other site 511437004577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004578 nucleotide binding region [chemical binding]; other site 511437004579 ATP-binding site [chemical binding]; other site 511437004580 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 511437004581 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511437004582 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511437004583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511437004584 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511437004585 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 511437004586 active site 511437004587 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 511437004588 active site 511437004589 catalytic site [active] 511437004590 drug efflux system protein MdtG; Provisional; Region: PRK09874 511437004591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437004592 putative substrate translocation pore; other site 511437004593 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 511437004594 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511437004595 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511437004596 hinge; other site 511437004597 active site 511437004598 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 511437004599 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 511437004600 Protein export membrane protein; Region: SecD_SecF; cl14618 511437004601 CTP synthetase; Validated; Region: pyrG; PRK05380 511437004602 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511437004603 Catalytic site [active] 511437004604 active site 511437004605 UTP binding site [chemical binding]; other site 511437004606 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511437004607 active site 511437004608 putative oxyanion hole; other site 511437004609 catalytic triad [active] 511437004610 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 511437004611 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 511437004612 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511437004613 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437004614 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 511437004615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437004616 Zn2+ binding site [ion binding]; other site 511437004617 Mg2+ binding site [ion binding]; other site 511437004618 sugar phosphate phosphatase; Provisional; Region: PRK10513 511437004619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437004620 active site 511437004621 motif I; other site 511437004622 motif II; other site 511437004623 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437004624 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 511437004625 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511437004626 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511437004627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004628 active site 511437004629 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 511437004630 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511437004631 Substrate binding site; other site 511437004632 Mg++ binding site; other site 511437004633 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511437004634 active site 511437004635 substrate binding site [chemical binding]; other site 511437004636 CoA binding site [chemical binding]; other site 511437004637 pur operon repressor; Provisional; Region: PRK09213 511437004638 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 511437004639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004640 active site 511437004641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 511437004642 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511437004643 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 511437004644 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 511437004645 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437004646 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511437004647 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 511437004648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004649 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 511437004650 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 511437004651 putative active site [active] 511437004652 putative metal binding site [ion binding]; other site 511437004653 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 511437004654 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511437004655 active site 511437004656 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 511437004657 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511437004658 active site 511437004659 HIGH motif; other site 511437004660 KMSKS motif; other site 511437004661 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511437004662 tRNA binding surface [nucleotide binding]; other site 511437004663 anticodon binding site; other site 511437004664 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511437004665 dimer interface [polypeptide binding]; other site 511437004666 putative tRNA-binding site [nucleotide binding]; other site 511437004667 Protein of unknown function DUF72; Region: DUF72; cl00777 511437004668 NAD-dependent deacetylase; Provisional; Region: PRK00481 511437004669 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 511437004670 NAD+ binding site [chemical binding]; other site 511437004671 substrate binding site [chemical binding]; other site 511437004672 putative Zn binding site [ion binding]; other site 511437004673 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 511437004674 homodimer interface [polypeptide binding]; other site 511437004675 NAD binding site [chemical binding]; other site 511437004676 catalytic residues [active] 511437004677 substrate binding pocket [chemical binding]; other site 511437004678 flexible flap; other site 511437004679 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 511437004680 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511437004681 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511437004682 active site 511437004683 HIGH motif; other site 511437004684 dimer interface [polypeptide binding]; other site 511437004685 KMSKS motif; other site 511437004686 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511437004687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004688 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 511437004689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004690 Family description; Region: UvrD_C_2; cl15862 511437004691 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 511437004692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437004694 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437004695 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511437004696 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511437004697 substrate binding pocket [chemical binding]; other site 511437004698 chain length determination region; other site 511437004699 substrate-Mg2+ binding site; other site 511437004700 catalytic residues [active] 511437004701 aspartate-rich region 1; other site 511437004702 active site lid residues [active] 511437004703 aspartate-rich region 2; other site 511437004704 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 511437004705 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437004706 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 511437004707 Walker A/P-loop; other site 511437004708 ATP binding site [chemical binding]; other site 511437004709 Q-loop/lid; other site 511437004710 ABC transporter signature motif; other site 511437004711 Walker B; other site 511437004712 D-loop; other site 511437004713 H-loop/switch region; other site 511437004714 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 511437004715 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437004716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004717 Walker A/P-loop; other site 511437004718 ATP binding site [chemical binding]; other site 511437004719 Q-loop/lid; other site 511437004720 ABC transporter signature motif; other site 511437004721 Walker B; other site 511437004722 D-loop; other site 511437004723 H-loop/switch region; other site 511437004724 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 511437004725 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 511437004726 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 511437004727 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 511437004728 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 511437004729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511437004731 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511437004732 Walker A/P-loop; other site 511437004733 ATP binding site [chemical binding]; other site 511437004734 Q-loop/lid; other site 511437004735 ABC transporter signature motif; other site 511437004736 Walker B; other site 511437004737 D-loop; other site 511437004738 H-loop/switch region; other site 511437004739 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 511437004740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511437004741 ABC-ATPase subunit interface; other site 511437004742 dimer interface [polypeptide binding]; other site 511437004743 putative PBP binding regions; other site 511437004744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511437004745 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511437004746 intersubunit interface [polypeptide binding]; other site 511437004747 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 511437004748 heme-binding site [chemical binding]; other site 511437004749 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 511437004750 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 511437004751 heme-binding site [chemical binding]; other site 511437004752 Gram positive anchor; Region: Gram_pos_anchor; cl15427 511437004753 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511437004754 Sulfatase; Region: Sulfatase; cl10460 511437004755 Predicted integral membrane protein [Function unknown]; Region: COG0392 511437004756 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 511437004757 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511437004758 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511437004759 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 511437004760 putative ADP-binding pocket [chemical binding]; other site 511437004761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437004762 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437004763 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511437004764 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 511437004765 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 511437004766 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 511437004767 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511437004768 dimerization domain swap beta strand [polypeptide binding]; other site 511437004769 regulatory protein interface [polypeptide binding]; other site 511437004770 active site 511437004771 regulatory phosphorylation site [posttranslational modification]; other site 511437004772 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 511437004773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004774 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437004775 Walker A motif; other site 511437004776 ATP binding site [chemical binding]; other site 511437004777 Walker B motif; other site 511437004778 arginine finger; other site 511437004779 UvrB/uvrC motif; Region: UVR; pfam02151 511437004780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437004781 Walker A motif; other site 511437004782 ATP binding site [chemical binding]; other site 511437004783 Walker B motif; other site 511437004784 arginine finger; other site 511437004785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437004786 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437004787 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437004788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437004789 non-specific DNA binding site [nucleotide binding]; other site 511437004790 salt bridge; other site 511437004791 sequence-specific DNA binding site [nucleotide binding]; other site 511437004792 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 511437004793 Peptidase family C69; Region: Peptidase_C69; pfam03577 511437004794 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 511437004795 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 511437004796 G1 box; other site 511437004797 putative GEF interaction site [polypeptide binding]; other site 511437004798 GTP/Mg2+ binding site [chemical binding]; other site 511437004799 Switch I region; other site 511437004800 G2 box; other site 511437004801 G3 box; other site 511437004802 Switch II region; other site 511437004803 G4 box; other site 511437004804 G5 box; other site 511437004805 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 511437004806 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 511437004807 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 511437004808 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 511437004809 active site 511437004810 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511437004811 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 511437004812 Protein of unknown function (DUF402); Region: DUF402; cl00979 511437004813 RecX family; Region: RecX; cl00936 511437004814 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437004815 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 511437004816 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 511437004817 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511437004818 active site 511437004819 homodimer interface [polypeptide binding]; other site 511437004820 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511437004821 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511437004822 Ligand binding site; other site 511437004823 Putative Catalytic site; other site 511437004824 DXD motif; other site 511437004825 Photosystem II protein; Region: PSII; cl08223 511437004826 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 511437004827 GtrA-like protein; Region: GtrA; cl00971 511437004828 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004830 dimer interface [polypeptide binding]; other site 511437004831 conserved gate region; other site 511437004832 putative PBP binding loops; other site 511437004833 ABC-ATPase subunit interface; other site 511437004834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437004835 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437004836 substrate binding pocket [chemical binding]; other site 511437004837 membrane-bound complex binding site; other site 511437004838 hinge residues; other site 511437004839 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437004840 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437004841 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 511437004842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004843 ATP binding site [chemical binding]; other site 511437004844 putative Mg++ binding site [ion binding]; other site 511437004845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437004846 nucleotide binding region [chemical binding]; other site 511437004847 ATP-binding site [chemical binding]; other site 511437004848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511437004849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004850 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 511437004851 active site 511437004852 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 511437004853 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511437004854 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511437004855 putative active site [active] 511437004856 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 511437004857 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 511437004858 N- and C-terminal domain interface [polypeptide binding]; other site 511437004859 putative active site [active] 511437004860 catalytic site [active] 511437004861 metal binding site [ion binding]; metal-binding site 511437004862 carbohydrate binding site [chemical binding]; other site 511437004863 ATP binding site [chemical binding]; other site 511437004864 GntP family permease; Region: GntP_permease; pfam02447 511437004865 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 511437004866 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511437004867 Helix-turn-helix domains; Region: HTH; cl00088 511437004868 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 511437004869 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437004870 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 511437004871 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 511437004872 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 511437004873 NAD binding site [chemical