-- dump date 20120504_151146 -- class Genbank::misc_feature -- table misc_feature_note -- id note 889932000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 889932000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 889932000003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000004 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 889932000005 DNA polymerase III subunit beta; Validated; Region: PRK05643 889932000006 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 889932000007 putative DNA binding surface [nucleotide binding]; other site 889932000008 dimer interface [polypeptide binding]; other site 889932000009 beta-clamp/clamp loader binding surface; other site 889932000010 beta-clamp/translesion DNA polymerase binding surface; other site 889932000011 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889932000012 recombination protein F; Reviewed; Region: recF; PRK00064 889932000013 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 889932000014 Walker A/P-loop; other site 889932000015 ATP binding site [chemical binding]; other site 889932000016 Q-loop/lid; other site 889932000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000018 ABC transporter signature motif; other site 889932000019 Walker B; other site 889932000020 D-loop; other site 889932000021 H-loop/switch region; other site 889932000022 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 889932000023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932000024 Mg2+ binding site [ion binding]; other site 889932000025 G-X-G motif; other site 889932000026 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 889932000027 anchoring element; other site 889932000028 dimer interface [polypeptide binding]; other site 889932000029 ATP binding site [chemical binding]; other site 889932000030 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 889932000031 active site 889932000032 putative metal-binding site [ion binding]; other site 889932000033 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 889932000034 DNA gyrase subunit A; Validated; Region: PRK05560 889932000035 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 889932000036 CAP-like domain; other site 889932000037 active site 889932000038 primary dimer interface [polypeptide binding]; other site 889932000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932000045 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 889932000046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 889932000047 dimer interface [polypeptide binding]; other site 889932000048 ssDNA binding site [nucleotide binding]; other site 889932000049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932000050 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 889932000051 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 889932000052 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 889932000053 DHH family; Region: DHH; pfam01368 889932000054 DHHA1 domain; Region: DHHA1; pfam02272 889932000055 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 889932000056 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 889932000057 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 889932000058 replicative DNA helicase; Provisional; Region: PRK05748 889932000059 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 889932000060 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 889932000061 Walker A motif; other site 889932000062 ATP binding site [chemical binding]; other site 889932000063 Walker B motif; other site 889932000064 DNA binding loops [nucleotide binding] 889932000065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932000067 putative substrate translocation pore; other site 889932000068 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 889932000069 nucleotide binding site [chemical binding]; other site 889932000070 homotetrameric interface [polypeptide binding]; other site 889932000071 putative phosphate binding site [ion binding]; other site 889932000072 putative allosteric binding site; other site 889932000073 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 889932000074 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 889932000075 putative catalytic cysteine [active] 889932000076 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932000077 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932000078 peptide binding site [polypeptide binding]; other site 889932000079 glycogen branching enzyme; Provisional; Region: PRK12313 889932000080 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 889932000081 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 889932000082 active site 889932000083 catalytic site [active] 889932000084 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 889932000085 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 889932000086 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 889932000087 ligand binding site; other site 889932000088 oligomer interface; other site 889932000089 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 889932000090 dimer interface [polypeptide binding]; other site 889932000091 N-terminal domain interface [polypeptide binding]; other site 889932000092 sulfate 1 binding site; other site 889932000093 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 889932000094 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 889932000095 ligand binding site; other site 889932000096 oligomer interface; other site 889932000097 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 889932000098 dimer interface [polypeptide binding]; other site 889932000099 N-terminal domain interface [polypeptide binding]; other site 889932000100 sulfate 1 binding site; other site 889932000101 glycogen synthase; Provisional; Region: glgA; PRK00654 889932000102 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 889932000103 ADP-binding pocket [chemical binding]; other site 889932000104 homodimer interface [polypeptide binding]; other site 889932000105 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 889932000106 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 889932000107 active site pocket [active] 889932000108 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 889932000109 active site 889932000110 homodimer interface [polypeptide binding]; other site 889932000111 catalytic site [active] 889932000112 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 889932000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932000114 active site 889932000115 motif I; other site 889932000116 motif II; other site 889932000117 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932000118 beta-phosphoglucomutase; Region: bPGM; TIGR01990 889932000119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932000120 motif II; other site 889932000121 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 889932000122 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 889932000123 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 889932000124 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 889932000125 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 889932000126 DNA-binding site [nucleotide binding]; DNA binding site 889932000127 RNA-binding motif; other site 889932000128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932000129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932000130 active site 889932000131 phosphorylation site [posttranslational modification] 889932000132 intermolecular recognition site; other site 889932000133 dimerization interface [polypeptide binding]; other site 889932000134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932000135 DNA binding site [nucleotide binding] 889932000136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 889932000137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889932000138 dimerization interface [polypeptide binding]; other site 889932000139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 889932000140 putative active site [active] 889932000141 heme pocket [chemical binding]; other site 889932000142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932000143 dimer interface [polypeptide binding]; other site 889932000144 phosphorylation site [posttranslational modification] 889932000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932000146 ATP binding site [chemical binding]; other site 889932000147 Mg2+ binding site [ion binding]; other site 889932000148 G-X-G motif; other site 889932000149 YycH protein; Region: YycH; pfam07435 889932000150 YycH protein; Region: YycI; cl02015 889932000151 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932000152 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 889932000153 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889932000154 protein binding site [polypeptide binding]; other site 889932000155 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 889932000156 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 889932000157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932000158 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 889932000159 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932000160 Helix-turn-helix domains; Region: HTH; cl00088 889932000161 Integrase core domain; Region: rve; cl01316 889932000162 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 889932000163 NAD(P) binding site [chemical binding]; other site 889932000164 catalytic residues [active] 889932000165 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 889932000166 putative uracil binding site [chemical binding]; other site 889932000167 putative active site [active] 889932000168 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 889932000169 putative FMN binding site [chemical binding]; other site 889932000170 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 889932000171 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 889932000172 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932000173 FAD binding domain; Region: FAD_binding_2; pfam00890 889932000174 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06069 889932000175 FMN-binding domain; Region: FMN_bind; cl01081 889932000176 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889932000177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932000178 transmembrane helices; other site 889932000179 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932000180 Low molecular weight phosphatase family; Region: LMWPc; cd00115 889932000181 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 889932000182 active site 889932000183 hypothetical protein; Provisional; Region: PRK06194 889932000184 classical (c) SDRs; Region: SDR_c; cd05233 889932000185 NAD(P) binding site [chemical binding]; other site 889932000186 active site 889932000187 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 889932000188 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 889932000189 dimer interface [polypeptide binding]; other site 889932000190 FMN binding site [chemical binding]; other site 889932000191 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 889932000192 Helix-turn-helix domains; Region: HTH; cl00088 889932000193 beta-phosphoglucomutase; Region: bPGM; TIGR01990 889932000194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932000195 motif II; other site 889932000196 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 889932000197 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 889932000198 active site 889932000199 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889932000200 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932000201 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932000202 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 889932000203 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 889932000204 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 889932000205 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 889932000206 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 889932000207 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 889932000208 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 889932000209 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 889932000210 catalytic triad [active] 889932000211 Predicted transcriptional regulator [Transcription]; Region: COG2378 889932000212 Helix-turn-helix domains; Region: HTH; cl00088 889932000213 WYL domain; Region: WYL; cl14852 889932000214 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932000215 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 889932000216 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 889932000217 G1 box; other site 889932000218 putative GEF interaction site [polypeptide binding]; other site 889932000219 GTP/Mg2+ binding site [chemical binding]; other site 889932000220 Switch I region; other site 889932000221 G2 box; other site 889932000222 G3 box; other site 889932000223 Switch II region; other site 889932000224 G4 box; other site 889932000225 G5 box; other site 889932000226 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 889932000227 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 889932000228 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 889932000229 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932000230 EamA-like transporter family; Region: EamA; cl01037 889932000231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 889932000232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932000233 Coenzyme A binding pocket [chemical binding]; other site 889932000234 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 889932000235 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 889932000236 potential catalytic triad [active] 889932000237 conserved cys residue [active] 889932000238 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932000239 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 889932000240 putative NAD(P) binding site [chemical binding]; other site 889932000241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932000242 dimerization interface [polypeptide binding]; other site 889932000243 putative DNA binding site [nucleotide binding]; other site 889932000244 putative Zn2+ binding site [ion binding]; other site 889932000245 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 889932000246 MatE; Region: MatE; cl10513 889932000247 MatE; Region: MatE; cl10513 889932000248 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 889932000249 Protein of unknown function (DUF328); Region: DUF328; cl01143 889932000250 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932000251 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932000252 peptide binding site [polypeptide binding]; other site 889932000253 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 889932000254 active site 889932000255 NTP binding site [chemical binding]; other site 889932000256 metal binding triad [ion binding]; metal-binding site 889932000257 antibiotic binding site [chemical binding]; other site 889932000258 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 889932000259 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889932000260 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932000261 Walker A/P-loop; other site 889932000262 ATP binding site [chemical binding]; other site 889932000263 Q-loop/lid; other site 889932000264 ABC transporter signature motif; other site 889932000265 Walker B; other site 889932000266 D-loop; other site 889932000267 H-loop/switch region; other site 889932000268 Cobalt transport protein; Region: CbiQ; cl00463 889932000269 cobalt transport protein CbiM; Provisional; Region: PRK07331 889932000270 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 889932000271 PDGLE domain; Region: PDGLE; cl07986 889932000272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 889932000273 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 889932000274 ligand binding site [chemical binding]; other site 889932000275 flexible hinge region; other site 889932000276 Helix-turn-helix domains; Region: HTH; cl00088 889932000277 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 889932000278 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 889932000279 AIR carboxylase; Region: AIRC; cl00310 889932000280 Protein of unknown function DUF111; Region: DUF111; cl03398 889932000281 Protein of unknown function DUF111; Region: DUF111; cl03398 889932000282 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889932000283 amphipathic channel; other site 889932000284 Asn-Pro-Ala signature motifs; other site 889932000285 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 889932000286 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 889932000287 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932000288 putative NAD(P) binding site [chemical binding]; other site 889932000289 substrate binding site [chemical binding]; other site 889932000290 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 889932000291 substrate binding site [chemical binding]; other site 889932000292 multimerization interface [polypeptide binding]; other site 889932000293 ATP binding site [chemical binding]; other site 889932000294 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 889932000295 dimer interface [polypeptide binding]; other site 889932000296 substrate binding site [chemical binding]; other site 889932000297 ATP binding site [chemical binding]; other site 889932000298 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 889932000299 thiamine phosphate binding site [chemical binding]; other site 889932000300 active site 889932000301 pyrophosphate binding site [ion binding]; other site 889932000302 Sodium:solute symporter family; Region: SSF; cl00456 889932000303 Peptidase C26; Region: Peptidase_C26; pfam07722 889932000304 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 889932000305 catalytic triad [active] 889932000306 HIRAN domain; Region: HIRAN; cl07418 889932000307 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 889932000308 nudix motif; other site 889932000309 putative transport protein YifK; Provisional; Region: PRK10746 889932000310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889932000311 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 889932000312 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 889932000313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932000314 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 889932000315 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932000316 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 889932000317 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 889932000318 PspC domain; Region: PspC; cl00864 889932000319 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932000320 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 889932000321 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 889932000322 putative dimer interface [polypeptide binding]; other site 889932000323 LytTr DNA-binding domain; Region: LytTR; cl04498 889932000324 drug efflux system protein MdtG; Provisional; Region: PRK09874 889932000325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000326 putative substrate translocation pore; other site 889932000327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932000328 dimerization interface [polypeptide binding]; other site 889932000329 putative DNA binding site [nucleotide binding]; other site 889932000330 putative Zn2+ binding site [ion binding]; other site 889932000331 cyanate transporter; Region: CynX; TIGR00896 889932000332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000333 putative substrate translocation pore; other site 889932000334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932000335 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932000336 active site 889932000337 catalytic tetrad [active] 889932000338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932000339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932000340 active site 889932000341 catalytic tetrad [active] 889932000342 TIR domain; Region: TIR_2; cl15770 889932000343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932000344 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 889932000345 putative active site [active] 889932000346 putative FMN binding site [chemical binding]; other site 889932000347 putative substrate binding site [chemical binding]; other site 889932000348 putative catalytic residue [active] 889932000349 Cobalt transport protein; Region: CbiQ; cl00463 889932000350 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 889932000351 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932000352 Walker A/P-loop; other site 889932000353 ATP binding site [chemical binding]; other site 889932000354 Q-loop/lid; other site 889932000355 ABC transporter signature motif; other site 889932000356 Walker B; other site 889932000357 D-loop; other site 889932000358 H-loop/switch region; other site 889932000359 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 889932000360 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932000361 Walker A/P-loop; other site 889932000362 ATP binding site [chemical binding]; other site 889932000363 Q-loop/lid; other site 889932000364 ABC transporter signature motif; other site 889932000365 Walker B; other site 889932000366 D-loop; other site 889932000367 H-loop/switch region; other site 889932000368 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889932000369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932000370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932000371 DNA-binding site [nucleotide binding]; DNA binding site 889932000372 UTRA domain; Region: UTRA; cl01230 889932000373 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 889932000374 classical (c) SDRs; Region: SDR_c; cd05233 889932000375 NAD(P) binding site [chemical binding]; other site 889932000376 active site 889932000377 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932000378 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932000379 Walker A/P-loop; other site 889932000380 ATP binding site [chemical binding]; other site 889932000381 Q-loop/lid; other site 889932000382 ABC transporter signature motif; other site 889932000383 Walker B; other site 889932000384 D-loop; other site 889932000385 H-loop/switch region; other site 889932000386 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 889932000387 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932000388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932000389 Helix-turn-helix domains; Region: HTH; cl00088 889932000390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 889932000391 active site 889932000392 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 889932000393 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 889932000394 Helix-turn-helix domains; Region: HTH; cl00088 889932000395 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 889932000396 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 889932000397 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 889932000398 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 889932000399 DAK2 domain; Region: Dak2; cl03685 889932000400 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 889932000401 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889932000402 amphipathic channel; other site 889932000403 Asn-Pro-Ala signature motifs; other site 889932000404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932000405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932000406 DNA binding site [nucleotide binding] 889932000407 domain linker motif; other site 889932000408 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 889932000409 putative dimerization interface [polypeptide binding]; other site 889932000410 putative ligand binding site [chemical binding]; other site 889932000411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932000412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932000413 DNA binding site [nucleotide binding] 889932000414 domain linker motif; other site 889932000415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889932000416 ligand binding site [chemical binding]; other site 889932000417 dimerization interface [polypeptide binding]; other site 889932000418 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932000419 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932000420 Ca binding site [ion binding]; other site 889932000421 active site 889932000422 catalytic site [active] 889932000423 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 889932000424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932000425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932000426 dimer interface [polypeptide binding]; other site 889932000427 conserved gate region; other site 889932000428 putative PBP binding loops; other site 889932000429 ABC-ATPase subunit interface; other site 889932000430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932000431 dimer interface [polypeptide binding]; other site 889932000432 conserved gate region; other site 889932000433 putative PBP binding loops; other site 889932000434 ABC-ATPase subunit interface; other site 889932000435 Predicted integral membrane protein [Function unknown]; Region: COG5521 889932000436 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 889932000437 active site 889932000438 catalytic site [active] 889932000439 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 889932000440 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 889932000441 Walker A/P-loop; other site 889932000442 ATP binding site [chemical binding]; other site 889932000443 Q-loop/lid; other site 889932000444 ABC transporter signature motif; other site 889932000445 Walker B; other site 889932000446 D-loop; other site 889932000447 H-loop/switch region; other site 889932000448 TOBE domain; Region: TOBE_2; cl01440 889932000449 maltose phosphorylase; Provisional; Region: PRK13807 889932000450 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 889932000451 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 889932000452 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 889932000453 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...; Region: GH85_ENGase; cd06547 889932000454 putative active site [active] 889932000455 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 889932000456 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 889932000457 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 889932000458 sugar binding site [chemical binding]; other site 889932000459 PQ loop repeat; Region: PQ-loop; cl12056 889932000460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932000461 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932000462 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932000463 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932000464 active site turn [active] 889932000465 phosphorylation site [posttranslational modification] 889932000466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000467 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 889932000468 HPr interaction site; other site 889932000469 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932000470 active site 889932000471 phosphorylation site [posttranslational modification] 889932000472 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 889932000473 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 889932000474 substrate binding [chemical binding]; other site 889932000475 active site 889932000476 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 889932000477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932000478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932000479 DNA binding site [nucleotide binding] 889932000480 domain linker motif; other site 889932000481 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 889932000482 dimerization interface [polypeptide binding]; other site 889932000483 ligand binding site [chemical binding]; other site 889932000484 sodium binding site [ion binding]; other site 889932000485 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932000486 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932000487 Ca binding site [ion binding]; other site 889932000488 active site 889932000489 catalytic site [active] 889932000490 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 889932000491 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 889932000492 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932000493 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932000494 Ca binding site [ion binding]; other site 889932000495 active site 889932000496 catalytic site [active] 889932000497 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 889932000498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932000499 Helix-turn-helix domains; Region: HTH; cl00088 889932000500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932000501 dimerization interface [polypeptide binding]; other site 889932000502 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889932000503 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 889932000504 putative Ca2+ binding sites [ion binding]; other site 889932000505 domain interaction interfaces; other site 889932000506 putative ligand binding motif; other site 889932000507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889932000508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932000509 non-specific DNA binding site [nucleotide binding]; other site 889932000510 salt bridge; other site 889932000511 sequence-specific DNA binding site [nucleotide binding]; other site 889932000512 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932000513 peptide binding site [polypeptide binding]; other site 889932000514 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 889932000515 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932000516 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932000517 peptide binding site [polypeptide binding]; other site 889932000518 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932000519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932000520 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 889932000521 L-serine binding site [chemical binding]; other site 889932000522 ACT domain interface; other site 889932000523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932000524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932000525 catalytic residue [active] 889932000526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932000527 catalytic core [active] 889932000528 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 889932000529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932000530 active site 889932000531 catalytic tetrad [active] 889932000532 Protein of unknown function (DUF419); Region: DUF419; cl15265 889932000533 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 889932000534 Domain of unknown function (DUF814); Region: DUF814; pfam05670 889932000535 Acetokinase family; Region: Acetate_kinase; cl01029 889932000536 propionate/acetate kinase; Provisional; Region: PRK12379 889932000537 CrcB-like protein; Region: CRCB; cl09114 889932000538 CrcB-like protein; Region: CRCB; cl09114 889932000539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889932000540 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932000541 ABC transporter; Region: ABC_tran_2; pfam12848 889932000542 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932000543 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889932000544 Cobalt transport protein; Region: CbiQ; cl00463 889932000545 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889932000546 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932000547 Walker A/P-loop; other site 889932000548 ATP binding site [chemical binding]; other site 889932000549 Q-loop/lid; other site 889932000550 ABC transporter signature motif; other site 889932000551 Walker B; other site 889932000552 D-loop; other site 889932000553 H-loop/switch region; other site 889932000554 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932000555 Walker A/P-loop; other site 889932000556 ATP binding site [chemical binding]; other site 889932000557 ABC transporter; Region: ABC_tran; pfam00005 889932000558 Q-loop/lid; other site 889932000559 ABC transporter signature motif; other site 889932000560 Walker B; other site 889932000561 D-loop; other site 889932000562 H-loop/switch region; other site 889932000563 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 889932000564 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 889932000565 catalytic residues [active] 889932000566 dimer interface [polypeptide binding]; other site 889932000567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932000568 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932000569 active site 889932000570 catalytic tetrad [active] 889932000571 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 889932000572 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 889932000573 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 889932000574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932000575 non-specific DNA binding site [nucleotide binding]; other site 889932000576 salt bridge; other site 889932000577 sequence-specific DNA binding site [nucleotide binding]; other site 889932000578 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 889932000579 active site 889932000580 trimer interface [polypeptide binding]; other site 889932000581 allosteric site; other site 889932000582 active site lid [active] 889932000583 hexamer (dimer of trimers) interface [polypeptide binding]; other site 889932000584 Peptidase family C69; Region: Peptidase_C69; pfam03577 889932000585 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 889932000586 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 889932000587 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000588 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 889932000589 active site 889932000590 P-loop; other site 889932000591 phosphorylation site [posttranslational modification] 889932000592 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 889932000593 active site 889932000594 P-loop; other site 889932000595 phosphorylation site [posttranslational modification] 889932000596 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889932000597 PRD domain; Region: PRD; cl15445 889932000598 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889932000599 active site 889932000600 P-loop; other site 889932000601 phosphorylation site [posttranslational modification] 889932000602 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 889932000603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932000604 active site 889932000605 phosphorylation site [posttranslational modification] 889932000606 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 889932000607 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 889932000608 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 889932000609 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932000610 DNA binding residues [nucleotide binding] 889932000611 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889932000612 catalytic residues [active] 889932000613 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 889932000614 active site 889932000615 multimer interface [polypeptide binding]; other site 889932000616 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 889932000617 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932000618 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932000619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932000620 DNA-binding site [nucleotide binding]; DNA binding site 889932000621 UTRA domain; Region: UTRA; cl01230 889932000622 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000623 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932000624 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 889932000625 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 889932000626 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 889932000627 active site 889932000628 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 889932000629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932000630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932000631 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932000632 catalytic residue [active] 889932000633 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 889932000634 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 889932000635 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889932000636 substrate binding site [chemical binding]; other site 889932000637 ATP binding site [chemical binding]; other site 889932000638 serine O-acetyltransferase; Region: cysE; TIGR01172 889932000639 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 889932000640 trimer interface [polypeptide binding]; other site 889932000641 active site 889932000642 substrate binding site [chemical binding]; other site 889932000643 CoA binding site [chemical binding]; other site 889932000644 cystathionine beta-lyase; Provisional; Region: PRK07671 889932000645 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 889932000646 homodimer interface [polypeptide binding]; other site 889932000647 substrate-cofactor binding pocket; other site 889932000648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932000649 catalytic residue [active] 889932000650 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 889932000651 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 889932000652 dimer interface [polypeptide binding]; other site 889932000653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932000654 catalytic residue [active] 889932000655 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 889932000656 methionine aminopeptidase; Provisional; Region: PRK08671 889932000657 active site 889932000658 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 889932000659 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 889932000660 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 889932000661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932000662 DNA-binding site [nucleotide binding]; DNA binding site 889932000663 UTRA domain; Region: UTRA; cl01230 889932000664 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932000665 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932000666 Ca binding site [ion binding]; other site 889932000667 active site 889932000668 catalytic site [active] 889932000669 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 889932000670 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932000671 HPr interaction site; other site 889932000672 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932000673 active site 889932000674 phosphorylation site [posttranslational modification] 889932000675 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932000676 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932000677 active site turn [active] 889932000678 phosphorylation site [posttranslational modification] 889932000679 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000680 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932000681 HPr interaction site; other site 889932000682 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932000683 active site 889932000684 phosphorylation site [posttranslational modification] 889932000685 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932000686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932000687 active site turn [active] 889932000688 phosphorylation site [posttranslational modification] 889932000689 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000690 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 889932000691 Flavoprotein; Region: Flavoprotein; cl08021 889932000692 Predicted transcriptional regulator [Transcription]; Region: COG1959 889932000693 Helix-turn-helix domains; Region: HTH; cl00088 889932000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932000695 Helix-turn-helix domains; Region: HTH; cl00088 889932000696 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 889932000697 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 889932000698 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932000699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000700 putative substrate translocation pore; other site 889932000701 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932000702 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932000703 DNA binding residues [nucleotide binding] 889932000704 putative dimer interface [polypeptide binding]; other site 889932000705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 889932000706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932000707 dimer interface [polypeptide binding]; other site 889932000708 phosphorylation site [posttranslational modification] 889932000709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932000710 ATP binding site [chemical binding]; other site 889932000711 Mg2+ binding site [ion binding]; other site 889932000712 G-X-G motif; other site 889932000713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932000714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932000715 active site 889932000716 phosphorylation site [posttranslational modification] 889932000717 intermolecular recognition site; other site 889932000718 dimerization interface [polypeptide binding]; other site 889932000719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932000720 DNA binding site [nucleotide binding] 889932000721 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932000722 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932000723 putative active site [active] 889932000724 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932000725 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932000726 Integrase core domain; Region: rve; cl01316 889932000727 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889932000728 FAD binding domain; Region: FAD_binding_4; pfam01565 889932000729 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 889932000730 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889932000731 synthetase active site [active] 889932000732 NTP binding site [chemical binding]; other site 889932000733 metal binding site [ion binding]; metal-binding site 889932000734 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 889932000735 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 889932000736 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889932000737 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889932000738 Predicted membrane protein [Function unknown]; Region: COG1511 889932000739 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889932000740 Cation efflux family; Region: Cation_efflux; cl00316 889932000741 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 889932000742 legume lectins; Region: lectin_L-type; cl14058 889932000743 homotetramer interaction site [polypeptide binding]; other site 889932000744 carbohydrate binding site [chemical binding]; other site 889932000745 metal binding site [ion binding]; metal-binding site 889932000746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932000747 FtsX-like permease family; Region: FtsX; cl15850 889932000748 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932000749 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932000750 Walker A/P-loop; other site 889932000751 ATP binding site [chemical binding]; other site 889932000752 Q-loop/lid; other site 889932000753 ABC transporter signature motif; other site 889932000754 Walker B; other site 889932000755 D-loop; other site 889932000756 H-loop/switch region; other site 889932000757 CAAX protease self-immunity; Region: Abi; cl00558 889932000758 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932000759 putative peptidoglycan binding site; other site 889932000760 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932000761 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932000762 putative peptidoglycan binding site; other site 889932000763 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 889932000764 lipoyl attachment site [posttranslational modification]; other site 889932000765 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 889932000766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000767 DEAD_2; Region: DEAD_2; pfam06733 889932000768 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000769 Acetokinase family; Region: Acetate_kinase; cl01029 889932000770 propionate/acetate kinase; Provisional; Region: PRK12379 889932000771 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932000772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932000773 Helix-turn-helix domains; Region: HTH; cl00088 889932000774 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889932000775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932000776 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 889932000777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932000778 non-specific DNA binding site [nucleotide binding]; other site 889932000779 salt bridge; other site 889932000780 sequence-specific DNA binding site [nucleotide binding]; other site 889932000781 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 889932000782 SecA binding site; other site 889932000783 Preprotein binding site; other site 889932000784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932000785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 889932000786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932000787 dimer interface [polypeptide binding]; other site 889932000788 conserved gate region; other site 889932000789 putative PBP binding loops; other site 889932000790 ABC-ATPase subunit interface; other site 889932000791 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 889932000792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932000793 dimer interface [polypeptide binding]; other site 889932000794 conserved gate region; other site 889932000795 putative PBP binding loops; other site 889932000796 ABC-ATPase subunit interface; other site 889932000797 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 889932000798 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 889932000799 Walker A/P-loop; other site 889932000800 ATP binding site [chemical binding]; other site 889932000801 Q-loop/lid; other site 889932000802 ABC transporter signature motif; other site 889932000803 Walker B; other site 889932000804 D-loop; other site 889932000805 H-loop/switch region; other site 889932000806 TOBE domain; Region: TOBE_2; cl01440 889932000807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889932000808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932000809 non-specific DNA binding site [nucleotide binding]; other site 889932000810 salt bridge; other site 889932000811 sequence-specific DNA binding site [nucleotide binding]; other site 889932000812 Cupin domain; Region: Cupin_2; cl09118 889932000813 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 889932000814 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889932000815 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932000816 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932000817 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 889932000818 Predicted transcriptional regulators [Transcription]; Region: COG1725 889932000819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932000820 DNA-binding site [nucleotide binding]; DNA binding site 889932000821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889932000822 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932000823 Walker A/P-loop; other site 889932000824 ATP binding site [chemical binding]; other site 889932000825 Q-loop/lid; other site 889932000826 ABC transporter signature motif; other site 889932000827 Walker B; other site 889932000828 D-loop; other site 889932000829 H-loop/switch region; other site 889932000830 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 889932000831 putative catalytic cysteine [active] 889932000832 hypothetical protein; Provisional; Region: PRK08185 889932000833 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 889932000834 intersubunit interface [polypeptide binding]; other site 889932000835 active site 889932000836 zinc binding site [ion binding]; other site 889932000837 Na+ binding site [ion binding]; other site 889932000838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932000839 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932000840 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 889932000841 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 889932000842 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 889932000843 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 889932000844 Peptidase family C69; Region: Peptidase_C69; pfam03577 889932000845 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889932000846 Helix-turn-helix domains; Region: HTH; cl00088 889932000847 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 889932000848 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889932000849 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 889932000850 transaminase; Reviewed; Region: PRK08068 889932000851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932000852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932000853 homodimer interface [polypeptide binding]; other site 889932000854 catalytic residue [active] 889932000855 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932000856 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 889932000857 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 889932000858 Walker A/P-loop; other site 889932000859 ATP binding site [chemical binding]; other site 889932000860 Q-loop/lid; other site 889932000861 ABC transporter signature motif; other site 889932000862 Walker B; other site 889932000863 D-loop; other site 889932000864 H-loop/switch region; other site 889932000865 general secretion pathway protein F; Region: GspF; TIGR02120 889932000866 Helix-turn-helix domains; Region: HTH; cl00088 889932000867 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932000868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000869 putative substrate translocation pore; other site 889932000870 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 889932000871 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889932000872 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932000873 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 889932000874 NAD binding site [chemical binding]; other site 889932000875 dimer interface [polypeptide binding]; other site 889932000876 substrate binding site [chemical binding]; other site 889932000877 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 889932000878 active site 889932000879 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 889932000880 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932000881 active site 889932000882 dimer interface [polypeptide binding]; other site 889932000883 multicopper oxidase; Provisional; Region: PRK10965 889932000884 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889932000885 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889932000886 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 889932000887 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 889932000888 substrate binding site [chemical binding]; other site 889932000889 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 889932000890 Uncharacterized conserved protein [Function unknown]; Region: COG3410 889932000891 Helix-turn-helix domains; Region: HTH; cl00088 889932000892 Rrf2 family protein; Region: rrf2_super; TIGR00738 889932000893 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 889932000894 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889932000895 carboxyltransferase (CT) interaction site; other site 889932000896 biotinylation site [posttranslational modification]; other site 889932000897 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 889932000898 active site 889932000899 tetramer interface [polypeptide binding]; other site 889932000900 short chain dehydrogenase; Validated; Region: PRK06182 889932000901 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 889932000902 NADP binding site [chemical binding]; other site 889932000903 active site 889932000904 steroid binding site; other site 889932000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932000906 dimer interface [polypeptide binding]; other site 889932000907 conserved gate region; other site 889932000908 ABC-ATPase subunit interface; other site 889932000909 NMT1-like family; Region: NMT1_2; cl15260 889932000910 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 889932000911 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 889932000912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000913 Walker A/P-loop; other site 889932000914 ATP binding site [chemical binding]; other site 889932000915 Q-loop/lid; other site 889932000916 ABC transporter signature motif; other site 889932000917 Walker B; other site 889932000918 D-loop; other site 889932000919 H-loop/switch region; other site 889932000920 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 889932000921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932000922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932000923 glycerol kinase; Provisional; Region: glpK; PRK00047 889932000924 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 889932000925 N- and C-terminal domain interface [polypeptide binding]; other site 889932000926 active site 889932000927 MgATP binding site [chemical binding]; other site 889932000928 catalytic site [active] 889932000929 metal binding site [ion binding]; metal-binding site 889932000930 glycerol binding site [chemical binding]; other site 889932000931 homotetramer interface [polypeptide binding]; other site 889932000932 homodimer interface [polypeptide binding]; other site 889932000933 FBP binding site [chemical binding]; other site 889932000934 protein IIAGlc interface [polypeptide binding]; other site 889932000935 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 889932000936 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889932000937 amphipathic channel; other site 889932000938 Asn-Pro-Ala signature motifs; other site 889932000939 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932000940 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 889932000941 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932000942 active site 889932000943 substrate binding site [chemical binding]; other site 889932000944 trimer interface [polypeptide binding]; other site 889932000945 CoA binding site [chemical binding]; other site 889932000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932000947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932000948 putative substrate translocation pore; other site 889932000949 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932000950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932000951 Cupin domain; Region: Cupin_2; cl09118 889932000952 Helix-turn-helix domain; Region: HTH_18; pfam12833 889932000953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932000954 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932000955 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932000956 motif II; other site 889932000957 