-- dump date 20120504_151005 -- class Genbank::misc_feature -- table misc_feature_note -- id note 543734000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 543734000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734000003 Walker A motif; other site 543734000004 ATP binding site [chemical binding]; other site 543734000005 Walker B motif; other site 543734000006 arginine finger; other site 543734000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 543734000008 DnaA box-binding interface [nucleotide binding]; other site 543734000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 543734000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 543734000011 putative DNA binding surface [nucleotide binding]; other site 543734000012 dimer interface [polypeptide binding]; other site 543734000013 beta-clamp/clamp loader binding surface; other site 543734000014 beta-clamp/translesion DNA polymerase binding surface; other site 543734000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 543734000016 recombination protein F; Reviewed; Region: recF; PRK00064 543734000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 543734000018 Walker A/P-loop; other site 543734000019 ATP binding site [chemical binding]; other site 543734000020 Q-loop/lid; other site 543734000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000022 ABC transporter signature motif; other site 543734000023 Walker B; other site 543734000024 D-loop; other site 543734000025 H-loop/switch region; other site 543734000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 543734000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734000028 Mg2+ binding site [ion binding]; other site 543734000029 G-X-G motif; other site 543734000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 543734000031 anchoring element; other site 543734000032 dimer interface [polypeptide binding]; other site 543734000033 ATP binding site [chemical binding]; other site 543734000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 543734000035 active site 543734000036 metal binding site [ion binding]; metal-binding site 543734000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 543734000038 DNA gyrase subunit A; Validated; Region: PRK05560 543734000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 543734000040 CAP-like domain; other site 543734000041 active site 543734000042 primary dimer interface [polypeptide binding]; other site 543734000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734000049 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 543734000050 intersubunit interface [polypeptide binding]; other site 543734000051 active site 543734000052 catalytic residue [active] 543734000053 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 543734000054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 543734000055 dimer interface [polypeptide binding]; other site 543734000056 ssDNA binding site [nucleotide binding]; other site 543734000057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734000058 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 543734000059 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 543734000060 dimer interface [polypeptide binding]; other site 543734000061 ssDNA binding site [nucleotide binding]; other site 543734000062 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734000063 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 543734000064 MatE; Region: MatE; cl10513 543734000065 stage V sporulation protein B; Region: spore_V_B; TIGR02900 543734000066 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 543734000067 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 543734000068 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 543734000069 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 543734000070 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 543734000071 CAAX protease self-immunity; Region: Abi; cl00558 543734000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 543734000073 NlpC/P60 family; Region: NLPC_P60; cl11438 543734000074 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 543734000075 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 543734000076 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 543734000077 FtsX-like permease family; Region: FtsX; cl15850 543734000078 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734000079 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734000080 Walker A/P-loop; other site 543734000081 ATP binding site [chemical binding]; other site 543734000082 Q-loop/lid; other site 543734000083 ABC transporter signature motif; other site 543734000084 Walker B; other site 543734000085 D-loop; other site 543734000086 H-loop/switch region; other site 543734000087 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 543734000088 Helix-turn-helix domains; Region: HTH; cl00088 543734000089 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734000090 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734000091 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734000092 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 543734000093 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 543734000094 active site 543734000095 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 543734000096 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 543734000097 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 543734000098 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 543734000099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734000100 Helix-turn-helix domains; Region: HTH; cl00088 543734000101 hypothetical protein 543734000102 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 543734000103 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 543734000104 Peptidase family C69; Region: Peptidase_C69; pfam03577 543734000105 Enterocin A Immunity; Region: EntA_Immun; pfam08951 543734000106 AzlC protein; Region: AzlC; cl00570 543734000107 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 543734000108 CAAX protease self-immunity; Region: Abi; cl00558 543734000109 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 543734000110 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 543734000111 active site 543734000112 intersubunit interface [polypeptide binding]; other site 543734000113 catalytic residue [active] 543734000114 Transposase domain (DUF772); Region: DUF772; cl15789 543734000115 Transposase domain (DUF772); Region: DUF772; cl15789 543734000116 Transcriptional regulators [Transcription]; Region: GntR; COG1802 543734000117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734000118 DNA-binding site [nucleotide binding]; DNA binding site 543734000119 FCD domain; Region: FCD; cl11656 543734000120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734000121 non-specific DNA binding site [nucleotide binding]; other site 543734000122 salt bridge; other site 543734000123 sequence-specific DNA binding site [nucleotide binding]; other site 543734000124 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 543734000125 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 543734000126 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734000127 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 543734000128 Walker A/P-loop; other site 543734000129 ATP binding site [chemical binding]; other site 543734000130 Q-loop/lid; other site 543734000131 ABC transporter signature motif; other site 543734000132 Walker B; other site 543734000133 D-loop; other site 543734000134 H-loop/switch region; other site 543734000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734000137 putative substrate translocation pore; other site 543734000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000139 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 543734000140 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 543734000141 Transport protein; Region: actII; TIGR00833 543734000142 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 543734000143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734000144 Helix-turn-helix domains; Region: HTH; cl00088 543734000145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734000146 putative PBP binding loops; other site 543734000147 dimer interface [polypeptide binding]; other site 543734000148 ABC-ATPase subunit interface; other site 543734000149 NMT1-like family; Region: NMT1_2; cl15260 543734000150 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 543734000151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734000152 dimer interface [polypeptide binding]; other site 543734000153 conserved gate region; other site 543734000154 putative PBP binding loops; other site 543734000155 ABC-ATPase subunit interface; other site 543734000156 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 543734000157 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 543734000158 Walker A/P-loop; other site 543734000159 ATP binding site [chemical binding]; other site 543734000160 Q-loop/lid; other site 543734000161 ABC transporter signature motif; other site 543734000162 Walker B; other site 543734000163 D-loop; other site 543734000164 H-loop/switch region; other site 543734000165 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 543734000166 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 543734000167 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734000168 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734000169 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 543734000170 metal-binding site [ion binding] 543734000171 hypothetical protein 543734000172 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 543734000173 dinuclear metal binding motif [ion binding]; other site 543734000174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 543734000175 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 543734000176 ligand binding site [chemical binding]; other site 543734000177 flexible hinge region; other site 543734000178 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 543734000179 putative switch regulator; other site 543734000180 non-specific DNA interactions [nucleotide binding]; other site 543734000181 DNA binding site [nucleotide binding] 543734000182 sequence specific DNA binding site [nucleotide binding]; other site 543734000183 putative cAMP binding site [chemical binding]; other site 543734000184 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 543734000185 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 543734000186 substrate binding site [chemical binding]; other site 543734000187 active site 543734000188 catalytic residues [active] 543734000189 heterodimer interface [polypeptide binding]; other site 543734000190 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 543734000191 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 543734000192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734000193 catalytic residue [active] 543734000194 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 543734000195 active site 543734000196 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 543734000197 active site 543734000198 ribulose/triose binding site [chemical binding]; other site 543734000199 phosphate binding site [ion binding]; other site 543734000200 substrate (anthranilate) binding pocket [chemical binding]; other site 543734000201 product (indole) binding pocket [chemical binding]; other site 543734000202 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 543734000203 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 543734000204 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 543734000205 hypothetical protein 543734000206 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734000207 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 543734000208 P-loop; other site 543734000209 active site 543734000210 phosphorylation site [posttranslational modification] 543734000211 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734000212 active site 543734000213 phosphorylation site [posttranslational modification] 543734000214 hypothetical protein 543734000215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734000217 putative substrate translocation pore; other site 543734000218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000219 putative substrate translocation pore; other site 543734000220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734000221 Helix-turn-helix domains; Region: HTH; cl00088 543734000222 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 543734000223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000224 Walker A/P-loop; other site 543734000225 ATP binding site [chemical binding]; other site 543734000226 Q-loop/lid; other site 543734000227 ABC transporter signature motif; other site 543734000228 Walker B; other site 543734000229 D-loop; other site 543734000230 H-loop/switch region; other site 543734000231 PemK-like protein; Region: PemK; cl00995 543734000232 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 543734000233 active site 543734000234 hypothetical protein 543734000235 dihydrodipicolinate reductase; Provisional; Region: PRK00048 543734000236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000237 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 543734000238 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 543734000239 dihydrodipicolinate synthase; Region: dapA; TIGR00674 543734000240 dimer interface [polypeptide binding]; other site 543734000241 active site 543734000242 catalytic residue [active] 543734000243 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 543734000244 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 543734000245 metal binding site [ion binding]; metal-binding site 543734000246 putative dimer interface [polypeptide binding]; other site 543734000247 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 543734000248 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 543734000249 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 543734000250 putative trimer interface [polypeptide binding]; other site 543734000251 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 543734000252 putative CoA binding site [chemical binding]; other site 543734000253 putative trimer interface [polypeptide binding]; other site 543734000254 putative CoA binding site [chemical binding]; other site 543734000255 diaminopimelate decarboxylase; Region: lysA; TIGR01048 543734000256 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 543734000257 active site 543734000258 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 543734000259 substrate binding site [chemical binding]; other site 543734000260 catalytic residues [active] 543734000261 dimer interface [polypeptide binding]; other site 543734000262 aspartate kinase; Reviewed; Region: PRK09034 543734000263 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 543734000264 putative catalytic residues [active] 543734000265 putative nucleotide binding site [chemical binding]; other site 543734000266 putative aspartate binding site [chemical binding]; other site 543734000267 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 543734000268 allosteric regulatory residue; other site 543734000269 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 543734000270 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 543734000271 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 543734000272 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 543734000273 Mediator complex subunit 23; Region: Med23; pfam11573 543734000274 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 543734000275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000276 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 543734000277 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 543734000278 nudix motif; other site 543734000279 EamA-like transporter family; Region: EamA; cl01037 543734000280 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 543734000281 catalytic residues [active] 543734000282 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 543734000283 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 543734000284 DHH family; Region: DHH; pfam01368 543734000285 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 543734000286 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 543734000287 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 543734000288 replicative DNA helicase; Provisional; Region: PRK05748 543734000289 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 543734000290 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 543734000291 Walker A motif; other site 543734000292 ATP binding site [chemical binding]; other site 543734000293 Walker B motif; other site 543734000294 DNA binding loops [nucleotide binding] 543734000295 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 543734000296 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 543734000297 GDP-binding site [chemical binding]; other site 543734000298 ACT binding site; other site 543734000299 IMP binding site; other site 543734000300 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 543734000301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734000302 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734000303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734000304 dimerization interface [polypeptide binding]; other site 543734000305 putative DNA binding site [nucleotide binding]; other site 543734000306 putative Zn2+ binding site [ion binding]; other site 543734000307 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734000308 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 543734000309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734000310 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734000311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734000312 Helix-turn-helix domains; Region: HTH; cl00088 543734000313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734000314 dimerization interface [polypeptide binding]; other site 543734000315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734000316 non-specific DNA binding site [nucleotide binding]; other site 543734000317 salt bridge; other site 543734000318 sequence-specific DNA binding site [nucleotide binding]; other site 543734000319 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 543734000320 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734000321 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 543734000322 Walker A/P-loop; other site 543734000323 ATP binding site [chemical binding]; other site 543734000324 Q-loop/lid; other site 543734000325 ABC transporter signature motif; other site 543734000326 Walker B; other site 543734000327 D-loop; other site 543734000328 H-loop/switch region; other site 543734000329 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734000330 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 543734000331 ATP cone domain; Region: ATP-cone; pfam03477 543734000332 Class III ribonucleotide reductase; Region: RNR_III; cd01675 543734000333 effector binding site; other site 543734000334 active site 543734000335 Zn binding site [ion binding]; other site 543734000336 glycine loop; other site 543734000337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734000338 non-specific DNA binding site [nucleotide binding]; other site 543734000339 salt bridge; other site 543734000340 sequence-specific DNA binding site [nucleotide binding]; other site 543734000341 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 543734000342 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734000343 active site 543734000344 metal binding site [ion binding]; metal-binding site 543734000345 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 543734000346 FAD binding domain; Region: FAD_binding_4; pfam01565 543734000347 Transposase domain (DUF772); Region: DUF772; cl15789 543734000348 Transposase domain (DUF772); Region: DUF772; cl15789 543734000349 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 543734000350 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 543734000351 active site 543734000352 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 543734000353 putative dimer interface [polypeptide binding]; other site 543734000354 catalytic triad [active] 543734000355 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 543734000356 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 543734000357 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734000358 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 543734000359 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 543734000360 DNA binding site [nucleotide binding] 543734000361 active site 543734000362 D-lactate dehydrogenase; Validated; Region: PRK08605 543734000363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000364 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 543734000365 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 543734000366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000367 NAD(P) binding site [chemical binding]; other site 543734000368 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 543734000369 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 543734000370 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 543734000371 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734000372 Helix-turn-helix domains; Region: HTH; cl00088 543734000373 Integrase core domain; Region: rve; cl01316 543734000374 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 543734000375 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 543734000376 Zn binding site [ion binding]; other site 543734000377 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734000378 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734000379 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734000380 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734000381 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734000382 Helix-turn-helix domains; Region: HTH; cl00088 543734000383 Protein of unknown function (DUF805); Region: DUF805; cl01224 543734000384 Protein of unknown function (DUF805); Region: DUF805; cl01224 543734000385 recombination factor protein RarA; Reviewed; Region: PRK13342 543734000386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734000387 Walker A motif; other site 543734000388 ATP binding site [chemical binding]; other site 543734000389 Walker B motif; other site 543734000390 arginine finger; other site 543734000391 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 543734000392 Acetokinase family; Region: Acetate_kinase; cl01029 543734000393 propionate/acetate kinase; Provisional; Region: PRK12379 543734000394 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 543734000395 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734000396 active site 543734000397 metal binding site [ion binding]; metal-binding site 543734000398 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 543734000399 endonuclease III; Region: ENDO3c; smart00478 543734000400 minor groove reading motif; other site 543734000401 helix-hairpin-helix signature motif; other site 543734000402 substrate binding pocket [chemical binding]; other site 543734000403 active site 543734000404 Domain of unknown function DUF77; Region: DUF77; cl00307 543734000405 Predicted membrane protein [Function unknown]; Region: COG1511 543734000406 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 543734000407 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 543734000408 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 543734000409 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 543734000410 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 543734000411 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734000412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734000413 Helix-turn-helix domains; Region: HTH; cl00088 543734000414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734000416 putative substrate translocation pore; other site 543734000417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000418 putative phosphoketolase; Provisional; Region: PRK05261 543734000419 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 543734000420 TPP-binding site; other site 543734000421 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 543734000422 XFP C-terminal domain; Region: XFP_C; pfam09363 543734000423 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734000424 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734000425 peptide binding site [polypeptide binding]; other site 543734000426 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 543734000427 nudix motif; other site 543734000428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000429 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 543734000430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734000431 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734000432 Repair protein; Region: Repair_PSII; cl01535 543734000433 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 543734000434 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 543734000435 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 543734000436 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734000437 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 543734000438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000439 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 543734000440 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 543734000441 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 543734000442 Asp23 family; Region: Asp23; cl00574 543734000443 Asp23 family; Region: Asp23; cl00574 543734000444 Protein of unknown function (DUF969); Region: DUF969; cl01573 543734000445 Protein of unknown function (DUF979); Region: DUF979; cl01572 543734000446 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 543734000447 putative substrate binding pocket [chemical binding]; other site 543734000448 AC domain interface; other site 543734000449 catalytic triad [active] 543734000450 AB domain interface; other site 543734000451 interchain disulfide; other site 543734000452 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 543734000453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000454 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 543734000455 catalytic triad [active] 543734000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 543734000457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 543734000458 ParB-like partition proteins; Region: parB_part; TIGR00180 543734000459 ParB-like nuclease domain; Region: ParBc; cl02129 543734000460 KorB domain; Region: KorB; pfam08535 543734000461 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 543734000462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000463 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 543734000464 Magnesium ion binding site [ion binding]; other site 543734000465 ParB-like partition proteins; Region: parB_part; TIGR00180 543734000466 ParB-like nuclease domain; Region: ParBc; cl02129 543734000467 KorB domain; Region: KorB; pfam08535 543734000468 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 543734000469 GTP-binding protein YchF; Reviewed; Region: PRK09601 543734000470 YchF GTPase; Region: YchF; cd01900 543734000471 G1 box; other site 543734000472 GTP/Mg2+ binding site [chemical binding]; other site 543734000473 Switch I region; other site 543734000474 G2 box; other site 543734000475 Switch II region; other site 543734000476 G3 box; other site 543734000477 G4 box; other site 543734000478 G5 box; other site 543734000479 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 543734000480 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 543734000481 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 543734000482 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734000483 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 543734000484 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 543734000485 active site 543734000486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734000487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734000488 active site 543734000489 phosphorylation site [posttranslational modification] 543734000490 intermolecular recognition site; other site 543734000491 dimerization interface [polypeptide binding]; other site 543734000492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734000493 DNA binding site [nucleotide binding] 543734000494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734000495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 543734000496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734000497 dimer interface [polypeptide binding]; other site 543734000498 phosphorylation site [posttranslational modification] 543734000499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734000500 ATP binding site [chemical binding]; other site 543734000501 Mg2+ binding site [ion binding]; other site 543734000502 G-X-G motif; other site 543734000503 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 543734000504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734000505 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 543734000506 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 543734000507 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 543734000508 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 543734000509 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 543734000510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 543734000511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 543734000512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 543734000513 aspartate racemase; Region: asp_race; TIGR00035 543734000514 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 543734000515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734000516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734000517 active site 543734000518 catalytic tetrad [active] 543734000519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734000520 Helix-turn-helix domains; Region: HTH; cl00088 543734000521 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734000522 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 543734000523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000524 putative substrate translocation pore; other site 543734000525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000526 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 543734000527 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 543734000528 tetrameric interface [polypeptide binding]; other site 543734000529 NAD binding site [chemical binding]; other site 543734000530 catalytic residues [active] 543734000531 KduI/IolB family; Region: KduI; cl01508 543734000532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 543734000533 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 543734000534 substrate binding site [chemical binding]; other site 543734000535 ATP binding site [chemical binding]; other site 543734000536 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 543734000537 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 543734000538 PYR/PP interface [polypeptide binding]; other site 543734000539 dimer interface [polypeptide binding]; other site 543734000540 TPP binding site [chemical binding]; other site 543734000541 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 543734000542 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 543734000543 TPP-binding site; other site 543734000544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 543734000545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000546 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 543734000547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 543734000548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 543734000550 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 543734000551 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734000552 hypothetical protein; Provisional; Region: PRK08185 543734000553 active site 543734000554 intersubunit interface [polypeptide binding]; other site 543734000555 zinc binding site [ion binding]; other site 543734000556 Na+ binding site [ion binding]; other site 543734000557 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 543734000558 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 543734000559 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 543734000560 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 543734000561 putative active site [active] 543734000562 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 543734000563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000564 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 543734000565 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 543734000566 N- and C-terminal domain interface [polypeptide binding]; other site 543734000567 putative active site [active] 543734000568 catalytic site [active] 543734000569 metal binding site [ion binding]; metal-binding site 543734000570 carbohydrate binding site [chemical binding]; other site 543734000571 ATP binding site [chemical binding]; other site 543734000572 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 543734000573 Citrate transporter; Region: CitMHS; pfam03600 543734000574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 543734000575 active site 543734000576 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 543734000577 Probable Catalytic site; other site 543734000578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 543734000579 active site 543734000580 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 543734000581 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 543734000582 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 543734000583 active site 543734000584 SH3-like domain; Region: SH3_8; pfam13457 543734000585 SH3-like domain; Region: SH3_8; pfam13457 543734000586 SH3-like domain; Region: SH3_8; pfam13457 543734000587 SH3-like domain; Region: SH3_8; pfam13457 543734000588 SH3-like domain; Region: SH3_8; pfam13457 543734000589 SH3-like domain; Region: SH3_8; pfam13457 543734000590 SH3-like domain; Region: SH3_8; pfam13457 543734000591 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 543734000592 MatE; Region: MatE; cl10513 543734000593 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 543734000594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 543734000595 active site 543734000596 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 543734000597 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 543734000598 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 543734000599 putative PBP binding regions; other site 543734000600 ABC-ATPase subunit interface; other site 543734000601 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734000602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 543734000603 active site 543734000604 metal binding site [ion binding]; metal-binding site 543734000605 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 543734000606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000607 oligoendopeptidase F; Region: pepF; TIGR00181 543734000608 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 543734000609 active site 543734000610 Zn binding site [ion binding]; other site 543734000611 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 543734000612 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 543734000613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734000614 Helix-turn-helix domains; Region: HTH; cl00088 543734000615 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734000616 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 543734000617 active site 543734000618 Protein of unknown function (DUF975); Region: DUF975; cl10504 543734000619 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 543734000620 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 543734000621 Catalytic site [active] 543734000622 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 543734000623 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 543734000624 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 543734000625 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734000626 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734000627 ABC transporter; Region: ABC_tran_2; pfam12848 543734000628 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734000629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000630 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 543734000631 catalytic residues [active] 543734000632 Uncharacterized conserved protein [Function unknown]; Region: COG2966 543734000633 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734000634 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734000635 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 543734000636 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 543734000637 putative ligand binding site [chemical binding]; other site 543734000638 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 543734000639 TM-ABC transporter signature motif; other site 543734000640 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 543734000641 TM-ABC transporter signature motif; other site 543734000642 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 543734000643 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 543734000644 Walker A/P-loop; other site 543734000645 ATP binding site [chemical binding]; other site 543734000646 Q-loop/lid; other site 543734000647 ABC transporter signature motif; other site 543734000648 Walker B; other site 543734000649 D-loop; other site 543734000650 H-loop/switch region; other site 543734000651 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 543734000652 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 543734000653 Walker A/P-loop; other site 543734000654 ATP binding site [chemical binding]; other site 543734000655 Q-loop/lid; other site 543734000656 ABC transporter signature motif; other site 543734000657 Walker B; other site 543734000658 D-loop; other site 543734000659 H-loop/switch region; other site 543734000660 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734000661 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734000662 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 543734000663 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734000664 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734000665 phosphate binding site [ion binding]; other site 543734000666 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 543734000667 intersubunit interface [polypeptide binding]; other site 543734000668 active site 543734000669 catalytic residue [active] 543734000670 Sulfatase; Region: Sulfatase; cl10460 543734000671 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 543734000672 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 543734000673 NlpC/P60 family; Region: NLPC_P60; cl11438 543734000674 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 543734000675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734000676 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 543734000677 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 543734000678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000679 DEAD_2; Region: DEAD_2; pfam06733 543734000680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734000682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 543734000683 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 543734000684 active site 543734000685 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 543734000686 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 543734000687 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734000688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734000689 DNA-binding site [nucleotide binding]; DNA binding site 543734000690 UTRA domain; Region: UTRA; cl01230 543734000691 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 543734000692 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 543734000693 dimer interface [polypeptide binding]; other site 543734000694 active site 543734000695 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 543734000696 putative active site [active] 543734000697 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 543734000698 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 543734000699 active site 543734000700 dimer interface [polypeptide binding]; other site 543734000701 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 543734000702 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 543734000703 active site 543734000704 phosphorylation site [posttranslational modification] 543734000705 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734000706 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734000707 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734000708 active pocket/dimerization site; other site 543734000709 active site 543734000710 phosphorylation site [posttranslational modification] 543734000711 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 543734000712 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 543734000713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734000714 Transposase domain (DUF772); Region: DUF772; cl15789 543734000715 Transposase domain (DUF772); Region: DUF772; cl15789 543734000716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734000718 homodimer interface [polypeptide binding]; other site 543734000719 catalytic residue [active] 543734000720 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 543734000721 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 543734000722 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 543734000723 active site 543734000724 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734000725 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 543734000726 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734000727 active site 543734000728 P-loop; other site 543734000729 phosphorylation site [posttranslational modification] 543734000730 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734000731 active site 543734000732 methionine cluster; other site 543734000733 phosphorylation site [posttranslational modification] 543734000734 metal binding site [ion binding]; metal-binding site 543734000735 exoaminopeptidase; Provisional; Region: PRK09961 543734000736 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 543734000737 oligomer interface [polypeptide binding]; other site 543734000738 active site 543734000739 metal binding site [ion binding]; metal-binding site 543734000740 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734000741 Helix-turn-helix domains; Region: HTH; cl00088 543734000742 PRD domain; Region: PRD; cl15445 543734000743 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 543734000744 P-loop; other site 543734000745 active site 543734000746 phosphorylation site [posttranslational modification] 543734000747 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734000748 active site 543734000749 phosphorylation site [posttranslational modification] 543734000750 peptidase T; Region: peptidase-T; TIGR01882 543734000751 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 543734000752 metal binding site [ion binding]; metal-binding site 543734000753 dimer interface [polypeptide binding]; other site 543734000754 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734000755 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734000756 peptide binding site [polypeptide binding]; other site 543734000757 Predicted acetyltransferase [General function prediction only]; Region: COG3153 543734000758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734000759 Coenzyme A binding pocket [chemical binding]; other site 543734000760 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 543734000761 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 543734000762 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734000763 Walker A/P-loop; other site 543734000764 ATP binding site [chemical binding]; other site 543734000765 Q-loop/lid; other site 543734000766 ABC transporter signature motif; other site 543734000767 Walker B; other site 543734000768 D-loop; other site 543734000769 H-loop/switch region; other site 543734000770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000771 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 543734000772 Walker A/P-loop; other site 543734000773 ATP binding site [chemical binding]; other site 543734000774 Q-loop/lid; other site 543734000775 ABC transporter signature motif; other site 543734000776 Walker B; other site 543734000777 D-loop; other site 543734000778 H-loop/switch region; other site 543734000779 Cobalt transport protein; Region: CbiQ; cl00463 543734000780 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 543734000781 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 543734000782 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 543734000783 substrate binding site [chemical binding]; other site 543734000784 multimerization interface [polypeptide binding]; other site 543734000785 ATP binding site [chemical binding]; other site 543734000786 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 543734000787 thiamine phosphate binding site [chemical binding]; other site 543734000788 active site 543734000789 pyrophosphate binding site [ion binding]; other site 543734000790 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 543734000791 dimer interface [polypeptide binding]; other site 543734000792 substrate binding site [chemical binding]; other site 543734000793 ATP binding site [chemical binding]; other site 543734000794 Amino acid permease; Region: AA_permease_2; pfam13520 543734000795 hypothetical protein 543734000796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734000797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734000798 DNA binding site [nucleotide binding] 543734000799 domain linker motif; other site 543734000800 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 543734000801 ligand binding site [chemical binding]; other site 543734000802 dimerization interface [polypeptide binding]; other site 543734000803 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 543734000804 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 543734000805 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 543734000806 Walker A/P-loop; other site 543734000807 ATP binding site [chemical binding]; other site 543734000808 Q-loop/lid; other site 543734000809 ABC transporter signature motif; other site 543734000810 Walker B; other site 543734000811 D-loop; other site 543734000812 H-loop/switch region; other site 543734000813 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 543734000814 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 543734000815 TM-ABC transporter signature motif; other site 543734000816 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 543734000817 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 543734000818 ligand binding site [chemical binding]; other site 543734000819 dimerization interface [polypeptide binding]; other site 543734000820 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 543734000821 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 543734000822 substrate binding site [chemical binding]; other site 543734000823 dimer interface [polypeptide binding]; other site 543734000824 ATP binding site [chemical binding]; other site 543734000825 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 543734000826 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 543734000827 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 543734000828 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 543734000829 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734000830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734000832 putative substrate translocation pore; other site 543734000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734000834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 543734000835 Helix-turn-helix domains; Region: HTH; cl00088 543734000836 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 543734000837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000838 ABC transporter signature motif; other site 543734000839 Walker B; other site 543734000840 D-loop; other site 543734000841 H-loop/switch region; other site 543734000842 Transposase domain (DUF772); Region: DUF772; cl15789 543734000843 Transposase domain (DUF772); Region: DUF772; cl15789 543734000844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000845 Walker A/P-loop; other site 543734000846 ATP binding site [chemical binding]; other site 543734000847 Q-loop/lid; other site 543734000848 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 543734000849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000851 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734000852 Helix-turn-helix domains; Region: HTH; cl00088 543734000853 PRD domain; Region: PRD; cl15445 543734000854 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 543734000855 P-loop; other site 543734000856 active site 543734000857 phosphorylation site [posttranslational modification] 543734000858 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734000859 active site 543734000860 phosphorylation site [posttranslational modification] 543734000861 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 543734000862 P-loop; other site 543734000863 active site 543734000864 phosphorylation site [posttranslational modification] 543734000865 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734000866 hypothetical protein; Provisional; Region: PRK08185 543734000867 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734000868 intersubunit interface [polypeptide binding]; other site 543734000869 active site 543734000870 zinc binding site [ion binding]; other site 543734000871 Na+ binding site [ion binding]; other site 543734000872 Predicted kinase [General function prediction only]; Region: COG0645 543734000873 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734000874 Walker A motif; other site 543734000875 ATP binding site [chemical binding]; other site 543734000876 Helix-turn-helix domains; Region: HTH; cl00088 543734000877 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 543734000878 C-terminal domain interface [polypeptide binding]; other site 543734000879 sugar binding site [chemical binding]; other site 543734000880 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 543734000881 ornithine cyclodeaminase; Validated; Region: PRK08618 543734000882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734000883 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 543734000884 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734000885 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734000886 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734000887 Helix-turn-helix domains; Region: HTH; cl00088 543734000888 Helix-turn-helix domains; Region: HTH; cl00088 543734000889 Integrase core domain; Region: rve; cl01316 543734000890 hypothetical protein 543734000891 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734000892 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734000893 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734000894 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734000895 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734000896 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 543734000897 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 543734000898 Transposase domain (DUF772); Region: DUF772; cl15789 543734000899 Transposase domain (DUF772); Region: DUF772; cl15789 543734000900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734000901 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734000902 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734000903 DNA binding site [nucleotide binding] 543734000904 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 543734000905 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734000906 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734000907 Sulfatase; Region: Sulfatase; cl10460 543734000908 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734000909 Helix-turn-helix domains; Region: HTH; cl00088 543734000910 Helix-turn-helix domains; Region: HTH; cl00088 543734000911 Integrase core domain; Region: rve; cl01316 543734000912 potential protein location (hypothetical protein) that overlaps protein (transposase) 543734000913 hypothetical protein 543734000914 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 543734000915 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 543734000916 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 543734000917 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 543734000918 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 543734000919 active site 543734000920 tetramer interface [polypeptide binding]; other site 543734000921 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 543734000922 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 543734000923 FkbH-like domain; Region: FkbH; TIGR01686 543734000924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734000925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734000926 DNA-binding site [nucleotide binding]; DNA binding site 543734000927 Predicted esterase [General function prediction only]; Region: COG0627 543734000928 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734000929 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734000930 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734000931 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734000932 active site 543734000933 phosphorylation site [posttranslational modification] 543734000934 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734000935 active pocket/dimerization site; other site 543734000936 active site 543734000937 phosphorylation site [posttranslational modification] 543734000938 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 543734000939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734000940 Walker A motif; other site 543734000941 ATP binding site [chemical binding]; other site 543734000942 Walker B motif; other site 543734000943 arginine finger; other site 543734000944 Transcriptional antiterminator [Transcription]; Region: COG3933 543734000945 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734000946 active pocket/dimerization site; other site 543734000947 active site 543734000948 phosphorylation site [posttranslational modification] 543734000949 PRD domain; Region: PRD; cl15445 543734000950 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 543734000951 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 543734000952 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 543734000953 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 543734000954 Helix-turn-helix domains; Region: HTH; cl00088 543734000955 Helix-turn-helix domains; Region: HTH; cl00088 543734000956 PRD domain; Region: PRD; cl15445 543734000957 PRD domain; Region: PRD; cl15445 543734000958 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 543734000959 P-loop; other site 543734000960 active site 543734000961 phosphorylation site [posttranslational modification] 543734000962 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 543734000963 active site 543734000964 phosphorylation site [posttranslational modification] 543734000965 hypothetical protein; Provisional; Region: PRK08185 543734000966 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734000967 intersubunit interface [polypeptide binding]; other site 543734000968 active site 543734000969 zinc binding site [ion binding]; other site 543734000970 Na+ binding site [ion binding]; other site 543734000971 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734000972 active site 543734000973 phosphorylation site [posttranslational modification] 543734000974 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 543734000975 P-loop; other site 543734000976 active site 543734000977 phosphorylation site [posttranslational modification] 543734000978 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734000979 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 543734000980 active site 543734000981 catalytic residues [active] 543734000982 Cupin domain; Region: Cupin_2; cl09118 543734000983 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 543734000984 N- and C-terminal domain interface [polypeptide binding]; other site 543734000985 D-xylulose kinase; Region: XylB; TIGR01312 543734000986 active site 543734000987 catalytic site [active] 543734000988 metal binding site [ion binding]; metal-binding site 543734000989 xylulose binding site [chemical binding]; other site 543734000990 putative ATP binding site [chemical binding]; other site 543734000991 homodimer interface [polypeptide binding]; other site 543734000992 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734000993 Helix-turn-helix domains; Region: HTH; cl00088 543734000994 Integrase core domain; Region: rve; cl01316 543734000995 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734000996 active site 543734000997 phosphorylation site [posttranslational modification] 543734000998 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 543734000999 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 543734001000 P-loop; other site 543734001001 active site 543734001002 phosphorylation site [posttranslational modification] 543734001003 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001004 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 543734001005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734001006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734001007 homodimer interface [polypeptide binding]; other site 543734001008 catalytic residue [active] 543734001009 putative frv operon regulatory protein; Provisional; Region: PRK09863 543734001010 Helix-turn-helix domains; Region: HTH; cl00088 543734001011 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 543734001012 active site 543734001013 phosphorylation site [posttranslational modification] 543734001014 Helix-turn-helix domains; Region: HTH; cl00088 543734001015 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734001016 PRD domain; Region: PRD; cl15445 543734001017 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 543734001018 active site 543734001019 phosphorylation site [posttranslational modification] 543734001020 hypothetical protein; Provisional; Region: PRK08185 543734001021 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734001022 intersubunit interface [polypeptide binding]; other site 543734001023 active site 543734001024 zinc binding site [ion binding]; other site 543734001025 Na+ binding site [ion binding]; other site 543734001026 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 543734001027 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734001028 active site 543734001029 phosphorylation site [posttranslational modification] 543734001030 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 543734001031 P-loop; other site 543734001032 active site 543734001033 phosphorylation site [posttranslational modification] 543734001034 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001035 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734001036 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734001037 Integrase core domain; Region: rve; cl01316 543734001038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 543734001039 classical (c) SDRs; Region: SDR_c; cd05233 543734001040 NAD(P) binding site [chemical binding]; other site 543734001041 active site 543734001042 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734001043 active pocket/dimerization site; other site 543734001044 active site 543734001045 phosphorylation site [posttranslational modification] 543734001046 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734001047 active site 543734001048 phosphorylation site [posttranslational modification] 543734001049 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734001050 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734001051 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 543734001052 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 543734001053 DAK2 domain; Region: Dak2; cl03685 543734001054 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 543734001055 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 543734001056 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 543734001057 active site 543734001058 dimer interface [polypeptide binding]; other site 543734001059 magnesium binding site [ion binding]; other site 543734001060 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 543734001061 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 543734001062 tetramer interface [polypeptide binding]; other site 543734001063 active site 543734001064 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734001065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734001066 DNA-binding site [nucleotide binding]; DNA binding site 543734001067 UTRA domain; Region: UTRA; cl01230 543734001068 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 543734001069 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 543734001070 putative NAD(P) binding site [chemical binding]; other site 543734001071 catalytic Zn binding site [ion binding]; other site 543734001072 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 543734001073 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 543734001074 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 543734001075 classical (c) SDRs; Region: SDR_c; cd05233 543734001076 NAD(P) binding site [chemical binding]; other site 543734001077 active site 543734001078 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734001079 active pocket/dimerization site; other site 543734001080 active site 543734001081 phosphorylation site [posttranslational modification] 543734001082 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 543734001083 active site 543734001084 phosphorylation site [posttranslational modification] 543734001085 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734001086 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734001087 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734001088 hypothetical protein; Provisional; Region: PRK08185 543734001089 intersubunit interface [polypeptide binding]; other site 543734001090 active site 543734001091 zinc binding site [ion binding]; other site 543734001092 Na+ binding site [ion binding]; other site 543734001093 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 543734001094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734001095 transmembrane helices; other site 543734001096 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 543734001097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734001098 Helix-turn-helix domains; Region: HTH; cl00088 543734001099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734001100 dimerization interface [polypeptide binding]; other site 543734001101 Uncharacterized conserved protein [Function unknown]; Region: COG1912 543734001102 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 543734001103 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 543734001104 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 543734001105 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734001106 Walker A/P-loop; other site 543734001107 ATP binding site [chemical binding]; other site 543734001108 Q-loop/lid; other site 543734001109 ABC transporter signature motif; other site 543734001110 Walker B; other site 543734001111 D-loop; other site 543734001112 H-loop/switch region; other site 543734001113 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 543734001114 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 543734001115 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734001116 Walker A/P-loop; other site 543734001117 ATP binding site [chemical binding]; other site 543734001118 Q-loop/lid; other site 543734001119 ABC transporter signature motif; other site 543734001120 Walker B; other site 543734001121 D-loop; other site 543734001122 H-loop/switch region; other site 543734001123 Cobalt transport protein; Region: CbiQ; cl00463 543734001124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 543734001125 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 543734001126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001127 Transcriptional antiterminator [Transcription]; Region: COG3933 543734001128 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734001129 active pocket/dimerization site; other site 543734001130 active site 543734001131 phosphorylation site [posttranslational modification] 543734001132 PRD domain; Region: PRD; cl15445 543734001133 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734001134 active pocket/dimerization site; other site 543734001135 active site 543734001136 phosphorylation site [posttranslational modification] 543734001137 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734001138 active site 543734001139 phosphorylation site [posttranslational modification] 543734001140 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734001141 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734001142 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 543734001143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734001144 motif II; other site 543734001145 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734001146 Helix-turn-helix domains; Region: HTH; cl00088 543734001147 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734001148 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 543734001149 active site 543734001150 dimer interface [polypeptide binding]; other site 543734001151 magnesium binding site [ion binding]; other site 543734001152 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 543734001153 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 543734001154 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 543734001155 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001156 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 543734001157 active site 543734001158 P-loop; other site 543734001159 phosphorylation site [posttranslational modification] 543734001160 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734001161 active site 543734001162 phosphorylation site [posttranslational modification] 543734001163 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 543734001164 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 543734001165 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 543734001166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734001167 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 543734001168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 543734001169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001170 Walker A/P-loop; other site 543734001171 ATP binding site [chemical binding]; other site 543734001172 Q-loop/lid; other site 543734001173 ABC transporter signature motif; other site 543734001174 Walker B; other site 543734001175 D-loop; other site 543734001176 H-loop/switch region; other site 543734001177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734001178 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734001179 substrate binding pocket [chemical binding]; other site 543734001180 membrane-bound complex binding site; other site 543734001181 hinge residues; other site 543734001182 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734001183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734001184 dimer interface [polypeptide binding]; other site 543734001185 conserved gate region; other site 543734001186 putative PBP binding loops; other site 543734001187 ABC-ATPase subunit interface; other site 543734001188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734001189 dimer interface [polypeptide binding]; other site 543734001190 conserved gate region; other site 543734001191 putative PBP binding loops; other site 543734001192 ABC-ATPase subunit interface; other site 543734001193 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 543734001194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734001195 putative substrate translocation pore; other site 543734001196 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 543734001197 YvrJ protein family; Region: YvrJ; pfam12841 543734001198 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 543734001199 active site 543734001200 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 543734001201 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 543734001202 putative peptidoglycan binding site; other site 543734001203 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 543734001204 classical (c) SDRs; Region: SDR_c; cd05233 543734001205 NAD(P) binding site [chemical binding]; other site 543734001206 active site 543734001207 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734001208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734001209 Helix-turn-helix domains; Region: HTH; cl00088 543734001210 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 543734001211 FtsX-like permease family; Region: FtsX; cl15850 543734001212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734001213 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734001214 Walker A/P-loop; other site 543734001215 ATP binding site [chemical binding]; other site 543734001216 Q-loop/lid; other site 543734001217 ABC transporter signature motif; other site 543734001218 Walker B; other site 543734001219 D-loop; other site 543734001220 H-loop/switch region; other site 543734001221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734001222 non-specific DNA binding site [nucleotide binding]; other site 543734001223 salt bridge; other site 543734001224 sequence-specific DNA binding site [nucleotide binding]; other site 543734001225 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 543734001226 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 543734001227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734001228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734001229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734001230 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734001231 active site 543734001232 motif I; other site 543734001233 motif II; other site 543734001234 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734001235 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734001236 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 543734001237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734001238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734001239 DNA binding site [nucleotide binding] 543734001240 domain linker motif; other site 543734001241 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 543734001242 putative dimerization interface [polypeptide binding]; other site 543734001243 putative ligand binding site [chemical binding]; other site 543734001244 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734001245 active site 543734001246 phosphorylation site [posttranslational modification] 543734001247 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734001248 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734001249 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 543734001250 putative active site [active] 543734001251 putative catalytic site [active] 543734001252 putative alpha-glucosidase; Provisional; Region: PRK10658 543734001253 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734001254 active pocket/dimerization site; other site 543734001255 active site 543734001256 phosphorylation site [posttranslational modification] 543734001257 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734001258 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734001259 Ca binding site [ion binding]; other site 543734001260 active site 543734001261 catalytic site [active] 543734001262 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 543734001263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001264 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 543734001265 Walker A/P-loop; other site 543734001266 ATP binding site [chemical binding]; other site 543734001267 Q-loop/lid; other site 543734001268 ABC transporter signature motif; other site 543734001269 Walker B; other site 543734001270 D-loop; other site 543734001271 H-loop/switch region; other site 543734001272 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734001273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734001274 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734001275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001276 Walker A/P-loop; other site 543734001277 ATP binding site [chemical binding]; other site 543734001278 Q-loop/lid; other site 543734001279 ABC transporter signature motif; other site 543734001280 Walker B; other site 543734001281 D-loop; other site 543734001282 H-loop/switch region; other site 543734001283 Predicted membrane protein [Function unknown]; Region: COG1511 543734001284 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 543734001285 NMT1-like family; Region: NMT1_2; cl15260 543734001286 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 543734001287 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 543734001288 active site 543734001289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734001290 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 543734001291 Helix-turn-helix domains; Region: HTH; cl00088 543734001292 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734001293 DAK2 domain; Region: Dak2; cl03685 543734001294 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 543734001295 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 543734001296 OsmC-like protein; Region: OsmC; cl00767 543734001297 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 543734001298 active site 543734001299 substrate binding site [chemical binding]; other site 543734001300 catalytic site [active] 543734001301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734001302 dimerization interface [polypeptide binding]; other site 543734001303 putative DNA binding site [nucleotide binding]; other site 543734001304 putative Zn2+ binding site [ion binding]; other site 543734001305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734001306 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 543734001307 putative substrate translocation pore; other site 543734001308 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 543734001309 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734001310 hypothetical protein; Provisional; Region: PRK08185 543734001311 intersubunit interface [polypeptide binding]; other site 543734001312 active site 543734001313 zinc binding site [ion binding]; other site 543734001314 Na+ binding site [ion binding]; other site 543734001315 pyruvate oxidase; Provisional; Region: PRK08611 543734001316 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 543734001317 PYR/PP interface [polypeptide binding]; other site 543734001318 tetramer interface [polypeptide binding]; other site 543734001319 dimer interface [polypeptide binding]; other site 543734001320 TPP binding site [chemical binding]; other site 543734001321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 543734001322 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 543734001323 TPP-binding site [chemical binding]; other site 543734001324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734001325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734001326 S-adenosylmethionine binding site [chemical binding]; other site 543734001327 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 543734001328 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 543734001329 catalytic triad [active] 543734001330 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 543734001331 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 543734001332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 543734001333 amino acid transporter; Region: 2A0306; TIGR00909 543734001334 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 543734001335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 543734001336 DNA binding residues [nucleotide binding] 543734001337 putative dimer interface [polypeptide binding]; other site 543734001338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734001339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734001340 active site 543734001341 catalytic tetrad [active] 543734001342 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 543734001343 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 543734001344 putative NAD(P) binding site [chemical binding]; other site 543734001345 dimer interface [polypeptide binding]; other site 543734001346 Helix-turn-helix domains; Region: HTH; cl00088 543734001347 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734001348 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 543734001349 active site 543734001350 methionine cluster; other site 543734001351 phosphorylation site [posttranslational modification] 543734001352 metal binding site [ion binding]; metal-binding site 543734001353 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001354 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734001355 active site 543734001356 P-loop; other site 543734001357 phosphorylation site [posttranslational modification] 543734001358 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734001359 Helix-turn-helix domains; Region: HTH; cl00088 543734001360 Helix-turn-helix domains; Region: HTH; cl00088 543734001361 PRD domain; Region: PRD; cl15445 543734001362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734001363 active site 543734001364 phosphorylation site [posttranslational modification] 543734001365 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 543734001366 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 543734001367 catalytic residues [active] 543734001368 catalytic nucleophile [active] 543734001369 Presynaptic Site I dimer interface [polypeptide binding]; other site 543734001370 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 543734001371 Synaptic Flat tetramer interface [polypeptide binding]; other site 543734001372 Synaptic Site I dimer interface [polypeptide binding]; other site 543734001373 DNA binding site [nucleotide binding] 543734001374 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 543734001375 metal ion-dependent adhesion site (MIDAS); other site 543734001376 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734001377 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734001378 Gram positive anchor; Region: Gram_pos_anchor; cl15427 543734001379 Gram positive anchor; Region: Gram_pos_anchor; cl15427 543734001380 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 543734001381 active site 543734001382 catalytic site [active] 543734001383 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 543734001384 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734001385 Walker A/P-loop; other site 543734001386 ATP binding site [chemical binding]; other site 543734001387 Q-loop/lid; other site 543734001388 ABC transporter signature motif; other site 543734001389 Walker B; other site 543734001390 D-loop; other site 543734001391 H-loop/switch region; other site 543734001392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734001393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734001394 active site 543734001395 phosphorylation site [posttranslational modification] 543734001396 intermolecular recognition site; other site 543734001397 dimerization interface [polypeptide binding]; other site 543734001398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734001399 DNA binding site [nucleotide binding] 543734001400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734001401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 543734001402 dimerization interface [polypeptide binding]; other site 543734001403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734001404 dimer interface [polypeptide binding]; other site 543734001405 phosphorylation site [posttranslational modification] 543734001406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734001407 ATP binding site [chemical binding]; other site 543734001408 Mg2+ binding site [ion binding]; other site 543734001409 G-X-G motif; other site 543734001410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001411 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 543734001412 Walker A/P-loop; other site 543734001413 ATP binding site [chemical binding]; other site 543734001414 ABC transporter; Region: ABC_tran; pfam00005 543734001415 Q-loop/lid; other site 543734001416 ABC transporter signature motif; other site 543734001417 Walker B; other site 543734001418 D-loop; other site 543734001419 H-loop/switch region; other site 543734001420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 543734001421 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734001422 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 543734001423 putative active site [active] 543734001424 catalytic triad [active] 543734001425 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 543734001426 RNA polymerase sigma factor; Provisional; Region: PRK05901 543734001427 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734001428 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 543734001429 putative active site [active] 543734001430 catalytic triad [active] 543734001431 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 543734001432 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 543734001433 Peptidase family M1; Region: Peptidase_M1; pfam01433 543734001434 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 543734001435 Zn binding site [ion binding]; other site 543734001436 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 543734001437 inner membrane transporter YjeM; Provisional; Region: PRK15238 543734001438 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 543734001439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734001440 Helix-turn-helix domains; Region: HTH; cl00088 543734001441 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 543734001442 putative dimerization interface [polypeptide binding]; other site 543734001443 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 543734001444 classical (c) SDRs; Region: SDR_c; cd05233 543734001445 NAD(P) binding site [chemical binding]; other site 543734001446 active site 543734001447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734001448 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 543734001449 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 543734001450 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 543734001451 shikimate binding site; other site 543734001452 NAD(P) binding site [chemical binding]; other site 543734001453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734001454 putative substrate translocation pore; other site 543734001455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734001456 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 543734001457 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 543734001458 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 543734001459 shikimate binding site; other site 543734001460 NAD(P) binding site [chemical binding]; other site 543734001461 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 543734001462 proposed active site lysine [active] 543734001463 conserved cys residue [active] 543734001464 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 543734001465 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 543734001466 dimer interface [polypeptide binding]; other site 543734001467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734001468 catalytic residue [active] 543734001469 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734001470 Int/Topo IB signature motif; other site 543734001471 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 543734001472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 543734001473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734001474 non-specific DNA binding site [nucleotide binding]; other site 543734001475 salt bridge; other site 543734001476 sequence-specific DNA binding site [nucleotide binding]; other site 543734001477 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 543734001478 ORF6N domain; Region: ORF6N; pfam10543 543734001479 ORF6C domain; Region: ORF6C; pfam10552 543734001480 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 543734001481 Domain of unknown function (DUF771); Region: DUF771; cl09962 543734001482 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 543734001483 Helix-turn-helix domains; Region: HTH; cl00088 543734001484 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 543734001485 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 543734001486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734001487 Walker A motif; other site 543734001488 ATP binding site [chemical binding]; other site 543734001489 Walker B motif; other site 543734001490 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 543734001491 active site 543734001492 substrate binding site [chemical binding]; other site 543734001493 catalytic site [active] 543734001494 hypothetical protein 543734001495 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 543734001496 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734001497 Helix-turn-helix domains; Region: HTH; cl00088 543734001498 Helix-turn-helix domains; Region: HTH; cl00088 543734001499 Integrase core domain; Region: rve; cl01316 543734001500 GcrA cell cycle regulator; Region: GcrA; cl11564 543734001501 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 543734001502 Helix-turn-helix domains; Region: HTH; cl00088 543734001503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734001504 Helix-turn-helix domains; Region: HTH; cl00088 543734001505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734001506 Helix-turn-helix domains; Region: HTH; cl00088 543734001507 Helix-turn-helix domains; Region: HTH; cl00088 543734001508 putative transposase OrfB; Reviewed; Region: PHA02517 543734001509 HTH-like domain; Region: HTH_21; pfam13276 543734001510 Integrase core domain; Region: rve; cl01316 543734001511 Integrase core domain; Region: rve_3; cl15866 543734001512 HTH-like domain; Region: HTH_21; pfam13276 543734001513 Integrase core domain; Region: rve; cl01316 543734001514 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734001515 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 543734001516 generic binding surface II; other site 543734001517 generic binding surface I; other site 543734001518 AAA-like domain; Region: AAA_10; pfam12846 543734001519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001520 Walker A motif; other site 543734001521 ATP binding site [chemical binding]; other site 543734001522 Walker B motif; other site 543734001523 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 543734001524 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 543734001525 AAA-like domain; Region: AAA_10; pfam12846 543734001526 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 543734001527 NlpC/P60 family; Region: NLPC_P60; cl11438 543734001528 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 543734001529 catalytic residues [active] 543734001530 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 543734001531 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 543734001532 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 543734001533 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 543734001534 hypothetical protein 543734001535 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 543734001536 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 543734001537 active site 543734001538 catalytic site [active] 543734001539 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 543734001540 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 543734001541 Cl- selectivity filter; other site 543734001542 Cl- binding residues [ion binding]; other site 543734001543 pore gating glutamate residue; other site 543734001544 dimer interface [polypeptide binding]; other site 543734001545 H+/Cl- coupling transport residue; other site 543734001546 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734001547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 543734001548 Transposase domain (DUF772); Region: DUF772; cl15789 543734001549 Transposase domain (DUF772); Region: DUF772; cl15789 543734001550 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734001551 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734001552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734001553 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734001555 active site 543734001556 motif I; other site 543734001557 motif II; other site 543734001558 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734001559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 543734001560 Integrase core domain; Region: rve; cl01316 543734001561 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 543734001562 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 543734001563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 543734001564 Transposase domain (DUF772); Region: DUF772; cl15789 543734001565 Transposase domain (DUF772); Region: DUF772; cl15789 543734001566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 543734001567 Integrase core domain; Region: rve; cl01316 543734001568 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 543734001569 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 543734001570 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734001571 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734001572 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734001573 active site 543734001574 phosphorylation site [posttranslational modification] 543734001575 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734001576 active pocket/dimerization site; other site 543734001577 active site 543734001578 phosphorylation site [posttranslational modification] 543734001579 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 543734001580 intersubunit interface [polypeptide binding]; other site 543734001581 active site 543734001582 catalytic residue [active] 543734001583 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734001584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734001585 DNA-binding site [nucleotide binding]; DNA binding site 543734001586 UTRA domain; Region: UTRA; cl01230 543734001587 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 543734001588 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 543734001589 catalytic residues [active] 543734001590 catalytic nucleophile [active] 543734001591 Presynaptic Site I dimer interface [polypeptide binding]; other site 543734001592 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 543734001593 Synaptic Flat tetramer interface [polypeptide binding]; other site 543734001594 Synaptic Site I dimer interface [polypeptide binding]; other site 543734001595 DNA binding site [nucleotide binding] 543734001596 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 543734001597 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 543734001598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 543734001599 Transposase domain (DUF772); Region: DUF772; cl15789 543734001600 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 543734001601 Transposase domain (DUF772); Region: DUF772; cl15789 543734001602 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 543734001603 HTH-like domain; Region: HTH_21; pfam13276 543734001604 DDE domain; Region: DDE_Tnp_IS240; pfam13610 543734001605 Integrase core domain; Region: rve; cl01316 543734001606 Integrase core domain; Region: rve_3; cl15866 543734001607 Helix-turn-helix domains; Region: HTH; cl00088 543734001608 ApbE family; Region: ApbE; cl00643 543734001609 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734001610 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734001611 PAS domain; Region: PAS_10; pfam13596 543734001612 Helix-turn-helix domains; Region: HTH; cl00088 543734001613 HTH-like domain; Region: HTH_21; pfam13276 543734001614 DDE domain; Region: DDE_Tnp_IS240; pfam13610 543734001615 Integrase core domain; Region: rve; cl01316 543734001616 Integrase core domain; Region: rve_3; cl15866 543734001617 D-lactate dehydrogenase; Provisional; Region: PRK11183 543734001618 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 543734001619 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734001620 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734001621 Integrase core domain; Region: rve; cl01316 543734001622 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734001623 transmembrane helices; other site 543734001624 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 543734001625 Helix-turn-helix domains; Region: HTH; cl00088 543734001626 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 543734001627 active site 543734001628 Bacterial SH3 domain; Region: SH3_3; cl02551 543734001629 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 543734001630 putative peptidoglycan binding site; other site 543734001631 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 543734001632 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 543734001633 homodimer interface [polypeptide binding]; other site 543734001634 substrate-cofactor binding pocket; other site 543734001635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734001636 catalytic residue [active] 543734001637 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734001638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734001639 substrate binding pocket [chemical binding]; other site 543734001640 membrane-bound complex binding site; other site 543734001641 hinge residues; other site 543734001642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734001643 dimer interface [polypeptide binding]; other site 543734001644 conserved gate region; other site 543734001645 putative PBP binding loops; other site 543734001646 ABC-ATPase subunit interface; other site 543734001647 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 543734001648 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734001649 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734001650 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734001651 legume lectins; Region: lectin_L-type; cd01951 543734001652 homotetramer interaction site [polypeptide binding]; other site 543734001653 homodimer interaction site [polypeptide binding]; other site 543734001654 carbohydrate binding site [chemical binding]; other site 543734001655 metal binding site [ion binding]; metal-binding site 543734001656 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734001657 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734001658 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734001659 legume lectins; Region: lectin_L-type; cd01951 543734001660 homotetramer interaction site [polypeptide binding]; other site 543734001661 carbohydrate binding site [chemical binding]; other site 543734001662 metal binding site [ion binding]; metal-binding site 543734001663 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734001664 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 543734001665 EamA-like transporter family; Region: EamA; cl01037 543734001666 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 543734001667 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734001668 Walker A/P-loop; other site 543734001669 ATP binding site [chemical binding]; other site 543734001670 Q-loop/lid; other site 543734001671 ABC transporter signature motif; other site 543734001672 Walker B; other site 543734001673 D-loop; other site 543734001674 H-loop/switch region; other site 543734001675 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 543734001676 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 543734001677 substrate binding site [chemical binding]; other site 543734001678 ATP binding site [chemical binding]; other site 543734001679 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 543734001680 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 543734001681 FAD binding site [chemical binding]; other site 543734001682 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 543734001683 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 543734001684 THF binding site; other site 543734001685 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 543734001686 substrate binding site [chemical binding]; other site 543734001687 THF binding site; other site 543734001688 zinc-binding site [ion binding]; other site 543734001689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734001690 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734001691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001692 Walker A/P-loop; other site 543734001693 ATP binding site [chemical binding]; other site 543734001694 Q-loop/lid; other site 543734001695 ABC transporter signature motif; other site 543734001696 Walker B; other site 543734001697 D-loop; other site 543734001698 H-loop/switch region; other site 543734001699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734001700 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734001701 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 543734001702 Walker A/P-loop; other site 543734001703 ATP binding site [chemical binding]; other site 543734001704 Q-loop/lid; other site 543734001705 ABC transporter signature motif; other site 543734001706 Walker B; other site 543734001707 D-loop; other site 543734001708 H-loop/switch region; other site 543734001709 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 543734001710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734001711 putative substrate translocation pore; other site 543734001712 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 543734001713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734001714 DNA-binding site [nucleotide binding]; DNA binding site 543734001715 UTRA domain; Region: UTRA; cl01230 543734001716 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734001717 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734001718 Ca binding site [ion binding]; other site 543734001719 active site 543734001720 catalytic site [active] 543734001721 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 543734001722 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 543734001723 HPr interaction site; other site 543734001724 glycerol kinase (GK) interaction site [polypeptide binding]; other site 543734001725 active site 543734001726 phosphorylation site [posttranslational modification] 543734001727 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 543734001728 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 543734001729 active site turn [active] 543734001730 phosphorylation site [posttranslational modification] 543734001731 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001732 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 543734001733 amino acid transporter; Region: 2A0306; TIGR00909 543734001734 Spore germination protein; Region: Spore_permease; cl15802 543734001735 Spore germination protein; Region: Spore_permease; cl15802 543734001736 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 543734001737 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 543734001738 NAD binding site [chemical binding]; other site 543734001739 dimer interface [polypeptide binding]; other site 543734001740 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734001741 substrate binding site [chemical binding]; other site 543734001742 glutamate dehydrogenase; Provisional; Region: PRK09414 543734001743 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 543734001744 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 543734001745 NAD(P) binding site [chemical binding]; other site 543734001746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 543734001747 DNA-binding site [nucleotide binding]; DNA binding site 543734001748 RNA-binding motif; other site 543734001749 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 543734001750 OsmC-like protein; Region: OsmC; cl00767 543734001751 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 543734001752 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734001753 ABC transporter; Region: ABC_tran_2; pfam12848 543734001754 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734001755 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 543734001756 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734001757 NAD(P) binding site [chemical binding]; other site 543734001758 putative active site [active] 543734001759 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734001760 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734001761 active site 543734001762 catalytic tetrad [active] 543734001763 putative transport protein YifK; Provisional; Region: PRK10746 543734001764 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 543734001765 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 543734001766 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 543734001767 LytTr DNA-binding domain; Region: LytTR; cl04498 543734001768 Predicted membrane protein [Function unknown]; Region: COG1511 543734001769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734001770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001771 Walker A/P-loop; other site 543734001772 ATP binding site [chemical binding]; other site 543734001773 Q-loop/lid; other site 543734001774 ABC transporter signature motif; other site 543734001775 Walker B; other site 543734001776 D-loop; other site 543734001777 H-loop/switch region; other site 543734001778 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734001779 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 543734001780 active site 543734001781 zinc binding site [ion binding]; other site 543734001782 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 543734001783 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 543734001784 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 543734001785 putative NAD(P) binding site [chemical binding]; other site 543734001786 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 543734001787 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 543734001788 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 543734001789 MgtC family; Region: MgtC; pfam02308 543734001790 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 543734001791 Rhomboid family; Region: Rhomboid; cl11446 543734001792 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 543734001793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001794 Walker A/P-loop; other site 543734001795 ATP binding site [chemical binding]; other site 543734001796 ABC transporter signature motif; other site 543734001797 Walker B; other site 543734001798 D-loop; other site 543734001799 H-loop/switch region; other site 543734001800 ABC transporter; Region: ABC_tran_2; pfam12848 543734001801 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734001802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001803 Walker A/P-loop; other site 543734001804 ATP binding site [chemical binding]; other site 543734001805 Q-loop/lid; other site 543734001806 ABC transporter signature motif; other site 543734001807 Walker B; other site 543734001808 D-loop; other site 543734001809 H-loop/switch region; other site 543734001810 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 543734001811 putative uracil binding site [chemical binding]; other site 543734001812 putative active site [active] 543734001813 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 543734001814 amphipathic channel; other site 543734001815 Asn-Pro-Ala signature motifs; other site 543734001816 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 543734001817 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 543734001818 glycerol kinase; Provisional; Region: glpK; PRK00047 543734001819 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 543734001820 N- and C-terminal domain interface [polypeptide binding]; other site 543734001821 active site 543734001822 MgATP binding site [chemical binding]; other site 543734001823 catalytic site [active] 543734001824 metal binding site [ion binding]; metal-binding site 543734001825 glycerol binding site [chemical binding]; other site 543734001826 homotetramer interface [polypeptide binding]; other site 543734001827 homodimer interface [polypeptide binding]; other site 543734001828 FBP binding site [chemical binding]; other site 543734001829 protein IIAGlc interface [polypeptide binding]; other site 543734001830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 543734001831 active site 543734001832 CAT RNA binding domain; Region: CAT_RBD; cl03904 543734001833 transcriptional antiterminator BglG; Provisional; Region: PRK09772 543734001834 PRD domain; Region: PRD; cl15445 543734001835 PRD domain; Region: PRD; cl15445 543734001836 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734001837 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 543734001838 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 543734001839 P-loop; other site 543734001840 active site 543734001841 phosphorylation site [posttranslational modification] 543734001842 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734001843 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734001844 methionine cluster; other site 543734001845 active site 543734001846 phosphorylation site [posttranslational modification] 543734001847 metal binding site [ion binding]; metal-binding site 543734001848 galactokinase; Provisional; Region: PRK05322 543734001849 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 543734001850 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 543734001851 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 543734001852 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 543734001853 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 543734001854 NAD binding site [chemical binding]; other site 543734001855 homodimer interface [polypeptide binding]; other site 543734001856 active site 543734001857 substrate binding site [chemical binding]; other site 543734001858 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 543734001859 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 543734001860 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 543734001861 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 543734001862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734001863 DNA binding site [nucleotide binding] 543734001864 domain linker motif; other site 543734001865 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 543734001866 putative dimerization interface [polypeptide binding]; other site 543734001867 putative ligand binding site [chemical binding]; other site 543734001868 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 543734001869 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 543734001870 active site 543734001871 catalytic residues [active] 543734001872 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 543734001873 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734001874 active site 543734001875 phosphorylation site [posttranslational modification] 543734001876 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 543734001877 P-loop; other site 543734001878 active site 543734001879 phosphorylation site [posttranslational modification] 543734001880 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734001881 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 543734001882 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 543734001883 putative substrate binding site [chemical binding]; other site 543734001884 putative ATP binding site [chemical binding]; other site 543734001885 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734001886 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 543734001887 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 543734001888 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734001889 Helix-turn-helix domains; Region: HTH; cl00088 543734001890 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734001891 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 543734001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734001893 motif II; other site 543734001894 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 543734001895 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 543734001896 active site 543734001897 metal binding site [ion binding]; metal-binding site 543734001898 DNA binding site [nucleotide binding] 543734001899 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 543734001900 exonuclease SbcC; Region: sbcc; TIGR00618 543734001901 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 543734001902 Walker A/P-loop; other site 543734001903 ATP binding site [chemical binding]; other site 543734001904 Q-loop/lid; other site 543734001905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001906 ABC transporter signature motif; other site 543734001907 Walker B; other site 543734001908 D-loop; other site 543734001909 H-loop/switch region; other site 543734001910 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 543734001911 putative dimer interface [polypeptide binding]; other site 543734001912 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 543734001913 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 543734001914 minor groove reading motif; other site 543734001915 helix-hairpin-helix signature motif; other site 543734001916 substrate binding pocket [chemical binding]; other site 543734001917 active site 543734001918 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 543734001919 DNA binding and oxoG recognition site [nucleotide binding] 543734001920 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 543734001921 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734001922 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 543734001923 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 543734001924 dimer interface [polypeptide binding]; other site 543734001925 substrate binding site [chemical binding]; other site 543734001926 ATP binding site [chemical binding]; other site 543734001927 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 543734001928 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734001929 NAD binding site [chemical binding]; other site 543734001930 substrate binding site [chemical binding]; other site 543734001931 putative active site [active] 543734001932 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 543734001933 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 543734001934 Fibronectin type III-like domain; Region: Fn3-like; cl15273 543734001935 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 543734001936 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 543734001937 zinc binding site [ion binding]; other site 543734001938 putative ligand binding site [chemical binding]; other site 543734001939 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 543734001940 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 543734001941 zinc binding site [ion binding]; other site 543734001942 putative ligand binding site [chemical binding]; other site 543734001943 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 543734001944 TM-ABC transporter signature motif; other site 543734001945 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 543734001946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734001947 Walker A/P-loop; other site 543734001948 ATP binding site [chemical binding]; other site 543734001949 Q-loop/lid; other site 543734001950 ABC transporter signature motif; other site 543734001951 Walker B; other site 543734001952 D-loop; other site 543734001953 H-loop/switch region; other site 543734001954 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 543734001955 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 543734001956 NADP binding site [chemical binding]; other site 543734001957 dimer interface [polypeptide binding]; other site 543734001958 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734001959 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734001960 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734001961 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734001962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734001963 motif II; other site 543734001964 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734001965 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 543734001966 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 543734001967 Ligand binding site; other site 543734001968 Putative Catalytic site; other site 543734001969 DXD motif; other site 543734001970 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 543734001971 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 543734001972 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 543734001973 GtrA-like protein; Region: GtrA; cl00971 543734001974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734001976 active site 543734001977 phosphorylation site [posttranslational modification] 543734001978 intermolecular recognition site; other site 543734001979 dimerization interface [polypeptide binding]; other site 543734001980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734001981 DNA binding site [nucleotide binding] 543734001982 Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377 543734001983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734001984 dimer interface [polypeptide binding]; other site 543734001985 phosphorylation site [posttranslational modification] 543734001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734001987 ATP binding site [chemical binding]; other site 543734001988 Mg2+ binding site [ion binding]; other site 543734001989 G-X-G motif; other site 543734001990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 543734001991 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 543734001992 Helix-turn-helix domains; Region: HTH; cl00088 543734001993 hypothetical protein; Provisional; Region: PRK06194 543734001994 classical (c) SDRs; Region: SDR_c; cd05233 543734001995 NAD(P) binding site [chemical binding]; other site 543734001996 active site 543734001997 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 543734001998 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 543734001999 dimer interface [polypeptide binding]; other site 543734002000 FMN binding site [chemical binding]; other site 543734002001 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734002002 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 543734002003 phosphate binding site [ion binding]; other site 543734002004 Helix-turn-helix domains; Region: HTH; cl00088 543734002005 PQ loop repeat; Region: PQ-loop; cl12056 543734002006 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 543734002007 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 543734002008 putative NAD(P) binding site [chemical binding]; other site 543734002009 dimer interface [polypeptide binding]; other site 543734002010 Domain of unknown function DUF20; Region: UPF0118; pfam01594 543734002011 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 543734002012 LexA repressor; Validated; Region: PRK00215 543734002013 Helix-turn-helix domains; Region: HTH; cl00088 543734002014 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 543734002015 Catalytic site [active] 543734002016 Membrane transport protein; Region: Mem_trans; cl09117 543734002017 Flavin Reductases; Region: FlaRed; cl00801 543734002018 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 543734002019 Protein of unknown function, DUF488; Region: DUF488; cl01246 543734002020 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 543734002021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734002022 Helix-turn-helix domains; Region: HTH; cl00088 543734002023 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 543734002024 putative dimerization interface [polypeptide binding]; other site 543734002025 malate dehydrogenase; Provisional; Region: PRK13529 543734002026 Malic enzyme, N-terminal domain; Region: malic; pfam00390 543734002027 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 543734002028 NAD(P) binding site [chemical binding]; other site 543734002029 Membrane transport protein; Region: Mem_trans; cl09117 543734002030 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 543734002031 dimer interface [polypeptide binding]; other site 543734002032 catalytic triad [active] 543734002033 peroxidatic and resolving cysteines [active] 543734002034 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734002035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734002036 non-specific DNA binding site [nucleotide binding]; other site 543734002037 salt bridge; other site 543734002038 sequence-specific DNA binding site [nucleotide binding]; other site 543734002039 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 543734002040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734002041 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734002042 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 543734002043 Walker A/P-loop; other site 543734002044 ATP binding site [chemical binding]; other site 543734002045 Q-loop/lid; other site 543734002046 ABC transporter signature motif; other site 543734002047 Walker B; other site 543734002048 D-loop; other site 543734002049 H-loop/switch region; other site 543734002050 oligoendopeptidase F; Region: pepF; TIGR00181 543734002051 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 543734002052 active site 543734002053 Zn binding site [ion binding]; other site 543734002054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002055 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 543734002056 NAD(P) binding site [chemical binding]; other site 543734002057 active site 543734002058 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 543734002059 active site 543734002060 multimer interface [polypeptide binding]; other site 543734002061 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734002062 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734002063 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734002064 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 543734002065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 543734002066 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 543734002067 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 543734002068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002069 motif II; other site 543734002070 Helix-turn-helix domains; Region: HTH; cl00088 543734002071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734002072 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 543734002073 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734002074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734002075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734002076 active site 543734002077 catalytic tetrad [active] 543734002078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734002079 Protein of unknown function (DUF421); Region: DUF421; cl00990 543734002080 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 543734002081 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 543734002082 substrate binding site [chemical binding]; other site 543734002083 THF binding site; other site 543734002084 zinc-binding site [ion binding]; other site 543734002085 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 543734002086 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 543734002087 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 543734002088 RuvA N terminal domain; Region: RuvA_N; pfam01330 543734002089 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 543734002090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734002091 Walker A motif; other site 543734002092 ATP binding site [chemical binding]; other site 543734002093 Walker B motif; other site 543734002094 arginine finger; other site 543734002095 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 543734002096 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 543734002097 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 543734002098 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 543734002099 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 543734002100 Preprotein translocase subunit; Region: YajC; cl00806 543734002101 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 543734002102 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 543734002103 putative catalytic cysteine [active] 543734002104 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 543734002105 putative active site [active] 543734002106 metal binding site [ion binding]; metal-binding site 543734002107 Helix-turn-helix domains; Region: HTH; cl00088 543734002108 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 543734002109 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 543734002110 FeoA domain; Region: FeoA; cl00838 543734002111 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 543734002112 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 543734002113 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 543734002114 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 543734002115 active site 543734002116 DNA polymerase IV; Validated; Region: PRK02406 543734002117 DNA binding site [nucleotide binding] 543734002118 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 543734002119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734002120 DNA-binding site [nucleotide binding]; DNA binding site 543734002121 DRTGG domain; Region: DRTGG; cl12147 543734002122 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 543734002123 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 543734002124 DHH family; Region: DHH; pfam01368 543734002125 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 543734002126 DEAD-like helicases superfamily; Region: DEXDc; smart00487 543734002127 ATP binding site [chemical binding]; other site 543734002128 Mg++ binding site [ion binding]; other site 543734002129 motif III; other site 543734002130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734002131 nucleotide binding region [chemical binding]; other site 543734002132 ATP-binding site [chemical binding]; other site 543734002133 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 543734002134 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 543734002135 motif 1; other site 543734002136 active site 543734002137 motif 2; other site 543734002138 motif 3; other site 543734002139 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 543734002140 DHHA1 domain; Region: DHHA1; pfam02272 543734002141 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 543734002142 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 543734002143 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 543734002144 Cell division protein ZapA; Region: ZapA; cl01146 543734002145 Colicin V production protein; Region: Colicin_V; cl00567 543734002146 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 543734002147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002148 Walker A/P-loop; other site 543734002149 ATP binding site [chemical binding]; other site 543734002150 Q-loop/lid; other site 543734002151 ABC transporter signature motif; other site 543734002152 Walker B; other site 543734002153 D-loop; other site 543734002154 H-loop/switch region; other site 543734002155 V-type ATP synthase subunit H; Validated; Region: PRK06397 543734002156 Smr domain; Region: Smr; cl02619 543734002157 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 543734002158 catalytic residues [active] 543734002159 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 543734002160 AMP-binding enzyme; Region: AMP-binding; cl15778 543734002161 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 543734002162 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 543734002163 Phosphopantetheine attachment site; Region: PP-binding; cl09936 543734002164 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 543734002165 DltD N-terminal region; Region: DltD_N; pfam04915 543734002166 DltD central region; Region: DltD_M; pfam04918 543734002167 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 543734002168 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 543734002169 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 543734002170 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 543734002171 active site 543734002172 dimerization interface [polypeptide binding]; other site 543734002173 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 543734002174 active site 543734002175 metal binding site [ion binding]; metal-binding site 543734002176 homotetramer interface [polypeptide binding]; other site 543734002177 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 543734002178 amphipathic channel; other site 543734002179 Asn-Pro-Ala signature motifs; other site 543734002180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 543734002181 FOG: CBS domain [General function prediction only]; Region: COG0517 543734002182 Domain of unknown function (DUF368); Region: DUF368; cl00893 543734002183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 543734002184 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 543734002185 YtxH-like protein; Region: YtxH; cl02079 543734002186 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 543734002187 Helix-turn-helix domains; Region: HTH; cl00088 543734002188 3H domain; Region: 3H; pfam02829 543734002189 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 543734002190 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 543734002191 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 543734002192 active site 543734002193 catabolite control protein A; Region: ccpA; TIGR01481 543734002194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734002195 DNA binding site [nucleotide binding] 543734002196 domain linker motif; other site 543734002197 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 543734002198 dimerization interface [polypeptide binding]; other site 543734002199 effector binding site; other site 543734002200 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734002201 Helix-turn-helix domains; Region: HTH; cl00088 543734002202 Helix-turn-helix domains; Region: HTH; cl00088 543734002203 Integrase core domain; Region: rve; cl01316 543734002204 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734002205 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 543734002206 Transglycosylase; Region: Transgly; cl07896 543734002207 hypothetical protein 543734002208 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 543734002209 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734002210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002211 motif II; other site 543734002212 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 543734002213 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 543734002214 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 543734002215 dipeptidase PepV; Reviewed; Region: PRK07318 543734002216 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 543734002217 active site 543734002218 metal binding site [ion binding]; metal-binding site 543734002219 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 543734002220 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 543734002221 active site 543734002222 catalytic site [active] 543734002223 metal binding site [ion binding]; metal-binding site 543734002224 YibE/F-like protein; Region: YibE_F; cl02259 543734002225 YibE/F-like protein; Region: YibE_F; cl02259 543734002226 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 543734002227 putative active site [active] 543734002228 putative metal binding site [ion binding]; other site 543734002229 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 543734002230 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734002231 active site 543734002232 metal binding site [ion binding]; metal-binding site 543734002233 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 543734002234 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 543734002235 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 543734002236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002237 active site 543734002238 motif I; other site 543734002239 motif II; other site 543734002240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002241 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 543734002242 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 543734002243 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 543734002244 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 543734002245 tetramer interfaces [polypeptide binding]; other site 543734002246 binuclear metal-binding site [ion binding]; other site 543734002247 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 543734002248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734002251 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 543734002252 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 543734002253 active site 543734002254 general stress protein 13; Validated; Region: PRK08059 543734002255 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 543734002256 RNA binding site [nucleotide binding]; other site 543734002257 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734002258 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734002259 Integrase core domain; Region: rve; cl01316 543734002260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 543734002261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 543734002262 amino acid transporter; Region: 2A0306; TIGR00909 543734002263 Spore germination protein; Region: Spore_permease; cl15802 543734002264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 543734002265 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 543734002266 putative ADP-binding pocket [chemical binding]; other site 543734002267 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 543734002268 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 543734002269 Predicted integral membrane protein [Function unknown]; Region: COG0392 543734002270 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 543734002271 aromatic amino acid aminotransferase; Validated; Region: PRK07309 543734002272 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734002273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734002274 homodimer interface [polypeptide binding]; other site 543734002275 catalytic residue [active] 543734002276 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 543734002277 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 543734002278 Sulfatase; Region: Sulfatase; cl10460 543734002279 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 543734002280 metal binding site 2 [ion binding]; metal-binding site 543734002281 putative DNA binding helix; other site 543734002282 metal binding site 1 [ion binding]; metal-binding site 543734002283 dimer interface [polypeptide binding]; other site 543734002284 structural Zn2+ binding site [ion binding]; other site 543734002285 S-adenosylmethionine synthetase; Validated; Region: PRK05250 543734002286 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 543734002287 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 543734002288 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 543734002289 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734002291 putative substrate translocation pore; other site 543734002292 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 543734002293 DNA binding residues [nucleotide binding] 543734002294 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 543734002295 putative dimer interface [polypeptide binding]; other site 543734002296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734002297 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734002298 putative substrate translocation pore; other site 543734002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734002300 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 543734002301 active site 543734002302 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 543734002303 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 543734002304 HIGH motif; other site 543734002305 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 543734002306 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 543734002307 active site 543734002308 KMSKS motif; other site 543734002309 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 543734002310 tRNA binding surface [nucleotide binding]; other site 543734002311 MatE; Region: MatE; cl10513 543734002312 stage V sporulation protein B; Region: spore_V_B; TIGR02900 543734002313 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 543734002314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734002315 RNA binding surface [nucleotide binding]; other site 543734002316 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 543734002317 active site 543734002318 uracil binding [chemical binding]; other site 543734002319 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 543734002320 putative substrate binding site [chemical binding]; other site 543734002321 putative ATP binding site [chemical binding]; other site 543734002322 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 543734002323 nudix motif; other site 543734002324 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734002325 Int/Topo IB signature motif; other site 543734002326 Abi-like protein; Region: Abi_2; cl01988 543734002327 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 543734002328 Domain of unknown function (DUF955); Region: DUF955; cl01076 543734002329 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 543734002330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734002331 non-specific DNA binding site [nucleotide binding]; other site 543734002332 salt bridge; other site 543734002333 sequence-specific DNA binding site [nucleotide binding]; other site 543734002334 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 543734002335 Domain of unknown function (DUF771); Region: DUF771; cl09962 543734002336 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 543734002337 RecT family; Region: RecT; cl04285 543734002338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734002339 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 543734002340 Helix-turn-helix domains; Region: HTH; cl00088 543734002341 DNA-binding site [nucleotide binding]; DNA binding site 543734002342 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 543734002343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734002344 Walker A motif; other site 543734002345 ATP binding site [chemical binding]; other site 543734002346 Walker B motif; other site 543734002347 HNH endonuclease; Region: HNH_3; pfam13392 543734002348 Endodeoxyribonuclease RusA; Region: RusA; cl01885 543734002349 Helix-turn-helix domains; Region: HTH; cl00088 543734002350 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 543734002351 hypothetical protein; Provisional; Region: PRK11295 543734002352 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 543734002353 Phage Terminase; Region: Terminase_1; pfam03354 543734002354 Phage-related protein [Function unknown]; Region: COG4695; cl01923 543734002355 Phage portal protein; Region: Phage_portal; pfam04860 543734002356 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 543734002357 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 543734002358 oligomer interface [polypeptide binding]; other site 543734002359 active site residues [active] 543734002360 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 543734002361 Phage capsid family; Region: Phage_capsid; pfam05065 543734002362 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 543734002363 oligomerization interface [polypeptide binding]; other site 543734002364 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 543734002365 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 543734002366 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 543734002367 tape measure domain; Region: tape_meas_nterm; TIGR02675 543734002368 Phage-related protein [Function unknown]; Region: COG5412 543734002369 Phage-related protein [Function unknown]; Region: COG4722; cl15832 543734002370 Phage tail protein; Region: Sipho_tail; pfam05709 543734002371 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 543734002372 gp58-like protein; Region: Gp58; pfam07902 543734002373 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 543734002374 Bacteriophage holin; Region: Phage_holin_1; cl02344 543734002375 NlpC/P60 family; Region: NLPC_P60; cl11438 543734002376 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 543734002377 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 543734002378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 543734002379 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 543734002380 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 543734002381 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 543734002382 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 543734002383 catalytic residues [active] 543734002384 dimer interface [polypeptide binding]; other site 543734002385 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 543734002386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734002387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734002388 homodimer interface [polypeptide binding]; other site 543734002389 catalytic residue [active] 543734002390 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734002391 Helix-turn-helix domains; Region: HTH; cl00088 543734002392 Integrase core domain; Region: rve; cl01316 543734002393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734002394 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 543734002395 active site 543734002396 metal binding site [ion binding]; metal-binding site 543734002397 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 543734002398 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 543734002399 Competence protein CoiA-like family; Region: CoiA; cl11541 543734002400 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 543734002401 Thioredoxin; Region: Thioredoxin_5; pfam13743 543734002402 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 543734002403 putative active site [active] 543734002404 putative metal binding residues [ion binding]; other site 543734002405 signature motif; other site 543734002406 putative triphosphate binding site [ion binding]; other site 543734002407 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 543734002408 synthetase active site [active] 543734002409 NTP binding site [chemical binding]; other site 543734002410 metal binding site [ion binding]; metal-binding site 543734002411 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 543734002412 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 543734002413 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734002414 RNA binding surface [nucleotide binding]; other site 543734002415 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 543734002416 active site 543734002417 ApbE family; Region: ApbE; cl00643 543734002418 CutC family; Region: CutC; cl01218 543734002419 Bacitracin resistance protein BacA; Region: BacA; cl00858 543734002420 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 543734002421 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 543734002422 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 543734002423 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 543734002424 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 543734002425 active site 543734002426 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 543734002427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 543734002428 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 543734002429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734002430 S-adenosylmethionine binding site [chemical binding]; other site 543734002431 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 543734002432 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 543734002433 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 543734002434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002435 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 543734002436 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 543734002437 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 543734002438 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 543734002439 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 543734002440 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 543734002441 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 543734002442 classical (c) SDRs; Region: SDR_c; cd05233 543734002443 NAD(P) binding site [chemical binding]; other site 543734002444 active site 543734002445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734002446 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 543734002447 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 543734002448 competence damage-inducible protein A; Provisional; Region: PRK00549 543734002449 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 543734002450 putative MPT binding site; other site 543734002451 Competence-damaged protein; Region: CinA; cl00666 543734002452 recombinase A; Provisional; Region: recA; PRK09354 543734002453 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 543734002454 hexamer interface [polypeptide binding]; other site 543734002455 Walker A motif; other site 543734002456 ATP binding site [chemical binding]; other site 543734002457 Walker B motif; other site 543734002458 phosphodiesterase; Provisional; Region: PRK12704 543734002459 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734002460 Uncharacterized conserved protein [Function unknown]; Region: COG1739 543734002461 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 543734002462 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 543734002463 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 543734002464 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734002465 ATP binding site [chemical binding]; other site 543734002466 putative Mg++ binding site [ion binding]; other site 543734002467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734002468 nucleotide binding region [chemical binding]; other site 543734002469 ATP-binding site [chemical binding]; other site 543734002470 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 543734002471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734002472 active site 543734002473 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 543734002474 30S subunit binding site; other site 543734002475 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 543734002476 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 543734002477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734002478 nucleotide binding region [chemical binding]; other site 543734002479 ATP-binding site [chemical binding]; other site 543734002480 hypothetical protein 543734002481 peptide chain release factor 2; Provisional; Region: PRK05589 543734002482 RF-1 domain; Region: RF-1; cl02875 543734002483 RF-1 domain; Region: RF-1; cl02875 543734002484 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 543734002485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002486 Walker A/P-loop; other site 543734002487 ATP binding site [chemical binding]; other site 543734002488 Q-loop/lid; other site 543734002489 ABC transporter signature motif; other site 543734002490 Walker B; other site 543734002491 D-loop; other site 543734002492 H-loop/switch region; other site 543734002493 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 543734002494 FtsX-like permease family; Region: FtsX; cl15850 543734002495 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 543734002496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734002497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734002498 active site 543734002499 phosphorylation site [posttranslational modification] 543734002500 intermolecular recognition site; other site 543734002501 dimerization interface [polypeptide binding]; other site 543734002502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734002503 DNA binding site [nucleotide binding] 543734002504 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 543734002505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 543734002506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734002507 dimer interface [polypeptide binding]; other site 543734002508 phosphorylation site [posttranslational modification] 543734002509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734002510 ATP binding site [chemical binding]; other site 543734002511 Mg2+ binding site [ion binding]; other site 543734002512 G-X-G motif; other site 543734002513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734002514 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 543734002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002516 dimer interface [polypeptide binding]; other site 543734002517 conserved gate region; other site 543734002518 putative PBP binding loops; other site 543734002519 ABC-ATPase subunit interface; other site 543734002520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002521 dimer interface [polypeptide binding]; other site 543734002522 conserved gate region; other site 543734002523 putative PBP binding loops; other site 543734002524 ABC-ATPase subunit interface; other site 543734002525 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 543734002526 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 543734002527 Walker A/P-loop; other site 543734002528 ATP binding site [chemical binding]; other site 543734002529 Q-loop/lid; other site 543734002530 ABC transporter signature motif; other site 543734002531 Walker B; other site 543734002532 D-loop; other site 543734002533 H-loop/switch region; other site 543734002534 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 543734002535 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 543734002536 Walker A/P-loop; other site 543734002537 ATP binding site [chemical binding]; other site 543734002538 Q-loop/lid; other site 543734002539 ABC transporter signature motif; other site 543734002540 Walker B; other site 543734002541 D-loop; other site 543734002542 H-loop/switch region; other site 543734002543 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 543734002544 PhoU domain; Region: PhoU; pfam01895 543734002545 PhoU domain; Region: PhoU; pfam01895 543734002546 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 543734002547 Uncharacterized conserved protein [Function unknown]; Region: COG3595 543734002548 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 543734002549 Membrane protein of unknown function; Region: DUF360; cl00850 543734002550 HPr kinase/phosphorylase; Provisional; Region: PRK05428 543734002551 DRTGG domain; Region: DRTGG; cl12147 543734002552 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 543734002553 Hpr binding site; other site 543734002554 active site 543734002555 homohexamer subunit interaction site [polypeptide binding]; other site 543734002556 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 543734002557 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 543734002558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002559 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 543734002560 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 543734002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734002563 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 543734002564 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 543734002565 active site 543734002566 substrate binding site [chemical binding]; other site 543734002567 metal binding site [ion binding]; metal-binding site 543734002568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734002569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734002570 active site 543734002571 phosphorylation site [posttranslational modification] 543734002572 intermolecular recognition site; other site 543734002573 dimerization interface [polypeptide binding]; other site 543734002574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734002575 DNA binding site [nucleotide binding] 543734002576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734002577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 543734002578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734002579 ATP binding site [chemical binding]; other site 543734002580 Mg2+ binding site [ion binding]; other site 543734002581 G-X-G motif; other site 543734002582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002583 Walker A/P-loop; other site 543734002584 ATP binding site [chemical binding]; other site 543734002585 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734002586 Q-loop/lid; other site 543734002587 ABC transporter signature motif; other site 543734002588 Walker B; other site 543734002589 D-loop; other site 543734002590 H-loop/switch region; other site 543734002591 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 543734002592 FtsX-like permease family; Region: FtsX; cl15850 543734002593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734002594 excinuclease ABC subunit B; Provisional; Region: PRK05298 543734002595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734002596 ATP binding site [chemical binding]; other site 543734002597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734002598 nucleotide binding region [chemical binding]; other site 543734002599 ATP-binding site [chemical binding]; other site 543734002600 Ultra-violet resistance protein B; Region: UvrB; pfam12344 543734002601 UvrB/uvrC motif; Region: UVR; pfam02151 543734002602 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 543734002603 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 543734002604 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 543734002605 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 543734002606 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 543734002607 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 543734002608 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 543734002609 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 543734002610 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 543734002611 phosphate binding site [ion binding]; other site 543734002612 putative substrate binding pocket [chemical binding]; other site 543734002613 dimer interface [polypeptide binding]; other site 543734002614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 543734002615 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 543734002616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 543734002617 Helix-turn-helix domains; Region: HTH; cl00088 543734002618 Clp protease; Region: CLP_protease; pfam00574 543734002619 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 543734002620 oligomer interface [polypeptide binding]; other site 543734002621 active site residues [active] 543734002622 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 543734002623 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734002624 Int/Topo IB signature motif; other site 543734002625 Ion transport protein; Region: Ion_trans; pfam00520 543734002626 Ion channel; Region: Ion_trans_2; cl11596 543734002627 Short C-terminal domain; Region: SHOCT; cl01373 543734002628 Domain of unknown function (DUF955); Region: DUF955; cl01076 543734002629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734002630 non-specific DNA binding site [nucleotide binding]; other site 543734002631 salt bridge; other site 543734002632 sequence-specific DNA binding site [nucleotide binding]; other site 543734002633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734002634 ORF6N domain; Region: ORF6N; pfam10543 543734002635 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 543734002636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734002637 ATP binding site [chemical binding]; other site 543734002638 putative Mg++ binding site [ion binding]; other site 543734002639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734002640 nucleotide binding region [chemical binding]; other site 543734002641 ATP-binding site [chemical binding]; other site 543734002642 AAA domain; Region: AAA_24; pfam13479 543734002643 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 543734002644 polymerase nucleotide-binding site; other site 543734002645 DNA-binding residues [nucleotide binding]; DNA binding site 543734002646 nucleotide binding site [chemical binding]; other site 543734002647 primase nucleotide-binding site [nucleotide binding]; other site 543734002648 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 543734002649 Virulence-associated protein E; Region: VirE; pfam05272 543734002650 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 543734002651 HNH endonuclease; Region: HNH_3; pfam13392 543734002652 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 543734002653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 543734002654 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 543734002655 Phage Terminase; Region: Terminase_1; pfam03354 543734002656 Phage-related protein [Function unknown]; Region: COG4695; cl01923 543734002657 Phage portal protein; Region: Phage_portal; pfam04860 543734002658 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 543734002659 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 543734002660 oligomer interface [polypeptide binding]; other site 543734002661 active site residues [active] 543734002662 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 543734002663 Phage capsid family; Region: Phage_capsid; pfam05065 543734002664 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 543734002665 oligomerization interface [polypeptide binding]; other site 543734002666 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 543734002667 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 543734002668 Calcium binding and coiled-coil domain (CALCOCO1) like; Region: CALCOCO1; pfam07888 543734002669 Phage-related minor tail protein [Function unknown]; Region: COG5280 543734002670 Phage-related protein [Function unknown]; Region: COG5412 543734002671 Phage-related protein [Function unknown]; Region: COG4722; cl15832 543734002672 Phage tail protein; Region: Sipho_tail; pfam05709 543734002673 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 543734002674 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 543734002675 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 543734002676 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 543734002677 amidase catalytic site [active] 543734002678 Zn binding residues [ion binding]; other site 543734002679 substrate binding site [chemical binding]; other site 543734002680 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 543734002681 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 543734002682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734002683 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 543734002684 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 543734002685 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 543734002686 Phosphoglycerate kinase; Region: PGK; pfam00162 543734002687 substrate binding site [chemical binding]; other site 543734002688 hinge regions; other site 543734002689 ADP binding site [chemical binding]; other site 543734002690 catalytic site [active] 543734002691 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 543734002692 substrate binding site [chemical binding]; other site 543734002693 dimer interface [polypeptide binding]; other site 543734002694 catalytic triad [active] 543734002695 enolase; Provisional; Region: eno; PRK00077 543734002696 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 543734002697 dimer interface [polypeptide binding]; other site 543734002698 metal binding site [ion binding]; metal-binding site 543734002699 substrate binding pocket [chemical binding]; other site 543734002700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734002701 H+ Antiporter protein; Region: 2A0121; TIGR00900 543734002702 putative substrate translocation pore; other site 543734002703 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 543734002704 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 543734002705 Cl- selectivity filter; other site 543734002706 Cl- binding residues [ion binding]; other site 543734002707 pore gating glutamate residue; other site 543734002708 dimer interface [polypeptide binding]; other site 543734002709 H+/Cl- coupling transport residue; other site 543734002710 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734002711 Preprotein translocase SecG subunit; Region: SecG; cl09123 543734002712 Esterase/lipase [General function prediction only]; Region: COG1647 543734002713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734002714 ribonuclease R; Region: RNase_R; TIGR02063 543734002715 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 543734002716 RNB domain; Region: RNB; pfam00773 543734002717 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 543734002718 RNA binding site [nucleotide binding]; other site 543734002719 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 543734002720 SmpB-tmRNA interface; other site 543734002721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734002722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734002723 DNA binding site [nucleotide binding] 543734002724 domain linker motif; other site 543734002725 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 543734002726 ligand binding site [chemical binding]; other site 543734002727 dimerization interface [polypeptide binding]; other site 543734002728 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734002729 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734002730 Ca binding site [ion binding]; other site 543734002731 active site 543734002732 catalytic site [active] 543734002733 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 543734002734 homodimer interface [polypeptide binding]; other site 543734002735 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 543734002736 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 543734002737 active site 543734002738 homodimer interface [polypeptide binding]; other site 543734002739 catalytic site [active] 543734002740 maltose phosphorylase; Provisional; Region: PRK13807 543734002741 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 543734002742 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 543734002743 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 543734002744 beta-phosphoglucomutase; Region: bPGM; TIGR01990 543734002745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002746 motif II; other site 543734002747 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 543734002748 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 543734002749 Walker A/P-loop; other site 543734002750 ATP binding site [chemical binding]; other site 543734002751 Q-loop/lid; other site 543734002752 ABC transporter signature motif; other site 543734002753 Walker B; other site 543734002754 D-loop; other site 543734002755 H-loop/switch region; other site 543734002756 TOBE domain; Region: TOBE_2; cl01440 543734002757 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734002758 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734002759 Ca binding site [ion binding]; other site 543734002760 active site 543734002761 catalytic site [active] 543734002762 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 543734002763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734002764 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 543734002765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002766 dimer interface [polypeptide binding]; other site 543734002767 conserved gate region; other site 543734002768 putative PBP binding loops; other site 543734002769 ABC-ATPase subunit interface; other site 543734002770 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 543734002771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002772 dimer interface [polypeptide binding]; other site 543734002773 conserved gate region; other site 543734002774 ABC-ATPase subunit interface; other site 543734002775 ATP synthase regulation protein NCA2; Region: NCA2; pfam08637 543734002776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734002777 non-specific DNA binding site [nucleotide binding]; other site 543734002778 salt bridge; other site 543734002779 sequence-specific DNA binding site [nucleotide binding]; other site 543734002780 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 543734002781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734002782 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 543734002783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 543734002784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734002785 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 543734002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002787 dimer interface [polypeptide binding]; other site 543734002788 conserved gate region; other site 543734002789 putative PBP binding loops; other site 543734002790 ABC-ATPase subunit interface; other site 543734002791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002792 dimer interface [polypeptide binding]; other site 543734002793 conserved gate region; other site 543734002794 putative PBP binding loops; other site 543734002795 ABC-ATPase subunit interface; other site 543734002796 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 543734002797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002798 Walker A/P-loop; other site 543734002799 ATP binding site [chemical binding]; other site 543734002800 Q-loop/lid; other site 543734002801 ABC transporter signature motif; other site 543734002802 Walker B; other site 543734002803 D-loop; other site 543734002804 H-loop/switch region; other site 543734002805 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 543734002806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734002807 Coenzyme A binding pocket [chemical binding]; other site 543734002808 Scramblase; Region: Scramblase; cl02043 543734002809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002810 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734002811 active site 543734002812 motif I; other site 543734002813 motif II; other site 543734002814 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 543734002815 ligand binding site [chemical binding]; other site 543734002816 active site 543734002817 UGI interface [polypeptide binding]; other site 543734002818 catalytic site [active] 543734002819 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 543734002820 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 543734002821 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 543734002822 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 543734002823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002824 Walker A/P-loop; other site 543734002825 ATP binding site [chemical binding]; other site 543734002826 Q-loop/lid; other site 543734002827 ABC transporter signature motif; other site 543734002828 Walker B; other site 543734002829 D-loop; other site 543734002830 H-loop/switch region; other site 543734002831 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 543734002832 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 543734002833 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 543734002834 active site 543734002835 substrate binding site [chemical binding]; other site 543734002836 catalytic site [active] 543734002837 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 543734002838 active site 543734002839 DNA binding site [nucleotide binding] 543734002840 putative phosphate binding site [ion binding]; other site 543734002841 putative catalytic site [active] 543734002842 metal binding site A [ion binding]; metal-binding site 543734002843 AP binding site [nucleotide binding]; other site 543734002844 metal binding site B [ion binding]; metal-binding site 543734002845 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 543734002846 FAD binding domain; Region: FAD_binding_4; pfam01565 543734002847 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 543734002848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 543734002849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 543734002850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734002851 non-specific DNA binding site [nucleotide binding]; other site 543734002852 salt bridge; other site 543734002853 sequence-specific DNA binding site [nucleotide binding]; other site 543734002854 Cupin domain; Region: Cupin_2; cl09118 543734002855 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 543734002856 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 543734002857 Walker A/P-loop; other site 543734002858 ATP binding site [chemical binding]; other site 543734002859 Q-loop/lid; other site 543734002860 ABC transporter signature motif; other site 543734002861 Walker B; other site 543734002862 D-loop; other site 543734002863 H-loop/switch region; other site 543734002864 TOBE domain; Region: TOBE_2; cl01440 543734002865 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 543734002866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002867 dimer interface [polypeptide binding]; other site 543734002868 conserved gate region; other site 543734002869 putative PBP binding loops; other site 543734002870 ABC-ATPase subunit interface; other site 543734002871 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 543734002872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734002873 dimer interface [polypeptide binding]; other site 543734002874 conserved gate region; other site 543734002875 putative PBP binding loops; other site 543734002876 ABC-ATPase subunit interface; other site 543734002877 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 543734002878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734002879 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734002880 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734002881 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734002882 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734002883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734002884 motif II; other site 543734002885 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734002886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734002887 Helix-turn-helix domains; Region: HTH; cl00088 543734002888 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 543734002889 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734002890 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 543734002891 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 543734002892 Walker A/P-loop; other site 543734002893 ATP binding site [chemical binding]; other site 543734002894 Q-loop/lid; other site 543734002895 ABC transporter signature motif; other site 543734002896 Walker B; other site 543734002897 D-loop; other site 543734002898 H-loop/switch region; other site 543734002899 Uncharacterized conserved protein [Function unknown]; Region: COG1624 543734002900 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 543734002901 YbbR-like protein; Region: YbbR; pfam07949 543734002902 YbbR-like protein; Region: YbbR; pfam07949 543734002903 YbbR-like protein; Region: YbbR; pfam07949 543734002904 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 543734002905 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 543734002906 active site 543734002907 substrate binding site [chemical binding]; other site 543734002908 metal binding site [ion binding]; metal-binding site 543734002909 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 543734002910 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 543734002911 glutaminase active site [active] 543734002912 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 543734002913 dimer interface [polypeptide binding]; other site 543734002914 active site 543734002915 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 543734002916 dimer interface [polypeptide binding]; other site 543734002917 active site 543734002918 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 543734002919 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 543734002920 active site 543734002921 Zn binding site [ion binding]; other site 543734002922 Transcriptional regulator; Region: Transcrip_reg; cl00361 543734002923 Type II/IV secretion system protein; Region: T2SE; pfam00437 543734002924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002925 Walker A motif; other site 543734002926 ATP binding site [chemical binding]; other site 543734002927 Walker B motif; other site 543734002928 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 543734002929 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 543734002930 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 543734002931 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 543734002932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734002933 S-adenosylmethionine binding site [chemical binding]; other site 543734002934 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 543734002935 Spore germination protein; Region: Spore_permease; cl15802 543734002936 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734002937 putative acyl-acceptor binding pocket; other site 543734002938 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 543734002939 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 543734002940 Ligand binding site; other site 543734002941 metal-binding site 543734002942 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 543734002943 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 543734002944 Ligand binding site; other site 543734002945 metal-binding site 543734002946 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 543734002947 putative acyl-acceptor binding pocket; other site 543734002948 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 543734002949 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 543734002950 catalytic site [active] 543734002951 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 543734002952 SdpI/YhfL protein family; Region: SdpI; pfam13630 543734002953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734002954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734002955 active site 543734002956 phosphorylation site [posttranslational modification] 543734002957 intermolecular recognition site; other site 543734002958 dimerization interface [polypeptide binding]; other site 543734002959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734002960 DNA binding site [nucleotide binding] 543734002961 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 543734002962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734002963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 543734002964 dimerization interface [polypeptide binding]; other site 543734002965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734002966 dimer interface [polypeptide binding]; other site 543734002967 phosphorylation site [posttranslational modification] 543734002968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734002969 ATP binding site [chemical binding]; other site 543734002970 Mg2+ binding site [ion binding]; other site 543734002971 G-X-G motif; other site 543734002972 Predicted acetyltransferase [General function prediction only]; Region: COG3153 543734002973 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734002974 hypothetical protein; Provisional; Region: PRK04435 543734002975 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 543734002976 DNA polymerase IV; Reviewed; Region: PRK03103 543734002977 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 543734002978 active site 543734002979 DNA binding site [nucleotide binding] 543734002980 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 543734002981 Predicted membrane protein [Function unknown]; Region: COG4640 543734002982 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 543734002983 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 543734002984 active site 543734002985 catalytic triad [active] 543734002986 oxyanion hole [active] 543734002987 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 543734002988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734002989 Family description; Region: UvrD_C_2; cl15862 543734002990 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 543734002991 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 543734002992 nucleotide binding pocket [chemical binding]; other site 543734002993 K-X-D-G motif; other site 543734002994 catalytic site [active] 543734002995 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 543734002996 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 543734002997 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 543734002998 Dimer interface [polypeptide binding]; other site 543734002999 BRCT sequence motif; other site 543734003000 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 543734003001 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 543734003002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 543734003003 Amidase; Region: Amidase; cl11426 543734003004 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 543734003005 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 543734003006 GatB domain; Region: GatB_Yqey; cl11497 543734003007 putative lipid kinase; Reviewed; Region: PRK13055 543734003008 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 543734003009 TRAM domain; Region: TRAM; cl01282 543734003010 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 543734003011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 543734003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734003013 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734003014 putative substrate translocation pore; other site 543734003015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734003016 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734003017 active site 543734003018 motif I; other site 543734003019 motif II; other site 543734003020 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734003021 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 543734003022 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 543734003023 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 543734003024 active site 543734003025 Zn binding site [ion binding]; other site 543734003026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734003027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734003028 putative substrate translocation pore; other site 543734003029 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 543734003030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734003031 Coenzyme A binding pocket [chemical binding]; other site 543734003032 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 543734003033 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 543734003034 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 543734003035 active site 543734003036 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 543734003037 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 543734003038 formate dehydrogenase; Provisional; Region: PRK07574 543734003039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 543734003040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003041 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 543734003042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003043 ATP binding site [chemical binding]; other site 543734003044 putative Mg++ binding site [ion binding]; other site 543734003045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734003046 nucleotide binding region [chemical binding]; other site 543734003047 ATP-binding site [chemical binding]; other site 543734003048 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 543734003049 active site 543734003050 methionine cluster; other site 543734003051 phosphorylation site [posttranslational modification] 543734003052 metal binding site [ion binding]; metal-binding site 543734003053 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 543734003054 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 543734003055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734003056 ATP binding site [chemical binding]; other site 543734003057 putative Mg++ binding site [ion binding]; other site 543734003058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734003059 nucleotide binding region [chemical binding]; other site 543734003060 ATP-binding site [chemical binding]; other site 543734003061 RQC domain; Region: RQC; cl09632 543734003062 HRDC domain; Region: HRDC; cl02578 543734003063 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 543734003064 Helix-turn-helix domains; Region: HTH; cl00088 543734003065 WHG domain; Region: WHG; pfam13305 543734003066 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 543734003067 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 543734003068 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734003069 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 543734003070 active site 543734003071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 543734003072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 543734003073 active site 543734003074 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 543734003075 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 543734003076 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 543734003077 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 543734003078 active site 543734003079 tetramer interface; other site 543734003080 putative transposase OrfB; Reviewed; Region: PHA02517 543734003081 HTH-like domain; Region: HTH_21; pfam13276 543734003082 Integrase core domain; Region: rve; cl01316 543734003083 Integrase core domain; Region: rve_3; cl15866 543734003084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734003085 Helix-turn-helix domains; Region: HTH; cl00088 543734003086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734003087 Helix-turn-helix domains; Region: HTH; cl00088 543734003088 Helix-turn-helix domains; Region: HTH; cl00088 543734003089 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 543734003090 active site 543734003091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003092 NAD(P) binding site [chemical binding]; other site 543734003093 active site 543734003094 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734003095 Helix-turn-helix domains; Region: HTH; cl00088 543734003096 Helix-turn-helix domains; Region: HTH; cl00088 543734003097 Integrase core domain; Region: rve; cl01316 543734003098 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734003099 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734003100 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734003101 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 543734003102 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 543734003103 active site turn [active] 543734003104 phosphorylation site [posttranslational modification] 543734003105 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734003106 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 543734003107 HPr interaction site; other site 543734003108 glycerol kinase (GK) interaction site [polypeptide binding]; other site 543734003109 active site 543734003110 phosphorylation site [posttranslational modification] 543734003111 transcriptional antiterminator BglG; Provisional; Region: PRK09772 543734003112 CAT RNA binding domain; Region: CAT_RBD; cl03904 543734003113 PRD domain; Region: PRD; cl15445 543734003114 PRD domain; Region: PRD; cl15445 543734003115 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 543734003116 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 543734003117 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 543734003118 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 543734003119 Ligand binding site; other site 543734003120 Putative Catalytic site; other site 543734003121 DXD motif; other site 543734003122 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 543734003123 Predicted membrane protein [Function unknown]; Region: COG4129 543734003124 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 543734003125 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 543734003126 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 543734003127 DNA-binding site [nucleotide binding]; DNA binding site 543734003128 RNA-binding motif; other site 543734003129 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734003130 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 543734003131 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 543734003132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734003133 active site 543734003134 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 543734003135 xanthine permease; Region: pbuX; TIGR03173 543734003136 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734003137 adenylosuccinate lyase; Provisional; Region: PRK07492 543734003138 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 543734003139 tetramer interface [polypeptide binding]; other site 543734003140 active site 543734003141 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 543734003142 Sulfatase; Region: Sulfatase; cl10460 543734003143 VanZ like family; Region: VanZ; cl01971 543734003144 Sugar transport protein; Region: Sugar_transport; pfam06800 543734003145 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 543734003146 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 543734003147 active site 543734003148 dimer interface [polypeptide binding]; other site 543734003149 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 543734003150 dimer interface [polypeptide binding]; other site 543734003151 active site 543734003152 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 543734003153 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734003154 Int/Topo IB signature motif; other site 543734003155 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 543734003156 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 543734003157 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 543734003158 Domain of unknown function (DUF955); Region: DUF955; cl01076 543734003159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734003160 non-specific DNA binding site [nucleotide binding]; other site 543734003161 salt bridge; other site 543734003162 sequence-specific DNA binding site [nucleotide binding]; other site 543734003163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734003164 non-specific DNA binding site [nucleotide binding]; other site 543734003165 salt bridge; other site 543734003166 sequence-specific DNA binding site [nucleotide binding]; other site 543734003167 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 543734003168 RecT family; Region: RecT; cl04285 543734003169 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 543734003170 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 543734003171 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 543734003172 hypothetical protein 543734003173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734003174 non-specific DNA binding site [nucleotide binding]; other site 543734003175 salt bridge; other site 543734003176 sequence-specific DNA binding site [nucleotide binding]; other site 543734003177 Endodeoxyribonuclease RusA; Region: RusA; cl01885 543734003178 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 543734003179 GcrA cell cycle regulator; Region: GcrA; cl11564 543734003180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 543734003181 Terminase small subunit; Region: Terminase_2; cl01513 543734003182 Phage terminase large subunit; Region: Terminase_3; cl12054 543734003183 Terminase-like family; Region: Terminase_6; pfam03237 543734003184 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 543734003185 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 543734003186 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 543734003187 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 543734003188 hypothetical protein 543734003189 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 543734003190 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 543734003191 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 543734003192 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 