-- dump date 20120504_151141 -- class Genbank::misc_feature -- table misc_feature_note -- id note 633699000001 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 633699000002 Replication initiation factor; Region: Rep_trans; pfam02486 633699000003 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 633699000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000005 Walker A motif; other site 633699000006 ATP binding site [chemical binding]; other site 633699000007 Walker B motif; other site 633699000008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699000009 arginine finger; other site 633699000010 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 633699000011 DnaA box-binding interface [nucleotide binding]; other site 633699000012 DNA polymerase III subunit beta; Validated; Region: PRK05643 633699000013 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633699000014 putative DNA binding surface [nucleotide binding]; other site 633699000015 dimer interface [polypeptide binding]; other site 633699000016 beta-clamp/clamp loader binding surface; other site 633699000017 beta-clamp/translesion DNA polymerase binding surface; other site 633699000018 recombination protein F; Reviewed; Region: recF; PRK00064 633699000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 633699000020 Walker A/P-loop; other site 633699000021 ATP binding site [chemical binding]; other site 633699000022 Q-loop/lid; other site 633699000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699000024 ABC transporter signature motif; other site 633699000025 Walker B; other site 633699000026 D-loop; other site 633699000027 H-loop/switch region; other site 633699000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 633699000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699000030 Mg2+ binding site [ion binding]; other site 633699000031 G-X-G motif; other site 633699000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633699000033 anchoring element; other site 633699000034 dimer interface [polypeptide binding]; other site 633699000035 ATP binding site [chemical binding]; other site 633699000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633699000037 active site 633699000038 putative metal-binding site [ion binding]; other site 633699000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633699000040 DNA gyrase subunit A; Validated; Region: PRK05560 633699000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 633699000042 CAP-like domain; other site 633699000043 active site 633699000044 primary dimer interface [polypeptide binding]; other site 633699000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699000051 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 633699000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633699000053 dimer interface [polypeptide binding]; other site 633699000054 ssDNA binding site [nucleotide binding]; other site 633699000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699000056 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 633699000057 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 633699000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 633699000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 633699000060 DHH family; Region: DHH; pfam01368 633699000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 633699000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 633699000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 633699000064 replicative DNA helicase; Region: DnaB; TIGR00665 633699000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 633699000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 633699000067 Walker A motif; other site 633699000068 ATP binding site [chemical binding]; other site 633699000069 Walker B motif; other site 633699000070 DNA binding loops [nucleotide binding] 633699000071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699000072 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 633699000073 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 633699000074 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 633699000075 Spore germination protein; Region: Spore_permease; cl15802 633699000076 L-type amino acid transporter; Region: 2A0308; TIGR00911 633699000077 Transposase, Mutator family; Region: Transposase_mut; pfam00872 633699000078 Bacterial surface layer protein; Region: SLAP; pfam03217 633699000079 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 633699000080 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 633699000081 Gram positive anchor; Region: Gram_pos_anchor; cl15427 633699000082 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 633699000083 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 633699000084 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699000085 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699000086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000087 NAD(P) binding site [chemical binding]; other site 633699000088 active site 633699000089 Protein of unknown function (DUF975); Region: DUF975; cl10504 633699000090 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 633699000091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699000092 motif II; other site 633699000093 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 633699000094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699000095 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699000096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699000097 Walker A/P-loop; other site 633699000098 ATP binding site [chemical binding]; other site 633699000099 Q-loop/lid; other site 633699000100 ABC transporter signature motif; other site 633699000101 Walker B; other site 633699000102 D-loop; other site 633699000103 H-loop/switch region; other site 633699000104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633699000105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 633699000106 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 633699000107 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 633699000108 G1 box; other site 633699000109 putative GEF interaction site [polypeptide binding]; other site 633699000110 GTP/Mg2+ binding site [chemical binding]; other site 633699000111 Switch I region; other site 633699000112 G2 box; other site 633699000113 G3 box; other site 633699000114 Switch II region; other site 633699000115 G4 box; other site 633699000116 G5 box; other site 633699000117 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 633699000118 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 633699000119 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 633699000120 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 633699000121 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 633699000122 Cl- selectivity filter; other site 633699000123 Cl- binding residues [ion binding]; other site 633699000124 pore gating glutamate residue; other site 633699000125 dimer interface [polypeptide binding]; other site 633699000126 H+/Cl- coupling transport residue; other site 633699000127 H+ Antiporter protein; Region: 2A0121; TIGR00900 633699000128 CsbD-like; Region: CsbD; cl15799 633699000129 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 633699000130 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 633699000131 active site 633699000132 putative catalytic site [active] 633699000133 DNA binding site [nucleotide binding] 633699000134 putative phosphate binding site [ion binding]; other site 633699000135 metal binding site A [ion binding]; metal-binding site 633699000136 AP binding site [nucleotide binding]; other site 633699000137 metal binding site B [ion binding]; metal-binding site 633699000138 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 633699000139 PLD-like domain; Region: PLDc_2; pfam13091 633699000140 putative homodimer interface [polypeptide binding]; other site 633699000141 putative active site [active] 633699000142 catalytic site [active] 633699000143 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699000144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000145 ATP binding site [chemical binding]; other site 633699000146 putative Mg++ binding site [ion binding]; other site 633699000147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000148 nucleotide binding region [chemical binding]; other site 633699000149 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 633699000150 ATP-binding site [chemical binding]; other site 633699000151 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 633699000152 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699000153 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 633699000154 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633699000155 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 633699000156 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 633699000157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699000158 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 633699000159 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 633699000160 active site 633699000161 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 633699000162 active site 633699000163 catalytic triad [active] 633699000164 oxyanion hole [active] 633699000165 D-lactate dehydrogenase; Validated; Region: PRK08605 633699000166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000167 MucBP domain; Region: MucBP; pfam06458 633699000168 MucBP domain; Region: MucBP; pfam06458 633699000169 MucBP domain; Region: MucBP; pfam06458 633699000170 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 633699000171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699000172 Helix-turn-helix domains; Region: HTH; cl00088 633699000173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699000174 dimerization interface [polypeptide binding]; other site 633699000175 FMN-binding domain; Region: FMN_bind; cl01081 633699000176 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 633699000177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000178 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 633699000179 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 633699000180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699000181 S-adenosylmethionine binding site [chemical binding]; other site 633699000182 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 633699000183 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 633699000184 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 633699000185 active site 633699000186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699000187 putative substrate translocation pore; other site 633699000188 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 633699000189 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699000190 putative acyl-acceptor binding pocket; other site 633699000191 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699000192 putative acyl-acceptor binding pocket; other site 633699000193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699000194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699000195 active site 633699000196 phosphorylation site [posttranslational modification] 633699000197 intermolecular recognition site; other site 633699000198 dimerization interface [polypeptide binding]; other site 633699000199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699000200 DNA binding site [nucleotide binding] 633699000201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 633699000202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633699000203 dimerization interface [polypeptide binding]; other site 633699000204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633699000205 putative active site [active] 633699000206 heme pocket [chemical binding]; other site 633699000207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699000208 dimer interface [polypeptide binding]; other site 633699000209 phosphorylation site [posttranslational modification] 633699000210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699000211 ATP binding site [chemical binding]; other site 633699000212 Mg2+ binding site [ion binding]; other site 633699000213 G-X-G motif; other site 633699000214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 633699000215 YycH protein; Region: YycH; pfam07435 633699000216 YycH protein; Region: YycI; cl02015 633699000217 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699000218 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 633699000219 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 633699000220 protein binding site [polypeptide binding]; other site 633699000221 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 633699000222 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 633699000223 Cobalt transport protein; Region: CbiQ; cl00463 633699000224 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699000225 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000226 Walker A/P-loop; other site 633699000227 ATP binding site [chemical binding]; other site 633699000228 Q-loop/lid; other site 633699000229 ABC transporter signature motif; other site 633699000230 Walker B; other site 633699000231 D-loop; other site 633699000232 H-loop/switch region; other site 633699000233 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000234 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 633699000235 Walker A/P-loop; other site 633699000236 ATP binding site [chemical binding]; other site 633699000237 Q-loop/lid; other site 633699000238 ABC transporter signature motif; other site 633699000239 Walker B; other site 633699000240 D-loop; other site 633699000241 H-loop/switch region; other site 633699000242 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 633699000243 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 633699000244 Peptidase family M48; Region: Peptidase_M48; cl12018 633699000245 LemA family; Region: LemA; cl00742 633699000246 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 633699000247 transmembrane helices; other site 633699000248 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 633699000249 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 633699000250 DXD motif; other site 633699000251 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 633699000252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699000253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699000254 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 633699000255 active site 633699000256 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 633699000257 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699000258 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 633699000259 Walker A/P-loop; other site 633699000260 ATP binding site [chemical binding]; other site 633699000261 Q-loop/lid; other site 633699000262 ABC transporter signature motif; other site 633699000263 Walker B; other site 633699000264 D-loop; other site 633699000265 H-loop/switch region; other site 633699000266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699000267 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699000268 substrate binding pocket [chemical binding]; other site 633699000269 membrane-bound complex binding site; other site 633699000270 hinge residues; other site 633699000271 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699000272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000273 dimer interface [polypeptide binding]; other site 633699000274 conserved gate region; other site 633699000275 putative PBP binding loops; other site 633699000276 ABC-ATPase subunit interface; other site 633699000277 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 633699000278 active site 633699000279 DNA binding site [nucleotide binding] 633699000280 Protein of unknown function, DUF488; Region: DUF488; cl01246 633699000281 Integral membrane protein TerC family; Region: TerC; cl10468 633699000282 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 633699000283 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 633699000284 DNA binding site [nucleotide binding] 633699000285 active site 633699000286 NAD-dependent deacetylase; Provisional; Region: PRK00481 633699000287 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 633699000288 NAD+ binding site [chemical binding]; other site 633699000289 substrate binding site [chemical binding]; other site 633699000290 putative Zn binding site [ion binding]; other site 633699000291 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 633699000292 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 633699000293 putative active site [active] 633699000294 catalytic site [active] 633699000295 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 633699000296 putative active site [active] 633699000297 catalytic site [active] 633699000298 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 633699000299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699000300 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 633699000301 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 633699000302 RNA/DNA hybrid binding site [nucleotide binding]; other site 633699000303 active site 633699000304 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 633699000305 putative glycosyl transferase; Provisional; Region: PRK10073 633699000306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699000307 active site 633699000308 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699000309 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633699000310 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633699000311 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633699000312 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 633699000313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699000314 Helix-turn-helix domains; Region: HTH; cl00088 633699000315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699000316 Transposase domain (DUF772); Region: DUF772; cl15789 633699000317 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 633699000318 MatE; Region: MatE; cl10513 633699000319 MatE; Region: MatE; cl10513 633699000320 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 633699000321 MatE; Region: MatE; cl10513 633699000322 MatE; Region: MatE; cl10513 633699000323 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 633699000324 catalytic site [active] 633699000325 metal binding site [ion binding]; metal-binding site 633699000326 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699000327 Transposase domain (DUF772); Region: DUF772; cl15789 633699000328 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 633699000329 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 633699000330 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 633699000331 ATP-grasp domain; Region: ATP-grasp_4; cl03087 633699000332 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633699000333 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 633699000334 YibE/F-like protein; Region: YibE_F; cl02259 633699000335 YibE/F-like protein; Region: YibE_F; cl02259 633699000336 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 633699000337 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699000338 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 633699000339 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 633699000340 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 633699000341 active site 633699000342 catalytic site [active] 633699000343 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 633699000344 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 633699000345 Interdomain contacts; other site 633699000346 Cytokine receptor motif; other site 633699000347 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 633699000348 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000350 DNA-binding site [nucleotide binding]; DNA binding site 633699000351 UTRA domain; Region: UTRA; cl01230 633699000352 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 633699000353 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633699000354 dimer interface [polypeptide binding]; other site 633699000355 active site 633699000356 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 633699000357 putative active site [active] 633699000358 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 633699000359 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 633699000360 active site 633699000361 dimer interface [polypeptide binding]; other site 633699000362 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 633699000363 active site 633699000364 phosphorylation site [posttranslational modification] 633699000365 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 633699000366 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 633699000367 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699000368 active pocket/dimerization site; other site 633699000369 active site 633699000370 phosphorylation site [posttranslational modification] 633699000371 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 633699000372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699000373 Helix-turn-helix domains; Region: HTH; cl00088 633699000374 Helix-turn-helix domains; Region: HTH; cl00088 633699000375 HTH-like domain; Region: HTH_21; pfam13276 633699000376 Integrase core domain; Region: rve; cl01316 633699000377 Integrase core domain; Region: rve_3; cl15866 633699000378 TIR domain; Region: TIR_2; cl15770 633699000379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699000380 active site 633699000381 phosphorylation site [posttranslational modification] 633699000382 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000384 DNA-binding site [nucleotide binding]; DNA binding site 633699000385 UTRA domain; Region: UTRA; cl01230 633699000386 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 633699000387 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 633699000388 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699000389 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633699000390 Ligand Binding Site [chemical binding]; other site 633699000391 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 633699000392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 633699000393 membrane-bound complex binding site; other site 633699000394 hinge residues; other site 633699000395 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 633699000396 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 633699000397 Walker A/P-loop; other site 633699000398 ATP binding site [chemical binding]; other site 633699000399 Q-loop/lid; other site 633699000400 ABC transporter signature motif; other site 633699000401 Walker B; other site 633699000402 D-loop; other site 633699000403 H-loop/switch region; other site 633699000404 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 633699000405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 633699000406 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 633699000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000408 dimer interface [polypeptide binding]; other site 633699000409 conserved gate region; other site 633699000410 putative PBP binding loops; other site 633699000411 ABC-ATPase subunit interface; other site 633699000412 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 633699000413 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 633699000414 active site 633699000415 dimer interface [polypeptide binding]; other site 633699000416 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 633699000417 Ligand Binding Site [chemical binding]; other site 633699000418 Molecular Tunnel; other site 633699000419 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 633699000420 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 633699000421 ATP-grasp domain; Region: ATP-grasp_4; cl03087 633699000422 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 633699000423 ATP cone domain; Region: ATP-cone; pfam03477 633699000424 Class III ribonucleotide reductase; Region: RNR_III; cd01675 633699000425 effector binding site; other site 633699000426 active site 633699000427 Zn binding site [ion binding]; other site 633699000428 glycine loop; other site 633699000429 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 633699000430 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 633699000431 Domain of unknown function DUF59; Region: DUF59; cl00941 633699000432 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 633699000433 Uncharacterized conserved protein [Function unknown]; Region: COG2461 633699000434 Family of unknown function (DUF438); Region: DUF438; pfam04282 633699000435 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 633699000436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699000437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699000438 putative substrate translocation pore; other site 633699000439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 633699000440 hypothetical protein; Provisional; Region: PRK11281 633699000441 cell division protein MukB; Provisional; Region: mukB; PRK04863 633699000442 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699000443 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699000444 putative active site [active] 633699000445 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699000446 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699000447 putative substrate binding site [chemical binding]; other site 633699000448 putative ATP binding site [chemical binding]; other site 633699000449 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 633699000450 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 633699000451 active site 633699000452 P-loop; other site 633699000453 phosphorylation site [posttranslational modification] 633699000454 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699000455 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699000456 active site 633699000457 phosphorylation site [posttranslational modification] 633699000458 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 633699000459 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 633699000460 active site 633699000461 Zn binding site [ion binding]; other site 633699000462 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 633699000463 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 633699000464 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 633699000465 active site 633699000466 metal-binding site [ion binding] 633699000467 nucleotide-binding site [chemical binding]; other site 633699000468 K+ potassium transporter; Region: K_trans; cl15781 633699000469 K+ potassium transporter; Region: K_trans; cl15781 633699000470 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 633699000471 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 633699000472 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 633699000473 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 633699000474 active site 633699000475 Bacterial SH3 domain; Region: SH3_3; cl02551 633699000476 Bacterial SH3 domain; Region: SH3_3; cl02551 633699000477 Bacterial SH3 domain; Region: SH3_3; cl02551 633699000478 Bacterial SH3 domain; Region: SH3_3; cl02551 633699000479 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699000480 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699000481 putative substrate binding site [chemical binding]; other site 633699000482 putative ATP binding site [chemical binding]; other site 633699000483 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 633699000484 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 633699000485 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 633699000486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000487 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 633699000488 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633699000489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000490 PAS domain; Region: PAS_10; pfam13596 633699000491 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699000492 catalytic core [active] 633699000493 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699000494 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 633699000495 GtrA-like protein; Region: GtrA; cl00971 633699000496 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 633699000497 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 633699000498 Ligand binding site; other site 633699000499 Putative Catalytic site; other site 633699000500 DXD motif; other site 633699000501 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699000502 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699000503 Sugar transport protein; Region: Sugar_transport; pfam06800 633699000504 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 633699000505 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 633699000506 active site 633699000507 catalytic residues [active] 633699000508 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699000509 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 633699000510 Sulfatase; Region: Sulfatase; cl10460 633699000511 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 633699000512 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 633699000513 active site 633699000514 HIGH motif; other site 633699000515 dimer interface [polypeptide binding]; other site 633699000516 KMSKS motif; other site 633699000517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699000518 RNA binding surface [nucleotide binding]; other site 633699000519 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699000520 trimer interface [polypeptide binding]; other site 633699000521 active site 633699000522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699000523 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699000524 trimer interface [polypeptide binding]; other site 633699000525 active site 633699000526 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633699000527 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633699000528 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633699000529 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 633699000530 putative dimer interface [polypeptide binding]; other site 633699000531 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699000532 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699000533 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699000534 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000536 DNA-binding site [nucleotide binding]; DNA binding site 633699000537 UTRA domain; Region: UTRA; cl01230 633699000538 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 633699000539 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699000540 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699000541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699000542 DNA-binding site [nucleotide binding]; DNA binding site 633699000543 UTRA domain; Region: UTRA; cl01230 633699000544 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 633699000545 methionine cluster; other site 633699000546 active site 633699000547 phosphorylation site [posttranslational modification] 633699000548 metal binding site [ion binding]; metal-binding site 633699000549 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 633699000550 active site 633699000551 P-loop; other site 633699000552 phosphorylation site [posttranslational modification] 633699000553 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699000554 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699000555 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699000556 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699000557 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 633699000558 CAAX protease self-immunity; Region: Abi; cl00558 633699000559 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 633699000560 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 633699000561 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 633699000562 active site 633699000563 HIGH motif; other site 633699000564 dimer interface [polypeptide binding]; other site 633699000565 KMSKS motif; other site 633699000566 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 633699000567 catalytic motif [active] 633699000568 Zn binding site [ion binding]; other site 633699000569 Repair protein; Region: Repair_PSII; cl01535 633699000570 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699000571 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699000572 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 633699000573 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 633699000574 active site 633699000575 HIGH motif; other site 633699000576 KMSKS motif; other site 633699000577 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 633699000578 tRNA binding surface [nucleotide binding]; other site 633699000579 anticodon binding site; other site 633699000580 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 633699000581 dimer interface [polypeptide binding]; other site 633699000582 putative tRNA-binding site [nucleotide binding]; other site 633699000583 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 633699000584 active site 633699000585 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 633699000586 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 633699000587 putative active site [active] 633699000588 putative metal binding site [ion binding]; other site 633699000589 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 633699000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000591 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 633699000592 pur operon repressor; Provisional; Region: PRK09213 633699000593 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 633699000594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699000595 active site 633699000596 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 633699000597 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 633699000598 Substrate binding site; other site 633699000599 Mg++ binding site; other site 633699000600 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 633699000601 active site 633699000602 substrate binding site [chemical binding]; other site 633699000603 CoA binding site [chemical binding]; other site 633699000604 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633699000605 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633699000606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699000607 active site 633699000608 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699000609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699000610 DNA binding site [nucleotide binding] 633699000611 domain linker motif; other site 633699000612 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 633699000613 ligand binding site [chemical binding]; other site 633699000614 dimerization interface [polypeptide binding]; other site 633699000615 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699000616 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699000617 Ca binding site [ion binding]; other site 633699000618 active site 633699000619 catalytic site [active] 633699000620 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 633699000621 homodimer interface [polypeptide binding]; other site 633699000622 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 633699000623 active site 633699000624 homodimer interface [polypeptide binding]; other site 633699000625 catalytic site [active] 633699000626 maltose phosphorylase; Provisional; Region: PRK13807 633699000627 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 633699000628 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 633699000629 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 633699000630 beta-phosphoglucomutase; Region: bPGM; TIGR01990 633699000631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699000632 motif II; other site 633699000633 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 633699000634 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 633699000635 Walker A/P-loop; other site 633699000636 ATP binding site [chemical binding]; other site 633699000637 Q-loop/lid; other site 633699000638 ABC transporter signature motif; other site 633699000639 Walker B; other site 633699000640 D-loop; other site 633699000641 H-loop/switch region; other site 633699000642 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 633699000643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699000644 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 633699000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000646 dimer interface [polypeptide binding]; other site 633699000647 conserved gate region; other site 633699000648 putative PBP binding loops; other site 633699000649 ABC-ATPase subunit interface; other site 633699000650 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 633699000651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699000652 dimer