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932000958 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 889932000959 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932000960 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932000961 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 889932000962 putative metal binding site; other site 889932000963 CAAX protease self-immunity; Region: Abi; cl00558 889932000964 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 889932000965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932000966 ATP binding site [chemical binding]; other site 889932000967 Mg2+ binding site [ion binding]; other site 889932000968 G-X-G motif; other site 889932000969 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932000970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932000971 active site 889932000972 phosphorylation site [posttranslational modification] 889932000973 intermolecular recognition site; other site 889932000974 LytTr DNA-binding domain; Region: LytTR; cl04498 889932000975 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932000976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932000977 active site 889932000978 phosphorylation site [posttranslational modification] 889932000979 intermolecular recognition site; other site 889932000980 dimerization interface [polypeptide binding]; other site 889932000981 LytTr DNA-binding domain; Region: LytTR; cl04498 889932000982 CAAX protease self-immunity; Region: Abi; cl00558 889932000983 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 889932000984 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 889932000985 putative active site [active] 889932000986 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932000987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932000988 Walker A/P-loop; other site 889932000989 ATP binding site [chemical binding]; other site 889932000990 Q-loop/lid; other site 889932000991 ABC transporter signature motif; other site 889932000992 Walker B; other site 889932000993 D-loop; other site 889932000994 H-loop/switch region; other site 889932000995 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 889932000996 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 889932000997 CAAX protease self-immunity; Region: Abi; cl00558 889932000998 CAAX protease self-immunity; Region: Abi; cl00558 889932000999 CAAX protease self-immunity; Region: Abi; cl00558 889932001000 CAAX protease self-immunity; Region: Abi; cl00558 889932001001 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 889932001002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932001003 Family description; Region: UvrD_C_2; cl15862 889932001004 Predicted amidohydrolase [General function prediction only]; Region: COG0388 889932001005 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 889932001006 putative active site [active] 889932001007 catalytic triad [active] 889932001008 putative dimer interface [polypeptide binding]; other site 889932001009 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 889932001010 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 889932001011 active site 889932001012 HIGH motif; other site 889932001013 dimer interface [polypeptide binding]; other site 889932001014 KMSKS motif; other site 889932001015 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932001016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932001017 DNA-binding site [nucleotide binding]; DNA binding site 889932001018 UTRA domain; Region: UTRA; cl01230 889932001019 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932001020 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932001021 N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141 889932001022 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 889932001023 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932001024 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932001025 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932001026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932001027 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932001028 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932001029 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932001030 putative active site [active] 889932001031 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 889932001032 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 889932001033 FMN binding site [chemical binding]; other site 889932001034 active site 889932001035 catalytic residues [active] 889932001036 substrate binding site [chemical binding]; other site 889932001037 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 889932001038 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 889932001039 homodimer interface [polypeptide binding]; other site 889932001040 catalytic residues [active] 889932001041 NAD binding site [chemical binding]; other site 889932001042 substrate binding pocket [chemical binding]; other site 889932001043 flexible flap; other site 889932001044 NAD-dependent deacetylase; Provisional; Region: PRK00481 889932001045 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 889932001046 NAD+ binding site [chemical binding]; other site 889932001047 substrate binding site [chemical binding]; other site 889932001048 putative Zn binding site [ion binding]; other site 889932001049 Protein of unknown function DUF72; Region: DUF72; cl00777 889932001050 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 889932001051 nudix motif; other site 889932001052 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 889932001053 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 889932001054 HIGH motif; other site 889932001055 active site 889932001056 KMSKS motif; other site 889932001057 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 889932001058 tRNA binding surface [nucleotide binding]; other site 889932001059 anticodon binding site; other site 889932001060 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 889932001061 dimer interface [polypeptide binding]; other site 889932001062 putative tRNA-binding site [nucleotide binding]; other site 889932001063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932001064 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 889932001065 putative substrate translocation pore; other site 889932001066 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 889932001067 active site 889932001068 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 889932001069 active site 889932001070 metal binding site [ion binding]; metal-binding site 889932001071 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 889932001072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001073 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 889932001074 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 889932001075 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889932001076 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889932001077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889932001078 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932001079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889932001080 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 889932001081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 889932001082 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 889932001083 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 889932001084 pur operon repressor; Provisional; Region: PRK09213 889932001085 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 889932001086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932001087 active site 889932001088 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 889932001089 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 889932001090 Substrate binding site; other site 889932001091 Mg++ binding site; other site 889932001092 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 889932001093 active site 889932001094 substrate binding site [chemical binding]; other site 889932001095 CoA binding site [chemical binding]; other site 889932001096 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932001097 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 889932001098 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 889932001099 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932001100 active site 889932001101 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889932001102 putative active site [active] 889932001103 sugar phosphate phosphatase; Provisional; Region: PRK10513 889932001104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932001105 active site 889932001106 motif I; other site 889932001107 motif II; other site 889932001108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932001109 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 889932001110 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889932001111 Zn2+ binding site [ion binding]; other site 889932001112 Mg2+ binding site [ion binding]; other site 889932001113 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889932001114 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 889932001115 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 889932001116 CTP synthetase; Validated; Region: pyrG; PRK05380 889932001117 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 889932001118 Catalytic site [active] 889932001119 active site 889932001120 UTP binding site [chemical binding]; other site 889932001121 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 889932001122 active site 889932001123 putative oxyanion hole; other site 889932001124 catalytic triad [active] 889932001125 seryl-tRNA synthetase; Provisional; Region: PRK05431 889932001126 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 889932001127 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 889932001128 dimer interface [polypeptide binding]; other site 889932001129 active site 889932001130 motif 1; other site 889932001131 motif 2; other site 889932001132 motif 3; other site 889932001133 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 889932001134 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 889932001135 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 889932001136 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 889932001137 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 889932001138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 889932001139 YheO-like PAS domain; Region: PAS_6; pfam08348 889932001140 Helix-turn-helix domains; Region: HTH; cl00088 889932001141 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 889932001142 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 889932001143 hinge; other site 889932001144 active site 889932001145 transcription termination factor Rho; Provisional; Region: rho; PRK09376 889932001146 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 889932001147 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 889932001148 RNA binding site [nucleotide binding]; other site 889932001149 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 889932001150 multimer interface [polypeptide binding]; other site 889932001151 Walker A motif; other site 889932001152 ATP binding site [chemical binding]; other site 889932001153 Walker B motif; other site 889932001154 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 889932001155 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 889932001156 active site 889932001157 catalytic site [active] 889932001158 LemA family; Region: LemA; cl00742 889932001159 Peptidase family M48; Region: Peptidase_M48; cl12018 889932001160 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 889932001161 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889932001162 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932001163 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889932001164 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889932001165 ATP binding site [chemical binding]; other site 889932001166 Mg++ binding site [ion binding]; other site 889932001167 motif III; other site 889932001168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932001169 nucleotide binding region [chemical binding]; other site 889932001170 ATP-binding site [chemical binding]; other site 889932001171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932001172 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932001173 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 889932001174 alanine racemase; Reviewed; Region: alr; PRK00053 889932001175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 889932001176 active site 889932001177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889932001178 dimer interface [polypeptide binding]; other site 889932001179 substrate binding site [chemical binding]; other site 889932001180 catalytic residues [active] 889932001181 PemK-like protein; Region: PemK; cl00995 889932001182 K+ potassium transporter; Region: K_trans; cl15781 889932001183 NMT1/THI5 like; Region: NMT1; pfam09084 889932001184 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932001185 substrate binding pocket [chemical binding]; other site 889932001186 membrane-bound complex binding site; other site 889932001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001188 dimer interface [polypeptide binding]; other site 889932001189 conserved gate region; other site 889932001190 putative PBP binding loops; other site 889932001191 ABC-ATPase subunit interface; other site 889932001192 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 889932001193 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 889932001194 Walker A/P-loop; other site 889932001195 ATP binding site [chemical binding]; other site 889932001196 Q-loop/lid; other site 889932001197 ABC transporter signature motif; other site 889932001198 Walker B; other site 889932001199 D-loop; other site 889932001200 H-loop/switch region; other site 889932001201 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 889932001202 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932001203 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932001204 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 889932001205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932001206 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932001207 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 889932001208 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 889932001209 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 889932001210 catalytic site [active] 889932001211 subunit interface [polypeptide binding]; other site 889932001212 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 889932001213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889932001215 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 889932001216 heterotetramer interface [polypeptide binding]; other site 889932001217 active site pocket [active] 889932001218 cleavage site 889932001219 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 889932001220 nucleotide binding site [chemical binding]; other site 889932001221 N-acetyl-L-glutamate binding site [chemical binding]; other site 889932001222 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 889932001223 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889932001224 inhibitor-cofactor binding pocket; inhibition site 889932001225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932001226 catalytic residue [active] 889932001227 ornithine carbamoyltransferase; Validated; Region: PRK02102 889932001228 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889932001229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001230 QueT transporter; Region: QueT; cl01932 889932001231 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932001232 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932001233 peptide binding site [polypeptide binding]; other site 889932001234 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 889932001235 FOG: CBS domain [General function prediction only]; Region: COG0517 889932001236 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 889932001237 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 889932001238 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 889932001239 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889932001240 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 889932001241 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889932001242 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932001243 NAD binding site [chemical binding]; other site 889932001244 dimer interface [polypeptide binding]; other site 889932001245 substrate binding site [chemical binding]; other site 889932001246 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 889932001247 putative active site [active] 889932001248 catalytic residue [active] 889932001249 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 889932001250 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 889932001251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932001252 ATP binding site [chemical binding]; other site 889932001253 putative Mg++ binding site [ion binding]; other site 889932001254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932001255 nucleotide binding region [chemical binding]; other site 889932001256 ATP-binding site [chemical binding]; other site 889932001257 TRCF domain; Region: TRCF; cl04088 889932001258 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889932001259 MatE; Region: MatE; cl10513 889932001260 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889932001261 Septum formation initiator; Region: DivIC; cl11433 889932001262 hypothetical protein; Provisional; Region: PRK08582 889932001263 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 889932001264 RNA binding site [nucleotide binding]; other site 889932001265 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 889932001266 Ligand Binding Site [chemical binding]; other site 889932001267 B3/4 domain; Region: B3_4; cl11458 889932001268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932001269 active site 889932001270 FtsH Extracellular; Region: FtsH_ext; pfam06480 889932001271 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 889932001272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932001273 Walker A motif; other site 889932001274 ATP binding site [chemical binding]; other site 889932001275 Walker B motif; other site 889932001276 arginine finger; other site 889932001277 Peptidase family M41; Region: Peptidase_M41; pfam01434 889932001278 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 889932001279 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 889932001280 dimerization interface [polypeptide binding]; other site 889932001281 domain crossover interface; other site 889932001282 redox-dependent activation switch; other site 889932001283 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 889932001284 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 889932001285 FMN binding site [chemical binding]; other site 889932001286 active site 889932001287 catalytic residues [active] 889932001288 substrate binding site [chemical binding]; other site 889932001289 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 889932001290 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 889932001291 dimer interface [polypeptide binding]; other site 889932001292 putative anticodon binding site; other site 889932001293 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 889932001294 motif 1; other site 889932001295 active site 889932001296 motif 2; other site 889932001297 motif 3; other site 889932001298 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 889932001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932001300 putative substrate translocation pore; other site 889932001301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 889932001302 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932001303 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889932001304 active site 889932001305 metal binding site [ion binding]; metal-binding site 889932001306 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889932001307 Cupin domain; Region: Cupin_2; cl09118 889932001308 Cupin domain; Region: Cupin_2; cl09118 889932001309 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 889932001310 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932001311 active site 889932001312 metal binding site [ion binding]; metal-binding site 889932001313 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932001314 transmembrane helices; other site 889932001315 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 889932001316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001317 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 889932001318 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 889932001319 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 889932001320 active site 889932001321 dimer interface [polypeptide binding]; other site 889932001322 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932001323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932001324 DNA-binding site [nucleotide binding]; DNA binding site 889932001325 UTRA domain; Region: UTRA; cl01230 889932001326 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 889932001327 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 889932001328 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 889932001329 active site 889932001330 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 889932001331 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 889932001332 homodimer interface [polypeptide binding]; other site 889932001333 NAD binding pocket [chemical binding]; other site 889932001334 ATP binding pocket [chemical binding]; other site 889932001335 Mg binding site [ion binding]; other site 889932001336 active-site loop [active] 889932001337 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 889932001338 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 889932001339 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932001340 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 889932001341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932001342 motif II; other site 889932001343 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 889932001344 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 889932001345 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 889932001346 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 889932001347 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 889932001348 RNA binding site [nucleotide binding]; other site 889932001349 hypothetical protein; Provisional; Region: PRK04351 889932001350 SprT homologues; Region: SprT; cl01182 889932001351 homoserine dehydrogenase; Provisional; Region: PRK06349 889932001352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001353 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 889932001354 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 889932001355 homoserine kinase; Provisional; Region: PRK01212 889932001356 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889932001357 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889932001358 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 889932001359 active site 889932001360 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 889932001361 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 889932001362 putative active site [active] 889932001363 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 889932001364 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 889932001365 active pocket/dimerization site; other site 889932001366 active site 889932001367 phosphorylation site [posttranslational modification] 889932001368 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 889932001369 active site 889932001370 phosphorylation site [posttranslational modification] 889932001371 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 889932001372 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 889932001373 Domain of unknown function (DUF956); Region: DUF956; cl01917 889932001374 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 889932001375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932001376 Walker A motif; other site 889932001377 ATP binding site [chemical binding]; other site 889932001378 Walker B motif; other site 889932001379 arginine finger; other site 889932001380 Transcriptional antiterminator [Transcription]; Region: COG3933 889932001381 PRD domain; Region: PRD; cl15445 889932001382 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 889932001383 active pocket/dimerization site; other site 889932001384 active site 889932001385 phosphorylation site [posttranslational modification] 889932001386 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 889932001387 active pocket/dimerization site; other site 889932001388 active site 889932001389 phosphorylation site [posttranslational modification] 889932001390 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 889932001391 active site 889932001392 phosphorylation site [posttranslational modification] 889932001393 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 889932001394 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 889932001395 dimer interface [polypeptide binding]; other site 889932001396 active site 889932001397 CoA binding pocket [chemical binding]; other site 889932001398 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889932001399 carboxyltransferase (CT) interaction site; other site 889932001400 biotinylation site [posttranslational modification]; other site 889932001401 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 889932001402 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932001403 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932001404 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 889932001405 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 889932001406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 889932001407 substrate binding site [chemical binding]; other site 889932001408 trimer interface [polypeptide binding]; other site 889932001409 oxyanion hole (OAH) forming residues; other site 889932001410 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889932001411 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889932001412 Membrane transport protein; Region: Mem_trans; cl09117 889932001413 EamA-like transporter family; Region: EamA; cl01037 889932001414 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932001415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932001416 catalytic core [active] 889932001417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932001418 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 889932001419 active site 889932001420 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 889932001421 trimer interface [polypeptide binding]; other site 889932001422 active site 889932001423 G bulge; other site 889932001424 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 889932001425 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932001426 active site 889932001427 dimer interface [polypeptide binding]; other site 889932001428 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932001429 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 889932001430 trimer interface [polypeptide binding]; other site 889932001431 active site 889932001432 DNA repair protein RadA; Provisional; Region: PRK11823 889932001433 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 889932001434 Walker A motif/ATP binding site; other site 889932001435 ATP binding site [chemical binding]; other site 889932001436 Walker B motif; other site 889932001437 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 889932001438 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 889932001439 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 889932001440 putative active site [active] 889932001441 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 889932001442 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 889932001443 active site 889932001444 HIGH motif; other site 889932001445 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 889932001446 active site 889932001447 KMSKS motif; other site 889932001448 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 889932001449 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 889932001450 active site 889932001451 HIGH motif; other site 889932001452 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 889932001453 KMSKS motif; other site 889932001454 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 889932001455 tRNA binding surface [nucleotide binding]; other site 889932001456 anticodon binding site; other site 889932001457 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 889932001458 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 889932001459 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 889932001460 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889932001461 YacP-like NYN domain; Region: NYN_YacP; cl01491 889932001462 RNA polymerase factor sigma-70; Validated; Region: PRK08295 889932001463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889932001464 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 889932001465 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 889932001466 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 889932001467 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 889932001468 putative homodimer interface [polypeptide binding]; other site 889932001469 KOW motif; Region: KOW; cl00354 889932001470 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932001471 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 889932001472 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 889932001473 23S rRNA interface [nucleotide binding]; other site 889932001474 L7/L12 interface [polypeptide binding]; other site 889932001475 putative thiostrepton binding site; other site 889932001476 L25 interface [polypeptide binding]; other site 889932001477 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 889932001478 mRNA/rRNA interface [nucleotide binding]; other site 889932001479 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 889932001480 23S rRNA interface [nucleotide binding]; other site 889932001481 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 889932001482 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 889932001483 peripheral dimer interface [polypeptide binding]; other site 889932001484 core dimer interface [polypeptide binding]; other site 889932001485 L10 interface [polypeptide binding]; other site 889932001486 L11 interface [polypeptide binding]; other site 889932001487 putative EF-Tu interaction site [polypeptide binding]; other site 889932001488 putative EF-G interaction site [polypeptide binding]; other site 889932001489 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 889932001490 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 889932001491 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 889932001492 Uncharacterized conserved protein [Function unknown]; Region: COG2898 889932001493 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 889932001494 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 889932001495 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 889932001496 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 889932001497 dimer interface [polypeptide binding]; other site 889932001498 putative radical transfer pathway; other site 889932001499 diiron center [ion binding]; other site 889932001500 tyrosyl radical; other site 889932001501 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 889932001502 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 889932001503 Class I ribonucleotide reductase; Region: RNR_I; cd01679 889932001504 active site 889932001505 dimer interface [polypeptide binding]; other site 889932001506 catalytic residues [active] 889932001507 effector binding site; other site 889932001508 R2 peptide binding site; other site 889932001509 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 889932001510 catalytic residues [active] 889932001511 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 889932001512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932001513 S-adenosylmethionine binding site [chemical binding]; other site 889932001514 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 889932001515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932001516 Walker A motif; other site 889932001517 ATP binding site [chemical binding]; other site 889932001518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932001519 Walker B motif; other site 889932001520 arginine finger; other site 889932001521 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 889932001522 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 889932001523 recombination protein RecR; Reviewed; Region: recR; PRK00076 889932001524 RecR protein; Region: RecR; pfam02132 889932001525 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 889932001526 putative active site [active] 889932001527 putative metal-binding site [ion binding]; other site 889932001528 tetramer interface [polypeptide binding]; other site 889932001529 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 889932001530 thymidylate kinase; Validated; Region: tmk; PRK00698 889932001531 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 889932001532 TMP-binding site; other site 889932001533 ATP-binding site [chemical binding]; other site 889932001534 Nitrogen regulatory protein P-II; Region: P-II; cl00412 889932001535 DNA polymerase III subunit delta'; Validated; Region: PRK08058 889932001536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932001537 Protein of unknown function (DUF972); Region: DUF972; pfam06156 889932001538 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 889932001539 Predicted methyltransferases [General function prediction only]; Region: COG0313 889932001540 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 889932001541 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889932001542 active site 889932001543 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 889932001544 active site 889932001545 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 889932001546 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 889932001547 NAD binding site [chemical binding]; other site 889932001548 homodimer interface [polypeptide binding]; other site 889932001549 active site 889932001550 substrate binding site [chemical binding]; other site 889932001551 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 889932001552 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932001553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932001554 catalytic residue [active] 889932001555 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 889932001556 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932001557 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 889932001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001559 dimer interface [polypeptide binding]; other site 889932001560 conserved gate region; other site 889932001561 ABC-ATPase subunit interface; other site 889932001562 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 889932001563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001564 dimer interface [polypeptide binding]; other site 889932001565 conserved gate region; other site 889932001566 ABC-ATPase subunit interface; other site 889932001567 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 889932001568 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 889932001569 Walker A/P-loop; other site 889932001570 ATP binding site [chemical binding]; other site 889932001571 Q-loop/lid; other site 889932001572 ABC transporter signature motif; other site 889932001573 Walker B; other site 889932001574 D-loop; other site 889932001575 H-loop/switch region; other site 889932001576 NMT1-like family; Region: NMT1_2; cl15260 889932001577 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 889932001578 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 889932001579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932001580 Coenzyme A binding pocket [chemical binding]; other site 889932001581 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 889932001582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932001583 Coenzyme A binding pocket [chemical binding]; other site 889932001584 UGMP family protein; Validated; Region: PRK09604 889932001585 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 889932001586 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 889932001587 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889932001588 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932001589 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932001590 ABC transporter; Region: ABC_tran_2; pfam12848 889932001591 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932001592 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 889932001593 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 889932001594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001595 CAAX protease self-immunity; Region: Abi; cl00558 889932001596 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 889932001597 oligomerisation interface [polypeptide binding]; other site 889932001598 mobile loop; other site 889932001599 roof hairpin; other site 889932001600 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 889932001601 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 889932001602 ring oligomerisation interface [polypeptide binding]; other site 889932001603 ATP/Mg binding site [chemical binding]; other site 889932001604 stacking interactions; other site 889932001605 hinge regions; other site 889932001606 Amino acid permease; Region: AA_permease_2; pfam13520 889932001607 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 889932001608 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 889932001609 Mg++ binding site [ion binding]; other site 889932001610 putative catalytic motif [active] 889932001611 substrate binding site [chemical binding]; other site 889932001612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932001613 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 889932001614 Uncharacterized conserved protein [Function unknown]; Region: COG1739 889932001615 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 889932001616 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 889932001617 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 889932001618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932001619 ATP binding site [chemical binding]; other site 889932001620 putative Mg++ binding site [ion binding]; other site 889932001621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932001622 ATP-binding site [chemical binding]; other site 889932001623 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 889932001624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932001625 active site 889932001626 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 889932001627 30S subunit binding site; other site 889932001628 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 889932001629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932001630 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 889932001631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932001632 nucleotide binding region [chemical binding]; other site 889932001633 ATP-binding site [chemical binding]; other site 889932001634 peptide chain release factor 2; Validated; Region: prfB; PRK00578 889932001635 RF-1 domain; Region: RF-1; cl02875 889932001636 RF-1 domain; Region: RF-1; cl02875 889932001637 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 889932001638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932001639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932001640 active site 889932001641 phosphorylation site [posttranslational modification] 889932001642 intermolecular recognition site; other site 889932001643 dimerization interface [polypeptide binding]; other site 889932001644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932001645 DNA binding site [nucleotide binding] 889932001646 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 889932001647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932001648 dimer interface [polypeptide binding]; other site 889932001649 phosphorylation site [posttranslational modification] 889932001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932001651 ATP binding site [chemical binding]; other site 889932001652 Mg2+ binding site [ion binding]; other site 889932001653 G-X-G motif; other site 889932001654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932001655 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 889932001656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001657 dimer interface [polypeptide binding]; other site 889932001658 conserved gate region; other site 889932001659 putative PBP binding loops; other site 889932001660 ABC-ATPase subunit interface; other site 889932001661 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 889932001662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001663 putative PBP binding loops; other site 889932001664 ABC-ATPase subunit interface; other site 889932001665 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 889932001666 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 889932001667 Walker A/P-loop; other site 889932001668 ATP binding site [chemical binding]; other site 889932001669 Q-loop/lid; other site 889932001670 ABC transporter signature motif; other site 889932001671 Walker B; other site 889932001672 D-loop; other site 889932001673 H-loop/switch region; other site 889932001674 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 889932001675 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 889932001676 Walker A/P-loop; other site 889932001677 ATP binding site [chemical binding]; other site 889932001678 Q-loop/lid; other site 889932001679 ABC transporter signature motif; other site 889932001680 Walker B; other site 889932001681 D-loop; other site 889932001682 H-loop/switch region; other site 889932001683 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 889932001684 PhoU domain; Region: PhoU; pfam01895 889932001685 PhoU domain; Region: PhoU; pfam01895 889932001686 PspC domain; Region: PspC; cl00864 889932001687 Membrane protein of unknown function; Region: DUF360; cl00850 889932001688 HPr kinase/phosphorylase; Provisional; Region: PRK05428 889932001689 DRTGG domain; Region: DRTGG; cl12147 889932001690 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 889932001691 Hpr binding site; other site 889932001692 active site 889932001693 homohexamer subunit interaction site [polypeptide binding]; other site 889932001694 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 889932001695 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 889932001696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001697 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 889932001698 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 889932001699 active site 889932001700 tetramer interface; other site 889932001701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 889932001702 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932001703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932001704 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932001705 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 889932001706 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 889932001707 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 889932001708 DXD motif; other site 889932001709 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 889932001710 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 889932001711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932001713 Protein of unknown function (DUF421); Region: DUF421; cl00990 889932001714 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 889932001715 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 889932001716 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 889932001717 active site 889932001718 substrate binding site [chemical binding]; other site 889932001719 metal binding site [ion binding]; metal-binding site 889932001720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 889932001721 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932001722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932001723 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932001724 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 889932001725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932001726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932001727 putative substrate translocation pore; other site 889932001728 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932001729 excinuclease ABC subunit B; Provisional; Region: PRK05298 889932001730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932001731 ATP binding site [chemical binding]; other site 889932001732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932001733 nucleotide binding region [chemical binding]; other site 889932001734 ATP-binding site [chemical binding]; other site 889932001735 Ultra-violet resistance protein B; Region: UvrB; pfam12344 889932001736 UvrB/uvrC motif; Region: UVR; pfam02151 889932001737 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 889932001738 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889932001739 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889932001740 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 889932001741 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 889932001742 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 889932001743 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 889932001744 ANP binding site [chemical binding]; other site 889932001745 Substrate Binding Site II [chemical binding]; other site 889932001746 Substrate Binding Site I [chemical binding]; other site 889932001747 argininosuccinate lyase; Provisional; Region: PRK00855 889932001748 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 889932001749 active sites [active] 889932001750 tetramer interface [polypeptide binding]; other site 889932001751 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 889932001752 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 889932001753 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 889932001754 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 889932001755 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 889932001756 phosphate binding site [ion binding]; other site 889932001757 putative substrate binding pocket [chemical binding]; other site 889932001758 dimer interface [polypeptide binding]; other site 889932001759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 889932001760 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 889932001761 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932001762 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932001763 peptide binding site [polypeptide binding]; other site 889932001764 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 889932001765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001766 Clp protease; Region: CLP_protease; pfam00574 889932001767 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 889932001768 oligomer interface [polypeptide binding]; other site 889932001769 active site residues [active] 889932001770 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 889932001771 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 889932001772 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 889932001773 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 889932001774 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 889932001775 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 889932001776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001777 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 889932001778 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889932001779 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 889932001780 Phosphoglycerate kinase; Region: PGK; pfam00162 889932001781 substrate binding site [chemical binding]; other site 889932001782 hinge regions; other site 889932001783 ADP binding site [chemical binding]; other site 889932001784 catalytic site [active] 889932001785 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 889932001786 substrate binding site [chemical binding]; other site 889932001787 dimer interface [polypeptide binding]; other site 889932001788 catalytic triad [active] 889932001789 enolase; Provisional; Region: eno; PRK00077 889932001790 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 889932001791 dimer interface [polypeptide binding]; other site 889932001792 metal binding site [ion binding]; metal-binding site 889932001793 substrate binding pocket [chemical binding]; other site 889932001794 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 889932001795 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 889932001796 Cl- selectivity filter; other site 889932001797 Cl- binding residues [ion binding]; other site 889932001798 pore gating glutamate residue; other site 889932001799 dimer interface [polypeptide binding]; other site 889932001800 H+/Cl- coupling transport residue; other site 889932001801 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932001802 Preprotein translocase SecG subunit; Region: SecG; cl09123 889932001803 Esterase/lipase [General function prediction only]; Region: COG1647 889932001804 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 889932001805 ribonuclease R; Region: RNase_R; TIGR02063 889932001806 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889932001807 RNB domain; Region: RNB; pfam00773 889932001808 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 889932001809 RNA binding site [nucleotide binding]; other site 889932001810 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 889932001811 SmpB-tmRNA interface; other site 889932001812 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932001813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932001814 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932001815 substrate binding pocket [chemical binding]; other site 889932001816 membrane-bound complex binding site; other site 889932001817 hinge residues; other site 889932001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932001819 dimer interface [polypeptide binding]; other site 889932001820 conserved gate region; other site 889932001821 putative PBP binding loops; other site 889932001822 ABC-ATPase subunit interface; other site 889932001823 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889932001824 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889932001825 Walker A/P-loop; other site 889932001826 ATP binding site [chemical binding]; other site 889932001827 Q-loop/lid; other site 889932001828 ABC transporter signature motif; other site 889932001829 Walker B; other site 889932001830 D-loop; other site 889932001831 H-loop/switch region; other site 889932001832 Scramblase; Region: Scramblase; cl02043 889932001833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932001834 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932001835 active site 889932001836 motif I; other site 889932001837 motif II; other site 889932001838 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932001839 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 889932001840 ligand binding site [chemical binding]; other site 889932001841 active site 889932001842 UGI interface [polypeptide binding]; other site 889932001843 catalytic site [active] 889932001844 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 889932001845 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 889932001846 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 889932001847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932001848 Coenzyme A binding pocket [chemical binding]; other site 889932001849 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932001850 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 889932001851 active site 889932001852 catalytic site [active] 889932001853 substrate binding site [chemical binding]; other site 889932001854 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 889932001855 active site 889932001856 putative catalytic site [active] 889932001857 DNA binding site [nucleotide binding] 889932001858 putative phosphate binding site [ion binding]; other site 889932001859 metal binding site A [ion binding]; metal-binding site 889932001860 AP binding site [nucleotide binding]; other site 889932001861 metal binding site B [ion binding]; metal-binding site 889932001862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932001863 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 889932001864 FAD binding domain; Region: FAD_binding_4; pfam01565 889932001865 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 889932001866 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932001867 Helix-turn-helix domains; Region: HTH; cl00088 889932001868 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 889932001869 Uncharacterized conserved protein [Function unknown]; Region: COG1624 889932001870 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 889932001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 889932001872 YbbR-like protein; Region: YbbR; pfam07949 889932001873 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 889932001874 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 889932001875 active site 889932001876 substrate binding site [chemical binding]; other site 889932001877 metal binding site [ion binding]; metal-binding site 889932001878 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 889932001879 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 889932001880 glutaminase active site [active] 889932001881 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 889932001882 dimer interface [polypeptide binding]; other site 889932001883 active site 889932001884 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 889932001885 dimer interface [polypeptide binding]; other site 889932001886 active site 889932001887 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 889932001888 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 889932001889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932001890 active site 889932001891 motif I; other site 889932001892 motif II; other site 889932001893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932001894 Helix-turn-helix domains; Region: HTH; cl00088 889932001895 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 889932001896 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 889932001897 active site 889932001898 catalytic residues [active] 889932001899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932001900 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932001901 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 889932001902 dimer interface [polypeptide binding]; other site 889932001903 FMN binding site [chemical binding]; other site 889932001904 NADPH bind site [chemical binding]; other site 889932001905 H+ Antiporter protein; Region: 2A0121; TIGR00900 