543734003193 Phage major tail protein 2; Region: Phage_tail_2; cl11463 543734003194 Phage protein; Region: DUF3647; cl10335 543734003195 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 543734003196 Phage-related protein [Function unknown]; Region: COG5412 543734003197 Phage-related protein [Function unknown]; Region: COG4722; cl15832 543734003198 Phage tail protein; Region: Sipho_tail; pfam05709 543734003199 Phage tail protein; Region: Sipho_tail; pfam05709 543734003200 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 543734003201 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 543734003202 Bacteriophage holin; Region: Phage_holin_1; cl02344 543734003203 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 543734003204 active site 543734003205 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 543734003206 Bacterial SH3 domain; Region: SH3_3; cl02551 543734003207 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 543734003208 putative peptidoglycan binding site; other site 543734003209 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 543734003210 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 543734003211 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 543734003212 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 543734003213 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 543734003214 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734003215 Helix-turn-helix domains; Region: HTH; cl00088 543734003216 Helix-turn-helix domains; Region: HTH; cl00088 543734003217 Integrase core domain; Region: rve; cl01316 543734003218 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 543734003219 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 543734003220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 543734003222 nucleoside/Zn binding site; other site 543734003223 dimer interface [polypeptide binding]; other site 543734003224 catalytic motif [active] 543734003225 TspO/MBR family; Region: TspO_MBR; cl01379 543734003226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734003227 putative substrate translocation pore; other site 543734003228 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 543734003229 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 543734003230 Peptidase family C69; Region: Peptidase_C69; pfam03577 543734003231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734003232 catalytic core [active] 543734003233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734003234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734003235 Helix-turn-helix domains; Region: HTH; cl00088 543734003236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734003237 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734003238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003239 Walker A/P-loop; other site 543734003240 ATP binding site [chemical binding]; other site 543734003241 Q-loop/lid; other site 543734003242 ABC transporter signature motif; other site 543734003243 Walker B; other site 543734003244 D-loop; other site 543734003245 H-loop/switch region; other site 543734003246 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734003247 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 543734003248 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 543734003249 Walker A/P-loop; other site 543734003250 ATP binding site [chemical binding]; other site 543734003251 Q-loop/lid; other site 543734003252 ABC transporter signature motif; other site 543734003253 Walker B; other site 543734003254 D-loop; other site 543734003255 H-loop/switch region; other site 543734003256 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734003257 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 543734003258 putative metal binding site [ion binding]; other site 543734003259 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 543734003260 active site 543734003261 metal binding site [ion binding]; metal-binding site 543734003262 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734003263 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 543734003264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 543734003265 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 543734003266 thymidine kinase; Provisional; Region: PRK04296 543734003267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003268 ATP binding site [chemical binding]; other site 543734003269 Walker A motif; other site 543734003270 Walker B motif; other site 543734003271 peptide chain release factor 1; Validated; Region: prfA; PRK00591 543734003272 RF-1 domain; Region: RF-1; cl02875 543734003273 RF-1 domain; Region: RF-1; cl02875 543734003274 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 543734003275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734003276 S-adenosylmethionine binding site [chemical binding]; other site 543734003277 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 543734003278 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 543734003279 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 543734003280 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 543734003281 dimer interface [polypeptide binding]; other site 543734003282 glycine-pyridoxal phosphate binding site [chemical binding]; other site 543734003283 active site 543734003284 folate binding site [chemical binding]; other site 543734003285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734003286 active site 543734003287 ATP synthase A chain; Region: ATP-synt_A; cl00413 543734003288 ATP synthase subunit C; Region: ATP-synt_C; cl00466 543734003289 Plant ATP synthase F0; Region: YMF19; cl07975 543734003290 Plant ATP synthase F0; Region: YMF19; cl07975 543734003291 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 543734003292 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 543734003293 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 543734003294 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 543734003295 beta subunit interaction interface [polypeptide binding]; other site 543734003296 Walker A motif; other site 543734003297 ATP binding site [chemical binding]; other site 543734003298 Walker B motif; other site 543734003299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 543734003300 ATP synthase; Region: ATP-synt; cl00365 543734003301 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 543734003302 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 543734003303 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 543734003304 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 543734003305 alpha subunit interaction interface [polypeptide binding]; other site 543734003306 Walker A motif; other site 543734003307 ATP binding site [chemical binding]; other site 543734003308 Walker B motif; other site 543734003309 inhibitor binding site; inhibition site 543734003310 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 543734003311 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 543734003312 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 543734003313 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 543734003314 rod shape-determining protein MreB; Provisional; Region: PRK13930 543734003315 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 543734003316 ATP binding site [chemical binding]; other site 543734003317 profilin binding site; other site 543734003318 Haemolytic domain; Region: Haemolytic; cl00506 543734003319 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 543734003320 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 543734003321 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 543734003322 lipoyl attachment site [posttranslational modification]; other site 543734003323 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 543734003324 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 543734003325 metal binding site [ion binding]; metal-binding site 543734003326 dimer interface [polypeptide binding]; other site 543734003327 NMT1-like family; Region: NMT1_2; cl15260 543734003328 NMT1-like family; Region: NMT1_2; cl15260 543734003329 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 543734003330 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 543734003331 Walker A/P-loop; other site 543734003332 ATP binding site [chemical binding]; other site 543734003333 Q-loop/lid; other site 543734003334 ABC transporter signature motif; other site 543734003335 Walker B; other site 543734003336 D-loop; other site 543734003337 H-loop/switch region; other site 543734003338 NIL domain; Region: NIL; cl09633 543734003339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 543734003340 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 543734003341 FeS assembly ATPase SufC; Region: sufC; TIGR01978 543734003342 Walker A/P-loop; other site 543734003343 ATP binding site [chemical binding]; other site 543734003344 Q-loop/lid; other site 543734003345 ABC transporter signature motif; other site 543734003346 Walker B; other site 543734003347 D-loop; other site 543734003348 H-loop/switch region; other site 543734003349 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 543734003350 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 543734003351 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 543734003352 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 543734003353 catalytic residue [active] 543734003354 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 543734003355 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 543734003356 trimerization site [polypeptide binding]; other site 543734003357 active site 543734003358 FeS assembly protein SufB; Region: sufB; TIGR01980 543734003359 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 543734003360 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 543734003361 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 543734003362 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 543734003363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734003364 active site 543734003365 motif I; other site 543734003366 motif II; other site 543734003367 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 543734003368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734003369 non-specific DNA binding site [nucleotide binding]; other site 543734003370 salt bridge; other site 543734003371 sequence-specific DNA binding site [nucleotide binding]; other site 543734003372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 543734003373 Ligand Binding Site [chemical binding]; other site 543734003374 recombination factor protein RarA; Reviewed; Region: PRK13342 543734003375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734003376 Walker A motif; other site 543734003377 ATP binding site [chemical binding]; other site 543734003378 Walker B motif; other site 543734003379 arginine finger; other site 543734003380 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 543734003381 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 543734003382 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 543734003383 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 543734003384 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 543734003385 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 543734003386 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 543734003387 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 543734003388 putative L-serine binding site [chemical binding]; other site 543734003389 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 543734003390 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 543734003391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734003392 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 543734003393 catalytic core [active] 543734003394 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 543734003395 short chain dehydrogenase; Provisional; Region: PRK06197 543734003396 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 543734003397 putative NAD(P) binding site [chemical binding]; other site 543734003398 active site 543734003399 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 543734003400 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 543734003401 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 543734003402 Substrate-binding site [chemical binding]; other site 543734003403 Substrate specificity [chemical binding]; other site 543734003404 hypothetical protein; Provisional; Region: PRK07329 543734003405 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734003406 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734003407 peptide binding site [polypeptide binding]; other site 543734003408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734003409 dimer interface [polypeptide binding]; other site 543734003410 phosphorylation site [posttranslational modification] 543734003411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734003412 ATP binding site [chemical binding]; other site 543734003413 Mg2+ binding site [ion binding]; other site 543734003414 G-X-G motif; other site 543734003415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734003416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734003417 active site 543734003418 phosphorylation site [posttranslational modification] 543734003419 intermolecular recognition site; other site 543734003420 dimerization interface [polypeptide binding]; other site 543734003421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734003422 DNA binding site [nucleotide binding] 543734003423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734003424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003425 Walker A/P-loop; other site 543734003426 ATP binding site [chemical binding]; other site 543734003427 Q-loop/lid; other site 543734003428 ABC transporter signature motif; other site 543734003429 Walker B; other site 543734003430 D-loop; other site 543734003431 H-loop/switch region; other site 543734003432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734003433 Helix-turn-helix domains; Region: HTH; cl00088 543734003434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734003435 dimerization interface [polypeptide binding]; other site 543734003436 Cupin domain; Region: Cupin_2; cl09118 543734003437 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 543734003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003439 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734003440 NAD(P) binding site [chemical binding]; other site 543734003441 active site 543734003442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734003443 dimerization interface [polypeptide binding]; other site 543734003444 putative DNA binding site [nucleotide binding]; other site 543734003445 putative Zn2+ binding site [ion binding]; other site 543734003446 glutathionine S-transferase; Provisional; Region: PRK10542 543734003447 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 543734003448 C-terminal domain interface [polypeptide binding]; other site 543734003449 GSH binding site (G-site) [chemical binding]; other site 543734003450 dimer interface [polypeptide binding]; other site 543734003451 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 543734003452 dimer interface [polypeptide binding]; other site 543734003453 substrate binding pocket (H-site) [chemical binding]; other site 543734003454 N-terminal domain interface [polypeptide binding]; other site 543734003455 SAP domain; Region: SAP; cl02640 543734003456 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 543734003457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734003458 Coenzyme A binding pocket [chemical binding]; other site 543734003459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734003460 Coenzyme A binding pocket [chemical binding]; other site 543734003461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734003462 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 543734003463 Coenzyme A binding pocket [chemical binding]; other site 543734003464 hypothetical protein 543734003465 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 543734003466 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 543734003467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 543734003468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734003469 active site 543734003470 phosphorylation site [posttranslational modification] 543734003471 intermolecular recognition site; other site 543734003472 dimerization interface [polypeptide binding]; other site 543734003473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 543734003474 DNA binding residues [nucleotide binding] 543734003475 dimerization interface [polypeptide binding]; other site 543734003476 Histidine kinase; Region: HisKA_3; pfam07730 543734003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 543734003478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734003479 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734003480 Walker A/P-loop; other site 543734003481 ATP binding site [chemical binding]; other site 543734003482 Q-loop/lid; other site 543734003483 ABC transporter signature motif; other site 543734003484 Walker B; other site 543734003485 D-loop; other site 543734003486 H-loop/switch region; other site 543734003487 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 543734003488 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 543734003489 DNA binding residues [nucleotide binding] 543734003490 dimer interface [polypeptide binding]; other site 543734003491 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 543734003492 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 543734003493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734003494 Coenzyme A binding pocket [chemical binding]; other site 543734003495 RelB antitoxin; Region: RelB; cl01171 543734003496 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 543734003497 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 543734003498 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 543734003499 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 543734003500 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 543734003501 RNA binding site [nucleotide binding]; other site 543734003502 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734003503 Helix-turn-helix domains; Region: HTH; cl00088 543734003504 Integrase core domain; Region: rve; cl01316 543734003505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 543734003506 Transposase domain (DUF772); Region: DUF772; cl15789 543734003507 AAA-like domain; Region: AAA_10; pfam12846 543734003508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003509 Walker A motif; other site 543734003510 ATP binding site [chemical binding]; other site 543734003511 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 543734003512 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 543734003513 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 543734003514 Integrase core domain; Region: rve; cl01316 543734003515 Integrase core domain; Region: rve; cl01316 543734003516 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 543734003517 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 543734003518 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 543734003519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734003520 RNA binding surface [nucleotide binding]; other site 543734003521 GAF domain; Region: GAF; cl15785 543734003522 septation ring formation regulator EzrA; Provisional; Region: PRK04778 543734003523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734003524 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 543734003525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 543734003526 catalytic residue [active] 543734003527 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 543734003528 THUMP domain; Region: THUMP; cl12076 543734003529 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 543734003530 Ligand Binding Site [chemical binding]; other site 543734003531 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 543734003532 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 543734003533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003534 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 543734003535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 543734003536 active site 543734003537 HIGH motif; other site 543734003538 nucleotide binding site [chemical binding]; other site 543734003539 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 543734003540 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 543734003541 active site 543734003542 KMSKS motif; other site 543734003543 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 543734003544 tRNA binding surface [nucleotide binding]; other site 543734003545 anticodon binding site; other site 543734003546 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 543734003547 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 543734003548 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 543734003549 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 543734003550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734003551 motif II; other site 543734003552 hypothetical protein; Reviewed; Region: PRK00024 543734003553 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 543734003554 MPN+ (JAMM) motif; other site 543734003555 Zinc-binding site [ion binding]; other site 543734003556 rod shape-determining protein MreB; Provisional; Region: PRK13927 543734003557 Cell division protein FtsA; Region: FtsA; cl11496 543734003558 rod shape-determining protein MreC; Provisional; Region: PRK13922 543734003559 rod shape-determining protein MreC; Region: MreC; pfam04085 543734003560 rod shape-determining protein MreD; Region: MreD; cl01087 543734003561 septum formation inhibitor; Reviewed; Region: minC; PRK00513 543734003562 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 543734003563 septum site-determining protein MinD; Region: minD_bact; TIGR01968 543734003564 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 543734003565 Switch I; other site 543734003566 Switch II; other site 543734003567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734003568 dimer interface [polypeptide binding]; other site 543734003569 conserved gate region; other site 543734003570 putative PBP binding loops; other site 543734003571 ABC-ATPase subunit interface; other site 543734003572 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734003573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003574 Walker A/P-loop; other site 543734003575 ATP binding site [chemical binding]; other site 543734003576 Q-loop/lid; other site 543734003577 ABC transporter signature motif; other site 543734003578 Walker B; other site 543734003579 D-loop; other site 543734003580 H-loop/switch region; other site 543734003581 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734003582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734003583 substrate binding pocket [chemical binding]; other site 543734003584 membrane-bound complex binding site; other site 543734003585 hinge residues; other site 543734003586 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 543734003587 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 543734003588 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 543734003589 putative active site [active] 543734003590 catalytic site [active] 543734003591 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 543734003592 putative active site [active] 543734003593 catalytic site [active] 543734003594 cell division protein MraZ; Reviewed; Region: PRK00326 543734003595 MraZ protein; Region: MraZ; pfam02381 543734003596 MraZ protein; Region: MraZ; pfam02381 543734003597 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 543734003598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003599 Septum formation initiator; Region: DivIC; cl11433 543734003600 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 543734003601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 543734003602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734003603 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 543734003604 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 543734003605 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 543734003606 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 543734003607 Mg++ binding site [ion binding]; other site 543734003608 putative catalytic motif [active] 543734003609 putative substrate binding site [chemical binding]; other site 543734003610 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 543734003611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003612 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 543734003613 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 543734003614 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 543734003615 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 543734003616 active site 543734003617 homodimer interface [polypeptide binding]; other site 543734003618 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 543734003619 Cell division protein FtsQ; Region: FtsQ; pfam03799 543734003620 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 543734003621 Cell division protein FtsA; Region: FtsA; cl11496 543734003622 Cell division protein FtsA; Region: FtsA; cl11496 543734003623 cell division protein FtsZ; Validated; Region: PRK09330 543734003624 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 543734003625 nucleotide binding site [chemical binding]; other site 543734003626 SulA interaction site; other site 543734003627 Protein of unknown function (DUF552); Region: DUF552; cl00775 543734003628 YGGT family; Region: YGGT; cl00508 543734003629 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 543734003630 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734003631 RNA binding surface [nucleotide binding]; other site 543734003632 DivIVA protein; Region: DivIVA; pfam05103 543734003633 DivIVA domain; Region: DivI1A_domain; TIGR03544 543734003634 Plant ATP synthase F0; Region: YMF19; cl07975 543734003635 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 543734003636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 543734003637 active site 543734003638 HIGH motif; other site 543734003639 nucleotide binding site [chemical binding]; other site 543734003640 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 543734003641 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 543734003642 active site 543734003643 KMSKS motif; other site 543734003644 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 543734003645 tRNA binding surface [nucleotide binding]; other site 543734003646 anticodon binding site; other site 543734003647 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 543734003648 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 543734003649 DNA-binding site [nucleotide binding]; DNA binding site 543734003650 RNA-binding motif; other site 543734003651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734003652 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 543734003653 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734003654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734003655 putative substrate translocation pore; other site 543734003656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734003657 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 543734003658 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 543734003659 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 543734003660 dimer interface [polypeptide binding]; other site 543734003661 ADP-ribose binding site [chemical binding]; other site 543734003662 active site 543734003663 nudix motif; other site 543734003664 metal binding site [ion binding]; metal-binding site 543734003665 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 543734003666 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734003667 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 543734003668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 543734003669 catalytic residue [active] 543734003670 Putative amino acid metabolism; Region: DUF1831; pfam08866 543734003671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003672 Walker A/P-loop; other site 543734003673 ATP binding site [chemical binding]; other site 543734003674 Q-loop/lid; other site 543734003675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003676 ABC transporter signature motif; other site 543734003677 Walker B; other site 543734003678 D-loop; other site 543734003679 H-loop/switch region; other site 543734003680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003681 AAA domain; Region: AAA_21; pfam13304 543734003682 Walker A/P-loop; other site 543734003683 ATP binding site [chemical binding]; other site 543734003684 Q-loop/lid; other site 543734003685 ABC transporter signature motif; other site 543734003686 Walker B; other site 543734003687 D-loop; other site 543734003688 H-loop/switch region; other site 543734003689 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 543734003690 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 543734003691 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734003692 catalytic core [active] 543734003693 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 543734003694 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 543734003695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734003696 Family description; Region: UvrD_C_2; cl15862 543734003697 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734003698 Sterol carrier protein domain; Region: SCP2_2; pfam13530 543734003699 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 543734003700 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 543734003701 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 543734003702 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 543734003703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734003704 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 543734003705 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 543734003706 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 543734003707 active site 543734003708 catalytic residues [active] 543734003709 metal binding site [ion binding]; metal-binding site 543734003710 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734003711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734003712 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 543734003713 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 543734003714 TPP-binding site [chemical binding]; other site 543734003715 tetramer interface [polypeptide binding]; other site 543734003716 heterodimer interface [polypeptide binding]; other site 543734003717 phosphorylation loop region [posttranslational modification] 543734003718 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 543734003719 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 543734003720 alpha subunit interface [polypeptide binding]; other site 543734003721 TPP binding site [chemical binding]; other site 543734003722 heterodimer interface [polypeptide binding]; other site 543734003723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 543734003724 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 543734003725 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 543734003726 E3 interaction surface; other site 543734003727 lipoyl attachment site [posttranslational modification]; other site 543734003728 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 543734003729 E3 interaction surface; other site 543734003730 lipoyl attachment site [posttranslational modification]; other site 543734003731 e3 binding domain; Region: E3_binding; pfam02817 543734003732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 543734003733 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 543734003734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734003736 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734003737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003738 NAD(P) binding site [chemical binding]; other site 543734003739 substrate binding site [chemical binding]; other site 543734003740 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 543734003741 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 543734003742 active site 543734003743 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 543734003744 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 543734003745 G1 box; other site 543734003746 putative GEF interaction site [polypeptide binding]; other site 543734003747 GTP/Mg2+ binding site [chemical binding]; other site 543734003748 Switch I region; other site 543734003749 G2 box; other site 543734003750 G3 box; other site 543734003751 Switch II region; other site 543734003752 G4 box; other site 543734003753 G5 box; other site 543734003754 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 543734003755 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 543734003756 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 543734003757 pyruvate carboxylase; Reviewed; Region: PRK12999 543734003758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 543734003759 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734003760 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 543734003761 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 543734003762 active site 543734003763 catalytic residues [active] 543734003764 metal binding site [ion binding]; metal-binding site 543734003765 homodimer binding site [polypeptide binding]; other site 543734003766 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 543734003767 carboxyltransferase (CT) interaction site; other site 543734003768 biotinylation site [posttranslational modification]; other site 543734003769 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 543734003770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734003771 S-adenosylmethionine binding site [chemical binding]; other site 543734003772 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 543734003773 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 543734003774 active site 543734003775 (T/H)XGH motif; other site 543734003776 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 543734003777 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 543734003778 protein binding site [polypeptide binding]; other site 543734003779 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 543734003780 SLBB domain; Region: SLBB; pfam10531 543734003781 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 543734003782 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 543734003783 Competence protein; Region: Competence; cl00471 543734003784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734003785 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 543734003786 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 543734003787 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 543734003788 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 543734003789 16S/18S rRNA binding site [nucleotide binding]; other site 543734003790 S13e-L30e interaction site [polypeptide binding]; other site 543734003791 25S rRNA binding site [nucleotide binding]; other site 543734003792 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 543734003793 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734003794 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 543734003795 elongation factor Tu; Reviewed; Region: PRK00049 543734003796 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 543734003797 G1 box; other site 543734003798 GEF interaction site [polypeptide binding]; other site 543734003799 GTP/Mg2+ binding site [chemical binding]; other site 543734003800 Switch I region; other site 543734003801 G2 box; other site 543734003802 G3 box; other site 543734003803 Switch II region; other site 543734003804 G4 box; other site 543734003805 G5 box; other site 543734003806 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 543734003807 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 543734003808 Antibiotic Binding Site [chemical binding]; other site 543734003809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734003810 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734003811 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 543734003812 Walker A/P-loop; other site 543734003813 ATP binding site [chemical binding]; other site 543734003814 Q-loop/lid; other site 543734003815 ABC transporter signature motif; other site 543734003816 Walker B; other site 543734003817 D-loop; other site 543734003818 H-loop/switch region; other site 543734003819 trigger factor; Provisional; Region: tig; PRK01490 543734003820 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 543734003821 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 543734003822 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 543734003823 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 543734003824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734003825 Walker A motif; other site 543734003826 ATP binding site [chemical binding]; other site 543734003827 Walker B motif; other site 543734003828 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734003829 Predicted GTPase [General function prediction only]; Region: COG0218 543734003830 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 543734003831 G1 box; other site 543734003832 GTP/Mg2+ binding site [chemical binding]; other site 543734003833 Switch I region; other site 543734003834 G2 box; other site 543734003835 G3 box; other site 543734003836 Switch II region; other site 543734003837 G4 box; other site 543734003838 G5 box; other site 543734003839 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 543734003840 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734003841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734003842 substrate binding pocket [chemical binding]; other site 543734003843 membrane-bound complex binding site; other site 543734003844 hinge residues; other site 543734003845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734003846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734003847 dimer interface [polypeptide binding]; other site 543734003848 conserved gate region; other site 543734003849 putative PBP binding loops; other site 543734003850 ABC-ATPase subunit interface; other site 543734003851 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 543734003852 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 543734003853 Walker A/P-loop; other site 543734003854 ATP binding site [chemical binding]; other site 543734003855 Q-loop/lid; other site 543734003856 ABC transporter signature motif; other site 543734003857 Walker B; other site 543734003858 D-loop; other site 543734003859 H-loop/switch region; other site 543734003860 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 543734003861 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 543734003862 GIY-YIG motif/motif A; other site 543734003863 active site 543734003864 catalytic site [active] 543734003865 putative DNA binding site [nucleotide binding]; other site 543734003866 metal binding site [ion binding]; metal-binding site 543734003867 UvrB/uvrC motif; Region: UVR; pfam02151 543734003868 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 543734003869 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 543734003870 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734003871 active site 543734003872 phosphorylation site [posttranslational modification] 543734003873 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 543734003874 P-loop; other site 543734003875 active site 543734003876 phosphorylation site [posttranslational modification] 543734003877 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734003878 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 543734003879 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 543734003880 putative substrate binding site [chemical binding]; other site 543734003881 putative ATP binding site [chemical binding]; other site 543734003882 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734003883 Helix-turn-helix domains; Region: HTH; cl00088 543734003884 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734003885 GTPase CgtA; Reviewed; Region: obgE; PRK12297 543734003886 GTP1/OBG; Region: GTP1_OBG; pfam01018 543734003887 Obg GTPase; Region: Obg; cd01898 543734003888 G1 box; other site 543734003889 GTP/Mg2+ binding site [chemical binding]; other site 543734003890 Switch I region; other site 543734003891 G2 box; other site 543734003892 G3 box; other site 543734003893 Switch II region; other site 543734003894 G4 box; other site 543734003895 G5 box; other site 543734003896 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 543734003897 OpgC protein; Region: OpgC_C; cl00792 543734003898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 543734003899 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 543734003900 catalytic triad [active] 543734003901 catalytic triad [active] 543734003902 oxyanion hole [active] 543734003903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734003904 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 543734003905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734003906 NAD(P) binding site [chemical binding]; other site 543734003907 active site 543734003908 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 543734003909 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 543734003910 Clp amino terminal domain; Region: Clp_N; pfam02861 543734003911 Clp amino terminal domain; Region: Clp_N; pfam02861 543734003912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734003913 Walker A motif; other site 543734003914 ATP binding site [chemical binding]; other site 543734003915 Walker B motif; other site 543734003916 arginine finger; other site 543734003917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734003918 Walker A motif; other site 543734003919 ATP binding site [chemical binding]; other site 543734003920 Walker B motif; other site 543734003921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734003922 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 543734003923 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 543734003924 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 543734003925 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 543734003926 active site 543734003927 metal binding site [ion binding]; metal-binding site 543734003928 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 543734003929 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 543734003930 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 543734003931 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 543734003932 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 543734003933 generic binding surface I; other site 543734003934 generic binding surface II; other site 543734003935 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 543734003936 active site 543734003937 ADP/pyrophosphate binding site [chemical binding]; other site 543734003938 dimerization interface [polypeptide binding]; other site 543734003939 allosteric effector site; other site 543734003940 fructose-1,6-bisphosphate binding site; other site 543734003941 pyruvate kinase; Provisional; Region: PRK06354 543734003942 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 543734003943 domain interfaces; other site 543734003944 active site 543734003945 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 543734003946 Protein of unknown function (DUF441); Region: DUF441; cl01041 543734003947 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 543734003948 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 543734003949 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 543734003950 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 543734003951 Int/Topo IB signature motif; other site 543734003952 active site 543734003953 ScpA/B protein; Region: ScpA_ScpB; cl00598 543734003954 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 543734003955 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 543734003956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734003957 RNA binding surface [nucleotide binding]; other site 543734003958 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 543734003959 active site 543734003960 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 543734003961 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 543734003962 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 543734003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 543734003964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734003965 ATP binding site [chemical binding]; other site 543734003966 putative Mg++ binding site [ion binding]; other site 543734003967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734003968 nucleotide binding region [chemical binding]; other site 543734003969 ATP-binding site [chemical binding]; other site 543734003970 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 543734003971 putative peptidoglycan binding site; other site 543734003972 cytidylate kinase; Provisional; Region: cmk; PRK00023 543734003973 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 543734003974 CMP-binding site; other site 543734003975 The sites determining sugar specificity; other site 543734003976 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 543734003977 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 543734003978 RNA binding site [nucleotide binding]; other site 543734003979 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 543734003980 RNA binding site [nucleotide binding]; other site 543734003981 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 543734003982 RNA binding site [nucleotide binding]; other site 543734003983 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 543734003984 RNA binding site [nucleotide binding]; other site 543734003985 GTP-binding protein Der; Reviewed; Region: PRK00093 543734003986 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 543734003987 G1 box; other site 543734003988 GTP/Mg2+ binding site [chemical binding]; other site 543734003989 Switch I region; other site 543734003990 G2 box; other site 543734003991 Switch II region; other site 543734003992 G3 box; other site 543734003993 G4 box; other site 543734003994 G5 box; other site 543734003995 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 543734003996 G1 box; other site 543734003997 GTP/Mg2+ binding site [chemical binding]; other site 543734003998 Switch I region; other site 543734003999 G2 box; other site 543734004000 G3 box; other site 543734004001 Switch II region; other site 543734004002 G4 box; other site 543734004003 G5 box; other site 543734004004 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 543734004005 IHF dimer interface [polypeptide binding]; other site 543734004006 IHF - DNA interface [nucleotide binding]; other site 543734004007 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 543734004008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 543734004009 TPR motif; other site 543734004010 binding surface 543734004011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 543734004012 binding surface 543734004013 TPR motif; other site 543734004014 Uncharacterized conserved protein [Function unknown]; Region: COG1284 543734004015 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 543734004016 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 543734004017 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 543734004018 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 543734004019 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 543734004020 active site 543734004021 NTP binding site [chemical binding]; other site 543734004022 metal binding triad [ion binding]; metal-binding site 543734004023 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 543734004024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734004025 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 543734004026 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734004027 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734004028 ABC transporter; Region: ABC_tran_2; pfam12848 543734004029 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734004030 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 543734004031 dimerization interface [polypeptide binding]; other site 543734004032 active site 543734004033 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 543734004034 folate binding site [chemical binding]; other site 543734004035 NADP+ binding site [chemical binding]; other site 543734004036 Haemolysin-III related; Region: HlyIII; cl03831 543734004037 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 543734004038 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 543734004039 active site 543734004040 catalytic triad [active] 543734004041 oxyanion hole [active] 543734004042 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 543734004043 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 543734004044 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 543734004045 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 543734004046 C-terminal peptidase (prc); Region: prc; TIGR00225 543734004047 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 543734004048 protein binding site [polypeptide binding]; other site 543734004049 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 543734004050 Catalytic dyad [active] 543734004051 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 543734004052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004053 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 543734004054 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 543734004055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734004056 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 543734004057 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 543734004058 GTP/Mg2+ binding site [chemical binding]; other site 543734004059 G4 box; other site 543734004060 G5 box; other site 543734004061 G1 box; other site 543734004062 Switch I region; other site 543734004063 G2 box; other site 543734004064 G3 box; other site 543734004065 Switch II region; other site 543734004066 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 543734004067 RNA/DNA hybrid binding site [nucleotide binding]; other site 543734004068 active site 543734004069 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 543734004070 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 543734004071 DNA topoisomerase I; Validated; Region: PRK05582 543734004072 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 543734004073 active site 543734004074 interdomain interaction site; other site 543734004075 putative metal-binding site [ion binding]; other site 543734004076 nucleotide binding site [chemical binding]; other site 543734004077 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 543734004078 domain I; other site 543734004079 DNA binding groove [nucleotide binding] 543734004080 phosphate binding site [ion binding]; other site 543734004081 domain II; other site 543734004082 domain III; other site 543734004083 nucleotide binding site [chemical binding]; other site 543734004084 catalytic site [active] 543734004085 domain IV; other site 543734004086 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 543734004087 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 543734004088 DNA topoisomerase I; Validated; Region: PRK05582 543734004089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004090 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 543734004091 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 543734004092 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 543734004093 Int/Topo IB signature motif; other site 543734004094 active site 543734004095 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 543734004096 active site 543734004097 HslU subunit interaction site [polypeptide binding]; other site 543734004098 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 543734004099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734004100 Walker A motif; other site 543734004101 ATP binding site [chemical binding]; other site 543734004102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004103 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734004104 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 543734004105 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 543734004106 active site 543734004107 catalytic residues [active] 543734004108 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 543734004109 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 543734004110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 543734004111 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 543734004112 anchoring element; other site 543734004113 dimer interface [polypeptide binding]; other site 543734004114 ATP binding site [chemical binding]; other site 543734004115 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 543734004116 active site 543734004117 putative metal-binding site [ion binding]; other site 543734004118 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 543734004119 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 543734004120 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 543734004121 CAP-like domain; other site 543734004122 active site 543734004123 primary dimer interface [polypeptide binding]; other site 543734004124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 543734004125 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 543734004126 Pyruvate formate lyase 1; Region: PFL1; cd01678 543734004127 coenzyme A binding site [chemical binding]; other site 543734004128 active site 543734004129 catalytic residues [active] 543734004130 glycine loop; other site 543734004131 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 543734004132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 543734004133 FeS/SAM binding site; other site 543734004134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734004135 Helix-turn-helix domains; Region: HTH; cl00088 543734004136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734004137 dimerization interface [polypeptide binding]; other site 543734004138 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 543734004139 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 543734004140 DHHA2 domain; Region: DHHA2; pfam02833 543734004141 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 543734004142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 543734004143 DNA binding site [nucleotide binding] 543734004144 Int/Topo IB signature motif; other site 543734004145 active site 543734004146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734004147 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734004148 Walker A/P-loop; other site 543734004149 ATP binding site [chemical binding]; other site 543734004150 Q-loop/lid; other site 543734004151 ABC transporter signature motif; other site 543734004152 Walker B; other site 543734004153 D-loop; other site 543734004154 H-loop/switch region; other site 543734004155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734004156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734004157 ATP binding site [chemical binding]; other site 543734004158 Mg2+ binding site [ion binding]; other site 543734004159 G-X-G motif; other site 543734004160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734004161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734004162 active site 543734004163 phosphorylation site [posttranslational modification] 543734004164 intermolecular recognition site; other site 543734004165 dimerization interface [polypeptide binding]; other site 543734004166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734004167 DNA binding site [nucleotide binding] 543734004168 H+ Antiporter protein; Region: 2A0121; TIGR00900 543734004169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734004170 putative substrate translocation pore; other site 543734004171 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734004172 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 543734004173 dimer interface [polypeptide binding]; other site 543734004174 FMN binding site [chemical binding]; other site 543734004175 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 543734004176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734004177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734004178 homodimer interface [polypeptide binding]; other site 543734004179 catalytic residue [active] 543734004180 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 543734004181 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 543734004182 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 543734004183 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 543734004184 substrate binding site [chemical binding]; other site 543734004185 glutamase interaction surface [polypeptide binding]; other site 543734004186 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 543734004187 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 543734004188 catalytic residues [active] 543734004189 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 543734004190 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 543734004191 putative active site [active] 543734004192 oxyanion strand; other site 543734004193 catalytic triad [active] 543734004194 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 543734004195 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 543734004196 4-fold oligomerization interface [polypeptide binding]; other site 543734004197 putative active site pocket [active] 543734004198 metal binding residues [ion binding]; metal-binding site 543734004199 3-fold/trimer interface [polypeptide binding]; other site 543734004200 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 543734004201 histidinol dehydrogenase; Region: hisD; TIGR00069 543734004202 NAD binding site [chemical binding]; other site 543734004203 dimerization interface [polypeptide binding]; other site 543734004204 product binding site; other site 543734004205 substrate binding site [chemical binding]; other site 543734004206 zinc binding site [ion binding]; other site 543734004207 catalytic residues [active] 543734004208 ATP phosphoribosyltransferase; Region: HisG; cl15266 543734004209 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 543734004210 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 543734004211 dimer interface [polypeptide binding]; other site 543734004212 motif 1; other site 543734004213 active site 543734004214 motif 2; other site 543734004215 motif 3; other site 543734004216 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 543734004217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734004218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734004219 homodimer interface [polypeptide binding]; other site 543734004220 catalytic residue [active] 543734004221 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 543734004222 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 543734004223 dimer interface [polypeptide binding]; other site 543734004224 ADP-ribose binding site [chemical binding]; other site 543734004225 active site 543734004226 nudix motif; other site 543734004227 metal binding site [ion binding]; metal-binding site 543734004228 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 543734004229 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 543734004230 Domain of unknown function (DUF814); Region: DUF814; pfam05670 543734004231 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734004232 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 543734004233 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 543734004234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004235 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 543734004236 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 543734004237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 543734004238 E3 interaction surface; other site 543734004239 lipoyl attachment site [posttranslational modification]; other site 543734004240 e3 binding domain; Region: E3_binding; pfam02817 543734004241 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 543734004242 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 543734004243 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 543734004244 alpha subunit interface [polypeptide binding]; other site 543734004245 TPP binding site [chemical binding]; other site 543734004246 heterodimer interface [polypeptide binding]; other site 543734004247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 543734004248 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 543734004249 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 543734004250 tetramer interface [polypeptide binding]; other site 543734004251 TPP-binding site [chemical binding]; other site 543734004252 heterodimer interface [polypeptide binding]; other site 543734004253 phosphorylation loop region [posttranslational modification] 543734004254 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 543734004255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734004256 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734004257 Acetokinase family; Region: Acetate_kinase; cl01029 543734004258 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 543734004259 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 543734004260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734004261 active site 543734004262 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 