interface [polypeptide binding]; other site 633699000653 conserved gate region; other site 633699000654 putative PBP binding loops; other site 633699000655 ABC-ATPase subunit interface; other site 633699000656 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699000657 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699000658 Ca binding site [ion binding]; other site 633699000659 active site 633699000660 catalytic site [active] 633699000661 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 633699000662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699000663 Zn2+ binding site [ion binding]; other site 633699000664 Mg2+ binding site [ion binding]; other site 633699000665 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 633699000666 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 633699000667 CTP synthetase; Validated; Region: pyrG; PRK05380 633699000668 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 633699000669 Catalytic site [active] 633699000670 active site 633699000671 UTP binding site [chemical binding]; other site 633699000672 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 633699000673 active site 633699000674 putative oxyanion hole; other site 633699000675 catalytic triad [active] 633699000676 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 633699000677 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 633699000678 hinge; other site 633699000679 active site 633699000680 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 633699000681 xanthine permease; Region: pbuX; TIGR03173 633699000682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 633699000683 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 633699000684 GMP synthase; Reviewed; Region: guaA; PRK00074 633699000685 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 633699000686 AMP/PPi binding site [chemical binding]; other site 633699000687 candidate oxyanion hole; other site 633699000688 catalytic triad [active] 633699000689 potential glutamine specificity residues [chemical binding]; other site 633699000690 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 633699000691 ATP Binding subdomain [chemical binding]; other site 633699000692 Ligand Binding sites [chemical binding]; other site 633699000693 Dimerization subdomain; other site 633699000694 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 633699000695 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 633699000696 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 633699000697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 633699000700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000701 ATP binding site [chemical binding]; other site 633699000702 putative Mg++ binding site [ion binding]; other site 633699000703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699000704 Helix-turn-helix domains; Region: HTH; cl00088 633699000705 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 633699000706 substrate binding site [chemical binding]; other site 633699000707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699000708 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699000709 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699000710 Helix-turn-helix domains; Region: HTH; cl00088 633699000711 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 633699000712 dimer interface [polypeptide binding]; other site 633699000713 FMN binding site [chemical binding]; other site 633699000714 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 633699000715 dimer interface [polypeptide binding]; other site 633699000716 FMN binding site [chemical binding]; other site 633699000717 NADPH bind site [chemical binding]; other site 633699000718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699000719 Helix-turn-helix domains; Region: HTH; cl00088 633699000720 Helix-turn-helix domains; Region: HTH; cl00088 633699000721 HTH-like domain; Region: HTH_21; pfam13276 633699000722 Integrase core domain; Region: rve; cl01316 633699000723 Integrase core domain; Region: rve_3; cl15866 633699000724 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 633699000725 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699000726 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 633699000727 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 633699000728 dimer interface [polypeptide binding]; other site 633699000729 active site 633699000730 glycine-pyridoxal phosphate binding site [chemical binding]; other site 633699000731 folate binding site [chemical binding]; other site 633699000732 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 633699000733 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 633699000734 zinc binding site [ion binding]; other site 633699000735 putative ligand binding site [chemical binding]; other site 633699000736 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 633699000737 TM-ABC transporter signature motif; other site 633699000738 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 633699000739 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 633699000740 Walker A/P-loop; other site 633699000741 ATP binding site [chemical binding]; other site 633699000742 Q-loop/lid; other site 633699000743 ABC transporter signature motif; other site 633699000744 Walker B; other site 633699000745 D-loop; other site 633699000746 H-loop/switch region; other site 633699000747 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 633699000748 Spore germination protein; Region: Spore_permease; cl15802 633699000749 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 633699000750 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 633699000751 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699000752 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699000753 helicase 45; Provisional; Region: PTZ00424 633699000754 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 633699000755 ATP binding site [chemical binding]; other site 633699000756 Mg++ binding site [ion binding]; other site 633699000757 motif III; other site 633699000758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000759 nucleotide binding region [chemical binding]; other site 633699000760 ATP-binding site [chemical binding]; other site 633699000761 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 633699000762 alanine racemase; Reviewed; Region: alr; PRK00053 633699000763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 633699000764 active site 633699000765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633699000766 dimer interface [polypeptide binding]; other site 633699000767 substrate binding site [chemical binding]; other site 633699000768 catalytic residues [active] 633699000769 FOG: CBS domain [General function prediction only]; Region: COG0517 633699000770 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 633699000771 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 633699000772 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699000773 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699000774 NAD binding site [chemical binding]; other site 633699000775 dimer interface [polypeptide binding]; other site 633699000776 substrate binding site [chemical binding]; other site 633699000777 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 633699000778 putative active site [active] 633699000779 catalytic residue [active] 633699000780 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 633699000781 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 633699000782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699000783 ATP binding site [chemical binding]; other site 633699000784 putative Mg++ binding site [ion binding]; other site 633699000785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699000786 nucleotide binding region [chemical binding]; other site 633699000787 ATP-binding site [chemical binding]; other site 633699000788 TRCF domain; Region: TRCF; cl04088 633699000789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699000790 RNA binding surface [nucleotide binding]; other site 633699000791 Septum formation initiator; Region: DivIC; cl11433 633699000792 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 633699000793 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699000794 RNA binding site [nucleotide binding]; other site 633699000795 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 633699000796 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 633699000797 Ligand Binding Site [chemical binding]; other site 633699000798 FtsH Extracellular; Region: FtsH_ext; pfam06480 633699000799 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 633699000800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000801 Walker A motif; other site 633699000802 ATP binding site [chemical binding]; other site 633699000803 Walker B motif; other site 633699000804 arginine finger; other site 633699000805 Peptidase family M41; Region: Peptidase_M41; pfam01434 633699000806 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 633699000807 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 633699000808 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 633699000809 dimerization interface [polypeptide binding]; other site 633699000810 domain crossover interface; other site 633699000811 redox-dependent activation switch; other site 633699000812 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 633699000813 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 633699000814 FMN binding site [chemical binding]; other site 633699000815 active site 633699000816 catalytic residues [active] 633699000817 substrate binding site [chemical binding]; other site 633699000818 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 633699000819 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 633699000820 dimer interface [polypeptide binding]; other site 633699000821 putative anticodon binding site; other site 633699000822 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 633699000823 motif 1; other site 633699000824 active site 633699000825 motif 2; other site 633699000826 motif 3; other site 633699000827 Clp protease ATP binding subunit; Region: clpC; CHL00095 633699000828 Clp amino terminal domain; Region: Clp_N; pfam02861 633699000829 Clp amino terminal domain; Region: Clp_N; pfam02861 633699000830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000831 Walker A motif; other site 633699000832 ATP binding site [chemical binding]; other site 633699000833 Walker B motif; other site 633699000834 arginine finger; other site 633699000835 UvrB/uvrC motif; Region: UVR; pfam02151 633699000836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699000837 Walker A motif; other site 633699000838 ATP binding site [chemical binding]; other site 633699000839 Walker B motif; other site 633699000840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 633699000841 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 633699000842 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 633699000843 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 633699000844 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 633699000845 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 633699000846 RPB1 interaction site [polypeptide binding]; other site 633699000847 RPB10 interaction site [polypeptide binding]; other site 633699000848 RPB11 interaction site [polypeptide binding]; other site 633699000849 RPB3 interaction site [polypeptide binding]; other site 633699000850 RPB12 interaction site [polypeptide binding]; other site 633699000851 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 633699000852 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 633699000853 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 633699000854 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 633699000855 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 633699000856 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 633699000857 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 633699000858 DNA binding site [nucleotide binding] 633699000859 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 633699000860 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 633699000861 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 633699000862 S17 interaction site [polypeptide binding]; other site 633699000863 S8 interaction site; other site 633699000864 16S rRNA interaction site [nucleotide binding]; other site 633699000865 streptomycin interaction site [chemical binding]; other site 633699000866 23S rRNA interaction site [nucleotide binding]; other site 633699000867 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 633699000868 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 633699000869 elongation factor G; Reviewed; Region: PRK12739 633699000870 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 633699000871 G1 box; other site 633699000872 putative GEF interaction site [polypeptide binding]; other site 633699000873 GTP/Mg2+ binding site [chemical binding]; other site 633699000874 Switch I region; other site 633699000875 G2 box; other site 633699000876 G3 box; other site 633699000877 Switch II region; other site 633699000878 G4 box; other site 633699000879 G5 box; other site 633699000880 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633699000881 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633699000882 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633699000883 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 633699000884 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 633699000885 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 633699000886 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 633699000887 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 633699000888 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 633699000889 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 633699000890 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 633699000891 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 633699000892 putative translocon binding site; other site 633699000893 protein-rRNA interface [nucleotide binding]; other site 633699000894 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 633699000895 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 633699000896 G-X-X-G motif; other site 633699000897 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 633699000898 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 633699000899 23S rRNA interface [nucleotide binding]; other site 633699000900 5S rRNA interface [nucleotide binding]; other site 633699000901 putative antibiotic binding site [chemical binding]; other site 633699000902 L25 interface [polypeptide binding]; other site 633699000903 L27 interface [polypeptide binding]; other site 633699000904 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 633699000905 23S rRNA interface [nucleotide binding]; other site 633699000906 putative translocon interaction site; other site 633699000907 signal recognition particle (SRP54) interaction site; other site 633699000908 L23 interface [polypeptide binding]; other site 633699000909 trigger factor interaction site; other site 633699000910 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 633699000911 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 633699000912 KOW motif; Region: KOW; cl00354 633699000913 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 633699000914 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 633699000915 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 633699000916 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 633699000917 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 633699000918 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 633699000919 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633699000920 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633699000921 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 633699000922 23S rRNA interface [nucleotide binding]; other site 633699000923 L21e interface [polypeptide binding]; other site 633699000924 5S rRNA interface [nucleotide binding]; other site 633699000925 L27 interface [polypeptide binding]; other site 633699000926 L5 interface [polypeptide binding]; other site 633699000927 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 633699000928 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 633699000929 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 633699000930 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 633699000931 23S rRNA binding site [nucleotide binding]; other site 633699000932 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 633699000933 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 633699000934 SecY translocase; Region: SecY; pfam00344 633699000935 adenylate kinase; Reviewed; Region: adk; PRK00279 633699000936 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 633699000937 AMP-binding site [chemical binding]; other site 633699000938 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 633699000939 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 633699000940 rRNA binding site [nucleotide binding]; other site 633699000941 predicted 30S ribosome binding site; other site 633699000942 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 633699000943 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 633699000944 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 633699000945 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 633699000946 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 633699000947 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 633699000948 alphaNTD homodimer interface [polypeptide binding]; other site 633699000949 alphaNTD - beta interaction site [polypeptide binding]; other site 633699000950 alphaNTD - beta' interaction site [polypeptide binding]; other site 633699000951 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 633699000952 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 633699000953 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 633699000954 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000955 Walker A/P-loop; other site 633699000956 ATP binding site [chemical binding]; other site 633699000957 Q-loop/lid; other site 633699000958 ABC transporter signature motif; other site 633699000959 Walker B; other site 633699000960 D-loop; other site 633699000961 H-loop/switch region; other site 633699000962 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 633699000963 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699000964 Walker A/P-loop; other site 633699000965 ATP binding site [chemical binding]; other site 633699000966 Q-loop/lid; other site 633699000967 ABC transporter signature motif; other site 633699000968 Walker B; other site 633699000969 D-loop; other site 633699000970 H-loop/switch region; other site 633699000971 Cobalt transport protein; Region: CbiQ; cl00463 633699000972 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 633699000973 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 633699000974 dimerization interface 3.5A [polypeptide binding]; other site 633699000975 active site 633699000976 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 633699000977 23S rRNA interface [nucleotide binding]; other site 633699000978 L3 interface [polypeptide binding]; other site 633699000979 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 633699000980 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 633699000981 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699000982 active site 633699000983 DNA binding site [nucleotide binding] 633699000984 Int/Topo IB signature motif; other site 633699000985 Plasmid replication protein; Region: Rep_2; pfam01719 633699000986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699000987 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 633699000988 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 633699000989 Divergent AAA domain; Region: AAA_4; pfam04326 633699000990 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 633699000991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699000992 NAD(P) binding site [chemical binding]; other site 633699000993 active site 633699000994 DJ-1 family protein; Region: not_thiJ; TIGR01383 633699000995 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 633699000996 conserved cys residue [active] 633699000997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699000998 catalytic core [active] 633699000999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633699001000 dimerization interface [polypeptide binding]; other site 633699001001 putative DNA binding site [nucleotide binding]; other site 633699001002 putative Zn2+ binding site [ion binding]; other site 633699001003 Cation efflux family; Region: Cation_efflux; cl00316 633699001004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699001005 catalytic core [active] 633699001006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699001007 AAA domain; Region: AAA_33; pfam13671 633699001008 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699001009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699001010 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699001011 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699001012 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699001013 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001014 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699001015 trimer interface [polypeptide binding]; other site 633699001016 active site 633699001017 G bulge; other site 633699001018 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699001019 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699001020 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 633699001021 trimer interface [polypeptide binding]; other site 633699001022 active site 633699001023 DNA repair protein RadA; Provisional; Region: PRK11823 633699001024 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 633699001025 Walker A motif/ATP binding site; other site 633699001026 ATP binding site [chemical binding]; other site 633699001027 Walker B motif; other site 633699001028 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 633699001029 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 633699001030 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633699001031 active site 633699001032 HIGH motif; other site 633699001033 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633699001034 active site 633699001035 KMSKS motif; other site 633699001036 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 633699001037 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633699001038 active site 633699001039 HIGH motif; other site 633699001040 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633699001041 KMSKS motif; other site 633699001042 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 633699001043 tRNA binding surface [nucleotide binding]; other site 633699001044 anticodon binding site; other site 633699001045 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 633699001046 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 633699001047 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 633699001048 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 633699001049 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 633699001050 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 633699001051 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 633699001052 N- and C-terminal domain interface [polypeptide binding]; other site 633699001053 putative active site [active] 633699001054 catalytic site [active] 633699001055 metal binding site [ion binding]; metal-binding site 633699001056 carbohydrate binding site [chemical binding]; other site 633699001057 ATP binding site [chemical binding]; other site 633699001058 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 633699001059 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 633699001060 TPP-binding site; other site 633699001061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633699001062 PYR/PP interface [polypeptide binding]; other site 633699001063 dimer interface [polypeptide binding]; other site 633699001064 TPP binding site [chemical binding]; other site 633699001065 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633699001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001068 putative substrate translocation pore; other site 633699001069 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 633699001070 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633699001071 substrate binding pocket [chemical binding]; other site 633699001072 chain length determination region; other site 633699001073 substrate-Mg2+ binding site; other site 633699001074 catalytic residues [active] 633699001075 aspartate-rich region 1; other site 633699001076 active site lid residues [active] 633699001077 aspartate-rich region 2; other site 633699001078 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 633699001079 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 633699001080 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 633699001081 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 633699001082 putative homodimer interface [polypeptide binding]; other site 633699001083 KOW motif; Region: KOW; cl00354 633699001084 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 633699001085 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 633699001086 23S rRNA interface [nucleotide binding]; other site 633699001087 L7/L12 interface [polypeptide binding]; other site 633699001088 putative thiostrepton binding site; other site 633699001089 L25 interface [polypeptide binding]; other site 633699001090 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 633699001091 mRNA/rRNA interface [nucleotide binding]; other site 633699001092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 633699001093 Probable transposase; Region: OrfB_IS605; pfam01385 633699001094 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 633699001095 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001097 dimer interface [polypeptide binding]; other site 633699001098 conserved gate region; other site 633699001099 putative PBP binding loops; other site 633699001100 ABC-ATPase subunit interface; other site 633699001101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699001102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001103 Walker A/P-loop; other site 633699001104 ATP binding site [chemical binding]; other site 633699001105 Q-loop/lid; other site 633699001106 ABC transporter signature motif; other site 633699001107 Walker B; other site 633699001108 D-loop; other site 633699001109 H-loop/switch region; other site 633699001110 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001112 substrate binding pocket [chemical binding]; other site 633699001113 membrane-bound complex binding site; other site 633699001114 hinge residues; other site 633699001115 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 633699001116 23S rRNA interface [nucleotide binding]; other site 633699001117 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 633699001118 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 633699001119 core dimer interface [polypeptide binding]; other site 633699001120 peripheral dimer interface [polypeptide binding]; other site 633699001121 L10 interface [polypeptide binding]; other site 633699001122 L11 interface [polypeptide binding]; other site 633699001123 putative EF-Tu interaction site [polypeptide binding]; other site 633699001124 putative EF-G interaction site [polypeptide binding]; other site 633699001125 Ion transport protein; Region: Ion_trans; pfam00520 633699001126 Ion channel; Region: Ion_trans_2; cl11596 633699001127 Methyltransferase domain; Region: Methyltransf_31; pfam13847 633699001128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699001129 S-adenosylmethionine binding site [chemical binding]; other site 633699001130 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 633699001131 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 633699001132 nucleoside/Zn binding site; other site 633699001133 dimer interface [polypeptide binding]; other site 633699001134 catalytic motif [active] 633699001135 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 633699001136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001137 Walker A motif; other site 633699001138 ATP binding site [chemical binding]; other site 633699001139 Walker B motif; other site 633699001140 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 633699001141 recombination protein RecR; Reviewed; Region: recR; PRK00076 633699001142 RecR protein; Region: RecR; pfam02132 633699001143 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 633699001144 putative active site [active] 633699001145 putative metal-binding site [ion binding]; other site 633699001146 tetramer interface [polypeptide binding]; other site 633699001147 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 633699001148 thymidylate kinase; Validated; Region: tmk; PRK00698 633699001149 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 633699001150 TMP-binding site; other site 633699001151 ATP-binding site [chemical binding]; other site 633699001152 Nitrogen regulatory protein P-II; Region: P-II; cl00412 633699001153 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 633699001154 TSC-22/dip/bun family; Region: TSC22; cl01853 633699001155 Predicted methyltransferases [General function prediction only]; Region: COG0313 633699001156 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 633699001157 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 633699001158 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 633699001159 active site 633699001160 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 633699001161 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 633699001162 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 633699001163 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633699001164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699001165 Coenzyme A binding pocket [chemical binding]; other site 633699001166 UGMP family protein; Validated; Region: PRK09604 633699001167 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 633699001168 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 633699001169 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 633699001170 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 633699001171 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 633699001172 active site 633699001173 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 633699001174 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 633699001175 GDP-binding site [chemical binding]; other site 633699001176 ACT binding site; other site 633699001177 IMP binding site; other site 633699001178 adenylosuccinate lyase; Provisional; Region: PRK07492 633699001179 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 633699001180 tetramer interface [polypeptide binding]; other site 633699001181 active site 633699001182 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 633699001183 active site 633699001184 Ap4A binding cleft/pocket [chemical binding]; other site 633699001185 P4 phosphate binding site; other site 633699001186 nudix motif; other site 633699001187 putative P2/P3 phosphate binding site [ion binding]; other site 633699001188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 633699001189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699001190 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699001191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001192 Walker A/P-loop; other site 633699001193 ATP binding site [chemical binding]; other site 633699001194 Q-loop/lid; other site 633699001195 ABC transporter signature motif; other site 633699001196 Walker B; other site 633699001197 D-loop; other site 633699001198 H-loop/switch region; other site 633699001199 ABC transporter; Region: ABC_tran_2; pfam12848 633699001200 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699001201 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 633699001202 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 633699001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699001204 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 633699001205 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633699001206 LytTr DNA-binding domain; Region: LytTR; cl04498 633699001207 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 633699001208 oligomerisation interface [polypeptide binding]; other site 633699001209 mobile loop; other site 633699001210 roof hairpin; other site 633699001211 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 633699001212 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 633699001213 ring oligomerisation interface [polypeptide binding]; other site 633699001214 ATP/Mg binding site [chemical binding]; other site 633699001215 stacking interactions; other site 633699001216 hinge regions; other site 633699001217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699001218 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 633699001219 Walker A/P-loop; other site 633699001220 ATP binding site [chemical binding]; other site 633699001221 Q-loop/lid; other site 633699001222 ABC transporter signature motif; other site 633699001223 Walker B; other site 633699001224 D-loop; other site 633699001225 H-loop/switch region; other site 633699001226 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 633699001227 MutS domain I; Region: MutS_I; pfam01624 633699001228 MutS domain II; Region: MutS_II; pfam05188 633699001229 MutS family domain IV; Region: MutS_IV; pfam05190 633699001230 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 633699001231 Walker A/P-loop; other site 633699001232 ATP binding site [chemical binding]; other site 633699001233 Q-loop/lid; other site 633699001234 ABC transporter signature motif; other site 633699001235 Walker B; other site 633699001236 D-loop; other site 633699001237 H-loop/switch region; other site 633699001238 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 633699001239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699001240 ATP binding site [chemical binding]; other site 633699001241 Mg2+ binding site [ion binding]; other site 633699001242 G-X-G motif; other site 633699001243 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 633699001244 ATP binding site [chemical binding]; other site 633699001245 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 633699001246 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 633699001247 RuvA N terminal domain; Region: RuvA_N; pfam01330 633699001248 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 633699001249 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 633699001250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001251 Walker A motif; other site 633699001252 ATP binding site [chemical binding]; other site 633699001253 Walker B motif; other site 633699001254 arginine finger; other site 633699001255 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 633699001256 Preprotein translocase subunit; Region: YajC; cl00806 633699001257 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 633699001258 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 633699001259 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 633699001260 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 633699001261 active site 633699001262 DNA polymerase IV; Validated; Region: PRK02406 633699001263 DNA binding site [nucleotide binding] 633699001264 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 633699001265 DHH family; Region: DHH; pfam01368 633699001266 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 633699001267 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699001268 ATP binding site [chemical binding]; other site 633699001269 Mg++ binding site [ion binding]; other site 633699001270 motif III; other site 633699001271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001272 nucleotide binding region [chemical binding]; other site 633699001273 ATP-binding site [chemical binding]; other site 633699001274 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 633699001275 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 633699001276 motif 1; other site 633699001277 active site 633699001278 motif 2; other site 633699001279 motif 3; other site 633699001280 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 633699001281 DHHA1 domain; Region: DHHA1; pfam02272 633699001282 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 633699001283 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 633699001284 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 633699001285 Colicin V production protein; Region: Colicin_V; cl00567 633699001286 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 