889932001906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932001907 putative substrate translocation pore; other site 889932001908 glycerol kinase; Provisional; Region: glpK; PRK00047 889932001909 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 889932001910 N- and C-terminal domain interface [polypeptide binding]; other site 889932001911 active site 889932001912 MgATP binding site [chemical binding]; other site 889932001913 catalytic site [active] 889932001914 metal binding site [ion binding]; metal-binding site 889932001915 glycerol binding site [chemical binding]; other site 889932001916 homotetramer interface [polypeptide binding]; other site 889932001917 homodimer interface [polypeptide binding]; other site 889932001918 FBP binding site [chemical binding]; other site 889932001919 protein IIAGlc interface [polypeptide binding]; other site 889932001920 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889932001921 putative catalytic residues [active] 889932001922 thiol/disulfide switch; other site 889932001923 VanZ like family; Region: VanZ; cl01971 889932001924 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 889932001925 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 889932001926 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 889932001927 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 889932001928 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 889932001929 putative domain interface [polypeptide binding]; other site 889932001930 putative active site [active] 889932001931 catalytic site [active] 889932001932 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 889932001933 putative domain interface [polypeptide binding]; other site 889932001934 putative active site [active] 889932001935 catalytic site [active] 889932001936 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 889932001937 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 889932001938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932001939 LicD family; Region: LicD; cl01378 889932001940 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889932001941 Helix-turn-helix domains; Region: HTH; cl00088 889932001942 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 889932001943 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 889932001944 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889932001945 PYR/PP interface [polypeptide binding]; other site 889932001946 dimer interface [polypeptide binding]; other site 889932001947 tetramer interface [polypeptide binding]; other site 889932001948 TPP binding site [chemical binding]; other site 889932001949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932001950 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889932001951 TPP-binding site [chemical binding]; other site 889932001952 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 889932001953 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889932001954 PYR/PP interface [polypeptide binding]; other site 889932001955 dimer interface [polypeptide binding]; other site 889932001956 tetramer interface [polypeptide binding]; other site 889932001957 TPP binding site [chemical binding]; other site 889932001958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932001959 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889932001960 TPP-binding site [chemical binding]; other site 889932001961 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 889932001962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932001963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932001964 Helix-turn-helix domains; Region: HTH; cl00088 889932001965 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 889932001966 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889932001967 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 889932001968 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 889932001969 OpgC protein; Region: OpgC_C; cl00792 889932001970 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889932001971 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 889932001972 catalytic triad [active] 889932001973 catalytic triad [active] 889932001974 oxyanion hole [active] 889932001975 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 889932001976 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 889932001977 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 889932001978 OsmC-like protein; Region: OsmC; cl00767 889932001979 amino acid transporter; Region: 2A0306; TIGR00909 889932001980 Spore germination protein; Region: Spore_permease; cl15802 889932001981 Spore germination protein; Region: Spore_permease; cl15802 889932001982 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 889932001983 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 889932001984 substrate binding site [chemical binding]; other site 889932001985 ATP binding site [chemical binding]; other site 889932001986 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 889932001987 active site 889932001988 Ap4A binding cleft/pocket [chemical binding]; other site 889932001989 P4 phosphate binding site; other site 889932001990 nudix motif; other site 889932001991 putative P2/P3 phosphate binding site [ion binding]; other site 889932001992 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 889932001993 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 889932001994 catalytic site [active] 889932001995 G-X2-G-X-G-K; other site 889932001996 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889932001997 metal binding site 2 [ion binding]; metal-binding site 889932001998 putative DNA binding helix; other site 889932001999 metal binding site 1 [ion binding]; metal-binding site 889932002000 dimer interface [polypeptide binding]; other site 889932002001 structural Zn2+ binding site [ion binding]; other site 889932002002 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889932002003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932002004 motif II; other site 889932002005 aromatic amino acid aminotransferase; Validated; Region: PRK07309 889932002006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932002007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932002008 homodimer interface [polypeptide binding]; other site 889932002009 catalytic residue [active] 889932002010 D-lactate dehydrogenase; Validated; Region: PRK08605 889932002011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889932002013 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889932002014 Walker A/P-loop; other site 889932002015 ATP binding site [chemical binding]; other site 889932002016 Q-loop/lid; other site 889932002017 ABC transporter signature motif; other site 889932002018 Walker B; other site 889932002019 D-loop; other site 889932002020 H-loop/switch region; other site 889932002021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932002022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932002023 substrate binding pocket [chemical binding]; other site 889932002024 membrane-bound complex binding site; other site 889932002025 hinge residues; other site 889932002026 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889932002027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932002028 dimer interface [polypeptide binding]; other site 889932002029 conserved gate region; other site 889932002030 putative PBP binding loops; other site 889932002031 ABC-ATPase subunit interface; other site 889932002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932002033 dimer interface [polypeptide binding]; other site 889932002034 conserved gate region; other site 889932002035 putative PBP binding loops; other site 889932002036 ABC-ATPase subunit interface; other site 889932002037 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932002038 HPr interaction site; other site 889932002039 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932002040 active site 889932002041 phosphorylation site [posttranslational modification] 889932002042 CAT RNA binding domain; Region: CAT_RBD; cl03904 889932002043 transcriptional antiterminator BglG; Provisional; Region: PRK09772 889932002044 PRD domain; Region: PRD; cl15445 889932002045 PRD domain; Region: PRD; cl15445 889932002046 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932002047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932002048 active site turn [active] 889932002049 phosphorylation site [posttranslational modification] 889932002050 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932002051 YdjC-like protein; Region: YdjC; cl01344 889932002052 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 889932002053 Spore germination protein; Region: Spore_permease; cl15802 889932002054 Helix-turn-helix domains; Region: HTH; cl00088 889932002055 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932002056 Helix-turn-helix domains; Region: HTH; cl00088 889932002057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932002059 putative substrate translocation pore; other site 889932002060 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889932002061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932002062 Helix-turn-helix domains; Region: HTH; cl00088 889932002063 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 889932002064 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 889932002065 HflX GTPase family; Region: HflX; cd01878 889932002066 G1 box; other site 889932002067 GTP/Mg2+ binding site [chemical binding]; other site 889932002068 Switch I region; other site 889932002069 G2 box; other site 889932002070 G3 box; other site 889932002071 Switch II region; other site 889932002072 G4 box; other site 889932002073 G5 box; other site 889932002074 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 889932002075 nudix motif; other site 889932002076 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 889932002077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932002078 catalytic core [active] 889932002079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932002080 catalytic core [active] 889932002081 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932002082 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932002083 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889932002084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932002086 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 889932002087 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 889932002088 putative active site [active] 889932002089 nucleotide binding site [chemical binding]; other site 889932002090 nudix motif; other site 889932002091 putative metal binding site [ion binding]; other site 889932002092 transcriptional antiterminator BglG; Provisional; Region: PRK09772 889932002093 CAT RNA binding domain; Region: CAT_RBD; cl03904 889932002094 PRD domain; Region: PRD; cl15445 889932002095 PRD domain; Region: PRD; cl15445 889932002096 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 889932002097 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932002098 active site turn [active] 889932002099 phosphorylation site [posttranslational modification] 889932002100 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932002101 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932002102 HPr interaction site; other site 889932002103 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932002104 active site 889932002105 phosphorylation site [posttranslational modification] 889932002106 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932002107 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889932002108 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 889932002109 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 889932002110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002111 Family description; Region: UvrD_C_2; cl15862 889932002112 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 889932002113 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 889932002114 FMN binding site [chemical binding]; other site 889932002115 substrate binding site [chemical binding]; other site 889932002116 putative catalytic residue [active] 889932002117 pantothenate kinase; Provisional; Region: PRK05439 889932002118 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 889932002119 ATP-binding site [chemical binding]; other site 889932002120 CoA-binding site [chemical binding]; other site 889932002121 Mg2+-binding site [ion binding]; other site 889932002122 GMP synthase; Reviewed; Region: guaA; PRK00074 889932002123 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 889932002124 AMP/PPi binding site [chemical binding]; other site 889932002125 candidate oxyanion hole; other site 889932002126 catalytic triad [active] 889932002127 potential glutamine specificity residues [chemical binding]; other site 889932002128 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 889932002129 ATP Binding subdomain [chemical binding]; other site 889932002130 Dimerization subdomain; other site 889932002131 Transposase domain (DUF772); Region: DUF772; cl15789 889932002132 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 889932002133 Transposase domain (DUF772); Region: DUF772; cl15789 889932002134 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889932002135 active site 889932002136 DNA binding site [nucleotide binding] 889932002137 Int/Topo IB signature motif; other site 889932002138 KilA-N domain; Region: KilA-N; pfam04383 889932002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002140 non-specific DNA binding site [nucleotide binding]; other site 889932002141 salt bridge; other site 889932002142 sequence-specific DNA binding site [nucleotide binding]; other site 889932002143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932002144 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932002145 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 889932002146 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889932002147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002148 non-specific DNA binding site [nucleotide binding]; other site 889932002149 salt bridge; other site 889932002150 sequence-specific DNA binding site [nucleotide binding]; other site 889932002151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002152 DNA helicase, putative; Region: TIGR00376 889932002153 Family description; Region: UvrD_C_2; cl15862 889932002154 CAAX protease self-immunity; Region: Abi; cl00558 889932002155 Helix-turn-helix domains; Region: HTH; cl00088 889932002156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002157 putative substrate translocation pore; other site 889932002158 hypothetical protein; Provisional; Region: PRK11281 889932002159 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 889932002160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002161 non-specific DNA binding site [nucleotide binding]; other site 889932002162 salt bridge; other site 889932002163 sequence-specific DNA binding site [nucleotide binding]; other site 889932002164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 889932002165 OpgC protein; Region: OpgC_C; cl00792 889932002166 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 889932002167 catalytic triad [active] 889932002168 catalytic triad [active] 889932002169 oxyanion hole [active] 889932002170 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 889932002171 Asp23 family; Region: Asp23; cl00574 889932002172 Asp23 family; Region: Asp23; cl00574 889932002173 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 889932002174 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 889932002175 methionine cluster; other site 889932002176 active site 889932002177 phosphorylation site [posttranslational modification] 889932002178 metal binding site [ion binding]; metal-binding site 889932002179 Peptidase family M1; Region: Peptidase_M1; pfam01433 889932002180 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 889932002181 Zn binding site [ion binding]; other site 889932002182 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 889932002183 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 889932002184 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 889932002185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932002186 ATP binding site [chemical binding]; other site 889932002187 putative Mg++ binding site [ion binding]; other site 889932002188 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932002189 Helix-turn-helix domains; Region: HTH; cl00088 889932002190 Integrase core domain; Region: rve; cl01316 889932002191 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 889932002192 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 889932002193 Int/Topo IB signature motif; other site 889932002194 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 889932002195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932002196 catalytic core [active] 889932002197 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 889932002198 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002199 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002200 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002201 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002202 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002203 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002204 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002205 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002206 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002209 non-specific DNA binding site [nucleotide binding]; other site 889932002210 salt bridge; other site 889932002211 sequence-specific DNA binding site [nucleotide binding]; other site 889932002212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002213 non-specific DNA binding site [nucleotide binding]; other site 889932002214 salt bridge; other site 889932002215 sequence-specific DNA binding site [nucleotide binding]; other site 889932002216 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932002217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932002218 Helix-turn-helix domains; Region: HTH; cl00088 889932002219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932002220 dimerization interface [polypeptide binding]; other site 889932002221 FAD binding domain; Region: FAD_binding_2; pfam00890 889932002222 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 889932002223 FMN-binding domain; Region: FMN_bind; cl01081 889932002224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932002225 Helix-turn-helix domains; Region: HTH; cl00088 889932002226 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932002227 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 889932002228 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 889932002229 putative dimer interface [polypeptide binding]; other site 889932002230 putative anticodon binding site; other site 889932002231 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 889932002232 homodimer interface [polypeptide binding]; other site 889932002233 motif 1; other site 889932002234 motif 2; other site 889932002235 active site 889932002236 motif 3; other site 889932002237 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 889932002238 dimer interface [polypeptide binding]; other site 889932002239 active site 889932002240 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 889932002241 Peptidase family C69; Region: Peptidase_C69; pfam03577 889932002242 Helix-turn-helix domains; Region: HTH; cl00088 889932002243 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 889932002244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932002245 ATP binding site [chemical binding]; other site 889932002246 putative Mg++ binding site [ion binding]; other site 889932002247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932002248 nucleotide binding region [chemical binding]; other site 889932002249 ATP-binding site [chemical binding]; other site 889932002250 RQC domain; Region: RQC; cl09632 889932002251 HRDC domain; Region: HRDC; cl02578 889932002252 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 889932002253 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 889932002254 active site 889932002255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932002256 dimerization interface [polypeptide binding]; other site 889932002257 putative DNA binding site [nucleotide binding]; other site 889932002258 putative Zn2+ binding site [ion binding]; other site 889932002259 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932002260 YibE/F-like protein; Region: YibE_F; cl02259 889932002261 YibE/F-like protein; Region: YibE_F; cl02259 889932002262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932002263 Coenzyme A binding pocket [chemical binding]; other site 889932002264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932002265 catalytic core [active] 889932002266 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932002267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932002268 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 889932002269 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 889932002270 MFS/sugar transport protein; Region: MFS_2; pfam13347 889932002271 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 889932002272 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889932002273 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932002274 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889932002275 aspartate kinase I; Reviewed; Region: PRK08210 889932002276 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 889932002277 putative catalytic residues [active] 889932002278 putative nucleotide binding site [chemical binding]; other site 889932002279 putative aspartate binding site [chemical binding]; other site 889932002280 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889932002281 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 889932002282 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 889932002283 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 889932002284 active site 889932002285 dimer interface [polypeptide binding]; other site 889932002286 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 889932002287 Ligand Binding Site [chemical binding]; other site 889932002288 Molecular Tunnel; other site 889932002289 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 889932002290 AzlC protein; Region: AzlC; cl00570 889932002291 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932002292 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889932002293 DNA binding residues [nucleotide binding] 889932002294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002295 putative substrate translocation pore; other site 889932002296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002297 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 889932002298 DNA binding residues [nucleotide binding] 889932002299 putative dimer interface [polypeptide binding]; other site 889932002300 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 889932002301 Helix-turn-helix domains; Region: HTH; cl00088 889932002302 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 889932002303 FeoA domain; Region: FeoA; cl00838 889932002304 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 889932002305 DNA-binding site [nucleotide binding]; DNA binding site 889932002306 RNA-binding motif; other site 889932002307 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889932002308 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932002309 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932002310 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889932002311 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889932002312 active site 889932002313 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889932002314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889932002315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932002316 Predicted transcriptional regulator [Transcription]; Region: COG1959 889932002317 Helix-turn-helix domains; Region: HTH; cl00088 889932002318 acetolactate synthase; Reviewed; Region: PRK08617 889932002319 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 889932002320 PYR/PP interface [polypeptide binding]; other site 889932002321 dimer interface [polypeptide binding]; other site 889932002322 TPP binding site [chemical binding]; other site 889932002323 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932002324 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 889932002325 TPP-binding site [chemical binding]; other site 889932002326 dimer interface [polypeptide binding]; other site 889932002327 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 889932002328 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 889932002329 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 889932002330 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 889932002331 Substrate-binding site [chemical binding]; other site 889932002332 Substrate specificity [chemical binding]; other site 889932002333 seryl-tRNA synthetase; Provisional; Region: PRK05431 889932002334 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 889932002335 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 889932002336 dimer interface [polypeptide binding]; other site 889932002337 active site 889932002338 motif 1; other site 889932002339 motif 2; other site 889932002340 motif 3; other site 889932002341 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 889932002342 Clp protease ATP binding subunit; Region: clpC; CHL00095 889932002343 Clp amino terminal domain; Region: Clp_N; pfam02861 889932002344 Clp amino terminal domain; Region: Clp_N; pfam02861 889932002345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932002346 Walker A motif; other site 889932002347 ATP binding site [chemical binding]; other site 889932002348 Walker B motif; other site 889932002349 arginine finger; other site 889932002350 UvrB/uvrC motif; Region: UVR; pfam02151 889932002351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932002352 Walker A motif; other site 889932002353 ATP binding site [chemical binding]; other site 889932002354 Walker B motif; other site 889932002355 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932002356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932002357 Helix-turn-helix domains; Region: HTH; cl00088 889932002358 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 889932002359 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 889932002360 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 889932002361 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 889932002362 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 889932002363 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 889932002364 RPB1 interaction site [polypeptide binding]; other site 889932002365 RPB10 interaction site [polypeptide binding]; other site 889932002366 RPB11 interaction site [polypeptide binding]; other site 889932002367 RPB3 interaction site [polypeptide binding]; other site 889932002368 RPB12 interaction site [polypeptide binding]; other site 889932002369 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 889932002370 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 889932002371 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 889932002372 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 889932002373 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 889932002374 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 889932002375 cleft; other site 889932002376 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 889932002377 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 889932002378 DNA binding site [nucleotide binding] 889932002379 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 889932002380 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 889932002381 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 889932002382 S17 interaction site [polypeptide binding]; other site 889932002383 S8 interaction site; other site 889932002384 16S rRNA interaction site [nucleotide binding]; other site 889932002385 streptomycin interaction site [chemical binding]; other site 889932002386 23S rRNA interaction site [nucleotide binding]; other site 889932002387 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 889932002388 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 889932002389 elongation factor G; Reviewed; Region: PRK12739 889932002390 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 889932002391 G1 box; other site 889932002392 putative GEF interaction site [polypeptide binding]; other site 889932002393 GTP/Mg2+ binding site [chemical binding]; other site 889932002394 Switch I region; other site 889932002395 G2 box; other site 889932002396 G3 box; other site 889932002397 Switch II region; other site 889932002398 G4 box; other site 889932002399 G5 box; other site 889932002400 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 889932002401 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 889932002402 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 889932002403 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 889932002404 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 889932002405 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 889932002406 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 889932002407 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 889932002408 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 889932002409 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 889932002410 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 889932002411 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 889932002412 putative translocon binding site; other site 889932002413 protein-rRNA interface [nucleotide binding]; other site 889932002414 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 889932002415 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 889932002416 G-X-X-G motif; other site 889932002417 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 889932002418 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 889932002419 23S rRNA interface [nucleotide binding]; other site 889932002420 5S rRNA interface [nucleotide binding]; other site 889932002421 putative antibiotic binding site [chemical binding]; other site 889932002422 L25 interface [polypeptide binding]; other site 889932002423 L27 interface [polypeptide binding]; other site 889932002424 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 889932002425 23S rRNA interface [nucleotide binding]; other site 889932002426 putative translocon interaction site; other site 889932002427 signal recognition particle (SRP54) interaction site; other site 889932002428 L23 interface [polypeptide binding]; other site 889932002429 trigger factor interaction site; other site 889932002430 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 889932002431 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 889932002432 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 889932002433 KOW motif; Region: KOW; cl00354 889932002434 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 889932002435 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 889932002436 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 889932002437 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 889932002438 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 889932002439 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 889932002440 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889932002441 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 889932002442 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 889932002443 5S rRNA interface [nucleotide binding]; other site 889932002444 L27 interface [polypeptide binding]; other site 889932002445 23S rRNA interface [nucleotide binding]; other site 889932002446 L5 interface [polypeptide binding]; other site 889932002447 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 889932002448 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 889932002449 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 889932002450 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 889932002451 23S rRNA binding site [nucleotide binding]; other site 889932002452 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 889932002453 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 889932002454 SecY translocase; Region: SecY; pfam00344 889932002455 adenylate kinase; Reviewed; Region: adk; PRK00279 889932002456 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 889932002457 AMP-binding site [chemical binding]; other site 889932002458 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 889932002459 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 889932002460 rRNA binding site [nucleotide binding]; other site 889932002461 predicted 30S ribosome binding site; other site 889932002462 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 889932002463 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 889932002464 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 889932002465 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 889932002466 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 889932002467 alphaNTD homodimer interface [polypeptide binding]; other site 889932002468 alphaNTD - beta interaction site [polypeptide binding]; other site 889932002469 alphaNTD - beta' interaction site [polypeptide binding]; other site 889932002470 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 889932002471 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 889932002472 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889932002473 substrate binding pocket [chemical binding]; other site 889932002474 chain length determination region; other site 889932002475 substrate-Mg2+ binding site; other site 889932002476 catalytic residues [active] 889932002477 aspartate-rich region 1; other site 889932002478 active site lid residues [active] 889932002479 aspartate-rich region 2; other site 889932002480 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 889932002481 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 889932002482 trimer interface [polypeptide binding]; other site 889932002483 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 889932002484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932002485 FMN-binding domain; Region: FMN_bind; cl01081 889932002486 FMN-binding domain; Region: FMN_bind; cl01081 889932002487 ApbE family; Region: ApbE; cl00643 889932002488 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 889932002489 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932002490 Walker A/P-loop; other site 889932002491 ATP binding site [chemical binding]; other site 889932002492 Q-loop/lid; other site 889932002493 ABC transporter signature motif; other site 889932002494 Walker B; other site 889932002495 D-loop; other site 889932002496 H-loop/switch region; other site 889932002497 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 889932002498 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932002499 Walker A/P-loop; other site 889932002500 ATP binding site [chemical binding]; other site 889932002501 Q-loop/lid; other site 889932002502 ABC transporter signature motif; other site 889932002503 Walker B; other site 889932002504 D-loop; other site 889932002505 H-loop/switch region; other site 889932002506 Cobalt transport protein; Region: CbiQ; cl00463 889932002507 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 889932002508 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 889932002509 dimerization interface 3.5A [polypeptide binding]; other site 889932002510 active site 889932002511 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 889932002512 23S rRNA interface [nucleotide binding]; other site 889932002513 L3 interface [polypeptide binding]; other site 889932002514 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 889932002515 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932002516 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 889932002517 transketolase; Reviewed; Region: PRK05899 889932002518 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 889932002519 TPP-binding site [chemical binding]; other site 889932002520 dimer interface [polypeptide binding]; other site 889932002521 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889932002522 PYR/PP interface [polypeptide binding]; other site 889932002523 dimer interface [polypeptide binding]; other site 889932002524 TPP binding site [chemical binding]; other site 889932002525 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 889932002526 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 889932002527 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 889932002528 shikimate binding site; other site 889932002529 NAD(P) binding site [chemical binding]; other site 889932002530 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 889932002531 NeuB family; Region: NeuB; cl00496 889932002532 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 889932002533 active site 889932002534 dimer interface [polypeptide binding]; other site 889932002535 metal binding site [ion binding]; metal-binding site 889932002536 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889932002537 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932002538 transmembrane helices; other site 889932002539 Domain of unknown function DUF59; Region: DUF59; cl00941 889932002540 Fumarase C-terminus; Region: Fumerase_C; cl00795 889932002541 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 889932002542 Cupin domain; Region: Cupin_2; cl09118 889932002543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889932002544 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 889932002545 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 889932002546 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 889932002547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889932002548 ABC-ATPase subunit interface; other site 889932002549 dimer interface [polypeptide binding]; other site 889932002550 putative PBP binding regions; other site 889932002551 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 889932002552 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 889932002553 metal binding site [ion binding]; metal-binding site 889932002554 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 889932002555 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889932002556 dimer interface [polypeptide binding]; other site 889932002557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932002558 NAD binding site [chemical binding]; other site 889932002559 substrate binding site [chemical binding]; other site 889932002560 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889932002561 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932002562 transmembrane helices; other site 889932002563 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 889932002564 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 889932002565 Malic enzyme, N-terminal domain; Region: malic; pfam00390 889932002566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002567 NAD(P) binding pocket [chemical binding]; other site 889932002568 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 889932002569 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 889932002570 putative active site [active] 889932002571 (T/H)XGH motif; other site 889932002572 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 889932002573 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889932002574 citrate lyase, alpha subunit; Region: citF; TIGR01584 889932002575 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 889932002576 fumarate hydratase; Reviewed; Region: fumC; PRK00485 889932002577 Class II fumarases; Region: Fumarase_classII; cd01362 889932002578 active site 889932002579 tetramer interface [polypeptide binding]; other site 889932002580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002581 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 889932002582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002583 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 889932002584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932002585 Helix-turn-helix domains; Region: HTH; cl00088 889932002586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932002587 dimerization interface [polypeptide binding]; other site 889932002588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932002589 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932002590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932002591 Helix-turn-helix domains; Region: HTH; cl00088 889932002592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932002593 dimerization interface [polypeptide binding]; other site 889932002594 malate dehydrogenase; Provisional; Region: PRK13529 889932002595 Malic enzyme, N-terminal domain; Region: malic; pfam00390 889932002596 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 889932002597 NAD(P) binding site [chemical binding]; other site 889932002598 Membrane transport protein; Region: Mem_trans; cl09117 889932002599 amino acid transporter; Region: 2A0306; TIGR00909 889932002600 Spore germination protein; Region: Spore_permease; cl15802 889932002601 Spore germination protein; Region: Spore_permease; cl15802 889932002602 Spore germination protein; Region: Spore_permease; cl15802 889932002603 Predicted membrane protein [Function unknown]; Region: COG4684 889932002604 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 889932002605 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932002606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889932002607 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 889932002608 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 889932002609 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 889932002610 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932002611 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 889932002612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002613 Walker A/P-loop; other site 889932002614 ATP binding site [chemical binding]; other site 889932002615 Q-loop/lid; other site 889932002616 ABC transporter signature motif; other site 889932002617 Walker B; other site 889932002618 D-loop; other site 889932002619 H-loop/switch region; other site 889932002620 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 889932002621 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932002622 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 889932002623 Walker A/P-loop; other site 889932002624 ATP binding site [chemical binding]; other site 889932002625 Q-loop/lid; other site 889932002626 ABC transporter signature motif; other site 889932002627 Walker B; other site 889932002628 D-loop; other site 889932002629 H-loop/switch region; other site 889932002630 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889932002631 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 889932002632 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889932002633 substrate binding pocket [chemical binding]; other site 889932002634 chain length determination region; other site 889932002635 substrate-Mg2+ binding site; other site 889932002636 catalytic residues [active] 889932002637 aspartate-rich region 1; other site 889932002638 active site lid residues [active] 889932002639 aspartate-rich region 2; other site 889932002640 UbiA prenyltransferase family; Region: UbiA; cl00337 889932002641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 889932002642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002643 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932002644 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 889932002645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932002646 active site 889932002647 hypothetical protein; Provisional; Region: PRK04164 889932002648 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 889932002649 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 889932002650 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932002651 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 889932002652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002653 Family description; Region: UvrD_C_2; cl15862 889932002654 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 889932002655 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 889932002656 nucleotide binding pocket [chemical binding]; other site 889932002657 K-X-D-G motif; other site 889932002658 catalytic site [active] 889932002659 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 889932002660 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 889932002661 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 889932002662 Dimer interface [polypeptide binding]; other site 889932002663 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 889932002664 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 889932002665 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 889932002666 Amidase; Region: Amidase; cl11426 889932002667 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 889932002668 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 889932002669 GatB domain; Region: GatB_Yqey; cl11497 889932002670 putative lipid kinase; Reviewed; Region: PRK13055 889932002671 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889932002672 TRAM domain; Region: TRAM; cl01282 889932002673 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 889932002674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932002675 S-adenosylmethionine binding site [chemical binding]; other site 889932002676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932002677 Helix-turn-helix domains; Region: HTH; cl00088 889932002678 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 889932002679 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932002680 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932002681 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932002682 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932002683 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889932002684 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932002685 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932002686 putative active site [active] 889932002687 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 889932002688 active site 889932002689 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 889932002690 DNA-binding site [nucleotide binding]; DNA binding site 889932002691 RNA-binding motif; other site 889932002692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 889932002693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002694 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889932002695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002696 ATP binding site [chemical binding]; other site 889932002697 putative Mg++ binding site [ion binding]; other site 889932002698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932002699 nucleotide binding region [chemical binding]; other site 889932002700 ATP-binding site [chemical binding]; other site 889932002701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932002702 Ligand Binding Site [chemical binding]; other site 889932002703 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932002704 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 889932002705 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932002706 glutamate dehydrogenase; Provisional; Region: PRK09414 889932002707 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 889932002708 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 889932002709 NAD(P) binding site [chemical binding]; other site 889932002710 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932002711 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 889932002712 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 889932002713 active site 889932002714 homodimer interface [polypeptide binding]; other site 889932002715 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 889932002716 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889932002717 amphipathic channel; other site 889932002718 Asn-Pro-Ala signature motifs; other site 889932002719 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 889932002720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002721 UDP-galactopyranose mutase; Region: GLF; pfam03275 889932002722 Chain length determinant protein; Region: Wzz; cl15801 889932002723 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 889932002724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 889932002725 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 889932002726 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 889932002727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889932002728 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889932002729 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889932002730 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 889932002731 Probable Catalytic site; other site 889932002732 MatE; Region: MatE; cl10513 889932002733 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889932002734 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 889932002735 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 889932002736 active site 889932002737 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 889932002738 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 889932002739 NAD binding site [chemical binding]; other site 889932002740 substrate binding site [chemical binding]; other site 889932002741 homodimer interface [polypeptide binding]; other site 889932002742 active site 889932002743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889932002744 DNA binding site [nucleotide binding] 889932002745 Int/Topo IB signature motif; other site 889932002746 active site 889932002747 Chain length determinant protein; Region: Wzz; cl15801 889932002748 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 889932002749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932002750 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 889932002751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 889932002753 NAD(P) binding site [chemical binding]; other site 889932002754 active site 889932002755 Bacterial sugar transferase; Region: Bac_transf; cl00939 889932002756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932002757 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 889932002758 putative ADP-binding pocket [chemical binding]; other site 889932002759 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932002760 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 889932002761 putative ADP-binding pocket [chemical binding]; other site 889932002762 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 889932002763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889932002764 active site 889932002765 MatE; Region: MatE; cl10513 889932002766 RelB antitoxin; Region: RelB; cl01171 889932002767 Helix-turn-helix domains; Region: HTH; cl00088 889932002768 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932002769 Integrase core domain; Region: rve; cl01316 889932002770 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932002771 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 889932002772 RNAase interaction site [polypeptide binding]; other site 889932002773 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889932002774 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 889932002775 Probable Catalytic site; other site 889932002776 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 889932002777 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 889932002778 Probable Catalytic site; other site 889932002779 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 889932002780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002781 UDP-galactopyranose mutase; Region: GLF; pfam03275 889932002782 OpgC protein; Region: OpgC_C; cl00792 889932002783 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889932002784 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 889932002785 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 889932002786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932002787 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932002788 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 889932002789 legume lectins; Region: lectin_L-type; cd01951 889932002790 homotetramer interaction site [polypeptide binding]; other site 889932002791 carbohydrate binding site [chemical binding]; other site 889932002792 metal binding site [ion binding]; metal-binding site 889932002793 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002794 MucBP domain; Region: MucBP; pfam06458 889932002795 MucBP domain; Region: MucBP; pfam06458 889932002796 MucBP domain; Region: MucBP; pfam06458 889932002797 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 889932002798 Helix-turn-helix domains; Region: HTH; cl00088 889932002799 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889932002800 MatE; Region: MatE; cl10513 889932002801 Bacterial sugar transferase; Region: Bac_transf; cl00939 889932002802 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 889932002803 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 889932002804 RecX family; Region: RecX; cl00936 889932002805 Protein of unknown function (DUF402); Region: DUF402; cl00979 889932002806 NlpC/P60 family; Region: NLPC_P60; cl11438 889932002807 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 889932002808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932002809 non-specific DNA binding site [nucleotide binding]; other site 889932002810 salt bridge; other site 889932002811 sequence-specific DNA binding site [nucleotide binding]; other site 889932002812 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 889932002813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932002814 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889932002815 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932002816 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 889932002817 NAD binding site [chemical binding]; other site 889932002818 dimer interface [polypeptide binding]; other site 889932002819 substrate binding site [chemical binding]; other site 889932002820 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889932002821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889932002822 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 889932002823 active site 889932002824 nucleotide binding site [chemical binding]; other site 889932002825 HIGH motif; other site 889932002826 KMSKS motif; other site 889932002827 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 889932002828 GntP family permease; Region: GntP_permease; pfam02447 889932002829 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 889932002830 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 889932002831 N- and C-terminal domain interface [polypeptide binding]; other site 889932002832 putative active site [active] 889932002833 catalytic site [active] 889932002834 metal binding site [ion binding]; metal-binding site 889932002835 carbohydrate binding site [chemical binding]; other site 889932002836 ATP binding site [chemical binding]; other site 