binding]; other site 511437004874 homotetramer interface [polypeptide binding]; other site 511437004875 homodimer interface [polypeptide binding]; other site 511437004876 substrate binding site [chemical binding]; other site 511437004877 active site 511437004878 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511437004879 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 511437004880 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 511437004881 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511437004882 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511437004883 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437004884 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 511437004885 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511437004886 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511437004887 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511437004888 carboxyltransferase (CT) interaction site; other site 511437004889 biotinylation site [posttranslational modification]; other site 511437004890 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 511437004891 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511437004892 dimer interface [polypeptide binding]; other site 511437004893 active site 511437004894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437004895 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 511437004896 NAD(P) binding site [chemical binding]; other site 511437004897 active site 511437004898 Acyl transferase domain; Region: Acyl_transf_1; cl08282 511437004899 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511437004900 Phosphopantetheine attachment site; Region: PP-binding; cl09936 511437004901 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511437004902 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511437004903 dimer interface [polypeptide binding]; other site 511437004904 active site 511437004905 CoA binding pocket [chemical binding]; other site 511437004906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437004907 Helix-turn-helix domains; Region: HTH; cl00088 511437004908 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511437004909 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 511437004910 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511437004911 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511437004912 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 511437004913 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 511437004914 Helix-turn-helix domains; Region: HTH; cl00088 511437004915 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 511437004916 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511437004917 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 511437004918 Sulfatase; Region: Sulfatase; cl10460 511437004919 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 511437004920 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511437004921 intersubunit interface [polypeptide binding]; other site 511437004922 active site 511437004923 catalytic residue [active] 511437004924 NMT1-like family; Region: NMT1_2; cl15260 511437004925 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511437004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437004927 dimer interface [polypeptide binding]; other site 511437004928 conserved gate region; other site 511437004929 putative PBP binding loops; other site 511437004930 ABC-ATPase subunit interface; other site 511437004931 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 511437004932 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 511437004933 Walker A/P-loop; other site 511437004934 ATP binding site [chemical binding]; other site 511437004935 Q-loop/lid; other site 511437004936 ABC transporter signature motif; other site 511437004937 Walker B; other site 511437004938 D-loop; other site 511437004939 H-loop/switch region; other site 511437004940 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511437004941 TRAM domain; Region: TRAM; cl01282 511437004942 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 511437004943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437004944 S-adenosylmethionine binding site [chemical binding]; other site 511437004945 putative lipid kinase; Reviewed; Region: PRK13055 511437004946 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 511437004947 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 511437004948 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 511437004949 GatB domain; Region: GatB_Yqey; cl11497 511437004950 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 511437004951 Amidase; Region: Amidase; cl11426 511437004952 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 511437004953 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 511437004954 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511437004955 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511437004956 nucleotide binding pocket [chemical binding]; other site 511437004957 K-X-D-G motif; other site 511437004958 catalytic site [active] 511437004959 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511437004960 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511437004961 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511437004962 Dimer interface [polypeptide binding]; other site 511437004963 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511437004964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437004965 Family description; Region: UvrD_C_2; cl15862 511437004966 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 511437004967 ATP-grasp domain; Region: ATP-grasp_4; cl03087 511437004968 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 511437004969 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437004970 active site 511437004971 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 511437004972 Predicted membrane protein [Function unknown]; Region: COG4684 511437004973 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 511437004974 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511437004975 23S rRNA interface [nucleotide binding]; other site 511437004976 L3 interface [polypeptide binding]; other site 511437004977 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511437004978 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 511437004979 dimerization interface 3.5A [polypeptide binding]; other site 511437004980 active site 511437004981 Cobalt transport protein; Region: CbiQ; cl00463 511437004982 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 511437004983 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437004984 Walker A/P-loop; other site 511437004985 ATP binding site [chemical binding]; other site 511437004986 Q-loop/lid; other site 511437004987 ABC transporter signature motif; other site 511437004988 Walker B; other site 511437004989 D-loop; other site 511437004990 H-loop/switch region; other site 511437004991 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 511437004992 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437004993 Walker A/P-loop; other site 511437004994 ATP binding site [chemical binding]; other site 511437004995 Q-loop/lid; other site 511437004996 ABC transporter signature motif; other site 511437004997 Walker B; other site 511437004998 D-loop; other site 511437004999 H-loop/switch region; other site 511437005000 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 511437005001 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511437005002 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511437005003 alphaNTD homodimer interface [polypeptide binding]; other site 511437005004 alphaNTD - beta interaction site [polypeptide binding]; other site 511437005005 alphaNTD - beta' interaction site [polypeptide binding]; other site 511437005006 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 511437005007 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 511437005008 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 511437005009 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 511437005010 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 511437005011 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511437005012 rRNA binding site [nucleotide binding]; other site 511437005013 predicted 30S ribosome binding site; other site 511437005014 adenylate kinase; Reviewed; Region: adk; PRK00279 511437005015 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511437005016 AMP-binding site [chemical binding]; other site 511437005017 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511437005018 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511437005019 SecY translocase; Region: SecY; pfam00344 511437005020 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 511437005021 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 511437005022 23S rRNA binding site [nucleotide binding]; other site 511437005023 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511437005024 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511437005025 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511437005026 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511437005027 23S rRNA interface [nucleotide binding]; other site 511437005028 5S rRNA interface [nucleotide binding]; other site 511437005029 L27 interface [polypeptide binding]; other site 511437005030 L5 interface [polypeptide binding]; other site 511437005031 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511437005032 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511437005033 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511437005034 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 511437005035 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 511437005036 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511437005037 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511437005038 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511437005039 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511437005040 KOW motif; Region: KOW; cl00354 511437005041 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 511437005042 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 511437005043 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511437005044 23S rRNA interface [nucleotide binding]; other site 511437005045 putative translocon interaction site; other site 511437005046 signal recognition particle (SRP54) interaction site; other site 511437005047 L23 interface [polypeptide binding]; other site 511437005048 trigger factor interaction site; other site 511437005049 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511437005050 23S rRNA interface [nucleotide binding]; other site 511437005051 5S rRNA interface [nucleotide binding]; other site 511437005052 putative antibiotic binding site [chemical binding]; other site 511437005053 L25 interface [polypeptide binding]; other site 511437005054 L27 interface [polypeptide binding]; other site 511437005055 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 511437005056 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511437005057 G-X-X-G motif; other site 511437005058 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511437005059 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511437005060 putative translocon binding site; other site 511437005061 protein-rRNA interface [nucleotide binding]; other site 511437005062 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 511437005063 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511437005064 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511437005065 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511437005066 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 511437005067 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 511437005068 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 511437005069 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 511437005070 elongation factor G; Reviewed; Region: PRK12739 511437005071 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511437005072 G1 box; other site 511437005073 putative GEF interaction site [polypeptide binding]; other site 511437005074 GTP/Mg2+ binding site [chemical binding]; other site 511437005075 Switch I region; other site 511437005076 G2 box; other site 511437005077 G3 box; other site 511437005078 Switch II region; other site 511437005079 G4 box; other site 511437005080 G5 box; other site 511437005081 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511437005082 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511437005083 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511437005084 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 511437005085 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511437005086 S17 interaction site [polypeptide binding]; other site 511437005087 S8 interaction site; other site 511437005088 16S rRNA interaction site [nucleotide binding]; other site 511437005089 streptomycin interaction site [chemical binding]; other site 511437005090 23S rRNA interaction site [nucleotide binding]; other site 511437005091 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511437005092 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511437005093 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511437005094 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 511437005095 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511437005096 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 511437005097 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511437005098 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511437005099 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 511437005100 cleft; other site 511437005101 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 511437005102 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511437005103 DNA binding site [nucleotide binding] 511437005104 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511437005105 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 511437005106 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 511437005107 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 511437005108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511437005109 RPB1 interaction site [polypeptide binding]; other site 511437005110 RPB10 interaction site [polypeptide binding]; other site 511437005111 RPB11 interaction site [polypeptide binding]; other site 511437005112 RPB3 interaction site [polypeptide binding]; other site 511437005113 RPB12 interaction site [polypeptide binding]; other site 511437005114 Clp protease ATP binding subunit; Region: clpC; CHL00095 511437005115 Clp amino terminal domain; Region: Clp_N; pfam02861 511437005116 Clp amino terminal domain; Region: Clp_N; pfam02861 511437005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437005118 Walker A motif; other site 511437005119 ATP binding site [chemical binding]; other site 511437005120 Walker B motif; other site 511437005121 arginine finger; other site 511437005122 UvrB/uvrC motif; Region: UVR; pfam02151 511437005123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437005124 Walker A motif; other site 511437005125 ATP binding site [chemical binding]; other site 511437005126 Walker B motif; other site 511437005127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437005128 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 511437005129 seryl-tRNA synthetase; Provisional; Region: PRK05431 511437005130 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511437005131 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 511437005132 dimer interface [polypeptide binding]; other site 511437005133 active site 511437005134 motif 1; other site 511437005135 motif 2; other site 511437005136 motif 3; other site 511437005137 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511437005138 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511437005139 Substrate-binding site [chemical binding]; other site 511437005140 Substrate specificity [chemical binding]; other site 511437005141 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 511437005142 lysine transporter; Provisional; Region: PRK10836 511437005143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511437005144 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437005145 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437005146 active site 511437005147 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005148 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 511437005149 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 511437005150 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 511437005151 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 511437005152 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 511437005153 Helix-turn-helix domains; Region: HTH; cl00088 511437005154 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437005155 