633699001287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001288 Walker A/P-loop; other site 633699001289 ATP binding site [chemical binding]; other site 633699001290 Q-loop/lid; other site 633699001291 ABC transporter signature motif; other site 633699001292 Walker B; other site 633699001293 D-loop; other site 633699001294 H-loop/switch region; other site 633699001295 Smr domain; Region: Smr; cl02619 633699001296 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633699001297 catalytic residues [active] 633699001298 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 633699001299 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 633699001300 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 633699001301 active site 633699001302 dimerization interface [polypeptide binding]; other site 633699001303 Integrase core domain; Region: rve; cl01316 633699001304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699001305 Helix-turn-helix domains; Region: HTH; cl00088 633699001306 Helix-turn-helix domains; Region: HTH; cl00088 633699001307 Acetokinase family; Region: Acetate_kinase; cl01029 633699001308 propionate/acetate kinase; Provisional; Region: PRK12379 633699001309 Mechanosensitive ion channel; Region: MS_channel; pfam00924 633699001310 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 633699001311 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633699001312 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633699001313 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633699001314 active site 633699001315 catabolite control protein A; Region: ccpA; TIGR01481 633699001316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699001317 DNA binding site [nucleotide binding] 633699001318 domain linker motif; other site 633699001319 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 633699001320 dimerization interface [polypeptide binding]; other site 633699001321 effector binding site; other site 633699001322 Transglycosylase; Region: Transgly; cl07896 633699001323 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699001324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699001325 dipeptidase PepV; Reviewed; Region: PRK07318 633699001326 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 633699001327 active site 633699001328 metal binding site [ion binding]; metal-binding site 633699001329 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699001330 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 633699001331 active site 633699001332 catalytic site [active] 633699001333 metal binding site [ion binding]; metal-binding site 633699001334 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 633699001335 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 633699001336 active site 633699001337 metal binding site [ion binding]; metal-binding site 633699001338 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 633699001339 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 633699001340 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 633699001341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001342 active site 633699001343 motif I; other site 633699001344 motif II; other site 633699001345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001346 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 633699001347 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633699001348 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 633699001349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699001350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699001351 general stress protein 13; Validated; Region: PRK08059 633699001352 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699001353 RNA binding site [nucleotide binding]; other site 633699001354 S-adenosylmethionine synthetase; Validated; Region: PRK05250 633699001355 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 633699001356 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 633699001357 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 633699001358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001360 putative substrate translocation pore; other site 633699001361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001362 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633699001363 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699001364 active site 633699001365 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 633699001366 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633699001367 HIGH motif; other site 633699001368 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633699001369 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633699001370 active site 633699001371 KMSKS motif; other site 633699001372 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 633699001373 tRNA binding surface [nucleotide binding]; other site 633699001374 MatE; Region: MatE; cl10513 633699001375 stage V sporulation protein B; Region: spore_V_B; TIGR02900 633699001376 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 633699001377 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 633699001378 putative substrate binding site [chemical binding]; other site 633699001379 putative ATP binding site [chemical binding]; other site 633699001380 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 633699001381 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699001382 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 633699001383 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 633699001384 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 633699001385 active site 633699001386 HIGH motif; other site 633699001387 KMSK motif region; other site 633699001388 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 633699001389 tRNA binding surface [nucleotide binding]; other site 633699001390 anticodon binding site; other site 633699001391 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633699001392 hypothetical protein; Provisional; Region: PRK08185 633699001393 intersubunit interface [polypeptide binding]; other site 633699001394 active site 633699001395 zinc binding site [ion binding]; other site 633699001396 Na+ binding site [ion binding]; other site 633699001397 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 633699001398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699001399 Walker A motif; other site 633699001400 ATP binding site [chemical binding]; other site 633699001401 Walker B motif; other site 633699001402 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 633699001403 Transcriptional antiterminator [Transcription]; Region: COG3933 633699001404 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633699001405 active site 633699001406 active pocket/dimerization site; other site 633699001407 phosphorylation site [posttranslational modification] 633699001408 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 633699001409 MgtC family; Region: MgtC; pfam02308 633699001410 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 633699001411 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 633699001412 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 633699001413 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 633699001414 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 633699001415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699001416 active site 633699001417 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 633699001418 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 633699001419 catalytic triad [active] 633699001420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699001421 NAD(P) binding site [chemical binding]; other site 633699001422 active site 633699001423 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 633699001424 Probable transposase; Region: OrfB_IS605; pfam01385 633699001425 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 633699001426 Transposase IS200 like; Region: Y1_Tnp; cl00848 633699001427 GAF domain; Region: GAF; cl15785 633699001428 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 633699001429 Cl- selectivity filter; other site 633699001430 Cl- binding residues [ion binding]; other site 633699001431 pore gating glutamate residue; other site 633699001432 dimer interface [polypeptide binding]; other site 633699001433 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 633699001434 Membrane transport protein; Region: Mem_trans; cl09117 633699001435 Membrane transport protein; Region: Mem_trans; cl09117 633699001436 CAAX protease self-immunity; Region: Abi; cl00558 633699001437 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 633699001438 amphipathic channel; other site 633699001439 Asn-Pro-Ala signature motifs; other site 633699001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001442 putative substrate translocation pore; other site 633699001443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 633699001445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001446 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699001447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001448 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001449 active site 633699001450 motif I; other site 633699001451 motif II; other site 633699001452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001453 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699001454 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 633699001455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001456 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001457 active site 633699001458 motif I; other site 633699001459 motif II; other site 633699001460 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699001461 Cupin domain; Region: Cupin_2; cl09118 633699001462 Helix-turn-helix domain; Region: HTH_18; pfam12833 633699001463 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 633699001464 uracil transporter; Provisional; Region: PRK10720 633699001465 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633699001466 Helix-turn-helix domains; Region: HTH; cl00088 633699001467 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 633699001468 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 633699001469 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 633699001470 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699001471 active site 633699001472 phosphorylation site [posttranslational modification] 633699001473 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633699001474 active site 633699001475 P-loop; other site 633699001476 phosphorylation site [posttranslational modification] 633699001477 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633699001478 transcriptional antiterminator BglG; Provisional; Region: PRK09772 633699001479 CAT RNA binding domain; Region: CAT_RBD; cl03904 633699001480 PRD domain; Region: PRD; cl15445 633699001481 PRD domain; Region: PRD; cl15445 633699001482 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 633699001483 methionine cluster; other site 633699001484 active site 633699001485 phosphorylation site [posttranslational modification] 633699001486 metal binding site [ion binding]; metal-binding site 633699001487 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699001488 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 633699001489 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633699001490 active site 633699001491 P-loop; other site 633699001492 phosphorylation site [posttranslational modification] 633699001493 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699001494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699001495 Helix-turn-helix domains; Region: HTH; cl00088 633699001496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699001497 dimerization interface [polypeptide binding]; other site 633699001498 hypothetical protein; Validated; Region: PRK07121 633699001499 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 633699001500 FMN-binding domain; Region: FMN_bind; cl01081 633699001501 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 633699001502 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 633699001503 transmembrane helices; other site 633699001504 Glutaminase; Region: Glutaminase; cl00907 633699001505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699001506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699001507 DNA binding site [nucleotide binding] 633699001508 domain linker motif; other site 633699001509 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 633699001510 dimerization interface [polypeptide binding]; other site 633699001511 ligand binding site [chemical binding]; other site 633699001512 sodium binding site [ion binding]; other site 633699001513 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 633699001514 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699001515 active site turn [active] 633699001516 phosphorylation site [posttranslational modification] 633699001517 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699001518 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 633699001519 HPr interaction site; other site 633699001520 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699001521 active site 633699001522 phosphorylation site [posttranslational modification] 633699001523 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 633699001524 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 633699001525 Ca binding site [ion binding]; other site 633699001526 active site 633699001527 catalytic site [active] 633699001528 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 633699001529 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 633699001530 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633699001531 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699001532 active site 633699001533 Phospholipase B; Region: Phospholip_B; pfam04916 633699001534 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001535 active site 633699001536 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001537 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001538 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 633699001539 active site 633699001540 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001541 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001542 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001543 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 633699001544 cationic amino acid transport permease; Region: 2A0303; TIGR00906 633699001545 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 633699001546 drug efflux system protein MdtG; Provisional; Region: PRK09874 633699001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001548 putative substrate translocation pore; other site 633699001549 Helix-turn-helix domains; Region: HTH; cl00088 633699001550 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 633699001551 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 633699001552 oligomer interface [polypeptide binding]; other site 633699001553 active site 633699001554 metal binding site [ion binding]; metal-binding site 633699001555 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 633699001556 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699001557 Walker A/P-loop; other site 633699001558 ATP binding site [chemical binding]; other site 633699001559 Q-loop/lid; other site 633699001560 ABC transporter signature motif; other site 633699001561 Walker B; other site 633699001562 D-loop; other site 633699001563 H-loop/switch region; other site 633699001564 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 633699001565 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 633699001566 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 633699001567 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 633699001568 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 633699001569 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 633699001570 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 633699001571 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 633699001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 633699001573 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699001574 benzoate transport; Region: 2A0115; TIGR00895 633699001575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001576 putative substrate translocation pore; other site 633699001577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699001578 Helix-turn-helix domains; Region: HTH; cl00088 633699001579 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699001580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001581 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699001582 Walker A/P-loop; other site 633699001583 ATP binding site [chemical binding]; other site 633699001584 Q-loop/lid; other site 633699001585 ABC transporter signature motif; other site 633699001586 Walker B; other site 633699001587 D-loop; other site 633699001588 H-loop/switch region; other site 633699001589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699001590 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699001591 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 633699001592 Walker A/P-loop; other site 633699001593 ATP binding site [chemical binding]; other site 633699001594 Q-loop/lid; other site 633699001595 ABC transporter signature motif; other site 633699001596 Walker B; other site 633699001597 D-loop; other site 633699001598 H-loop/switch region; other site 633699001599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001600 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001601 substrate binding pocket [chemical binding]; other site 633699001602 membrane-bound complex binding site; other site 633699001603 hinge residues; other site 633699001604 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001605 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 633699001606 Walker A/P-loop; other site 633699001607 ATP binding site [chemical binding]; other site 633699001608 Q-loop/lid; other site 633699001609 ABC transporter signature motif; other site 633699001610 Walker B; other site 633699001611 D-loop; other site 633699001612 H-loop/switch region; other site 633699001613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001615 substrate binding pocket [chemical binding]; other site 633699001616 membrane-bound complex binding site; other site 633699001617 hinge residues; other site 633699001618 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699001619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001620 dimer interface [polypeptide binding]; other site 633699001621 conserved gate region; other site 633699001622 putative PBP binding loops; other site 633699001623 ABC-ATPase subunit interface; other site 633699001624 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633699001625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001626 dimer interface [polypeptide binding]; other site 633699001627 conserved gate region; other site 633699001628 putative PBP binding loops; other site 633699001629 ABC-ATPase subunit interface; other site 633699001630 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699001631 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699001632 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699001633 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 633699001634 Sugar specificity; other site 633699001635 Pyrimidine base specificity; other site 633699001636 ATP-binding site [chemical binding]; other site 633699001637 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699001638 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699001639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699001640 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699001641 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699001642 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699001643 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 633699001644 active site 633699001645 nucleophile elbow; other site 633699001646 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 633699001647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633699001648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699001649 substrate binding pocket [chemical binding]; other site 633699001650 membrane-bound complex binding site; other site 633699001651 hinge residues; other site 633699001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001653 dimer interface [polypeptide binding]; other site 633699001654 conserved gate region; other site 633699001655 putative PBP binding loops; other site 633699001656 ABC-ATPase subunit interface; other site 633699001657 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001658 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 633699001659 Walker A/P-loop; other site 633699001660 ATP binding site [chemical binding]; other site 633699001661 Q-loop/lid; other site 633699001662 ABC transporter signature motif; other site 633699001663 Walker B; other site 633699001664 D-loop; other site 633699001665 H-loop/switch region; other site 633699001666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633699001667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699001668 Coenzyme A binding pocket [chemical binding]; other site 633699001669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699001670 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 633699001671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001672 dimer interface [polypeptide binding]; other site 633699001673 conserved gate region; other site 633699001674 putative PBP binding loops; other site 633699001675 ABC-ATPase subunit interface; other site 633699001676 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 633699001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001678 dimer interface [polypeptide binding]; other site 633699001679 conserved gate region; other site 633699001680 putative PBP binding loops; other site 633699001681 ABC-ATPase subunit interface; other site 633699001682 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 633699001683 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 633699001684 Walker A/P-loop; other site 633699001685 ATP binding site [chemical binding]; other site 633699001686 Q-loop/lid; other site 633699001687 ABC transporter signature motif; other site 633699001688 Walker B; other site 633699001689 D-loop; other site 633699001690 H-loop/switch region; other site 633699001691 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 633699001692 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 633699001693 Walker A/P-loop; other site 633699001694 ATP binding site [chemical binding]; other site 633699001695 Q-loop/lid; other site 633699001696 ABC transporter signature motif; other site 633699001697 Walker B; other site 633699001698 D-loop; other site 633699001699 H-loop/switch region; other site 633699001700 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 633699001701 PhoU domain; Region: PhoU; pfam01895 633699001702 PhoU domain; Region: PhoU; pfam01895 633699001703 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699001704 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 633699001705 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 633699001706 dimerization interface [polypeptide binding]; other site 633699001707 DPS ferroxidase diiron center [ion binding]; other site 633699001708 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633699001709 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 633699001710 substrate binding site [chemical binding]; other site 633699001711 dimer interface [polypeptide binding]; other site 633699001712 ATP binding site [chemical binding]; other site 633699001713 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 633699001714 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699001715 active site 633699001716 dimer interface [polypeptide binding]; other site 633699001717 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 633699001718 active site 633699001719 tetramer interface [polypeptide binding]; other site 633699001720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699001721 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699001722 DNA-binding site [nucleotide binding]; DNA binding site 633699001723 UTRA domain; Region: UTRA; cl01230 633699001724 Helix-turn-helix domains; Region: HTH; cl00088 633699001725 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 633699001726 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 633699001727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001728 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001729 putative phosphoketolase; Provisional; Region: PRK05261 633699001730 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 633699001731 TPP-binding site; other site 633699001732 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 633699001733 XFP C-terminal domain; Region: XFP_C; pfam09363 633699001734 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 633699001735 putative FMN binding site [chemical binding]; other site 633699001736 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 633699001737 Domain of unknown function DUF21; Region: DUF21; pfam01595 633699001738 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633699001739 Transporter associated domain; Region: CorC_HlyC; cl08393 633699001740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699001741 active site 633699001742 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 633699001743 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 633699001744 active site 633699001745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001746 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699001747 ATP binding site [chemical binding]; other site 633699001748 putative Mg++ binding site [ion binding]; other site 633699001749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001750 nucleotide binding region [chemical binding]; other site 633699001751 ATP-binding site [chemical binding]; other site 633699001752 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699001753 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699001754 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 633699001755 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 633699001756 active site 633699001757 homodimer interface [polypeptide binding]; other site 633699001758 GtrA-like protein; Region: GtrA; cl00971 633699001759 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 633699001760 methionine aminopeptidase; Provisional; Region: PRK08671 633699001761 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 633699001762 active site 633699001763 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 633699001764 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 633699001765 active site 633699001766 tetramer interface; other site 633699001767 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699001768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699001769 Walker A/P-loop; other site 633699001770 ATP binding site [chemical binding]; other site 633699001771 Q-loop/lid; other site 633699001772 ABC transporter signature motif; other site 633699001773 Walker B; other site 633699001774 D-loop; other site 633699001775 H-loop/switch region; other site 633699001776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699001777 dimer interface [polypeptide binding]; other site 633699001778 conserved gate region; other site 633699001779 ABC-ATPase subunit interface; other site 633699001780 NMT1-like family; Region: NMT1_2; cl15260 633699001781 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 633699001782 OsmC-like protein; Region: OsmC; cl00767 633699001783 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001784 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699001785 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699001786 synthetase active site [active] 633699001787 NTP binding site [chemical binding]; other site 633699001788 metal binding site [ion binding]; metal-binding site 633699001789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699001790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699001791 active site 633699001792 phosphorylation site [posttranslational modification] 633699001793 intermolecular recognition site; other site 633699001794 dimerization interface [polypeptide binding]; other site 633699001795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699001796 DNA binding site [nucleotide binding] 633699001797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699001798 dimer interface [polypeptide binding]; other site 633699001799 phosphorylation site [posttranslational modification] 633699001800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699001801 ATP binding site [chemical binding]; other site 633699001802 Mg2+ binding site [ion binding]; other site 633699001803 G-X-G motif; other site 633699001804 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 633699001805 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 633699001806 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 633699001807 Peptidase family M1; Region: Peptidase_M1; pfam01433 633699001808 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 633699001809 Zn binding site [ion binding]; other site 633699001810 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 633699001811 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699001812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001813 active site 633699001814 motif I; other site 633699001815 motif II; other site 633699001816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699001817 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 633699001818 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 633699001819 glutaminase active site [active] 633699001820 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633699001821 dimer interface [polypeptide binding]; other site 633699001822 active site 633699001823 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 633699001824 dimer interface [polypeptide binding]; other site 633699001825 active site 633699001826 Fic/DOC family; Region: Fic; cl00960 633699001827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 633699001828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699001829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699001830 putative substrate translocation pore; other site 633699001831 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 633699001832 DNA binding residues [nucleotide binding] 633699001833 putative dimer interface [polypeptide binding]; other site 633699001834 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 633699001835 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 633699001836 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 633699001837 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633699001838 trimer interface [polypeptide binding]; other site 633699001839 active site 633699001840 G bulge; other site 633699001841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 633699001842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699001843 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 633699001844 substrate binding pocket [chemical binding]; other site 633699001845 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 633699001846 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 633699001847 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 633699001848 dimer interface [polypeptide binding]; other site 633699001849 pyridoxal binding site [chemical binding]; other site 633699001850 ATP binding site [chemical binding]; other site 633699001851 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 633699001852 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 633699001853 active site 1 [active] 633699001854 dimer interface [polypeptide binding]; other site 633699001855 hexamer interface [polypeptide binding]; other site 633699001856 active site 2 [active] 633699001857 Phycobilisome protein; Region: Phycobilisome; cl08227 633699001858 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 633699001859 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633699001860 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699001861 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 633699001862 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 633699001863 ArsC family; Region: ArsC; pfam03960 633699001864 putative ArsC-like catalytic residues; other site 633699001865 putative TRX-like catalytic residues [active] 633699001866 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 633699001867 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 633699001868 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633699001869 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633699001870 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633699001871 active site 633699001872 elongation factor P; Validated; Region: PRK00529 633699001873 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633699001874 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633699001875 RNA binding site [nucleotide binding]; other site 633699001876 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 633699001877 RNA binding site [nucleotide binding]; other site 633699001878 Asp23 family; Region: Asp23; cl00574 633699001879 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 633699001880 putative RNA binding site [nucleotide binding]; other site 633699001881 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 633699001882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633699001883 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633699001884 homodimer interface [polypeptide binding]; other site 633699001885 NADP binding site [chemical binding]; other site 633699001886 substrate binding site [chemical binding]; other site 633699001887 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 633699001888 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 633699001889 generic binding surface II; other site 633699001890 generic binding surface I; other site 633699001891 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 633699001892 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633699001893 substrate binding pocket [chemical binding]; other site 633699001894 chain length determination region; other site 633699001895 substrate-Mg2+ binding site; other site 633699001896 catalytic residues [active] 633699001897 aspartate-rich region 1; other site 633699001898 active site lid residues [active] 633699001899 aspartate-rich region 2; other site 633699001900 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 633699001901 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 633699001902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 633699001903 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 633699001904 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 633699001905 Walker A/P-loop; other site 633699001906 ATP binding site [chemical binding]; other site 633699001907 Q-loop/lid; other site 633699001908 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 633699001909 ABC transporter signature motif; other site 633699001910 Walker B; other site 633699001911 D-loop; other site 633699001912 H-loop/switch region; other site 633699001913 HTH-like domain; Region: HTH_21; pfam13276 633699001914 Integrase core domain; Region: rve; cl01316 633699001915 Integrase core domain; Region: rve_3; cl15866 633699001916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699001917 Helix-turn-helix domains; Region: HTH; cl00088 633699001918 Helix-turn-helix domains; Region: HTH; cl00088 633699001919 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633699001920 catalytic site [active] 633699001921 G-X2-G-X-G-K; other site 633699001922 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 633699001923 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 633699001924 primosome assembly protein PriA; Validated; Region: PRK05580 633699001925 primosome assembly protein PriA; Validated; Region: PRK05580 633699001926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699001927 ATP binding site [chemical binding]; other site 633699001928 putative Mg++ binding site [ion binding]; other site 633699001929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001930 nucleotide binding region [chemical binding]; other site 633699001931 ATP-binding site [chemical binding]; other site 633699001932 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 633699001933 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 633699001934 putative active site [active] 633699001935 substrate binding site [chemical binding]; other site 633699001936 putative cosubstrate binding site; other site 633699001937 catalytic site [active] 633699001938 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 633699001939 substrate binding site [chemical binding]; other site 633699001940 16S rRNA methyltransferase