543734004263 active site 543734004264 dimer interface [polypeptide binding]; other site 543734004265 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 543734004266 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 543734004267 heterodimer interface [polypeptide binding]; other site 543734004268 active site 543734004269 FMN binding site [chemical binding]; other site 543734004270 homodimer interface [polypeptide binding]; other site 543734004271 substrate binding site [chemical binding]; other site 543734004272 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 543734004273 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 543734004274 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734004275 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 543734004276 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 543734004277 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734004278 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 543734004279 IMP binding site; other site 543734004280 dimer interface [polypeptide binding]; other site 543734004281 interdomain contacts; other site 543734004282 partial ornithine binding site; other site 543734004283 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 543734004284 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 543734004285 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 543734004286 catalytic site [active] 543734004287 subunit interface [polypeptide binding]; other site 543734004288 dihydroorotase; Validated; Region: pyrC; PRK09357 543734004289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 543734004290 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 543734004291 active site 543734004292 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 543734004293 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 543734004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004295 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 543734004296 uracil transporter; Provisional; Region: PRK10720 543734004297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734004298 active site 543734004299 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 543734004300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734004301 RNA binding surface [nucleotide binding]; other site 543734004302 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 543734004303 active site 543734004304 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 543734004305 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 543734004306 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 543734004307 Potassium binding sites [ion binding]; other site 543734004308 Cesium cation binding sites [ion binding]; other site 543734004309 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 543734004310 RNA/DNA hybrid binding site [nucleotide binding]; other site 543734004311 active site 543734004312 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 543734004313 dimer interface [polypeptide binding]; other site 543734004314 FMN binding site [chemical binding]; other site 543734004315 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 543734004316 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 543734004317 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 543734004318 putative active site [active] 543734004319 catalytic site [active] 543734004320 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 543734004321 putative active site [active] 543734004322 catalytic site [active] 543734004323 Helix-turn-helix domains; Region: HTH; cl00088 543734004324 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 543734004325 catalytic residues [active] 543734004326 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 543734004327 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 543734004328 Class I ribonucleotide reductase; Region: RNR_I; cd01679 543734004329 active site 543734004330 dimer interface [polypeptide binding]; other site 543734004331 catalytic residues [active] 543734004332 effector binding site; other site 543734004333 R2 peptide binding site; other site 543734004334 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 543734004335 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 543734004336 dimer interface [polypeptide binding]; other site 543734004337 putative radical transfer pathway; other site 543734004338 diiron center [ion binding]; other site 543734004339 tyrosyl radical; other site 543734004340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734004341 Helix-turn-helix domains; Region: HTH; cl00088 543734004342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734004343 dimerization interface [polypeptide binding]; other site 543734004344 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 543734004345 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 543734004346 active site 543734004347 Zn binding site [ion binding]; other site 543734004348 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 543734004349 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 543734004350 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 543734004351 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 543734004352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004353 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 543734004354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004355 cell division protein GpsB; Provisional; Region: PRK14127 543734004356 DivIVA domain; Region: DivI1A_domain; TIGR03544 543734004357 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 543734004358 Recombination protein U; Region: RecU; cl01314 543734004359 Transglycosylase; Region: Transgly; cl07896 543734004360 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 543734004361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734004362 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 543734004363 catalytic motif [active] 543734004364 Zn binding site [ion binding]; other site 543734004365 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 543734004366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 543734004367 minor groove reading motif; other site 543734004368 helix-hairpin-helix signature motif; other site 543734004369 substrate binding pocket [chemical binding]; other site 543734004370 active site 543734004371 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 543734004372 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 543734004373 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 543734004374 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 543734004375 putative dimer interface [polypeptide binding]; other site 543734004376 putative anticodon binding site; other site 543734004377 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 543734004378 homodimer interface [polypeptide binding]; other site 543734004379 motif 1; other site 543734004380 motif 2; other site 543734004381 active site 543734004382 motif 3; other site 543734004383 aspartate aminotransferase; Provisional; Region: PRK05764 543734004384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734004385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734004386 homodimer interface [polypeptide binding]; other site 543734004387 catalytic residue [active] 543734004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 543734004389 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 543734004390 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 543734004391 active site 543734004392 substrate binding site [chemical binding]; other site 543734004393 catalytic site [active] 543734004394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004395 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 543734004396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004397 Family description; Region: UvrD_C_2; cl15862 543734004398 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 543734004399 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 543734004400 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 543734004401 mevalonate kinase; Region: mevalon_kin; TIGR00549 543734004402 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 543734004403 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 543734004404 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 543734004405 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 543734004406 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 543734004407 homotetramer interface [polypeptide binding]; other site 543734004408 FMN binding site [chemical binding]; other site 543734004409 homodimer contacts [polypeptide binding]; other site 543734004410 putative active site [active] 543734004411 putative substrate binding site [chemical binding]; other site 543734004412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 543734004413 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 543734004414 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 543734004415 Domain of unknown function DUF59; Region: DUF59; cl00941 543734004416 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 543734004417 active site 1 [active] 543734004418 dimer interface [polypeptide binding]; other site 543734004419 hexamer interface [polypeptide binding]; other site 543734004420 active site 2 [active] 543734004421 Uncharacterized conserved protein [Function unknown]; Region: COG0327 543734004422 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 543734004423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734004424 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 543734004425 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 543734004426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 543734004427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 543734004428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 543734004429 DNA binding residues [nucleotide binding] 543734004430 DNA primase; Validated; Region: dnaG; PRK05667 543734004431 CHC2 zinc finger; Region: zf-CHC2; cl15369 543734004432 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 543734004433 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 543734004434 active site 543734004435 metal binding site [ion binding]; metal-binding site 543734004436 interdomain interaction site; other site 543734004437 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 543734004438 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 543734004439 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 543734004440 dimer interface [polypeptide binding]; other site 543734004441 motif 2; other site 543734004442 active site 543734004443 motif 3; other site 543734004444 Recombination protein O N terminal; Region: RecO_N; cl15812 543734004445 DNA repair protein RecO; Region: reco; TIGR00613 543734004446 Recombination protein O C terminal; Region: RecO_C; pfam02565 543734004447 GTPase Era; Reviewed; Region: era; PRK00089 543734004448 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 543734004449 G1 box; other site 543734004450 GTP/Mg2+ binding site [chemical binding]; other site 543734004451 Switch I region; other site 543734004452 G2 box; other site 543734004453 Switch II region; other site 543734004454 G3 box; other site 543734004455 G4 box; other site 543734004456 G5 box; other site 543734004457 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 543734004458 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 543734004459 active site 543734004460 catalytic motif [active] 543734004461 Zn binding site [ion binding]; other site 543734004462 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 543734004463 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 543734004464 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 543734004465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004466 GatB domain; Region: GatB_Yqey; cl11497 543734004467 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 543734004468 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 543734004469 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 543734004470 endonuclease IV; Provisional; Region: PRK01060 543734004471 AP (apurinic/apyrimidinic) site pocket; other site 543734004472 DNA interaction; other site 543734004473 Metal-binding active site; metal-binding site 543734004474 Uncharacterized conserved protein [Function unknown]; Region: COG1284 543734004475 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 543734004476 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 543734004477 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 543734004478 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 543734004479 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 543734004480 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 543734004481 dimer interface [polypeptide binding]; other site 543734004482 anticodon binding site; other site 543734004483 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 543734004484 homodimer interface [polypeptide binding]; other site 543734004485 motif 1; other site 543734004486 active site 543734004487 motif 2; other site 543734004488 GAD domain; Region: GAD; pfam02938 543734004489 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 543734004490 motif 3; other site 543734004491 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 543734004492 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 543734004493 dimer interface [polypeptide binding]; other site 543734004494 motif 1; other site 543734004495 active site 543734004496 motif 2; other site 543734004497 motif 3; other site 543734004498 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 543734004499 anticodon binding site; other site 543734004500 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 543734004501 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 543734004502 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 543734004503 putative NAD(P) binding site [chemical binding]; other site 543734004504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734004505 non-specific DNA binding site [nucleotide binding]; other site 543734004506 salt bridge; other site 543734004507 sequence-specific DNA binding site [nucleotide binding]; other site 543734004508 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 543734004509 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 543734004510 Walker A/P-loop; other site 543734004511 ATP binding site [chemical binding]; other site 543734004512 Q-loop/lid; other site 543734004513 ABC transporter signature motif; other site 543734004514 Walker B; other site 543734004515 D-loop; other site 543734004516 H-loop/switch region; other site 543734004517 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 543734004518 Bacterial SH3 domain; Region: SH3_3; cl02551 543734004519 Bacterial SH3 domain; Region: SH3_3; cl02551 543734004520 Bacterial SH3 domain; Region: SH3_3; cl02551 543734004521 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 543734004522 active site 543734004523 metal binding site [ion binding]; metal-binding site 543734004524 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 543734004525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734004526 motif II; other site 543734004527 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 543734004528 putative active site [active] 543734004529 dimerization interface [polypeptide binding]; other site 543734004530 putative tRNAtyr binding site [nucleotide binding]; other site 543734004531 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 543734004532 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734004533 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 543734004534 synthetase active site [active] 543734004535 NTP binding site [chemical binding]; other site 543734004536 metal binding site [ion binding]; metal-binding site 543734004537 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 543734004538 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 543734004539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 543734004540 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 543734004541 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 543734004542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734004543 S-adenosylmethionine binding site [chemical binding]; other site 543734004544 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 543734004545 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 543734004546 active site 543734004547 DNA binding site [nucleotide binding] 543734004548 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 543734004549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734004550 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734004551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734004552 Helix-turn-helix domains; Region: HTH; cl00088 543734004553 N-formylglutamate amidohydrolase; Region: FGase; cl01522 543734004554 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 543734004555 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 543734004556 putative deacylase active site [active] 543734004557 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 543734004558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734004559 active site 543734004560 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 543734004561 DHH family; Region: DHH; pfam01368 543734004562 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 543734004563 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 543734004564 GTP-binding protein LepA; Provisional; Region: PRK05433 543734004565 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 543734004566 G1 box; other site 543734004567 putative GEF interaction site [polypeptide binding]; other site 543734004568 GTP/Mg2+ binding site [chemical binding]; other site 543734004569 Switch I region; other site 543734004570 G2 box; other site 543734004571 G3 box; other site 543734004572 Switch II region; other site 543734004573 G4 box; other site 543734004574 G5 box; other site 543734004575 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 543734004576 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 543734004577 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 543734004578 chaperone protein DnaJ; Provisional; Region: PRK14276 543734004579 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 543734004580 HSP70 interaction site [polypeptide binding]; other site 543734004581 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 543734004582 substrate binding site [polypeptide binding]; other site 543734004583 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 543734004584 Zn binding sites [ion binding]; other site 543734004585 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 543734004586 dimer interface [polypeptide binding]; other site 543734004587 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 543734004588 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 543734004589 dimer interface [polypeptide binding]; other site 543734004590 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 543734004591 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 543734004592 Helix-turn-helix domains; Region: HTH; cl00088 543734004593 HrcA protein C terminal domain; Region: HrcA; pfam01628 543734004594 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 543734004595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 543734004596 FeS/SAM binding site; other site 543734004597 HemN C-terminal domain; Region: HemN_C; pfam06969 543734004598 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 543734004599 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 543734004600 active site 543734004601 Riboflavin kinase; Region: Flavokinase; cl03312 543734004602 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 543734004603 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 543734004604 RNA binding site [nucleotide binding]; other site 543734004605 active site 543734004606 Integral membrane protein TerC family; Region: TerC; cl10468 543734004607 Ribosome-binding factor A; Region: RBFA; cl00542 543734004608 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 543734004609 translation initiation factor IF-2; Region: IF-2; TIGR00487 543734004610 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 543734004611 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 543734004612 G1 box; other site 543734004613 putative GEF interaction site [polypeptide binding]; other site 543734004614 GTP/Mg2+ binding site [chemical binding]; other site 543734004615 Switch I region; other site 543734004616 G2 box; other site 543734004617 G3 box; other site 543734004618 Switch II region; other site 543734004619 G4 box; other site 543734004620 G5 box; other site 543734004621 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 543734004622 Translation-initiation factor 2; Region: IF-2; pfam11987 543734004623 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 543734004624 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 543734004625 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 543734004626 putative RNA binding cleft [nucleotide binding]; other site 543734004627 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 543734004628 NusA N-terminal domain; Region: NusA_N; pfam08529 543734004629 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 543734004630 RNA binding site [nucleotide binding]; other site 543734004631 homodimer interface [polypeptide binding]; other site 543734004632 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 543734004633 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 543734004634 G-X-X-G motif; other site 543734004635 ribosome maturation protein RimP; Reviewed; Region: PRK00092 543734004636 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 543734004637 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 543734004638 Sm1 motif; other site 543734004639 predicted subunit interaction site [polypeptide binding]; other site 543734004640 RNA binding pocket [nucleotide binding]; other site 543734004641 Sm2 motif; other site 543734004642 DNA polymerase III PolC; Validated; Region: polC; PRK00448 543734004643 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 543734004644 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 543734004645 generic binding surface II; other site 543734004646 generic binding surface I; other site 543734004647 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 543734004648 active site 543734004649 substrate binding site [chemical binding]; other site 543734004650 catalytic site [active] 543734004651 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 543734004652 prolyl-tRNA synthetase; Provisional; Region: PRK09194 543734004653 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 543734004654 dimer interface [polypeptide binding]; other site 543734004655 motif 1; other site 543734004656 active site 543734004657 motif 2; other site 543734004658 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 543734004659 putative deacylase active site [active] 543734004660 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 543734004661 active site 543734004662 motif 3; other site 543734004663 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 543734004664 anticodon binding site; other site 543734004665 RIP metalloprotease RseP; Region: TIGR00054 543734004666 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 543734004667 active site 543734004668 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 543734004669 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 543734004670 protein binding site [polypeptide binding]; other site 543734004671 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 543734004672 putative substrate binding region [chemical binding]; other site 543734004673 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 543734004674 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 543734004675 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 543734004676 catalytic residue [active] 543734004677 putative FPP diphosphate binding site; other site 543734004678 putative FPP binding hydrophobic cleft; other site 543734004679 dimer interface [polypeptide binding]; other site 543734004680 putative IPP diphosphate binding site; other site 543734004681 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 543734004682 hinge region; other site 543734004683 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 543734004684 putative nucleotide binding site [chemical binding]; other site 543734004685 uridine monophosphate binding site [chemical binding]; other site 543734004686 homohexameric interface [polypeptide binding]; other site 543734004687 elongation factor Ts; Provisional; Region: tsf; PRK09377 543734004688 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 543734004689 Elongation factor TS; Region: EF_TS; pfam00889 543734004690 Elongation factor TS; Region: EF_TS; pfam00889 543734004691 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 543734004692 rRNA interaction site [nucleotide binding]; other site 543734004693 S8 interaction site; other site 543734004694 putative laminin-1 binding site; other site 543734004695 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 543734004696 GIY-YIG motif/motif A; other site 543734004697 putative active site [active] 543734004698 putative metal binding site [ion binding]; other site 543734004699 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 543734004700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734004701 S-adenosylmethionine binding site [chemical binding]; other site 543734004702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 543734004703 putative acyl-acceptor binding pocket; other site 543734004704 amino acid transporter; Region: 2A0306; TIGR00909 543734004705 Spore germination protein; Region: Spore_permease; cl15802 543734004706 Spore germination protein; Region: Spore_permease; cl15802 543734004707 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 543734004708 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734004709 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734004710 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 543734004711 Walker A/P-loop; other site 543734004712 ATP binding site [chemical binding]; other site 543734004713 Q-loop/lid; other site 543734004714 ABC transporter signature motif; other site 543734004715 Walker B; other site 543734004716 D-loop; other site 543734004717 H-loop/switch region; other site 543734004718 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734004719 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 543734004720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004721 Walker A/P-loop; other site 543734004722 ATP binding site [chemical binding]; other site 543734004723 Q-loop/lid; other site 543734004724 ABC transporter signature motif; other site 543734004725 Walker B; other site 543734004726 D-loop; other site 543734004727 H-loop/switch region; other site 543734004728 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 543734004729 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 543734004730 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 543734004731 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 543734004732 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 543734004733 RimM N-terminal domain; Region: RimM; pfam01782 543734004734 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 543734004735 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 543734004736 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 543734004737 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 543734004738 signal recognition particle protein; Provisional; Region: PRK10867 543734004739 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 543734004740 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 543734004741 P loop; other site 543734004742 GTP binding site [chemical binding]; other site 543734004743 Signal peptide binding domain; Region: SRP_SPB; pfam02978 543734004744 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 543734004745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734004746 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 543734004747 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 543734004748 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 543734004749 P loop; other site 543734004750 GTP binding site [chemical binding]; other site 543734004751 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 543734004752 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 543734004753 Walker A/P-loop; other site 543734004754 ATP binding site [chemical binding]; other site 543734004755 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 543734004756 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 543734004757 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 543734004758 ABC transporter signature motif; other site 543734004759 Walker B; other site 543734004760 D-loop; other site 543734004761 H-loop/switch region; other site 543734004762 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 543734004763 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 543734004764 dimerization interface [polypeptide binding]; other site 543734004765 active site 543734004766 metal binding site [ion binding]; metal-binding site 543734004767 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 543734004768 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 543734004769 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 543734004770 peptide binding site [polypeptide binding]; other site 543734004771 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 543734004772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 543734004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734004774 dimer interface [polypeptide binding]; other site 543734004775 conserved gate region; other site 543734004776 putative PBP binding loops; other site 543734004777 ABC-ATPase subunit interface; other site 543734004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734004779 ABC-ATPase subunit interface; other site 543734004780 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 543734004781 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 543734004782 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734004783 Walker A/P-loop; other site 543734004784 ATP binding site [chemical binding]; other site 543734004785 Q-loop/lid; other site 543734004786 ABC transporter signature motif; other site 543734004787 Walker B; other site 543734004788 D-loop; other site 543734004789 H-loop/switch region; other site 543734004790 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734004791 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 543734004792 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734004793 Walker A/P-loop; other site 543734004794 ATP binding site [chemical binding]; other site 543734004795 Q-loop/lid; other site 543734004796 ABC transporter signature motif; other site 543734004797 Walker B; other site 543734004798 D-loop; other site 543734004799 H-loop/switch region; other site 543734004800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734004801 Phosphopantetheine attachment site; Region: PP-binding; cl09936 543734004802 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 543734004803 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 543734004804 Y-family of DNA polymerases; Region: PolY; cl12025 543734004805 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 543734004806 generic binding surface II; other site 543734004807 ssDNA binding site; other site 543734004808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734004809 ATP binding site [chemical binding]; other site 543734004810 putative Mg++ binding site [ion binding]; other site 543734004811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734004812 nucleotide binding region [chemical binding]; other site 543734004813 ATP-binding site [chemical binding]; other site 543734004814 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 543734004815 DAK2 domain; Region: Dak2; cl03685 543734004816 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 543734004817 Asp23 family; Region: Asp23; cl00574 543734004818 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 543734004819 Thiamine pyrophosphokinase; Region: TPK; cd07995 543734004820 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 543734004821 active site 543734004822 dimerization interface [polypeptide binding]; other site 543734004823 thiamine binding site [chemical binding]; other site 543734004824 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 543734004825 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 543734004826 substrate binding site [chemical binding]; other site 543734004827 hexamer interface [polypeptide binding]; other site 543734004828 metal binding site [ion binding]; metal-binding site 543734004829 GTPase RsgA; Reviewed; Region: PRK00098 543734004830 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 543734004831 RNA binding site [nucleotide binding]; other site 543734004832 homodimer interface [polypeptide binding]; other site 543734004833 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 543734004834 GTPase/Zn-binding domain interface [polypeptide binding]; other site 543734004835 GTP/Mg2+ binding site [chemical binding]; other site 543734004836 G4 box; other site 543734004837 G5 box; other site 543734004838 G1 box; other site 543734004839 Switch I region; other site 543734004840 G2 box; other site 543734004841 G3 box; other site 543734004842 Switch II region; other site 543734004843 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 543734004844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 543734004845 active site 543734004846 ATP binding site [chemical binding]; other site 543734004847 substrate binding site [chemical binding]; other site 543734004848 activation loop (A-loop); other site 543734004849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 543734004850 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 543734004851 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 543734004852 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 543734004853 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 543734004854 active site 543734004855 16S rRNA methyltransferase B; Provisional; Region: PRK14902 543734004856 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 543734004857 putative RNA binding site [nucleotide binding]; other site 543734004858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734004859 S-adenosylmethionine binding site [chemical binding]; other site 543734004860 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 543734004861 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 543734004862 putative active site [active] 543734004863 substrate binding site [chemical binding]; other site 543734004864 putative cosubstrate binding site; other site 543734004865 catalytic site [active] 543734004866 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 543734004867 substrate binding site [chemical binding]; other site 543734004868 primosome assembly protein PriA; Validated; Region: PRK05580 543734004869 primosome assembly protein PriA; Validated; Region: PRK05580 543734004870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734004871 ATP binding site [chemical binding]; other site 543734004872 putative Mg++ binding site [ion binding]; other site 543734004873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734004874 nucleotide binding region [chemical binding]; other site 543734004875 ATP-binding site [chemical binding]; other site 543734004876 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 543734004877 Flavoprotein; Region: Flavoprotein; cl08021 543734004878 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 543734004879 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 543734004880 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 543734004881 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 543734004882 catalytic site [active] 543734004883 G-X2-G-X-G-K; other site 543734004884 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 543734004885 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 543734004886 nucleophile elbow; other site 543734004887 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 543734004888 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 543734004889 Walker A/P-loop; other site 543734004890 ATP binding site [chemical binding]; other site 543734004891 Q-loop/lid; other site 543734004892 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 543734004893 ABC transporter signature motif; other site 543734004894 Walker B; other site 543734004895 D-loop; other site 543734004896 H-loop/switch region; other site 543734004897 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 543734004898 arginine repressor; Provisional; Region: PRK04280 543734004899 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 543734004900 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 543734004901 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 543734004902 RNA binding surface [nucleotide binding]; other site 543734004903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 543734004904 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 543734004905 substrate binding pocket [chemical binding]; other site 543734004906 chain length determination region; other site 543734004907 substrate-Mg2+ binding site; other site 543734004908 catalytic residues [active] 543734004909 aspartate-rich region 1; other site 543734004910 active site lid residues [active] 543734004911 aspartate-rich region 2; other site 543734004912 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 543734004913 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 543734004914 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 543734004915 generic binding surface II; other site 543734004916 generic binding surface I; other site 543734004917 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 543734004918 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 543734004919 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 543734004920 homodimer interface [polypeptide binding]; other site 543734004921 NADP binding site [chemical binding]; other site 543734004922 substrate binding site [chemical binding]; other site 543734004923 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 543734004924 putative RNA binding site [nucleotide binding]; other site 543734004925 Asp23 family; Region: Asp23; cl00574 543734004926 elongation factor P; Validated; Region: PRK00529 543734004927 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 543734004928 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 543734004929 RNA binding site [nucleotide binding]; other site 543734004930 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 543734004931 RNA binding site [nucleotide binding]; other site 543734004932 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 543734004933 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 543734004934 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 543734004935 active site 543734004936 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 543734004937 Protein of unknown function (DUF464); Region: DUF464; cl01080 543734004938 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 543734004939 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 543734004940 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 543734004941 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 543734004942 glutamine synthetase, type I; Region: GlnA; TIGR00653 543734004943 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 543734004944 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 543734004945 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 543734004946 DNA binding residues [nucleotide binding] 543734004947 putative dimer interface [polypeptide binding]; other site 543734004948 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734004949 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 543734004950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 543734004951 catalytic residue [active] 543734004952 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 543734004953 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 543734004954 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734004955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 543734004956 catalytic residue [active] 543734004957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734004958 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 543734004959 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 543734004960 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 543734004961 active site residue [active] 543734004962 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 543734004963 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 543734004964 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 543734004965 Rhomboid family; Region: Rhomboid; cl11446 543734004966 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 543734004967 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 543734004968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734004969 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 543734004970 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734004971 Helix-turn-helix domains; Region: HTH; cl00088 543734004972 Helix-turn-helix domains; Region: HTH; cl00088 543734004973 Integrase core domain; Region: rve; cl01316 543734004974 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 543734004975 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 543734004976 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 543734004977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 543734004978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734004979 active site 543734004980 phosphorylation site [posttranslational modification] 543734004981 intermolecular recognition site; other site 543734004982 dimerization interface [polypeptide binding]; other site 543734004983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 543734004984 DNA binding residues [nucleotide binding] 543734004985 dimerization interface [polypeptide binding]; other site 543734004986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 543734004987 Histidine kinase; Region: HisKA_3; pfam07730 543734004988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734004989 ATP binding site [chemical binding]; other site 543734004990 Mg2+ binding site [ion binding]; other site 543734004991 G-X-G motif; other site 543734004992 Predicted membrane protein [Function unknown]; Region: COG4758 543734004993 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 543734004994 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 543734004995 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 543734004996 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 543734004997 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 543734004998 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 543734004999 ATP-binding site [chemical binding]; other site 543734005000 Sugar specificity; other site 543734005001 Pyrimidine base specificity; other site 543734005002 YceG-like family; Region: YceG; pfam02618 543734005003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 543734005004 dimerization interface [polypeptide binding]; other site 543734005005 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 543734005006 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 543734005007 putative tRNA-binding site [nucleotide binding]; other site 543734005008 B3/4 domain; Region: B3_4; cl11458 543734005009 tRNA synthetase B5 domain; Region: B5; cl08394 543734005010 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 543734005011 dimer interface [polypeptide binding]; other site 543734005012 motif 1; other site 543734005013 motif 3; other site 543734005014 motif 2; other site 543734005015 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 543734005016 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 543734005017 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 543734005018 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 543734005019 dimer interface [polypeptide binding]; other site 543734005020 motif 1; other site 543734005021 active site 543734005022 motif 2; other site 543734005023 motif 3; other site 543734005024 Helix-turn-helix domains; Region: HTH; cl00088 543734005025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734005026 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 543734005027 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 543734005028 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 543734005029 Acylphosphatase; Region: Acylphosphatase; cl00551 543734005030 OxaA-like protein precursor; Provisional; Region: PRK02463 543734005031 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 543734005032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 543734005033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734005034 dimer interface [polypeptide binding]; other site 543734005035 phosphorylation site [posttranslational modification] 543734005036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734005037 ATP binding site [chemical binding]; other site 543734005038 Mg2+ binding site [ion binding]; other site 543734005039 G-X-G motif; other site 543734005040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734005042 active site 543734005043 phosphorylation site [posttranslational modification] 543734005044 intermolecular recognition site; other site 543734005045 dimerization interface [polypeptide binding]; other site 543734005046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734005047 DNA binding site [nucleotide binding] 543734005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734005049 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 543734005050 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 543734005051 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 543734005052 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 543734005053 hypothetical protein; Provisional; Region: PRK13670 543734005054 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 543734005055 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 543734005056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734005057 S-adenosylmethionine binding site [chemical binding]; other site 543734005058 Oligomerisation domain; Region: Oligomerisation; cl00519 543734005059 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 543734005060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734005061 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 543734005062 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 543734005063 active site 543734005064 (T/H)XGH motif; other site 543734005065 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 543734005066 GTPase YqeH; Provisional; Region: PRK13796 543734005067 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 543734005068 GTP/Mg2+ binding site [chemical binding]; other site 543734005069 G4 box; other site 543734005070 G5 box; other site 543734005071 G1 box; other site 543734005072 Switch I region; other site 543734005073 G2 box; other site 543734005074 G3 box; other site 543734005075 Switch II region; other site 543734005076 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 543734005077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734005078 active site 543734005079 motif I; other site 543734005080 motif II; other site 543734005081 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 543734005082 Zn binding site [ion binding]; other site 543734005083 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 543734005084 Zn binding site [ion binding]; other site 543734005085 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 543734005086 Zn binding site [ion binding]; other site 543734005087 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 543734005088 Zn binding site [ion binding]; other site 543734005089 Predicted esterase [General function prediction only]; Region: COG0400 543734005090 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734005091 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 543734005092 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 543734005093 putative NAD(P) binding site [chemical binding]; other site 543734005094 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 543734005095 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 543734005096 23S rRNA binding site [nucleotide binding]; other site 543734005097 L21 binding site [polypeptide binding]; other site 543734005098 L13 binding site [polypeptide binding]; other site 543734005099 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 543734005100 translation initiation factor IF-3; Region: infC; TIGR00168 543734005101 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 543734005102 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 543734005103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734005104 catalytic core [active] 543734005105 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 543734005106 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 543734005107 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 543734005108 active site 543734005109 dimer interface [polypeptide binding]; other site 543734005110 motif 1; other site 543734005111 motif 2; other site 543734005112 motif 3; other site 543734005113 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 543734005114 anticodon binding site; other site 543734005115 primosomal protein DnaI; Reviewed; Region: PRK08939 543734005116 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 543734005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734005118 Walker A motif; other site 543734005119 ATP binding site [chemical binding]; other site 543734005120 Walker B motif; other site 543734005121 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 543734005122 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 543734005123 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 543734005124 ATP cone domain; Region: ATP-cone; pfam03477 543734005125 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 543734005126 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 543734005127 CoA-binding site [chemical binding]; other site 543734005128 ATP-binding [chemical binding]; other site 543734005129 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 543734005130 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 543734005131 DNA binding site [nucleotide binding] 543734005132 catalytic residue [active] 543734005133 H2TH interface [polypeptide binding]; other site 543734005134 putative catalytic residues [active] 543734005135 turnover-facilitating residue; other site 543734005136 intercalation triad [nucleotide binding]; other site 543734005137 8OG recognition residue [nucleotide binding]; other site 543734005138 putative reading head residues; other site 543734005139 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 543734005140 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 543734005141 DNA polymerase I; Provisional; Region: PRK05755 543734005142 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 543734005143 active site 543734005144 metal binding site 1 [ion binding]; metal-binding site 543734005145 putative 5' ssDNA interaction site; other site 543734005146 metal binding site 3; metal-binding site 543734005147 metal binding site 2 [ion binding]; metal-binding site 543734005148 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 543734005149 putative DNA binding site [nucleotide binding]; other site 543734005150 putative metal binding site [ion binding]; other site 543734005151 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 543734005152 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 543734005153 active site 543734005154 DNA binding site [nucleotide binding] 543734005155 catalytic site [active] 543734005156 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 543734005157 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 543734005158 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 543734005159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 543734005160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 543734005161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734005162 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 543734005163 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 543734005164 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 543734005165 putative tRNA-binding site [nucleotide binding]; other site 543734005166 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 543734005167 catalytic residues [active] 543734005168 Predicted small secreted protein [Function unknown]; Region: COG5584 543734005169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734005170 S-adenosylmethionine binding site [chemical binding]; other site 543734005171 potential protein location (hypothetical protein) that overlaps protein (tRNA (guanine-N(7)-)-methyltransferase) 543734005172 Phosphotransferase enzyme family; Region: APH; pfam01636 543734005173 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 543734005174 active site 543734005175 substrate binding site [chemical binding]; other site 543734005176 ATP binding site [chemical binding]; other site 543734005177 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 543734005178 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 543734005179 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734005180 Walker A/P-loop; other site 543734005181 ATP binding site [chemical binding]; other site 543734005182 Q-loop/lid; other site 543734005183 ABC transporter signature motif; other site 543734005184 Walker B; other site 543734005185 D-loop; other site 543734005186 H-loop/switch region; other site 543734005187 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 543734005188 HIT family signature motif; other site 543734005189 catalytic residue [active] 543734005190 YtxH-like protein; Region: YtxH; cl02079 543734005191 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 543734005192 SurA N-terminal domain; Region: SurA_N_3; cl07813 543734005193 PPIC-type PPIASE domain; Region: Rotamase; cl08278 543734005194 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 543734005195 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 543734005196 generic binding surface I; other site 543734005197 generic binding surface II; other site 543734005198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 543734005199 Zn2+ binding site [ion binding]; other site 543734005200 Mg2+ binding site [ion binding]; other site 543734005201 Protein of unknown function (DUF964); Region: DUF964; cl01483 543734005202 Transglycosylase; Region: Transgly; cl07896 543734005203 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 543734005204 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734005205 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 543734005206 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 543734005207 active site 543734005208 Arginine repressor [Transcription]; Region: ArgR; COG1438 543734005209 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 543734005210 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 543734005211 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 543734005212 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 543734005213 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 543734005214 active site 543734005215 HIGH motif; other site 543734005216 KMSK motif region; other site 543734005217 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 543734005218 tRNA binding surface [nucleotide binding]; other site 543734005219 anticodon binding site; other site 543734005220 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 543734005221 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 543734005222 active site 543734005223 FMN binding site [chemical binding]; other site 543734005224 substrate binding site [chemical binding]; other site 543734005225 catalytic residues [active] 543734005226 homodimer interface [polypeptide binding]; other site 543734005227 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 543734005228 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 543734005229 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 543734005230 putative active site [active] 543734005231 catalytic site [active] 543734005232 putative metal binding site [ion binding]; other site 543734005233 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 543734005234 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 543734005235 ArsC family; Region: ArsC; pfam03960 543734005236 putative catalytic residues [active] 543734005237 thiol/disulfide switch; other site 543734005238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734005239 FtsX-like permease family; Region: FtsX; cl15850 543734005240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734005241 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734005242 Walker A/P-loop; other site 543734005243 ATP binding site [chemical binding]; other site 543734005244 Q-loop/lid; other site 543734005245 ABC transporter signature motif; other site 543734005246 Walker B; other site 543734005247 D-loop; other site 543734005248 H-loop/switch region; other site 543734005249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734005250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734005251 active site 543734005252 phosphorylation site [posttranslational modification] 543734005253 intermolecular recognition site; other site 543734005254 dimerization interface [polypeptide binding]; other site 543734005255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734005256 DNA binding site [nucleotide binding] 543734005257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734005258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734005259 ATP binding site [chemical binding]; other site 543734005260 Mg2+ binding site [ion binding]; other site 543734005261 G-X-G motif; other site 543734005262 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 543734005263 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 543734005264 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 543734005265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734005266 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 543734005267 Helix-turn-helix domains; Region: HTH; cl00088 543734005268 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 543734005269 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 543734005270 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734005271 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 543734005272 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 543734005273 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 543734005274 purine monophosphate binding site [chemical binding]; other site 543734005275 dimer interface [polypeptide binding]; other site 543734005276 putative catalytic residues [active] 543734005277 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 543734005278 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 543734005279 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 543734005280 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 543734005281 active site 543734005282 substrate binding site [chemical binding]; other site 543734005283 cosubstrate binding site; other site 543734005284 catalytic site [active] 543734005285 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 543734005286 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 543734005287 dimerization interface [polypeptide binding]; other site 543734005288 putative ATP binding site [chemical binding]; other site 543734005289 amidophosphoribosyltransferase; Provisional; Region: PRK07272 543734005290 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 543734005291 active site 543734005292 tetramer interface [polypeptide binding]; other site 543734005293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734005294 active site 543734005295 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 543734005296 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 543734005297 dimerization interface [polypeptide binding]; other site 543734005298 ATP binding site [chemical binding]; other site 543734005299 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 543734005300 dimerization interface [polypeptide binding]; other site 543734005301 ATP binding site [chemical binding]; other site 543734005302 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 543734005303 putative active site [active] 543734005304 catalytic triad [active] 543734005305 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 543734005306 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 543734005307 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 543734005308 ATP binding site [chemical binding]; other site 543734005309 active site 543734005310 substrate binding site [chemical binding]; other site 543734005311 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 543734005312 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734005313 AIR carboxylase; Region: AIRC; cl00310 543734005314 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 543734005315 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 543734005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734005317 putative substrate translocation pore; other site 543734005318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734005319 