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437005156 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437005157 Helix-turn-helix domains; Region: HTH; cl00088 511437005158 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511437005159 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511437005160 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437005161 Cation efflux family; Region: Cation_efflux; cl00316 511437005162 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437005163 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 511437005164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005165 DNA binding residues [nucleotide binding] 511437005166 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005167 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005168 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 511437005169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437005170 non-specific DNA binding site [nucleotide binding]; other site 511437005171 salt bridge; other site 511437005172 sequence-specific DNA binding site [nucleotide binding]; other site 511437005173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005174 Coenzyme A binding pocket [chemical binding]; other site 511437005175 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 511437005176 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437005177 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 511437005178 active site 511437005179 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 511437005180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005181 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005182 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 511437005183 chromosome segregation protein; Provisional; Region: PRK03918 511437005184 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 511437005185 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 511437005186 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511437005187 inhibitor-cofactor binding pocket; inhibition site 511437005188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005189 catalytic residue [active] 511437005190 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 511437005191 nucleotide binding site [chemical binding]; other site 511437005192 N-acetyl-L-glutamate binding site [chemical binding]; other site 511437005193 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 511437005194 heterotetramer interface [polypeptide binding]; other site 511437005195 active site pocket [active] 511437005196 cleavage site 511437005197 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 511437005198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005199 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511437005200 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 511437005201 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437005202 homodimer interface [polypeptide binding]; other site 511437005203 substrate-cofactor binding pocket; other site 511437005204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005205 catalytic residue [active] 511437005206 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 511437005207 proposed active site lysine [active] 511437005208 conserved cys residue [active] 511437005209 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437005210 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437005211 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437005212 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 511437005213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005216 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437005217 NAD(P) binding site [chemical binding]; other site 511437005218 active site 511437005219 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 511437005220 Cupin domain; Region: Cupin_2; cl09118 511437005221 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437005222 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005223 DNA binding residues [nucleotide binding] 511437005224 putative dimer interface [polypeptide binding]; other site 511437005225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437005226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511437005227 active site 511437005228 phosphorylation site [posttranslational modification] 511437005229 intermolecular recognition site; other site 511437005230 dimerization interface [polypeptide binding]; other site 511437005231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437005232 DNA binding site [nucleotide binding] 511437005233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511437005234 dimer interface [polypeptide binding]; other site 511437005235 phosphorylation site [posttranslational modification] 511437005236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511437005237 ATP binding site [chemical binding]; other site 511437005238 Mg2+ binding site [ion binding]; other site 511437005239 G-X-G motif; other site 511437005240 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511437005241 active site 511437005242 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437005243 EamA-like transporter family; Region: EamA; cl01037 511437005244 EamA-like transporter family; Region: EamA; cl01037 511437005245 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 511437005246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437005247 S-adenosylmethionine binding site [chemical binding]; other site 511437005248 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511437005249 DNA binding residues [nucleotide binding] 511437005250 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005251 putative dimer interface [polypeptide binding]; other site 511437005252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005254 putative substrate translocation pore; other site 511437005255 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 511437005256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005258 homodimer interface [polypeptide binding]; other site 511437005259 catalytic residue [active] 511437005260 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 511437005261 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 511437005262 active site 511437005263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005264 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437005265 putative substrate translocation pore; other site 511437005266 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 511437005267 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437005268 catalytic Zn binding site [ion binding]; other site 511437005269 NAD(P) binding site [chemical binding]; other site 511437005270 structural Zn binding site [ion binding]; other site 511437005271 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511437005272 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 511437005273 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511437005274 Gram positive anchor; Region: Gram_pos_anchor; cl15427 511437005275 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 511437005276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437005277 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437005278 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 511437005279 Helix-turn-helix domains; Region: HTH; cl00088 511437005280 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511437005281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005282 Coenzyme A binding pocket [chemical binding]; other site 511437005283 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 511437005284 active site 511437005285 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437005286 Peptidase family M1; Region: Peptidase_M1; pfam01433 511437005287 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 511437005288 Zn binding site [ion binding]; other site 511437005289 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 511437005290 short chain dehydrogenase; Validated; Region: PRK06182 511437005291 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511437005292 NADP binding site [chemical binding]; other site 511437005293 active site 511437005294 steroid binding site; other site 511437005295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437005296 Helix-turn-helix domains; Region: HTH; cl00088 511437005297 Predicted membrane protein [Function unknown]; Region: COG2364 511437005298 Sugar transport protein; Region: Sugar_transport; pfam06800 511437005299 Predicted membrane protein [Function unknown]; Region: COG1511 511437005300 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437005301 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437005302 Predicted membrane protein [Function unknown]; Region: COG1511 511437005303 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511437005304 ABC-2 type transporter; Region: ABC2_membrane; cl11417 511437005305 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511437005306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437005307 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511437005308 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 511437005309 GMP synthase; Reviewed; Region: guaA; PRK00074 511437005310 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 511437005311 AMP/PPi binding site [chemical binding]; other site 511437005312 candidate oxyanion hole; other site 511437005313 catalytic triad [active] 511437005314 potential glutamine specificity residues [chemical binding]; other site 511437005315 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 511437005316 ATP Binding subdomain [chemical binding]; other site 511437005317 Dimerization subdomain; other site 511437005318 pantothenate kinase; Provisional; Region: PRK05439 511437005319 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 511437005320 ATP-binding site [chemical binding]; other site 511437005321 CoA-binding site [chemical binding]; other site 511437005322 Mg2+-binding site [ion binding]; other site 511437005323 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 511437005324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005325 Family description; Region: UvrD_C_2; cl15862 511437005326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005327 catalytic core [active] 511437005328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005329 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 511437005330 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437005331 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005332 DNA binding residues [nucleotide binding] 511437005333 putative dimer interface [polypeptide binding]; other site 511437005334 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437005335 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437005336 active site 511437005337 substrate binding site [chemical binding]; other site 511437005338 trimer interface [polypeptide binding]; other site 511437005339 CoA binding site [chemical binding]; other site 511437005340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005341 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005342 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511437005343 DNA binding residues [nucleotide binding] 511437005344 putative dimer interface [polypeptide binding]; other site 511437005345 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511437005346 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511437005347 Walker A/P-loop; other site 511437005348 ATP binding site [chemical binding]; other site 511437005349 Q-loop/lid; other site 511437005350 ABC transporter signature motif; other site 511437005351 Walker B; other site 511437005352 D-loop; other site 511437005353 H-loop/switch region; other site 511437005354 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437005355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511437005356 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511437005357 Walker A/P-loop; other site 511437005358 ATP binding site [chemical binding]; other site 511437005359 Q-loop/lid; other site 511437005360 ABC transporter signature motif; other site 511437005361 Walker B; other site 511437005362 D-loop; other site 511437005363 H-loop/switch region; other site 511437005364 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437005365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005366 dimer interface [polypeptide binding]; other site 511437005367 conserved gate region; other site 511437005368 putative PBP binding loops; other site 511437005369 ABC-ATPase subunit interface; other site 511437005370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511437005371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005372 dimer interface [polypeptide binding]; other site 511437005373 ABC-ATPase subunit interface; other site 511437005374 putative PBP binding loops; other site 511437005375 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437005376 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437005377 peptide binding site [polypeptide binding]; other site 511437005378 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 511437005379 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511437005380 HflX GTPase family; Region: HflX; cd01878 511437005381 G1 box; other site 511437005382 GTP/Mg2+ binding site [chemical binding]; other site 511437005383 Switch I region; other site 511437005384 G2 box; other site 511437005385 G3 box; other site 511437005386 Switch II region; other site 511437005387 G4 box; other site 511437005388 G5 box; other site 511437005389 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 511437005390 Spore germination protein; Region: Spore_permease; cl15802 511437005391 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437005392 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 511437005393 putative NAD(P) binding site [chemical binding]; other site 511437005394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437005395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437005396 DNA binding site [nucleotide binding] 511437005397 domain linker motif; other site 511437005398 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 511437005399 dimerization interface [polypeptide binding]; other site 511437005400 ligand binding site [chemical binding]; other site 511437005401 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 511437005402 MgtC family; Region: MgtC; pfam02308 511437005403 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437005404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005405 dimer interface [polypeptide binding]; other site 511437005406 conserved gate region; other site 511437005407 putative PBP binding loops; other site 511437005408 ABC-ATPase subunit interface; other site 511437005409 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511437005410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005411 dimer interface [polypeptide binding]; other site 511437005412 conserved gate region; other site 511437005413 putative PBP binding loops; other site 511437005414 ABC-ATPase subunit interface; other site 511437005415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511437005416 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511437005417 substrate binding pocket [chemical binding]; other site 511437005418 membrane-bound complex binding site; other site 511437005419 hinge residues; other site 511437005420 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511437005421 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 511437005422 Walker A/P-loop; other site 511437005423 ATP binding site [chemical binding]; other site 511437005424 Q-loop/lid; other site 511437005425 ABC transporter signature motif; other site 511437005426 Walker B; other site 511437005427 D-loop; other site 511437005428 H-loop/switch region; other site 511437005429 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 511437005430 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 511437005431 catalytic triad [active] 511437005432 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511437005433 metal binding site 2 [ion binding]; metal-binding site 511437005434 putative DNA binding helix; other site 511437005435 metal binding site 1 [ion binding]; metal-binding site 511437005436 dimer interface [polypeptide binding]; other site 511437005437 structural Zn2+ binding site [ion binding]; other site 511437005438 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511437005439 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511437005440 catalytic site [active] 511437005441 G-X2-G-X-G-K; other site 511437005442 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 511437005443 active site 511437005444 Ap4A binding cleft/pocket [chemical binding]; other site 511437005445 P4 phosphate binding site; other site 511437005446 nudix motif; other site 511437005447 putative P2/P3 phosphate binding site [ion binding]; other site 511437005448 