B; Provisional; Region: PRK14902 633699001941 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 633699001942 putative RNA binding site [nucleotide binding]; other site 633699001943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 633699001944 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 633699001945 active site 633699001946 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 633699001947 Catalytic domain of Protein Kinases; Region: PKc; cd00180 633699001948 active site 633699001949 ATP binding site [chemical binding]; other site 633699001950 substrate binding site [chemical binding]; other site 633699001951 activation loop (A-loop); other site 633699001952 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699001953 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699001954 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633699001955 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 633699001956 GTPase RsgA; Reviewed; Region: PRK00098 633699001957 RNA binding site [nucleotide binding]; other site 633699001958 homodimer interface [polypeptide binding]; other site 633699001959 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 633699001960 GTPase/Zn-binding domain interface [polypeptide binding]; other site 633699001961 GTP/Mg2+ binding site [chemical binding]; other site 633699001962 G4 box; other site 633699001963 G5 box; other site 633699001964 G1 box; other site 633699001965 Switch I region; other site 633699001966 G2 box; other site 633699001967 G3 box; other site 633699001968 Switch II region; other site 633699001969 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 633699001970 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 633699001971 substrate binding site [chemical binding]; other site 633699001972 hexamer interface [polypeptide binding]; other site 633699001973 metal binding site [ion binding]; metal-binding site 633699001974 Thiamine pyrophosphokinase; Region: TPK; cd07995 633699001975 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 633699001976 active site 633699001977 dimerization interface [polypeptide binding]; other site 633699001978 thiamine binding site [chemical binding]; other site 633699001979 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 633699001980 Asp23 family; Region: Asp23; cl00574 633699001981 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 633699001982 DAK2 domain; Region: Dak2; cl03685 633699001983 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 633699001984 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 633699001985 Y-family of DNA polymerases; Region: PolY; cl12025 633699001986 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 633699001987 ssDNA binding site; other site 633699001988 generic binding surface II; other site 633699001989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699001990 ATP binding site [chemical binding]; other site 633699001991 putative Mg++ binding site [ion binding]; other site 633699001992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699001993 nucleotide binding region [chemical binding]; other site 633699001994 ATP-binding site [chemical binding]; other site 633699001995 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 633699001996 Phosphopantetheine attachment site; Region: PP-binding; cl09936 633699001997 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633699001998 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 633699001999 Walker A/P-loop; other site 633699002000 ATP binding site [chemical binding]; other site 633699002001 Q-loop/lid; other site 633699002002 ABC transporter signature motif; other site 633699002003 Walker B; other site 633699002004 D-loop; other site 633699002005 H-loop/switch region; other site 633699002006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633699002007 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 633699002008 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 633699002009 Walker A/P-loop; other site 633699002010 ATP binding site [chemical binding]; other site 633699002011 Q-loop/lid; other site 633699002012 ABC transporter signature motif; other site 633699002013 Walker B; other site 633699002014 D-loop; other site 633699002015 H-loop/switch region; other site 633699002016 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633699002017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002018 dimer interface [polypeptide binding]; other site 633699002019 conserved gate region; other site 633699002020 putative PBP binding loops; other site 633699002021 ABC-ATPase subunit interface; other site 633699002022 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 633699002023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002024 dimer interface [polypeptide binding]; other site 633699002025 conserved gate region; other site 633699002026 putative PBP binding loops; other site 633699002027 ABC-ATPase subunit interface; other site 633699002028 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699002029 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699002030 peptide binding site [polypeptide binding]; other site 633699002031 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699002032 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699002033 peptide binding site [polypeptide binding]; other site 633699002034 ribonuclease III; Reviewed; Region: rnc; PRK00102 633699002035 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 633699002036 dimerization interface [polypeptide binding]; other site 633699002037 active site 633699002038 metal binding site [ion binding]; metal-binding site 633699002039 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 633699002040 dsRNA binding site [nucleotide binding]; other site 633699002041 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 633699002042 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 633699002043 Walker A/P-loop; other site 633699002044 ATP binding site [chemical binding]; other site 633699002045 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 633699002046 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 633699002047 ABC transporter signature motif; other site 633699002048 Walker B; other site 633699002049 D-loop; other site 633699002050 H-loop/switch region; other site 633699002051 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 633699002052 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 633699002053 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633699002054 P loop; other site 633699002055 GTP binding site [chemical binding]; other site 633699002056 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 633699002057 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699002058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 633699002059 signal recognition particle protein; Provisional; Region: PRK10867 633699002060 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 633699002061 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633699002062 P loop; other site 633699002063 GTP binding site [chemical binding]; other site 633699002064 Signal peptide binding domain; Region: SRP_SPB; pfam02978 633699002065 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 633699002066 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 633699002067 RimM N-terminal domain; Region: RimM; pfam01782 633699002068 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 633699002069 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 633699002070 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 633699002071 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633699002072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002073 Catalytic site [active] 633699002074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002075 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 633699002076 active site 633699002077 Ap4A binding cleft/pocket [chemical binding]; other site 633699002078 P4 phosphate binding site; other site 633699002079 nudix motif; other site 633699002080 putative P2/P3 phosphate binding site [ion binding]; other site 633699002081 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 633699002082 active site 633699002083 Fe-S cluster binding site [ion binding]; other site 633699002084 LexA repressor; Validated; Region: PRK00215 633699002085 Helix-turn-helix domains; Region: HTH; cl00088 633699002086 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 633699002087 Catalytic site [active] 633699002088 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 633699002089 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 633699002090 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002091 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 633699002092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002093 Walker A/P-loop; other site 633699002094 ATP binding site [chemical binding]; other site 633699002095 Q-loop/lid; other site 633699002096 ABC transporter signature motif; other site 633699002097 Walker B; other site 633699002098 D-loop; other site 633699002099 H-loop/switch region; other site 633699002100 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699002101 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002102 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 633699002103 Walker A/P-loop; other site 633699002104 ATP binding site [chemical binding]; other site 633699002105 Q-loop/lid; other site 633699002106 ABC transporter signature motif; other site 633699002107 Walker B; other site 633699002108 D-loop; other site 633699002109 H-loop/switch region; other site 633699002110 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 633699002111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002112 S-adenosylmethionine binding site [chemical binding]; other site 633699002113 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 633699002114 putative acyl-acceptor binding pocket; other site 633699002115 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 633699002116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002117 S-adenosylmethionine binding site [chemical binding]; other site 633699002118 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 633699002119 GIY-YIG motif/motif A; other site 633699002120 putative active site [active] 633699002121 putative metal binding site [ion binding]; other site 633699002122 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 633699002123 rRNA interaction site [nucleotide binding]; other site 633699002124 S8 interaction site; other site 633699002125 putative laminin-1 binding site; other site 633699002126 elongation factor Ts; Provisional; Region: tsf; PRK09377 633699002127 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 633699002128 Elongation factor TS; Region: EF_TS; pfam00889 633699002129 Elongation factor TS; Region: EF_TS; pfam00889 633699002130 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 633699002131 putative nucleotide binding site [chemical binding]; other site 633699002132 uridine monophosphate binding site [chemical binding]; other site 633699002133 homohexameric interface [polypeptide binding]; other site 633699002134 ribosome recycling factor; Reviewed; Region: frr; PRK00083 633699002135 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 633699002136 hinge region; other site 633699002137 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 633699002138 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 633699002139 catalytic residue [active] 633699002140 putative FPP diphosphate binding site; other site 633699002141 putative FPP binding hydrophobic cleft; other site 633699002142 dimer interface [polypeptide binding]; other site 633699002143 putative IPP diphosphate binding site; other site 633699002144 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 633699002145 RIP metalloprotease RseP; Region: TIGR00054 633699002146 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 633699002147 active site 633699002148 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633699002149 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 633699002150 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633699002151 putative substrate binding region [chemical binding]; other site 633699002152 prolyl-tRNA synthetase; Provisional; Region: PRK09194 633699002153 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 633699002154 dimer interface [polypeptide binding]; other site 633699002155 motif 1; other site 633699002156 active site 633699002157 motif 2; other site 633699002158 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 633699002159 putative deacylase active site [active] 633699002160 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 633699002161 active site 633699002162 motif 3; other site 633699002163 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 633699002164 anticodon binding site; other site 633699002165 DNA polymerase III PolC; Validated; Region: polC; PRK00448 633699002166 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 633699002167 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 633699002168 generic binding surface II; other site 633699002169 generic binding surface I; other site 633699002170 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699002171 active site 633699002172 catalytic site [active] 633699002173 substrate binding site [chemical binding]; other site 633699002174 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 633699002175 ribosome maturation protein RimP; Reviewed; Region: PRK00092 633699002176 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 633699002177 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 633699002178 Sm1 motif; other site 633699002179 predicted subunit interaction site [polypeptide binding]; other site 633699002180 RNA binding pocket [nucleotide binding]; other site 633699002181 Sm2 motif; other site 633699002182 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 633699002183 NusA N-terminal domain; Region: NusA_N; pfam08529 633699002184 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 633699002185 RNA binding site [nucleotide binding]; other site 633699002186 homodimer interface [polypeptide binding]; other site 633699002187 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 633699002188 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 633699002189 G-X-X-G motif; other site 633699002190 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 633699002191 putative RNA binding cleft [nucleotide binding]; other site 633699002192 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 633699002193 translation initiation factor IF-2; Validated; Region: infB; PRK05306 633699002194 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633699002195 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633699002196 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 633699002197 G1 box; other site 633699002198 putative GEF interaction site [polypeptide binding]; other site 633699002199 GTP/Mg2+ binding site [chemical binding]; other site 633699002200 Switch I region; other site 633699002201 G2 box; other site 633699002202 G3 box; other site 633699002203 Switch II region; other site 633699002204 G4 box; other site 633699002205 G5 box; other site 633699002206 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 633699002207 Translation-initiation factor 2; Region: IF-2; pfam11987 633699002208 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 633699002209 Ribosome-binding factor A; Region: RBFA; cl00542 633699002210 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 633699002211 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 633699002212 RNA binding site [nucleotide binding]; other site 633699002213 active site 633699002214 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 633699002215 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 633699002216 active site 633699002217 Riboflavin kinase; Region: Flavokinase; cl03312 633699002218 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699002219 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699002220 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699002221 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633699002222 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633699002223 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 633699002224 Helix-turn-helix domains; Region: HTH; cl00088 633699002225 HrcA protein C terminal domain; Region: HrcA; pfam01628 633699002226 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 633699002227 dimer interface [polypeptide binding]; other site 633699002228 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 633699002229 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 633699002230 chaperone protein DnaJ; Provisional; Region: PRK14276 633699002231 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633699002232 HSP70 interaction site [polypeptide binding]; other site 633699002233 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 633699002234 substrate binding site [polypeptide binding]; other site 633699002235 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633699002236 Zn binding sites [ion binding]; other site 633699002237 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633699002238 dimer interface [polypeptide binding]; other site 633699002239 GTP-binding protein LepA; Provisional; Region: PRK05433 633699002240 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 633699002241 G1 box; other site 633699002242 putative GEF interaction site [polypeptide binding]; other site 633699002243 GTP/Mg2+ binding site [chemical binding]; other site 633699002244 Switch I region; other site 633699002245 G2 box; other site 633699002246 G3 box; other site 633699002247 Switch II region; other site 633699002248 G4 box; other site 633699002249 G5 box; other site 633699002250 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 633699002251 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 633699002252 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 633699002253 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 633699002254 active site 633699002255 catalytic site [active] 633699002256 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 633699002257 DHH family; Region: DHH; pfam01368 633699002258 DHHA1 domain; Region: DHHA1; pfam02272 633699002259 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 633699002260 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 633699002261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002262 active site 633699002263 inner membrane transporter YjeM; Provisional; Region: PRK15238 633699002264 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 633699002265 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 633699002266 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 633699002267 putative active site [active] 633699002268 catalytic site [active] 633699002269 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 633699002270 putative active site [active] 633699002271 catalytic site [active] 633699002272 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 633699002273 dimerization interface [polypeptide binding]; other site 633699002274 active site 633699002275 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 633699002276 folate binding site [chemical binding]; other site 633699002277 NADP+ binding site [chemical binding]; other site 633699002278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699002279 MFS/sugar transport protein; Region: MFS_2; pfam13347 633699002280 putative substrate translocation pore; other site 633699002281 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699002282 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 633699002283 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699002285 motif II; other site 633699002286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699002287 Helix-turn-helix domains; Region: HTH; cl00088 633699002288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002289 dimerization interface [polypeptide binding]; other site 633699002290 integrase; Provisional; Region: int; PHA02601 633699002291 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 633699002292 Int/Topo IB signature motif; other site 633699002293 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 633699002294 Domain of unknown function (DUF955); Region: DUF955; cl01076 633699002295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699002296 non-specific DNA binding site [nucleotide binding]; other site 633699002297 salt bridge; other site 633699002298 sequence-specific DNA binding site [nucleotide binding]; other site 633699002299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 633699002300 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 633699002301 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 633699002302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699002304 nucleotide binding region [chemical binding]; other site 633699002305 ATP-binding site [chemical binding]; other site 633699002306 AAA domain; Region: AAA_24; pfam13479 633699002307 Protein of unknown function (DUF669); Region: DUF669; pfam05037 633699002308 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 633699002309 polymerase nucleotide-binding site; other site 633699002310 DNA-binding residues [nucleotide binding]; DNA binding site 633699002311 nucleotide binding site [chemical binding]; other site 633699002312 primase nucleotide-binding site [nucleotide binding]; other site 633699002313 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 633699002314 Virulence-associated protein E; Region: VirE; pfam05272 633699002315 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 633699002316 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 633699002317 Terminase small subunit; Region: Terminase_2; cl01513 633699002318 Phage terminase large subunit; Region: Terminase_3; cl12054 633699002319 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 633699002320 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 633699002321 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 633699002322 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 633699002323 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 633699002324 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 633699002325 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 633699002326 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 633699002327 Phage major tail protein 2; Region: Phage_tail_2; cl11463 633699002328 Phage protein; Region: DUF3647; cl10335 633699002329 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 633699002330 membrane protein P6; Region: PHA01399 633699002331 membrane protein P6; Region: PHA01399 633699002332 membrane protein P6; Region: PHA01399 633699002333 Phage-related protein [Function unknown]; Region: COG4722; cl15832 633699002334 Phage tail protein; Region: Sipho_tail; pfam05709 633699002335 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 633699002336 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 633699002337 gp58-like protein; Region: Gp58; pfam07902 633699002338 gp58-like protein; Region: Gp58; pfam07902 633699002339 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 633699002340 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 633699002341 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 633699002342 active site 633699002343 Bacterial SH3 domain; Region: SH3_3; cl02551 633699002344 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633699002345 active site 633699002346 enolase; Provisional; Region: eno; PRK00077 633699002347 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633699002348 dimer interface [polypeptide binding]; other site 633699002349 metal binding site [ion binding]; metal-binding site 633699002350 substrate binding pocket [chemical binding]; other site 633699002351 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 633699002352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002353 Walker A/P-loop; other site 633699002354 ATP binding site [chemical binding]; other site 633699002355 Q-loop/lid; other site 633699002356 ABC transporter signature motif; other site 633699002357 Walker B; other site 633699002358 D-loop; other site 633699002359 H-loop/switch region; other site 633699002360 ABC transporter; Region: ABC_tran_2; pfam12848 633699002361 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699002362 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 633699002363 active site 633699002364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699002365 non-specific DNA binding site [nucleotide binding]; other site 633699002366 salt bridge; other site 633699002367 sequence-specific DNA binding site [nucleotide binding]; other site 633699002368 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 633699002369 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 633699002370 NMT1-like family; Region: NMT1_2; cl15260 633699002371 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 633699002372 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 633699002373 Walker A/P-loop; other site 633699002374 ATP binding site [chemical binding]; other site 633699002375 Q-loop/lid; other site 633699002376 ABC transporter signature motif; other site 633699002377 Walker B; other site 633699002378 D-loop; other site 633699002379 H-loop/switch region; other site 633699002380 NIL domain; Region: NIL; cl09633 633699002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002382 dimer interface [polypeptide binding]; other site 633699002383 conserved gate region; other site 633699002384 ABC-ATPase subunit interface; other site 633699002385 fumarate hydratase; Reviewed; Region: fumC; PRK00485 633699002386 Class II fumarases; Region: Fumarase_classII; cd01362 633699002387 active site 633699002388 tetramer interface [polypeptide binding]; other site 633699002389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002390 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 633699002391 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 633699002392 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699002393 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699002394 NAD binding site [chemical binding]; other site 633699002395 dimer interface [polypeptide binding]; other site 633699002396 substrate binding site [chemical binding]; other site 633699002397 Uncharacterized conserved protein [Function unknown]; Region: COG2966 633699002398 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 633699002399 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 633699002400 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 633699002401 active site 633699002402 homodimer interface [polypeptide binding]; other site 633699002403 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699002404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002405 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699002406 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 633699002407 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 633699002408 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 633699002409 putative deacylase active site [active] 633699002410 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 633699002411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002412 S-adenosylmethionine binding site [chemical binding]; other site 633699002413 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 633699002414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699002415 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699002416 synthetase active site [active] 633699002417 NTP binding site [chemical binding]; other site 633699002418 metal binding site [ion binding]; metal-binding site 633699002419 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 633699002420 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 633699002421 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 633699002422 putative active site [active] 633699002423 dimerization interface [polypeptide binding]; other site 633699002424 putative tRNAtyr binding site [nucleotide binding]; other site 633699002425 histidyl-tRNA synthetase; Region: hisS; TIGR00442 633699002426 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 633699002427 dimer interface [polypeptide binding]; other site 633699002428 motif 1; other site 633699002429 active site 633699002430 motif 2; other site 633699002431 motif 3; other site 633699002432 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 633699002433 anticodon binding site; other site 633699002434 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 633699002435 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 633699002436 dimer interface [polypeptide binding]; other site 633699002437 anticodon binding site; other site 633699002438 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 633699002439 homodimer interface [polypeptide binding]; other site 633699002440 motif 1; other site 633699002441 active site 633699002442 motif 2; other site 633699002443 GAD domain; Region: GAD; pfam02938 633699002444 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 633699002445 active site 633699002446 motif 3; other site 633699002447 aromatic amino acid aminotransferase; Validated; Region: PRK07309 633699002448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699002449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699002450 homodimer interface [polypeptide binding]; other site 633699002451 catalytic residue [active] 633699002452 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 633699002453 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 633699002454 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 633699002455 active site 633699002456 catalytic triad [active] 633699002457 oxyanion hole [active] 633699002458 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 633699002459 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699002460 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699002461 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 633699002462 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 633699002463 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 633699002464 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 633699002465 Domain of unknown function DUF59; Region: DUF59; cl00941 633699002466 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 633699002467 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 633699002468 GatB domain; Region: GatB_Yqey; cl11497 633699002469 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 633699002470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002471 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 633699002472 GTPase Era; Reviewed; Region: era; PRK00089 633699002473 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 633699002474 G1 box; other site 633699002475 GTP/Mg2+ binding site [chemical binding]; other site 633699002476 Switch I region; other site 633699002477 G2 box; other site 633699002478 Switch II region; other site 633699002479 G3 box; other site 633699002480 G4 box; other site 633699002481 G5 box; other site 633699002482 Recombination protein O N terminal; Region: RecO_N; cl15812 633699002483 DNA repair protein RecO; Region: reco; TIGR00613 633699002484 Recombination protein O C terminal; Region: RecO_C; pfam02565 633699002485 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 633699002486 motif 1; other site 633699002487 dimer interface [polypeptide binding]; other site 633699002488 active site 633699002489 motif 2; other site 633699002490 motif 3; other site 633699002491 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 633699002492 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633699002493 DNA primase; Validated; Region: dnaG; PRK05667 633699002494 CHC2 zinc finger; Region: zf-CHC2; cl15369 633699002495 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 633699002496 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 633699002497 active site 633699002498 metal binding site [ion binding]; metal-binding site 633699002499 interdomain interaction site; other site 633699002500 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 633699002501 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 633699002502 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 633699002503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633699002504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 633699002505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633699002506 DNA binding residues [nucleotide binding] 633699002507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002508 dimer interface [polypeptide binding]; other site 633699002509 conserved gate region; other site 633699002510 putative PBP binding loops; other site 633699002511 ABC-ATPase subunit interface; other site 633699002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699002513 dimer interface [polypeptide binding]; other site 633699002514 conserved gate region; other site 633699002515 putative PBP binding loops; other site 633699002516 ABC-ATPase subunit interface; other site 633699002517 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633699002518 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 633699002519 Walker A/P-loop; other site 633699002520 ATP binding site [chemical binding]; other site 633699002521 Q-loop/lid; other site 633699002522 ABC transporter signature motif; other site 633699002523 Walker B; other site 633699002524 D-loop; other site 633699002525 H-loop/switch region; other site 633699002526 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 633699002527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699002528 substrate binding pocket [chemical binding]; other site 633699002529 membrane-bound complex binding site; other site 633699002530 hinge residues; other site 633699002531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002532 Uncharacterized conserved protein [Function unknown]; Region: COG0327 633699002533 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 633699002534 peptidase T; Region: peptidase-T; TIGR01882 633699002535 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633699002536 metal binding site [ion binding]; metal-binding site 633699002537 dimer interface [polypeptide binding]; other site 633699002538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699002539 DNA-binding site [nucleotide binding]; DNA binding site 633699002540 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 633699002541 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 633699002542 Walker A/P-loop; other site 633699002543 ATP binding site [chemical binding]; other site 633699002544 ABC transporter signature motif; other site 633699002545 Walker B; other site 633699002546 D-loop; other site 633699002547 H-loop/switch region; other site 633699002548 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633699002549 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633699002550 Catalytic site [active] 633699002551 Chitin synthase III catalytic subunit; Region: Chs3p; pfam12271 633699002552 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 633699002553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002554 S-adenosylmethionine binding site [chemical binding]; other site 633699002555 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 633699002556 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 633699002557 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699002558 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 633699002559 sugar phosphate phosphatase; Provisional; Region: PRK10513 633699002560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699002561 active site 633699002562 motif I; other site 633699002563 motif II; other site 633699002564 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699002565 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 633699002566 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 633699002567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002568 active site 633699002569 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 633699002570 active site 633699002571 dimer interface [polypeptide binding]; other site 633699002572 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 633699002573 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 633699002574 heterodimer interface [polypeptide binding]; other site 633699002575 active site 633699002576 FMN binding site [chemical binding]; other site 633699002577 homodimer interface [polypeptide binding]; other site 633699002578 substrate binding site [chemical binding]; other site 633699002579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002580 active site 633699002581 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 633699002582 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633699002583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002584 dihydroorotase; Validated; Region: pyrC; PRK09357 633699002585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633699002586 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 633699002587 active site 633699002588 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 633699002589 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 633699002590 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 633699002591 catalytic site [active] 633699002592 subunit interface [polypeptide binding]; other site 633699002593 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 633699002594 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002595 ATP-grasp domain; Region: ATP-grasp_4; cl03087 633699002596 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 633699002597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002598 ATP-grasp domain; Region: ATP-grasp_4; cl03087 633699002599 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633699002600 IMP binding site; other site 633699002601 dimer interface [polypeptide binding]; other site 633699002602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699002603 active site 633699002604 Isochorismatase family; Region: Isochorismatase; pfam00857 633699002605 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 633699002606 catalytic triad [active] 633699002607 conserved cis-peptide bond; other site 633699002608 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 633699002609 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 633699002610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699002611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699002612 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 633699002613 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 633699002614 active site 633699002615 Zn binding site [ion binding]; other site 633699002616 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002617 FMN binding site [chemical binding]; other site 633699002618 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002619 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633699002620 dimer interface [polypeptide binding]; other site 633699002621 Glycerate kinase family; Region: Gly_kinase; cl00841 633699002622 HTH-like domain; Region: HTH_21; pfam13276 633699002623 Integrase core domain; Region: rve; cl01316 633699002624 Integrase core domain; Region: rve_3; cl15866 633699002625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699002626 Helix-turn-helix domains; Region: HTH; cl00088 633699002627 Helix-turn-helix domains; Region: HTH; cl00088 633699002628 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 633699002629 HflK protein; Region: hflK; TIGR01933 633699002630 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699002632 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 633699002633 Walker A/P-loop; other site 633699002634 ATP binding site [chemical binding]; other site 633699002635 Q-loop/lid; other site 633699002636 ABC transporter signature motif; other site 633699002637 Walker B; other site 633699002638 D-loop; other site 633699002639 H-loop/switch region; other site 633699002640 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699002642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002643 Walker A/P-loop; other site 633699002644 ATP binding site [chemical binding]; other site 633699002645 Q-loop/lid; other site 633699002646 ABC transporter signature motif; other site 633699002647 Walker B; other site 633699002648 D-loop; other site 633699002649 H-loop/switch region; other site 633699002650 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 633699002651 FMN binding site [chemical binding]; other site 633699002652 dimer interface [polypeptide binding]; other site 633699002653 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002654 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699002655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002656 Walker A/P-loop; other site 633699002657 ATP binding site [chemical binding]; other site 633699002658 Q-loop/lid; other site 633699002659 ABC transporter signature motif; other site 633699002660 Walker B; other site 633699002661 D-loop; other site 633699002662 H-loop/switch region; other site 633699002663 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699002664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 633699002665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699002666 Coenzyme A binding pocket [chemical binding]; other site 633699002667 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 633699002668 nucleotide binding site/active site [active] 633699002669 HIT family signature motif; other site 633699002670 catalytic residue [active] 633699002671 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 633699002672 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 633699002673 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699002674 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699002675 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699002676 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 633699002677 nudix motif; other site 633699002678 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633699002679 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633699002680 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 633699002681 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699002682 catalytic core [active] 633699002683 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 633699002684 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633699002685 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633699002686 homodimer interface [polypeptide binding]; other site 633699002687 NADP binding site [chemical binding]; other site 633699002688 substrate binding site [chemical binding]; other site 633699002689 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 633699002690 Sugar transport protein; Region: Sugar_transport; pfam06800 633699002691 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 633699002692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699002693 H+ Antiporter protein; Region: 2A0121; TIGR00900 633699002694 putative substrate translocation pore; other site 633699002695 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699002696 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002698 Walker A/P-loop; other site 633699002699 ATP binding site [chemical binding]; other site 633699002700 Q-loop/lid; other site 633699002701 ABC transporter signature motif; other site 633699002702 Walker B; other site 633699002703 D-loop; other site 633699002704 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699002705 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699002706 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 633699002707 Walker A/P-loop; other site 633699002708 ATP binding site [chemical binding]; other site 633699002709 Q-loop/lid; other site 633699002710 ABC transporter signature motif; other site 633699002711 Walker B; other site 633699002712 D-loop; other site 633699002713 H-loop/switch region; other site 633699002714 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 633699002715 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 633699002716 homotetramer interface [polypeptide binding]; other site 633699002717 FMN binding site [chemical binding]; other site 633699002718 homodimer contacts [polypeptide binding]; other site 633699002719 putative active site [active] 633699002720 putative substrate binding site [chemical binding]; other site 633699002721 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 633699002722 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699002723 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 633699002724 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 633699002725 mevalonate kinase; Region: mevalon_kin; TIGR00549 633699002726 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699002727 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 633699002728 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 633699002729 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 633699002730 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 633699002731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002732 Family description; Region: UvrD_C_2; cl15862 633699002733 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 633699002734 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 633699002735 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699002736 active site 633699002737 catalytic site [active] 633699002738 substrate binding site [chemical binding]; other site 633699002739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002740 ATP binding site [chemical binding]; other site 633699002741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 633699002743 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 633699002744 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 633699002745 putative dimer interface [polypeptide binding]; other site 633699002746 putative anticodon binding site; other site 633699002747 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 633699002748 homodimer interface [polypeptide binding]; other site 633699002749 motif 1; other site 633699002750 motif 2; other site 633699002751 active site 633699002752 motif 3; other site 633699002753 Helix-turn-helix domains; Region: HTH; cl00088 633699002754 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 633699002755 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633699002756 endonuclease III; Region: ENDO3c; smart00478 633699002757 minor groove reading motif; other site 633699002758 helix-hairpin-helix signature motif; other site 633699002759 substrate binding pocket [chemical binding]; other site 633699002760 active site 633699002761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 633699002762 Helix-turn-helix domains; Region: HTH; cl00088 633699002763 Helix-turn-helix domains; Region: HTH; cl00088 633699002764 HTH-like domain; Region: HTH_21; pfam13276 633699002765 Integrase core domain; Region: rve; cl01316 633699002766 Integrase core domain; Region: rve_3; cl15866 633699002767 Transglycosylase; Region: Transgly; cl07896 633699002768 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699002769 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699002770 Recombination protein U; Region: RecU; cl01314 633699002771 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 633699002772 cell division protein GpsB; Provisional; Region: PRK14127 633699002773 DivIVA domain; Region: DivI1A_domain; TIGR03544 633699002774 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 633699002775 THUMP domain; Region: THUMP; cl12076 633699002776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002777 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 633699002778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 633699002779 active site 633699002780 metal binding site [ion binding]; metal-binding site 633699002781 Acyltransferase family; Region: Acyl_transf_3; pfam01757 633699002782 OpgC protein; Region: OpgC_C; cl00792 633699002783 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 633699002784 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 633699002785 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 633699002786 Potassium binding sites [ion binding]; other site 633699002787 Cesium cation binding sites [ion binding]; other site 633699002788 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 633699002789 lipoprotein signal peptidase; Provisional; Region: PRK14787 633699002790 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 633699002791 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699002792 RNA binding surface [nucleotide binding]; other site 633699002793 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 633699002794 active site 633699002795 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 633699002796 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 633699002797 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 633699002798 conserved cys residue [active] 633699002799 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 633699002800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002801 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 633699002802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633699002803 ATP-grasp domain; Region: ATP-grasp_4; cl03087 633699002804 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633699002805 IMP binding site; other site 633699002806 dimer interface [polypeptide binding]; other site 633699002807 interdomain contacts; other site 633699002808 partial ornithine binding site; other site 633699002809 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 633699002810 Domain of unknown function (DUF814); Region: DUF814; pfam05670 633699002811 Helix-turn-helix domains; Region: HTH; cl00088 633699002812 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 633699002813 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 633699002814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002815 Helix-turn-helix domains; Region: HTH; cl00088 633699002816 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 633699002817 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699002818 active site 633699002819 DNA binding site [nucleotide binding] 633699002820 Int/Topo IB signature motif; other site 633699002821 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 633699002822 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 633699002823 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 633699002824 active site 633699002825 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 633699002826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002827 ATP binding site [chemical binding]; other site 633699002828 putative Mg++ binding site [ion binding]; other site 633699002829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699002830 nucleotide binding region [chemical binding]; other site 633699002831 ATP-binding site [chemical binding]; other site 633699002832 RQC domain; Region: RQC; cl09632 633699002833 HRDC domain; Region: HRDC; cl02578 633699002834 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 633699002835 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 633699002836 DHHA2 domain; Region: DHHA2; pfam02833 633699002837 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 633699002838 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 633699002839 CAP-like domain; other site 633699002840 active site 633699002841 primary dimer interface [polypeptide binding]; other site 633699002842 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699002843 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633699002844 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 633699002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 633699002846 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633699002847 anchoring element; other site 633699002848 dimer interface [polypeptide binding]; other site 633699002849 ATP binding site [chemical binding]; other site 633699002850 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633699002851 active site 633699002852 putative metal-binding site [ion binding]; other site 633699002853 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633699002854 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 633699002855 maltose O-acetyltransferase; Provisional; Region: PRK10092 633699002856 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 633699002857 active site 633699002858 substrate binding site [chemical binding]; other site 633699002859 trimer interface [polypeptide binding]; other site 633699002860 CoA binding site [chemical binding]; other site 633699002861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699002862 active site 633699002863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 633699002864 catalytic tetrad [active] 633699002865 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 633699002866 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 633699002867 recombination factor protein RarA; Reviewed; Region: PRK13342 633699002868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699002869 Walker A motif; other site 633699002870 ATP binding site [chemical binding]; other site 633699002871 Walker B motif; other site 633699002872 arginine finger; other site 633699002873 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633699002874 TIGR02687 family protein; Region: TIGR02687 633699002875 PglZ domain; Region: PglZ; pfam08665 633699002876 hypothetical protein; Provisional; Region: PRK06194 633699002877 classical (c) SDRs; Region: SDR_c; cd05233 633699002878 NAD(P) binding site [chemical binding]; other site 633699002879 active site 633699002880 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 633699002881 dimer interface [polypeptide binding]; other site 633699002882 FMN binding site [chemical binding]; other site 633699002883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699002884 Helix-turn-helix domains; Region: HTH; cl00088 633699002885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699002886 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 633699002887 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 633699002888 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 633699002889 recombination factor protein RarA; Reviewed; Region: PRK13342 633699002890 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 633699002891 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633699002892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699002893 Coenzyme A binding pocket [chemical binding]; other site 633699002894 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699002895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 633699002896 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 633699002897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699002898 ATP binding site [chemical binding]; other site 633699002899 putative Mg++ binding site [ion binding]; other site 633699002900 Protein of unknown function DUF262; Region: DUF262; cl14890 633699002901 Protein of unknown function DUF262; Region: DUF262; cl14890 633699002902 Protein of unknown function DUF262; Region: DUF262; cl14890 633699002903 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 633699002904 Interdomain contacts; other site 633699002905 Cytokine receptor motif; other site 633699002906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699002907 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699002908 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 633699002909 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699002910 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699002911 Cupin domain; Region: Cupin_2; cl09118 633699002912 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 633699002913 dimer interface [polypeptide binding]; other site 633699002914 catalytic triad [active] 633699002915 peroxidatic and resolving cysteines [active] 633699002916 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 633699002917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 633699002918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002919 Walker A/P-loop; other site 633699002920 ATP binding site [chemical binding]; other site 633699002921 Q-loop/lid; other site 633699002922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002923 ABC transporter signature motif; other site 633699002924 Walker B; other site 633699002925 D-loop; other site 633699002926 H-loop/switch region; other site 633699002927 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002928 AAA domain; Region: AAA_21; pfam13304 633699002929 Walker A/P-loop; other site 633699002930 ATP binding site [chemical binding]; other site 633699002931 Q-loop/lid; other site 633699002932 ABC transporter signature motif; other site 633699002933 Walker B; other site 633699002934 D-loop; other site 633699002935 H-loop/switch region; other site 633699002936 NTP-binding motif containing protein; Region: PHA00729 633699002937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699002938 Walker A motif; other site 633699002939 ATP binding site [chemical binding]; other site 633699002940 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 633699002941 active site 633699002942 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 633699002943 active site 633699002944 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633699002945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699002946 S-adenosylmethionine binding site [chemical binding]; other site 633699002947 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 633699002948 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 633699002949 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 633699002950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002951 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 633699002952 aromatic amino acid aminotransferase; Validated; Region: PRK07309 633699002953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699002954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699002955 homodimer interface [polypeptide binding]; other site 633699002956 catalytic residue [active] 633699002957 dihydrodipicolinate reductase; Provisional; Region: PRK00048 633699002958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699002959 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 633699002960 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 633699002961 dihydrodipicolinate synthase; Region: dapA; TIGR00674 633699002962 dimer interface [polypeptide binding]; other site 633699002963 active site 633699002964 catalytic residue [active] 633699002965 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 633699002966 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 633699002967 metal binding site [ion binding]; metal-binding site 633699002968 putative dimer interface [polypeptide binding]; other site 633699002969 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 633699002970 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 633699002971 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 633699002972 putative trimer interface [polypeptide binding]; other site 633699002973 putative CoA binding site [chemical binding]; other site 633699002974 diaminopimelate decarboxylase; Region: lysA; TIGR01048 633699002975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 633699002976 active site 633699002977 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633699002978 substrate binding site [chemical binding]; other site 633699002979 catalytic residues [active] 633699002980 dimer interface [polypeptide binding]; other site 633699002981 aspartate kinase; Reviewed; Region: PRK09034 633699002982 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 633699002983 putative catalytic residues [active] 633699002984 putative nucleotide binding site [chemical binding]; other site 633699002985 putative aspartate binding site [chemical binding]; other site 633699002986 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 633699002987 allosteric regulatory residue; other site 633699002988 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 633699002989 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 633699002990 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 633699002991 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 633699002992 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699002993 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699002994 Transposase; Region: DEDD_Tnp_IS110; pfam01548 633699002995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 633699002996 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 633699002997 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 633699002998 MucBP domain; Region: MucBP; pfam06458 633699002999 MucBP domain; Region: MucBP; pfam06458 633699003000 MucBP domain; Region: MucBP; pfam06458 633699003001 MucBP domain; Region: MucBP; pfam06458 633699003002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699003003 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003004 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 633699003005 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 633699003006 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699003009 dimer interface [polypeptide binding]; other site 633699003010 phosphorylation site [posttranslational modification] 633699003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699003012 Mg2+ binding site [ion binding]; other site 633699003013 G-X-G motif; other site 633699003014 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 633699003015 Response regulator receiver domain; Region: Response_reg; pfam00072 633699003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699003017 active site 633699003018 phosphorylation site [posttranslational modification] 633699003019 intermolecular recognition site; other site 633699003020 dimerization interface [polypeptide binding]; other site 633699003021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699003022 DNA binding site [nucleotide binding] 633699003023 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 633699003024 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 633699003025 nudix motif; other site 633699003026 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 633699003027 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699003028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699003029 active site 633699003030 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 633699003031 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 633699003032 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 633699003033 acetolactate synthase; Reviewed; Region: PRK08617 633699003034 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 633699003035 PYR/PP interface [polypeptide binding]; other site 633699003036 dimer interface [polypeptide binding]; other site 633699003037 TPP binding site [chemical binding]; other site 633699003038 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 633699003039 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 633699003040 TPP-binding site [chemical binding]; other site 633699003041 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 633699003042 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699003043 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699003044 ABC transporter; Region: ABC_tran_2; pfam12848 633699003045 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699003046 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 633699003047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 633699003048 Probable transposase; Region: OrfB_IS605; pfam01385 633699003049 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 633699003050 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 633699003051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699003052 dimerization interface [polypeptide binding]; other site 633699003053 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 633699003054 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 633699003055 active site 633699003056 catalytic residues [active] 633699003057 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 633699003058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003059 Walker A motif; other site 633699003060 ATP binding site [chemical binding]; other site 633699003061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699003062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 633699003063 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 633699003064 active site 633699003065 HslU subunit interaction site [polypeptide binding]; other site 633699003066 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633699003067 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 633699003068 active site 633699003069 Int/Topo IB signature motif; other site 633699003070 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 633699003071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003072 DNA topoisomerase I; Validated; Region: PRK05582 633699003073 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 633699003074 active site 633699003075 interdomain interaction site; other site 633699003076 putative metal-binding site [ion binding]; other site 633699003077 nucleotide binding site [chemical binding]; other site 633699003078 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 633699003079 domain I; other site 633699003080 DNA binding groove [nucleotide binding] 633699003081 phosphate binding site [ion binding]; other site 633699003082 domain II; other site 633699003083 domain III; other site 633699003084 nucleotide binding site [chemical binding]; other site 633699003085 catalytic site [active] 633699003086 domain IV; other site 633699003087 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633699003088 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633699003089 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 633699003090 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 633699003091 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 633699003092 RNA/DNA hybrid binding site [nucleotide binding]; other site 633699003093 active site 633699003094 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 633699003095 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 633699003096 GTP/Mg2+ binding site [chemical binding]; other site 633699003097 G4 box; other site 633699003098 G5 box; other site 633699003099 G1 box; other site 633699003100 Switch I region; other site 633699003101 G2 box; other site 633699003102 G3 box; other site 633699003103 Switch II region; other site 633699003104 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 633699003105 C-terminal peptidase (prc); Region: prc; TIGR00225 633699003106 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 633699003107 protein binding site [polypeptide binding]; other site 633699003108 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 633699003109 Catalytic dyad [active] 633699003110 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 633699003111 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 633699003112 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 633699003113 Haemolysin-III related; Region: HlyIII; cl03831 633699003114 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 633699003115 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 633699003116 active site 633699003117 NTP binding site [chemical binding]; other site 633699003118 metal binding triad [ion binding]; metal-binding site 633699003119 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 633699003120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699003121 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633699003122 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699003123 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633699003124 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 633699003125 UbiA prenyltransferase family; Region: UbiA; cl00337 633699003126 hypothetical protein; Validated; Region: PRK07121 633699003127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633699003128 Helix-turn-helix domains; Region: HTH; cl00088 633699003129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633699003130 dimerization interface [polypeptide binding]; other site 633699003131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 633699003132 Transposase; Region: DDE_Tnp_ISL3; pfam01610 633699003133 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 633699003134 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 633699003135 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 633699003136 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 633699003137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003138 ATP binding site [chemical binding]; other site 633699003139 putative Mg++ binding site [ion binding]; other site 633699003140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 633699003142 binding surface 633699003143 TPR motif; other site 633699003144 TPR repeat; Region: TPR_11; pfam13414 633699003145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633699003146 binding surface 633699003147 TPR motif; other site 633699003148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 633699003149 binding surface 633699003150 TPR motif; other site 633699003151 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 633699003152 IHF dimer interface [polypeptide binding]; other site 633699003153 IHF - DNA interface [nucleotide binding]; other site 633699003154 GTP-binding protein Der; Reviewed; Region: PRK00093 633699003155 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 633699003156 G1 box; other site 633699003157 GTP/Mg2+ binding site [chemical binding]; other site 633699003158 Switch I region; other site 633699003159 G2 box; other site 633699003160 Switch II region; other site 633699003161 G3 box; other site 633699003162 G4 box; other site 633699003163 G5 box; other site 633699003164 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 633699003165 G1 box; other site 633699003166 GTP/Mg2+ binding site [chemical binding]; other site 633699003167 Switch I region; other site 633699003168 G2 box; other site 633699003169 G3 box; other site 633699003170 Switch II region; other site 633699003171 G4 box; other site 633699003172 G5 box; other site 633699003173 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 633699003174 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 633699003175 RNA binding site [nucleotide binding]; other site 633699003176 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699003177 RNA binding site [nucleotide binding]; other site 633699003178 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 633699003179 RNA binding site [nucleotide binding]; other site 633699003180 cytidylate kinase; Provisional; Region: cmk; PRK00023 633699003181 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 633699003182 CMP-binding site; other site 633699003183 The sites determining sugar specificity; other site 633699003184 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 633699003185 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 633699003186 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 633699003187 putative peptidoglycan binding site; other site 633699003188 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633699003189 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003190 RNA binding surface [nucleotide binding]; other site 633699003191 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 633699003192 active site 633699003193 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 633699003194 ScpA/B protein; Region: ScpA_ScpB; cl00598 633699003195 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633699003196 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 633699003197 active site 633699003198 Int/Topo IB signature motif; other site 633699003199 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 633699003200 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699003201 pyruvate kinase; Provisional; Region: PRK06354 633699003202 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 633699003203 domain interfaces; other site 633699003204 active site 633699003205 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 633699003206 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 633699003207 active site 633699003208 ADP/pyrophosphate binding site [chemical binding]; other site 633699003209 dimerization interface [polypeptide binding]; other site 633699003210 allosteric effector site; other site 633699003211 fructose-1,6-bisphosphate binding site; other site 633699003212 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 633699003213 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 633699003214 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 633699003215 generic binding surface II; other site 633699003216 generic binding surface I; other site 633699003217 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 633699003218 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 633699003219 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 633699003220 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 633699003221 active site 633699003222 metal binding site [ion binding]; metal-binding site 633699003223 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 633699003224 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 633699003225 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 633699003226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003227 NAD(P) binding site [chemical binding]; other site 633699003228 active site 633699003229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699003230 OpgC protein; Region: OpgC_C; cl00792 633699003231 Acyltransferase family; Region: Acyl_transf_3; pfam01757 633699003232 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 