889932002837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002838 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 889932002839 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 889932002840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932002841 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 889932002842 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 889932002843 G1 box; other site 889932002844 putative GEF interaction site [polypeptide binding]; other site 889932002845 GTP/Mg2+ binding site [chemical binding]; other site 889932002846 Switch I region; other site 889932002847 G2 box; other site 889932002848 G3 box; other site 889932002849 Switch II region; other site 889932002850 G4 box; other site 889932002851 G5 box; other site 889932002852 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 889932002853 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002854 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932002855 Helix-turn-helix domains; Region: HTH; cl00088 889932002856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932002857 dimerization interface [polypeptide binding]; other site 889932002858 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 889932002859 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889932002860 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 889932002861 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932002862 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932002863 peptide binding site [polypeptide binding]; other site 889932002864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 889932002865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932002866 dimer interface [polypeptide binding]; other site 889932002867 conserved gate region; other site 889932002868 putative PBP binding loops; other site 889932002869 ABC-ATPase subunit interface; other site 889932002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932002871 dimer interface [polypeptide binding]; other site 889932002872 conserved gate region; other site 889932002873 putative PBP binding loops; other site 889932002874 ABC-ATPase subunit interface; other site 889932002875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 889932002876 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889932002877 Walker A/P-loop; other site 889932002878 ATP binding site [chemical binding]; other site 889932002879 Q-loop/lid; other site 889932002880 ABC transporter signature motif; other site 889932002881 Walker B; other site 889932002882 D-loop; other site 889932002883 H-loop/switch region; other site 889932002884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889932002885 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 889932002886 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 889932002887 Walker A/P-loop; other site 889932002888 ATP binding site [chemical binding]; other site 889932002889 Q-loop/lid; other site 889932002890 ABC transporter signature motif; other site 889932002891 Walker B; other site 889932002892 D-loop; other site 889932002893 H-loop/switch region; other site 889932002894 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 889932002895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932002896 Helix-turn-helix domains; Region: HTH; cl00088 889932002897 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 889932002898 Int/Topo IB signature motif; other site 889932002899 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 889932002900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932002901 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 889932002902 Walker A motif; other site 889932002903 ATP binding site [chemical binding]; other site 889932002904 Walker B motif; other site 889932002905 arginine finger; other site 889932002906 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 889932002907 UvrB/uvrC motif; Region: UVR; pfam02151 889932002908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932002909 Walker A motif; other site 889932002910 ATP binding site [chemical binding]; other site 889932002911 Walker B motif; other site 889932002912 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932002913 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 889932002914 dimerization domain swap beta strand [polypeptide binding]; other site 889932002915 regulatory protein interface [polypeptide binding]; other site 889932002916 active site 889932002917 regulatory phosphorylation site [posttranslational modification]; other site 889932002918 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 889932002919 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 889932002920 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 889932002921 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889932002922 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932002923 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 889932002924 putative ADP-binding pocket [chemical binding]; other site 889932002925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889932002926 Predicted integral membrane protein [Function unknown]; Region: COG0392 889932002927 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 889932002928 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 889932002929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932002930 aromatic amino acid aminotransferase; Validated; Region: PRK07309 889932002931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932002932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932002933 homodimer interface [polypeptide binding]; other site 889932002934 catalytic residue [active] 889932002935 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 889932002936 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 889932002937 Sulfatase; Region: Sulfatase; cl10460 889932002938 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 889932002939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932002940 active site 889932002941 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 889932002942 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932002943 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889932002944 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932002945 active site 889932002946 metal binding site [ion binding]; metal-binding site 889932002947 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 889932002948 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 889932002949 Ferrochelatase; Region: Ferrochelatase; pfam00762 889932002950 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 889932002951 C-terminal domain interface [polypeptide binding]; other site 889932002952 active site 889932002953 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 889932002954 active site 889932002955 N-terminal domain interface [polypeptide binding]; other site 889932002956 S-methylmethionine transporter; Provisional; Region: PRK11387 889932002957 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 889932002958 Spore germination protein; Region: Spore_permease; cl15802 889932002959 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 889932002960 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 889932002961 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932002962 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932002963 S-adenosylmethionine synthetase; Validated; Region: PRK05250 889932002964 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 889932002965 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 889932002966 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 889932002967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932002969 putative substrate translocation pore; other site 889932002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932002971 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932002972 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932002973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932002974 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932002975 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 889932002976 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932002977 hypothetical protein; Provisional; Region: PRK08317 889932002978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932002979 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889932002980 active site 889932002981 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 889932002982 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 889932002983 HIGH motif; other site 889932002984 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889932002985 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 889932002986 active site 889932002987 KMSKS motif; other site 889932002988 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 889932002989 tRNA binding surface [nucleotide binding]; other site 889932002990 MatE; Region: MatE; cl10513 889932002991 stage V sporulation protein B; Region: spore_V_B; TIGR02900 889932002992 MatE; Region: MatE; cl10513 889932002993 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 889932002994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889932002995 RNA binding surface [nucleotide binding]; other site 889932002996 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 889932002997 active site 889932002998 uracil binding [chemical binding]; other site 889932002999 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 889932003000 putative substrate binding site [chemical binding]; other site 889932003001 putative ATP binding site [chemical binding]; other site 889932003002 dipeptidase PepV; Reviewed; Region: PRK07318 889932003003 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 889932003004 active site 889932003005 metal binding site [ion binding]; metal-binding site 889932003006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932003007 Ligand Binding Site [chemical binding]; other site 889932003008 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 889932003009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003010 Walker A/P-loop; other site 889932003011 ATP binding site [chemical binding]; other site 889932003012 Q-loop/lid; other site 889932003013 ABC transporter signature motif; other site 889932003014 Walker B; other site 889932003015 D-loop; other site 889932003016 H-loop/switch region; other site 889932003017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932003018 dimer interface [polypeptide binding]; other site 889932003019 conserved gate region; other site 889932003020 putative PBP binding loops; other site 889932003021 ABC-ATPase subunit interface; other site 889932003022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 889932003023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932003024 dimer interface [polypeptide binding]; other site 889932003025 conserved gate region; other site 889932003026 putative PBP binding loops; other site 889932003027 ABC-ATPase subunit interface; other site 889932003028 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 889932003029 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 889932003030 active site 889932003031 catalytic site [active] 889932003032 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 889932003033 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 889932003034 Substrate-binding site [chemical binding]; other site 889932003035 Substrate specificity [chemical binding]; other site 889932003036 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 889932003037 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 889932003038 Predicted membrane protein [Function unknown]; Region: COG1511 889932003039 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889932003040 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889932003041 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 889932003042 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932003043 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932003044 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932003045 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932003046 Walker A/P-loop; other site 889932003047 ATP binding site [chemical binding]; other site 889932003048 Q-loop/lid; other site 889932003049 ABC transporter signature motif; other site 889932003050 Walker B; other site 889932003051 D-loop; other site 889932003052 H-loop/switch region; other site 889932003053 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 889932003054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003055 Walker A/P-loop; other site 889932003056 ATP binding site [chemical binding]; other site 889932003057 Q-loop/lid; other site 889932003058 ABC transporter signature motif; other site 889932003059 Walker B; other site 889932003060 D-loop; other site 889932003061 H-loop/switch region; other site 889932003062 LytTr DNA-binding domain; Region: LytTR; cl04498 889932003063 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932003064 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 889932003065 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932003066 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 889932003067 DNA binding residues [nucleotide binding] 889932003068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932003069 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932003070 NAD(P) binding site [chemical binding]; other site 889932003071 active site 889932003072 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932003073 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932003074 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932003075 active site 889932003076 motif I; other site 889932003077 motif II; other site 889932003078 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932003079 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 889932003080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889932003081 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932003082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932003083 active site 889932003084 phosphorylation site [posttranslational modification] 889932003085 intermolecular recognition site; other site 889932003086 dimerization interface [polypeptide binding]; other site 889932003087 LytTr DNA-binding domain; Region: LytTR; cl04498 889932003088 CAAX protease self-immunity; Region: Abi; cl00558 889932003089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932003090 Helix-turn-helix domains; Region: HTH; cl00088 889932003091 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 889932003092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003093 Walker A/P-loop; other site 889932003094 ATP binding site [chemical binding]; other site 889932003095 Q-loop/lid; other site 889932003096 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 889932003097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003098 Walker A/P-loop; other site 889932003099 ATP binding site [chemical binding]; other site 889932003100 Q-loop/lid; other site 889932003101 ABC transporter signature motif; other site 889932003102 Walker B; other site 889932003103 D-loop; other site 889932003104 H-loop/switch region; other site 889932003105 GtrA-like protein; Region: GtrA; cl00971 889932003106 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 889932003107 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 889932003108 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 889932003109 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 889932003110 FAD binding site [chemical binding]; other site 889932003111 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 889932003112 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 889932003113 THF binding site; other site 889932003114 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 889932003115 substrate binding site [chemical binding]; other site 889932003116 THF binding site; other site 889932003117 zinc-binding site [ion binding]; other site 889932003118 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 889932003119 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 889932003120 ATP-sulfurylase; Region: ATPS; cd00517 889932003121 active site 889932003122 HXXH motif; other site 889932003123 flexible loop; other site 889932003124 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 889932003125 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 889932003126 ligand-binding site [chemical binding]; other site 889932003127 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 889932003128 DHH family; Region: DHH; pfam01368 889932003129 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 889932003130 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932003131 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932003132 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932003133 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 889932003134 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 889932003135 MatE; Region: MatE; cl10513 889932003136 MatE; Region: MatE; cl10513 889932003137 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932003138 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 889932003139 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 889932003140 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 889932003141 active site 889932003142 HIGH motif; other site 889932003143 KMSK motif region; other site 889932003144 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 889932003145 tRNA binding surface [nucleotide binding]; other site 889932003146 anticodon binding site; other site 889932003147 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932003148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932003149 Walker A/P-loop; other site 889932003150 ATP binding site [chemical binding]; other site 889932003151 Q-loop/lid; other site 889932003152 ABC transporter signature motif; other site 889932003153 Walker B; other site 889932003154 D-loop; other site 889932003155 H-loop/switch region; other site 889932003156 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932003157 FtsX-like permease family; Region: FtsX; cl15850 889932003158 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 889932003159 Transcriptional antiterminator [Transcription]; Region: COG3933 889932003160 PRD domain; Region: PRD; cl15445 889932003161 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 889932003162 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 889932003163 methionine cluster; other site 889932003164 active site 889932003165 phosphorylation site [posttranslational modification] 889932003166 metal binding site [ion binding]; metal-binding site 889932003167 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 889932003168 active site 889932003169 P-loop; other site 889932003170 phosphorylation site [posttranslational modification] 889932003171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932003172 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932003173 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932003174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932003175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932003176 putative substrate translocation pore; other site 889932003177 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889932003178 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889932003179 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889932003180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932003181 DNA-binding site [nucleotide binding]; DNA binding site 889932003182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932003183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932003184 homodimer interface [polypeptide binding]; other site 889932003185 catalytic residue [active] 889932003186 LysE type translocator; Region: LysE; cl00565 889932003187 transaminase; Validated; Region: PRK07324 889932003188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932003190 homodimer interface [polypeptide binding]; other site 889932003191 catalytic residue [active] 889932003192 Arginine repressor [Transcription]; Region: ArgR; COG1438 889932003193 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 889932003194 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 889932003195 Transglycosylase; Region: Transgly; cl07896 889932003196 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 889932003197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932003198 Protein of unknown function (DUF964); Region: DUF964; cl01483 889932003199 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 889932003200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932003201 active site 889932003202 metal binding site [ion binding]; metal-binding site 889932003203 DNA binding site [nucleotide binding] 889932003204 Uncharacterized conserved protein [Function unknown]; Region: COG4717 889932003205 Uncharacterized conserved protein [Function unknown]; Region: COG4717 889932003206 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 889932003207 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 889932003208 generic binding surface II; other site 889932003209 generic binding surface I; other site 889932003210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889932003211 Zn2+ binding site [ion binding]; other site 889932003212 Mg2+ binding site [ion binding]; other site 889932003213 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 889932003214 Active site serine [active] 889932003215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932003216 Helix-turn-helix domains; Region: HTH; cl00088 889932003217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932003218 dimerization interface [polypeptide binding]; other site 889932003219 TIR domain; Region: TIR_2; cl15770 889932003220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932003221 intermolecular recognition site; other site 889932003222 active site 889932003223 dimerization interface [polypeptide binding]; other site 889932003224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932003225 DNA binding site [nucleotide binding] 889932003226 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 889932003227 active site 889932003228 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 889932003229 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 889932003230 Ligand binding site; other site 889932003231 Putative Catalytic site; other site 889932003232 DXD motif; other site 889932003233 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889932003234 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 889932003235 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 889932003236 Ligand binding site; other site 889932003237 Putative Catalytic site; other site 889932003238 DXD motif; other site 889932003239 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 889932003240 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 889932003241 nudix motif; other site 889932003242 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 889932003243 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 889932003244 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 889932003245 catalytic motif [active] 889932003246 Zn binding site [ion binding]; other site 889932003247 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 889932003248 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 889932003249 Lumazine binding domain; Region: Lum_binding; pfam00677 889932003250 Lumazine binding domain; Region: Lum_binding; pfam00677 889932003251 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 889932003252 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 889932003253 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 889932003254 dimerization interface [polypeptide binding]; other site 889932003255 active site 889932003256 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 889932003257 homopentamer interface [polypeptide binding]; other site 889932003258 active site 889932003259 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 889932003260 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 889932003261 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 889932003262 ligand binding site [chemical binding]; other site 889932003263 flexible hinge region; other site 889932003264 Helix-turn-helix domains; Region: HTH; cl00088 889932003265 non-specific DNA interactions [nucleotide binding]; other site 889932003266 DNA binding site [nucleotide binding] 889932003267 sequence specific DNA binding site [nucleotide binding]; other site 889932003268 putative cAMP binding site [chemical binding]; other site 889932003269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932003270 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932003271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932003272 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932003273 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932003274 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932003275 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932003276 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 889932003277 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932003278 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932003279 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 889932003280 PPIC-type PPIASE domain; Region: Rotamase; cl08278 889932003281 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 889932003282 HIT family signature motif; other site 889932003283 catalytic residue [active] 889932003284 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 889932003285 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932003286 Walker A/P-loop; other site 889932003287 ATP binding site [chemical binding]; other site 889932003288 Q-loop/lid; other site 889932003289 ABC transporter signature motif; other site 889932003290 Walker B; other site 889932003291 D-loop; other site 889932003292 H-loop/switch region; other site 889932003293 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 889932003294 Phosphotransferase enzyme family; Region: APH; pfam01636 889932003295 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 889932003296 active site 889932003297 substrate binding site [chemical binding]; other site 889932003298 ATP binding site [chemical binding]; other site 889932003299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932003300 S-adenosylmethionine binding site [chemical binding]; other site 889932003301 Predicted small secreted protein [Function unknown]; Region: COG5584 889932003302 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 889932003303 putative tRNA-binding site [nucleotide binding]; other site 889932003304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003305 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 889932003306 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 889932003307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 889932003308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932003309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889932003310 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 889932003311 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 889932003312 G1 box; other site 889932003313 GTP/Mg2+ binding site [chemical binding]; other site 889932003314 Switch I region; other site 889932003315 G2 box; other site 889932003316 G3 box; other site 889932003317 Switch II region; other site 889932003318 G4 box; other site 889932003319 G5 box; other site 889932003320 Nucleoside recognition; Region: Gate; cl00486 889932003321 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 889932003322 Nucleoside recognition; Region: Gate; cl00486 889932003323 FeoA domain; Region: FeoA; cl00838 889932003324 FeS assembly ATPase SufC; Region: sufC; TIGR01978 889932003325 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 889932003326 Walker A/P-loop; other site 889932003327 ATP binding site [chemical binding]; other site 889932003328 Q-loop/lid; other site 889932003329 ABC transporter signature motif; other site 889932003330 Walker B; other site 889932003331 D-loop; other site 889932003332 H-loop/switch region; other site 889932003333 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 889932003334 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 889932003335 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 889932003336 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 889932003337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932003338 catalytic residue [active] 889932003339 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 889932003340 trimerization site [polypeptide binding]; other site 889932003341 active site 889932003342 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 889932003343 FeS assembly protein SufB; Region: sufB; TIGR01980 889932003344 Domain of unknown function DUF59; Region: DUF59; cl00941 889932003345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932003346 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 889932003347 DNA polymerase I; Provisional; Region: PRK05755 889932003348 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 889932003349 active site 889932003350 metal binding site 1 [ion binding]; metal-binding site 889932003351 putative 5' ssDNA interaction site; other site 889932003352 metal binding site 3; metal-binding site 889932003353 metal binding site 2 [ion binding]; metal-binding site 889932003354 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 889932003355 putative DNA binding site [nucleotide binding]; other site 889932003356 putative metal binding site [ion binding]; other site 889932003357 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 889932003358 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 889932003359 active site 889932003360 DNA binding site [nucleotide binding] 889932003361 catalytic site [active] 889932003362 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 889932003363 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 889932003364 DNA binding site [nucleotide binding] 889932003365 catalytic residue [active] 889932003366 H2TH interface [polypeptide binding]; other site 889932003367 putative catalytic residues [active] 889932003368 turnover-facilitating residue; other site 889932003369 intercalation triad [nucleotide binding]; other site 889932003370 8OG recognition residue [nucleotide binding]; other site 889932003371 putative reading head residues; other site 889932003372 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 889932003373 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889932003374 dephospho-CoA kinase; Region: TIGR00152 889932003375 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 889932003376 CoA-binding site [chemical binding]; other site 889932003377 ATP-binding [chemical binding]; other site 889932003378 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 889932003379 ATP cone domain; Region: ATP-cone; pfam03477 889932003380 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 889932003381 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 889932003382 primosomal protein DnaI; Reviewed; Region: PRK08939 889932003383 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 889932003384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932003385 Walker A motif; other site 889932003386 ATP binding site [chemical binding]; other site 889932003387 Walker B motif; other site 889932003388 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 889932003389 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 889932003390 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 889932003391 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 889932003392 active site 889932003393 dimer interface [polypeptide binding]; other site 889932003394 motif 1; other site 889932003395 motif 2; other site 889932003396 motif 3; other site 889932003397 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 889932003398 anticodon binding site; other site 889932003399 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 889932003400 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 889932003401 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 889932003402 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 889932003403 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 889932003404 23S rRNA binding site [nucleotide binding]; other site 889932003405 L21 binding site [polypeptide binding]; other site 889932003406 L13 binding site [polypeptide binding]; other site 889932003407 recombination factor protein RarA; Reviewed; Region: PRK13342 889932003408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932003409 Walker A motif; other site 889932003410 ATP binding site [chemical binding]; other site 889932003411 Walker B motif; other site 889932003412 arginine finger; other site 889932003413 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 889932003414 Helix-turn-helix domains; Region: HTH; cl00088 889932003415 aspartate racemase; Region: asp_race; TIGR00035 889932003416 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 889932003417 N-glycosyltransferase; Provisional; Region: PRK11204 889932003418 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 889932003419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889932003420 DXD motif; other site 889932003421 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 889932003422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932003423 active site 889932003424 motif I; other site 889932003425 motif II; other site 889932003426 GTPase YqeH; Provisional; Region: PRK13796 889932003427 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 889932003428 GTP/Mg2+ binding site [chemical binding]; other site 889932003429 G4 box; other site 889932003430 G5 box; other site 889932003431 G1 box; other site 889932003432 Switch I region; other site 889932003433 G2 box; other site 889932003434 G3 box; other site 889932003435 Switch II region; other site 889932003436 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 889932003437 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 889932003438 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 889932003439 active site 889932003440 (T/H)XGH motif; other site 889932003441 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 889932003442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889932003443 Zn2+ binding site [ion binding]; other site 889932003444 Mg2+ binding site [ion binding]; other site 889932003445 Oligomerisation domain; Region: Oligomerisation; cl00519 889932003446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932003447 S-adenosylmethionine binding site [chemical binding]; other site 889932003448 hypothetical protein; Provisional; Region: PRK13670 889932003449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889932003450 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 889932003451 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 889932003452 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 889932003453 Predicted membrane protein [Function unknown]; Region: COG3212 889932003454 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 889932003455 Cation efflux family; Region: Cation_efflux; cl00316 889932003456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932003457 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 889932003458 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 889932003459 recombination factor protein RarA; Reviewed; Region: PRK13342 889932003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932003461 Walker A motif; other site 889932003462 ATP binding site [chemical binding]; other site 889932003463 Walker B motif; other site 889932003464 arginine finger; other site 889932003465 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 889932003466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932003467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932003468 active site 889932003469 phosphorylation site [posttranslational modification] 889932003470 intermolecular recognition site; other site 889932003471 dimerization interface [polypeptide binding]; other site 889932003472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932003473 DNA binding site [nucleotide binding] 889932003474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889932003475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 889932003476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932003477 dimer interface [polypeptide binding]; other site 889932003478 phosphorylation site [posttranslational modification] 889932003479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932003480 ATP binding site [chemical binding]; other site 889932003481 Mg2+ binding site [ion binding]; other site 889932003482 G-X-G motif; other site 889932003483 UbiA prenyltransferase family; Region: UbiA; cl00337 889932003484 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 889932003485 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 889932003486 Walker A/P-loop; other site 889932003487 ATP binding site [chemical binding]; other site 889932003488 Q-loop/lid; other site 889932003489 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 889932003490 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 889932003491 ABC transporter signature motif; other site 889932003492 Walker B; other site 889932003493 D-loop; other site 889932003494 H-loop/switch region; other site 889932003495 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 889932003496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932003497 active site 889932003498 metal binding site [ion binding]; metal-binding site 889932003499 DNA binding site [nucleotide binding] 889932003500 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 889932003501 SdpI/YhfL protein family; Region: SdpI; pfam13630 889932003502 OxaA-like protein precursor; Provisional; Region: PRK02463 889932003503 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 889932003504 Acylphosphatase; Region: Acylphosphatase; cl00551 889932003505 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 889932003506 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 889932003507 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889932003508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932003509 Helix-turn-helix domains; Region: HTH; cl00088 889932003510 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 889932003511 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 889932003512 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 889932003513 dimer interface [polypeptide binding]; other site 889932003514 motif 1; other site 889932003515 active site 889932003516 motif 2; other site 889932003517 motif 3; other site 889932003518 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 889932003519 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 889932003520 putative tRNA-binding site [nucleotide binding]; other site 889932003521 B3/4 domain; Region: B3_4; cl11458 889932003522 tRNA synthetase B5 domain; Region: B5; cl08394 889932003523 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 889932003524 dimer interface [polypeptide binding]; other site 889932003525 motif 1; other site 889932003526 motif 3; other site 889932003527 motif 2; other site 889932003528 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 889932003529 YceG-like family; Region: YceG; pfam02618 889932003530 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 889932003531 dimerization interface [polypeptide binding]; other site 889932003532 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 889932003533 Pyrimidine base specificity; other site 889932003534 Sugar specificity; other site 889932003535 ATP-binding site [chemical binding]; other site 889932003536 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 889932003537 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 889932003538 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 889932003539 LytTr DNA-binding domain; Region: LytTR; cl04498 889932003540 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 889932003541 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 889932003542 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 889932003543 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932003544 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 889932003545 Rhomboid family; Region: Rhomboid; cl11446 889932003546 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 889932003547 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 889932003548 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932003549 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 889932003550 catalytic triad [active] 889932003551 active site nucleophile [active] 889932003552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889932003553 active site residue [active] 889932003554 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 889932003555 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889932003556 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 889932003557 active site 889932003558 catalytic site [active] 889932003559 metal binding site [ion binding]; metal-binding site 889932003560 dimer interface [polypeptide binding]; other site 889932003561 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 889932003562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003563 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 889932003564 DNA binding residues [nucleotide binding] 889932003565 putative dimer interface [polypeptide binding]; other site 889932003566 glutamine synthetase, type I; Region: GlnA; TIGR00653 889932003567 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 889932003568 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 889932003569 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 889932003570 dUTPase; Region: dUTPase_2; pfam08761 889932003571 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 889932003572 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 889932003573 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 889932003574 Protein of unknown function (DUF464); Region: DUF464; cl01080 889932003575 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 889932003576 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889932003577 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889932003578 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889932003579 active site 889932003580 elongation factor P; Validated; Region: PRK00529 889932003581 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 889932003582 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 889932003583 RNA binding site [nucleotide binding]; other site 889932003584 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 889932003585 RNA binding site [nucleotide binding]; other site 889932003586 Asp23 family; Region: Asp23; cl00574 889932003587 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 889932003588 putative RNA binding site [nucleotide binding]; other site 889932003589 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 889932003590 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 889932003591 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 889932003592 homodimer interface [polypeptide binding]; other site 889932003593 NADP binding site [chemical binding]; other site 889932003594 substrate binding site [chemical binding]; other site 889932003595 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 889932003596 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 889932003597 generic binding surface II; other site 889932003598 generic binding surface I; other site 889932003599 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 889932003600 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 889932003601 substrate binding pocket [chemical binding]; other site 889932003602 chain length determination region; other site 889932003603 substrate-Mg2+ binding site; other site 889932003604 catalytic residues [active] 889932003605 aspartate-rich region 1; other site 889932003606 active site lid residues [active] 889932003607 aspartate-rich region 2; other site 889932003608 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 889932003609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889932003610 RNA binding surface [nucleotide binding]; other site 889932003611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 889932003612 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 889932003613 arginine repressor; Provisional; Region: PRK04280 889932003614 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 889932003615 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 889932003616 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 889932003617 Walker A/P-loop; other site 889932003618 ATP binding site [chemical binding]; other site 889932003619 Q-loop/lid; other site 889932003620 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 889932003621 ABC transporter signature motif; other site 889932003622 Walker B; other site 889932003623 D-loop; other site 889932003624 H-loop/switch region; other site 889932003625 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 889932003626 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 889932003627 Walker A/P-loop; other site 889932003628 ATP binding site [chemical binding]; other site 889932003629 Q-loop/lid; other site 889932003630 ABC transporter signature motif; other site 889932003631 Walker B; other site 889932003632 D-loop; other site 889932003633 H-loop/switch region; other site 889932003634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 889932003635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932003636 dimer interface [polypeptide binding]; other site 889932003637 conserved gate region; other site 889932003638 putative PBP binding loops; other site 889932003639 ABC-ATPase subunit interface; other site 889932003640 NMT1-like family; Region: NMT1_2; cl15260 889932003641 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 889932003642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932003643 dimer interface [polypeptide binding]; other site 889932003644 conserved gate region; other site 889932003645 putative PBP binding loops; other site 889932003646 ABC-ATPase subunit interface; other site 889932003647 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 889932003648 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 889932003649 catalytic site [active] 889932003650 G-X2-G-X-G-K; other site 889932003651 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 889932003652 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 889932003653 Flavoprotein; Region: Flavoprotein; cl08021 889932003654 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 889932003655 primosome assembly protein PriA; Validated; Region: PRK05580 889932003656 primosome assembly protein PriA; Validated; Region: PRK05580 889932003657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932003658 ATP binding site [chemical binding]; other site 889932003659 putative Mg++ binding site [ion binding]; other site 889932003660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932003661 nucleotide binding region [chemical binding]; other site 889932003662 ATP-binding site [chemical binding]; other site 889932003663 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 889932003664 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 889932003665 putative active site [active] 889932003666 substrate binding site [chemical binding]; other site 889932003667 putative cosubstrate binding site; other site 889932003668 catalytic site [active] 889932003669 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 889932003670 substrate binding site [chemical binding]; other site 889932003671 16S rRNA methyltransferase B; Provisional; Region: PRK14902 889932003672 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 889932003673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932003674 S-adenosylmethionine binding site [chemical binding]; other site 889932003675 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 889932003676 active site 889932003677 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 889932003678 Catalytic domain of Protein Kinases; Region: PKc; cd00180 889932003679 active site 889932003680 ATP binding site [chemical binding]; other site 889932003681 substrate binding site [chemical binding]; other site 889932003682 activation loop (A-loop); other site 889932003683 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889932003684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 889932003685 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889932003686 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889932003687 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 889932003688 GTPase RsgA; Reviewed; Region: PRK00098 889932003689 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 889932003690 RNA binding site [nucleotide binding]; other site 889932003691 homodimer interface [polypeptide binding]; other site 889932003692 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 889932003693 GTPase/Zn-binding domain interface [polypeptide binding]; other site 889932003694 GTP/Mg2+ binding site [chemical binding]; other site 889932003695 G4 box; other site 889932003696 G5 box; other site 889932003697 G1 box; other site 889932003698 Switch I region; other site 889932003699 G2 box; other site 889932003700 G3 box; other site 889932003701 Switch II region; other site 889932003702 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 889932003703 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 889932003704 substrate binding site [chemical binding]; other site 889932003705 hexamer interface [polypeptide binding]; other site 889932003706 metal binding site [ion binding]; metal-binding site 889932003707 Thiamine pyrophosphokinase; Region: TPK; cd07995 889932003708 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 889932003709 active site 889932003710 dimerization interface [polypeptide binding]; other site 889932003711 thiamine binding site [chemical binding]; other site 889932003712 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 889932003713 Asp23 family; Region: Asp23; cl00574 889932003714 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 889932003715 DAK2 domain; Region: Dak2; cl03685 889932003716 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932003717 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 889932003718 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 889932003719 generic binding surface II; other site 889932003720 ssDNA binding site; other site 889932003721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932003722 ATP binding site [chemical binding]; other site 889932003723 putative Mg++ binding site [ion binding]; other site 889932003724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932003725 nucleotide binding region [chemical binding]; other site 889932003726 ATP-binding site [chemical binding]; other site 889932003727 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 889932003728 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889932003729 ribonuclease III; Reviewed; Region: rnc; PRK00102 889932003730 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 889932003731 dimerization interface [polypeptide binding]; other site 889932003732 active site 889932003733 metal binding site [ion binding]; metal-binding site 889932003734 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 889932003735 dsRNA binding site [nucleotide binding]; other site 889932003736 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 889932003737 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 889932003738 Walker A/P-loop; other site 889932003739 ATP binding site [chemical binding]; other site 889932003740 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 889932003741 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 889932003742 ABC transporter signature motif; other site 889932003743 Walker B; other site 889932003744 D-loop; other site 889932003745 H-loop/switch region; other site 889932003746 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 889932003747 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 889932003748 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 889932003749 P loop; other site 889932003750 GTP binding site [chemical binding]; other site 889932003751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932003752 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 889932003753 signal recognition particle protein; Provisional; Region: PRK10867 889932003754 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 889932003755 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 889932003756 P loop; other site 889932003757 GTP binding site [chemical binding]; other site 889932003758 Signal peptide binding domain; Region: SRP_SPB; pfam02978 889932003759 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 889932003760 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 889932003761 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 889932003762 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 889932003763 RimM N-terminal domain; Region: RimM; pfam01782 889932003764 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 889932003765 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 889932003766 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 889932003767 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932003768 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932003769 MucBP domain; Region: MucBP; pfam06458 889932003770 MucBP domain; Region: MucBP; pfam06458 889932003771 MucBP domain; Region: MucBP; pfam06458 889932003772 MucBP domain; Region: MucBP; pfam06458 889932003773 MucBP domain; Region: MucBP; pfam06458 889932003774 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 889932003775 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 889932003776 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932003777 Walker A/P-loop; other site 889932003778 ATP binding site [chemical binding]; other site 889932003779 Q-loop/lid; other site 889932003780 ABC transporter signature motif; other site 889932003781 Walker B; other site 889932003782 D-loop; other site 889932003783 H-loop/switch region; other site 889932003784 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 889932003785 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 889932003786 chorismate binding enzyme; Region: Chorismate_bind; cl10555 889932003787 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 889932003788 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 889932003789 glutamine binding [chemical binding]; other site 889932003790 catalytic triad [active] 889932003791 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 889932003792 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 889932003793 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 889932003794 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 889932003795 active site 889932003796 ribulose/triose binding site [chemical binding]; other site 889932003797 phosphate binding site [ion binding]; other site 889932003798 substrate (anthranilate) binding pocket [chemical binding]; other site 889932003799 product (indole) binding pocket [chemical binding]; other site 889932003800 