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437005449 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 511437005450 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 511437005451 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005452 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 511437005453 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 511437005454 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 511437005455 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 511437005456 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 511437005457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005458 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437005459 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437005460 beta-D-glucuronidase; Provisional; Region: PRK10150 511437005461 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 511437005462 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 511437005463 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 511437005464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437005465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437005466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437005467 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 511437005468 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 511437005469 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 511437005470 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 511437005471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437005472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437005473 DNA binding site [nucleotide binding] 511437005474 domain linker motif; other site 511437005475 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 511437005476 dimerization interface [polypeptide binding]; other site 511437005477 ligand binding site [chemical binding]; other site 511437005478 sodium binding site [ion binding]; other site 511437005479 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511437005480 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511437005481 Ca binding site [ion binding]; other site 511437005482 active site 511437005483 catalytic site [active] 511437005484 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 511437005485 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 511437005486 active site 511437005487 homodimer interface [polypeptide binding]; other site 511437005488 catalytic site [active] 511437005489 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437005490 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437005491 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 511437005492 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005493 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 511437005494 galactonate dehydratase; Provisional; Region: PRK14017 511437005495 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 511437005496 active site pocket [active] 511437005497 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511437005498 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437005499 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437005500 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511437005501 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511437005502 peptide binding site [polypeptide binding]; other site 511437005503 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511437005504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005505 Walker A/P-loop; other site 511437005506 ATP binding site [chemical binding]; other site 511437005507 Q-loop/lid; other site 511437005508 ABC transporter signature motif; other site 511437005509 Walker B; other site 511437005510 D-loop; other site 511437005511 H-loop/switch region; other site 511437005512 ABC transporter; Region: ABC_tran_2; pfam12848 511437005513 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437005514 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 511437005515 active site 511437005516 metal binding site [ion binding]; metal-binding site 511437005517 CAAX protease self-immunity; Region: Abi; cl00558 511437005518 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 511437005519 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 511437005520 Uncharacterized conserved protein [Function unknown]; Region: COG3410 511437005521 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 511437005522 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 511437005523 active site 511437005524 galactoside permease; Reviewed; Region: lacY; PRK09528 511437005525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005526 putative substrate translocation pore; other site 511437005527 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 511437005528 active site 511437005529 Predicted transcriptional regulator [Transcription]; Region: COG4189 511437005530 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005531 putative DNA binding site [nucleotide binding]; other site 511437005532 dimerization interface [polypeptide binding]; other site 511437005533 putative Zn2+ binding site [ion binding]; other site 511437005534 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511437005535 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437005536 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 511437005537 active site 511437005538 catalytic triad [active] 511437005539 oxyanion hole [active] 511437005540 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 511437005541 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 511437005542 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 511437005543 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511437005544 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511437005545 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511437005546 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511437005547 DNA binding residues [nucleotide binding] 511437005548 putative dimer interface [polypeptide binding]; other site 511437005549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511437005550 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 511437005551 NADP binding site [chemical binding]; other site 511437005552 putative substrate binding site [chemical binding]; other site 511437005553 active site 511437005554 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 511437005555 zinc binding site [ion binding]; other site 511437005556 putative ligand binding site [chemical binding]; other site 511437005557 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 511437005558 TM-ABC transporter signature motif; other site 511437005559 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 511437005560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005561 Walker A/P-loop; other site 511437005562 ATP binding site [chemical binding]; other site 511437005563 Q-loop/lid; other site 511437005564 ABC transporter signature motif; other site 511437005565 Walker B; other site 511437005566 D-loop; other site 511437005567 H-loop/switch region; other site 511437005568 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 511437005569 hypothetical protein; Provisional; Region: PRK07205 511437005570 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511437005571 active site 511437005572 metal binding site [ion binding]; metal-binding site 511437005573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437005576 Helix-turn-helix domains; Region: HTH; cl00088 511437005577 pyruvate phosphate dikinase; Provisional; Region: PRK09279 511437005578 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511437005579 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 511437005580 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 511437005581 Helix-turn-helix domains; Region: HTH; cl00088 511437005582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511437005583 OpgC protein; Region: OpgC_C; cl00792 511437005584 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511437005585 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511437005586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005587 Coenzyme A binding pocket [chemical binding]; other site 511437005588 uracil transporter; Provisional; Region: PRK10720 511437005589 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 511437005590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437005591 Coenzyme A binding pocket [chemical binding]; other site 511437005592 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437005593 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511437005594 substrate binding site [chemical binding]; other site 511437005595 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437005596 Ligand Binding Site [chemical binding]; other site 511437005597 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 511437005598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005599 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511437005600 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511437005601 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 511437005602 active site residue [active] 511437005603 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 511437005604 amino acid transporter; Region: 2A0306; TIGR00909 511437005605 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 511437005606 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 511437005607 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437005608 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005609 Walker A/P-loop; other site 511437005610 ATP binding site [chemical binding]; other site 511437005611 Q-loop/lid; other site 511437005612 ABC transporter signature motif; other site 511437005613 Walker B; other site 511437005614 D-loop; other site 511437005615 H-loop/switch region; other site 511437005616 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437005617 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005618 Walker A/P-loop; other site 511437005619 ATP binding site [chemical binding]; other site 511437005620 Q-loop/lid; other site 511437005621 ABC transporter signature motif; other site 511437005622 Walker B; other site 511437005623 D-loop; other site 511437005624 H-loop/switch region; other site 511437005625 Cobalt transport protein; Region: CbiQ; cl00463 511437005626 NlpC/P60 family; Region: NLPC_P60; cl11438 511437005627 amino acid transporter; Region: 2A0306; TIGR00909 511437005628 Spore germination protein; Region: Spore_permease; cl15802 511437005629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005631 putative substrate translocation pore; other site 511437005632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005633 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 511437005634 Cadmium resistance transporter; Region: Cad; cl04177 511437005635 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 511437005636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511437005637 ATP binding site [chemical binding]; other site 511437005638 putative Mg++ binding site [ion binding]; other site 511437005639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511437005640 nucleotide binding region [chemical binding]; other site 511437005641 ATP-binding site [chemical binding]; other site 511437005642 RQC domain; Region: RQC; cl09632 511437005643 HRDC domain; Region: HRDC; cl02578 511437005644 Domain of unknown function (DUF389); Region: DUF389; cl00781 511437005645 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 511437005646 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 511437005647 catalytic Zn binding site [ion binding]; other site 511437005648 NAD binding site [chemical binding]; other site 511437005649 structural Zn binding site [ion binding]; other site 511437005650 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437005651 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 511437005652 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 511437005653 PYR/PP interface [polypeptide binding]; other site 511437005654 tetramer interface [polypeptide binding]; other site 511437005655 dimer interface [polypeptide binding]; other site 511437005656 TPP binding site [chemical binding]; other site 511437005657 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 511437005658 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 511437005659 TPP-binding site [chemical binding]; other site 511437005660 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511437005661 active site 511437005662 NMT1-like family; Region: NMT1_2; cl15260 511437005663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005664 dimer interface [polypeptide binding]; other site 511437005665 conserved gate region; other site 511437005666 putative PBP binding loops; other site 511437005667 ABC-ATPase subunit interface; other site 511437005668 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 511437005669 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 511437005670 Walker A/P-loop; other site 511437005671 ATP binding site [chemical binding]; other site 511437005672 Q-loop/lid; other site 511437005673 ABC transporter signature motif; other site 511437005674 Walker B; other site 511437005675 D-loop; other site 511437005676 H-loop/switch region; other site 511437005677 NIL domain; Region: NIL; cl09633 511437005678 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437005679 substrate binding site [chemical binding]; other site 511437005680 THF binding site; other site 511437005681 zinc-binding site [ion binding]; other site 511437005682 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 511437005683 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 511437005684 putative active site [active] 511437005685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437005686 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511437005687 guanine deaminase; Region: guan_deamin; TIGR02967 511437005688 active site 511437005689 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005690 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005691 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005692 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005693 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005694 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005695 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437005696 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 511437005697 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 511437005698 metal binding site [ion binding]; metal-binding site 511437005699 dimer interface [polypeptide binding]; other site 511437005700 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 511437005701 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 511437005702 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 511437005703 Fibronectin type III-like domain; Region: Fn3-like; cl15273 511437005704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005706 putative substrate translocation pore; other site 511437005707 Protein of unknown function, DUF606; Region: DUF606; cl01273 511437005708 Protein of unknown function, DUF606; Region: DUF606; cl01273 511437005709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005710 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437005711 NAD(P) binding site [chemical binding]; other site 511437005712 active site 511437005713 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 511437005714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437005715 catalytic core [active] 511437005716 L-arabinose isomerase; Provisional; Region: PRK02929 511437005717 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 511437005718 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511437005719 trimer interface [polypeptide binding]; other site 511437005720 substrate binding site [chemical binding]; other site 511437005721 Mn binding site [ion binding]; other site 511437005722 Cupin domain; Region: Cupin_2; cl09118 511437005723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511437005724 Helix-turn-helix domains; Region: HTH; cl00088 511437005725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005727 putative substrate translocation pore; other site 511437005728 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005729 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 511437005730 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 511437005731 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005732 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 511437005733 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005734 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005735 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437005736 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 511437005737 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 511437005738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 511437005740 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 