633699003233 catalytic triad [active] 633699003234 catalytic triad [active] 633699003235 oxyanion hole [active] 633699003236 GTPase CgtA; Reviewed; Region: obgE; PRK12297 633699003237 GTP1/OBG; Region: GTP1_OBG; pfam01018 633699003238 Obg GTPase; Region: Obg; cd01898 633699003239 G1 box; other site 633699003240 GTP/Mg2+ binding site [chemical binding]; other site 633699003241 Switch I region; other site 633699003242 G2 box; other site 633699003243 G3 box; other site 633699003244 Switch II region; other site 633699003245 G4 box; other site 633699003246 G5 box; other site 633699003247 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 633699003248 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 633699003249 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 633699003250 GIY-YIG motif/motif A; other site 633699003251 active site 633699003252 catalytic site [active] 633699003253 putative DNA binding site [nucleotide binding]; other site 633699003254 metal binding site [ion binding]; metal-binding site 633699003255 UvrB/uvrC motif; Region: UVR; pfam02151 633699003256 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 633699003257 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 633699003258 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 633699003259 active site 633699003260 dimerization interface [polypeptide binding]; other site 633699003261 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633699003262 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 633699003263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003264 NAD(P) binding site [chemical binding]; other site 633699003265 active site 633699003266 amino acid transporter; Region: 2A0306; TIGR00909 633699003267 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 633699003268 Rib/alpha-like repeat; Region: Rib; cl07159 633699003269 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 633699003270 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 633699003271 putative active site [active] 633699003272 nucleotide binding site [chemical binding]; other site 633699003273 nudix motif; other site 633699003274 putative metal binding site [ion binding]; other site 633699003275 Bacterial SH3 domain; Region: SH3_3; cl02551 633699003276 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 633699003277 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 633699003278 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 633699003279 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 633699003280 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 633699003281 Int/Topo IB signature motif; other site 633699003282 Peptidase family M48; Region: Peptidase_M48; cl12018 633699003283 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 633699003284 putative active site [active] 633699003285 putative NTP binding site [chemical binding]; other site 633699003286 putative nucleic acid binding site [nucleotide binding]; other site 633699003287 Integrase core domain; Region: rve; cl01316 633699003288 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 633699003289 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 633699003290 MatE; Region: MatE; cl10513 633699003291 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 633699003292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003293 UDP-galactopyranose mutase; Region: GLF; pfam03275 633699003294 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 633699003295 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699003296 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 633699003297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699003298 active site 633699003299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699003300 active site 633699003301 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699003302 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 633699003303 putative ADP-binding pocket [chemical binding]; other site 633699003304 Bacterial sugar transferase; Region: Bac_transf; cl00939 633699003305 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 633699003306 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 633699003307 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 633699003308 Nucleotide binding site [chemical binding]; other site 633699003309 Chain length determinant protein; Region: Wzz; cl15801 633699003310 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 633699003311 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699003312 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633699003313 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 633699003314 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633699003315 Low molecular weight phosphatase family; Region: LMWPc; cd00115 633699003316 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 633699003317 active site 633699003318 Predicted GTPase [General function prediction only]; Region: COG0218 633699003319 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 633699003320 G1 box; other site 633699003321 GTP/Mg2+ binding site [chemical binding]; other site 633699003322 Switch I region; other site 633699003323 G2 box; other site 633699003324 G3 box; other site 633699003325 Switch II region; other site 633699003326 G4 box; other site 633699003327 G5 box; other site 633699003328 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 633699003329 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 633699003330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003331 Walker A motif; other site 633699003332 ATP binding site [chemical binding]; other site 633699003333 Walker B motif; other site 633699003334 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 633699003335 trigger factor; Provisional; Region: tig; PRK01490 633699003336 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 633699003337 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633699003338 elongation factor Tu; Reviewed; Region: PRK00049 633699003339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 633699003340 G1 box; other site 633699003341 GEF interaction site [polypeptide binding]; other site 633699003342 GTP/Mg2+ binding site [chemical binding]; other site 633699003343 Switch I region; other site 633699003344 G2 box; other site 633699003345 G3 box; other site 633699003346 Switch II region; other site 633699003347 G4 box; other site 633699003348 G5 box; other site 633699003349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 633699003350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 633699003351 Antibiotic Binding Site [chemical binding]; other site 633699003352 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699003353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699003354 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699003355 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 633699003356 16S/18S rRNA binding site [nucleotide binding]; other site 633699003357 S13e-L30e interaction site [polypeptide binding]; other site 633699003358 25S rRNA binding site [nucleotide binding]; other site 633699003359 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 633699003360 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 633699003361 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 633699003362 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 633699003363 Competence protein; Region: Competence; cl00471 633699003364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699003365 SLBB domain; Region: SLBB; pfam10531 633699003366 comEA protein; Region: comE; TIGR01259 633699003367 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 633699003368 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 633699003369 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 633699003370 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 633699003371 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 633699003372 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 633699003373 active site 633699003374 (T/H)XGH motif; other site 633699003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699003376 S-adenosylmethionine binding site [chemical binding]; other site 633699003377 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 633699003378 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 633699003379 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 633699003380 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 633699003381 putative GEF interaction site [polypeptide binding]; other site 633699003382 G1 box; other site 633699003383 GTP/Mg2+ binding site [chemical binding]; other site 633699003384 Switch I region; other site 633699003385 G2 box; other site 633699003386 G3 box; other site 633699003387 Switch II region; other site 633699003388 G4 box; other site 633699003389 G5 box; other site 633699003390 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 633699003391 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 633699003392 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633699003393 active site 633699003394 catalytic residues [active] 633699003395 metal binding site [ion binding]; metal-binding site 633699003396 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 633699003397 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699003398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699003399 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699003400 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 633699003401 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 633699003402 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 633699003403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699003404 Family description; Region: UvrD_C_2; cl15862 633699003405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 633699003406 binding surface 633699003407 TPR motif; other site 633699003408 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 633699003409 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699003410 catalytic core [active] 633699003411 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 633699003412 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 633699003413 Putative amino acid metabolism; Region: DUF1831; pfam08866 633699003414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633699003415 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 633699003416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699003417 catalytic residue [active] 633699003418 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633699003419 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 633699003420 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 633699003421 dimer interface [polypeptide binding]; other site 633699003422 ADP-ribose binding site [chemical binding]; other site 633699003423 active site 633699003424 nudix motif; other site 633699003425 metal binding site [ion binding]; metal-binding site 633699003426 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 633699003427 DNA-binding site [nucleotide binding]; DNA binding site 633699003428 RNA-binding motif; other site 633699003429 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 633699003430 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699003431 active site 633699003432 HIGH motif; other site 633699003433 nucleotide binding site [chemical binding]; other site 633699003434 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 633699003435 active site 633699003436 KMSKS motif; other site 633699003437 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 633699003438 tRNA binding surface [nucleotide binding]; other site 633699003439 anticodon binding site; other site 633699003440 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 633699003441 DivIVA domain; Region: DivI1A_domain; TIGR03544 633699003442 Plant ATP synthase F0; Region: YMF19; cl07975 633699003443 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 633699003444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003445 RNA binding surface [nucleotide binding]; other site 633699003446 YGGT family; Region: YGGT; cl00508 633699003447 Protein of unknown function (DUF552); Region: DUF552; cl00775 633699003448 cell division protein FtsZ; Validated; Region: PRK09330 633699003449 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 633699003450 nucleotide binding site [chemical binding]; other site 633699003451 SulA interaction site; other site 633699003452 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 633699003453 Cell division protein FtsA; Region: FtsA; cl11496 633699003454 Cell division protein FtsA; Region: FtsA; cl11496 633699003455 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 633699003456 Cell division protein FtsQ; Region: FtsQ; pfam03799 633699003457 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 633699003458 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 633699003459 active site 633699003460 homodimer interface [polypeptide binding]; other site 633699003461 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 633699003462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699003464 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 633699003465 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 633699003466 Mg++ binding site [ion binding]; other site 633699003467 putative catalytic motif [active] 633699003468 putative substrate binding site [chemical binding]; other site 633699003469 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 633699003470 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633699003471 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699003472 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 633699003473 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 633699003474 Septum formation initiator; Region: DivIC; cl11433 633699003475 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 633699003476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003477 cell division protein MraZ; Reviewed; Region: PRK00326 633699003478 MraZ protein; Region: MraZ; pfam02381 633699003479 MraZ protein; Region: MraZ; pfam02381 633699003480 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 633699003481 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 633699003482 rod shape-determining protein MreD; Region: MreD; cl01087 633699003483 rod shape-determining protein MreC; Region: MreC; pfam04085 633699003484 rod shape-determining protein MreB; Provisional; Region: PRK13927 633699003485 Cell division protein FtsA; Region: FtsA; cl11496 633699003486 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 633699003487 MPN+ (JAMM) motif; other site 633699003488 Zinc-binding site [ion binding]; other site 633699003489 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 633699003490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003491 motif II; other site 633699003492 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 633699003493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699003495 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 633699003496 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699003497 active site 633699003498 HIGH motif; other site 633699003499 nucleotide binding site [chemical binding]; other site 633699003500 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633699003501 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 633699003502 active site 633699003503 KMSKS motif; other site 633699003504 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 633699003505 tRNA binding surface [nucleotide binding]; other site 633699003506 anticodon binding site; other site 633699003507 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 633699003508 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699003509 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699003510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699003511 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699003512 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699003513 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699003514 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699003515 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 633699003516 active site 633699003517 catalytic site [active] 633699003518 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633699003519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003520 RNA binding surface [nucleotide binding]; other site 633699003521 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 633699003522 active site 633699003523 uracil binding [chemical binding]; other site 633699003524 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 633699003525 THUMP domain; Region: THUMP; cl12076 633699003526 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 633699003527 Ligand Binding Site [chemical binding]; other site 633699003528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633699003529 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 633699003530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699003531 catalytic residue [active] 633699003532 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 633699003533 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 633699003534 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 633699003535 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 633699003536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633699003537 RNA binding surface [nucleotide binding]; other site 633699003538 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 633699003539 recombination factor protein RarA; Reviewed; Region: PRK13342 633699003540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003541 Walker A motif; other site 633699003542 ATP binding site [chemical binding]; other site 633699003543 Walker B motif; other site 633699003544 arginine finger; other site 633699003545 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633699003546 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633699003547 Ligand Binding Site [chemical binding]; other site 633699003548 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 633699003549 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 633699003550 Haemolytic domain; Region: Haemolytic; cl00506 633699003551 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 633699003552 rod shape-determining protein MreB; Provisional; Region: PRK13930 633699003553 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 633699003554 Cell division protein FtsA; Region: FtsA; cl11496 633699003555 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 633699003556 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 633699003557 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 633699003558 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 633699003559 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 633699003560 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 633699003561 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 633699003562 alpha subunit interaction interface [polypeptide binding]; other site 633699003563 Walker A motif; other site 633699003564 ATP binding site [chemical binding]; other site 633699003565 Walker B motif; other site 633699003566 inhibitor binding site; inhibition site 633699003567 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633699003568 ATP synthase; Region: ATP-synt; cl00365 633699003569 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 633699003570 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 633699003571 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 633699003572 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 633699003573 beta subunit interaction interface [polypeptide binding]; other site 633699003574 Walker A motif; other site 633699003575 ATP binding site [chemical binding]; other site 633699003576 Walker B motif; other site 633699003577 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633699003578 Plant ATP synthase F0; Region: YMF19; cl07975 633699003579 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 633699003580 Plant ATP synthase F0; Region: YMF19; cl07975 633699003581 ATP synthase subunit C; Region: ATP-synt_C; cl00466 633699003582 ATP synthase A chain; Region: ATP-synt_A; cl00413 633699003583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699003584 active site 633699003585 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 633699003586 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 633699003587 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 633699003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699003589 S-adenosylmethionine binding site [chemical binding]; other site 633699003590 peptide chain release factor 1; Validated; Region: prfA; PRK00591 633699003591 RF-1 domain; Region: RF-1; cl02875 633699003592 RF-1 domain; Region: RF-1; cl02875 633699003593 thymidine kinase; Provisional; Region: PRK04296 633699003594 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 633699003595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699003596 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 633699003597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699003598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 633699003599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 633699003600 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 633699003601 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 633699003602 active site 633699003603 dimer interface [polypeptide binding]; other site 633699003604 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 633699003605 dimer interface [polypeptide binding]; other site 633699003606 active site 633699003607 VanZ like family; Region: VanZ; cl01971 633699003608 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 633699003609 Sulfatase; Region: Sulfatase; cl10460 633699003610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 633699003611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633699003612 dimerization interface [polypeptide binding]; other site 633699003613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699003614 dimer interface [polypeptide binding]; other site 633699003615 phosphorylation site [posttranslational modification] 633699003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699003617 ATP binding site [chemical binding]; other site 633699003618 Mg2+ binding site [ion binding]; other site 633699003619 G-X-G motif; other site 633699003620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699003621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699003622 active site 633699003623 phosphorylation site [posttranslational modification] 633699003624 intermolecular recognition site; other site 633699003625 dimerization interface [polypeptide binding]; other site 633699003626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699003627 DNA binding site [nucleotide binding] 633699003628 SdpI/YhfL protein family; Region: SdpI; pfam13630 633699003629 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 633699003630 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 633699003631 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 633699003632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633699003633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633699003634 homodimer interface [polypeptide binding]; other site 633699003635 catalytic residue [active] 633699003636 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 633699003637 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 633699003638 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 633699003639 active site 633699003640 Acetokinase family; Region: Acetate_kinase; cl01029 633699003641 propionate/acetate kinase; Provisional; Region: PRK12379 633699003642 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 633699003643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003644 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 633699003645 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 633699003646 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 633699003647 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 633699003648 Type II/IV secretion system protein; Region: T2SE; pfam00437 633699003649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699003650 Walker A motif; other site 633699003651 ATP binding site [chemical binding]; other site 633699003652 Walker B motif; other site 633699003653 Transcriptional regulator; Region: Transcrip_reg; cl00361 633699003654 VanZ like family; Region: VanZ; cl01971 633699003655 Flavoprotein; Region: Flavoprotein; cl08021 633699003656 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 633699003657 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 633699003658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 633699003659 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 633699003660 intersubunit interface [polypeptide binding]; other site 633699003661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699003662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633699003663 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 633699003664 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003665 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003666 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 633699003667 CrcB-like protein; Region: CRCB; cl09114 633699003668 CrcB-like protein; Region: CRCB; cl09114 633699003669 sugar phosphate phosphatase; Provisional; Region: PRK10513 633699003670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003671 active site 633699003672 motif I; other site 633699003673 motif II; other site 633699003674 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 633699003675 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 633699003676 active site 633699003677 substrate binding site [chemical binding]; other site 633699003678 metal binding site [ion binding]; metal-binding site 633699003679 YbbR-like protein; Region: YbbR; pfam07949 633699003680 YbbR-like protein; Region: YbbR; pfam07949 633699003681 YbbR-like protein; Region: YbbR; pfam07949 633699003682 Uncharacterized conserved protein [Function unknown]; Region: COG1624 633699003683 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 633699003684 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 633699003685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699003686 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 633699003687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699003688 dimer interface [polypeptide binding]; other site 633699003689 ABC-ATPase subunit interface; other site 633699003690 putative PBP binding loops; other site 633699003691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699003692 dimer interface [polypeptide binding]; other site 633699003693 conserved gate region; other site 633699003694 putative PBP binding loops; other site 633699003695 ABC-ATPase subunit interface; other site 633699003696 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 633699003697 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 633699003698 Walker A/P-loop; other site 633699003699 ATP binding site [chemical binding]; other site 633699003700 Q-loop/lid; other site 633699003701 ABC transporter signature motif; other site 633699003702 Walker B; other site 633699003703 D-loop; other site 633699003704 H-loop/switch region; other site 633699003705 TOBE domain; Region: TOBE_2; cl01440 633699003706 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 633699003707 FAD binding domain; Region: FAD_binding_4; pfam01565 633699003708 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 633699003709 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 633699003710 active site 633699003711 catalytic site [active] 633699003712 substrate binding site [chemical binding]; other site 633699003713 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 633699003714 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 633699003715 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 633699003716 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 633699003717 ligand binding site [chemical binding]; other site 633699003718 active site 633699003719 UGI interface [polypeptide binding]; other site 633699003720 catalytic site [active] 633699003721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003722 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699003723 active site 633699003724 motif I; other site 633699003725 motif II; other site 633699003726 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699003727 Scramblase; Region: Scramblase; cl02043 633699003728 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 633699003729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699003730 Coenzyme A binding pocket [chemical binding]; other site 633699003731 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 633699003732 SmpB-tmRNA interface; other site 633699003733 ribonuclease R; Region: RNase_R; TIGR02063 633699003734 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699003735 RNB domain; Region: RNB; pfam00773 633699003736 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 633699003737 RNA binding site [nucleotide binding]; other site 633699003738 Preprotein translocase SecG subunit; Region: SecG; cl09123 633699003739 enolase; Provisional; Region: eno; PRK00077 633699003740 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633699003741 dimer interface [polypeptide binding]; other site 633699003742 metal binding site [ion binding]; metal-binding site 633699003743 substrate binding pocket [chemical binding]; other site 633699003744 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 633699003745 substrate binding site [chemical binding]; other site 633699003746 dimer interface [polypeptide binding]; other site 633699003747 catalytic triad [active] 633699003748 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 633699003749 Phosphoglycerate kinase; Region: PGK; pfam00162 633699003750 substrate binding site [chemical binding]; other site 633699003751 hinge regions; other site 633699003752 ADP binding site [chemical binding]; other site 633699003753 catalytic site [active] 633699003754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003755 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 633699003756 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 633699003757 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 633699003758 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 633699003759 Amino acid permease; Region: AA_permease_2; pfam13520 633699003760 Clp protease; Region: CLP_protease; pfam00574 633699003761 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 633699003762 oligomer interface [polypeptide binding]; other site 633699003763 active site residues [active] 633699003764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 633699003765 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 633699003766 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 633699003767 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 633699003768 phosphate binding site [ion binding]; other site 633699003769 putative substrate binding pocket [chemical binding]; other site 633699003770 dimer interface [polypeptide binding]; other site 633699003771 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 633699003772 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 633699003773 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 633699003774 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 633699003775 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 633699003776 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 633699003777 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 633699003778 excinuclease ABC subunit B; Provisional; Region: PRK05298 633699003779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003780 ATP-binding site [chemical binding]; other site 633699003781 ATP binding site [chemical binding]; other site 633699003782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003783 nucleotide binding region [chemical binding]; other site 633699003784 ATP-binding site [chemical binding]; other site 633699003785 Ultra-violet resistance protein B; Region: UvrB; pfam12344 633699003786 UvrB/uvrC motif; Region: UVR; pfam02151 633699003787 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 633699003788 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 633699003789 active site 633699003790 substrate binding site [chemical binding]; other site 633699003791 metal binding site [ion binding]; metal-binding site 633699003792 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 633699003793 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 633699003794 catalytic residues [active] 633699003795 catalytic residues [active] 633699003796 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 633699003797 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 633699003798 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 633699003799 galactokinase; Provisional; Region: PRK05322 633699003800 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 633699003801 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633699003802 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699003803 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699003804 DNA binding site [nucleotide binding] 633699003805 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 633699003806 putative ligand binding site [chemical binding]; other site 633699003807 putative dimerization interface [polypeptide binding]; other site 633699003808 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 633699003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699003811 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 633699003812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003813 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 633699003814 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 633699003815 HPr kinase/phosphorylase; Provisional; Region: PRK05428 633699003816 DRTGG domain; Region: DRTGG; cl12147 633699003817 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 633699003818 Hpr binding site; other site 633699003819 active site 633699003820 homohexamer subunit interaction site [polypeptide binding]; other site 633699003821 peptide chain release factor 2; Provisional; Region: PRK05589 633699003822 RF-1 domain; Region: RF-1; cl02875 633699003823 RF-1 domain; Region: RF-1; cl02875 633699003824 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 633699003825 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 633699003826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003827 nucleotide binding region [chemical binding]; other site 633699003828 ATP-binding site [chemical binding]; other site 633699003829 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 633699003830 30S subunit binding site; other site 633699003831 comF family protein; Region: comF; TIGR00201 633699003832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633699003833 active site 633699003834 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633699003835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699003836 ATP binding site [chemical binding]; other site 633699003837 putative Mg++ binding site [ion binding]; other site 633699003838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699003839 nucleotide binding region [chemical binding]; other site 633699003840 ATP-binding site [chemical binding]; other site 633699003841 Uncharacterized conserved protein [Function unknown]; Region: COG1739 633699003842 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 633699003843 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 633699003844 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 633699003845 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 633699003846 Mg++ binding site [ion binding]; other site 633699003847 putative catalytic motif [active] 633699003848 substrate binding site [chemical binding]; other site 633699003849 phosphodiesterase; Provisional; Region: PRK12704 633699003850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699003851 recombinase A; Provisional; Region: recA; PRK09354 633699003852 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 633699003853 hexamer interface [polypeptide binding]; other site 633699003854 Walker A motif; other site 633699003855 ATP binding site [chemical binding]; other site 633699003856 Walker B motif; other site 633699003857 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 633699003858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 633699003859 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 633699003860 classical (c) SDRs; Region: SDR_c; cd05233 633699003861 NAD(P) binding site [chemical binding]; other site 633699003862 active site 633699003863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 633699003864 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 633699003865 