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 543734005320 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 543734005321 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 543734005322 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 543734005323 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 543734005324 dimerization domain swap beta strand [polypeptide binding]; other site 543734005325 regulatory protein interface [polypeptide binding]; other site 543734005326 active site 543734005327 regulatory phosphorylation site [posttranslational modification]; other site 543734005328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734005329 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 543734005330 Walker A motif; other site 543734005331 ATP binding site [chemical binding]; other site 543734005332 Walker B motif; other site 543734005333 arginine finger; other site 543734005334 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 543734005335 UvrB/uvrC motif; Region: UVR; pfam02151 543734005336 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 543734005337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734005338 Walker A motif; other site 543734005339 ATP binding site [chemical binding]; other site 543734005340 Walker B motif; other site 543734005341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734005342 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 543734005343 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 543734005344 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 543734005345 G1 box; other site 543734005346 putative GEF interaction site [polypeptide binding]; other site 543734005347 GTP/Mg2+ binding site [chemical binding]; other site 543734005348 Switch I region; other site 543734005349 G2 box; other site 543734005350 G3 box; other site 543734005351 Switch II region; other site 543734005352 G4 box; other site 543734005353 G5 box; other site 543734005354 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 543734005355 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 543734005356 Domain of unknown function DUF21; Region: DUF21; pfam01595 543734005357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 543734005358 Transporter associated domain; Region: CorC_HlyC; cl08393 543734005359 Domain of unknown function DUF20; Region: UPF0118; pfam01594 543734005360 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 543734005361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734005362 Coenzyme A binding pocket [chemical binding]; other site 543734005363 Protein of unknown function (DUF402); Region: DUF402; cl00979 543734005364 RecX family; Region: RecX; cl00936 543734005365 Helix-turn-helix domains; Region: HTH; cl00088 543734005366 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 543734005367 TRAM domain; Region: TRAM; cl01282 543734005368 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 543734005369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 543734005370 TIR domain; Region: TIR_2; cl15770 543734005371 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734005372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734005373 DNA-binding site [nucleotide binding]; DNA binding site 543734005374 UTRA domain; Region: UTRA; cl01230 543734005375 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734005376 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 543734005377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734005378 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734005379 active site 543734005380 methionine cluster; other site 543734005381 phosphorylation site [posttranslational modification] 543734005382 metal binding site [ion binding]; metal-binding site 543734005383 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734005384 active site 543734005385 P-loop; other site 543734005386 phosphorylation site [posttranslational modification] 543734005387 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 543734005388 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 543734005389 PYR/PP interface [polypeptide binding]; other site 543734005390 tetramer interface [polypeptide binding]; other site 543734005391 dimer interface [polypeptide binding]; other site 543734005392 TPP binding site [chemical binding]; other site 543734005393 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 543734005394 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 543734005395 TPP-binding site [chemical binding]; other site 543734005396 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 543734005397 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 543734005398 dimer interface [polypeptide binding]; other site 543734005399 active site 543734005400 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 543734005401 homodimer interface [polypeptide binding]; other site 543734005402 NAD binding site [chemical binding]; other site 543734005403 catalytic residues [active] 543734005404 substrate binding pocket [chemical binding]; other site 543734005405 flexible flap; other site 543734005406 putative acyltransferase; Provisional; Region: PRK05790 543734005407 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 543734005408 dimer interface [polypeptide binding]; other site 543734005409 active site 543734005410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 543734005411 Restriction endonuclease; Region: Mrr_cat; cl00516 543734005412 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 543734005413 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 543734005414 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 543734005415 metal binding site [ion binding]; metal-binding site 543734005416 dimer interface [polypeptide binding]; other site 543734005417 Predicted membrane protein [Function unknown]; Region: COG4684 543734005418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 543734005419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734005420 Coenzyme A binding pocket [chemical binding]; other site 543734005421 hypothetical protein; Provisional; Region: PRK04351 543734005422 SprT homologues; Region: SprT; cl01182 543734005423 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 543734005424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734005425 Walker A/P-loop; other site 543734005426 ATP binding site [chemical binding]; other site 543734005427 Q-loop/lid; other site 543734005428 ABC transporter signature motif; other site 543734005429 Walker B; other site 543734005430 D-loop; other site 543734005431 H-loop/switch region; other site 543734005432 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 543734005433 TM-ABC transporter signature motif; other site 543734005434 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 543734005435 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 543734005436 zinc binding site [ion binding]; other site 543734005437 putative ligand binding site [chemical binding]; other site 543734005438 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734005439 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734005440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734005441 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734005442 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734005443 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734005444 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734005445 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 543734005446 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 543734005447 homodimer interface [polypeptide binding]; other site 543734005448 NAD binding pocket [chemical binding]; other site 543734005449 ATP binding pocket [chemical binding]; other site 543734005450 Mg binding site [ion binding]; other site 543734005451 active-site loop [active] 543734005452 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 543734005453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734005454 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 543734005455 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 543734005456 active site 543734005457 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734005458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734005459 DNA-binding site [nucleotide binding]; DNA binding site 543734005460 UTRA domain; Region: UTRA; cl01230 543734005461 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 543734005462 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 543734005463 active site 543734005464 dimer interface [polypeptide binding]; other site 543734005465 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 543734005466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734005467 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 543734005468 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734005469 potential protein location (hypothetical protein LCABL_20320 [lactobacillus casei BL23]) that overlaps RNA (tRNA-Y) 543734005470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 543734005471 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 543734005472 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 543734005473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734005474 putative substrate translocation pore; other site 543734005475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 543734005476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734005477 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734005478 Walker A/P-loop; other site 543734005479 ATP binding site [chemical binding]; other site 543734005480 Q-loop/lid; other site 543734005481 ABC transporter signature motif; other site 543734005482 Walker B; other site 543734005483 D-loop; other site 543734005484 H-loop/switch region; other site 543734005485 FtsX-like permease family; Region: FtsX; cl15850 543734005486 MFS/sugar transport protein; Region: MFS_2; pfam13347 543734005487 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 543734005488 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 543734005489 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 543734005490 catalytic residues [active] 543734005491 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 543734005492 active site 543734005493 nucleotide-binding site [chemical binding]; other site 543734005494 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 543734005495 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 543734005496 G1 box; other site 543734005497 GTP/Mg2+ binding site [chemical binding]; other site 543734005498 Switch I region; other site 543734005499 G2 box; other site 543734005500 G3 box; other site 543734005501 Switch II region; other site 543734005502 G4 box; other site 543734005503 G5 box; other site 543734005504 Nucleoside recognition; Region: Gate; cl00486 543734005505 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 543734005506 Nucleoside recognition; Region: Gate; cl00486 543734005507 FeoA domain; Region: FeoA; cl00838 543734005508 FeoA domain; Region: FeoA; cl00838 543734005509 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 543734005510 catalytic triad [active] 543734005511 catalytic triad [active] 543734005512 oxyanion hole [active] 543734005513 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 543734005514 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734005515 NAD binding site [chemical binding]; other site 543734005516 substrate binding site [chemical binding]; other site 543734005517 putative active site [active] 543734005518 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 543734005519 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 543734005520 seryl-tRNA synthetase; Provisional; Region: PRK05431 543734005521 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 543734005522 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 543734005523 dimer interface [polypeptide binding]; other site 543734005524 active site 543734005525 motif 1; other site 543734005526 motif 2; other site 543734005527 motif 3; other site 543734005528 Helix-turn-helix domains; Region: HTH; cl00088 543734005529 Helix-turn-helix domains; Region: HTH; cl00088 543734005530 lysine transporter; Provisional; Region: PRK10836 543734005531 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 543734005532 acetolactate synthase; Reviewed; Region: PRK08617 543734005533 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 543734005534 PYR/PP interface [polypeptide binding]; other site 543734005535 dimer interface [polypeptide binding]; other site 543734005536 TPP binding site [chemical binding]; other site 543734005537 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 543734005538 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 543734005539 TPP-binding site [chemical binding]; other site 543734005540 dimer interface [polypeptide binding]; other site 543734005541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 543734005542 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734005543 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734005544 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734005545 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 543734005546 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 543734005547 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 543734005548 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 543734005549 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 543734005550 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 543734005551 active site 543734005552 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 543734005553 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734005554 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 543734005555 potential protein location (hypothetical protein) that overlaps protein (Triphosphoribosyl-dephospho-coenzymeA synthase) 543734005556 Transcriptional regulators [Transcription]; Region: GntR; COG1802 543734005557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734005558 DNA-binding site [nucleotide binding]; DNA binding site 543734005559 FCD domain; Region: FCD; cl11656 543734005560 oxaloacetate decarboxylase; Provisional; Region: PRK12331 543734005561 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 543734005562 active site 543734005563 catalytic residues [active] 543734005564 metal binding site [ion binding]; metal-binding site 543734005565 homodimer binding site [polypeptide binding]; other site 543734005566 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 543734005567 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 543734005568 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734005569 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734005570 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 543734005571 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 543734005572 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 543734005573 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 543734005574 active site 543734005575 nucleotide binding site [chemical binding]; other site 543734005576 HIGH motif; other site 543734005577 KMSKS motif; other site 543734005578 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 543734005579 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 543734005580 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 543734005581 carboxyltransferase (CT) interaction site; other site 543734005582 biotinylation site [posttranslational modification]; other site 543734005583 Citrate transporter; Region: CitMHS; pfam03600 543734005584 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734005585 transmembrane helices; other site 543734005586 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 543734005587 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 543734005588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734005589 Coenzyme A binding pocket [chemical binding]; other site 543734005590 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 543734005591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734005592 Helix-turn-helix domains; Region: HTH; cl00088 543734005593 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 543734005594 dimer interface [polypeptide binding]; other site 543734005595 FMN binding site [chemical binding]; other site 543734005596 NADPH bind site [chemical binding]; other site 543734005597 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734005598 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734005599 Walker A/P-loop; other site 543734005600 ATP binding site [chemical binding]; other site 543734005601 Q-loop/lid; other site 543734005602 ABC transporter signature motif; other site 543734005603 Walker B; other site 543734005604 D-loop; other site 543734005605 H-loop/switch region; other site 543734005606 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734005607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734005608 Helix-turn-helix domains; Region: HTH; cl00088 543734005609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734005610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734005611 putative substrate translocation pore; other site 543734005612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734005613 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 543734005614 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 543734005615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734005616 non-specific DNA binding site [nucleotide binding]; other site 543734005617 salt bridge; other site 543734005618 sequence-specific DNA binding site [nucleotide binding]; other site 543734005619 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734005620 Predicted transcriptional regulators [Transcription]; Region: COG1725 543734005621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734005622 DNA-binding site [nucleotide binding]; DNA binding site 543734005623 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 543734005624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734005625 Walker A/P-loop; other site 543734005626 ATP binding site [chemical binding]; other site 543734005627 Q-loop/lid; other site 543734005628 ABC transporter signature motif; other site 543734005629 Walker B; other site 543734005630 D-loop; other site 543734005631 H-loop/switch region; other site 543734005632 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 543734005633 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734005634 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 543734005635 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734005636 Walker A/P-loop; other site 543734005637 ATP binding site [chemical binding]; other site 543734005638 Q-loop/lid; other site 543734005639 ABC transporter signature motif; other site 543734005640 Walker B; other site 543734005641 D-loop; other site 543734005642 H-loop/switch region; other site 543734005643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734005644 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 543734005645 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734005646 Walker A/P-loop; other site 543734005647 ATP binding site [chemical binding]; other site 543734005648 Q-loop/lid; other site 543734005649 ABC transporter signature motif; other site 543734005650 Walker B; other site 543734005651 D-loop; other site 543734005652 H-loop/switch region; other site 543734005653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734005654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 543734005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734005656 dimer interface [polypeptide binding]; other site 543734005657 conserved gate region; other site 543734005658 putative PBP binding loops; other site 543734005659 ABC-ATPase subunit interface; other site 543734005660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 543734005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734005662 dimer interface [polypeptide binding]; other site 543734005663 conserved gate region; other site 543734005664 putative PBP binding loops; other site 543734005665 ABC-ATPase subunit interface; other site 543734005666 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734005667 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734005668 peptide binding site [polypeptide binding]; other site 543734005669 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 543734005670 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 543734005671 potential catalytic triad [active] 543734005672 conserved cys residue [active] 543734005673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734005674 putative DNA binding site [nucleotide binding]; other site 543734005675 dimerization interface [polypeptide binding]; other site 543734005676 putative Zn2+ binding site [ion binding]; other site 543734005677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734005678 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734005679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734005680 Walker A/P-loop; other site 543734005681 ATP binding site [chemical binding]; other site 543734005682 Q-loop/lid; other site 543734005683 ABC transporter signature motif; other site 543734005684 Walker B; other site 543734005685 D-loop; other site 543734005686 H-loop/switch region; other site 543734005687 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734005688 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734005689 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 543734005690 Walker A/P-loop; other site 543734005691 ATP binding site [chemical binding]; other site 543734005692 Q-loop/lid; other site 543734005693 ABC transporter signature motif; other site 543734005694 Walker B; other site 543734005695 D-loop; other site 543734005696 H-loop/switch region; other site 543734005697 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 543734005698 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 543734005699 putative peptidoglycan binding site; other site 543734005700 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 543734005701 active site 543734005702 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734005703 Helix-turn-helix domains; Region: HTH; cl00088 543734005704 Integrase core domain; Region: rve; cl01316 543734005705 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734005706 Helix-turn-helix domains; Region: HTH; cl00088 543734005707 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734005708 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 543734005709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734005710 non-specific DNA binding site [nucleotide binding]; other site 543734005711 salt bridge; other site 543734005712 sequence-specific DNA binding site [nucleotide binding]; other site 543734005713 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 543734005714 Helix-turn-helix domains; Region: HTH; cl00088 543734005715 Transposase; Region: DDE_Tnp_ISL3; pfam01610 543734005716 Transposase; Region: DDE_Tnp_ISL3; pfam01610 543734005717 Integrase core domain; Region: rve; cl01316 543734005718 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 543734005719 Transposase domain (DUF772); Region: DUF772; cl15789 543734005720 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734005721 Helix-turn-helix domains; Region: HTH; cl00088 543734005722 Integrase core domain; Region: rve; cl01316 543734005723 Helix-turn-helix domains; Region: HTH; cl00088 543734005724 HTH-like domain; Region: HTH_21; pfam13276 543734005725 Integrase core domain; Region: rve; cl01316 543734005726 Integrase core domain; Region: rve_3; cl15866 543734005727 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 543734005728 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 543734005729 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734005730 Helix-turn-helix domains; Region: HTH; cl00088 543734005731 Integrase core domain; Region: rve; cl01316 543734005732 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 543734005733 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734005734 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 543734005735 SxDxEG motif; other site 543734005736 putative active site [active] 543734005737 putative metal binding site [ion binding]; other site 543734005738 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 543734005739 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 543734005740 oligomer interface [polypeptide binding]; other site 543734005741 active site 543734005742 metal binding site [ion binding]; metal-binding site 543734005743 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734005744 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734005745 peptide binding site [polypeptide binding]; other site 543734005746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 543734005747 Integrase core domain; Region: rve; cl01316 543734005748 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 543734005749 Helix-turn-helix domain; Region: HTH_16; pfam12645 543734005750 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 543734005751 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 543734005752 nucleic acid-binding interface [nucleotide binding]; other site 543734005753 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734005754 Int/Topo IB signature motif; other site 543734005755 GMP synthase; Reviewed; Region: guaA; PRK00074 543734005756 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 543734005757 AMP/PPi binding site [chemical binding]; other site 543734005758 candidate oxyanion hole; other site 543734005759 catalytic triad [active] 543734005760 potential glutamine specificity residues [chemical binding]; other site 543734005761 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 543734005762 ATP Binding subdomain [chemical binding]; other site 543734005763 Dimerization subdomain; other site 543734005764 pantothenate kinase; Provisional; Region: PRK05439 543734005765 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 543734005766 ATP-binding site [chemical binding]; other site 543734005767 CoA-binding site [chemical binding]; other site 543734005768 Mg2+-binding site [ion binding]; other site 543734005769 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 543734005770 Peptidase family C69; Region: Peptidase_C69; pfam03577 543734005771 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 543734005772 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 543734005773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734005774 Family description; Region: UvrD_C_2; cl15862 543734005775 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 543734005776 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 543734005777 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 543734005778 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734005779 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 543734005780 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 543734005781 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 543734005782 Ferrochelatase; Region: Ferrochelatase; pfam00762 543734005783 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 543734005784 C-terminal domain interface [polypeptide binding]; other site 543734005785 active site 543734005786 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 543734005787 active site 543734005788 N-terminal domain interface [polypeptide binding]; other site 543734005789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734005790 catalytic core [active] 543734005791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734005792 FtsX-like permease family; Region: FtsX; cl15850 543734005793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734005794 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734005795 Walker A/P-loop; other site 543734005796 ATP binding site [chemical binding]; other site 543734005797 Q-loop/lid; other site 543734005798 ABC transporter signature motif; other site 543734005799 Walker B; other site 543734005800 D-loop; other site 543734005801 H-loop/switch region; other site 543734005802 Amino acid permease; Region: AA_permease_2; pfam13520 543734005803 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 543734005804 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 543734005805 hypothetical protein 543734005806 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 543734005807 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 543734005808 HflX GTPase family; Region: HflX; cd01878 543734005809 G1 box; other site 543734005810 GTP/Mg2+ binding site [chemical binding]; other site 543734005811 Switch I region; other site 543734005812 G2 box; other site 543734005813 G3 box; other site 543734005814 Switch II region; other site 543734005815 G4 box; other site 543734005816 G5 box; other site 543734005817 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 543734005818 NodB motif; other site 543734005819 active site 543734005820 catalytic site [active] 543734005821 Zn binding site [ion binding]; other site 543734005822 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 543734005823 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 543734005824 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 543734005825 putative active site [active] 543734005826 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 543734005827 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 543734005828 NADP binding site [chemical binding]; other site 543734005829 active site 543734005830 putative substrate binding site [chemical binding]; other site 543734005831 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 543734005832 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 543734005833 NAD binding site [chemical binding]; other site 543734005834 substrate binding site [chemical binding]; other site 543734005835 homodimer interface [polypeptide binding]; other site 543734005836 active site 543734005837 Cupin domain; Region: Cupin_2; cl09118 543734005838 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 543734005839 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 543734005840 substrate binding site; other site 543734005841 tetramer interface; other site 543734005842 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 543734005843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734005844 Bacterial sugar transferase; Region: Bac_transf; cl00939 543734005845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734005846 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 543734005847 NAD(P) binding site [chemical binding]; other site 543734005848 active site 543734005849 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734005850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734005851 dimer interface [polypeptide binding]; other site 543734005852 conserved gate region; other site 543734005853 putative PBP binding loops; other site 543734005854 ABC-ATPase subunit interface; other site 543734005855 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734005856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734005857 dimer interface [polypeptide binding]; other site 543734005858 conserved gate region; other site 543734005859 putative PBP binding loops; other site 543734005860 ABC-ATPase subunit interface; other site 543734005861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734005862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734005863 substrate binding pocket [chemical binding]; other site 543734005864 membrane-bound complex binding site; other site 543734005865 hinge residues; other site 543734005866 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 543734005867 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 543734005868 Walker A/P-loop; other site 543734005869 ATP binding site [chemical binding]; other site 543734005870 Q-loop/lid; other site 543734005871 ABC transporter signature motif; other site 543734005872 Walker B; other site 543734005873 D-loop; other site 543734005874 H-loop/switch region; other site 543734005875 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 543734005876 metal binding site 2 [ion binding]; metal-binding site 543734005877 putative DNA binding helix; other site 543734005878 metal binding site 1 [ion binding]; metal-binding site 543734005879 dimer interface [polypeptide binding]; other site 543734005880 structural Zn2+ binding site [ion binding]; other site 543734005881 Guanylate kinase; Region: Guanylate_kin; pfam00625 543734005882 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 543734005883 catalytic site [active] 543734005884 G-X2-G-X-G-K; other site 543734005885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 543734005886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734005887 Coenzyme A binding pocket [chemical binding]; other site 543734005888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 543734005889 NlpC/P60 family; Region: NLPC_P60; cl11438 543734005890 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 543734005891 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 543734005892 active site 543734005893 HIGH motif; other site 543734005894 dimer interface [polypeptide binding]; other site 543734005895 KMSKS motif; other site 543734005896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 543734005897 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 543734005898 Cation efflux family; Region: Cation_efflux; cl00316 543734005899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734005900 dimerization interface [polypeptide binding]; other site 543734005901 putative DNA binding site [nucleotide binding]; other site 543734005902 putative Zn2+ binding site [ion binding]; other site 543734005903 ApbE family; Region: ApbE; cl00643 543734005904 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 543734005905 active site 543734005906 homodimer interface [polypeptide binding]; other site 543734005907 catalytic site [active] 543734005908 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 543734005909 homodimer interface [polypeptide binding]; other site 543734005910 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 543734005911 active site pocket [active] 543734005912 glycogen synthase; Provisional; Region: glgA; PRK00654 543734005913 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 543734005914 ADP-binding pocket [chemical binding]; other site 543734005915 homodimer interface [polypeptide binding]; other site 543734005916 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 543734005917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 543734005918 active site 543734005919 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 543734005920 dimer interface [polypeptide binding]; other site 543734005921 N-terminal domain interface [polypeptide binding]; other site 543734005922 sulfate 1 binding site; other site 543734005923 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 543734005924 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 543734005925 ligand binding site; other site 543734005926 oligomer interface; other site 543734005927 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 543734005928 dimer interface [polypeptide binding]; other site 543734005929 N-terminal domain interface [polypeptide binding]; other site 543734005930 sulfate 1 binding site; other site 543734005931 glycogen branching enzyme; Provisional; Region: PRK12313 543734005932 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 543734005933 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 543734005934 active site 543734005935 catalytic site [active] 543734005936 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 543734005937 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 543734005938 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 543734005939 homodimer interface [polypeptide binding]; other site 543734005940 substrate-cofactor binding pocket; other site 543734005941 catalytic residue [active] 543734005942 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 543734005943 Uncharacterized conserved protein [Function unknown]; Region: COG1284 543734005944 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 543734005945 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 543734005946 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 543734005947 ArsC family; Region: ArsC; pfam03960 543734005948 putative catalytic residues [active] 543734005949 thiol/disulfide switch; other site 543734005950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734005951 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 543734005952 Walker A motif; other site 543734005953 ATP binding site [chemical binding]; other site 543734005954 Walker B motif; other site 543734005955 arginine finger; other site 543734005956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734005957 Walker A motif; other site 543734005958 ATP binding site [chemical binding]; other site 543734005959 Walker B motif; other site 543734005960 arginine finger; other site 543734005961 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734005962 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 543734005963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 543734005964 active site 543734005965 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 543734005966 Transposase; Region: DDE_Tnp_ISL3; pfam01610 543734005967 Transposase domain (DUF772); Region: DUF772; cl15789 543734005968 Transposase domain (DUF772); Region: DUF772; cl15789 543734005969 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 543734005970 Helix-turn-helix domains; Region: HTH; cl00088 543734005971 Transposase; Region: DDE_Tnp_ISL3; pfam01610 543734005972 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 543734005973 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 543734005974 NADP binding site [chemical binding]; other site 543734005975 active site 543734005976 putative substrate binding site [chemical binding]; other site 543734005977 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 543734005978 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 543734005979 NAD binding site [chemical binding]; other site 543734005980 substrate binding site [chemical binding]; other site 543734005981 homodimer interface [polypeptide binding]; other site 543734005982 active site 543734005983 Cupin domain; Region: Cupin_2; cl09118 543734005984 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 543734005985 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 543734005986 substrate binding site; other site 543734005987 tetramer interface; other site 543734005988 Bacterial sugar transferase; Region: Bac_transf; cl00939 543734005989 Transposase domain (DUF772); Region: DUF772; cl15789 543734005990 Transposase domain (DUF772); Region: DUF772; cl15789 543734005991 Bacterial sugar transferase; Region: Bac_transf; cl00939 543734005992 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 543734005993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 543734005994 active site 543734005995 MatE; Region: MatE; cl10513 543734005996 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 543734005997 trimer interface [polypeptide binding]; other site 543734005998 active site 543734005999 substrate binding site [chemical binding]; other site 543734006000 CoA binding site [chemical binding]; other site 543734006001 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 543734006002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 543734006003 active site 543734006004 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 543734006005 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 543734006006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 543734006007 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 543734006008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006009 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 543734006010 Chain length determinant protein; Region: Wzz; cl15801 543734006011 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 543734006012 catalytic triad [active] 543734006013 catalytic triad [active] 543734006014 oxyanion hole [active] 543734006015 QueT transporter; Region: QueT; cl01932 543734006016 aldose dehydrogenase; Validated; Region: PRK06398 543734006017 classical (c) SDRs; Region: SDR_c; cd05233 543734006018 NAD(P) binding site [chemical binding]; other site 543734006019 active site 543734006020 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 543734006021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734006022 non-specific DNA binding site [nucleotide binding]; other site 543734006023 salt bridge; other site 543734006024 sequence-specific DNA binding site [nucleotide binding]; other site 543734006025 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734006026 catalytic core [active] 543734006027 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 543734006028 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734006029 Walker A/P-loop; other site 543734006030 ATP binding site [chemical binding]; other site 543734006031 Q-loop/lid; other site 543734006032 ABC transporter signature motif; other site 543734006033 Walker B; other site 543734006034 D-loop; other site 543734006035 H-loop/switch region; other site 543734006036 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734006037 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 543734006038 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 543734006039 Walker A/P-loop; other site 543734006040 ATP binding site [chemical binding]; other site 543734006041 Q-loop/lid; other site 543734006042 ABC transporter signature motif; other site 543734006043 Walker B; other site 543734006044 D-loop; other site 543734006045 H-loop/switch region; other site 543734006046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 543734006047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 543734006048 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 543734006049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734006050 dimer interface [polypeptide binding]; other site 543734006051 conserved gate region; other site 543734006052 putative PBP binding loops; other site 543734006053 ABC-ATPase subunit interface; other site 543734006054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 543734006055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734006056 dimer interface [polypeptide binding]; other site 543734006057 conserved gate region; other site 543734006058 putative PBP binding loops; other site 543734006059 ABC-ATPase subunit interface; other site 543734006060 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734006061 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734006062 peptide binding site [polypeptide binding]; other site 543734006063 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734006064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006065 putative substrate translocation pore; other site 543734006066 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734006067 Helix-turn-helix domains; Region: HTH; cl00088 543734006068 Helix-turn-helix domains; Region: HTH; cl00088 543734006069 Integrase core domain; Region: rve; cl01316 543734006070 elongation factor P; Validated; Region: PRK00529 543734006071 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 543734006072 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 543734006073 RNA binding site [nucleotide binding]; other site 543734006074 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 543734006075 RNA binding site [nucleotide binding]; other site 543734006076 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 543734006077 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 543734006078 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 543734006079 Cysteine-rich domain; Region: CCG; pfam02754 543734006080 Cysteine-rich domain; Region: CCG; pfam02754 543734006081 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734006082 active site 543734006083 methionine cluster; other site 543734006084 phosphorylation site [posttranslational modification] 543734006085 metal binding site [ion binding]; metal-binding site 543734006086 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 543734006087 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 543734006088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734006089 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 543734006090 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 543734006091 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 543734006092 Protein of unknown function (DUF328); Region: DUF328; cl01143 543734006093 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 543734006094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 543734006095 DNA binding residues [nucleotide binding] 543734006096 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 543734006097 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 543734006098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006099 Family description; Region: UvrD_C_2; cl15862 543734006100 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734006101 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 543734006102 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 543734006103 substrate binding site [chemical binding]; other site 543734006104 ATP binding site [chemical binding]; other site 543734006105 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 543734006106 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 543734006107 Uncharacterized conserved protein [Function unknown]; Region: COG3535 543734006108 Protein of unknown function (DUF917); Region: DUF917; pfam06032 543734006109 Sodium:solute symporter family; Region: SSF; cl00456 543734006110 Protein of unknown function DUF262; Region: DUF262; cl14890 543734006111 Protein of unknown function DUF262; Region: DUF262; cl14890 543734006112 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 543734006113 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734006114 Int/Topo IB signature motif; other site 543734006115 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 543734006116 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 543734006117 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 543734006118 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 543734006119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006120 HsdM N-terminal domain; Region: HsdM_N; pfam12161 543734006121 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 543734006122 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 543734006123 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 543734006124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734006125 ATP binding site [chemical binding]; other site 543734006126 putative Mg++ binding site [ion binding]; other site 543734006127 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 543734006128 Protein of unknown function (DUF998); Region: DUF998; pfam06197 543734006129 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 543734006130 HPr interaction site; other site 543734006131 glycerol kinase (GK) interaction site [polypeptide binding]; other site 543734006132 active site 543734006133 phosphorylation site [posttranslational modification] 543734006134 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 543734006135 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 543734006136 active site turn [active] 543734006137 phosphorylation site [posttranslational modification] 543734006138 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734006139 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734006140 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734006141 Ca binding site [ion binding]; other site 543734006142 active site 543734006143 catalytic site [active] 543734006144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734006145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734006146 DNA binding site [nucleotide binding] 543734006147 domain linker motif; other site 543734006148 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 543734006149 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 543734006150 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 543734006151 substrate binding [chemical binding]; other site 543734006152 active site 543734006153 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 543734006154 hypothetical protein 543734006155 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 543734006156 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 543734006157 NADP binding site [chemical binding]; other site 543734006158 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 543734006159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734006160 S-adenosylmethionine binding site [chemical binding]; other site 543734006161 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 543734006162 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 543734006163 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 543734006164 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 543734006165 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 543734006166 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734006167 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 543734006168 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 543734006169 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 543734006170 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 543734006171 carboxyltransferase (CT) interaction site; other site 543734006172 biotinylation site [posttranslational modification]; other site 543734006173 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 543734006174 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 543734006175 dimer interface [polypeptide binding]; other site 543734006176 active site 543734006177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 543734006178 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 543734006179 NAD(P) binding site [chemical binding]; other site 543734006180 homotetramer interface [polypeptide binding]; other site 543734006181 homodimer interface [polypeptide binding]; other site 543734006182 active site 543734006183 Acyl transferase domain; Region: Acyl_transf_1; cl08282 543734006184 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 543734006185 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 543734006186 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 543734006187 FMN binding site [chemical binding]; other site 543734006188 substrate binding site [chemical binding]; other site 543734006189 putative catalytic residue [active] 543734006190 Phosphopantetheine attachment site; Region: PP-binding; cl09936 543734006191 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 543734006192 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 543734006193 dimer interface [polypeptide binding]; other site 543734006194 active site 543734006195 CoA binding pocket [chemical binding]; other site 543734006196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 543734006197 Helix-turn-helix domains; Region: HTH; cl00088 543734006198 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 543734006199 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 543734006200 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 543734006201 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 543734006202 dimer interface [polypeptide binding]; other site 543734006203 active site 543734006204 metal binding site [ion binding]; metal-binding site 543734006205 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734006206 Helix-turn-helix domains; Region: HTH; cl00088 543734006207 Helix-turn-helix domains; Region: HTH; cl00088 543734006208 Integrase core domain; Region: rve; cl01316 543734006209 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 543734006210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 543734006211 Helix-turn-helix domains; Region: HTH; cl00088 543734006212 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 543734006213 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734006214 Predicted esterase [General function prediction only]; Region: COG0627 543734006215 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 543734006216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 543734006217 Helix-turn-helix domains; Region: HTH; cl00088 543734006218 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734006219 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006221 Walker A/P-loop; other site 543734006222 ATP binding site [chemical binding]; other site 543734006223 Q-loop/lid; other site 543734006224 ABC transporter signature motif; other site 543734006225 Walker B; other site 543734006226 D-loop; other site 543734006227 H-loop/switch region; other site 543734006228 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 543734006229 nudix motif; other site 543734006230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734006231 catalytic core [active] 543734006232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734006233 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 543734006234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734006235 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 543734006236 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 543734006237 active site 543734006238 catalytic site [active] 543734006239 GtrA-like protein; Region: GtrA; cl00971 543734006240 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 543734006241 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 543734006242 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 543734006243 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 543734006244 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 543734006245 PYR/PP interface [polypeptide binding]; other site 543734006246 dimer interface [polypeptide binding]; other site 543734006247 TPP binding site [chemical binding]; other site 543734006248 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 543734006249 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 543734006250 TPP-binding site [chemical binding]; other site 543734006251 hypothetical protein 543734006252 NMT1-like family; Region: NMT1_2; cl15260 543734006253 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 543734006254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734006255 dimer interface [polypeptide binding]; other site 543734006256 conserved gate region; other site 543734006257 putative PBP binding loops; other site 543734006258 ABC-ATPase subunit interface; other site 543734006259 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 543734006260 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 543734006261 Walker A/P-loop; other site 543734006262 ATP binding site [chemical binding]; other site 543734006263 Q-loop/lid; other site 543734006264 ABC transporter signature motif; other site 543734006265 Walker B; other site 543734006266 D-loop; other site 543734006267 H-loop/switch region; other site 543734006268 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 543734006269 Sugar fermentation stimulation protein; Region: SfsA; cl00647 543734006270 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 543734006271 Ligand Binding Site [chemical binding]; other site 543734006272 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 543734006273 ATP-grasp domain; Region: ATP-grasp_4; cl03087 543734006274 homoserine kinase; Provisional; Region: PRK01212 543734006275 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 543734006276 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 543734006277 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 543734006278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734006279 catalytic residue [active] 543734006280 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 543734006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006282 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 543734006283 aspartate kinase; Reviewed; Region: PRK09034 543734006284 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 543734006285 nucleotide binding site [chemical binding]; other site 543734006286 substrate binding site [chemical binding]; other site 543734006287 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 543734006288 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 543734006289 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 543734006290 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734006291 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 543734006292 D-lactate dehydrogenase; Validated; Region: PRK08605 543734006293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006294 aromatic amino acid aminotransferase; Validated; Region: PRK07309 543734006295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734006296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734006297 homodimer interface [polypeptide binding]; other site 543734006298 catalytic residue [active] 543734006299 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 543734006300 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 543734006301 nucleotide binding site/active site [active] 543734006302 HIT family signature motif; other site 543734006303 catalytic residue [active] 543734006304 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 543734006305 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 543734006306 active site 543734006307 dimer interface [polypeptide binding]; other site 543734006308 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 543734006309 Ligand Binding Site [chemical binding]; other site 543734006310 Molecular Tunnel; other site 543734006311 Predicted integral membrane protein [Function unknown]; Region: COG0392 543734006312 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 543734006313 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 543734006314 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 543734006315 active site 543734006316 metal binding site [ion binding]; metal-binding site 543734006317 UbiA prenyltransferase family; Region: UbiA; cl00337 543734006318 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 543734006319 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 543734006320 substrate binding pocket [chemical binding]; other site 543734006321 chain length determination region; other site 543734006322 substrate-Mg2+ binding site; other site 543734006323 catalytic residues [active] 543734006324 aspartate-rich region 1; other site 543734006325 active site lid residues [active] 543734006326 aspartate-rich region 2; other site 543734006327 Acetokinase family; Region: Acetate_kinase; cl01029 543734006328 propionate/acetate kinase; Provisional; Region: PRK12379 543734006329 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 543734006330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006331 Walker A/P-loop; other site 543734006332 ATP binding site [chemical binding]; other site 543734006333 Q-loop/lid; other site 543734006334 ABC transporter signature motif; other site 543734006335 Walker B; other site 543734006336 D-loop; other site 543734006337 H-loop/switch region; other site 543734006338 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 543734006339 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 543734006340 Predicted transcriptional regulators [Transcription]; Region: COG1725 543734006341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734006342 DNA-binding site [nucleotide binding]; DNA binding site 543734006343 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 543734006344 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734006345 Walker A/P-loop; other site 543734006346 ATP binding site [chemical binding]; other site 543734006347 Q-loop/lid; other site 543734006348 ABC transporter signature motif; other site 543734006349 Walker B; other site 543734006350 D-loop; other site 543734006351 H-loop/switch region; other site 543734006352 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 543734006353 glucose-1-dehydrogenase; Provisional; Region: PRK08936 543734006354 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 543734006355 NAD binding site [chemical binding]; other site 543734006356 homodimer interface [polypeptide binding]; other site 543734006357 active site 543734006358 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 543734006359 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 543734006360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006361 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 543734006362 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 543734006363 tetramer interface [polypeptide binding]; other site 543734006364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734006365 catalytic residue [active] 543734006366 OPT oligopeptide transporter protein; Region: OPT; cl14607 543734006367 OPT oligopeptide transporter protein; Region: OPT; cl14607 543734006368 OPT oligopeptide transporter protein; Region: OPT; cl14607 543734006369 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 543734006370 Peptidase family C69; Region: Peptidase_C69; pfam03577 543734006371 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 543734006372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734006373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734006374 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734006375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006376 putative substrate translocation pore; other site 543734006377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734006378 Helix-turn-helix domains; Region: HTH; cl00088 543734006379 