511437005741 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 511437005742 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 511437005743 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 511437005744 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 511437005745 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 511437005746 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 511437005747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005748 putative substrate translocation pore; other site 511437005749 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 511437005750 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 511437005751 Predicted transcriptional regulator [Transcription]; Region: COG4189 511437005752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005753 dimerization interface [polypeptide binding]; other site 511437005754 putative DNA binding site [nucleotide binding]; other site 511437005755 putative Zn2+ binding site [ion binding]; other site 511437005756 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 511437005757 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 511437005758 active site 511437005759 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511437005760 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437005761 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 511437005762 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511437005763 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005764 Walker A/P-loop; other site 511437005765 ATP binding site [chemical binding]; other site 511437005766 Q-loop/lid; other site 511437005767 ABC transporter signature motif; other site 511437005768 Walker B; other site 511437005769 D-loop; other site 511437005770 H-loop/switch region; other site 511437005771 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 511437005772 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 511437005773 Walker A/P-loop; other site 511437005774 ATP binding site [chemical binding]; other site 511437005775 Q-loop/lid; other site 511437005776 ABC transporter signature motif; other site 511437005777 Walker B; other site 511437005778 D-loop; other site 511437005779 H-loop/switch region; other site 511437005780 Cobalt transport protein; Region: CbiQ; cl00463 511437005781 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 511437005782 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 511437005783 active site 511437005784 homotetramer interface [polypeptide binding]; other site 511437005785 homodimer interface [polypeptide binding]; other site 511437005786 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511437005787 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 511437005788 Walker A/P-loop; other site 511437005789 ATP binding site [chemical binding]; other site 511437005790 Q-loop/lid; other site 511437005791 ABC transporter signature motif; other site 511437005792 Walker B; other site 511437005793 D-loop; other site 511437005794 H-loop/switch region; other site 511437005795 TOBE domain; Region: TOBE_2; cl01440 511437005796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005797 dimer interface [polypeptide binding]; other site 511437005798 conserved gate region; other site 511437005799 putative PBP binding loops; other site 511437005800 ABC-ATPase subunit interface; other site 511437005801 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511437005802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005803 dimer interface [polypeptide binding]; other site 511437005804 conserved gate region; other site 511437005805 putative PBP binding loops; other site 511437005806 ABC-ATPase subunit interface; other site 511437005807 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511437005808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437005809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437005810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437005811 putative substrate translocation pore; other site 511437005812 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 511437005813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437005814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437005815 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511437005816 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437005817 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511437005818 putative phosphoketolase; Provisional; Region: PRK05261 511437005819 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 511437005820 TPP-binding site; other site 511437005821 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 511437005822 XFP C-terminal domain; Region: XFP_C; pfam09363 511437005823 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511437005824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511437005825 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 511437005826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005827 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511437005828 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511437005829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437005830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437005831 homodimer interface [polypeptide binding]; other site 511437005832 catalytic residue [active] 511437005833 dihydrodipicolinate reductase; Provisional; Region: PRK00048 511437005834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005835 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 511437005836 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 511437005837 dihydrodipicolinate synthase; Region: dapA; TIGR00674 511437005838 dimer interface [polypeptide binding]; other site 511437005839 active site 511437005840 catalytic residue [active] 511437005841 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511437005842 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 511437005843 metal binding site [ion binding]; metal-binding site 511437005844 putative dimer interface [polypeptide binding]; other site 511437005845 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 511437005846 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 511437005847 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511437005848 putative trimer interface [polypeptide binding]; other site 511437005849 putative CoA binding site [chemical binding]; other site 511437005850 diaminopimelate decarboxylase; Region: lysA; TIGR01048 511437005851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511437005852 active site 511437005853 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511437005854 substrate binding site [chemical binding]; other site 511437005855 catalytic residues [active] 511437005856 dimer interface [polypeptide binding]; other site 511437005857 aspartate kinase; Reviewed; Region: PRK09034 511437005858 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 511437005859 putative catalytic residues [active] 511437005860 putative nucleotide binding site [chemical binding]; other site 511437005861 putative aspartate binding site [chemical binding]; other site 511437005862 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 511437005863 allosteric regulatory residue; other site 511437005864 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 511437005865 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511437005866 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 511437005867 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 511437005868 6-phosphofructokinase 2; Provisional; Region: PRK10294 511437005869 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511437005870 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 511437005871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005872 DEAD_2; Region: DEAD_2; pfam06733 511437005873 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005874 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 511437005875 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 511437005876 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511437005877 metal binding site 2 [ion binding]; metal-binding site 511437005878 putative DNA binding helix; other site 511437005879 metal binding site 1 [ion binding]; metal-binding site 511437005880 dimer interface [polypeptide binding]; other site 511437005881 structural Zn2+ binding site [ion binding]; other site 511437005882 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511437005883 amidase catalytic site [active] 511437005884 Zn binding residues [ion binding]; other site 511437005885 substrate binding site [chemical binding]; other site 511437005886 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 511437005887 nucleotide binding site [chemical binding]; other site 511437005888 homotetrameric interface [polypeptide binding]; other site 511437005889 putative phosphate binding site [ion binding]; other site 511437005890 putative allosteric binding site; other site 511437005891 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 511437005892 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 511437005893 putative catalytic cysteine [active] 511437005894 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511437005895 Helix-turn-helix domains; Region: HTH; cl00088 511437005896 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 511437005897 active site residue [active] 511437005898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437005899 dimer interface [polypeptide binding]; other site 511437005900 conserved gate region; other site 511437005901 ABC-ATPase subunit interface; other site 511437005902 NMT1-like family; Region: NMT1_2; cl15260 511437005903 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511437005904 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 511437005905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005906 Walker A/P-loop; other site 511437005907 ATP binding site [chemical binding]; other site 511437005908 Q-loop/lid; other site 511437005909 ABC transporter signature motif; other site 511437005910 Walker B; other site 511437005911 D-loop; other site 511437005912 H-loop/switch region; other site 511437005913 YibE/F-like protein; Region: YibE_F; cl02259 511437005914 YibE/F-like protein; Region: YibE_F; cl02259 511437005915 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437005916 Ligand Binding Site [chemical binding]; other site 511437005917 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 511437005918 active site 2 [active] 511437005919 active site 1 [active] 511437005920 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437005921 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 511437005922 putative NAD(P) binding site [chemical binding]; other site 511437005923 catalytic Zn binding site [ion binding]; other site 511437005924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437005925 dimerization interface [polypeptide binding]; other site 511437005926 putative DNA binding site [nucleotide binding]; other site 511437005927 putative Zn2+ binding site [ion binding]; other site 511437005928 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437005929 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 511437005930 AzlC protein; Region: AzlC; cl00570 511437005931 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 511437005932 putative ADP-ribose binding site [chemical binding]; other site 511437005933 putative active site [active] 511437005934 recombination factor protein RarA; Reviewed; Region: PRK13342 511437005935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437005936 Walker A motif; other site 511437005937 ATP binding site [chemical binding]; other site 511437005938 Walker B motif; other site 511437005939 arginine finger; other site 511437005940 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511437005941 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 511437005942 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 511437005943 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 511437005944 active site 511437005945 Zn binding site [ion binding]; other site 511437005946 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 511437005947 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 511437005948 catalytic site [active] 511437005949 metal binding site [ion binding]; metal-binding site 511437005950 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511437005951 active site 511437005952 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 511437005953 tetramer interfaces [polypeptide binding]; other site 511437005954 binuclear metal-binding site [ion binding]; other site 511437005955 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 511437005956 active site 511437005957 DNA binding site [nucleotide binding] 511437005958 Protein of unknown function, DUF488; Region: DUF488; cl01246 511437005959 beta-phosphoglucomutase; Region: bPGM; TIGR01990 511437005960 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437005961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511437005962 motif II; other site 511437005963 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 511437005964 dimer interface [polypeptide binding]; other site 511437005965 hypothetical protein; Provisional; Region: PRK04164 511437005966 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 511437005967 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 511437005968 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 511437005969 RNA/DNA hybrid binding site [nucleotide binding]; other site 511437005970 active site 511437005971 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437005972 putative acyl-acceptor binding pocket; other site 511437005973 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 511437005974 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 511437005975 Ligand binding site; other site 511437005976 metal-binding site 511437005977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511437005978 putative acyl-acceptor binding pocket; other site 511437005979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437005980 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437005981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437005982 Walker A/P-loop; other site 511437005983 ATP binding site [chemical binding]; other site 511437005984 Q-loop/lid; other site 511437005985 ABC transporter signature motif; other site 511437005986 Walker B; other site 511437005987 D-loop; other site 511437005988 H-loop/switch region; other site 511437005989 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 511437005990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437005991 active site 511437005992 cytosine deaminase; Provisional; Region: PRK09230 511437005993 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511437005994 active site 511437005995 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511437005996 Cation transport protein; Region: TrkH; cl10514 511437005997 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511437005998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437005999 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 511437006000 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511437006001 dimer interface [polypeptide binding]; other site 511437006002 substrate binding site [chemical binding]; other site 511437006003 ATP binding site [chemical binding]; other site 511437006004 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 511437006005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006006 active site 511437006007 catalytic tetrad [active] 511437006008 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 511437006009 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437006010 OsmC-like protein; Region: OsmC; cl00767 511437006011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437006012 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511437006013 Walker A motif; other site 511437006014 ATP binding site [chemical binding]; other site 511437006015 Walker B motif; other site 511437006016 arginine finger; other site 511437006017 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 511437006018 UvrB/uvrC motif; Region: UVR; pfam02151 511437006019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511437006020 Walker A motif; other site 511437006021 ATP binding site [chemical binding]; other site 511437006022 Walker B motif; other site 511437006023 arginine finger; other site 511437006024 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 511437006025 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 511437006026 DNA-binding site [nucleotide binding]; DNA binding site 511437006027 RNA-binding motif; other site 511437006028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511437006029 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 511437006030 dimer interface [polypeptide binding]; other site 511437006031 FMN binding site [chemical binding]; other site 511437006032 