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 889932003801 active site 889932003802 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 889932003803 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 889932003804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932003805 catalytic residue [active] 889932003806 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 889932003807 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 889932003808 substrate binding site [chemical binding]; other site 889932003809 active site 889932003810 catalytic residues [active] 889932003811 heterodimer interface [polypeptide binding]; other site 889932003812 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 889932003813 catalytic triad [active] 889932003814 conserved cis-peptide bond; other site 889932003815 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932003816 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 889932003817 NADP binding site [chemical binding]; other site 889932003818 dimer interface [polypeptide binding]; other site 889932003819 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932003820 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 889932003821 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 889932003822 metal binding site [ion binding]; metal-binding site 889932003823 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 889932003824 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889932003825 catalytic Zn binding site [ion binding]; other site 889932003826 NAD(P) binding site [chemical binding]; other site 889932003827 structural Zn binding site [ion binding]; other site 889932003828 short chain dehydrogenase; Validated; Region: PRK06182 889932003829 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 889932003830 NADP binding site [chemical binding]; other site 889932003831 active site 889932003832 steroid binding site; other site 889932003833 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 889932003834 Helix-turn-helix domains; Region: HTH; cl00088 889932003835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889932003836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932003837 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 889932003838 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 889932003839 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 889932003840 dimer interface [polypeptide binding]; other site 889932003841 active site 889932003842 CoA binding pocket [chemical binding]; other site 889932003843 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889932003844 Acyl transferase domain; Region: Acyl_transf_1; cl08282 889932003845 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 889932003846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932003847 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 889932003848 NAD(P) binding site [chemical binding]; other site 889932003849 active site 889932003850 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 889932003851 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 889932003852 dimer interface [polypeptide binding]; other site 889932003853 active site 889932003854 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 889932003855 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889932003856 carboxyltransferase (CT) interaction site; other site 889932003857 biotinylation site [posttranslational modification]; other site 889932003858 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 889932003859 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 889932003860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932003861 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932003862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 889932003863 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 889932003864 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889932003865 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 889932003866 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 889932003867 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 889932003868 NAD binding site [chemical binding]; other site 889932003869 homotetramer interface [polypeptide binding]; other site 889932003870 homodimer interface [polypeptide binding]; other site 889932003871 substrate binding site [chemical binding]; other site 889932003872 active site 889932003873 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 889932003874 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 889932003875 Protein of unknown function (DUF554); Region: DUF554; cl00784 889932003876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932003877 Helix-turn-helix domains; Region: HTH; cl00088 889932003878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932003879 dimerization interface [polypeptide binding]; other site 889932003880 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 889932003881 GTPase RsgA; Reviewed; Region: PRK01889 889932003882 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889932003883 RNA binding site [nucleotide binding]; other site 889932003884 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 889932003885 GTPase/Zn-binding domain interface [polypeptide binding]; other site 889932003886 GTP/Mg2+ binding site [chemical binding]; other site 889932003887 G4 box; other site 889932003888 G5 box; other site 889932003889 G1 box; other site 889932003890 Switch I region; other site 889932003891 G2 box; other site 889932003892 G3 box; other site 889932003893 Switch II region; other site 889932003894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932003895 Helix-turn-helix domains; Region: HTH; cl00088 889932003896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932003897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932003898 putative substrate translocation pore; other site 889932003899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932003900 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 889932003901 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932003902 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 889932003903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932003904 S-adenosylmethionine binding site [chemical binding]; other site 889932003905 Chitin binding domain; Region: Chitin_bind_3; cl03871 889932003906 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 889932003907 TspO/MBR family; Region: TspO_MBR; cl01379 889932003908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932003909 Ligand Binding Site [chemical binding]; other site 889932003910 Protein of unknown function (DUF805); Region: DUF805; cl01224 889932003911 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 889932003912 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889932003913 CsbD-like; Region: CsbD; cl15799 889932003914 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 889932003915 Peptidase family C69; Region: Peptidase_C69; pfam03577 889932003916 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 889932003917 active site 1 [active] 889932003918 dimer interface [polypeptide binding]; other site 889932003919 hexamer interface [polypeptide binding]; other site 889932003920 active site 2 [active] 889932003921 diaminopimelate decarboxylase; Region: lysA; TIGR01048 889932003922 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 889932003923 active site 889932003924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 889932003925 substrate binding site [chemical binding]; other site 889932003926 catalytic residues [active] 889932003927 dimer interface [polypeptide binding]; other site 889932003928 UbiA prenyltransferase family; Region: UbiA; cl00337 889932003929 Voltage-dependent potassium channel; Provisional; Region: PLN03192 889932003930 Ion channel; Region: Ion_trans_2; cl11596 889932003931 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 889932003932 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 889932003933 inhibitor-cofactor binding pocket; inhibition site 889932003934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932003935 catalytic residue [active] 889932003936 amino acid transporter; Region: 2A0306; TIGR00909 889932003937 Spore germination protein; Region: Spore_permease; cl15802 889932003938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932003939 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932003940 active site 889932003941 motif I; other site 889932003942 motif II; other site 889932003943 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932003944 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 889932003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932003946 S-adenosylmethionine binding site [chemical binding]; other site 889932003947 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 889932003948 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 889932003949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932003950 putative substrate translocation pore; other site 889932003951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932003952 maltose phosphorylase; Provisional; Region: PRK13807 889932003953 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 889932003954 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 889932003955 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 889932003956 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 889932003957 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 889932003958 active site 889932003959 catalytic residues [active] 889932003960 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 889932003961 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 889932003962 homotetramer interface [polypeptide binding]; other site 889932003963 FMN binding site [chemical binding]; other site 889932003964 homodimer contacts [polypeptide binding]; other site 889932003965 putative active site [active] 889932003966 putative substrate binding site [chemical binding]; other site 889932003967 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 889932003968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889932003969 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 889932003970 mevalonate kinase; Region: mevalon_kin; TIGR00549 889932003971 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889932003972 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889932003973 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 889932003974 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889932003975 active site 889932003976 catalytic site [active] 889932003977 substrate binding site [chemical binding]; other site 889932003978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003979 ATP binding site [chemical binding]; other site 889932003980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932003981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 889932003982 aspartate aminotransferase; Provisional; Region: PRK05764 889932003983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932003984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932003985 homodimer interface [polypeptide binding]; other site 889932003986 catalytic residue [active] 889932003987 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 889932003988 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 889932003989 Dimer interface [polypeptide binding]; other site 889932003990 anticodon binding site; other site 889932003991 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 889932003992 homodimer interface [polypeptide binding]; other site 889932003993 motif 1; other site 889932003994 motif 2; other site 889932003995 active site 889932003996 motif 3; other site 889932003997 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 889932003998 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 889932003999 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 889932004000 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 889932004001 Walker A/P-loop; other site 889932004002 ATP binding site [chemical binding]; other site 889932004003 Q-loop/lid; other site 889932004004 ABC transporter signature motif; other site 889932004005 Walker B; other site 889932004006 D-loop; other site 889932004007 H-loop/switch region; other site 889932004008 NIL domain; Region: NIL; cl09633 889932004009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889932004010 NMT1-like family; Region: NMT1_2; cl15260 889932004011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932004012 Ligand Binding Site [chemical binding]; other site 889932004013 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 889932004014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932004015 dimer interface [polypeptide binding]; other site 889932004016 conserved gate region; other site 889932004017 putative PBP binding loops; other site 889932004018 ABC-ATPase subunit interface; other site 889932004019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932004020 dimer interface [polypeptide binding]; other site 889932004021 conserved gate region; other site 889932004022 putative PBP binding loops; other site 889932004023 ABC-ATPase subunit interface; other site 889932004024 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 889932004025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932004026 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 889932004027 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 889932004028 Walker A/P-loop; other site 889932004029 ATP binding site [chemical binding]; other site 889932004030 Q-loop/lid; other site 889932004031 ABC transporter signature motif; other site 889932004032 Walker B; other site 889932004033 D-loop; other site 889932004034 H-loop/switch region; other site 889932004035 Transglycosylase; Region: Transgly; cl07896 889932004036 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 889932004037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932004038 Recombination protein U; Region: RecU; cl01314 889932004039 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 889932004040 cell division protein GpsB; Provisional; Region: PRK14127 889932004041 DivIVA domain; Region: DivI1A_domain; TIGR03544 889932004042 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 889932004043 THUMP domain; Region: THUMP; cl12076 889932004044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004045 esterase; Provisional; Region: PRK10566 889932004046 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932004047 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 889932004048 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 889932004049 putative dimer interface [polypeptide binding]; other site 889932004050 catalytic triad [active] 889932004051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932004052 Coenzyme A binding pocket [chemical binding]; other site 889932004053 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889932004054 active site 889932004055 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 889932004056 putative dimer interface [polypeptide binding]; other site 889932004057 catalytic triad [active] 889932004058 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 889932004059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004060 Walker A/P-loop; other site 889932004061 ATP binding site [chemical binding]; other site 889932004062 Q-loop/lid; other site 889932004063 ABC transporter signature motif; other site 889932004064 Walker B; other site 889932004065 D-loop; other site 889932004066 H-loop/switch region; other site 889932004067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889932004068 FAD dependent oxidoreductase; Region: DAO; pfam01266 889932004069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004070 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 889932004071 RNA/DNA hybrid binding site [nucleotide binding]; other site 889932004072 active site 889932004073 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 889932004074 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 889932004075 Potassium binding sites [ion binding]; other site 889932004076 Cesium cation binding sites [ion binding]; other site 889932004077 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 889932004078 lipoprotein signal peptidase; Provisional; Region: PRK14787 889932004079 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 889932004080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889932004081 RNA binding surface [nucleotide binding]; other site 889932004082 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 889932004083 active site 889932004084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932004085 active site 889932004086 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 889932004087 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 889932004088 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 889932004089 catalytic site [active] 889932004090 subunit interface [polypeptide binding]; other site 889932004091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932004092 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 889932004093 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932004094 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 889932004095 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 889932004096 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 889932004097 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 889932004098 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932004099 catalytic core [active] 889932004100 Protein of unknown function (DUF419); Region: DUF419; cl15265 889932004101 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 889932004102 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 889932004103 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 889932004104 GIY-YIG motif/motif A; other site 889932004105 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 889932004106 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 889932004107 nudix motif; other site 889932004108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932004109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004110 Walker A/P-loop; other site 889932004111 ATP binding site [chemical binding]; other site 889932004112 Q-loop/lid; other site 889932004113 ABC transporter signature motif; other site 889932004114 Walker B; other site 889932004115 D-loop; other site 889932004116 H-loop/switch region; other site 889932004117 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932004118 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 889932004119 Domain of unknown function (DUF814); Region: DUF814; pfam05670 889932004120 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004121 Helix-turn-helix domains; Region: HTH; cl00088 889932004122 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932004123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932004124 Coenzyme A binding pocket [chemical binding]; other site 889932004125 Protein of unknown function (DUF975); Region: DUF975; cl10504 889932004126 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 889932004127 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889932004128 nucleotide binding site/active site [active] 889932004129 HIT family signature motif; other site 889932004130 catalytic residue [active] 889932004131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932004132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932004133 putative substrate translocation pore; other site 889932004134 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 889932004135 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 889932004136 Domain of unknown function (DUF368); Region: DUF368; cl00893 889932004137 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889932004138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932004139 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932004140 L-lactate permease; Region: Lactate_perm; cl00701 889932004141 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 889932004142 substrate binding site; other site 889932004143 dimer interface; other site 889932004144 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 889932004145 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889932004146 putative NAD(P) binding site [chemical binding]; other site 889932004147 putative catalytic Zn binding site [ion binding]; other site 889932004148 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889932004149 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889932004150 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889932004151 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889932004152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932004153 Coenzyme A binding pocket [chemical binding]; other site 889932004154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004155 Helix-turn-helix domains; Region: HTH; cl00088 889932004156 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 889932004157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932004158 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932004159 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 889932004160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889932004161 active site 889932004162 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 889932004163 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 889932004164 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 889932004165 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 889932004166 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 889932004167 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 889932004168 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 889932004169 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 889932004170 DHHA2 domain; Region: DHHA2; pfam02833 889932004171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932004172 Helix-turn-helix domains; Region: HTH; cl00088 889932004173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932004174 dimerization interface [polypeptide binding]; other site 889932004175 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 889932004176 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 889932004177 CAP-like domain; other site 889932004178 active site 889932004179 primary dimer interface [polypeptide binding]; other site 889932004180 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932004181 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 889932004182 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 889932004183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932004184 ATP binding site [chemical binding]; other site 889932004185 Mg2+ binding site [ion binding]; other site 889932004186 G-X-G motif; other site 889932004187 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 889932004188 anchoring element; other site 889932004189 dimer interface [polypeptide binding]; other site 889932004190 ATP binding site [chemical binding]; other site 889932004191 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 889932004192 active site 889932004193 putative metal-binding site [ion binding]; other site 889932004194 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 889932004195 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 889932004196 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 889932004197 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 889932004198 active site 889932004199 catalytic residues [active] 889932004200 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 889932004201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932004202 Walker A motif; other site 889932004203 ATP binding site [chemical binding]; other site 889932004204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004205 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932004206 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 889932004207 active site 889932004208 HslU subunit interaction site [polypeptide binding]; other site 889932004209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889932004210 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 889932004211 active site 889932004212 DNA binding site [nucleotide binding] 889932004213 Int/Topo IB signature motif; other site 889932004214 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 889932004215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004216 DNA topoisomerase I; Validated; Region: PRK05582 889932004217 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 889932004218 active site 889932004219 interdomain interaction site; other site 889932004220 putative metal-binding site [ion binding]; other site 889932004221 nucleotide binding site [chemical binding]; other site 889932004222 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 889932004223 domain I; other site 889932004224 DNA binding groove [nucleotide binding] 889932004225 phosphate binding site [ion binding]; other site 889932004226 domain II; other site 889932004227 domain III; other site 889932004228 nucleotide binding site [chemical binding]; other site 889932004229 catalytic site [active] 889932004230 domain IV; other site 889932004231 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 889932004232 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 889932004233 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 889932004234 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 889932004235 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 889932004236 RNA/DNA hybrid binding site [nucleotide binding]; other site 889932004237 active site 889932004238 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 889932004239 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 889932004240 GTP/Mg2+ binding site [chemical binding]; other site 889932004241 G4 box; other site 889932004242 G5 box; other site 889932004243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004244 G1 box; other site 889932004245 G1 box; other site 889932004246 GTP/Mg2+ binding site [chemical binding]; other site 889932004247 Switch I region; other site 889932004248 G2 box; other site 889932004249 G2 box; other site 889932004250 G3 box; other site 889932004251 G3 box; other site 889932004252 Switch II region; other site 889932004253 Switch II region; other site 889932004254 G4 box; other site 889932004255 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 889932004256 substrate binding site [chemical binding]; other site 889932004257 THF binding site; other site 889932004258 zinc-binding site [ion binding]; other site 889932004259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932004260 Helix-turn-helix domains; Region: HTH; cl00088 889932004261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932004262 dimerization interface [polypeptide binding]; other site 889932004263 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 889932004264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004265 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 889932004266 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 889932004267 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932004268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932004269 putative substrate translocation pore; other site 889932004270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932004271 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932004272 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 889932004273 C-terminal peptidase (prc); Region: prc; TIGR00225 889932004274 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 889932004275 protein binding site [polypeptide binding]; other site 889932004276 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 889932004277 Catalytic dyad [active] 889932004278 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 889932004279 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 889932004280 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 889932004281 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 889932004282 active site 889932004283 catalytic triad [active] 889932004284 oxyanion hole [active] 889932004285 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932004286 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 889932004287 folate binding site [chemical binding]; other site 889932004288 NADP+ binding site [chemical binding]; other site 889932004289 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 889932004290 dimerization interface [polypeptide binding]; other site 889932004291 active site 889932004292 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889932004293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004294 Walker A/P-loop; other site 889932004295 ATP binding site [chemical binding]; other site 889932004296 Q-loop/lid; other site 889932004297 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932004298 ABC transporter signature motif; other site 889932004299 Walker B; other site 889932004300 D-loop; other site 889932004301 ABC transporter; Region: ABC_tran_2; pfam12848 889932004302 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932004303 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 889932004304 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 889932004305 active site 889932004306 NTP binding site [chemical binding]; other site 889932004307 metal binding triad [ion binding]; metal-binding site 889932004308 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 889932004309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932004310 dihydrodipicolinate reductase; Provisional; Region: PRK00048 889932004311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004312 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 889932004313 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932004314 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932004315 active site 889932004316 motif I; other site 889932004317 motif II; other site 889932004318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932004319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889932004320 binding surface 889932004321 TPR motif; other site 889932004322 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 889932004323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889932004324 binding surface 889932004325 TPR motif; other site 889932004326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 889932004327 binding surface 889932004328 TPR motif; other site 889932004329 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 889932004330 IHF dimer interface [polypeptide binding]; other site 889932004331 IHF - DNA interface [nucleotide binding]; other site 889932004332 GTP-binding protein Der; Reviewed; Region: PRK00093 889932004333 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 889932004334 G1 box; other site 889932004335 GTP/Mg2+ binding site [chemical binding]; other site 889932004336 Switch I region; other site 889932004337 G2 box; other site 889932004338 Switch II region; other site 889932004339 G3 box; other site 889932004340 G4 box; other site 889932004341 G5 box; other site 889932004342 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 889932004343 G1 box; other site 889932004344 GTP/Mg2+ binding site [chemical binding]; other site 889932004345 Switch I region; other site 889932004346 G2 box; other site 889932004347 G3 box; other site 889932004348 Switch II region; other site 889932004349 G4 box; other site 889932004350 G5 box; other site 889932004351 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 889932004352 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 889932004353 RNA binding site [nucleotide binding]; other site 889932004354 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 889932004355 RNA binding site [nucleotide binding]; other site 889932004356 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 889932004357 RNA binding site [nucleotide binding]; other site 889932004358 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 889932004359 RNA binding site [nucleotide binding]; other site 889932004360 cytidylate kinase; Provisional; Region: cmk; PRK00023 889932004361 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 889932004362 CMP-binding site; other site 889932004363 The sites determining sugar specificity; other site 889932004364 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932004365 putative peptidoglycan binding site; other site 889932004366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 889932004367 ATP binding site [chemical binding]; other site 889932004368 putative Mg++ binding site [ion binding]; other site 889932004369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932004370 nucleotide binding region [chemical binding]; other site 889932004371 ATP-binding site [chemical binding]; other site 889932004372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 889932004373 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889932004374 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 889932004375 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 889932004376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889932004377 RNA binding surface [nucleotide binding]; other site 889932004378 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 889932004379 active site 889932004380 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 889932004381 ScpA/B protein; Region: ScpA_ScpB; cl00598 889932004382 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 889932004383 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 889932004384 active site 889932004385 Int/Topo IB signature motif; other site 889932004386 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 889932004387 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 889932004388 Protein of unknown function (DUF441); Region: DUF441; cl01041 889932004389 pyruvate kinase; Provisional; Region: PRK06354 889932004390 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889932004391 domain interfaces; other site 889932004392 active site 889932004393 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 889932004394 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 889932004395 active site 889932004396 ADP/pyrophosphate binding site [chemical binding]; other site 889932004397 dimerization interface [polypeptide binding]; other site 889932004398 allosteric effector site; other site 889932004399 fructose-1,6-bisphosphate binding site; other site 889932004400 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 889932004401 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 889932004402 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 889932004403 generic binding surface I; other site 889932004404 generic binding surface II; other site 889932004405 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 889932004406 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 889932004407 Clp amino terminal domain; Region: Clp_N; pfam02861 889932004408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932004409 Walker A motif; other site 889932004410 ATP binding site [chemical binding]; other site 889932004411 Walker B motif; other site 889932004412 arginine finger; other site 889932004413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932004414 Walker A motif; other site 889932004415 ATP binding site [chemical binding]; other site 889932004416 Walker B motif; other site 889932004417 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932004418 peptidase T; Region: peptidase-T; TIGR01882 889932004419 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 889932004420 metal binding site [ion binding]; metal-binding site 889932004421 dimer interface [polypeptide binding]; other site 889932004422 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 889932004423 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 889932004424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004425 O-Antigen ligase; Region: Wzy_C; cl04850 889932004426 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932004427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004428 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 889932004429 Walker A/P-loop; other site 889932004430 ATP binding site [chemical binding]; other site 889932004431 Q-loop/lid; other site 889932004432 ABC transporter signature motif; other site 889932004433 Walker B; other site 889932004434 D-loop; other site 889932004435 H-loop/switch region; other site 889932004436 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004437 Helix-turn-helix domains; Region: HTH; cl00088 889932004438 phosphoenolpyruvate synthase; Validated; Region: PRK06464 889932004439 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 889932004440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 889932004441 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 889932004442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 889932004443 active site residue [active] 889932004444 Helix-turn-helix domains; Region: HTH; cl00088 889932004445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004446 Acyltransferase family; Region: Acyl_transf_3; pfam01757 889932004447 OpgC protein; Region: OpgC_C; cl00792 889932004448 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 889932004449 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932004450 putative NAD(P) binding site [chemical binding]; other site 889932004451 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 889932004452 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 889932004453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932004454 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932004455 enolase; Provisional; Region: eno; PRK00077 889932004456 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 889932004457 dimer interface [polypeptide binding]; other site 889932004458 metal binding site [ion binding]; metal-binding site 889932004459 substrate binding pocket [chemical binding]; other site 889932004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932004461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932004462 putative substrate translocation pore; other site 889932004463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932004464 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004465 Helix-turn-helix domains; Region: HTH; cl00088 889932004466 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 889932004467 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 889932004468 metal binding site [ion binding]; metal-binding site 889932004469 dimer interface [polypeptide binding]; other site 889932004470 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 889932004471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932004472 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932004473 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 889932004474 active site residue [active] 889932004475 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889932004476 Helix-turn-helix domains; Region: HTH; cl00088 889932004477 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889932004478 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 889932004479 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 889932004480 nudix motif; other site 889932004481 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889932004482 ArsC family; Region: ArsC; pfam03960 889932004483 putative catalytic residues [active] 889932004484 thiol/disulfide switch; other site 889932004485 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 889932004486 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 889932004487 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932004488 putative NAD(P) binding site [chemical binding]; other site 889932004489 Uncharacterized conserved protein [Function unknown]; Region: COG4715 889932004490 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889932004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932004492 motif II; other site 889932004493 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932004494 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932004495 active site 889932004496 substrate binding site [chemical binding]; other site 889932004497 trimer interface [polypeptide binding]; other site 889932004498 CoA binding site [chemical binding]; other site 889932004499 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932004500 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932004501 putative active site [active] 889932004502 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932004503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004504 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932004505 NAD(P) binding site [chemical binding]; other site 889932004506 active site 889932004507 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 889932004508 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 889932004509 Helix-turn-helix domains; Region: HTH; cl00088 889932004510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932004511 dimerization interface [polypeptide binding]; other site 889932004512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932004513 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 889932004514 putative NAD(P) binding site [chemical binding]; other site 889932004515 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932004516 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932004517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932004518 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932004519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 889932004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932004521 active site 889932004522 phosphorylation site [posttranslational modification] 889932004523 intermolecular recognition site; other site 889932004524 dimerization interface [polypeptide binding]; other site 889932004525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 889932004526 DNA binding residues [nucleotide binding] 889932004527 dimerization interface [polypeptide binding]; other site 889932004528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 889932004529 Histidine kinase; Region: HisKA_3; pfam07730 889932004530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889932004531 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932004532 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932004533 Walker A/P-loop; other site 889932004534 ATP binding site [chemical binding]; other site 889932004535 Q-loop/lid; other site 889932004536 ABC transporter signature motif; other site 889932004537 Walker B; other site 889932004538 D-loop; other site 889932004539 H-loop/switch region; other site 889932004540 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932004541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 889932004542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932004543 Helix-turn-helix domains; Region: HTH; cl00088 889932004544 Predicted membrane protein [Function unknown]; Region: COG2364 889932004545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004546 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 889932004547 Walker A/P-loop; other site 889932004548 ATP binding site [chemical binding]; other site 889932004549 Q-loop/lid; other site 889932004550 ABC transporter signature motif; other site 889932004551 Walker B; other site 889932004552 D-loop; other site 889932004553 H-loop/switch region; other site 889932004554 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932004555 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932004556 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932004557 Walker A/P-loop; other site 889932004558 ATP binding site [chemical binding]; other site 889932004559 Q-loop/lid; other site 889932004560 ABC transporter signature motif; other site 889932004561 Walker B; other site 889932004562 D-loop; other site 889932004563 H-loop/switch region; other site 889932004564 Predicted transcriptional regulators [Transcription]; Region: COG1725 889932004565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932004566 DNA-binding site [nucleotide binding]; DNA binding site 889932004567 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 889932004568 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 889932004569 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 889932004570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 889932004571 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 889932004572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 889932004573 DNA binding residues [nucleotide binding] 889932004574 DNA primase; Validated; Region: dnaG; PRK05667 889932004575 CHC2 zinc finger; Region: zf-CHC2; cl15369 889932004576 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 889932004577 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 889932004578 active site 889932004579 metal binding site [ion binding]; metal-binding site 889932004580 interdomain interaction site; other site 889932004581 PE-PPE domain; Region: PE-PPE; pfam08237 889932004582 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 889932004583 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 889932004584 dimer interface [polypeptide binding]; other site 889932004585 motif 1; other site 889932004586 active site 889932004587 motif 2; other site 889932004588 motif 3; other site 889932004589 DNA repair protein RecO; Region: reco; TIGR00613 889932004590 Recombination protein O N terminal; Region: RecO_N; cl15812 889932004591 Recombination protein O C terminal; Region: RecO_C; pfam02565 889932004592 GTPase Era; Reviewed; Region: era; PRK00089 889932004593 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 889932004594 G1 box; other site 889932004595 GTP/Mg2+ binding site [chemical binding]; other site 889932004596 Switch I region; other site 889932004597 G2 box; other site 889932004598 Switch II region; other site 889932004599 G3 box; other site 889932004600 G4 box; other site 889932004601 G5 box; other site 889932004602 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 889932004603 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 889932004604 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 889932004605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004606 GatB domain; Region: GatB_Yqey; cl11497 889932004607 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 889932004608 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 889932004609 short chain dehydrogenase; Provisional; Region: PRK07041 889932004610 classical (c) SDRs; Region: SDR_c; cd05233 889932004611 NAD(P) binding site [chemical binding]; other site 889932004612 active site 889932004613 endonuclease IV; Provisional; Region: PRK01060 889932004614 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 889932004615 AP (apurinic/apyrimidinic) site pocket; other site 889932004616 DNA interaction; other site 889932004617 Metal-binding active site; metal-binding site 889932004618 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 889932004619 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 889932004620 Uncharacterized conserved protein [Function unknown]; Region: COG1284 889932004621 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 889932004622 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 889932004623 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 889932004624 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 889932004625 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 889932004626 dimer interface [polypeptide binding]; other site 889932004627 anticodon binding site; other site 889932004628 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 889932004629 homodimer interface [polypeptide binding]; other site 889932004630 motif 1; other site 889932004631 active site 889932004632 motif 2; other site 889932004633 GAD domain; Region: GAD; pfam02938 889932004634 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889932004635 active site 889932004636 motif 3; other site 889932004637 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 889932004638 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 889932004639 dimer interface [polypeptide binding]; other site 889932004640 motif 1; other site 889932004641 active site 889932004642 motif 2; other site 889932004643 motif 3; other site 889932004644 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 889932004645 anticodon binding site; other site 889932004646 Bacterial SH3 domain; Region: SH3_3; cl02551 889932004647 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 889932004648 active site 889932004649 metal binding site [ion binding]; metal-binding site 889932004650 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889932004651 active site 889932004652 ATP binding site [chemical binding]; other site 889932004653 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 889932004654 substrate binding site [chemical binding]; other site 889932004655 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889932004656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932004657 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 889932004658 putative active site [active] 889932004659 dimerization interface [polypeptide binding]; other site 889932004660 putative tRNAtyr binding site [nucleotide binding]; other site 889932004661 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 889932004662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932004663 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889932004664 synthetase active site [active] 889932004665 NTP binding site [chemical binding]; other site 889932004666 metal binding site [ion binding]; metal-binding site 889932004667 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 889932004668 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 889932004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 889932004670 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 889932004671 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 889932004672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004673 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 889932004674 active site 889932004675 DNA binding site [nucleotide binding] 889932004676 GTP-binding protein LepA; Provisional; Region: PRK05433 889932004677 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 889932004678 G1 box; other site 889932004679 putative GEF interaction site [polypeptide binding]; other site 889932004680 GTP/Mg2+ binding site [chemical binding]; other site 889932004681 Switch I region; other site 889932004682 G2 box; other site 889932004683 G3 box; other site 889932004684 Switch II region; other site 889932004685 G4 box; other site 889932004686 G5 box; other site 889932004687 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 889932004688 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 889932004689 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 889932004690 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 889932004691 DltD N-terminal region; Region: DltD_N; pfam04915 889932004692 DltD central region; Region: DltD_M; pfam04918 889932004693 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 889932004694 Phosphopantetheine attachment site; Region: PP-binding; cl09936 889932004695 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 889932004696 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 889932004697 AMP-binding enzyme; Region: AMP-binding; cl15778 889932004698 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 889932004699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932004700 chaperone protein DnaJ; Provisional; Region: PRK14276 889932004701 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 889932004702 HSP70 interaction site [polypeptide binding]; other site 889932004703 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 889932004704 substrate binding site [polypeptide binding]; other site 889932004705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 889932004706 Zn binding sites [ion binding]; other site 889932004707 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 889932004708 dimer interface [polypeptide binding]; other site 889932004709 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 889932004710 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 889932004711 dimer interface [polypeptide binding]; other site 889932004712 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 889932004713 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 889932004714 Helix-turn-helix domains; Region: HTH; cl00088 889932004715 HrcA protein C terminal domain; Region: HrcA; pfam01628 889932004716 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 889932004717 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 889932004718 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 889932004719 active site 889932004720 Riboflavin kinase; Region: Flavokinase; cl03312 889932004721 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 889932004722 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 889932004723 RNA binding site [nucleotide binding]; other site 889932004724 active site 889932004725 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 889932004726 Shikimate kinase; Region: SKI; pfam01202 889932004727 ADP binding site [chemical binding]; other site 889932004728 magnesium binding site [ion binding]; other site 889932004729 putative shikimate binding site; other site 889932004730 prephenate dehydrogenase; Validated; Region: PRK06545 889932004731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004732 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 889932004733 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 889932004734 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 889932004735 hinge; other site 889932004736 active site 889932004737 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 889932004738 Tetramer interface [polypeptide binding]; other site 889932004739 active site 889932004740 FMN-binding site [chemical binding]; other site 889932004741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932004742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932004743 putative substrate translocation pore; other site 889932004744 Chorismate mutase type II; Region: CM_2; cl00693 889932004745 Ribosome-binding factor A; Region: RBFA; cl00542 889932004746 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 889932004747 translation initiation factor IF-2; Region: IF-2; TIGR00487 889932004748 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 889932004749 G1 box; other site 889932004750 putative GEF interaction site [polypeptide binding]; other site 889932004751 GTP/Mg2+ binding site [chemical binding]; other site 889932004752 Switch I region; other site 889932004753 G2 box; other site 889932004754 G3 box; other site 889932004755 Switch II region; other site 889932004756 G4 box; other site 889932004757 G5 box; other site 889932004758 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 889932004759 Translation-initiation factor 2; Region: IF-2; pfam11987 889932004760 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 889932004761 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 889932004762 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 889932004763 putative RNA binding cleft [nucleotide binding]; other site 889932004764 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 