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633699003866 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 633699003867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633699003868 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 633699003869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699003870 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 633699003871 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 633699003872 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 633699003873 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633699003874 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 633699003875 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 633699003876 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 633699003877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003878 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 633699003879 Walker A motif; other site 633699003880 ATP binding site [chemical binding]; other site 633699003881 Walker B motif; other site 633699003882 arginine finger; other site 633699003883 Uncharacterized conserved protein [Function unknown]; Region: COG3410 633699003884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699003885 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633699003886 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 633699003887 active site 633699003888 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 633699003889 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633699003890 synthetase active site [active] 633699003891 NTP binding site [chemical binding]; other site 633699003892 metal binding site [ion binding]; metal-binding site 633699003893 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 633699003894 putative active site [active] 633699003895 putative metal binding residues [ion binding]; other site 633699003896 signature motif; other site 633699003897 putative triphosphate binding site [ion binding]; other site 633699003898 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633699003899 Thioredoxin; Region: Thioredoxin_5; pfam13743 633699003900 Competence protein CoiA-like family; Region: CoiA; cl11541 633699003901 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 633699003902 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 633699003903 ArsC family; Region: ArsC; pfam03960 633699003904 putative catalytic residues [active] 633699003905 thiol/disulfide switch; other site 633699003906 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 633699003907 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 633699003908 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 633699003909 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 633699003910 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 633699003911 dimerization domain swap beta strand [polypeptide binding]; other site 633699003912 regulatory protein interface [polypeptide binding]; other site 633699003913 active site 633699003914 regulatory phosphorylation site [posttranslational modification]; other site 633699003915 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 633699003916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003917 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633699003918 Walker A motif; other site 633699003919 ATP binding site [chemical binding]; other site 633699003920 Walker B motif; other site 633699003921 arginine finger; other site 633699003922 UvrB/uvrC motif; Region: UVR; pfam02151 633699003923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699003924 Walker A motif; other site 633699003925 ATP binding site [chemical binding]; other site 633699003926 Walker B motif; other site 633699003927 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 633699003928 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 633699003929 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 633699003930 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 633699003931 G1 box; other site 633699003932 putative GEF interaction site [polypeptide binding]; other site 633699003933 GTP/Mg2+ binding site [chemical binding]; other site 633699003934 Switch I region; other site 633699003935 G2 box; other site 633699003936 G3 box; other site 633699003937 Switch II region; other site 633699003938 G4 box; other site 633699003939 G5 box; other site 633699003940 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 633699003941 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 633699003942 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633699003943 Transporter associated domain; Region: CorC_HlyC; cl08393 633699003944 Protein of unknown function (DUF402); Region: DUF402; cl00979 633699003945 RecX family; Region: RecX; cl00936 633699003946 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 633699003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 633699003948 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 633699003949 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 633699003950 dimer interface [polypeptide binding]; other site 633699003951 active site 633699003952 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 633699003953 homodimer interface [polypeptide binding]; other site 633699003954 catalytic residues [active] 633699003955 NAD binding site [chemical binding]; other site 633699003956 substrate binding pocket [chemical binding]; other site 633699003957 flexible flap; other site 633699003958 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 633699003959 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 633699003960 dimer interface [polypeptide binding]; other site 633699003961 active site 633699003962 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 633699003963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699003964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699003965 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699003966 active site 633699003967 motif I; other site 633699003968 motif II; other site 633699003969 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699003970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699003971 putative substrate translocation pore; other site 633699003972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699003973 glutamine synthetase, type I; Region: GlnA; TIGR00653 633699003974 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 633699003975 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633699003976 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 633699003977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699003978 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 633699003979 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633699003980 active site residue [active] 633699003981 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 633699003982 Rhomboid family; Region: Rhomboid; cl11446 633699003983 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 633699003984 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 633699003985 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 633699003986 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633699003987 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 633699003988 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633699003989 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699003990 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 633699003991 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633699003992 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633699003993 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633699003994 YceG-like family; Region: YceG; pfam02618 633699003995 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 633699003996 dimerization interface [polypeptide binding]; other site 633699003997 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 633699003998 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633699003999 putative tRNA-binding site [nucleotide binding]; other site 633699004000 B3/4 domain; Region: B3_4; cl11458 633699004001 tRNA synthetase B5 domain; Region: B5; cl08394 633699004002 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 633699004003 dimer interface [polypeptide binding]; other site 633699004004 motif 1; other site 633699004005 motif 3; other site 633699004006 motif 2; other site 633699004007 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 633699004008 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 633699004009 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 633699004010 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 633699004011 dimer interface [polypeptide binding]; other site 633699004012 motif 1; other site 633699004013 active site 633699004014 motif 2; other site 633699004015 motif 3; other site 633699004016 Helix-turn-helix domains; Region: HTH; cl00088 633699004017 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 633699004018 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 633699004019 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 633699004020 Acylphosphatase; Region: Acylphosphatase; cl00551 633699004021 OxaA-like protein precursor; Provisional; Region: PRK02463 633699004022 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 633699004023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633699004024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 633699004025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699004026 dimer interface [polypeptide binding]; other site 633699004027 phosphorylation site [posttranslational modification] 633699004028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699004029 ATP binding site [chemical binding]; other site 633699004030 Mg2+ binding site [ion binding]; other site 633699004031 G-X-G motif; other site 633699004032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699004033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699004034 active site 633699004035 phosphorylation site [posttranslational modification] 633699004036 intermolecular recognition site; other site 633699004037 dimerization interface [polypeptide binding]; other site 633699004038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699004039 DNA binding site [nucleotide binding] 633699004040 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 633699004041 hypothetical protein; Provisional; Region: PRK13670 633699004042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699004043 Oligomerisation domain; Region: Oligomerisation; cl00519 633699004044 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 633699004045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633699004046 Zn2+ binding site [ion binding]; other site 633699004047 Mg2+ binding site [ion binding]; other site 633699004048 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 633699004049 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 633699004050 active site 633699004051 (T/H)XGH motif; other site 633699004052 GTPase YqeH; Provisional; Region: PRK13796 633699004053 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 633699004054 GTP/Mg2+ binding site [chemical binding]; other site 633699004055 G4 box; other site 633699004056 G5 box; other site 633699004057 G1 box; other site 633699004058 Switch I region; other site 633699004059 G2 box; other site 633699004060 G3 box; other site 633699004061 Switch II region; other site 633699004062 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 633699004063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004064 active site 633699004065 motif I; other site 633699004066 motif II; other site 633699004067 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633699004068 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 633699004069 23S rRNA binding site [nucleotide binding]; other site 633699004070 L21 binding site [polypeptide binding]; other site 633699004071 L13 binding site [polypeptide binding]; other site 633699004072 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 633699004073 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 633699004074 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 633699004075 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 633699004076 CAAX protease self-immunity; Region: Abi; cl00558 633699004077 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 633699004078 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 633699004079 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 633699004080 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 633699004081 active site 633699004082 dimer interface [polypeptide binding]; other site 633699004083 motif 1; other site 633699004084 motif 2; other site 633699004085 motif 3; other site 633699004086 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 633699004087 anticodon binding site; other site 633699004088 primosomal protein DnaI; Reviewed; Region: PRK08939 633699004089 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 633699004090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004091 Walker A motif; other site 633699004092 ATP binding site [chemical binding]; other site 633699004093 Walker B motif; other site 633699004094 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 633699004095 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 633699004096 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 633699004097 ATP cone domain; Region: ATP-cone; pfam03477 633699004098 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 633699004099 dephospho-CoA kinase; Region: TIGR00152 633699004100 CoA-binding site [chemical binding]; other site 633699004101 ATP-binding [chemical binding]; other site 633699004102 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 633699004103 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 633699004104 DNA binding site [nucleotide binding] 633699004105 catalytic residue [active] 633699004106 H2TH interface [polypeptide binding]; other site 633699004107 putative catalytic residues [active] 633699004108 turnover-facilitating residue; other site 633699004109 intercalation triad [nucleotide binding]; other site 633699004110 8OG recognition residue [nucleotide binding]; other site 633699004111 putative reading head residues; other site 633699004112 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 633699004113 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 633699004114 DNA polymerase I; Provisional; Region: PRK05755 633699004115 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 633699004116 active site 633699004117 metal binding site 1 [ion binding]; metal-binding site 633699004118 putative 5' ssDNA interaction site; other site 633699004119 metal binding site 3; metal-binding site 633699004120 metal binding site 2 [ion binding]; metal-binding site 633699004121 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 633699004122 putative DNA binding site [nucleotide binding]; other site 633699004123 putative metal binding site [ion binding]; other site 633699004124 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 633699004125 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 633699004126 active site 633699004127 DNA binding site [nucleotide binding] 633699004128 catalytic site [active] 633699004129 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 633699004130 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 633699004131 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 633699004132 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699004133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699004134 DNA-binding site [nucleotide binding]; DNA binding site 633699004135 UTRA domain; Region: UTRA; cl01230 633699004136 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 633699004137 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699004138 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699004139 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699004140 CutC family; Region: CutC; cl01218 633699004141 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633699004142 putative tRNA-binding site [nucleotide binding]; other site 633699004143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633699004144 catalytic residues [active] 633699004145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004146 S-adenosylmethionine binding site [chemical binding]; other site 633699004147 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 633699004148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004149 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 633699004150 Walker A/P-loop; other site 633699004151 ATP binding site [chemical binding]; other site 633699004152 Q-loop/lid; other site 633699004153 ABC transporter signature motif; other site 633699004154 Walker B; other site 633699004155 D-loop; other site 633699004156 H-loop/switch region; other site 633699004157 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 633699004158 HIT family signature motif; other site 633699004159 catalytic residue [active] 633699004160 YtxH-like protein; Region: YtxH; cl02079 633699004161 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 633699004162 PPIC-type PPIASE domain; Region: Rotamase; cl08278 633699004163 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 633699004164 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 633699004165 generic binding surface II; other site 633699004166 generic binding surface I; other site 633699004167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 633699004168 Uncharacterized conserved protein [Function unknown]; Region: COG4717 633699004169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004170 Uncharacterized conserved protein [Function unknown]; Region: COG4717 633699004171 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 633699004172 active site 633699004173 metal binding site [ion binding]; metal-binding site 633699004174 DNA binding site [nucleotide binding] 633699004175 Protein of unknown function (DUF964); Region: DUF964; cl01483 633699004176 Transglycosylase; Region: Transgly; cl07896 633699004177 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633699004178 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004179 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633699004180 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 633699004181 active site 633699004182 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 633699004183 active site 633699004184 ATP binding site [chemical binding]; other site 633699004185 Phosphotransferase enzyme family; Region: APH; pfam01636 633699004186 antibiotic binding site [chemical binding]; other site 633699004187 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004188 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 633699004189 ligand binding site [chemical binding]; other site 633699004190 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 633699004191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 633699004192 ligand binding site [chemical binding]; other site 633699004193 flexible hinge region; other site 633699004194 Helix-turn-helix domains; Region: HTH; cl00088 633699004195 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633699004196 metal-binding site [ion binding] 633699004197 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 633699004198 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004199 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699004200 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 633699004201 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 633699004202 Gram positive anchor; Region: Gram_pos_anchor; cl15427 633699004203 MucBP domain; Region: MucBP; pfam06458 633699004204 MucBP domain; Region: MucBP; pfam06458 633699004205 MucBP domain; Region: MucBP; pfam06458 633699004206 MucBP domain; Region: MucBP; pfam06458 633699004207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 633699004208 Transposase domain (DUF772); Region: DUF772; cl15789 633699004209 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 633699004210 Helix-turn-helix domains; Region: HTH; cl00088 633699004211 Integrase core domain; Region: rve; cl01316 633699004212 Recombinase; Region: Recombinase; pfam07508 633699004213 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633699004214 Isochorismatase family; Region: Isochorismatase; pfam00857 633699004215 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 633699004216 catalytic triad [active] 633699004217 conserved cis-peptide bond; other site 633699004218 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 633699004219 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 633699004220 active site 633699004221 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 633699004222 nudix motif; other site 633699004223 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 633699004224 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 633699004225 TRAM domain; Region: TRAM; cl01282 633699004226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633699004227 S-adenosylmethionine binding site [chemical binding]; other site 633699004228 ABC-2 type transporter; Region: ABC2_membrane; cl11417 633699004229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004230 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 633699004231 Walker A/P-loop; other site 633699004232 ATP binding site [chemical binding]; other site 633699004233 Q-loop/lid; other site 633699004234 ABC transporter signature motif; other site 633699004235 Walker B; other site 633699004236 D-loop; other site 633699004237 H-loop/switch region; other site 633699004238 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 633699004239 Uncharacterized conserved protein [Function unknown]; Region: COG1912 633699004240 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 633699004241 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 633699004242 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004243 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699004244 Walker A/P-loop; other site 633699004245 ATP binding site [chemical binding]; other site 633699004246 Q-loop/lid; other site 633699004247 ABC transporter signature motif; other site 633699004248 Walker B; other site 633699004249 D-loop; other site 633699004250 H-loop/switch region; other site 633699004251 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 633699004252 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004253 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 633699004254 Walker A/P-loop; other site 633699004255 ATP binding site [chemical binding]; other site 633699004256 Q-loop/lid; other site 633699004257 ABC transporter signature motif; other site 633699004258 Walker B; other site 633699004259 D-loop; other site 633699004260 H-loop/switch region; other site 633699004261 Cobalt transport protein; Region: CbiQ; cl00463 633699004262 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 633699004263 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 633699004264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004265 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004266 active site 633699004267 motif I; other site 633699004268 motif II; other site 633699004269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004270 putative lipid kinase; Reviewed; Region: PRK13055 633699004271 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 633699004272 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 633699004273 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 633699004274 GatB domain; Region: GatB_Yqey; cl11497 633699004275 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 633699004276 Amidase; Region: Amidase; cl11426 633699004277 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 633699004278 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 633699004279 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 633699004280 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 633699004281 nucleotide binding pocket [chemical binding]; other site 633699004282 K-X-D-G motif; other site 633699004283 catalytic site [active] 633699004284 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 633699004285 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 633699004286 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 633699004287 Dimer interface [polypeptide binding]; other site 633699004288 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 633699004289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004290 Family description; Region: UvrD_C_2; cl15862 633699004291 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 633699004292 Predicted membrane protein [Function unknown]; Region: COG4684 633699004293 hypothetical protein; Provisional; Region: PRK04351 633699004294 SprT homologues; Region: SprT; cl01182 633699004295 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 633699004296 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 633699004297 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 633699004298 MatE; Region: MatE; cl10513 633699004299 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 633699004300 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699004301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699004302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004303 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699004304 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699004305 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699004306 stage V sporulation protein K; Region: spore_V_K; TIGR02881 633699004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004308 Walker A motif; other site 633699004309 ATP binding site [chemical binding]; other site 633699004310 Walker B motif; other site 633699004311 arginine finger; other site 633699004312 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 633699004313 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 633699004314 Ligand Binding Site [chemical binding]; other site 633699004315 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 633699004316 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 633699004317 active site 633699004318 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 633699004319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633699004320 active site 633699004321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699004322 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 633699004323 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 633699004324 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633699004325 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 633699004326 active site 633699004327 nucleotide binding site [chemical binding]; other site 633699004328 HIGH motif; other site 633699004329 KMSKS motif; other site 633699004330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633699004331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633699004332 DNA-binding site [nucleotide binding]; DNA binding site 633699004333 UTRA domain; Region: UTRA; cl01230 633699004334 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 633699004335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633699004336 active site residue [active] 633699004337 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633699004338 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699004339 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 633699004340 NAD binding site [chemical binding]; other site 633699004341 dimer interface [polypeptide binding]; other site 633699004342 substrate binding site [chemical binding]; other site 633699004343 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004344 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004345 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004346 putative active site [active] 633699004347 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 633699004348 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699004349 active site 633699004350 dimer interface [polypeptide binding]; other site 633699004351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633699004352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699004353 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 633699004354 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633699004355 Predicted membrane protein [Function unknown]; Region: COG4905 633699004356 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633699004357 Phosphate-starvation-inducible E; Region: PsiE; cl01264 633699004358 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699004359 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699004360 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699004361 active site 633699004362 catalytic tetrad [active] 633699004363 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 633699004364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633699004365 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 633699004366 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 633699004367 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 633699004368 NAD binding site [chemical binding]; other site 633699004369 homodimer interface [polypeptide binding]; other site 633699004370 active site 633699004371 substrate binding site [chemical binding]; other site 633699004372 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 633699004373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633699004374 ATP binding site [chemical binding]; other site 633699004375 putative Mg++ binding site [ion binding]; other site 633699004376 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633699004377 nucleotide binding region [chemical binding]; other site 633699004378 ATP-binding site [chemical binding]; other site 633699004379 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 633699004380 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 633699004381 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 633699004382 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 633699004383 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 633699004384 putative catalytic cysteine [active] 633699004385 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 633699004386 putative active site [active] 633699004387 metal binding site [ion binding]; metal-binding site 633699004388 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 633699004389 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 633699004390 Sulfatase; Region: Sulfatase; cl10460 633699004391 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 633699004392 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633699004393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633699004394 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 633699004395 putative ADP-binding pocket [chemical binding]; other site 633699004396 seryl-tRNA synthetase; Provisional; Region: PRK05431 633699004397 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 633699004398 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 633699004399 dimer interface [polypeptide binding]; other site 633699004400 active site 633699004401 motif 1; other site 633699004402 motif 2; other site 633699004403 motif 3; other site 633699004404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633699004405 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699004406 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633699004407 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 633699004408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699004409 salt bridge; other site 633699004410 non-specific DNA binding site [nucleotide binding]; other site 633699004411 sequence-specific DNA binding site [nucleotide binding]; other site 633699004412 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 633699004413 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 633699004414 NAD(P) binding site [chemical binding]; other site 633699004415 catalytic residues [active] 633699004416 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 633699004417 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633699004418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004419 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004420 active site 633699004421 motif I; other site 633699004422 motif II; other site 633699004423 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699004424 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 633699004425 Predicted membrane protein [Function unknown]; Region: COG1511 633699004426 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 633699004427 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 633699004428 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 633699004429 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 633699004430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699004431 Helix-turn-helix domains; Region: HTH; cl00088 633699004432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004433 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633699004434 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 633699004435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699004436 Coenzyme A binding pocket [chemical binding]; other site 633699004437 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699004438 Helix-turn-helix domains; Region: HTH; cl00088 633699004439 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 633699004440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 633699004441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633699004442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633699004443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 633699004444 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633699004445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 633699004446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699004447 dimer interface [polypeptide binding]; other site 633699004448 conserved gate region; other site 633699004449 putative PBP binding loops; other site 633699004450 ABC-ATPase subunit interface; other site 633699004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633699004452 dimer interface [polypeptide binding]; other site 633699004453 conserved gate region; other site 633699004454 putative PBP binding loops; other site 633699004455 ABC-ATPase subunit interface; other site 633699004456 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 633699004457 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 633699004458 Walker A/P-loop; other site 633699004459 ATP binding site [chemical binding]; other site 633699004460 Q-loop/lid; other site 633699004461 ABC transporter signature motif; other site 633699004462 Walker B; other site 633699004463 D-loop; other site 633699004464 H-loop/switch region; other site 633699004465 TOBE domain; Region: TOBE_2; cl01440 633699004466 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 633699004467 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699004468 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 633699004469 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 633699004470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699004471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699004472 active site 633699004473 catalytic tetrad [active] 633699004474 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699004475 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 633699004476 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 633699004477 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633699004478 active site 633699004479 catalytic site [active] 633699004480 substrate binding site [chemical binding]; other site 633699004481 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 633699004482 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 633699004483 Protein of unknown function (DUF421); Region: DUF421; cl00990 633699004484 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 633699004485 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633699004486 peptidase T; Region: peptidase-T; TIGR01882 633699004487 metal binding site [ion binding]; metal-binding site 633699004488 dimer interface [polypeptide binding]; other site 633699004489 PAS domain; Region: PAS_10; pfam13596 633699004490 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 633699004491 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 633699004492 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 633699004493 PAS domain; Region: PAS_10; pfam13596 633699004494 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 633699004495 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 633699004496 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 633699004497 substrate binding site [chemical binding]; other site 633699004498 THF binding site; other site 633699004499 zinc-binding site [ion binding]; other site 633699004500 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 633699004501 