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 511437006033 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437006034 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 511437006035 HPr interaction site; other site 511437006036 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511437006037 active site 511437006038 phosphorylation site [posttranslational modification] 511437006039 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437006040 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437006041 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 511437006042 Walker A/P-loop; other site 511437006043 ATP binding site [chemical binding]; other site 511437006044 Q-loop/lid; other site 511437006045 ABC transporter signature motif; other site 511437006046 Walker B; other site 511437006047 D-loop; other site 511437006048 H-loop/switch region; other site 511437006049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511437006050 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 511437006051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437006052 Walker A/P-loop; other site 511437006053 ATP binding site [chemical binding]; other site 511437006054 Q-loop/lid; other site 511437006055 ABC transporter signature motif; other site 511437006056 Walker B; other site 511437006057 D-loop; other site 511437006058 H-loop/switch region; other site 511437006059 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 511437006060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006061 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437006062 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 511437006063 T surface-antigen of pili; Region: FctA; pfam12892 511437006064 Gram positive anchor; Region: Gram_pos_anchor; cl15427 511437006065 PemK-like protein; Region: PemK; cl00995 511437006066 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 511437006067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511437006069 NAD(P) binding site [chemical binding]; other site 511437006070 active site 511437006071 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 511437006072 Helix-turn-helix domains; Region: HTH; cl00088 511437006073 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 511437006074 dimerization interface [polypeptide binding]; other site 511437006075 substrate binding pocket [chemical binding]; other site 511437006076 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 511437006077 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 511437006078 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 511437006079 active site 511437006080 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511437006081 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437006082 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511437006083 lipoyl attachment site [posttranslational modification]; other site 511437006084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006086 DNA binding site [nucleotide binding] 511437006087 domain linker motif; other site 511437006088 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 511437006089 putative dimerization interface [polypeptide binding]; other site 511437006090 putative ligand binding site [chemical binding]; other site 511437006091 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 511437006092 Citrate transporter; Region: CitMHS; pfam03600 511437006093 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 511437006094 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 511437006095 NADP binding site [chemical binding]; other site 511437006096 homodimer interface [polypeptide binding]; other site 511437006097 active site 511437006098 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437006099 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 511437006100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006101 DNA binding site [nucleotide binding] 511437006102 domain linker motif; other site 511437006103 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511437006104 putative dimerization interface [polypeptide binding]; other site 511437006105 putative ligand binding site [chemical binding]; other site 511437006106 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 511437006107 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 511437006108 active site 511437006109 substrate binding site [chemical binding]; other site 511437006110 metal binding site [ion binding]; metal-binding site 511437006111 CAAX protease self-immunity; Region: Abi; cl00558 511437006112 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 511437006113 active site 511437006114 DNA binding site [nucleotide binding] 511437006115 putative phosphate binding site [ion binding]; other site 511437006116 putative catalytic site [active] 511437006117 metal binding site A [ion binding]; metal-binding site 511437006118 AP binding site [nucleotide binding]; other site 511437006119 metal binding site B [ion binding]; metal-binding site 511437006120 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 511437006121 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 511437006122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006123 putative substrate translocation pore; other site 511437006124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006125 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 511437006126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006127 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 511437006128 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437006129 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437006130 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 511437006131 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 511437006132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437006133 Walker A/P-loop; other site 511437006134 ATP binding site [chemical binding]; other site 511437006135 Q-loop/lid; other site 511437006136 ABC transporter signature motif; other site 511437006137 Walker B; other site 511437006138 D-loop; other site 511437006139 H-loop/switch region; other site 511437006140 ABC transporter; Region: ABC_tran_2; pfam12848 511437006141 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 511437006142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437006143 catalytic core [active] 511437006144 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 511437006145 ZIP Zinc transporter; Region: Zip; pfam02535 511437006146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006147 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006148 active site 511437006149 catalytic tetrad [active] 511437006150 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437006151 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006152 active site 511437006153 substrate binding site [chemical binding]; other site 511437006154 trimer interface [polypeptide binding]; other site 511437006155 CoA binding site [chemical binding]; other site 511437006156 L-arabinose isomerase; Provisional; Region: PRK02929 511437006157 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 511437006158 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511437006159 substrate binding site [chemical binding]; other site 511437006160 trimer interface [polypeptide binding]; other site 511437006161 Mn binding site [ion binding]; other site 511437006162 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511437006163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006164 putative substrate translocation pore; other site 511437006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006167 DNA-binding site [nucleotide binding]; DNA binding site 511437006168 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006169 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 511437006170 putative dimerization interface [polypeptide binding]; other site 511437006171 putative ligand binding site [chemical binding]; other site 511437006172 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 511437006173 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 511437006174 active site 511437006175 catalytic residues [active] 511437006176 Acetokinase family; Region: Acetate_kinase; cl01029 511437006177 propionate/acetate kinase; Provisional; Region: PRK12379 511437006178 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 511437006179 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 511437006180 N- and C-terminal domain interface [polypeptide binding]; other site 511437006181 putative active site [active] 511437006182 catalytic site [active] 511437006183 metal binding site [ion binding]; metal-binding site 511437006184 carbohydrate binding site [chemical binding]; other site 511437006185 ATP binding site [chemical binding]; other site 511437006186 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 511437006187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006188 Glucuronate isomerase; Region: UxaC; cl00829 511437006189 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 511437006190 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511437006191 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511437006192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511437006193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006194 DNA-binding site [nucleotide binding]; DNA binding site 511437006195 FCD domain; Region: FCD; cl11656 511437006196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006198 putative substrate translocation pore; other site 511437006199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006200 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 511437006201 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 511437006202 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 511437006203 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 511437006204 Cupin domain; Region: Cupin_2; cl09118 511437006205 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 511437006206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006207 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 511437006208 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437006209 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 511437006210 active site 511437006211 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511437006212 NlpC/P60 family; Region: NLPC_P60; cl11438 511437006213 OsmC-like protein; Region: OsmC; cl00767 511437006214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 511437006216 amino acid transporter; Region: 2A0306; TIGR00909 511437006217 Spore germination protein; Region: Spore_permease; cl15802 511437006218 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 511437006219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 511437006220 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006221 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006222 putative NAD(P) binding site [chemical binding]; other site 511437006223 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511437006224 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511437006225 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511437006226 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511437006227 Ligand Binding Site [chemical binding]; other site 511437006228 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511437006229 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 511437006230 active site 511437006231 amidase; Provisional; Region: PRK06529 511437006232 Amidase; Region: Amidase; cl11426 511437006233 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 511437006234 putative active site [active] 511437006235 catalytic triad [active] 511437006236 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511437006237 putative phosphoketolase; Provisional; Region: PRK05261 511437006238 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 511437006239 TPP-binding site; other site 511437006240 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 511437006241 XFP C-terminal domain; Region: XFP_C; pfam09363 511437006242 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 511437006243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006244 putative substrate translocation pore; other site 511437006245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006246 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511437006247 DNA-binding site [nucleotide binding]; DNA binding site 511437006248 UTRA domain; Region: UTRA; cl01230 511437006249 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 511437006250 putative deacylase active site [active] 511437006251 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 511437006252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511437006253 Zn2+ binding site [ion binding]; other site 511437006254 Mg2+ binding site [ion binding]; other site 511437006255 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 511437006256 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 511437006257 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 511437006258 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 511437006259 putative catalytic cysteine [active] 511437006260 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 511437006261 putative active site [active] 511437006262 metal binding site [ion binding]; metal-binding site 511437006263 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511437006264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437006265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437006266 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437006267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006268 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511437006269 active site 511437006270 catalytic tetrad [active] 511437006271 maltose O-acetyltransferase; Provisional; Region: PRK10092 511437006272 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006273 active site 511437006274 substrate binding site [chemical binding]; other site 511437006275 trimer interface [polypeptide binding]; other site 511437006276 CoA binding site [chemical binding]; other site 511437006277 Membrane transport protein; Region: Mem_trans; cl09117 511437006278 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511437006279 Domain of unknown function DUF21; Region: DUF21; pfam01595 511437006280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511437006281 Transporter associated domain; Region: CorC_HlyC; cl08393 511437006282 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437006283 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511437006284 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511437006285 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437006286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006288 putative substrate translocation pore; other site 511437006289 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 511437006290 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 511437006291 active site 511437006292 substrate binding site [chemical binding]; other site 511437006293 trimer interface [polypeptide binding]; other site 511437006294 CoA binding site [chemical binding]; other site 511437006295 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 511437006296 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 511437006297 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 511437006298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006299 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 511437006300 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 511437006301 PemK-like protein; Region: PemK; cl00995 511437006302 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 511437006303 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 511437006304 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511437006305 Gram positive anchor; Region: Gram_pos_anchor; cl15427 511437006306 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 511437006307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 511437006309 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 511437006310 Abi-like protein; Region: Abi_2; cl01988 511437006311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437006312 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437006313 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 511437006314 thiamine phosphate binding site [chemical binding]; other site 511437006315 active site 511437006316 pyrophosphate binding site [ion binding]; other site 511437006317 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 511437006318 thiS-thiF/thiG interaction site; other site 511437006319 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 511437006320 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 511437006321 putative ATP binding site [chemical binding]; other site 511437006322 putative substrate interface [chemical binding]; other site 511437006323 