889932004765 NusA N-terminal domain; Region: NusA_N; pfam08529 889932004766 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 889932004767 RNA binding site [nucleotide binding]; other site 889932004768 homodimer interface [polypeptide binding]; other site 889932004769 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 889932004770 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 889932004771 G-X-X-G motif; other site 889932004772 ribosome maturation protein RimP; Reviewed; Region: PRK00092 889932004773 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 889932004774 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 889932004775 Sm1 motif; other site 889932004776 predicted subunit interaction site [polypeptide binding]; other site 889932004777 RNA binding pocket [nucleotide binding]; other site 889932004778 Sm2 motif; other site 889932004779 DNA polymerase III PolC; Validated; Region: polC; PRK00448 889932004780 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 889932004781 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 889932004782 generic binding surface II; other site 889932004783 generic binding surface I; other site 889932004784 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 889932004785 active site 889932004786 catalytic site [active] 889932004787 substrate binding site [chemical binding]; other site 889932004788 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 889932004789 prolyl-tRNA synthetase; Provisional; Region: PRK09194 889932004790 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 889932004791 dimer interface [polypeptide binding]; other site 889932004792 motif 1; other site 889932004793 active site 889932004794 motif 2; other site 889932004795 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 889932004796 putative deacylase active site [active] 889932004797 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 889932004798 active site 889932004799 motif 3; other site 889932004800 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 889932004801 anticodon binding site; other site 889932004802 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 889932004803 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 889932004804 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 889932004805 protein binding site [polypeptide binding]; other site 889932004806 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 889932004807 putative substrate binding region [chemical binding]; other site 889932004808 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 889932004809 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 889932004810 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 889932004811 catalytic residue [active] 889932004812 putative FPP diphosphate binding site; other site 889932004813 putative FPP binding hydrophobic cleft; other site 889932004814 dimer interface [polypeptide binding]; other site 889932004815 putative IPP diphosphate binding site; other site 889932004816 ribosome recycling factor; Reviewed; Region: frr; PRK00083 889932004817 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 889932004818 hinge region; other site 889932004819 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 889932004820 putative nucleotide binding site [chemical binding]; other site 889932004821 uridine monophosphate binding site [chemical binding]; other site 889932004822 homohexameric interface [polypeptide binding]; other site 889932004823 elongation factor Ts; Provisional; Region: tsf; PRK09377 889932004824 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 889932004825 Elongation factor TS; Region: EF_TS; pfam00889 889932004826 Elongation factor TS; Region: EF_TS; pfam00889 889932004827 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 889932004828 rRNA interaction site [nucleotide binding]; other site 889932004829 S8 interaction site; other site 889932004830 putative laminin-1 binding site; other site 889932004831 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 889932004832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932004833 motif II; other site 889932004834 D-lactate dehydrogenase; Validated; Region: PRK08605 889932004835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932004837 S-adenosylmethionine binding site [chemical binding]; other site 889932004838 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 889932004839 putative acyl-acceptor binding pocket; other site 889932004840 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 889932004841 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 889932004842 LexA repressor; Validated; Region: PRK00215 889932004843 Helix-turn-helix domains; Region: HTH; cl00088 889932004844 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 889932004845 Catalytic site [active] 889932004846 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 889932004847 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 889932004848 dimer interface [polypeptide binding]; other site 889932004849 active site 889932004850 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 889932004851 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 889932004852 Ligand binding site; other site 889932004853 Putative Catalytic site; other site 889932004854 DXD motif; other site 889932004855 Helix-turn-helix domains; Region: HTH; cl00088 889932004856 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 889932004857 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 889932004858 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 889932004859 Walker A/P-loop; other site 889932004860 ATP binding site [chemical binding]; other site 889932004861 Q-loop/lid; other site 889932004862 ABC transporter signature motif; other site 889932004863 Walker B; other site 889932004864 D-loop; other site 889932004865 H-loop/switch region; other site 889932004866 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 889932004867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889932004868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889932004869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932004870 dimer interface [polypeptide binding]; other site 889932004871 conserved gate region; other site 889932004872 ABC-ATPase subunit interface; other site 889932004873 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 889932004874 Bacteriophage holin; Region: Phage_holin_1; cl02344 889932004875 Haemolysin XhlA; Region: XhlA; pfam10779 889932004876 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889932004877 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889932004878 active site 889932004879 Bacterial SH3 domain; Region: SH3_3; cl02551 889932004880 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932004881 putative peptidoglycan binding site; other site 889932004882 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 889932004883 Phage-related protein [Function unknown]; Region: COG4722; cl15832 889932004884 Phage-related tail protein [Function unknown]; Region: COG5283 889932004885 Phage-related tail protein [Function unknown]; Region: COG5283 889932004886 NlpC/P60 family; Region: NLPC_P60; cl11438 889932004887 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932004888 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 889932004889 Phage major tail protein; Region: Phage_tail; pfam04630 889932004890 Protein of unknown function (DUF806); Region: DUF806; pfam05657 889932004891 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 889932004892 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 889932004893 oligomerization interface [polypeptide binding]; other site 889932004894 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 889932004895 Phage capsid family; Region: Phage_capsid; pfam05065 889932004896 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 889932004897 oligomer interface [polypeptide binding]; other site 889932004898 active site residues [active] 889932004899 Phage-related protein [Function unknown]; Region: COG4695; cl01923 889932004900 Phage portal protein; Region: Phage_portal; pfam04860 889932004901 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 889932004902 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 889932004903 Phage Terminase; Region: Terminase_1; pfam03354 889932004904 Phage terminase, small subunit; Region: Terminase_4; cl01525 889932004905 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 889932004906 active site 889932004907 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 889932004908 DNA replication protein DnaC; Validated; Region: PRK07952 889932004909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004910 hypothetical protein; Validated; Region: PRK08116 889932004911 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932004912 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 889932004913 BRO family, N-terminal domain; Region: Bro-N; cl10591 889932004914 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 889932004915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932004916 non-specific DNA binding site [nucleotide binding]; other site 889932004917 salt bridge; other site 889932004918 sequence-specific DNA binding site [nucleotide binding]; other site 889932004919 Domain of unknown function (DUF955); Region: DUF955; cl01076 889932004920 HIRAN domain; Region: HIRAN; cl07418 889932004921 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 889932004922 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 889932004923 Int/Topo IB signature motif; other site 889932004924 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 889932004925 nudix motif; other site 889932004926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004927 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 889932004928 H+ Antiporter protein; Region: 2A0121; TIGR00900 889932004929 Helix-turn-helix domains; Region: HTH; cl00088 889932004930 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 889932004931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932004932 active site 889932004933 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 889932004934 DHH family; Region: DHH; pfam01368 889932004935 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 889932004936 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 889932004937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004938 NAD(P) binding site [chemical binding]; other site 889932004939 active site 889932004940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932004941 GTPase CgtA; Reviewed; Region: obgE; PRK12297 889932004942 GTP1/OBG; Region: GTP1_OBG; pfam01018 889932004943 Obg GTPase; Region: Obg; cd01898 889932004944 G1 box; other site 889932004945 GTP/Mg2+ binding site [chemical binding]; other site 889932004946 Switch I region; other site 889932004947 G2 box; other site 889932004948 G3 box; other site 889932004949 Switch II region; other site 889932004950 G4 box; other site 889932004951 G5 box; other site 889932004952 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 889932004953 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889932004954 Helix-turn-helix domains; Region: HTH; cl00088 889932004955 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889932004956 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 889932004957 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 889932004958 putative substrate binding site [chemical binding]; other site 889932004959 putative ATP binding site [chemical binding]; other site 889932004960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932004961 active site 889932004962 phosphorylation site [posttranslational modification] 889932004963 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889932004964 active site 889932004965 P-loop; other site 889932004966 phosphorylation site [posttranslational modification] 889932004967 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932004968 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 889932004969 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889932004970 active site 889932004971 metal binding site [ion binding]; metal-binding site 889932004972 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 889932004973 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 889932004974 MatE; Region: MatE; cl10513 889932004975 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 889932004976 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 889932004977 active site 889932004978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932004979 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 889932004980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932004981 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 889932004982 putative ADP-binding pocket [chemical binding]; other site 889932004983 Bacterial sugar transferase; Region: Bac_transf; cl00939 889932004984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932004985 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 889932004986 NAD(P) binding site [chemical binding]; other site 889932004987 active site 889932004988 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 889932004989 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 889932004990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932004991 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 889932004992 Chain length determinant protein; Region: Wzz; cl15801 889932004993 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 889932004994 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 889932004995 GIY-YIG motif/motif A; other site 889932004996 active site 889932004997 catalytic site [active] 889932004998 putative DNA binding site [nucleotide binding]; other site 889932004999 metal binding site [ion binding]; metal-binding site 889932005000 UvrB/uvrC motif; Region: UVR; pfam02151 889932005001 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 889932005002 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 889932005003 DNA binding site [nucleotide binding] 889932005004 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889932005005 Walker A/P-loop; other site 889932005006 ATP binding site [chemical binding]; other site 889932005007 ABC transporter; Region: ABC_tran; pfam00005 889932005008 Q-loop/lid; other site 889932005009 ABC transporter signature motif; other site 889932005010 Walker B; other site 889932005011 D-loop; other site 889932005012 H-loop/switch region; other site 889932005013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932005014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932005015 substrate binding pocket [chemical binding]; other site 889932005016 membrane-bound complex binding site; other site 889932005017 hinge residues; other site 889932005018 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889932005019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932005020 dimer interface [polypeptide binding]; other site 889932005021 conserved gate region; other site 889932005022 putative PBP binding loops; other site 889932005023 ABC-ATPase subunit interface; other site 889932005024 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 889932005025 Predicted GTPase [General function prediction only]; Region: COG0218 889932005026 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 889932005027 G1 box; other site 889932005028 GTP/Mg2+ binding site [chemical binding]; other site 889932005029 Switch I region; other site 889932005030 G2 box; other site 889932005031 G3 box; other site 889932005032 Switch II region; other site 889932005033 G4 box; other site 889932005034 G5 box; other site 889932005035 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 889932005036 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 889932005037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932005038 Walker A motif; other site 889932005039 ATP binding site [chemical binding]; other site 889932005040 Walker B motif; other site 889932005041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932005042 trigger factor; Provisional; Region: tig; PRK01490 889932005043 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 889932005044 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 889932005045 elongation factor Tu; Reviewed; Region: PRK00049 889932005046 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 889932005047 G1 box; other site 889932005048 GEF interaction site [polypeptide binding]; other site 889932005049 GTP/Mg2+ binding site [chemical binding]; other site 889932005050 Switch I region; other site 889932005051 G2 box; other site 889932005052 G3 box; other site 889932005053 Switch II region; other site 889932005054 G4 box; other site 889932005055 G5 box; other site 889932005056 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 889932005057 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 889932005058 Antibiotic Binding Site [chemical binding]; other site 889932005059 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 889932005060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932005061 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 889932005062 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 889932005063 dihydrodipicolinate synthase; Region: dapA; TIGR00674 889932005064 dimer interface [polypeptide binding]; other site 889932005065 active site 889932005066 catalytic residue [active] 889932005067 drug efflux system protein MdtG; Provisional; Region: PRK09874 889932005068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932005069 putative substrate translocation pore; other site 889932005070 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 889932005071 16S/18S rRNA binding site [nucleotide binding]; other site 889932005072 S13e-L30e interaction site [polypeptide binding]; other site 889932005073 25S rRNA binding site [nucleotide binding]; other site 889932005074 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 889932005075 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 889932005076 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 889932005077 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 889932005078 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 889932005079 Competence protein; Region: Competence; cl00471 889932005080 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932005081 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 889932005082 catalytic motif [active] 889932005083 Zn binding site [ion binding]; other site 889932005084 SLBB domain; Region: SLBB; pfam10531 889932005085 comEA protein; Region: comE; TIGR01259 889932005086 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 889932005087 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 889932005088 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 889932005089 protein binding site [polypeptide binding]; other site 889932005090 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 889932005091 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 889932005092 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 889932005093 active site 889932005094 (T/H)XGH motif; other site 889932005095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932005096 S-adenosylmethionine binding site [chemical binding]; other site 889932005097 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 889932005098 pyruvate carboxylase; Reviewed; Region: PRK12999 889932005099 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932005100 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932005101 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 889932005102 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 889932005103 active site 889932005104 catalytic residues [active] 889932005105 metal binding site [ion binding]; metal-binding site 889932005106 homodimer binding site [polypeptide binding]; other site 889932005107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 889932005108 carboxyltransferase (CT) interaction site; other site 889932005109 biotinylation site [posttranslational modification]; other site 889932005110 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 889932005111 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 889932005112 putative glycosyltransferase, TIGR03111 family; Region: glyc2_xrt_Gpos1 889932005113 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 889932005114 DXD motif; other site 889932005115 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 889932005116 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 889932005117 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 889932005118 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 889932005119 G1 box; other site 889932005120 putative GEF interaction site [polypeptide binding]; other site 889932005121 GTP/Mg2+ binding site [chemical binding]; other site 889932005122 Switch I region; other site 889932005123 G2 box; other site 889932005124 G3 box; other site 889932005125 Switch II region; other site 889932005126 G4 box; other site 889932005127 G5 box; other site 889932005128 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 889932005129 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 889932005130 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 889932005131 active site 889932005132 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 889932005133 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 889932005134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005135 substrate binding site [chemical binding]; other site 889932005136 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 889932005137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932005139 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932005140 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 889932005141 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 889932005142 E3 interaction surface; other site 889932005143 lipoyl attachment site [posttranslational modification]; other site 889932005144 e3 binding domain; Region: E3_binding; pfam02817 889932005145 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 889932005146 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 889932005147 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 889932005148 alpha subunit interface [polypeptide binding]; other site 889932005149 TPP binding site [chemical binding]; other site 889932005150 heterodimer interface [polypeptide binding]; other site 889932005151 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889932005152 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 889932005153 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 889932005154 TPP-binding site [chemical binding]; other site 889932005155 tetramer interface [polypeptide binding]; other site 889932005156 heterodimer interface [polypeptide binding]; other site 889932005157 phosphorylation loop region [posttranslational modification] 889932005158 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889932005159 active site 889932005160 catalytic residues [active] 889932005161 metal binding site [ion binding]; metal-binding site 889932005162 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 889932005163 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 889932005164 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932005165 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 889932005166 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 889932005167 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889932005168 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932005169 putative peptidoglycan binding site; other site 889932005170 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932005171 putative peptidoglycan binding site; other site 889932005172 NlpC/P60 family; Region: NLPC_P60; cl11438 889932005173 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 889932005174 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 889932005175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932005176 active site 889932005177 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 889932005178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005179 Family description; Region: UvrD_C_2; cl15862 889932005180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 889932005181 binding surface 889932005182 TPR motif; other site 889932005183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932005184 catalytic core [active] 889932005185 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 889932005186 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932005187 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932005188 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932005189 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932005190 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 889932005191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005192 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932005193 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 889932005194 Cation transport protein; Region: TrkH; cl10514 889932005195 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 889932005196 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 889932005197 Putative amino acid metabolism; Region: DUF1831; pfam08866 889932005198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932005199 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 889932005200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932005201 catalytic residue [active] 889932005202 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 889932005203 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 889932005204 dimer interface [polypeptide binding]; other site 889932005205 ADP-ribose binding site [chemical binding]; other site 889932005206 active site 889932005207 nudix motif; other site 889932005208 metal binding site [ion binding]; metal-binding site 889932005209 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 889932005210 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 889932005211 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 889932005212 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 889932005213 LytTr DNA-binding domain; Region: LytTR; cl04498 889932005214 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 889932005215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932005216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005217 Walker A/P-loop; other site 889932005218 ATP binding site [chemical binding]; other site 889932005219 Q-loop/lid; other site 889932005220 ABC transporter signature motif; other site 889932005221 Walker B; other site 889932005222 D-loop; other site 889932005223 H-loop/switch region; other site 889932005224 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 889932005225 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889932005226 active site 889932005227 HIGH motif; other site 889932005228 nucleotide binding site [chemical binding]; other site 889932005229 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 889932005230 active site 889932005231 KMSKS motif; other site 889932005232 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 889932005233 tRNA binding surface [nucleotide binding]; other site 889932005234 anticodon binding site; other site 889932005235 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 889932005236 DivIVA protein; Region: DivIVA; pfam05103 889932005237 DivIVA domain; Region: DivI1A_domain; TIGR03544 889932005238 Plant ATP synthase F0; Region: YMF19; cl07975 889932005239 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 889932005240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889932005241 RNA binding surface [nucleotide binding]; other site 889932005242 YGGT family; Region: YGGT; cl00508 889932005243 Protein of unknown function (DUF552); Region: DUF552; cl00775 889932005244 cell division protein FtsZ; Validated; Region: PRK09330 889932005245 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 889932005246 nucleotide binding site [chemical binding]; other site 889932005247 SulA interaction site; other site 889932005248 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 889932005249 Cell division protein FtsA; Region: FtsA; cl11496 889932005250 Cell division protein FtsA; Region: FtsA; cl11496 889932005251 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 889932005252 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 889932005253 Cell division protein FtsQ; Region: FtsQ; pfam03799 889932005254 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 889932005255 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 889932005256 active site 889932005257 homodimer interface [polypeptide binding]; other site 889932005258 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 889932005259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932005261 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889932005262 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 889932005263 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 889932005264 Mg++ binding site [ion binding]; other site 889932005265 putative catalytic motif [active] 889932005266 putative substrate binding site [chemical binding]; other site 889932005267 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 889932005268 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 889932005269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932005270 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 889932005271 Septum formation initiator; Region: DivIC; cl11433 889932005272 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 889932005273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005274 cell division protein MraZ; Reviewed; Region: PRK00326 889932005275 MraZ protein; Region: MraZ; pfam02381 889932005276 MraZ protein; Region: MraZ; pfam02381 889932005277 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 889932005278 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 889932005279 Transposase domain (DUF772); Region: DUF772; cl15789 889932005280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 889932005281 Transposase domain (DUF772); Region: DUF772; cl15789 889932005282 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 889932005283 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 889932005284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005285 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 889932005286 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 889932005287 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 889932005288 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932005289 NAD binding site [chemical binding]; other site 889932005290 substrate binding site [chemical binding]; other site 889932005291 putative active site [active] 889932005292 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 889932005293 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 889932005294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005295 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 889932005296 Domain of unknown function DUF20; Region: UPF0118; pfam01594 889932005297 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889932005298 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 889932005299 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 889932005300 CutC family; Region: CutC; cl01218 889932005301 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 889932005302 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 889932005303 active site 889932005304 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 889932005305 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 889932005306 synthetase active site [active] 889932005307 NTP binding site [chemical binding]; other site 889932005308 metal binding site [ion binding]; metal-binding site 889932005309 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 889932005310 Thioredoxin; Region: Thioredoxin_5; pfam13743 889932005311 catalytic residues [active] 889932005312 oligoendopeptidase F; Region: pepF; TIGR00181 889932005313 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 889932005314 active site 889932005315 Zn binding site [ion binding]; other site 889932005316 Competence protein CoiA-like family; Region: CoiA; cl11541 889932005317 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 889932005318 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889932005319 ArsC family; Region: ArsC; pfam03960 889932005320 putative catalytic residues [active] 889932005321 thiol/disulfide switch; other site 889932005322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 889932005323 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 889932005324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932005325 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932005326 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 889932005327 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 889932005328 RNA binding site [nucleotide binding]; other site 889932005329 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 889932005330 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 889932005331 active site 889932005332 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889932005333 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 889932005334 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 889932005335 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 889932005336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932005337 active site 889932005338 motif I; other site 889932005339 motif II; other site 889932005340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932005341 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 889932005342 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 889932005343 active site 889932005344 metal binding site [ion binding]; metal-binding site 889932005345 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889932005346 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 889932005347 putative active site [active] 889932005348 putative metal binding site [ion binding]; other site 889932005349 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889932005350 Acetokinase family; Region: Acetate_kinase; cl01029 889932005351 propionate/acetate kinase; Provisional; Region: PRK12379 889932005352 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 889932005353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005354 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 889932005355 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 889932005356 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 889932005357 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 889932005358 Type II/IV secretion system protein; Region: T2SE; pfam00437 889932005359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005360 Walker A motif; other site 889932005361 ATP binding site [chemical binding]; other site 889932005362 Walker B motif; other site 889932005363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889932005364 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 889932005365 substrate binding site [chemical binding]; other site 889932005366 dimer interface [polypeptide binding]; other site 889932005367 ATP binding site [chemical binding]; other site 889932005368 Transcriptional regulator; Region: Transcrip_reg; cl00361 889932005369 DsrE/DsrF-like family; Region: DrsE; cl00672 889932005370 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 889932005371 catabolite control protein A; Region: ccpA; TIGR01481 889932005372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932005373 DNA binding site [nucleotide binding] 889932005374 domain linker motif; other site 889932005375 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 889932005376 dimerization interface [polypeptide binding]; other site 889932005377 effector binding site; other site 889932005378 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 889932005379 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 889932005380 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 889932005381 active site 889932005382 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932005383 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932005384 DNA binding residues [nucleotide binding] 889932005385 putative dimer interface [polypeptide binding]; other site 889932005386 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 889932005387 Mechanosensitive ion channel; Region: MS_channel; pfam00924 889932005388 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889932005389 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 889932005390 metal binding site [ion binding]; metal-binding site 889932005391 putative dimer interface [polypeptide binding]; other site 889932005392 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 889932005393 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 889932005394 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 889932005395 active site 889932005396 trimer interface [polypeptide binding]; other site 889932005397 substrate binding site [chemical binding]; other site 889932005398 CoA binding site [chemical binding]; other site 889932005399 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 889932005400 FOG: CBS domain [General function prediction only]; Region: COG0517 889932005401 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 889932005402 active site 889932005403 metal binding site [ion binding]; metal-binding site 889932005404 homotetramer interface [polypeptide binding]; other site 889932005405 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 889932005406 active site 889932005407 dimerization interface [polypeptide binding]; other site 889932005408 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 889932005409 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 889932005410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889932005411 catalytic residues [active] 889932005412 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 889932005413 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005414 Walker A/P-loop; other site 889932005415 ATP binding site [chemical binding]; other site 889932005416 Q-loop/lid; other site 889932005417 ABC transporter signature motif; other site 889932005418 Walker B; other site 889932005419 D-loop; other site 889932005420 H-loop/switch region; other site 889932005421 Smr domain; Region: Smr; cl02619 889932005422 Cell division protein ZapA; Region: ZapA; cl01146 889932005423 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 889932005424 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 889932005425 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 889932005426 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 889932005427 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 889932005428 motif 1; other site 889932005429 active site 889932005430 motif 2; other site 889932005431 motif 3; other site 889932005432 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 889932005433 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 889932005434 DEAD-like helicases superfamily; Region: DEXDc; smart00487 889932005435 ATP binding site [chemical binding]; other site 889932005436 Mg++ binding site [ion binding]; other site 889932005437 motif III; other site 889932005438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 889932005439 nucleotide binding region [chemical binding]; other site 889932005440 ATP-binding site [chemical binding]; other site 889932005441 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 889932005442 DHH family; Region: DHH; pfam01368 889932005443 DHHA1 domain; Region: DHHA1; pfam02272 889932005444 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 889932005445 active site 889932005446 DNA polymerase IV; Validated; Region: PRK02406 889932005447 DNA binding site [nucleotide binding] 889932005448 Preprotein translocase subunit; Region: YajC; cl00806 889932005449 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 889932005450 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 889932005451 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 889932005452 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 889932005453 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 889932005454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932005455 Walker A motif; other site 889932005456 ATP binding site [chemical binding]; other site 889932005457 Walker B motif; other site 889932005458 arginine finger; other site 889932005459 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 889932005460 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 889932005461 RuvA N terminal domain; Region: RuvA_N; pfam01330 889932005462 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 889932005463 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 889932005464 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 889932005465 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 889932005466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889932005467 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 889932005468 ATP binding site [chemical binding]; other site 889932005469 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 889932005470 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 889932005471 MutS domain I; Region: MutS_I; pfam01624 889932005472 MutS domain II; Region: MutS_II; pfam05188 889932005473 MutS family domain IV; Region: MutS_IV; pfam05190 889932005474 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 889932005475 Walker A/P-loop; other site 889932005476 ATP binding site [chemical binding]; other site 889932005477 Q-loop/lid; other site 889932005478 ABC transporter signature motif; other site 889932005479 Walker B; other site 889932005480 D-loop; other site 889932005481 H-loop/switch region; other site 889932005482 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 889932005483 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932005484 putative active site [active] 889932005485 metal binding site [ion binding]; metal-binding site 889932005486 homodimer binding site [polypeptide binding]; other site 889932005487 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 889932005488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 889932005489 Zn2+ binding site [ion binding]; other site 889932005490 Mg2+ binding site [ion binding]; other site 889932005491 recombinase A; Provisional; Region: recA; PRK09354 889932005492 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 889932005493 hexamer interface [polypeptide binding]; other site 889932005494 Walker A motif; other site 889932005495 ATP binding site [chemical binding]; other site 889932005496 Walker B motif; other site 889932005497 competence damage-inducible protein A; Provisional; Region: PRK00549 889932005498 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 889932005499 putative MPT binding site; other site 889932005500 Competence-damaged protein; Region: CinA; cl00666 889932005501 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 889932005502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932005503 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 889932005504 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 889932005505 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 889932005506 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 889932005507 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 889932005508 aspartate kinase; Reviewed; Region: PRK09034 889932005509 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 889932005510 putative catalytic residues [active] 889932005511 putative nucleotide binding site [chemical binding]; other site 889932005512 putative aspartate binding site [chemical binding]; other site 889932005513 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 889932005514 allosteric regulatory residue; other site 889932005515 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 889932005516 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932005517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932005518 substrate binding pocket [chemical binding]; other site 889932005519 membrane-bound complex binding site; other site 889932005520 hinge residues; other site 889932005521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932005522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005523 Walker A/P-loop; other site 889932005524 ATP binding site [chemical binding]; other site 889932005525 Q-loop/lid; other site 889932005526 ABC transporter signature motif; other site 889932005527 Walker B; other site 889932005528 D-loop; other site 889932005529 H-loop/switch region; other site 889932005530 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889932005531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932005532 dimer interface [polypeptide binding]; other site 889932005533 conserved gate region; other site 889932005534 putative PBP binding loops; other site 889932005535 ABC-ATPase subunit interface; other site 889932005536 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 889932005537 Switch I; other site 889932005538 Switch II; other site 889932005539 septum formation inhibitor; Reviewed; Region: minC; PRK00513 889932005540 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 889932005541 rod shape-determining protein MreD; Region: MreD; cl01087 889932005542 rod shape-determining protein MreC; Provisional; Region: PRK13922 889932005543 rod shape-determining protein MreC; Region: MreC; pfam04085 889932005544 rod shape-determining protein MreB; Provisional; Region: PRK13927 889932005545 Cell division protein FtsA; Region: FtsA; cl11496 889932005546 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 889932005547 MPN+ (JAMM) motif; other site 889932005548 Zinc-binding site [ion binding]; other site 889932005549 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 889932005550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932005551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889932005552 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 889932005553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 889932005554 active site 889932005555 HIGH motif; other site 889932005556 nucleotide binding site [chemical binding]; other site 889932005557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 889932005558 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 889932005559 active site 889932005560 KMSKS motif; other site 889932005561 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 889932005562 tRNA binding surface [nucleotide binding]; other site 889932005563 anticodon binding site; other site 889932005564 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 889932005565 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 889932005566 dimer interface [polypeptide binding]; other site 889932005567 catalytic triad [active] 889932005568 peroxidatic and resolving cysteines [active] 889932005569 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 889932005570 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 889932005571 THUMP domain; Region: THUMP; cl12076 889932005572 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 889932005573 Ligand Binding Site [chemical binding]; other site 889932005574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932005575 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 889932005576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932005577 catalytic residue [active] 889932005578 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 889932005579 GAF domain; Region: GAF; cl15785 889932005580 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 889932005581 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 889932005582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 889932005583 RNA binding surface [nucleotide binding]; other site 889932005584 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 889932005585 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 889932005586 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 889932005587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932005588 dimerization interface [polypeptide binding]; other site 889932005589 putative DNA binding site [nucleotide binding]; other site 889932005590 putative Zn2+ binding site [ion binding]; other site 889932005591 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932005592 active site 889932005593 catalytic site [active] 889932005594 maltodextrin glucosidase; Provisional; Region: PRK10785 889932005595 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 889932005596 active pocket/dimerization site; other site 889932005597 active site 889932005598 phosphorylation site [posttranslational modification] 889932005599 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 889932005600 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 889932005601 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 889932005602 active site 889932005603 phosphorylation site [posttranslational modification] 889932005604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932005605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932005606 DNA binding site [nucleotide binding] 889932005607 domain linker motif; other site 889932005608 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 889932005609 putative dimerization interface [polypeptide binding]; other site 889932005610 putative ligand binding site [chemical binding]; other site 889932005611 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 889932005612 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 889932005613 recombination factor protein RarA; Reviewed; Region: PRK13342 889932005614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932005615 Walker A motif; other site 889932005616 ATP binding site [chemical binding]; other site 889932005617 Walker B motif; other site 889932005618 arginine finger; other site 889932005619 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 889932005620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932005621 Ligand Binding Site [chemical binding]; other site 889932005622 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 889932005623 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932005624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932005625 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889932005626 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 889932005627 putative active site [active] 889932005628 catalytic site [active] 889932005629 putative metal binding site [ion binding]; other site 889932005630 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 889932005631 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 889932005632 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932005633 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 889932005634 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 889932005635 putative NAD(P) binding site [chemical binding]; other site 889932005636 dimer interface [polypeptide binding]; other site 889932005637 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 889932005638 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 889932005639 tetramer (dimer of dimers) interface [polypeptide binding]; other site 889932005640 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 889932005641 NAD binding site [chemical binding]; other site 889932005642 dimer interface [polypeptide binding]; other site 889932005643 substrate binding site [chemical binding]; other site 889932005644 NMT1-like family; Region: NMT1_2; cl15260 889932005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932005646 dimer interface [polypeptide binding]; other site 889932005647 conserved gate region; other site 889932005648 ABC-ATPase subunit interface; other site 889932005649 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 889932005650 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 889932005651 Walker A/P-loop; other site 889932005652 ATP binding site [chemical binding]; other site 889932005653 Q-loop/lid; other site 889932005654 ABC transporter signature motif; other site 889932005655 Walker B; other site 889932005656 D-loop; other site 889932005657 H-loop/switch region; other site 889932005658 NIL domain; Region: NIL; cl09633 889932005659 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 889932005660 lipoyl attachment site [posttranslational modification]; other site 889932005661 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 889932005662 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 889932005663 Haemolytic domain; Region: Haemolytic; cl00506 889932005664 rod shape-determining protein MreB; Provisional; Region: PRK13930 889932005665 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 889932005666 ATP binding site [chemical binding]; other site 889932005667 Cell division protein FtsA; Region: FtsA; cl11496 889932005668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889932005669 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932005670 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 889932005671 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 889932005672 hinge; other site 889932005673 active site 889932005674 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 889932005675 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 889932005676 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 889932005677 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 889932005678 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 889932005679 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 889932005680 alpha subunit interaction interface [polypeptide binding]; other site 889932005681 Walker A motif; other site 889932005682 ATP binding site [chemical binding]; other site 889932005683 Walker B motif; other site 889932005684 inhibitor binding site; inhibition site 889932005685 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889932005686 ATP synthase; Region: ATP-synt; cl00365 889932005687 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 889932005688 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 889932005689 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 889932005690 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 889932005691 beta subunit interaction interface [polypeptide binding]; other site 889932005692 Walker A motif; other site 889932005693 ATP binding site [chemical binding]; other site 889932005694 Walker B motif; other site 889932005695 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 889932005696 Plant ATP synthase F0; Region: YMF19; cl07975 889932005697 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 889932005698 Plant ATP synthase F0; Region: YMF19; cl07975 889932005699 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 889932005700 ATP synthase subunit C; Region: ATP-synt_C; cl00466 889932005701 ATP synthase A chain; Region: ATP-synt_A; cl00413 889932005702 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 889932005703 uracil transporter; Provisional; Region: PRK10720 889932005704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932005705 active site 889932005706 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 889932005707 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 889932005708 dimer interface [polypeptide binding]; other site 889932005709 active site 889932005710 glycine-pyridoxal