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734006380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 543734006381 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 543734006382 active site turn [active] 543734006383 phosphorylation site [posttranslational modification] 543734006384 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734006385 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 543734006386 HPr interaction site; other site 543734006387 glycerol kinase (GK) interaction site [polypeptide binding]; other site 543734006388 active site 543734006389 phosphorylation site [posttranslational modification] 543734006390 transcriptional antiterminator BglG; Provisional; Region: PRK09772 543734006391 CAT RNA binding domain; Region: CAT_RBD; cl03904 543734006392 PRD domain; Region: PRD; cl15445 543734006393 PRD domain; Region: PRD; cl15445 543734006394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734006395 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006396 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 543734006397 Walker A/P-loop; other site 543734006398 ATP binding site [chemical binding]; other site 543734006399 Q-loop/lid; other site 543734006400 ABC transporter signature motif; other site 543734006401 Walker B; other site 543734006402 D-loop; other site 543734006403 H-loop/switch region; other site 543734006404 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006405 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 543734006406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006407 Walker A/P-loop; other site 543734006408 ATP binding site [chemical binding]; other site 543734006409 Q-loop/lid; other site 543734006410 ABC transporter signature motif; other site 543734006411 Walker B; other site 543734006412 D-loop; other site 543734006413 H-loop/switch region; other site 543734006414 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 543734006415 trimer interface [polypeptide binding]; other site 543734006416 Helix-turn-helix domains; Region: HTH; cl00088 543734006417 putative transposase OrfB; Reviewed; Region: PHA02517 543734006418 HTH-like domain; Region: HTH_21; pfam13276 543734006419 Integrase core domain; Region: rve; cl01316 543734006420 Integrase core domain; Region: rve_3; cl15866 543734006421 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 543734006422 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cl09913 543734006423 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 543734006424 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 543734006425 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 543734006426 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 543734006427 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 543734006428 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 543734006429 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006430 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 543734006431 Walker A/P-loop; other site 543734006432 ATP binding site [chemical binding]; other site 543734006433 Q-loop/lid; other site 543734006434 ABC transporter signature motif; other site 543734006435 Walker B; other site 543734006436 D-loop; other site 543734006437 H-loop/switch region; other site 543734006438 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 543734006439 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006441 Walker A/P-loop; other site 543734006442 ATP binding site [chemical binding]; other site 543734006443 Q-loop/lid; other site 543734006444 ABC transporter signature motif; other site 543734006445 Walker B; other site 543734006446 D-loop; other site 543734006447 H-loop/switch region; other site 543734006448 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 543734006449 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 543734006450 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 543734006451 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 543734006452 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 543734006453 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 543734006454 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 543734006455 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 543734006456 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 543734006457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 543734006458 active site 543734006459 Protein of unknown function (DUF460); Region: DUF460; pfam04312 543734006460 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 543734006461 EamA-like transporter family; Region: EamA; cl01037 543734006462 EamA-like transporter family; Region: EamA; cl01037 543734006463 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 543734006464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 543734006465 Ligand Binding Site [chemical binding]; other site 543734006466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734006467 non-specific DNA binding site [nucleotide binding]; other site 543734006468 salt bridge; other site 543734006469 sequence-specific DNA binding site [nucleotide binding]; other site 543734006470 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 543734006471 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 543734006472 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 543734006473 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 543734006474 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 543734006475 HEAT repeats; Region: HEAT_2; pfam13646 543734006476 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734006477 Helix-turn-helix domains; Region: HTH; cl00088 543734006478 Integrase core domain; Region: rve; cl01316 543734006479 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 543734006480 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 543734006481 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 543734006482 DNA binding residues [nucleotide binding] 543734006483 putative dimer interface [polypeptide binding]; other site 543734006484 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734006485 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 543734006486 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 543734006487 catalytic Zn binding site [ion binding]; other site 543734006488 NAD(P) binding site [chemical binding]; other site 543734006489 structural Zn binding site [ion binding]; other site 543734006490 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 543734006491 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734006492 putative NAD(P) binding site [chemical binding]; other site 543734006493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734006494 S-adenosylmethionine binding site [chemical binding]; other site 543734006495 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 543734006496 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 543734006497 catalytic triad [active] 543734006498 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 543734006499 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 543734006500 Domain of unknown function DUF21; Region: DUF21; pfam01595 543734006501 FOG: CBS domain [General function prediction only]; Region: COG0517 543734006502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 543734006503 Transporter associated domain; Region: CorC_HlyC; cl08393 543734006504 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734006505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006506 Maf-like protein; Region: Maf; pfam02545 543734006507 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 543734006508 active site 543734006509 dimer interface [polypeptide binding]; other site 543734006510 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 543734006511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734006512 ATP binding site [chemical binding]; other site 543734006513 Mg2+ binding site [ion binding]; other site 543734006514 G-X-G motif; other site 543734006515 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 543734006516 ATP binding site [chemical binding]; other site 543734006517 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 543734006518 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 543734006519 MutS domain I; Region: MutS_I; pfam01624 543734006520 MutS domain II; Region: MutS_II; pfam05188 543734006521 MutS family domain IV; Region: MutS_IV; pfam05190 543734006522 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 543734006523 Walker A/P-loop; other site 543734006524 ATP binding site [chemical binding]; other site 543734006525 Q-loop/lid; other site 543734006526 ABC transporter signature motif; other site 543734006527 Walker B; other site 543734006528 D-loop; other site 543734006529 H-loop/switch region; other site 543734006530 Amino acid permease; Region: AA_permease_2; pfam13520 543734006531 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 543734006532 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 543734006533 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 543734006534 ring oligomerisation interface [polypeptide binding]; other site 543734006535 ATP/Mg binding site [chemical binding]; other site 543734006536 stacking interactions; other site 543734006537 hinge regions; other site 543734006538 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 543734006539 oligomerisation interface [polypeptide binding]; other site 543734006540 mobile loop; other site 543734006541 roof hairpin; other site 543734006542 CAAX protease self-immunity; Region: Abi; cl00558 543734006543 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 543734006544 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734006545 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 543734006546 Walker A/P-loop; other site 543734006547 ATP binding site [chemical binding]; other site 543734006548 Q-loop/lid; other site 543734006549 ABC transporter signature motif; other site 543734006550 Walker B; other site 543734006551 D-loop; other site 543734006552 H-loop/switch region; other site 543734006553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734006554 DNA-binding site [nucleotide binding]; DNA binding site 543734006555 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 543734006556 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 543734006557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 543734006559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006560 Walker A/P-loop; other site 543734006561 ATP binding site [chemical binding]; other site 543734006562 Q-loop/lid; other site 543734006563 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734006564 ABC transporter signature motif; other site 543734006565 Walker B; other site 543734006566 D-loop; other site 543734006567 ABC transporter; Region: ABC_tran_2; pfam12848 543734006568 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 543734006569 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734006570 active site 543734006571 P-loop; other site 543734006572 phosphorylation site [posttranslational modification] 543734006573 UGMP family protein; Validated; Region: PRK09604 543734006574 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 543734006575 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 543734006576 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 543734006577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734006578 Coenzyme A binding pocket [chemical binding]; other site 543734006579 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 543734006580 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 543734006581 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 543734006582 active site 543734006583 homotetramer interface [polypeptide binding]; other site 543734006584 homodimer interface [polypeptide binding]; other site 543734006585 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 543734006586 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 543734006587 active site 543734006588 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 543734006589 active site 2 [active] 543734006590 active site 1 [active] 543734006591 Predicted methyltransferases [General function prediction only]; Region: COG0313 543734006592 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 543734006593 Protein of unknown function (DUF972); Region: DUF972; pfam06156 543734006594 DNA polymerase III subunit delta'; Validated; Region: PRK08058 543734006595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006596 Nitrogen regulatory protein P-II; Region: P-II; cl00412 543734006597 thymidylate kinase; Validated; Region: tmk; PRK00698 543734006598 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 543734006599 TMP-binding site; other site 543734006600 ATP-binding site [chemical binding]; other site 543734006601 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 543734006602 recombination protein RecR; Reviewed; Region: recR; PRK00076 543734006603 RecR protein; Region: RecR; pfam02132 543734006604 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 543734006605 putative active site [active] 543734006606 putative metal-binding site [ion binding]; other site 543734006607 tetramer interface [polypeptide binding]; other site 543734006608 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 543734006609 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 543734006610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734006611 Walker A motif; other site 543734006612 ATP binding site [chemical binding]; other site 543734006613 Walker B motif; other site 543734006614 arginine finger; other site 543734006615 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 543734006616 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 543734006617 nucleoside/Zn binding site; other site 543734006618 dimer interface [polypeptide binding]; other site 543734006619 catalytic motif [active] 543734006620 Methyltransferase domain; Region: Methyltransf_31; pfam13847 543734006621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734006622 S-adenosylmethionine binding site [chemical binding]; other site 543734006623 Predicted integral membrane protein [Function unknown]; Region: COG0392 543734006624 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 543734006625 Uncharacterized conserved protein [Function unknown]; Region: COG2898 543734006626 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 543734006627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 543734006628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 543734006629 DNA binding site [nucleotide binding] 543734006630 domain linker motif; other site 543734006631 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 543734006632 putative dimerization interface [polypeptide binding]; other site 543734006633 putative ligand binding site [chemical binding]; other site 543734006634 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 543734006635 putative active site [active] 543734006636 catalytic triad [active] 543734006637 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 543734006638 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 543734006639 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 543734006640 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 543734006641 PPIC-type PPIASE domain; Region: Rotamase; cl08278 543734006642 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 543734006643 core dimer interface [polypeptide binding]; other site 543734006644 peripheral dimer interface [polypeptide binding]; other site 543734006645 L10 interface [polypeptide binding]; other site 543734006646 L11 interface [polypeptide binding]; other site 543734006647 putative EF-Tu interaction site [polypeptide binding]; other site 543734006648 putative EF-G interaction site [polypeptide binding]; other site 543734006649 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 543734006650 23S rRNA interface [nucleotide binding]; other site 543734006651 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 543734006652 drug efflux system protein MdtG; Provisional; Region: PRK09874 543734006653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006654 putative substrate translocation pore; other site 543734006655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006656 putative substrate translocation pore; other site 543734006657 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 543734006658 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 543734006659 NAD(P) binding site [chemical binding]; other site 543734006660 catalytic residues [active] 543734006661 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 543734006662 mRNA/rRNA interface [nucleotide binding]; other site 543734006663 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 543734006664 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 543734006665 23S rRNA interface [nucleotide binding]; other site 543734006666 L7/L12 interface [polypeptide binding]; other site 543734006667 putative thiostrepton binding site; other site 543734006668 L25 interface [polypeptide binding]; other site 543734006669 magnesium-transporting ATPase; Provisional; Region: PRK15122 543734006670 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734006671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734006672 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734006673 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734006674 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734006675 amidase; Provisional; Region: PRK06529 543734006676 Amidase; Region: Amidase; cl11426 543734006677 Protein of unknown function (DUF419); Region: DUF419; cl15265 543734006678 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 543734006679 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 543734006680 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 543734006681 TIR domain; Region: TIR_2; cl15770 543734006682 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734006683 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 543734006684 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 543734006685 putative homodimer interface [polypeptide binding]; other site 543734006686 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 543734006687 UbiA prenyltransferase family; Region: UbiA; cl00337 543734006688 UbiA prenyltransferase family; Region: UbiA; cl00337 543734006689 ApbE family; Region: ApbE; cl00643 543734006690 FMN-binding domain; Region: FMN_bind; cl01081 543734006691 FMN-binding domain; Region: FMN_bind; cl01081 543734006692 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 543734006693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734006694 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 543734006695 trimer interface [polypeptide binding]; other site 543734006696 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 543734006697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 543734006698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 543734006699 substrate binding pocket [chemical binding]; other site 543734006700 chain length determination region; other site 543734006701 substrate-Mg2+ binding site; other site 543734006702 catalytic residues [active] 543734006703 aspartate-rich region 1; other site 543734006704 active site lid residues [active] 543734006705 aspartate-rich region 2; other site 543734006706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006708 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 543734006709 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 543734006710 YacP-like NYN domain; Region: NYN_YacP; cl01491 543734006711 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 543734006712 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 543734006713 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 543734006714 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 543734006715 active site 543734006716 metal binding site [ion binding]; metal-binding site 543734006717 dimerization interface [polypeptide binding]; other site 543734006718 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 543734006719 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 543734006720 active site 543734006721 HIGH motif; other site 543734006722 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 543734006723 KMSKS motif; other site 543734006724 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 543734006725 tRNA binding surface [nucleotide binding]; other site 543734006726 anticodon binding site; other site 543734006727 FAD binding domain; Region: FAD_binding_4; pfam01565 543734006728 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 543734006729 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 543734006730 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 543734006731 active site 543734006732 HIGH motif; other site 543734006733 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 543734006734 active site 543734006735 KMSKS motif; other site 543734006736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 543734006737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006738 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 543734006739 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734006740 active site 543734006741 dimer interface [polypeptide binding]; other site 543734006742 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 543734006743 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 543734006744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 543734006745 putative active site [active] 543734006746 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 543734006747 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 543734006748 Predicted membrane protein [General function prediction only]; Region: COG4194 543734006749 Predicted transcriptional regulators [Transcription]; Region: COG1725 543734006750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734006751 DNA-binding site [nucleotide binding]; DNA binding site 543734006752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734006753 putative DNA binding site [nucleotide binding]; other site 543734006754 dimerization interface [polypeptide binding]; other site 543734006755 putative Zn2+ binding site [ion binding]; other site 543734006756 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 543734006757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006758 Walker A/P-loop; other site 543734006759 ATP binding site [chemical binding]; other site 543734006760 Q-loop/lid; other site 543734006761 ABC transporter signature motif; other site 543734006762 Walker B; other site 543734006763 D-loop; other site 543734006764 H-loop/switch region; other site 543734006765 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 543734006766 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734006767 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734006768 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 543734006769 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 543734006770 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 543734006771 ABC-2 type transporter; Region: ABC2_membrane; cl11417 543734006772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734006773 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 543734006774 Walker A/P-loop; other site 543734006775 ATP binding site [chemical binding]; other site 543734006776 Q-loop/lid; other site 543734006777 ABC transporter signature motif; other site 543734006778 Walker B; other site 543734006779 D-loop; other site 543734006780 H-loop/switch region; other site 543734006781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734006782 non-specific DNA binding site [nucleotide binding]; other site 543734006783 salt bridge; other site 543734006784 sequence-specific DNA binding site [nucleotide binding]; other site 543734006785 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 543734006786 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 543734006787 putative active site [active] 543734006788 DNA repair protein RadA; Provisional; Region: PRK11823 543734006789 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 543734006790 Walker A motif/ATP binding site; other site 543734006791 ATP binding site [chemical binding]; other site 543734006792 Walker B motif; other site 543734006793 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 543734006794 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 543734006795 trimer interface [polypeptide binding]; other site 543734006796 active site 543734006797 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734006798 Protein of unknown function (DUF805); Region: DUF805; cl01224 543734006799 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 543734006800 trimer interface [polypeptide binding]; other site 543734006801 active site 543734006802 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 543734006803 trimer interface [polypeptide binding]; other site 543734006804 active site 543734006805 G bulge; other site 543734006806 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 543734006807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006808 Walker A/P-loop; other site 543734006809 ATP binding site [chemical binding]; other site 543734006810 Q-loop/lid; other site 543734006811 ABC transporter signature motif; other site 543734006812 Walker B; other site 543734006813 D-loop; other site 543734006814 H-loop/switch region; other site 543734006815 K+ potassium transporter; Region: K_trans; cl15781 543734006816 pyruvate phosphate dikinase; Provisional; Region: PRK09279 543734006817 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 543734006818 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 543734006819 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 543734006820 Helix-turn-helix domains; Region: HTH; cl00088 543734006821 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 543734006822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734006823 catalytic core [active] 543734006824 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 543734006825 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 543734006826 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 543734006827 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 543734006828 teramer interface [polypeptide binding]; other site 543734006829 active site 543734006830 FMN binding site [chemical binding]; other site 543734006831 catalytic residues [active] 543734006832 CsbD-like; Region: CsbD; cl15799 543734006833 Sulfatase; Region: Sulfatase; cl10460 543734006834 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 543734006835 benzoate transport; Region: 2A0115; TIGR00895 543734006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006837 putative substrate translocation pore; other site 543734006838 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 543734006839 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 543734006840 benzoate transport; Region: 2A0115; TIGR00895 543734006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006842 putative substrate translocation pore; other site 543734006843 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 543734006844 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 543734006845 Helix-turn-helix domains; Region: HTH; cl00088 543734006846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006847 H+ Antiporter protein; Region: 2A0121; TIGR00900 543734006848 putative substrate translocation pore; other site 543734006849 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 543734006850 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 543734006851 putative catalytic cysteine [active] 543734006852 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 543734006853 nucleotide binding site [chemical binding]; other site 543734006854 homotetrameric interface [polypeptide binding]; other site 543734006855 putative phosphate binding site [ion binding]; other site 543734006856 putative allosteric binding site; other site 543734006857 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 543734006858 active site 543734006859 catalytic site [active] 543734006860 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734006861 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734006862 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734006863 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 543734006864 Uncharacterized conserved protein [Function unknown]; Region: COG3410 543734006865 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 543734006866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 543734006867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734006868 non-specific DNA binding site [nucleotide binding]; other site 543734006869 salt bridge; other site 543734006870 sequence-specific DNA binding site [nucleotide binding]; other site 543734006871 Helix-turn-helix domains; Region: HTH; cl00088 543734006872 Enterocin A Immunity; Region: EntA_Immun; pfam08951 543734006873 Enterocin A Immunity; Region: EntA_Immun; pfam08951 543734006874 Enterocin A Immunity; Region: EntA_Immun; pfam08951 543734006875 Uncharacterized conserved protein [Function unknown]; Region: COG2966 543734006876 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734006877 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734006878 hypothetical protein 543734006879 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 543734006880 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 543734006881 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 543734006882 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 543734006883 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 543734006884 putative active site [active] 543734006885 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 543734006886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734006887 Walker A/P-loop; other site 543734006888 ATP binding site [chemical binding]; other site 543734006889 Q-loop/lid; other site 543734006890 ABC transporter signature motif; other site 543734006891 Walker B; other site 543734006892 D-loop; other site 543734006893 H-loop/switch region; other site 543734006894 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 543734006895 putative active site [active] 543734006896 sensory histidine kinase DcuS; Provisional; Region: PRK11086 543734006897 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 543734006898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734006899 active site 543734006900 phosphorylation site [posttranslational modification] 543734006901 intermolecular recognition site; other site 543734006902 dimerization interface [polypeptide binding]; other site 543734006903 LytTr DNA-binding domain; Region: LytTR; cl04498 543734006904 CAAX protease self-immunity; Region: Abi; cl00558 543734006905 CAAX protease self-immunity; Region: Abi; cl00558 543734006906 Enterocin A Immunity; Region: EntA_Immun; pfam08951 543734006907 maltose O-acetyltransferase; Provisional; Region: PRK10092 543734006908 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 543734006909 active site 543734006910 substrate binding site [chemical binding]; other site 543734006911 trimer interface [polypeptide binding]; other site 543734006912 CoA binding site [chemical binding]; other site 543734006913 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734006914 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734006915 active site 543734006916 catalytic tetrad [active] 543734006917 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 543734006918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734006919 NAD(P) binding site [chemical binding]; other site 543734006920 active site 543734006921 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 543734006922 putative active site [active] 543734006923 putative FMN binding site [chemical binding]; other site 543734006924 putative substrate binding site [chemical binding]; other site 543734006925 putative catalytic residue [active] 543734006926 fumarate hydratase; Reviewed; Region: fumC; PRK00485 543734006927 Class II fumarases; Region: Fumarase_classII; cd01362 543734006928 active site 543734006929 tetramer interface [polypeptide binding]; other site 543734006930 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 543734006931 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 543734006932 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 543734006933 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 543734006934 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734006935 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 543734006936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734006937 motif II; other site 543734006938 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 543734006939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734006940 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 543734006941 putative substrate translocation pore; other site 543734006942 multicopper oxidase; Provisional; Region: PRK10965 543734006943 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 543734006944 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 543734006945 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 543734006946 Cation efflux family; Region: Cation_efflux; cl00316 543734006947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 543734006948 dimerization interface [polypeptide binding]; other site 543734006949 putative DNA binding site [nucleotide binding]; other site 543734006950 putative Zn2+ binding site [ion binding]; other site 543734006951 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 543734006952 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 543734006953 metal binding site [ion binding]; metal-binding site 543734006954 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 543734006955 ABC-ATPase subunit interface; other site 543734006956 dimer interface [polypeptide binding]; other site 543734006957 putative PBP binding regions; other site 543734006958 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 543734006959 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 543734006960 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 543734006961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 543734006962 NAD binding site [chemical binding]; other site 543734006963 catalytic residues [active] 543734006964 substrate binding site [chemical binding]; other site 543734006965 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 543734006966 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734006967 Helix-turn-helix domains; Region: HTH; cl00088 543734006968 Integrase core domain; Region: rve; cl01316 543734006969 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 543734006970 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 543734006971 metal binding site [ion binding]; metal-binding site 543734006972 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 543734006973 NADH(P)-binding; Region: NAD_binding_10; pfam13460 543734006974 putative NAD(P) binding site [chemical binding]; other site 543734006975 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 543734006976 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 543734006977 nudix motif; other site 543734006978 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 543734006979 Collagen binding domain; Region: Collagen_bind; pfam05737 543734006980 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734006981 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 543734006982 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 543734006983 metal binding site [ion binding]; metal-binding site 543734006984 hypothetical protein 543734006985 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734006986 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 543734006987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734006988 Walker A motif; other site 543734006989 ATP binding site [chemical binding]; other site 543734006990 Walker B motif; other site 543734006991 CrcB-like protein; Region: CRCB; cl09114 543734006992 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734006993 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 543734006994 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 543734006995 membrane-bound complex binding site; other site 543734006996 hinge residues; other site 543734006997 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 543734006998 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 543734006999 Walker A/P-loop; other site 543734007000 ATP binding site [chemical binding]; other site 543734007001 Q-loop/lid; other site 543734007002 ABC transporter signature motif; other site 543734007003 Walker B; other site 543734007004 D-loop; other site 543734007005 H-loop/switch region; other site 543734007006 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 543734007007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734007008 dimer interface [polypeptide binding]; other site 543734007009 conserved gate region; other site 543734007010 putative PBP binding loops; other site 543734007011 ABC-ATPase subunit interface; other site 543734007012 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 543734007013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734007014 dimer interface [polypeptide binding]; other site 543734007015 conserved gate region; other site 543734007016 putative PBP binding loops; other site 543734007017 ABC-ATPase subunit interface; other site 543734007018 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734007019 Helix-turn-helix domains; Region: HTH; cl00088 543734007020 Integrase core domain; Region: rve; cl01316 543734007021 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 543734007022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734007023 substrate binding pocket [chemical binding]; other site 543734007024 membrane-bound complex binding site; other site 543734007025 hinge residues; other site 543734007026 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 543734007027 AMP-binding enzyme; Region: AMP-binding; cl15778 543734007028 AMP-binding enzyme; Region: AMP-binding; cl15778 543734007029 Acyltransferase family; Region: Acyl_transf_3; pfam01757 543734007030 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 543734007031 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007032 Walker A/P-loop; other site 543734007033 ATP binding site [chemical binding]; other site 543734007034 Q-loop/lid; other site 543734007035 ABC transporter signature motif; other site 543734007036 Walker B; other site 543734007037 D-loop; other site 543734007038 H-loop/switch region; other site 543734007039 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 543734007040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734007041 putative PBP binding loops; other site 543734007042 dimer interface [polypeptide binding]; other site 543734007043 ABC-ATPase subunit interface; other site 543734007044 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 543734007045 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 543734007046 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 543734007047 ABC transporter; Region: ABC_tran; pfam00005 543734007048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007049 Q-loop/lid; other site 543734007050 ABC transporter signature motif; other site 543734007051 Walker B; other site 543734007052 D-loop; other site 543734007053 H-loop/switch region; other site 543734007054 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 543734007055 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 543734007056 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 543734007057 23S rRNA interface [nucleotide binding]; other site 543734007058 L3 interface [polypeptide binding]; other site 543734007059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 543734007060 Helix-turn-helix domains; Region: HTH; cl00088 543734007061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734007062 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734007063 Walker A/P-loop; other site 543734007064 ATP binding site [chemical binding]; other site 543734007065 Q-loop/lid; other site 543734007066 ABC transporter signature motif; other site 543734007067 Walker B; other site 543734007068 D-loop; other site 543734007069 H-loop/switch region; other site 543734007070 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 543734007071 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 543734007072 DNA binding residues [nucleotide binding] 543734007073 dimer interface [polypeptide binding]; other site 543734007074 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 543734007075 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 543734007076 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 543734007077 dimerization interface 3.5A [polypeptide binding]; other site 543734007078 active site 543734007079 Cobalt transport protein; Region: CbiQ; cl00463 543734007080 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 543734007081 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734007082 Walker A/P-loop; other site 543734007083 ATP binding site [chemical binding]; other site 543734007084 Q-loop/lid; other site 543734007085 ABC transporter signature motif; other site 543734007086 Walker B; other site 543734007087 D-loop; other site 543734007088 H-loop/switch region; other site 543734007089 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 543734007090 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734007091 Walker A/P-loop; other site 543734007092 ATP binding site [chemical binding]; other site 543734007093 Q-loop/lid; other site 543734007094 ABC transporter signature motif; other site 543734007095 Walker B; other site 543734007096 D-loop; other site 543734007097 H-loop/switch region; other site 543734007098 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 543734007099 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 543734007100 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 543734007101 alphaNTD homodimer interface [polypeptide binding]; other site 543734007102 alphaNTD - beta interaction site [polypeptide binding]; other site 543734007103 alphaNTD - beta' interaction site [polypeptide binding]; other site 543734007104 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 543734007105 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 543734007106 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 543734007107 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 543734007108 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 543734007109 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 543734007110 rRNA binding site [nucleotide binding]; other site 543734007111 predicted 30S ribosome binding site; other site 543734007112 adenylate kinase; Reviewed; Region: adk; PRK00279 543734007113 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 543734007114 AMP-binding site [chemical binding]; other site 543734007115 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 543734007116 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 543734007117 SecY translocase; Region: SecY; pfam00344 543734007118 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 543734007119 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 543734007120 23S rRNA binding site [nucleotide binding]; other site 543734007121 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 543734007122 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 543734007123 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 543734007124 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 543734007125 5S rRNA interface [nucleotide binding]; other site 543734007126 L27 interface [polypeptide binding]; other site 543734007127 23S rRNA interface [nucleotide binding]; other site 543734007128 L5 interface [polypeptide binding]; other site 543734007129 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 543734007130 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 543734007131 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 543734007132 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 543734007133 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 543734007134 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 543734007135 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 543734007136 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 543734007137 KOW motif; Region: KOW; cl00354 543734007138 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 543734007139 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 543734007140 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 543734007141 23S rRNA interface [nucleotide binding]; other site 543734007142 putative translocon interaction site; other site 543734007143 signal recognition particle (SRP54) interaction site; other site 543734007144 L23 interface [polypeptide binding]; other site 543734007145 trigger factor interaction site; other site 543734007146 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 543734007147 23S rRNA interface [nucleotide binding]; other site 543734007148 5S rRNA interface [nucleotide binding]; other site 543734007149 putative antibiotic binding site [chemical binding]; other site 543734007150 L25 interface [polypeptide binding]; other site 543734007151 L27 interface [polypeptide binding]; other site 543734007152 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 543734007153 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 543734007154 G-X-X-G motif; other site 543734007155 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 543734007156 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 543734007157 putative translocon binding site; other site 543734007158 protein-rRNA interface [nucleotide binding]; other site 543734007159 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 543734007160 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 543734007161 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 543734007162 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 543734007163 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 543734007164 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 543734007165 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 543734007166 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 543734007167 Phosphate-starvation-inducible E; Region: PsiE; cl01264 543734007168 peroxiredoxin; Region: AhpC; TIGR03137 543734007169 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 543734007170 dimer interface [polypeptide binding]; other site 543734007171 decamer (pentamer of dimers) interface [polypeptide binding]; other site 543734007172 catalytic triad [active] 543734007173 peroxidatic and resolving cysteines [active] 543734007174 Predicted transcriptional regulator [Transcription]; Region: COG2378 543734007175 WYL domain; Region: WYL; cl14852 543734007176 elongation factor G; Reviewed; Region: PRK12739 543734007177 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 543734007178 G1 box; other site 543734007179 putative GEF interaction site [polypeptide binding]; other site 543734007180 GTP/Mg2+ binding site [chemical binding]; other site 543734007181 Switch I region; other site 543734007182 G2 box; other site 543734007183 G3 box; other site 543734007184 Switch II region; other site 543734007185 G4 box; other site 543734007186 G5 box; other site 543734007187 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 543734007188 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 543734007189 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 543734007190 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 543734007191 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 543734007192 S17 interaction site [polypeptide binding]; other site 543734007193 S8 interaction site; other site 543734007194 16S rRNA interaction site [nucleotide binding]; other site 543734007195 streptomycin interaction site [chemical binding]; other site 543734007196 23S rRNA interaction site [nucleotide binding]; other site 543734007197 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 543734007198 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 543734007199 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007200 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 543734007201 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007202 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007203 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007204 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 543734007205 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007206 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007207 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007208 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 543734007209 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007210 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007211 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007212 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 543734007213 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 543734007214 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 543734007215 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 543734007216 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 543734007217 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 543734007218 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 543734007219 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 543734007220 DNA binding site [nucleotide binding] 543734007221 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 543734007222 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 543734007223 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 543734007224 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 543734007225 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 543734007226 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 543734007227 RPB1 interaction site [polypeptide binding]; other site 543734007228 RPB10 interaction site [polypeptide binding]; other site 543734007229 RPB11 interaction site [polypeptide binding]; other site 543734007230 RPB3 interaction site [polypeptide binding]; other site 543734007231 RPB12 interaction site [polypeptide binding]; other site 543734007232 Clp protease ATP binding subunit; Region: clpC; CHL00095 543734007233 Clp amino terminal domain; Region: Clp_N; pfam02861 543734007234 Clp amino terminal domain; Region: Clp_N; pfam02861 543734007235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734007236 Walker A motif; other site 543734007237 ATP binding site [chemical binding]; other site 543734007238 Walker B motif; other site 543734007239 arginine finger; other site 543734007240 UvrB/uvrC motif; Region: UVR; pfam02151 543734007241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734007242 Walker A motif; other site 543734007243 ATP binding site [chemical binding]; other site 543734007244 Walker B motif; other site 543734007245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 543734007246 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 543734007247 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 543734007248 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 543734007249 dimer interface [polypeptide binding]; other site 543734007250 putative anticodon binding site; other site 543734007251 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 543734007252 motif 1; other site 543734007253 active site 543734007254 motif 2; other site 543734007255 motif 3; other site 543734007256 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 543734007257 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 543734007258 FMN binding site [chemical binding]; other site 543734007259 active site 543734007260 catalytic residues [active] 543734007261 substrate binding site [chemical binding]; other site 543734007262 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 543734007263 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 543734007264 dimerization interface [polypeptide binding]; other site 543734007265 domain crossover interface; other site 543734007266 redox-dependent activation switch; other site 543734007267 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734007268 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734007269 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 543734007270 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 543734007271 legume lectins; Region: lectin_L-type; cl14058 543734007272 homotetramer interaction site [polypeptide binding]; other site 543734007273 homodimer interaction site [polypeptide binding]; other site 543734007274 carbohydrate binding site [chemical binding]; other site 543734007275 metal binding site [ion binding]; metal-binding site 543734007276 WxL domain surface cell wall-binding; Region: WxL; pfam13731 543734007277 FtsH Extracellular; Region: FtsH_ext; pfam06480 543734007278 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 543734007279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734007280 Walker A motif; other site 543734007281 ATP binding site [chemical binding]; other site 543734007282 Walker B motif; other site 543734007283 arginine finger; other site 543734007284 Peptidase family M41; Region: Peptidase_M41; pfam01434 543734007285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734007286 active site 543734007287 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 543734007288 Ligand Binding Site [chemical binding]; other site 543734007289 B3/4 domain; Region: B3_4; cl11458 543734007290 hypothetical protein; Provisional; Region: PRK08582 543734007291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 543734007292 RNA binding site [nucleotide binding]; other site 543734007293 Septum formation initiator; Region: DivIC; cl11433 543734007294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 543734007295 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 543734007296 MatE; Region: MatE; cl10513 543734007297 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 543734007298 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 543734007299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 543734007300 ATP binding site [chemical binding]; other site 543734007301 putative Mg++ binding site [ion binding]; other site 543734007302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734007303 nucleotide binding region [chemical binding]; other site 543734007304 ATP-binding site [chemical binding]; other site 543734007305 TRCF domain; Region: TRCF; cl04088 543734007306 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 543734007307 putative active site [active] 543734007308 catalytic residue [active] 543734007309 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 543734007310 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 543734007311 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734007312 NAD binding site [chemical binding]; other site 543734007313 dimer interface [polypeptide binding]; other site 543734007314 substrate binding site [chemical binding]; other site 543734007315 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 543734007316 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 543734007317 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 543734007318 Helix-turn-helix domains; Region: HTH; cl00088 543734007319 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 543734007320 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 543734007321 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 543734007322 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 543734007323 FOG: CBS domain [General function prediction only]; Region: COG0517 543734007324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 543734007325 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 543734007326 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 543734007327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007328 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 543734007329 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 543734007330 active site 543734007331 dimer interface [polypeptide binding]; other site 543734007332 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 543734007333 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 543734007334 active site 543734007335 FMN binding site [chemical binding]; other site 543734007336 substrate binding site [chemical binding]; other site 543734007337 3Fe-4S cluster binding site [ion binding]; other site 543734007338 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 543734007339 domain interface; other site 543734007340 QueT transporter; Region: QueT; cl01932 543734007341 PemK-like protein; Region: PemK; cl00995 543734007342 hypothetical protein; Region: PHA01623 543734007343 alanine racemase; Reviewed; Region: alr; PRK00053 543734007344 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 543734007345 active site 543734007346 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 543734007347 dimer interface [polypeptide binding]; other site 543734007348 substrate binding site [chemical binding]; other site 543734007349 catalytic residues [active] 543734007350 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 543734007351 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 543734007352 DEAD-like helicases superfamily; Region: DEXDc; smart00487 543734007353 ATP binding site [chemical binding]; other site 543734007354 Mg++ binding site [ion binding]; other site 543734007355 motif III; other site 543734007356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 543734007357 nucleotide binding region [chemical binding]; other site 543734007358 ATP-binding site [chemical binding]; other site 543734007359 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 543734007360 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 543734007361 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 543734007362 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 543734007363 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 543734007364 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 543734007365 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 543734007366 hinge; other site 543734007367 active site 543734007368 CTP synthetase; Validated; Region: pyrG; PRK05380 543734007369 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 543734007370 Catalytic site [active] 543734007371 active site 543734007372 UTP binding site [chemical binding]; other site 543734007373 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 543734007374 active site 543734007375 putative oxyanion hole; other site 543734007376 catalytic triad [active] 543734007377 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 543734007378 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 543734007379 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 543734007380 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 543734007381 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 543734007382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 543734007383 Zn2+ binding site [ion binding]; other site 543734007384 Mg2+ binding site [ion binding]; other site 543734007385 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 543734007386 putative active site [active] 543734007387 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 543734007388 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 543734007389 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 543734007390 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 543734007391 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 543734007392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734007393 active site 543734007394 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 543734007395 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 543734007396 Substrate binding site; other site 543734007397 Mg++ binding site; other site 543734007398 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 543734007399 active site 543734007400 substrate binding site [chemical binding]; other site 543734007401 CoA binding site [chemical binding]; other site 543734007402 VanZ like family; Region: VanZ; cl01971 543734007403 RDD family; Region: RDD; cl00746 543734007404 pur operon repressor; Provisional; Region: PRK09213 543734007405 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 543734007406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734007407 active site 543734007408 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 543734007409 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 543734007410 Walker A/P-loop; other site 543734007411 ATP binding site [chemical binding]; other site 543734007412 Q-loop/lid; other site 543734007413 ABC transporter signature motif; other site 543734007414 Walker B; other site 543734007415 D-loop; other site 543734007416 H-loop/switch region; other site 543734007417 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 543734007418 Cation efflux family; Region: Cation_efflux; cl00316 543734007419 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 543734007420 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 543734007421 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 543734007422 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 543734007423 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 543734007424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007425 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 543734007426 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 543734007427 putative active site [active] 543734007428 