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 633699004502 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 633699004503 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 633699004504 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699004505 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633699004506 active pocket/dimerization site; other site 633699004507 active site 633699004508 phosphorylation site [posttranslational modification] 633699004509 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 633699004510 active site 633699004511 phosphorylation site [posttranslational modification] 633699004512 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 633699004513 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633699004514 peptide binding site [polypeptide binding]; other site 633699004515 EamA-like transporter family; Region: EamA; cl01037 633699004516 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 633699004517 EamA-like transporter family; Region: EamA; cl01037 633699004518 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004519 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004520 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 633699004521 HPr interaction site; other site 633699004522 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699004523 active site 633699004524 phosphorylation site [posttranslational modification] 633699004525 CAT RNA binding domain; Region: CAT_RBD; cl03904 633699004526 PRD domain; Region: PRD; cl15445 633699004527 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 633699004528 elongation factor P; Validated; Region: PRK00529 633699004529 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633699004530 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633699004531 RNA binding site [nucleotide binding]; other site 633699004532 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633699004533 RNA binding site [nucleotide binding]; other site 633699004534 pantothenate kinase; Provisional; Region: PRK05439 633699004535 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 633699004536 ATP-binding site [chemical binding]; other site 633699004537 CoA-binding site [chemical binding]; other site 633699004538 Mg2+-binding site [ion binding]; other site 633699004539 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 633699004540 active site 633699004541 catalytic triad [active] 633699004542 oxyanion hole [active] 633699004543 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 633699004544 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 633699004545 putative active site [active] 633699004546 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 633699004547 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004548 Family description; Region: UvrD_C_2; cl15862 633699004549 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 633699004550 active site 633699004551 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 633699004552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633699004553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004554 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633699004555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004556 motif II; other site 633699004557 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633699004558 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004559 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004560 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004561 putative active site [active] 633699004562 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 633699004563 putative active site cavity [active] 633699004564 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 633699004565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004566 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004567 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004568 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699004569 active site turn [active] 633699004570 phosphorylation site [posttranslational modification] 633699004571 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 633699004572 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699004573 HPr interaction site; other site 633699004574 active site 633699004575 phosphorylation site [posttranslational modification] 633699004576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004577 catalytic core [active] 633699004578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004579 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 633699004580 Walker A/P-loop; other site 633699004581 ATP binding site [chemical binding]; other site 633699004582 Q-loop/lid; other site 633699004583 ABC transporter signature motif; other site 633699004584 Walker B; other site 633699004585 D-loop; other site 633699004586 H-loop/switch region; other site 633699004587 Amino acid permease; Region: AA_permease_2; pfam13520 633699004588 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 633699004589 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 633699004590 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 633699004591 HflX GTPase family; Region: HflX; cd01878 633699004592 G1 box; other site 633699004593 GTP/Mg2+ binding site [chemical binding]; other site 633699004594 Switch I region; other site 633699004595 G2 box; other site 633699004596 G3 box; other site 633699004597 Switch II region; other site 633699004598 G4 box; other site 633699004599 G5 box; other site 633699004600 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 633699004601 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 633699004602 NlpC/P60 family; Region: NLPC_P60; cl11438 633699004603 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 633699004604 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633699004605 catalytic site [active] 633699004606 G-X2-G-X-G-K; other site 633699004607 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 633699004608 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 633699004609 dimer interface [polypeptide binding]; other site 633699004610 putative radical transfer pathway; other site 633699004611 diiron center [ion binding]; other site 633699004612 tyrosyl radical; other site 633699004613 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 633699004614 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 633699004615 Uncharacterized conserved protein [Function unknown]; Region: COG2966 633699004616 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 633699004617 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633699004618 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699004619 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699004620 ABC transporter; Region: ABC_tran_2; pfam12848 633699004621 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 633699004622 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 633699004623 oligoendopeptidase F; Region: pepF; TIGR00181 633699004624 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 633699004625 active site 633699004626 Zn binding site [ion binding]; other site 633699004627 L-lactate permease; Region: Lactate_perm; cl00701 633699004628 glycolate transporter; Provisional; Region: PRK09695 633699004629 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633699004630 ABC-ATPase subunit interface; other site 633699004631 dimer interface [polypeptide binding]; other site 633699004632 putative PBP binding regions; other site 633699004633 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633699004634 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 633699004635 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 633699004636 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 633699004637 metal binding site [ion binding]; metal-binding site 633699004638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633699004639 dimerization interface [polypeptide binding]; other site 633699004640 putative DNA binding site [nucleotide binding]; other site 633699004641 putative Zn2+ binding site [ion binding]; other site 633699004642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004643 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633699004644 active site 633699004645 motif I; other site 633699004646 motif II; other site 633699004647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633699004648 MucBP domain; Region: MucBP; pfam06458 633699004649 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 633699004650 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633699004651 active site 633699004652 phosphorylation site [posttranslational modification] 633699004653 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 633699004654 active site 633699004655 P-loop; other site 633699004656 phosphorylation site [posttranslational modification] 633699004657 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004658 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633699004659 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633699004660 putative substrate binding site [chemical binding]; other site 633699004661 putative ATP binding site [chemical binding]; other site 633699004662 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633699004663 Helix-turn-helix domains; Region: HTH; cl00088 633699004664 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 633699004665 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 633699004666 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 633699004667 trimer interface [polypeptide binding]; other site 633699004668 active site 633699004669 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 633699004670 catalytic site [active] 633699004671 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 633699004672 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 633699004673 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004674 Walker A/P-loop; other site 633699004675 ATP binding site [chemical binding]; other site 633699004676 Q-loop/lid; other site 633699004677 ABC transporter signature motif; other site 633699004678 Walker B; other site 633699004679 D-loop; other site 633699004680 H-loop/switch region; other site 633699004681 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 633699004682 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 633699004683 aspartate racemase; Region: asp_race; TIGR00035 633699004684 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 633699004685 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633699004686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633699004687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633699004688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 633699004689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633699004690 dimer interface [polypeptide binding]; other site 633699004691 phosphorylation site [posttranslational modification] 633699004692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633699004693 ATP binding site [chemical binding]; other site 633699004694 Mg2+ binding site [ion binding]; other site 633699004695 G-X-G motif; other site 633699004696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633699004697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633699004698 active site 633699004699 phosphorylation site [posttranslational modification] 633699004700 intermolecular recognition site; other site 633699004701 dimerization interface [polypeptide binding]; other site 633699004702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633699004703 DNA binding site [nucleotide binding] 633699004704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004705 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004706 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 633699004707 Walker A/P-loop; other site 633699004708 ATP binding site [chemical binding]; other site 633699004709 Q-loop/lid; other site 633699004710 ABC transporter signature motif; other site 633699004711 Walker B; other site 633699004712 D-loop; other site 633699004713 H-loop/switch region; other site 633699004714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004715 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004717 Walker A/P-loop; other site 633699004718 ATP binding site [chemical binding]; other site 633699004719 Q-loop/lid; other site 633699004720 ABC transporter signature motif; other site 633699004721 Walker B; other site 633699004722 D-loop; other site 633699004723 H-loop/switch region; other site 633699004724 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 633699004725 GTP-binding protein YchF; Reviewed; Region: PRK09601 633699004726 YchF GTPase; Region: YchF; cd01900 633699004727 G1 box; other site 633699004728 GTP/Mg2+ binding site [chemical binding]; other site 633699004729 Switch I region; other site 633699004730 G2 box; other site 633699004731 Switch II region; other site 633699004732 G3 box; other site 633699004733 G4 box; other site 633699004734 G5 box; other site 633699004735 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 633699004736 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 633699004737 ParB-like partition proteins; Region: parB_part; TIGR00180 633699004738 ParB-like nuclease domain; Region: ParBc; cl02129 633699004739 KorB domain; Region: KorB; pfam08535 633699004740 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 633699004741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004742 ParB-like partition proteins; Region: parB_part; TIGR00180 633699004743 ParB-like nuclease domain; Region: ParBc; cl02129 633699004744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 633699004745 Colicin V production protein; Region: Colicin_V; cl00567 633699004746 ApbE family; Region: ApbE; cl00643 633699004747 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 633699004748 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 633699004749 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699004750 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 633699004751 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 633699004752 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 633699004753 Helix-turn-helix domains; Region: HTH; cl00088 633699004754 WHG domain; Region: WHG; pfam13305 633699004755 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 633699004756 Peptidase family C69; Region: Peptidase_C69; pfam03577 633699004757 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004758 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633699004759 CAT RNA binding domain; Region: CAT_RBD; cl03904 633699004760 CAT RNA binding domain; Region: CAT_RBD; cl03904 633699004761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004762 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 633699004763 Walker A/P-loop; other site 633699004764 ATP binding site [chemical binding]; other site 633699004765 Q-loop/lid; other site 633699004766 ABC transporter signature motif; other site 633699004767 Walker B; other site 633699004768 D-loop; other site 633699004769 H-loop/switch region; other site 633699004770 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 633699004771 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 633699004772 FtsX-like permease family; Region: FtsX; cl15850 633699004773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633699004774 Helix-turn-helix domains; Region: HTH; cl00088 633699004775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004776 catalytic core [active] 633699004777 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633699004778 catalytic core [active] 633699004779 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 633699004780 nucleophilic elbow; other site 633699004781 catalytic triad; other site 633699004782 Protein of unknown function (DUF328); Region: DUF328; cl01143 633699004783 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 633699004784 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 633699004785 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 633699004786 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 633699004787 putative active site [active] 633699004788 catalytic site [active] 633699004789 putative metal binding site [ion binding]; other site 633699004790 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004791 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633699004792 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633699004793 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633699004794 putative active site [active] 633699004795 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 633699004796 nucleotide binding site/active site [active] 633699004797 HIT family signature motif; other site 633699004798 catalytic residue [active] 633699004799 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 633699004800 drug efflux system protein MdtG; Provisional; Region: PRK09874 633699004801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699004802 putative substrate translocation pore; other site 633699004803 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 633699004804 catalytic triad [active] 633699004805 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004806 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004807 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 633699004808 Walker A/P-loop; other site 633699004809 ATP binding site [chemical binding]; other site 633699004810 Q-loop/lid; other site 633699004811 ABC transporter signature motif; other site 633699004812 Walker B; other site 633699004813 D-loop; other site 633699004814 H-loop/switch region; other site 633699004815 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 633699004816 putative ADP-ribose binding site [chemical binding]; other site 633699004817 putative active site [active] 633699004818 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 633699004819 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633699004820 active site turn [active] 633699004821 phosphorylation site [posttranslational modification] 633699004822 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004823 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 633699004824 HPr interaction site; other site 633699004825 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633699004826 active site 633699004827 phosphorylation site [posttranslational modification] 633699004828 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633699004829 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633699004830 substrate binding [chemical binding]; other site 633699004831 active site 633699004832 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 633699004833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633699004834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633699004835 DNA binding site [nucleotide binding] 633699004836 domain linker motif; other site 633699004837 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 633699004838 dimerization interface [polypeptide binding]; other site 633699004839 ligand binding site [chemical binding]; other site 633699004840 sodium binding site [ion binding]; other site 633699004841 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 633699004842 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 633699004843 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 633699004844 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 633699004845 substrate binding site [chemical binding]; other site 633699004846 dimer interface [polypeptide binding]; other site 633699004847 ATP binding site [chemical binding]; other site 633699004848 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 633699004849 catalytic triad [active] 633699004850 amino acid transporter; Region: 2A0306; TIGR00909 633699004851 Spore germination protein; Region: Spore_permease; cl15802 633699004852 Spore germination protein; Region: Spore_permease; cl15802 633699004853 Spore germination protein; Region: Spore_permease; cl15802 633699004854 EamA-like transporter family; Region: EamA; cl01037 633699004855 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 633699004856 EamA-like transporter family; Region: EamA; cl01037 633699004857 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 633699004858 dimer interface [polypeptide binding]; other site 633699004859 active site 633699004860 Amino acid permease; Region: AA_permease; pfam00324 633699004861 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 633699004862 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 633699004863 catalytic triad [active] 633699004864 putative transport protein YifK; Provisional; Region: PRK10746 633699004865 putative transport protein YifK; Provisional; Region: PRK10746 633699004866 Domain of unknown function (DUF956); Region: DUF956; cl01917 633699004867 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 633699004868 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 633699004869 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633699004870 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633699004871 active pocket/dimerization site; other site 633699004872 active site 633699004873 phosphorylation site [posttranslational modification] 633699004874 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 633699004875 active site 633699004876 phosphorylation site [posttranslational modification] 633699004877 amino acid transporter; Region: 2A0306; TIGR00909 633699004878 Spore germination protein; Region: Spore_permease; cl15802 633699004879 Spore germination protein; Region: Spore_permease; cl15802 633699004880 Spore germination protein; Region: Spore_permease; cl15802 633699004881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004882 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633699004883 Walker A motif; other site 633699004884 ATP binding site [chemical binding]; other site 633699004885 Walker B motif; other site 633699004886 arginine finger; other site 633699004887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633699004888 Walker A motif; other site 633699004889 ATP binding site [chemical binding]; other site 633699004890 Walker B motif; other site 633699004891 arginine finger; other site 633699004892 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 633699004893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 633699004894 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699004896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633699004897 putative substrate translocation pore; other site 633699004898 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004899 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 633699004900 DltD N-terminal region; Region: DltD_N; pfam04915 633699004901 DltD central region; Region: DltD_M; pfam04918 633699004902 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 633699004903 Phosphopantetheine attachment site; Region: PP-binding; cl09936 633699004904 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 633699004905 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 633699004906 AMP-binding enzyme; Region: AMP-binding; cl15778 633699004907 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 633699004908 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 633699004909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699004910 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699004911 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 633699004912 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 633699004913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699004914 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004915 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004916 Walker A/P-loop; other site 633699004917 ATP binding site [chemical binding]; other site 633699004918 Q-loop/lid; other site 633699004919 ABC transporter signature motif; other site 633699004920 Walker B; other site 633699004921 D-loop; other site 633699004922 H-loop/switch region; other site 633699004923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699004924 non-specific DNA binding site [nucleotide binding]; other site 633699004925 salt bridge; other site 633699004926 sequence-specific DNA binding site [nucleotide binding]; other site 633699004927 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 633699004928 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 633699004929 putative substrate binding pocket [chemical binding]; other site 633699004930 AC domain interface; other site 633699004931 catalytic triad [active] 633699004932 AB domain interface; other site 633699004933 interchain disulfide; other site 633699004934 Protein of unknown function (DUF979); Region: DUF979; cl01572 633699004935 Protein of unknown function (DUF969); Region: DUF969; cl01573 633699004936 Protein of unknown function (DUF805); Region: DUF805; cl01224 633699004937 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633699004938 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633699004939 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 633699004940 CAAX protease self-immunity; Region: Abi; cl00558 633699004941 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 633699004942 putative active site [active] 633699004943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633699004944 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 633699004945 Walker A/P-loop; other site 633699004946 ATP binding site [chemical binding]; other site 633699004947 Q-loop/lid; other site 633699004948 ABC transporter signature motif; other site 633699004949 Walker B; other site 633699004950 D-loop; other site 633699004951 H-loop/switch region; other site 633699004952 FtsX-like permease family; Region: FtsX; cl15850 633699004953 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 633699004954 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 633699004955 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 633699004956 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 633699004957 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699004959 Walker A/P-loop; other site 633699004960 ATP binding site [chemical binding]; other site 633699004961 Q-loop/lid; other site 633699004962 ABC transporter signature motif; other site 633699004963 Walker B; other site 633699004964 D-loop; other site 633699004965 H-loop/switch region; other site 633699004966 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 633699004967 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699004968 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 633699004969 Walker A/P-loop; other site 633699004970 ATP binding site [chemical binding]; other site 633699004971 Q-loop/lid; other site 633699004972 ABC transporter signature motif; other site 633699004973 Walker B; other site 633699004974 D-loop; other site 633699004975 H-loop/switch region; other site 633699004976 UbiA prenyltransferase family; Region: UbiA; cl00337 633699004977 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 633699004978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633699004979 substrate binding pocket [chemical binding]; other site 633699004980 membrane-bound complex binding site; other site 633699004981 hinge residues; other site 633699004982 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 633699004983 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 633699004984 ligand binding site [chemical binding]; other site 633699004985 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633699004986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004987 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 633699004988 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 633699004989 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 633699004990 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 633699004991 Predicted esterase [General function prediction only]; Region: COG0627 633699004992 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 633699004993 active site 633699004994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 633699004995 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 633699004996 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 633699004997 putative active site [active] 633699004998 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 633699004999 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 633699005000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633699005001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 633699005002 active site 633699005003 catalytic tetrad [active] 633699005004 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 633699005005 active site 633699005006 trimer interface [polypeptide binding]; other site 633699005007 allosteric site; other site 633699005008 active site lid [active] 633699005009 hexamer (dimer of trimers) interface [polypeptide binding]; other site 633699005010 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 633699005011 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 633699005012 Substrate-binding site [chemical binding]; other site 633699005013 Substrate specificity [chemical binding]; other site 633699005014 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 633699005015 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 633699005016 Substrate-binding site [chemical binding]; other site 633699005017 Substrate specificity [chemical binding]; other site 633699005018 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 633699005019 teramer interface [polypeptide binding]; other site 633699005020 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 633699005021 active site 633699005022 FMN binding site [chemical binding]; other site 633699005023 catalytic residues [active] 633699005024 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005025 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 633699005026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633699005027 DNA binding residues [nucleotide binding] 633699005028 dimer interface [polypeptide binding]; other site 633699005029 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005030 Uncharacterized conserved protein [Function unknown]; Region: COG4997 633699005031 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633699005032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633699005033 non-specific DNA binding site [nucleotide binding]; other site 633699005034 salt bridge; other site 633699005035 sequence-specific DNA binding site [nucleotide binding]; other site 633699005036 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 633699005037 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633699005038 active site 633699005039 catalytic residues [active] 633699005040 metal binding site [ion binding]; metal-binding site 633699005041 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 633699005042 Helix-turn-helix domains; Region: HTH; cl00088 633699005043 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 633699005044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 633699005045 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 633699005046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633699005047 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 633699005048 Amino acid permease; Region: AA_permease_2; pfam13520 633699005049 ornithine decarboxylase; Provisional; Region: PRK13578 633699005050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633699005051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699005052 catalytic residue [active] 633699005053 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 633699005054 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 633699005055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633699005056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633699005057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 633699005058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633699005059 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 633699005060 Coenzyme A binding pocket [chemical binding]; other site 633699005061 cation transport protein; Region: 2A0119; TIGR00898 633699005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633699005063 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 633699005064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699005065 Walker A/P-loop; other site 633699005066 ATP binding site [chemical binding]; other site 633699005067 Q-loop/lid; other site 633699005068 ABC transporter signature motif; other site 633699005069 Walker B; other site 633699005070 D-loop; other site 633699005071 H-loop/switch region; other site 633699005072 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 633699005073 Cl- selectivity filter; other site 633699005074 Cl- binding residues [ion binding]; other site 633699005075 pore gating glutamate residue; other site 633699005076 dimer interface [polypeptide binding]; other site 633699005077 H+/Cl- coupling transport residue; other site 633699005078 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 633699005079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699005080 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 633699005081 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 633699005082 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 633699005083 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 633699005084 PYR/PP interface [polypeptide binding]; other site 633699005085 dimer interface [polypeptide binding]; other site 633699005086 tetramer interface [polypeptide binding]; other site 633699005087 TPP binding site [chemical binding]; other site 633699005088 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 633699005089 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 633699005090 TPP-binding site [chemical binding]; other site 633699005091 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 633699005092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699005093 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 633699005094 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 633699005095 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 633699005096 trmE is a tRNA modification GTPase; Region: trmE; cd04164 633699005097 G1 box; other site 633699005098 GTP/Mg2+ binding site [chemical binding]; other site 633699005099 Switch I region; other site 633699005100 G2 box; other site 633699005101 Switch II region; other site 633699005102 G3 box; other site 633699005103 G4 box; other site 633699005104 G5 box; other site 633699005105 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 633699005106 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 633699005107 Ribonuclease P; Region: Ribonuclease_P; cl00457 633699005108 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 633699005109 chain length determinant protein EpsF; Region: EpsF; TIGR03017 633699005110 Initiator Replication protein; Region: Rep_3; cl03080 633699005111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 633699005112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633699005113 active site 633699005114 DNA binding site [nucleotide binding] 633699005115 Int/Topo IB signature motif; other site 633699005116 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633699005117 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 633699005118 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633699005119 Domain of unknown function (DUF955); Region: DUF955; cl01076 633699005120 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 633699005121 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 633699005124 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633699005125 dimer interface [polypeptide binding]; other site 633699005126 ssDNA binding site [nucleotide binding]; other site 633699005127 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633699005128 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 633699005129 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633699005130 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 633699005131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 633699005132 Walker A/P-loop; other site 633699005133 ATP binding site [chemical binding]; other site 633699005134 Q-loop/lid; other site 633699005135 ABC transporter signature motif; other site 633699005136 Walker B; other site 633699005137 D-loop; other site 633699005138 H-loop/switch region; other site 633699005139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633699005140 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 633699005141 Walker A/P-loop; other site 633699005142 ATP binding site [chemical binding]; other site 633699005143 Q-loop/lid; other site 633699005144 ABC transporter signature motif; other site 633699005145 Walker B; other site 633699005146 D-loop; other site 633699005147 H-loop/switch region; other site 633699005148 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 633699005149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633699005150 ATP binding site [chemical binding]; other site