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 511437006324 phosphate binding site [ion binding]; other site 511437006325 allantoate amidohydrolase; Reviewed; Region: PRK09290 511437006326 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 511437006327 active site 511437006328 metal binding site [ion binding]; metal-binding site 511437006329 dimer interface [polypeptide binding]; other site 511437006330 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 511437006331 multicopper oxidase; Provisional; Region: PRK10965 511437006332 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 511437006333 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 511437006334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511437006335 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511437006336 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 511437006337 putative acyltransferase; Provisional; Region: PRK05790 511437006338 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 511437006339 dimer interface [polypeptide binding]; other site 511437006340 active site 511437006341 CsbD-like; Region: CsbD; cl15799 511437006342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 511437006343 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 511437006344 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 511437006345 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511437006346 homodimer interface [polypeptide binding]; other site 511437006347 substrate-cofactor binding pocket; other site 511437006348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006349 catalytic residue [active] 511437006350 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 511437006351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437006352 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511437006353 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 511437006354 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 511437006355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006356 NAD(P) binding site [chemical binding]; other site 511437006357 active site 511437006358 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 511437006359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511437006360 active site 511437006361 catalytic tetrad [active] 511437006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006363 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 511437006364 NAD(P) binding site [chemical binding]; other site 511437006365 active site 511437006366 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511437006367 QueT transporter; Region: QueT; cl01932 511437006368 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 511437006369 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 511437006370 dimer interface [polypeptide binding]; other site 511437006371 active site 511437006372 metal binding site [ion binding]; metal-binding site 511437006373 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006374 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006375 putative NAD(P) binding site [chemical binding]; other site 511437006376 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511437006377 synthetase active site [active] 511437006378 NTP binding site [chemical binding]; other site 511437006379 metal binding site [ion binding]; metal-binding site 511437006380 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 511437006381 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 511437006382 putative active site [active] 511437006383 catalytic site [active] 511437006384 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 511437006385 putative active site [active] 511437006386 catalytic site [active] 511437006387 hypothetical protein; Provisional; Region: PRK11171 511437006388 Cupin domain; Region: Cupin_2; cl09118 511437006389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511437006390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511437006391 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 511437006392 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 511437006393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006394 putative substrate translocation pore; other site 511437006395 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 511437006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006398 putative substrate translocation pore; other site 511437006399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511437006400 S-adenosylmethionine binding site [chemical binding]; other site 511437006401 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511437006402 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 511437006403 putative active site [active] 511437006404 catalytic triad [active] 511437006405 putative dimer interface [polypeptide binding]; other site 511437006406 PQ loop repeat; Region: PQ-loop; cl12056 511437006407 Protein of unknown function (DUF419); Region: DUF419; cl15265 511437006408 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 511437006409 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511437006410 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511437006411 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 511437006412 active site 511437006413 ribulose/triose binding site [chemical binding]; other site 511437006414 phosphate binding site [ion binding]; other site 511437006415 substrate (anthranilate) binding pocket [chemical binding]; other site 511437006416 product (indole) binding pocket [chemical binding]; other site 511437006417 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 511437006418 active site 511437006419 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 511437006420 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 511437006421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006422 catalytic residue [active] 511437006423 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 511437006424 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 511437006425 substrate binding site [chemical binding]; other site 511437006426 active site 511437006427 catalytic residues [active] 511437006428 heterodimer interface [polypeptide binding]; other site 511437006429 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 511437006430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006431 non-specific DNA binding site [nucleotide binding]; other site 511437006432 salt bridge; other site 511437006433 sequence-specific DNA binding site [nucleotide binding]; other site 511437006434 stage V sporulation protein B; Region: spore_V_B; TIGR02900 511437006435 MatE; Region: MatE; cl10513 511437006436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006437 non-specific DNA binding site [nucleotide binding]; other site 511437006438 salt bridge; other site 511437006439 sequence-specific DNA binding site [nucleotide binding]; other site 511437006440 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 511437006441 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 511437006442 N-terminal domain interface [polypeptide binding]; other site 511437006443 dimer interface [polypeptide binding]; other site 511437006444 substrate binding pocket (H-site) [chemical binding]; other site 511437006445 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 511437006446 peptidase domain interface [polypeptide binding]; other site 511437006447 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 511437006448 active site 511437006449 catalytic triad [active] 511437006450 calcium binding site [ion binding]; other site 511437006451 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 511437006452 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511437006453 peptide binding site [polypeptide binding]; other site 511437006454 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 511437006455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006456 dimer interface [polypeptide binding]; other site 511437006457 conserved gate region; other site 511437006458 putative PBP binding loops; other site 511437006459 ABC-ATPase subunit interface; other site 511437006460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511437006461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006462 dimer interface [polypeptide binding]; other site 511437006463 conserved gate region; other site 511437006464 putative PBP binding loops; other site 511437006465 ABC-ATPase subunit interface; other site 511437006466 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511437006467 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511437006468 Walker A/P-loop; other site 511437006469 ATP binding site [chemical binding]; other site 511437006470 Q-loop/lid; other site 511437006471 ABC transporter signature motif; other site 511437006472 Walker B; other site 511437006473 D-loop; other site 511437006474 H-loop/switch region; other site 511437006475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437006476 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511437006477 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 511437006478 Walker A/P-loop; other site 511437006479 ATP binding site [chemical binding]; other site 511437006480 Q-loop/lid; other site 511437006481 ABC transporter signature motif; other site 511437006482 Walker B; other site 511437006483 D-loop; other site 511437006484 H-loop/switch region; other site 511437006485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511437006486 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006487 Helix-turn-helix domains; Region: HTH; cl00088 511437006488 Integrase core domain; Region: rve; cl01316 511437006489 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 511437006490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511437006491 active site 511437006492 Collagen binding domain; Region: Collagen_bind; pfam05737 511437006493 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 511437006494 putative Ca2+ binding sites [ion binding]; other site 511437006495 domain interaction interfaces; other site 511437006496 putative ligand binding motif; other site 511437006497 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 511437006498 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 511437006499 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511437006500 NAD binding site [chemical binding]; other site 511437006501 substrate binding site [chemical binding]; other site 511437006502 putative active site [active] 511437006503 maltose phosphorylase; Provisional; Region: PRK13807 511437006504 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 511437006505 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 511437006506 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 511437006507 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 511437006508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006509 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511437006510 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 511437006511 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511437006512 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 511437006513 putative NAD(P) binding site [chemical binding]; other site 511437006514 catalytic Zn binding site [ion binding]; other site 511437006515 Predicted membrane protein [Function unknown]; Region: COG2364 511437006516 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511437006517 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 511437006518 active site 511437006519 metal binding site [ion binding]; metal-binding site 511437006520 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 511437006521 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511437006522 active site 511437006523 dimer interface [polypeptide binding]; other site 511437006524 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511437006525 dimer interface [polypeptide binding]; other site 511437006526 active site 511437006527 H+ Antiporter protein; Region: 2A0121; TIGR00900 511437006528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437006529 Helix-turn-helix domains; Region: HTH; cl00088 511437006530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437006531 Helix-turn-helix domains; Region: HTH; cl00088 511437006532 putative transposase OrfB; Reviewed; Region: PHA02517 511437006533 HTH-like domain; Region: HTH_21; pfam13276 511437006534 Integrase core domain; Region: rve; cl01316 511437006535 Integrase core domain; Region: rve_3; cl15866 511437006536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511437006537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511437006538 DNA binding site [nucleotide binding] 511437006539 domain linker motif; other site 511437006540 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511437006541 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 511437006542 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511437006543 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 511437006544 putative active site [active] 511437006545 catalytic site [active] 511437006546 putative metal binding site [ion binding]; other site 511437006547 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 511437006548 trimer interface [polypeptide binding]; other site 511437006549 active site 511437006550 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 511437006551 Protein of unknown function (DUF436); Region: DUF436; cl01860 511437006552 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 511437006553 substrate binding site [chemical binding]; other site 511437006554 ATP binding site [chemical binding]; other site 511437006555 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 511437006556 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511437006557 substrate binding site [chemical binding]; other site 511437006558 THF binding site; other site 511437006559 zinc-binding site [ion binding]; other site 511437006560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006562 putative substrate translocation pore; other site 511437006563 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511437006564 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 511437006565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437006566 Walker A/P-loop; other site 511437006567 ATP binding site [chemical binding]; other site 511437006568 Q-loop/lid; other site 511437006569 ABC transporter signature motif; other site 511437006570 Walker B; other site 511437006571 D-loop; other site 511437006572 H-loop/switch region; other site 511437006573 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 511437006574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511437006575 active site 511437006576 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 511437006577 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 511437006578 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 511437006579 D-lactate dehydrogenase; Validated; Region: PRK08605 511437006580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006581 malate dehydrogenase; Provisional; Region: PRK13529 511437006582 Malic enzyme, N-terminal domain; Region: malic; pfam00390 511437006583 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 511437006584 NAD(P) binding site [chemical binding]; other site 511437006585 fumarate hydratase; Reviewed; Region: fumC; PRK00485 511437006586 Class II fumarases; Region: Fumarase_classII; cd01362 511437006587 active site 511437006588 tetramer interface [polypeptide binding]; other site 511437006589 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511437006590 active site residue [active] 511437006591 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511437006592 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 511437006593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006594 non-specific DNA binding site [nucleotide binding]; other site 511437006595 salt bridge; other site 511437006596 sequence-specific DNA binding site [nucleotide binding]; other site 511437006597 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 511437006598 CAAX protease self-immunity; Region: Abi; cl00558 511437006599 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511437006600 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 511437006601 Walker A/P-loop; other site 511437006602 ATP binding site [chemical binding]; other site 511437006603 Q-loop/lid; other site 511437006604 ABC transporter signature motif; other site 511437006605 Walker B; other site 511437006606 D-loop; other site 511437006607 H-loop/switch region; other site 511437006608 Predicted transcriptional regulators [Transcription]; Region: COG1725 511437006609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511437006610 DNA-binding site [nucleotide binding]; DNA binding site 511437006611 Helix-turn-helix domains; Region: HTH; cl00088 511437006612 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006613 Integrase core domain; Region: rve; cl01316 511437006614 Integrase core domain; Region: rve_3; cl15866 511437006615 Transposase domain (DUF772); Region: DUF772; cl15789 511437006616 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511437006617 Transposase domain (DUF772); Region: DUF772; cl15789 511437006618 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006619 Helix-turn-helix domains; Region: HTH; cl00088 511437006620 Integrase core domain; Region: rve; cl01316 511437006621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006622 non-specific DNA binding site [nucleotide binding]; other site 511437006623 salt bridge; other site 511437006624 sequence-specific DNA binding site [nucleotide binding]; other site 511437006625 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 511437006626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511437006627 non-specific DNA binding site [nucleotide binding]; other site 511437006628 salt bridge; other site 511437006629 sequence-specific DNA binding site [nucleotide binding]; other site 511437006630 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 511437006631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006632 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 511437006633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 511437006634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006636 putative substrate translocation pore; other site 511437006637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006638 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 511437006639 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 511437006640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511437006641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006642 homodimer interface [polypeptide binding]; other site 511437006643 catalytic residue [active] 511437006644 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 511437006645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006646 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511437006647 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 511437006648 gating phenylalanine in ion channel; other site 511437006649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511437006650 Helix-turn-helix domains; Region: HTH; cl00088 511437006651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437006652 dimerization interface [polypeptide binding]; other site 511437006653 aspartate kinase; Reviewed; Region: PRK09034 511437006654 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 511437006655 nucleotide binding site [chemical binding]; other site 511437006656 substrate binding site [chemical binding]; other site 511437006657 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437006658 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511437006659 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 511437006660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006661 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511437006662 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 511437006663 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 511437006664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006665 catalytic residue [active] 511437006666 homoserine kinase; Provisional; Region: PRK01212 511437006667 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511437006668 hypothetical protein; Provisional; Region: PRK04435 511437006669 Helix-turn-helix domains; Region: HTH; cl00088 511437006670 DNA-binding interface [nucleotide binding]; DNA binding site 511437006671 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 511437006672 Uncharacterized conserved protein [Function unknown]; Region: COG2966 511437006673 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437006674 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 511437006675 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006677 putative NAD(P) binding site [chemical binding]; other site 511437006678 Bacitracin resistance protein BacA; Region: BacA; cl00858 511437006679 Putative esterase; Region: Esterase; pfam00756 511437006680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437006681 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 511437006682 CHAD domain; Region: CHAD; cl10506 511437006683 Helix-turn-helix domains; Region: HTH; cl00088 511437006684 hypothetical protein; Provisional; Region: PRK11281 511437006685 amino acid transporter; Region: 2A0306; TIGR00909 511437006686 Spore germination protein; Region: Spore_permease; cl15802 511437006687 Spore germination protein; Region: Spore_permease; cl15802 511437006688 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 511437006689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511437006690 inhibitor-cofactor binding pocket; inhibition site 511437006691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511437006692 catalytic residue [active] 511437006693 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 511437006694 putative catalytic site [active] 511437006695 putative metal binding site [ion binding]; other site 511437006696 putative phosphate binding site [ion binding]; other site 511437006697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437006698 catalytic core [active] 511437006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511437006701 putative substrate translocation pore; other site 511437006702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511437006703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511437006704 Coenzyme A binding pocket [chemical binding]; other site 511437006705 TIR domain; Region: TIR_2; cl15770 511437006706 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 511437006707 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 511437006708 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 511437006709 Helix-turn-helix domains; Region: HTH; cl00088 511437006710 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006711 Integrase core domain; Region: rve; cl01316 511437006712 Integrase core domain; Region: rve_3; cl15866 511437006713 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 511437006714 active site 511437006715 pyruvate oxidase; Provisional; Region: PRK08611 511437006716 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 511437006717 PYR/PP interface [polypeptide binding]; other site 511437006718 tetramer interface [polypeptide binding]; other site 511437006719 dimer interface [polypeptide binding]; other site 511437006720 TPP binding site [chemical binding]; other site 511437006721 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 511437006722 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 511437006723 TPP-binding site [chemical binding]; other site 511437006724 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 511437006725 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 511437006726 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 511437006727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006728 putative substrate translocation pore; other site 511437006729 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006730 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006731 putative NAD(P) binding site [chemical binding]; other site 511437006732 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511437006733 PhoU domain; Region: PhoU; pfam01895 511437006734 PhoU domain; Region: PhoU; pfam01895 511437006735 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 511437006736 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 511437006737 Walker A/P-loop; other site 511437006738 ATP binding site [chemical binding]; other site 511437006739 Q-loop/lid; other site 511437006740 ABC transporter signature motif; other site 511437006741 Walker B; other site 511437006742 D-loop; other site 511437006743 H-loop/switch region; other site 511437006744 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 511437006745 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 511437006746 Walker A/P-loop; other site 511437006747 ATP binding site [chemical binding]; other site 511437006748 Q-loop/lid; other site 511437006749 ABC transporter signature motif; other site 511437006750 Walker B; other site 511437006751 D-loop; other site 511437006752 H-loop/switch region; other site 511437006753 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511437006754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006755 dimer interface [polypeptide binding]; other site 511437006756 conserved gate region; other site 511437006757 putative PBP binding loops; other site 511437006758 ABC-ATPase subunit interface; other site 511437006759 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 511437006760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511437006761 dimer interface [polypeptide binding]; other site 511437006762 conserved gate region; other site 511437006763 putative PBP binding loops; other site 511437006764 ABC-ATPase subunit interface; other site 511437006765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 511437006766 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511437006767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511437006768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511437006769 DNA binding site [nucleotide binding] 511437006770 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 511437006771 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 511437006772 active site 511437006773 dimer interface [polypeptide binding]; other site 511437006774 metal binding site [ion binding]; metal-binding site 511437006775 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 511437006776 NeuB family; Region: NeuB; cl00496 511437006777 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 511437006778 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511437006779 chorismate binding enzyme; Region: Chorismate_bind; cl10555 511437006780 Glutamine amidotransferase class-I; Region: GATase; pfam00117 511437006781 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511437006782 glutamine binding [chemical binding]; other site 511437006783 catalytic triad [active] 511437006784 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 511437006785 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 511437006786 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 511437006787 metal binding site [ion binding]; metal-binding site 511437006788 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 511437006789 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 511437006790 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511437006791 catalytic core [active] 511437006792 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 511437006793 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511437006794 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 511437006795 Catalytic site [active] 511437006796 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511437006797 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 511437006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511437006799 putative substrate translocation pore; other site 511437006800 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511437006801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006802 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511437006803 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511437006804 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511437006805 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511437006806 G1 box; other site 511437006807 GTP/Mg2+ binding site [chemical binding]; other site 511437006808 Switch I region; other site 511437006809 G2 box; other site 511437006810 Switch II region; other site 511437006811 G3 box; other site 511437006812 G4 box; other site 511437006813 G5 box; other site 511437006814 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511437006815 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 511437006816 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 511437006817 G-X-X-G motif; other site 511437006818 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 511437006819 RxxxH motif; other site 511437006820 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511437006821 Cation efflux family; Region: Cation_efflux; cl00316 511437006822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511437006823 acetoin reductases; Region: 23BDH; TIGR02415 511437006824 NAD(P) binding site [chemical binding]; other site 511437006825 active site 511437006826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437006827 Helix-turn-helix domains; Region: HTH; cl00088 511437006828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511437006829 Helix-turn-helix domains; Region: HTH; cl00088 511437006830 putative transposase OrfB; Reviewed; Region: PHA02517 511437006831 HTH-like domain; Region: HTH_21; pfam13276 511437006832 Integrase core domain; Region: rve; cl01316 511437006833 Integrase core domain; Region: rve_3; cl15866 511437006834 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511437006835 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511437006836 putative NAD(P) binding site [chemical binding]; other site 511437006837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437006838 dimerization interface [polypeptide binding]; other site 511437006839 putative DNA binding site [nucleotide binding]; other site 511437006840 putative Zn2+ binding site [ion binding]; other site 511437006841 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 511437006842 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 511437006843 potential catalytic triad [active] 511437006844 conserved cys residue [active] 511437006845 Glycerate kinase family; Region: Gly_kinase; cl00841 511437006846 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 511437006847 Ribonuclease P; Region: Ribonuclease_P; cl00457 511437006848 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 511437006849 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511437006850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437006851 P-loop; other site 511437006852 Magnesium ion binding site [ion binding]; other site 511437006853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511437006854 Magnesium ion binding site [ion binding]; other site 511437006855 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 511437006856 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511437006857 catalytic residues [active] 511437006858 catalytic nucleophile [active] 511437006859 Presynaptic Site I dimer interface [polypeptide binding]; other site 511437006860 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511437006861 Synaptic Flat tetramer interface [polypeptide binding]; other site 511437006862 Synaptic Site I dimer interface [polypeptide binding]; other site 511437006863 DNA binding site [nucleotide binding] 511437006864 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 511437006865 DNA-binding interface [nucleotide binding]; DNA binding site 511437006866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511437006867 dimerization interface [polypeptide binding]; other site 511437006868 putative DNA binding site [nucleotide binding]; other site 511437006869 putative Zn2+ binding site [ion binding]; other site 511437006870 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511437006871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437006872 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437006873 DDE domain; Region: DDE_Tnp_IS240; pfam13610 511437006874 Integrase core domain; Region: rve; cl01316 511437006875 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 511437006876 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511437006877 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 511437006878 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 511437006879 Helix-turn-helix domains; Region: HTH; cl00088 511437006880 Integrase core domain; Region: rve; cl01316 511437006881 putative transposase OrfB; Reviewed; Region: PHA02517 511437006882 HTH-like domain; Region: HTH_21; pfam13276 511437006883 Integrase core domain; Region: rve; cl01316 511437006884 Integrase core domain; Region: rve_3; cl15866 511437006885 Helix-turn-helix domains; Region: HTH; cl00088 511437006886 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511437006887 active site 511437006888 putative interdomain interaction site [polypeptide binding]; other site 511437006889 putative metal-binding site [ion binding]; other site 511437006890 putative nucleotide binding site [chemical binding]; other site 511437006891 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 511437006892 MobA/MobL family; Region: MobA_MobL; pfam03389 511437006893 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 511437006894 Zeta toxin; Region: Zeta_toxin; pfam06414 511437006895 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 511437006896 RelB antitoxin; Region: RelB; cl01171 511437006897 Helix-turn-helix domains; Region: HTH; cl00088