putative metal binding site [ion binding]; other site 543734007429 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 543734007430 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 543734007431 active site 543734007432 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734007433 active site 543734007434 phosphorylation site [posttranslational modification] 543734007435 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734007436 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 543734007437 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 543734007438 active site 543734007439 catalytic residues [active] 543734007440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734007441 active site 543734007442 phosphorylation site [posttranslational modification] 543734007443 intermolecular recognition site; other site 543734007444 dimerization interface [polypeptide binding]; other site 543734007445 LytTr DNA-binding domain; Region: LytTR; cl04498 543734007446 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 543734007447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 543734007448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734007449 Transmembrane protein 231; Region: TM231; pfam10149 543734007450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007451 Walker A/P-loop; other site 543734007452 ATP binding site [chemical binding]; other site 543734007453 Q-loop/lid; other site 543734007454 ABC transporter signature motif; other site 543734007455 Walker B; other site 543734007456 D-loop; other site 543734007457 H-loop/switch region; other site 543734007458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 543734007459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007460 Walker A/P-loop; other site 543734007461 ATP binding site [chemical binding]; other site 543734007462 Q-loop/lid; other site 543734007463 ABC transporter signature motif; other site 543734007464 Walker B; other site 543734007465 D-loop; other site 543734007466 H-loop/switch region; other site 543734007467 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 543734007468 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 543734007469 active site 543734007470 HIGH motif; other site 543734007471 KMSKS motif; other site 543734007472 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 543734007473 tRNA binding surface [nucleotide binding]; other site 543734007474 anticodon binding site; other site 543734007475 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 543734007476 dimer interface [polypeptide binding]; other site 543734007477 putative tRNA-binding site [nucleotide binding]; other site 543734007478 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 543734007479 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734007480 Protein of unknown function DUF72; Region: DUF72; cl00777 543734007481 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 543734007482 putative active site [active] 543734007483 nucleotide binding site [chemical binding]; other site 543734007484 nudix motif; other site 543734007485 putative metal binding site [ion binding]; other site 543734007486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007487 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 543734007488 LDH/MDH dimer interface [polypeptide binding]; other site 543734007489 NAD(P) binding site [chemical binding]; other site 543734007490 substrate binding site [chemical binding]; other site 543734007491 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 543734007492 NAD-dependent deacetylase; Provisional; Region: PRK00481 543734007493 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 543734007494 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 543734007495 substrate binding site [chemical binding]; other site 543734007496 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 543734007497 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 543734007498 polyphosphate kinase; Provisional; Region: PRK05443 543734007499 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 543734007500 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 543734007501 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 543734007502 putative domain interface [polypeptide binding]; other site 543734007503 putative active site [active] 543734007504 catalytic site [active] 543734007505 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 543734007506 putative domain interface [polypeptide binding]; other site 543734007507 putative active site [active] 543734007508 catalytic site [active] 543734007509 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 543734007510 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 543734007511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734007512 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 543734007513 active site 543734007514 catalytic tetrad [active] 543734007515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734007517 S-adenosylmethionine binding site [chemical binding]; other site 543734007518 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 543734007519 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734007520 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 543734007521 MatE; Region: MatE; cl10513 543734007522 MatE; Region: MatE; cl10513 543734007523 Repair protein; Region: Repair_PSII; cl01535 543734007524 LemA family; Region: LemA; cl00742 543734007525 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 543734007526 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 543734007527 active site 543734007528 HIGH motif; other site 543734007529 dimer interface [polypeptide binding]; other site 543734007530 KMSKS motif; other site 543734007531 FtsX-like permease family; Region: FtsX; cl15850 543734007532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734007533 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734007534 Walker A/P-loop; other site 543734007535 ATP binding site [chemical binding]; other site 543734007536 Q-loop/lid; other site 543734007537 ABC transporter signature motif; other site 543734007538 Walker B; other site 543734007539 D-loop; other site 543734007540 H-loop/switch region; other site 543734007541 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 543734007542 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 543734007543 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 543734007544 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 543734007545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007546 Walker A/P-loop; other site 543734007547 ATP binding site [chemical binding]; other site 543734007548 Q-loop/lid; other site 543734007549 ABC transporter signature motif; other site 543734007550 Walker B; other site 543734007551 D-loop; other site 543734007552 H-loop/switch region; other site 543734007553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734007554 conserved gate region; other site 543734007555 ABC-ATPase subunit interface; other site 543734007556 NMT1-like family; Region: NMT1_2; cl15260 543734007557 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 543734007558 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 543734007559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007560 Family description; Region: UvrD_C_2; cl15862 543734007561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734007562 Helix-turn-helix domains; Region: HTH; cl00088 543734007563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734007564 dimerization interface [polypeptide binding]; other site 543734007565 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 543734007566 gating phenylalanine in ion channel; other site 543734007567 CAAX protease self-immunity; Region: Abi; cl00558 543734007568 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 543734007569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 543734007570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 543734007571 Helix-turn-helix domains; Region: HTH; cl00088 543734007572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007573 Walker A/P-loop; other site 543734007574 ATP binding site [chemical binding]; other site 543734007575 Q-loop/lid; other site 543734007576 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 543734007577 Zn binding sites [ion binding]; other site 543734007578 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007579 ABC transporter signature motif; other site 543734007580 Walker B; other site 543734007581 D-loop; other site 543734007582 H-loop/switch region; other site 543734007583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734007584 Walker A/P-loop; other site 543734007585 ATP binding site [chemical binding]; other site 543734007586 Q-loop/lid; other site 543734007587 ABC transporter signature motif; other site 543734007588 Walker B; other site 543734007589 D-loop; other site 543734007590 H-loop/switch region; other site 543734007591 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 543734007592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734007593 active site 543734007594 catalytic tetrad [active] 543734007595 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734007596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734007597 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 543734007598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 543734007599 catalytic core [active] 543734007600 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 543734007601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734007602 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734007603 active site 543734007604 motif I; other site 543734007605 motif II; other site 543734007606 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734007607 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 543734007608 RNA/DNA hybrid binding site [nucleotide binding]; other site 543734007609 active site 543734007610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 543734007611 Helix-turn-helix domains; Region: HTH; cl00088 543734007612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 543734007613 dimerization interface [polypeptide binding]; other site 543734007614 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 543734007615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734007616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734007617 homodimer interface [polypeptide binding]; other site 543734007618 catalytic residue [active] 543734007619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734007620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734007621 putative substrate translocation pore; other site 543734007622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734007623 putative substrate translocation pore; other site 543734007624 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 543734007625 Helix-turn-helix domains; Region: HTH; cl00088 543734007626 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 543734007627 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 543734007628 protein RecA; Region: tigrfam_recA; TIGR02012 543734007629 hexamer interface [polypeptide binding]; other site 543734007630 Walker A motif; other site 543734007631 ATP binding site [chemical binding]; other site 543734007632 Walker B motif; other site 543734007633 Protein of unknown function (DUF554); Region: DUF554; cl00784 543734007634 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 543734007635 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 543734007636 P-loop; other site 543734007637 active site 543734007638 phosphorylation site [posttranslational modification] 543734007639 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734007640 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734007641 active site 543734007642 phosphorylation site [posttranslational modification] 543734007643 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 543734007644 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 543734007645 putative substrate binding site [chemical binding]; other site 543734007646 putative ATP binding site [chemical binding]; other site 543734007647 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 543734007648 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 543734007649 putative active site [active] 543734007650 glycerol kinase; Provisional; Region: glpK; PRK00047 543734007651 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 543734007652 N- and C-terminal domain interface [polypeptide binding]; other site 543734007653 active site 543734007654 MgATP binding site [chemical binding]; other site 543734007655 catalytic site [active] 543734007656 metal binding site [ion binding]; metal-binding site 543734007657 glycerol binding site [chemical binding]; other site 543734007658 homotetramer interface [polypeptide binding]; other site 543734007659 homodimer interface [polypeptide binding]; other site 543734007660 FBP binding site [chemical binding]; other site 543734007661 protein IIAGlc interface [polypeptide binding]; other site 543734007662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734007663 DNA-binding site [nucleotide binding]; DNA binding site 543734007664 UTRA domain; Region: UTRA; cl01230 543734007665 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 543734007666 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734007667 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 543734007668 active pocket/dimerization site; other site 543734007669 active site 543734007670 phosphorylation site [posttranslational modification] 543734007671 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 543734007672 active site 543734007673 phosphorylation site [posttranslational modification] 543734007674 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734007675 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734007676 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734007677 active site 543734007678 methionine cluster; other site 543734007679 phosphorylation site [posttranslational modification] 543734007680 metal binding site [ion binding]; metal-binding site 543734007681 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734007682 active site 543734007683 P-loop; other site 543734007684 phosphorylation site [posttranslational modification] 543734007685 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 543734007686 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 543734007687 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 543734007688 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 543734007689 alpha-mannosidase; Provisional; Region: PRK09819 543734007690 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 543734007691 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 543734007692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734007693 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 543734007694 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734007695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734007696 DNA-binding site [nucleotide binding]; DNA binding site 543734007697 UTRA domain; Region: UTRA; cl01230 543734007698 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 543734007699 intersubunit interface [polypeptide binding]; other site 543734007700 active site 543734007701 Zn2+ binding site [ion binding]; other site 543734007702 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734007703 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 543734007704 P-loop; other site 543734007705 active site 543734007706 phosphorylation site [posttranslational modification] 543734007707 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734007708 active site 543734007709 phosphorylation site [posttranslational modification] 543734007710 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734007711 Helix-turn-helix domains; Region: HTH; cl00088 543734007712 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734007713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 543734007714 S-adenosylmethionine binding site [chemical binding]; other site 543734007715 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 543734007716 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 543734007717 Ca binding site [ion binding]; other site 543734007718 active site 543734007719 catalytic site [active] 543734007720 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 543734007721 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 543734007722 Preprotein translocase subunit; Region: YajC; cl00806 543734007723 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 543734007724 active pocket/dimerization site; other site 543734007725 active site 543734007726 phosphorylation site [posttranslational modification] 543734007727 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734007728 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734007729 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734007730 active site 543734007731 phosphorylation site [posttranslational modification] 543734007732 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 543734007733 Transcriptional regulator [Transcription]; Region: IclR; COG1414 543734007734 Helix-turn-helix domains; Region: HTH; cl00088 543734007735 Bacterial transcriptional regulator; Region: IclR; pfam01614 543734007736 KduI/IolB family; Region: KduI; cl01508 543734007737 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 543734007738 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 543734007739 NADP binding site [chemical binding]; other site 543734007740 homodimer interface [polypeptide binding]; other site 543734007741 active site 543734007742 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 543734007743 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 543734007744 active site 543734007745 intersubunit interface [polypeptide binding]; other site 543734007746 catalytic residue [active] 543734007747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 543734007748 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 543734007749 substrate binding site [chemical binding]; other site 543734007750 ATP binding site [chemical binding]; other site 543734007751 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 543734007752 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 543734007753 active site 543734007754 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 543734007755 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734007756 active site 543734007757 dimer interface [polypeptide binding]; other site 543734007758 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 543734007759 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 543734007760 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 543734007761 Ligand binding site; other site 543734007762 Putative Catalytic site; other site 543734007763 DXD motif; other site 543734007764 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 543734007765 active site 543734007766 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 543734007767 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 543734007768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 543734007769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 543734007770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734007771 dimer interface [polypeptide binding]; other site 543734007772 phosphorylation site [posttranslational modification] 543734007773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734007774 ATP binding site [chemical binding]; other site 543734007775 Mg2+ binding site [ion binding]; other site 543734007776 G-X-G motif; other site 543734007777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734007778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734007779 active site 543734007780 phosphorylation site [posttranslational modification] 543734007781 intermolecular recognition site; other site 543734007782 dimerization interface [polypeptide binding]; other site 543734007783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734007784 DNA binding site [nucleotide binding] 543734007785 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 543734007786 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 543734007787 NAD binding site [chemical binding]; other site 543734007788 sugar binding site [chemical binding]; other site 543734007789 divalent metal binding site [ion binding]; other site 543734007790 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734007791 dimer interface [polypeptide binding]; other site 543734007792 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 543734007793 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734007794 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 543734007795 active site turn [active] 543734007796 phosphorylation site [posttranslational modification] 543734007797 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 543734007798 substrate binding site [chemical binding]; other site 543734007799 catalytic residues [active] 543734007800 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734007801 Helix-turn-helix domains; Region: HTH; cl00088 543734007802 Helix-turn-helix domains; Region: HTH; cl00088 543734007803 Integrase core domain; Region: rve; cl01316 543734007804 hypothetical protein 543734007805 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 543734007806 putative frv operon regulatory protein; Provisional; Region: PRK09863 543734007807 Helix-turn-helix domains; Region: HTH; cl00088 543734007808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734007809 Helix-turn-helix domains; Region: HTH; cl00088 543734007810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 543734007811 Helix-turn-helix domains; Region: HTH; cl00088 543734007812 Helix-turn-helix domains; Region: HTH; cl00088 543734007813 putative transposase OrfB; Reviewed; Region: PHA02517 543734007814 HTH-like domain; Region: HTH_21; pfam13276 543734007815 Integrase core domain; Region: rve; cl01316 543734007816 Integrase core domain; Region: rve_3; cl15866 543734007817 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 543734007818 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 543734007819 putative active site [active] 543734007820 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 543734007821 HPr interaction site; other site 543734007822 glycerol kinase (GK) interaction site [polypeptide binding]; other site 543734007823 active site 543734007824 phosphorylation site [posttranslational modification] 543734007825 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 543734007826 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 543734007827 putative active site [active] 543734007828 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 543734007829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 543734007830 dihydroorotase; Provisional; Region: PRK09237 543734007831 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 543734007832 active site 543734007833 Domain of unknown function (DUF4310); Region: DUF4310; cl11918 543734007834 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 543734007835 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 543734007836 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 543734007837 PRD domain; Region: PRD; cl15445 543734007838 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734007839 Helix-turn-helix domains; Region: HTH; cl00088 543734007840 Helix-turn-helix domains; Region: HTH; cl00088 543734007841 PRD domain; Region: PRD; cl15445 543734007842 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 543734007843 P-loop; other site 543734007844 active site 543734007845 phosphorylation site [posttranslational modification] 543734007846 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734007847 catalytic residue [active] 543734007848 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 543734007849 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 543734007850 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 543734007851 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 543734007852 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 543734007853 Glucitol operon activator protein (GutM); Region: GutM; cl01890 543734007854 Helix-turn-helix domains; Region: HTH; cl00088 543734007855 Helix-turn-helix domains; Region: HTH; cl00088 543734007856 PRD domain; Region: PRD; cl15445 543734007857 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 543734007858 active site 543734007859 phosphorylation site [posttranslational modification] 543734007860 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 543734007861 classical (c) SDRs; Region: SDR_c; cd05233 543734007862 NAD(P) binding site [chemical binding]; other site 543734007863 active site 543734007864 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 543734007865 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 543734007866 intersubunit interface [polypeptide binding]; other site 543734007867 active site 543734007868 Zn2+ binding site [ion binding]; other site 543734007869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734007870 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734007871 active site 543734007872 motif I; other site 543734007873 motif II; other site 543734007874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734007875 motif II; other site 543734007876 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 543734007877 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 543734007878 AP (apurinic/apyrimidinic) site pocket; other site 543734007879 DNA interaction; other site 543734007880 Metal-binding active site; metal-binding site 543734007881 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734007882 Helix-turn-helix domains; Region: HTH; cl00088 543734007883 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734007884 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 543734007885 active site 543734007886 dimer interface [polypeptide binding]; other site 543734007887 magnesium binding site [ion binding]; other site 543734007888 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 543734007889 P-loop; other site 543734007890 active site 543734007891 phosphorylation site [posttranslational modification] 543734007892 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734007893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734007894 active site 543734007895 phosphorylation site [posttranslational modification] 543734007896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734007897 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 543734007898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 543734007899 active site 543734007900 dimer interface [polypeptide binding]; other site 543734007901 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 543734007902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007903 NAD(P) binding site [chemical binding]; other site 543734007904 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 543734007905 catalytic residue [active] 543734007906 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 543734007907 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 543734007908 substrate binding site [chemical binding]; other site 543734007909 hexamer interface [polypeptide binding]; other site 543734007910 metal binding site [ion binding]; metal-binding site 543734007911 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734007912 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734007913 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734007914 active site 543734007915 phosphorylation site [posttranslational modification] 543734007916 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734007917 active pocket/dimerization site; other site 543734007918 active site 543734007919 phosphorylation site [posttranslational modification] 543734007920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007921 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 543734007922 NAD(P) binding site [chemical binding]; other site 543734007923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 543734007924 Helix-turn-helix domains; Region: HTH; cl00088 543734007925 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 543734007926 putative phosphoketolase; Provisional; Region: PRK05261 543734007927 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 543734007928 TPP-binding site; other site 543734007929 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 543734007930 XFP C-terminal domain; Region: XFP_C; pfam09363 543734007931 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 543734007932 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 543734007933 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 543734007934 active site 543734007935 dimer interface [polypeptide binding]; other site 543734007936 catalytic nucleophile [active] 543734007937 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 543734007938 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 543734007939 active site 543734007940 metal binding site [ion binding]; metal-binding site 543734007941 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734007942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734007943 DNA-binding site [nucleotide binding]; DNA binding site 543734007944 UTRA domain; Region: UTRA; cl01230 543734007945 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 543734007946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 543734007947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 543734007948 homodimer interface [polypeptide binding]; other site 543734007949 catalytic residue [active] 543734007950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734007951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734007952 putative substrate translocation pore; other site 543734007953 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 543734007954 D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803 543734007955 N- and C-terminal domain interface [polypeptide binding]; other site 543734007956 D-xylulose kinase; Region: XylB; TIGR01312 543734007957 active site 543734007958 catalytic site [active] 543734007959 metal binding site [ion binding]; metal-binding site 543734007960 xylulose binding site [chemical binding]; other site 543734007961 ATP binding site [chemical binding]; other site 543734007962 homodimer interface [polypeptide binding]; other site 543734007963 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 543734007964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734007965 NAD(P) binding site [chemical binding]; other site 543734007966 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734007967 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734007968 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 543734007969 active site 543734007970 phosphorylation site [posttranslational modification] 543734007971 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734007972 active pocket/dimerization site; other site 543734007973 active site 543734007974 phosphorylation site [posttranslational modification] 543734007975 PRD domain; Region: PRD; cl15445 543734007976 PRD domain; Region: PRD; cl15445 543734007977 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 543734007978 P-loop; other site 543734007979 active site 543734007980 phosphorylation site [posttranslational modification] 543734007981 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734007982 active site 543734007983 phosphorylation site [posttranslational modification] 543734007984 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 543734007985 Helix-turn-helix domains; Region: HTH; cl00088 543734007986 Helix-turn-helix domains; Region: HTH; cl00088 543734007987 Integrase core domain; Region: rve; cl01316 543734007988 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734007989 hypothetical protein; Provisional; Region: PRK08185 543734007990 intersubunit interface [polypeptide binding]; other site 543734007991 active site 543734007992 zinc binding site [ion binding]; other site 543734007993 Na+ binding site [ion binding]; other site 543734007994 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 543734007995 putative N- and C-terminal domain interface [polypeptide binding]; other site 543734007996 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 543734007997 putative active site [active] 543734007998 putative MgATP binding site [chemical binding]; other site 543734007999 catalytic site [active] 543734008000 metal binding site [ion binding]; metal-binding site 543734008001 putative carbohydrate binding site [chemical binding]; other site 543734008002 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 543734008003 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 543734008004 P-loop; other site 543734008005 active site 543734008006 phosphorylation site [posttranslational modification] 543734008007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734008008 active site 543734008009 phosphorylation site [posttranslational modification] 543734008010 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 543734008011 hypothetical protein; Provisional; Region: PRK08185 543734008012 intersubunit interface [polypeptide binding]; other site 543734008013 active site 543734008014 zinc binding site [ion binding]; other site 543734008015 Na+ binding site [ion binding]; other site 543734008016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734008017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734008018 DNA-binding site [nucleotide binding]; DNA binding site 543734008019 UTRA domain; Region: UTRA; cl01230 543734008020 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 543734008021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734008022 Coenzyme A binding pocket [chemical binding]; other site 543734008023 Helix-turn-helix domains; Region: HTH; cl00088 543734008024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008025 D-galactonate transporter; Region: 2A0114; TIGR00893 543734008026 putative substrate translocation pore; other site 543734008027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008028 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734008029 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 543734008030 catalytic triad [active] 543734008031 conserved cis-peptide bond; other site 543734008032 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 543734008033 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 543734008034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734008035 non-specific DNA binding site [nucleotide binding]; other site 543734008036 salt bridge; other site 543734008037 sequence-specific DNA binding site [nucleotide binding]; other site 543734008038 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 543734008039 active site 543734008040 catalytic site [active] 543734008041 Low molecular weight phosphatase family; Region: LMWPc; cd00115 543734008042 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 543734008043 active site 543734008044 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 543734008045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734008046 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 543734008047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008048 dimer interface [polypeptide binding]; other site 543734008049 conserved gate region; other site 543734008050 putative PBP binding loops; other site 543734008051 ABC-ATPase subunit interface; other site 543734008052 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 543734008053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008054 dimer interface [polypeptide binding]; other site 543734008055 conserved gate region; other site 543734008056 putative PBP binding loops; other site 543734008057 ABC-ATPase subunit interface; other site 543734008058 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 543734008059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734008060 Walker A/P-loop; other site 543734008061 ATP binding site [chemical binding]; other site 543734008062 Q-loop/lid; other site 543734008063 ABC transporter signature motif; other site 543734008064 Walker B; other site 543734008065 D-loop; other site 543734008066 H-loop/switch region; other site 543734008067 TOBE domain; Region: TOBE_2; cl01440 543734008068 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 543734008069 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 543734008070 active site 543734008071 Isochorismatase family; Region: Isochorismatase; pfam00857 543734008072 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 543734008073 catalytic triad [active] 543734008074 conserved cis-peptide bond; other site 543734008075 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 543734008076 nudix motif; other site 543734008077 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 543734008078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734008079 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 543734008080 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 543734008081 active site 543734008082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 543734008083 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 543734008084 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 543734008085 putative active site [active] 543734008086 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 543734008087 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 543734008088 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 543734008089 putative active site [active] 543734008090 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 543734008091 active site 543734008092 phosphorylation site [posttranslational modification] 543734008093 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734008094 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734008095 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 543734008096 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 543734008097 DHH family; Region: DHH; pfam01368 543734008098 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 543734008099 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 543734008100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 543734008101 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 543734008102 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734008103 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 543734008104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734008105 Coenzyme A binding pocket [chemical binding]; other site 543734008106 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 543734008107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734008108 active site 543734008109 motif I; other site 543734008110 motif II; other site 543734008111 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 543734008112 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 543734008113 putative NAD(P) binding site [chemical binding]; other site 543734008114 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 543734008115 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 543734008116 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 543734008117 hypothetical protein 543734008118 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 543734008119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734008120 Coenzyme A binding pocket [chemical binding]; other site 543734008121 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734008122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 543734008123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 543734008124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 543734008125 Coenzyme A binding pocket [chemical binding]; other site 543734008126 Divergent AAA domain; Region: AAA_4; pfam04326 543734008127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 543734008128 Integrase core domain; Region: rve; cl01316 543734008129 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 543734008130 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 543734008131 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 543734008132 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 543734008133 transmembrane helices; other site 543734008134 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 543734008135 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 543734008136 metal binding site [ion binding]; metal-binding site 543734008137 dimer interface [polypeptide binding]; other site 543734008138 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 543734008139 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 543734008140 peptide binding site [polypeptide binding]; other site 543734008141 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 543734008142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 543734008143 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734008144 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 543734008145 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 543734008146 putative dimer interface [polypeptide binding]; other site 543734008147 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 543734008148 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 543734008149 protein binding site [polypeptide binding]; other site 543734008150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 543734008151 YycH protein; Region: YycI; cl02015 543734008152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 543734008153 YycH protein; Region: YycH; pfam07435 543734008154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 543734008155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 543734008156 dimerization interface [polypeptide binding]; other site 543734008157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 543734008158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 543734008159 dimer interface [polypeptide binding]; other site 543734008160 phosphorylation site [posttranslational modification] 543734008161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 543734008162 ATP binding site [chemical binding]; other site 543734008163 Mg2+ binding site [ion binding]; other site 543734008164 G-X-G motif; other site 543734008165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 543734008166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734008167 active site 543734008168 phosphorylation site [posttranslational modification] 543734008169 intermolecular recognition site; other site 543734008170 dimerization interface [polypeptide binding]; other site 543734008171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 543734008172 DNA binding site [nucleotide binding] 543734008173 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734008174 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 543734008175 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734008176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734008177 substrate binding pocket [chemical binding]; other site 543734008178 membrane-bound complex binding site; other site 543734008179 hinge residues; other site 543734008180 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734008181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008182 dimer interface [polypeptide binding]; other site 543734008183 conserved gate region; other site 543734008184 putative PBP binding loops; other site 543734008185 ABC-ATPase subunit interface; other site 543734008186 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 543734008187 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 543734008188 ANP binding site [chemical binding]; other site 543734008189 Substrate Binding Site II [chemical binding]; other site 543734008190 Substrate Binding Site I [chemical binding]; other site 543734008191 argininosuccinate lyase; Provisional; Region: PRK00855 543734008192 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 543734008193 active sites [active] 543734008194 tetramer interface [polypeptide binding]; other site 543734008195 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 543734008196 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 543734008197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734008198 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 543734008199 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 543734008200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 543734008201 DNA-binding site [nucleotide binding]; DNA binding site 543734008202 UTRA domain; Region: UTRA; cl01230 543734008203 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 543734008204 active site 543734008205 P-loop; other site 543734008206 phosphorylation site [posttranslational modification] 543734008207 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 543734008208 active site 543734008209 methionine cluster; other site 543734008210 phosphorylation site [posttranslational modification] 543734008211 metal binding site [ion binding]; metal-binding site 543734008212 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 543734008213 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734008214 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 543734008215 nudix motif; other site 543734008216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734008217 Isochorismatase family; Region: Isochorismatase; pfam00857 543734008218 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 543734008219 catalytic triad [active] 543734008220 dimer interface [polypeptide binding]; other site 543734008221 conserved cis-peptide bond; other site 543734008222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 543734008224 putative substrate translocation pore; other site 543734008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008226 cyanate transporter; Region: CynX; TIGR00896 543734008227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008228 putative substrate translocation pore; other site 543734008229 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 543734008230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 543734008231 active site 543734008232 catalytic tetrad [active] 543734008233 Domain of unknown function (DUF956); Region: DUF956; cl01917 543734008234 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 543734008235 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 543734008236 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 543734008237 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 543734008238 active pocket/dimerization site; other site 543734008239 active site 543734008240 phosphorylation site [posttranslational modification] 543734008241 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 543734008242 active site 543734008243 phosphorylation site [posttranslational modification] 543734008244 H+ Antiporter protein; Region: 2A0121; TIGR00900 543734008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 543734008246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734008247 non-specific DNA binding site [nucleotide binding]; other site 543734008248 salt bridge; other site 543734008249 sequence-specific DNA binding site [nucleotide binding]; other site 543734008250 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 543734008251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734008252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 543734008253 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 543734008254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734008255 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734008256 substrate binding pocket [chemical binding]; other site 543734008257 membrane-bound complex binding site; other site 543734008258 hinge residues; other site 543734008259 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 543734008260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008261 dimer interface [polypeptide binding]; other site 543734008262 conserved gate region; other site 543734008263 putative PBP binding loops; other site 543734008264 ABC-ATPase subunit interface; other site 543734008265 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 543734008266 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 543734008267 Walker A/P-loop; other site 543734008268 ATP binding site [chemical binding]; other site 543734008269 Q-loop/lid; other site 543734008270 ABC transporter signature motif; other site 543734008271 Walker B; other site 543734008272 D-loop; other site 543734008273 H-loop/switch region; other site 543734008274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 543734008275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 543734008276 Protein of unknown function (DUF975); Region: DUF975; cl10504 543734008277 Bacterial PH domain; Region: DUF304; cl01348 543734008278 Predicted membrane protein [Function unknown]; Region: COG3428 543734008279 Bacterial PH domain; Region: DUF304; cl01348 543734008280 Bacterial PH domain; Region: DUF304; cl01348 543734008281 Bacterial PH domain; Region: DUF304; cl01348 543734008282 Predicted ATPase [General function prediction only]; Region: COG3910 543734008283 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 543734008284 Walker A/P-loop; other site 543734008285 ATP binding site [chemical binding]; other site 543734008286 Q-loop/lid; other site 543734008287 ABC transporter signature motif; other site 543734008288 Walker B; other site 543734008289 D-loop; other site 543734008290 H-loop/switch region; other site 543734008291 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 543734008292 Phosphotransferase enzyme family; Region: APH; pfam01636 543734008293 active site 543734008294 ATP binding site [chemical binding]; other site 543734008295 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 543734008296 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 543734008297 Walker A/P-loop; other site 543734008298 ATP binding site [chemical binding]; other site 543734008299 Q-loop/lid; other site 543734008300 ABC transporter signature motif; other site 543734008301 Walker B; other site 543734008302 D-loop; other site 543734008303 H-loop/switch region; other site 543734008304 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734008305 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734008306 substrate binding pocket [chemical binding]; other site 543734008307 membrane-bound complex binding site; other site 543734008308 hinge residues; other site 543734008309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008310 dimer interface [polypeptide binding]; other site 543734008311 conserved gate region; other site 543734008312 putative PBP binding loops; other site 543734008313 ABC-ATPase subunit interface; other site 543734008314 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 543734008315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 543734008316 substrate binding pocket [chemical binding]; other site 543734008317 membrane-bound complex binding site; other site 543734008318 hinge residues; other site 543734008319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 543734008320 dimer interface [polypeptide binding]; other site 543734008321 conserved gate region; other site 543734008322 putative PBP binding loops; other site 543734008323 ABC-ATPase subunit interface; other site 543734008324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 543734008325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 543734008326 Integral membrane protein DUF95; Region: DUF95; cl00572 543734008327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 543734008328 Walker A motif; other site 543734008329 ATP binding site [chemical binding]; other site 543734008330 Walker B motif; other site 543734008331 MoxR-like ATPases [General function prediction only]; Region: COG0714 543734008332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 543734008333 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 543734008334 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 543734008335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 543734008336 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 543734008337 putative ADP-binding pocket [chemical binding]; other site 543734008338 maltose O-acetyltransferase; Provisional; Region: PRK10092 543734008339 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 543734008340 active site 543734008341 substrate binding site [chemical binding]; other site 543734008342 trimer interface [polypeptide binding]; other site 543734008343 CoA binding site [chemical binding]; other site 543734008344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734008345 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734008346 active site 543734008347 motif I; other site 543734008348 motif II; other site 543734008349 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734008350 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 543734008351 Aspartase; Region: Aspartase; cd01357 543734008352 active sites [active] 543734008353 tetramer interface [polypeptide binding]; other site 543734008354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 543734008355 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 543734008356 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 543734008357 Malic enzyme, N-terminal domain; Region: malic; pfam00390 543734008358 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 543734008359 putative NAD(P) binding site [chemical binding]; other site 543734008360 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 543734008361 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 543734008362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 543734008363 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 543734008364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 543734008365 active site 543734008366 phosphorylation site [posttranslational modification] 543734008367 intermolecular recognition site; other site 543734008368 dimerization interface [polypeptide binding]; other site 543734008369 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 543734008370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734008371 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 543734008372 amino acid transporter; Region: 2A0306; TIGR00909 543734008373 amino acid transporter; Region: 2A0306; TIGR00909 543734008374 glycogen synthase; Provisional; Region: glgA; PRK00654 543734008375 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 543734008376 Int/Topo IB signature motif; other site 543734008377 hypothetical protein; Provisional; Region: PRK04140 543734008378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 543734008379 non-specific DNA binding site [nucleotide binding]; other site 543734008380 salt bridge; other site 543734008381 sequence-specific DNA binding site [nucleotide binding]; other site 543734008382 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 543734008383 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 543734008384 polymerase nucleotide-binding site; other site 543734008385 DNA-binding residues [nucleotide binding]; DNA binding site 543734008386 nucleotide binding site [chemical binding]; other site 543734008387 primase nucleotide-binding site [nucleotide binding]; other site 543734008388 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 543734008389 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 543734008390 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 543734008391 Phage terminase, small subunit; Region: Terminase_4; cl01525 543734008392 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 543734008393 Phage Terminase; Region: Terminase_1; pfam03354 543734008394 Phage portal protein; Region: Phage_portal; pfam04860 543734008395 Phage-related protein [Function unknown]; Region: COG4695; cl01923 543734008396 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 543734008397 Phage capsid family; Region: Phage_capsid; pfam05065 543734008398 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 543734008399 oligomerization interface [polypeptide binding]; other site 543734008400 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 543734008401 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 543734008402 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 543734008403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 543734008404 active site 543734008405 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734008406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 543734008407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 543734008408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 543734008409 substrate binding pocket [chemical binding]; other site 543734008410 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 543734008411 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 543734008412 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 543734008413 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 543734008414 active site 543734008415 phosphorylation site [posttranslational modification] 543734008416 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 543734008417 Helix-turn-helix domains; Region: HTH; cl00088 543734008418 PRD domain; Region: PRD; cl15445 543734008419 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 543734008420 P-loop; other site 543734008421 active site 543734008422 phosphorylation site [posttranslational modification] 543734008423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 543734008424 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 543734008425 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 543734008426 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 543734008427 active site 543734008428 P-loop; other site 543734008429 phosphorylation site [posttranslational modification] 543734008430 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 543734008431 active site 543734008432 P-loop; other site 543734008433 phosphorylation site [posttranslational modification] 543734008434 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 543734008435 active site 543734008436 trimer interface [polypeptide binding]; other site 543734008437 allosteric site; other site 543734008438 active site lid [active] 543734008439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 543734008440 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 543734008441 active site 543734008442 motif I; other site 543734008443 motif II; other site 543734008444 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 543734008445 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 543734008446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 543734008447 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 543734008448 Walker A/P-loop; other site 543734008449 ATP binding site [chemical binding]; other site 543734008450 Q-loop/lid; other site 543734008451 ABC transporter signature motif; other site 543734008452 Walker B; other site 543734008453 D-loop; other site 543734008454 H-loop/switch region; other site 543734008455 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 543734008456 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 543734008457 FtsX-like permease family; Region: FtsX; cl15850 543734008458 Gram positive anchor; Region: Gram_pos_anchor; cl15427 543734008459 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 543734008460 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 543734008461 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 543734008462 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 543734008463 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 543734008464 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 543734008465 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 543734008466 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 543734008467 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 543734008468 putative active site [active] 543734008469 metal binding site [ion binding]; metal-binding site 543734008470 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 543734008471 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 543734008472 metal binding site [ion binding]; metal-binding site 543734008473 dimer interface [polypeptide binding]; other site 543734008474 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734008475 Uncharacterized conserved protein [Function unknown]; Region: COG2966 543734008476 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 543734008477 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 543734008478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 543734008479 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 543734008480 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 543734008481 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 543734008482 trmE is a tRNA modification GTPase; Region: trmE; cd04164 543734008483 G1 box; other site 543734008484 GTP/Mg2+ binding site [chemical binding]; other site 543734008485 Switch I region; other site 543734008486 G2 box; other site 543734008487 Switch II region; other site 543734008488 G3 box; other site 543734008489 G4 box; other site 543734008490 G5 box; other site 543734008491 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 543734008492 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 543734008493 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 543734008494 G-X-X-G motif; other site 543734008495 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 543734008496 RxxxH motif; other site 543734008497 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 543734008498 Ribonuclease P; Region: Ribonuclease_P; cl00457 543734008499 Ribosomal protein L34; Region: Ribosomal_L34; cl00370