phosphate binding site [chemical binding]; other site 889932005711 folate binding site [chemical binding]; other site 889932005712 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 889932005713 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 889932005714 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 889932005715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932005716 S-adenosylmethionine binding site [chemical binding]; other site 889932005717 peptide chain release factor 1; Validated; Region: prfA; PRK00591 889932005718 RF-1 domain; Region: RF-1; cl02875 889932005719 RF-1 domain; Region: RF-1; cl02875 889932005720 thymidine kinase; Provisional; Region: PRK04296 889932005721 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 889932005722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 889932005723 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 889932005724 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 889932005725 catalytic triad [active] 889932005726 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 889932005727 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 889932005728 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932005729 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 889932005730 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 889932005731 homodimer interface [polypeptide binding]; other site 889932005732 substrate-cofactor binding pocket; other site 889932005733 catalytic residue [active] 889932005734 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932005735 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932005736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005737 Walker A/P-loop; other site 889932005738 ATP binding site [chemical binding]; other site 889932005739 Q-loop/lid; other site 889932005740 ABC transporter signature motif; other site 889932005741 Walker B; other site 889932005742 D-loop; other site 889932005743 H-loop/switch region; other site 889932005744 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932005745 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932005746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005747 Walker A/P-loop; other site 889932005748 ATP binding site [chemical binding]; other site 889932005749 Q-loop/lid; other site 889932005750 ABC transporter signature motif; other site 889932005751 Walker B; other site 889932005752 D-loop; other site 889932005753 H-loop/switch region; other site 889932005754 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 889932005755 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 889932005756 putative active site [active] 889932005757 putative metal binding site [ion binding]; other site 889932005758 Bacteriophage holin; Region: Phage_holin_1; cl02344 889932005759 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889932005760 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889932005761 active site 889932005762 Bacterial SH3 domain; Region: SH3_3; cl02551 889932005763 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932005764 putative peptidoglycan binding site; other site 889932005765 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 889932005766 gp58-like protein; Region: Gp58; pfam07902 889932005767 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 889932005768 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 889932005769 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932005770 Phage tail protein; Region: Phage_tail_3; pfam08813 889932005771 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 889932005772 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 889932005773 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 889932005774 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 889932005775 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 889932005776 Protein of unknown function (DUF464); Region: DUF464; cl01080 889932005777 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 889932005778 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 889932005779 Terminase small subunit; Region: Terminase_2; cl01513 889932005780 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 889932005781 Endodeoxyribonuclease RusA; Region: RusA; cl01885 889932005782 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 889932005783 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 889932005784 RecT family; Region: RecT; cl04285 889932005785 PcfK-like protein; Region: PcfK; pfam14058 889932005786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932005787 Domain of unknown function (DUF771); Region: DUF771; cl09962 889932005788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932005789 non-specific DNA binding site [nucleotide binding]; other site 889932005790 salt bridge; other site 889932005791 sequence-specific DNA binding site [nucleotide binding]; other site 889932005792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932005793 non-specific DNA binding site [nucleotide binding]; other site 889932005794 salt bridge; other site 889932005795 sequence-specific DNA binding site [nucleotide binding]; other site 889932005796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932005797 non-specific DNA binding site [nucleotide binding]; other site 889932005798 salt bridge; other site 889932005799 sequence-specific DNA binding site [nucleotide binding]; other site 889932005800 Domain of unknown function (DUF955); Region: DUF955; cl01076 889932005801 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 889932005802 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 889932005803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 889932005804 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 889932005805 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 889932005806 Int/Topo IB signature motif; other site 889932005807 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889932005808 Helix-turn-helix domains; Region: HTH; cl00088 889932005809 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 889932005810 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932005811 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932005812 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932005813 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932005814 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932005815 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932005816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932005817 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932005818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005819 Walker A/P-loop; other site 889932005820 ATP binding site [chemical binding]; other site 889932005821 Q-loop/lid; other site 889932005822 ABC transporter signature motif; other site 889932005823 Walker B; other site 889932005824 D-loop; other site 889932005825 H-loop/switch region; other site 889932005826 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932005827 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 889932005828 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932005829 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932005830 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932005831 Walker A/P-loop; other site 889932005832 ATP binding site [chemical binding]; other site 889932005833 Q-loop/lid; other site 889932005834 ABC transporter signature motif; other site 889932005835 Walker B; other site 889932005836 D-loop; other site 889932005837 H-loop/switch region; other site 889932005838 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932005839 FtsX-like permease family; Region: FtsX; cl15850 889932005840 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 889932005841 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 889932005842 active site 889932005843 dimer interface [polypeptide binding]; other site 889932005844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 889932005845 dimer interface [polypeptide binding]; other site 889932005846 active site 889932005847 Sugar transport protein; Region: Sugar_transport; pfam06800 889932005848 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 889932005849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 889932005850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 889932005851 dimerization interface [polypeptide binding]; other site 889932005852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932005853 dimer interface [polypeptide binding]; other site 889932005854 phosphorylation site [posttranslational modification] 889932005855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932005856 ATP binding site [chemical binding]; other site 889932005857 Mg2+ binding site [ion binding]; other site 889932005858 G-X-G motif; other site 889932005859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932005860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932005861 active site 889932005862 phosphorylation site [posttranslational modification] 889932005863 intermolecular recognition site; other site 889932005864 dimerization interface [polypeptide binding]; other site 889932005865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932005866 DNA binding site [nucleotide binding] 889932005867 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 889932005868 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 889932005869 EamA-like transporter family; Region: EamA; cl01037 889932005870 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932005871 EamA-like transporter family; Region: EamA; cl01037 889932005872 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889932005873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932005874 benzoate transport; Region: 2A0115; TIGR00895 889932005875 putative substrate translocation pore; other site 889932005876 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 889932005877 nudix motif; other site 889932005878 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 889932005879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932005880 NlpC/P60 family; Region: NLPC_P60; cl11438 889932005881 Helix-turn-helix domains; Region: HTH; cl00088 889932005882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 889932005883 metal binding site [ion binding]; metal-binding site 889932005884 active site 889932005885 I-site; other site 889932005886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 889932005887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005888 Walker A/P-loop; other site 889932005889 ATP binding site [chemical binding]; other site 889932005890 Q-loop/lid; other site 889932005891 ABC transporter signature motif; other site 889932005892 Walker B; other site 889932005893 D-loop; other site 889932005894 H-loop/switch region; other site 889932005895 ABC transporter; Region: ABC_tran_2; pfam12848 889932005896 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932005897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932005898 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889932005899 Coenzyme A binding pocket [chemical binding]; other site 889932005900 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 889932005901 dimer interface [polypeptide binding]; other site 889932005902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 889932005903 metal binding site [ion binding]; metal-binding site 889932005904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 889932005905 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932005906 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 889932005907 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932005908 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932005909 active site turn [active] 889932005910 phosphorylation site [posttranslational modification] 889932005911 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932005912 HPr interaction site; other site 889932005913 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932005914 active site 889932005915 phosphorylation site [posttranslational modification] 889932005916 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 889932005917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005918 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 889932005919 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932005920 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 889932005921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 889932005923 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 889932005924 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 889932005925 homodimer interface [polypeptide binding]; other site 889932005926 substrate-cofactor binding pocket; other site 889932005927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932005928 catalytic residue [active] 889932005929 Homoserine O-succinyltransferase; Region: HTS; pfam04204 889932005930 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 889932005931 proposed active site lysine [active] 889932005932 conserved cys residue [active] 889932005933 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 889932005934 zinc binding site [ion binding]; other site 889932005935 putative ligand binding site [chemical binding]; other site 889932005936 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 889932005937 TM-ABC transporter signature motif; other site 889932005938 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 889932005939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932005940 Walker A/P-loop; other site 889932005941 ATP binding site [chemical binding]; other site 889932005942 Q-loop/lid; other site 889932005943 ABC transporter signature motif; other site 889932005944 Walker B; other site 889932005945 D-loop; other site 889932005946 H-loop/switch region; other site 889932005947 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932005948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932005949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932005950 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 889932005951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932005952 Integral membrane protein TerC family; Region: TerC; cl10468 889932005953 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932005954 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932005955 active site 889932005956 substrate binding site [chemical binding]; other site 889932005957 trimer interface [polypeptide binding]; other site 889932005958 CoA binding site [chemical binding]; other site 889932005959 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 889932005960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932005962 homodimer interface [polypeptide binding]; other site 889932005963 catalytic residue [active] 889932005964 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 889932005965 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 889932005966 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 889932005967 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 889932005968 substrate binding site [chemical binding]; other site 889932005969 glutamase interaction surface [polypeptide binding]; other site 889932005970 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 889932005971 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 889932005972 catalytic residues [active] 889932005973 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 889932005974 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 889932005975 putative active site [active] 889932005976 oxyanion strand; other site 889932005977 catalytic triad [active] 889932005978 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 889932005979 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 889932005980 putative active site pocket [active] 889932005981 4-fold oligomerization interface [polypeptide binding]; other site 889932005982 metal binding residues [ion binding]; metal-binding site 889932005983 3-fold/trimer interface [polypeptide binding]; other site 889932005984 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 889932005985 histidinol dehydrogenase; Region: hisD; TIGR00069 889932005986 NAD binding site [chemical binding]; other site 889932005987 dimerization interface [polypeptide binding]; other site 889932005988 product binding site; other site 889932005989 substrate binding site [chemical binding]; other site 889932005990 zinc binding site [ion binding]; other site 889932005991 catalytic residues [active] 889932005992 ATP phosphoribosyltransferase; Region: HisG; cl15266 889932005993 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 889932005994 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 889932005995 dimer interface [polypeptide binding]; other site 889932005996 motif 1; other site 889932005997 active site 889932005998 motif 2; other site 889932005999 motif 3; other site 889932006000 histidinol-phosphatase; Reviewed; Region: PRK08123 889932006001 PHP-associated; Region: PHP_C; pfam13263 889932006002 VanZ like family; Region: VanZ; cl01971 889932006003 RDD family; Region: RDD; cl00746 889932006004 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 889932006005 Protein of unknown function (DUF419); Region: DUF419; cl15265 889932006006 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 889932006007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006008 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 889932006009 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 889932006010 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 889932006011 active site 889932006012 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 889932006013 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 889932006014 Collagen binding domain; Region: Collagen_bind; pfam05737 889932006015 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889932006016 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 889932006017 Cornifin (SPRR) family; Region: Cornifin; pfam02389 889932006018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932006019 Coenzyme A binding pocket [chemical binding]; other site 889932006020 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 889932006021 Sulfatase; Region: Sulfatase; cl10460 889932006022 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 889932006023 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 889932006024 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 889932006025 putative active site [active] 889932006026 catalytic site [active] 889932006027 putative metal binding site [ion binding]; other site 889932006028 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 889932006029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932006031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006032 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 889932006033 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 889932006034 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 889932006035 dimer interface [polypeptide binding]; other site 889932006036 FMN binding site [chemical binding]; other site 889932006037 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 889932006038 active site 889932006039 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 889932006040 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 889932006041 RNA/DNA hybrid binding site [nucleotide binding]; other site 889932006042 active site 889932006043 Sugar transport protein; Region: Sugar_transport; pfam06800 889932006044 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 889932006045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889932006046 FeS/SAM binding site; other site 889932006047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889932006048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006049 DNA-binding site [nucleotide binding]; DNA binding site 889932006050 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889932006051 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 889932006052 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 889932006053 dimer interface [polypeptide binding]; other site 889932006054 active site 889932006055 glycine loop; other site 889932006056 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 889932006057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932006058 DNA binding residues [nucleotide binding] 889932006059 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 889932006060 active site 889932006061 intersubunit interactions; other site 889932006062 catalytic residue [active] 889932006063 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932006064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932006066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932006067 DNA binding site [nucleotide binding] 889932006068 domain linker motif; other site 889932006069 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 889932006070 putative dimerization interface [polypeptide binding]; other site 889932006071 putative ligand binding site [chemical binding]; other site 889932006072 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889932006073 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932006074 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932006075 putative active site [active] 889932006076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006077 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 889932006078 putative oxidoreductase; Provisional; Region: PRK10206 889932006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006080 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 889932006081 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932006082 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 889932006083 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 889932006084 TPP-binding site; other site 889932006085 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889932006086 PYR/PP interface [polypeptide binding]; other site 889932006087 dimer interface [polypeptide binding]; other site 889932006088 TPP binding site [chemical binding]; other site 889932006089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889932006090 Isochorismatase family; Region: Isochorismatase; pfam00857 889932006091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 889932006092 catalytic triad [active] 889932006093 conserved cis-peptide bond; other site 889932006094 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 889932006095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006096 Walker A/P-loop; other site 889932006097 ATP binding site [chemical binding]; other site 889932006098 Q-loop/lid; other site 889932006099 ABC transporter signature motif; other site 889932006100 Walker B; other site 889932006101 D-loop; other site 889932006102 H-loop/switch region; other site 889932006103 Predicted transcriptional regulators [Transcription]; Region: COG1725 889932006104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006105 DNA-binding site [nucleotide binding]; DNA binding site 889932006106 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932006107 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006108 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889932006109 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 889932006110 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 889932006111 active site 889932006112 Zn binding site [ion binding]; other site 889932006113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 889932006114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932006115 non-specific DNA binding site [nucleotide binding]; other site 889932006116 salt bridge; other site 889932006117 sequence-specific DNA binding site [nucleotide binding]; other site 889932006118 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 889932006119 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889932006120 PYR/PP interface [polypeptide binding]; other site 889932006121 dimer interface [polypeptide binding]; other site 889932006122 tetramer interface [polypeptide binding]; other site 889932006123 TPP binding site [chemical binding]; other site 889932006124 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932006125 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889932006126 TPP-binding site [chemical binding]; other site 889932006127 esterase; Provisional; Region: PRK10566 889932006128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889932006130 catalytic residues [active] 889932006131 cystathionine gamma-synthase; Reviewed; Region: PRK08247 889932006132 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 889932006133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932006134 catalytic residue [active] 889932006135 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 889932006136 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 889932006137 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889932006138 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 889932006139 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932006140 Bacterial SH3 domain; Region: SH3_3; cl02551 889932006141 Bacterial SH3 domain; Region: SH3_3; cl02551 889932006142 Bacterial SH3 domain; Region: SH3_3; cl02551 889932006143 Bacterial SH3 domain; Region: SH3_3; cl02551 889932006144 Bacterial SH3 domain; Region: SH3_3; cl02551 889932006145 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 889932006146 active pocket/dimerization site; other site 889932006147 active site 889932006148 phosphorylation site [posttranslational modification] 889932006149 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 889932006150 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 889932006151 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 889932006152 active site 889932006153 phosphorylation site [posttranslational modification] 889932006154 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932006155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006156 DNA-binding site [nucleotide binding]; DNA binding site 889932006157 UTRA domain; Region: UTRA; cl01230 889932006158 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932006159 Ligand Binding Site [chemical binding]; other site 889932006160 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 889932006161 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 889932006162 active site 889932006163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932006164 non-specific DNA binding site [nucleotide binding]; other site 889932006165 salt bridge; other site 889932006166 sequence-specific DNA binding site [nucleotide binding]; other site 889932006167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 889932006168 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 889932006169 putative ADP-binding pocket [chemical binding]; other site 889932006170 putative phosphoketolase; Provisional; Region: PRK05261 889932006171 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 889932006172 TPP-binding site; other site 889932006173 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 889932006174 XFP C-terminal domain; Region: XFP_C; pfam09363 889932006175 Predicted esterase [General function prediction only]; Region: COG0627 889932006176 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006178 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932006179 DNA-binding site [nucleotide binding]; DNA binding site 889932006180 UTRA domain; Region: UTRA; cl01230 889932006181 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 889932006182 putative deacylase active site [active] 889932006183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932006184 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932006185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932006186 active site 889932006187 phosphorylation site [posttranslational modification] 889932006188 intermolecular recognition site; other site 889932006189 dimerization interface [polypeptide binding]; other site 889932006190 LytTr DNA-binding domain; Region: LytTR; cl04498 889932006191 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 889932006192 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 889932006193 putative dimer interface [polypeptide binding]; other site 889932006194 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 889932006195 Domain of unknown function DUF21; Region: DUF21; pfam01595 889932006196 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 889932006197 Transporter associated domain; Region: CorC_HlyC; cl08393 889932006198 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006199 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 889932006200 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932006201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932006202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932006203 putative substrate translocation pore; other site 889932006204 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932006205 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932006206 DNA binding residues [nucleotide binding] 889932006207 putative dimer interface [polypeptide binding]; other site 889932006208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932006209 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 889932006210 putative NAD(P) binding site [chemical binding]; other site 889932006211 SdpI/YhfL protein family; Region: SdpI; pfam13630 889932006212 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 889932006213 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 889932006214 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 889932006215 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 889932006216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006217 DNA-binding site [nucleotide binding]; DNA binding site 889932006218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932006219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932006220 homodimer interface [polypeptide binding]; other site 889932006221 aromatic amino acid aminotransferase; Validated; Region: PRK07309 889932006222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932006223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932006224 homodimer interface [polypeptide binding]; other site 889932006225 catalytic residue [active] 889932006226 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 889932006227 dimer interface [polypeptide binding]; other site 889932006228 active site 889932006229 catalytic residue [active] 889932006230 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 889932006231 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889932006232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932006233 Helix-turn-helix domains; Region: HTH; cl00088 889932006234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932006235 dimerization interface [polypeptide binding]; other site 889932006236 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 889932006237 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932006238 NAD(P) binding site [chemical binding]; other site 889932006239 putative active site [active] 889932006240 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 889932006241 Transposase domain (DUF772); Region: DUF772; cl15789 889932006242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 889932006243 Transposase domain (DUF772); Region: DUF772; cl15789 889932006244 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 889932006245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006246 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889932006247 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 889932006248 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 889932006249 Protein of unknown function, DUF606; Region: DUF606; cl01273 889932006250 Protein of unknown function, DUF606; Region: DUF606; cl01273 889932006251 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 889932006252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932006253 active site 889932006254 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 889932006255 active site 889932006256 dimer interface [polypeptide binding]; other site 889932006257 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 889932006258 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 889932006259 heterodimer interface [polypeptide binding]; other site 889932006260 active site 889932006261 FMN binding site [chemical binding]; other site 889932006262 homodimer interface [polypeptide binding]; other site 889932006263 substrate binding site [chemical binding]; other site 889932006264 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 889932006265 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932006266 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932006267 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 889932006268 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 889932006269 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932006270 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 889932006271 IMP binding site; other site 889932006272 dimer interface [polypeptide binding]; other site 889932006273 interdomain contacts; other site 889932006274 partial ornithine binding site; other site 889932006275 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 889932006276 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 889932006277 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 889932006278 catalytic site [active] 889932006279 subunit interface [polypeptide binding]; other site 889932006280 dihydroorotase; Validated; Region: pyrC; PRK09357 889932006281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889932006282 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 889932006283 active site 889932006284 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 889932006285 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 889932006286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932006288 active site 889932006289 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 889932006290 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 889932006291 Helix-turn-helix domains; Region: HTH; cl00088 889932006292 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 889932006293 xanthine permease; Region: pbuX; TIGR03173 889932006294 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 889932006295 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 889932006296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006297 NAD(P) binding site [chemical binding]; other site 889932006298 active site 889932006299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 889932006300 N-glycosyltransferase; Provisional; Region: PRK11204 889932006301 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 889932006302 DXD motif; other site 889932006303 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 889932006304 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 889932006305 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 889932006306 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932006307 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 889932006308 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 889932006309 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 889932006310 purine monophosphate binding site [chemical binding]; other site 889932006311 dimer interface [polypeptide binding]; other site 889932006312 putative catalytic residues [active] 889932006313 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 889932006314 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 889932006315 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 889932006316 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 889932006317 active site 889932006318 substrate binding site [chemical binding]; other site 889932006319 cosubstrate binding site; other site 889932006320 catalytic site [active] 889932006321 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 889932006322 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 889932006323 dimerization interface [polypeptide binding]; other site 889932006324 putative ATP binding site [chemical binding]; other site 889932006325 amidophosphoribosyltransferase; Provisional; Region: PRK07272 889932006326 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 889932006327 active site 889932006328 tetramer interface [polypeptide binding]; other site 889932006329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 889932006330 active site 889932006331 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 889932006332 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 889932006333 putative active site [active] 889932006334 catalytic triad [active] 889932006335 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 889932006336 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 889932006337 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 889932006338 ATP binding site [chemical binding]; other site 889932006339 active site 889932006340 substrate binding site [chemical binding]; other site 889932006341 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 889932006342 ATP-grasp domain; Region: ATP-grasp_4; cl03087 889932006343 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006344 PAS domain; Region: PAS_10; pfam13596 889932006345 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006346 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 889932006347 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 889932006348 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 889932006349 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 889932006350 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 889932006351 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 889932006352 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 889932006353 active site 889932006354 zinc binding site [ion binding]; other site 889932006355 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006356 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 889932006357 active site 889932006358 homotetramer interface [polypeptide binding]; other site 889932006359 homodimer interface [polypeptide binding]; other site 889932006360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932006361 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932006362 Walker A/P-loop; other site 889932006363 ATP binding site [chemical binding]; other site 889932006364 Q-loop/lid; other site 889932006365 ABC transporter signature motif; other site 889932006366 Walker B; other site 889932006367 D-loop; other site 889932006368 H-loop/switch region; other site 889932006369 FtsX-like permease family; Region: FtsX; cl15850 889932006370 Predicted transcriptional regulators [Transcription]; Region: COG1725 889932006371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006372 DNA-binding site [nucleotide binding]; DNA binding site 889932006373 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 889932006374 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 889932006375 Walker A/P-loop; other site 889932006376 ATP binding site [chemical binding]; other site 889932006377 Q-loop/lid; other site 889932006378 ABC transporter signature motif; other site 889932006379 Walker B; other site 889932006380 D-loop; other site 889932006381 H-loop/switch region; other site 889932006382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932006383 Ligand Binding Site [chemical binding]; other site 889932006384 GtrA-like protein; Region: GtrA; cl00971 889932006385 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 889932006386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932006387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932006388 homodimer interface [polypeptide binding]; other site 889932006389 catalytic residue [active] 889932006390 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 889932006391 homodimer interface [polypeptide binding]; other site 889932006392 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 889932006393 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 889932006394 active site 889932006395 homodimer interface [polypeptide binding]; other site 889932006396 catalytic site [active] 889932006397 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 889932006398 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 889932006399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932006400 catalytic residue [active] 889932006401 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932006402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006403 active site 889932006404 motif I; other site 889932006405 motif II; other site 889932006406 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932006407 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 889932006408 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 889932006409 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932006410 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932006411 active site 889932006412 substrate binding site [chemical binding]; other site 889932006413 trimer interface [polypeptide binding]; other site 889932006414 CoA binding site [chemical binding]; other site 889932006415 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 889932006416 dimer interface [polypeptide binding]; other site 889932006417 ADP-ribose binding site [chemical binding]; other site 889932006418 active site 889932006419 nudix motif; other site 889932006420 metal binding site [ion binding]; metal-binding site 889932006421 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889932006422 nucleotide binding site/active site [active] 889932006423 HIT family signature motif; other site 889932006424 catalytic residue [active] 889932006425 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 889932006426 classical (c) SDRs; Region: SDR_c; cd05233 889932006427 NAD(P) binding site [chemical binding]; other site 889932006428 active site 889932006429 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 889932006430 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 889932006431 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932006432 Sterol carrier protein domain; Region: SCP2_2; pfam13530 889932006433 H+ Antiporter protein; Region: 2A0121; TIGR00900 889932006434 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 889932006435 Helix-turn-helix domains; Region: HTH; cl00088 889932006436 3H domain; Region: 3H; pfam02829 889932006437 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 889932006438 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 889932006439 active site 889932006440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932006441 Helix-turn-helix domains; Region: HTH; cl00088 889932006442 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932006443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006444 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 889932006445 Walker A/P-loop; other site 889932006446 ATP binding site [chemical binding]; other site 889932006447 Q-loop/lid; other site 889932006448 ABC transporter signature motif; other site 889932006449 Walker B; other site 889932006450 D-loop; other site 889932006451 H-loop/switch region; other site 889932006452 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 889932006453 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 889932006454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 889932006455 catalytic residue [active] 889932006456 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932006457 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932006458 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 889932006459 active site 889932006460 methionine cluster; other site 889932006461 phosphorylation site [posttranslational modification] 889932006462 metal binding site [ion binding]; metal-binding site 889932006463 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 889932006464 active site 889932006465 P-loop; other site 889932006466 phosphorylation site [posttranslational modification] 889932006467 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932006468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006469 DNA-binding site [nucleotide binding]; DNA binding site 889932006470 UTRA domain; Region: UTRA; cl01230 889932006471 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 889932006472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 889932006473 active site 889932006474 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932006475 catalytic core [active] 889932006476 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932006477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006478 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932006479 active site 889932006480 motif I; other site 889932006481 motif II; other site 889932006482 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932006483 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 889932006484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006485 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 889932006486 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932006487 EamA-like transporter family; Region: EamA; cl01037 889932006488 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 889932006489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006490 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 889932006491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006493 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006494 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932006495 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932006496 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932006497 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932006498 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932006499 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932006500 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932006501 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 889932006502 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 889932006503 active site 889932006504 catalytic residue [active] 889932006505 dimer interface [polypeptide binding]; other site 889932006506 inner membrane transporter YjeM; Provisional; Region: PRK15238 889932006507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889932006508 Helix-turn-helix domains; Region: HTH; cl00088 889932006509 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006511 active site 889932006512 catalytic tetrad [active] 889932006513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006514 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006515 active site 889932006516 catalytic tetrad [active] 889932006517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932006518 Helix-turn-helix domains; Region: HTH; cl00088 889932006519 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 889932006520 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 889932006521 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 889932006522 active site 889932006523 HIGH motif; other site 889932006524 dimer interface [polypeptide binding]; other site 889932006525 KMSKS motif; other site 889932006526 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 889932006527 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 889932006528 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889932006529 active site 889932006530 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 889932006531 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 889932006532 putative active site [active] 889932006533 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 889932006534 Protein of unknown function (DUF554); Region: DUF554; cl00784 889932006535 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932006536 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 889932006537 DNA binding residues [nucleotide binding] 889932006538 drug binding residues [chemical binding]; other site 889932006539 dimer interface [polypeptide binding]; other site 889932006540 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 889932006541 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 889932006542 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 889932006543 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 889932006544 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932006545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932006546 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932006547 Walker A/P-loop; other site 889932006548 ATP binding site [chemical binding]; other site 889932006549 Q-loop/lid; other site 889932006550 ABC transporter signature motif; other site 889932006551 Walker B; other site 889932006552 D-loop; other site 889932006553 H-loop/switch region; other site 889932006554 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 889932006555 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 889932006556 active site 889932006557 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 889932006558 NADP+ binding site [chemical binding]; other site 889932006559 folate binding site [chemical binding]; other site 889932006560 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932006561 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932006562 Membrane transport protein; Region: Mem_trans; cl09117 889932006563 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 889932006564 Aspartase; Region: Aspartase; cd01357 889932006565 active sites [active] 889932006566 tetramer interface [polypeptide binding]; other site 889932006567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932006568 putative substrate translocation pore; other site 889932006569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932006570 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 889932006571 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932006572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932006573 putative substrate translocation pore; other site 889932006574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932006575 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932006576 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889932006577 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 889932006578 Helix-turn-helix domains; Region: HTH; cl00088 889932006579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932006580 dimerization interface [polypeptide binding]; other site 889932006581 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932006582 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932006583 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 889932006584 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 889932006585 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 889932006586 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932006587 putative peptidoglycan binding site; other site 889932006588 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932006589 putative peptidoglycan binding site; other site 889932006590 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 889932006591 DNA binding site [nucleotide binding] 889932006592 active site 889932006593 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 889932006594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006595 Walker A/P-loop; other site 889932006596 ATP binding site [chemical binding]; other site 889932006597 Q-loop/lid; other site 889932006598 ABC transporter signature motif; other site 889932006599 Walker B; other site 889932006600 D-loop; other site 889932006601 H-loop/switch region; other site 889932006602 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 889932006603 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 889932006604 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889932006605 classical (c) SDRs; Region: SDR_c; cd05233 889932006606 NAD(P) binding site [chemical binding]; other site 889932006607 active site 889932006608 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 889932006609 Cupin domain; Region: Cupin_2; cl09118 889932006610 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932006611 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932006612 DNA binding residues [nucleotide binding] 889932006613 putative dimer interface [polypeptide binding]; other site 889932006614 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 889932006615 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 889932006616 metal binding site [ion binding]; metal-binding site 889932006617 dimer interface [polypeptide binding]; other site 889932006618 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932006619 FtsX-like permease family; Region: FtsX; cl15850 889932006620 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 889932006621 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 889932006622 FtsX-like permease family; Region: FtsX; cl15850 889932006623 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932006624 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932006625 Walker A/P-loop; other site 889932006626 ATP binding site [chemical binding]; other site 889932006627 Q-loop/lid; other site 889932006628 ABC transporter signature motif; other site 889932006629 Walker B; other site 889932006630 D-loop; other site 889932006631 H-loop/switch region; other site 889932006632 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 889932006633 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889932006634 minor groove reading motif; other site 889932006635 helix-hairpin-helix signature motif; other site 889932006636 substrate binding pocket [chemical binding]; other site 889932006637 active site 889932006638 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932006639 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932006640 active site 889932006641 substrate binding site [chemical binding]; other site 889932006642 trimer interface [polypeptide binding]; other site 889932006643 CoA binding site [chemical binding]; other site 889932006644 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 889932006645 Catalytic site [active] 889932006646 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 889932006647 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889932006648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932006649 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 889932006650 Coenzyme A binding pocket [chemical binding]; other site 889932006651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932006652 catalytic core [active] 889932006653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932006654 Helix-turn-helix domains; Region: HTH; cl00088 889932006655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932006656 dimerization interface [polypeptide binding]; other site 889932006657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006658 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932006659 NAD(P) binding site [chemical binding]; other site 889932006660 active site 889932006661 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 889932006662 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889932006663 catalytic Zn binding site [ion binding]; other site 889932006664 NAD(P) binding site [chemical binding]; other site 889932006665 structural Zn binding site [ion binding]; other site 889932006666 short chain dehydrogenase; Provisional; Region: PRK06940 889932006667 classical (c) SDRs; Region: SDR_c; cd05233 889932006668 NAD(P) binding site [chemical binding]; other site 889932006669 active site 889932006670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006672 active site 889932006673 catalytic tetrad [active] 889932006674 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 889932006675 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006676 glucose-1-dehydrogenase; Provisional; Region: PRK08936 889932006677 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 889932006678 NAD binding site [chemical binding]; other site 889932006679 homodimer interface [polypeptide binding]; other site 889932006680 active site 889932006681 Sugar transport protein; Region: Sugar_transport; pfam06800 889932006682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006683 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932006684 NAD(P) binding site [chemical binding]; other site 889932006685 active site 889932006686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006687 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006688 active site 889932006689 catalytic tetrad [active] 889932006690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932006691 Helix-turn-helix domains; Region: HTH; cl00088 889932006692 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932006693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932006694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006695 NAD(P) binding site [chemical binding]; other site 889932006696 active site 889932006697 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006698 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006699 active site 889932006700 catalytic tetrad [active] 889932006701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006702 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932006703 active site 889932006704 catalytic tetrad [active] 889932006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932006706 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932006707 putative substrate translocation pore; other site 889932006708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932006710 NAD(P) binding site [chemical binding]; other site 889932006711 active site 889932006712 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932006713 Ligand Binding Site [chemical binding]; other site 889932006714 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932006715 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932006716 active site 889932006717 substrate binding site [chemical binding]; other site 889932006718 trimer interface [polypeptide binding]; other site 889932006719 CoA binding site [chemical binding]; other site 889932006720 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 889932006721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006722 motif II; other site 889932006723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932006724 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 889932006725 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 889932006726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932006727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932006728 homodimer interface [polypeptide binding]; other site 889932006729 catalytic residue [active] 889932006730 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 889932006731 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 889932006732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932006733 active site 889932006734 catalytic tetrad [active] 889932006735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932006736 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932006737 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 889932006738 Walker A/P-loop; other site 889932006739 ATP binding site [chemical binding]; other site 889932006740 Q-loop/lid; other site 889932006741 ABC transporter signature motif; other site 889932006742 Walker B; other site 889932006743 D-loop; other site 889932006744 H-loop/switch region; other site 889932006745 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932006746 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 889932006747 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006748 Walker A/P-loop; other site 889932006749 ATP binding site [chemical binding]; other site 889932006750 Q-loop/lid; other site 889932006751 ABC transporter signature motif; other site 889932006752 Walker B; other site 889932006753 D-loop; other site 889932006754 H-loop/switch region; other site 889932006755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932006756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932006757 putative substrate translocation pore; other site 889932006758 Predicted membrane protein [Function unknown]; Region: COG1511 889932006759 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 889932006760 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889932006761 Predicted membrane protein [Function unknown]; Region: COG1511 889932006762 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 889932006763 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 889932006764 ABC-2 type transporter; Region: ABC2_membrane; cl11417 889932006765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932006766 Helix-turn-helix domains; Region: HTH; cl00088 889932006767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932006768 dimerization interface [polypeptide binding]; other site 889932006769 putative DNA binding site [nucleotide binding]; other site 889932006770 putative Zn2+ binding site [ion binding]; other site 889932006771 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 889932006772 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 889932006773 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889932006774 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932006775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 889932006776 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932006777 CAAX protease self-immunity; Region: Abi; cl00558 889932006778 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 889932006779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006780 Walker A/P-loop; other site 889932006781 ATP binding site [chemical binding]; other site 889932006782 Q-loop/lid; other site 889932006783 ABC transporter signature motif; other site 889932006784 Walker B; other site 889932006785 D-loop; other site 889932006786 H-loop/switch region; other site 889932006787 ABC transporter; Region: ABC_tran_2; pfam12848 889932006788 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 889932006789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006790 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932006791 active site 889932006792 motif I; other site 889932006793 motif II; other site 889932006794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932006795 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 889932006796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006797 Walker A/P-loop; other site 889932006798 ATP binding site [chemical binding]; other site 889932006799 Q-loop/lid; other site 889932006800 chaperone protein DnaJ; Provisional; Region: PRK14283 889932006801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006802 ABC transporter signature motif; other site 889932006803 Walker B; other site 889932006804 D-loop; other site 889932006805 H-loop/switch region; other site 889932006806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006807 Walker A/P-loop; other site 889932006808 ATP binding site [chemical binding]; other site 889932006809 Q-loop/lid; other site 889932006810 ABC transporter signature motif; other site 889932006811 Walker B; other site 889932006812 D-loop; other site 889932006813 H-loop/switch region; other site 889932006814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932006815 non-specific DNA binding site [nucleotide binding]; other site 889932006816 salt bridge; other site 889932006817 sequence-specific DNA binding site [nucleotide binding]; other site 889932006818 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 889932006819 Sulfatase; Region: Sulfatase; cl10460 889932006820 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 889932006821 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006822 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 889932006823 substrate binding pocket [chemical binding]; other site 889932006824 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 889932006825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932006826 DNA-binding site [nucleotide binding]; DNA binding site 889932006827 UTRA domain; Region: UTRA; cl01230 889932006828 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 889932006829 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932006830 HPr interaction site; other site 889932006831 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932006832 active site 889932006833 phosphorylation site [posttranslational modification] 889932006834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 889932006835 metal binding site [ion binding]; metal-binding site 889932006836 active site 889932006837 I-site; other site 889932006838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 889932006839 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 889932006840 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 889932006841 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 889932006842 Class III ribonucleotide reductase; Region: RNR_III; cd01675 889932006843 effector binding site; other site 889932006844 active site 889932006845 Zn binding site [ion binding]; other site 889932006846 glycine loop; other site 889932006847 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 889932006848 active site 889932006849 catalytic residues [active] 889932006850 metal binding site [ion binding]; metal-binding site 889932006851 ApbE family; Region: ApbE; cl00643 889932006852 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 889932006853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 889932006854 FMN binding site [chemical binding]; other site 889932006855 active site 889932006856 catalytic residues [active] 889932006857 substrate binding site [chemical binding]; other site 889932006858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932006859 Helix-turn-helix domains; Region: HTH; cl00088 889932006860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932006861 dimerization interface [polypeptide binding]; other site 889932006862 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 889932006863 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932006864 transmembrane helices; other site 889932006865 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 889932006866 Predicted membrane protein [Function unknown]; Region: COG4640 889932006867 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 889932006868 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 889932006869 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932006870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932006871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 889932006872 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932006873 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 889932006874 Collagen binding domain; Region: Collagen_bind; pfam05737 889932006875 EamA-like transporter family; Region: EamA; cl01037 889932006876 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932006877 EamA-like transporter family; Region: EamA; cl01037 889932006878 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 889932006879 catalytic triad [active] 889932006880 catalytic triad [active] 889932006881 oxyanion hole [active] 889932006882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889932006883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932006884 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 889932006885 Helix-turn-helix domains; Region: HTH; cl00088 889932006886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932006887 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932006888 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932006889 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932006890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006891 Walker A/P-loop; other site 889932006892 ATP binding site [chemical binding]; other site 889932006893 Q-loop/lid; other site 889932006894 ABC transporter signature motif; other site 889932006895 Walker B; other site 889932006896 D-loop; other site 889932006897 H-loop/switch region; other site 889932006898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932006899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932006900 putative DNA binding site [nucleotide binding]; other site 889932006901 putative Zn2+ binding site [ion binding]; other site 889932006902 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 889932006903 dimer interface [polypeptide binding]; other site 889932006904 FMN binding site [chemical binding]; other site 889932006905 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 889932006906 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932006907 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932006908 active site turn [active] 889932006909 phosphorylation site [posttranslational modification] 889932006910 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932006911 HPr interaction site; other site 889932006912 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932006913 active site 889932006914 phosphorylation site [posttranslational modification] 889932006915 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 889932006916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932006917 Walker A/P-loop; other site 889932006918 ATP binding site [chemical binding]; other site 889932006919 Q-loop/lid; other site 889932006920 ABC transporter signature motif; other site 889932006921 Walker B; other site 889932006922 D-loop; other site 889932006923 H-loop/switch region; other site 889932006924 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 889932006925 TM-ABC transporter signature motif; other site 889932006926 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 889932006927 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 889932006928 zinc binding site [ion binding]; other site 889932006929 putative ligand binding site [chemical binding]; other site 889932006930 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932006931 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932006932 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932006933 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932006934 FOG: CBS domain [General function prediction only]; Region: COG0517 889932006935 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 889932006936 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 889932006937 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 889932006938 Walker A/P-loop; other site 889932006939 ATP binding site [chemical binding]; other site 889932006940 Q-loop/lid; other site 889932006941 ABC transporter signature motif; other site 889932006942 Walker B; other site 889932006943 D-loop; other site 889932006944 H-loop/switch region; other site 889932006945 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 889932006946 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 889932006947 Walker A/P-loop; other site 889932006948 ATP binding site [chemical binding]; other site 889932006949 Q-loop/lid; other site 889932006950 ABC transporter signature motif; other site 889932006951 Walker B; other site 889932006952 D-loop; other site 889932006953 H-loop/switch region; other site 889932006954 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 889932006955 TM-ABC transporter signature motif; other site 889932006956 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 889932006957 TM-ABC transporter signature motif; other site 889932006958 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 889932006959 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 889932006960 putative ligand binding site [chemical binding]; other site 889932006961 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 889932006962 active site 889932006963 GtrA-like protein; Region: GtrA; cl00971 889932006964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932006965 non-specific DNA binding site [nucleotide binding]; other site 889932006966 salt bridge; other site 889932006967 sequence-specific DNA binding site [nucleotide binding]; other site 889932006968 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 889932006969 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 889932006970 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932006971 Ligand Binding Site [chemical binding]; other site 889932006972 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 889932006973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932006974 dimerization interface [polypeptide binding]; other site 889932006975 putative DNA binding site [nucleotide binding]; other site 889932006976 putative Zn2+ binding site [ion binding]; other site 889932006977 Cadmium resistance transporter; Region: Cad; cl04177 889932006978 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 889932006979 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 889932006980 Herpes virus major outer envelope glycoprotein (BLLF1); Region: Herpes_BLLF1; pfam05109 889932006981 Gram positive anchor; Region: Gram_pos_anchor; cl15427 889932006982 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 889932006983 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932006984 active site 889932006985 metal binding site [ion binding]; metal-binding site 889932006986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932006987 non-specific DNA binding site [nucleotide binding]; other site 889932006988 salt bridge; other site 889932006989 sequence-specific DNA binding site [nucleotide binding]; other site 889932006990 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932006991 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932006992 HPr interaction site; other site 889932006993 active site 889932006994 phosphorylation site [posttranslational modification] 889932006995 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 889932006996 active site 889932006997 P-loop; other site 889932006998 phosphorylation site [posttranslational modification] 889932006999 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932007000 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007001 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932007002 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 889932007003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889932007004 NADP binding site [chemical binding]; other site 889932007005 putative substrate binding site [chemical binding]; other site 889932007006 active site 889932007007 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932007008 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932007009 DNA binding residues [nucleotide binding] 889932007010 putative dimer interface [polypeptide binding]; other site 889932007011 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932007012 putative peptidoglycan binding site; other site 889932007013 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932007014 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932007015 putative peptidoglycan binding site; other site 889932007016 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 889932007017 SdpI/YhfL protein family; Region: SdpI; pfam13630 889932007018 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 889932007019 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889932007020 intersubunit interface [polypeptide binding]; other site 889932007021 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 889932007022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 889932007023 metal binding site [ion binding]; metal-binding site 889932007024 active site 889932007025 I-site; other site 889932007026 DNA polymerase IV; Reviewed; Region: PRK03103 889932007027 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 889932007028 active site 889932007029 DNA binding site [nucleotide binding] 889932007030 Helix-turn-helix domains; Region: HTH; cl00088 889932007031 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 889932007032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 889932007033 dimerization interface [polypeptide binding]; other site 889932007034 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889932007035 classical (c) SDRs; Region: SDR_c; cd05233 889932007036 NAD(P) binding site [chemical binding]; other site 889932007037 active site 889932007038 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 889932007039 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932007040 putative NAD(P) binding site [chemical binding]; other site 889932007041 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 889932007042 substrate binding site [chemical binding]; other site 889932007043 Cupin domain; Region: Cupin_2; cl09118 889932007044 Cyclophilin-like; Region: Cyclophil_like; cl00950 889932007045 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 889932007046 classical (c) SDRs; Region: SDR_c; cd05233 889932007047 NAD(P) binding site [chemical binding]; other site 889932007048 active site 889932007049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007050 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932007051 NAD(P) binding site [chemical binding]; other site 889932007052 active site 889932007053 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 889932007054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932007055 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932007056 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 889932007057 Walker A/P-loop; other site 889932007058 ATP binding site [chemical binding]; other site 889932007059 Q-loop/lid; other site 889932007060 ABC transporter signature motif; other site 889932007061 Walker B; other site 889932007062 D-loop; other site 889932007063 H-loop/switch region; other site 889932007064 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932007065 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932007066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 889932007067 Walker A/P-loop; other site 889932007068 ATP binding site [chemical binding]; other site 889932007069 Q-loop/lid; other site 889932007070 ABC transporter signature motif; other site 889932007071 Walker B; other site 889932007072 D-loop; other site 889932007073 H-loop/switch region; other site 889932007074 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 889932007075 active site 889932007076 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 889932007077 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 889932007078 metal binding site [ion binding]; metal-binding site 889932007079 dimer interface [polypeptide binding]; other site 889932007080 oxidoreductase; Provisional; Region: PRK06128 889932007081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007082 NAD(P) binding site [chemical binding]; other site 889932007083 active site 889932007084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932007085 non-specific DNA binding site [nucleotide binding]; other site 889932007086 salt bridge; other site 889932007087 sequence-specific DNA binding site [nucleotide binding]; other site 889932007088 inner membrane transporter YjeM; Provisional; Region: PRK15238 889932007089 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 889932007090 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 889932007091 dimer interface [polypeptide binding]; other site 889932007092 active site 889932007093 metal binding site [ion binding]; metal-binding site 889932007094 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 889932007095 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 889932007096 catalytic Zn binding site [ion binding]; other site 889932007097 NAD binding site [chemical binding]; other site 889932007098 structural Zn binding site [ion binding]; other site 889932007099 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 889932007100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932007101 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932007102 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 889932007103 MucBP domain; Region: MucBP; pfam06458 889932007104 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 889932007105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932007106 TfoX N-terminal domain; Region: TfoX_N; cl01167 889932007107 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932007108 Helix-turn-helix domains; Region: HTH; cl00088 889932007109 Integrase core domain; Region: rve; cl01316 889932007110 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007111 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932007112 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932007113 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007114 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 889932007115 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 889932007116 NAD(P) binding site [chemical binding]; other site 889932007117 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 889932007118 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932007119 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932007120 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007121 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932007122 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007123 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007124 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932007125 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007126 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007127 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007128 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007129 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932007130 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007131 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007132 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007133 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007134 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 889932007135 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932007136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932007137 motif II; other site 889932007138 Helix-turn-helix domains; Region: HTH; cl00088 889932007139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 889932007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007141 putative substrate translocation pore; other site 889932007142 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889932007143 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 889932007144 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 889932007145 active site 889932007146 dimer interface [polypeptide binding]; other site 889932007147 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 889932007148 Ligand Binding Site [chemical binding]; other site 889932007149 Molecular Tunnel; other site 889932007150 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932007151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932007152 active site 889932007153 phosphorylation site [posttranslational modification] 889932007154 intermolecular recognition site; other site 889932007155 dimerization interface [polypeptide binding]; other site 889932007156 LytTr DNA-binding domain; Region: LytTR; cl04498 889932007157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007158 Helix-turn-helix domains; Region: HTH; cl00088 889932007159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007160 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932007161 NAD(P) binding site [chemical binding]; other site 889932007162 active site 889932007163 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 889932007164 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 889932007165 NAD(P) binding site [chemical binding]; other site 889932007166 catalytic residues [active] 889932007167 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889932007168 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889932007169 active site 889932007170 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007171 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007172 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007173 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007174 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007175 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 889932007176 Helix-turn-helix domains; Region: HTH; cl00088 889932007177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932007178 Helix-turn-helix domains; Region: HTH; cl00088 889932007179 Integrase core domain; Region: rve; cl01316 889932007180 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 889932007181 classical (c) SDRs; Region: SDR_c; cd05233 889932007182 NAD(P) binding site [chemical binding]; other site 889932007183 active site 889932007184 Helix-turn-helix domains; Region: HTH; cl00088 889932007185 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 889932007186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889932007187 NADP binding site [chemical binding]; other site 889932007188 putative substrate binding site [chemical binding]; other site 889932007189 active site 889932007190 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 889932007191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932007192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932007193 active site 889932007194 catalytic tetrad [active] 889932007195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932007197 putative substrate translocation pore; other site 889932007198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007200 Helix-turn-helix domains; Region: HTH; cl00088 889932007201 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 889932007202 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 889932007203 intersubunit interface [polypeptide binding]; other site 889932007204 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 889932007205 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 889932007206 Walker A/P-loop; other site 889932007207 ATP binding site [chemical binding]; other site 889932007208 Q-loop/lid; other site 889932007209 ABC transporter signature motif; other site 889932007210 Walker B; other site 889932007211 D-loop; other site 889932007212 H-loop/switch region; other site 889932007213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889932007214 ABC-ATPase subunit interface; other site 889932007215 dimer interface [polypeptide binding]; other site 889932007216 putative PBP binding regions; other site 889932007217 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 889932007218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 889932007219 ABC-ATPase subunit interface; other site 889932007220 dimer interface [polypeptide binding]; other site 889932007221 putative PBP binding regions; other site 889932007222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007223 Helix-turn-helix domains; Region: HTH; cl00088 889932007224 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 889932007225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 889932007226 putative NAD(P) binding site [chemical binding]; other site 889932007227 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 889932007228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007229 NAD(P) binding site [chemical binding]; other site 889932007230 active site 889932007231 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 889932007232 putative trimer interface [polypeptide binding]; other site 889932007233 putative CoA binding site [chemical binding]; other site 889932007234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007235 NAD(P) binding site [chemical binding]; other site 889932007236 active site 889932007237 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932007238 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 889932007239 DNA binding residues [nucleotide binding] 889932007240 MucBP domain; Region: MucBP; pfam06458 889932007241 MucBP domain; Region: MucBP; pfam06458 889932007242 MucBP domain; Region: MucBP; pfam06458 889932007243 MucBP domain; Region: MucBP; pfam06458 889932007244 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932007245 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932007246 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932007247 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007248 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007249 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007250 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932007251 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007252 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007253 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007254 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007255 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932007256 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007257 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007259 Helix-turn-helix domains; Region: HTH; cl00088 889932007260 GTP-binding protein LepA; Provisional; Region: PRK05433 889932007261 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 889932007262 G1 box; other site 889932007263 putative GEF interaction site [polypeptide binding]; other site 889932007264 GTP/Mg2+ binding site [chemical binding]; other site 889932007265 Switch I region; other site 889932007266 G2 box; other site 889932007267 G3 box; other site 889932007268 Switch II region; other site 889932007269 G4 box; other site 889932007270 G5 box; other site 889932007271 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 889932007272 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 889932007273 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 889932007274 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932007275 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932007276 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 889932007277 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 889932007278 putative NADH binding site [chemical binding]; other site 889932007279 putative active site [active] 889932007280 nudix motif; other site 889932007281 putative metal binding site [ion binding]; other site 889932007282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932007283 Helix-turn-helix domains; Region: HTH; cl00088 889932007284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932007285 dimerization interface [polypeptide binding]; other site 889932007286 hypothetical protein; Validated; Region: PRK07121 889932007287 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 889932007288 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007289 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007290 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007291 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007292 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 889932007293 Ferritin-like domain; Region: Ferritin; pfam00210 889932007294 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 889932007295 dimerization interface [polypeptide binding]; other site 889932007296 DPS ferroxidase diiron center [ion binding]; other site 889932007297 ion pore; other site 889932007298 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932007299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932007300 DNA-binding site [nucleotide binding]; DNA binding site 889932007301 UTRA domain; Region: UTRA; cl01230 889932007302 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932007303 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932007304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007305 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 889932007306 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 889932007307 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 889932007308 DNA binding residues [nucleotide binding] 889932007309 putative dimer interface [polypeptide binding]; other site 889932007310 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 889932007311 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 889932007312 Protein of unknown function (DUF805); Region: DUF805; cl01224 889932007313 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 889932007314 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 889932007315 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 889932007316 conserved cys residue [active] 889932007317 Helix-turn-helix domains; Region: HTH; cl00088 889932007318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 889932007319 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 889932007320 Walker A/P-loop; other site 889932007321 ATP binding site [chemical binding]; other site 889932007322 Q-loop/lid; other site 889932007323 ABC transporter signature motif; other site 889932007324 Walker B; other site 889932007325 D-loop; other site 889932007326 H-loop/switch region; other site 889932007327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932007328 non-specific DNA binding site [nucleotide binding]; other site 889932007329 salt bridge; other site 889932007330 sequence-specific DNA binding site [nucleotide binding]; other site 889932007331 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 889932007332 Bacterial SH3 domain; Region: SH3_3; cl02551 889932007333 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 889932007334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932007335 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932007336 active site 889932007337 catalytic tetrad [active] 889932007338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007339 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932007340 NAD(P) binding site [chemical binding]; other site 889932007341 active site 889932007342 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 889932007343 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932007344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007345 putative substrate translocation pore; other site 889932007346 Helix-turn-helix domains; Region: HTH; cl00088 889932007347 Helix-turn-helix domains; Region: HTH; cl00088 889932007348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932007349 catalytic core [active] 889932007350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 889932007351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 889932007352 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889932007353 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932007354 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932007355 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 889932007356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932007357 S-adenosylmethionine binding site [chemical binding]; other site 889932007358 Catalytic domain of Protein Kinases; Region: PKc; cd00180 889932007359 active site 889932007360 ATP binding site [chemical binding]; other site 889932007361 substrate binding site [chemical binding]; other site 889932007362 activation loop (A-loop); other site 889932007363 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 889932007364 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 889932007365 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 889932007366 AzlC protein; Region: AzlC; cl00570 889932007367 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 889932007368 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932007369 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 889932007370 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932007371 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 889932007372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 889932007373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932007374 dimer interface [polypeptide binding]; other site 889932007375 phosphorylation site [posttranslational modification] 889932007376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932007377 ATP binding site [chemical binding]; other site 889932007378 Mg2+ binding site [ion binding]; other site 889932007379 G-X-G motif; other site 889932007380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932007381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932007382 active site 889932007383 phosphorylation site [posttranslational modification] 889932007384 intermolecular recognition site; other site 889932007385 dimerization interface [polypeptide binding]; other site 889932007386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932007387 DNA binding site [nucleotide binding] 889932007388 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 889932007389 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 889932007390 PPIC-type PPIASE domain; Region: Rotamase; cl08278 889932007391 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 889932007392 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 889932007393 active site 889932007394 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 889932007395 GTP-binding protein YchF; Reviewed; Region: PRK09601 889932007396 YchF GTPase; Region: YchF; cd01900 889932007397 G1 box; other site 889932007398 GTP/Mg2+ binding site [chemical binding]; other site 889932007399 Switch I region; other site 889932007400 G2 box; other site 889932007401 Switch II region; other site 889932007402 G3 box; other site 889932007403 G4 box; other site 889932007404 G5 box; other site 889932007405 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 889932007406 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 889932007407 ParB-like partition proteins; Region: parB_part; TIGR00180 889932007408 ParB-like nuclease domain; Region: ParBc; cl02129 889932007409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932007410 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 889932007411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889932007412 P-loop; other site 889932007413 Magnesium ion binding site [ion binding]; other site 889932007414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889932007415 ParB-like partition proteins; Region: parB_part; TIGR00180 889932007416 ParB-like nuclease domain; Region: ParBc; cl02129 889932007417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 889932007418 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 889932007419 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 889932007420 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 889932007421 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 889932007422 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932007424 Helix-turn-helix domains; Region: HTH; cl00088 889932007425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 889932007426 dimerization interface [polypeptide binding]; other site 889932007427 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 889932007428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 889932007429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932007430 homodimer interface [polypeptide binding]; other site 889932007431 catalytic residue [active] 889932007432 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932007433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932007434 substrate binding pocket [chemical binding]; other site 889932007435 membrane-bound complex binding site; other site 889932007436 hinge residues; other site 889932007437 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 889932007438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932007439 dimer interface [polypeptide binding]; other site 889932007440 conserved gate region; other site 889932007441 putative PBP binding loops; other site 889932007442 ABC-ATPase subunit interface; other site 889932007443 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 889932007444 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 889932007445 Walker A/P-loop; other site 889932007446 ATP binding site [chemical binding]; other site 889932007447 Q-loop/lid; other site 889932007448 ABC transporter signature motif; other site 889932007449 Walker B; other site 889932007450 D-loop; other site 889932007451 H-loop/switch region; other site 889932007452 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 889932007453 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 889932007454 substrate binding pocket [chemical binding]; other site 889932007455 membrane-bound complex binding site; other site 889932007456 hinge residues; other site 889932007457 Helix-turn-helix domains; Region: HTH; cl00088 889932007458 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 889932007459 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 889932007460 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 889932007461 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932007462 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932007463 active site turn [active] 889932007464 phosphorylation site [posttranslational modification] 889932007465 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007466 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932007467 HPr interaction site; other site 889932007468 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932007469 active site 889932007470 phosphorylation site [posttranslational modification] 889932007471 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932007472 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932007473 Ca binding site [ion binding]; other site 889932007474 active site 889932007475 catalytic site [active] 889932007476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932007477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932007478 DNA binding site [nucleotide binding] 889932007479 domain linker motif; other site 889932007480 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 889932007481 putative dimerization interface [polypeptide binding]; other site 889932007482 putative ligand binding site [chemical binding]; other site 889932007483 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889932007484 putative active site [active] 889932007485 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 889932007486 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 889932007487 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 889932007488 Walker A/P-loop; other site 889932007489 ATP binding site [chemical binding]; other site 889932007490 Q-loop/lid; other site 889932007491 ABC transporter signature motif; other site 889932007492 Walker B; other site 889932007493 D-loop; other site 889932007494 H-loop/switch region; other site 889932007495 TRAM domain; Region: TRAM; cl01282 889932007496 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 889932007497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 889932007498 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 889932007499 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 889932007500 NADP binding site [chemical binding]; other site 889932007501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932007502 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 889932007503 active site 889932007504 motif I; other site 889932007505 motif II; other site 889932007506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932007507 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932007508 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932007509 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 889932007510 alpha-mannosidase; Provisional; Region: PRK09819 889932007511 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 889932007512 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007513 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 889932007514 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 889932007515 active site 889932007516 P-loop; other site 889932007517 phosphorylation site [posttranslational modification] 889932007518 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932007519 active site 889932007520 phosphorylation site [posttranslational modification] 889932007521 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889932007522 Helix-turn-helix domains; Region: HTH; cl00088 889932007523 PRD domain; Region: PRD; cl15445 889932007524 PRD domain; Region: PRD; cl15445 889932007525 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889932007526 active site 889932007527 P-loop; other site 889932007528 phosphorylation site [posttranslational modification] 889932007529 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932007530 active site 889932007531 phosphorylation site [posttranslational modification] 889932007532 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 889932007533 DNA binding residues [nucleotide binding] 889932007534 putative dimer interface [polypeptide binding]; other site 889932007535 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 889932007536 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 889932007537 NADP binding site [chemical binding]; other site 889932007538 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932007539 HPr interaction site; other site 889932007540 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932007541 active site 889932007542 phosphorylation site [posttranslational modification] 889932007543 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 889932007544 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932007545 active site turn [active] 889932007546 phosphorylation site [posttranslational modification] 889932007547 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007548 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889932007549 endonuclease III; Region: ENDO3c; smart00478 889932007550 minor groove reading motif; other site 889932007551 helix-hairpin-helix signature motif; other site 889932007552 substrate binding pocket [chemical binding]; other site 889932007553 active site 889932007554 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 889932007555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 889932007556 metal binding site 2 [ion binding]; metal-binding site 889932007557 putative DNA binding helix; other site 889932007558 metal binding site 1 [ion binding]; metal-binding site 889932007559 dimer interface [polypeptide binding]; other site 889932007560 structural Zn2+ binding site [ion binding]; other site 889932007561 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932007562 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 889932007563 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 889932007564 active site 889932007565 metal binding site [ion binding]; metal-binding site 889932007566 hexamer interface [polypeptide binding]; other site 889932007567 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 889932007568 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932007569 LrgA family; Region: LrgA; cl00608 889932007570 LrgB-like family; Region: LrgB; cl00596 889932007571 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932007572 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 889932007573 phytoene desaturase; Region: crtI_fam; TIGR02734 889932007574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007575 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 889932007576 active site lid residues [active] 889932007577 substrate binding pocket [chemical binding]; other site 889932007578 catalytic residues [active] 889932007579 substrate-Mg2+ binding site; other site 889932007580 aspartate-rich region 1; other site 889932007581 aspartate-rich region 2; other site 889932007582 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007583 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889932007584 Glycerate kinase family; Region: Gly_kinase; cl00841 889932007585 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 889932007586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932007587 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932007588 Enterocin A Immunity; Region: EntA_Immun; pfam08951 889932007589 adenylosuccinate lyase; Provisional; Region: PRK07492 889932007590 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 889932007591 tetramer interface [polypeptide binding]; other site 889932007592 active site 889932007593 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 889932007594 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 889932007595 GDP-binding site [chemical binding]; other site 889932007596 ACT binding site; other site 889932007597 IMP binding site; other site 889932007598 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 889932007599 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 889932007600 active site 889932007601 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 889932007602 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 889932007603 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 889932007604 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 889932007605 PLD-like domain; Region: PLDc_2; pfam13091 889932007606 putative active site [active] 889932007607 catalytic site [active] 889932007608 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 889932007609 PLD-like domain; Region: PLDc_2; pfam13091 889932007610 putative active site [active] 889932007611 catalytic site [active] 889932007612 amino acid transporter; Region: 2A0306; TIGR00909 889932007613 Spore germination protein; Region: Spore_permease; cl15802 889932007614 Spore germination protein; Region: Spore_permease; cl15802 889932007615 K+ potassium transporter; Region: K_trans; cl15781 889932007616 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 889932007617 Cation efflux family; Region: Cation_efflux; cl00316 889932007618 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 889932007619 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 889932007620 substrate binding site [chemical binding]; other site 889932007621 THF binding site; other site 889932007622 zinc-binding site [ion binding]; other site 889932007623 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 889932007624 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 889932007625 Haemolysin-III related; Region: HlyIII; cl03831 889932007626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 889932007627 dimerization interface [polypeptide binding]; other site 889932007628 putative DNA binding site [nucleotide binding]; other site 889932007629 putative Zn2+ binding site [ion binding]; other site 889932007630 Cation efflux family; Region: Cation_efflux; cl00316 889932007631 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 889932007632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932007633 non-specific DNA binding site [nucleotide binding]; other site 889932007634 salt bridge; other site 889932007635 sequence-specific DNA binding site [nucleotide binding]; other site 889932007636 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 889932007637 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 889932007638 dihydropteroate synthase; Region: DHPS; TIGR01496 889932007639 substrate binding pocket [chemical binding]; other site 889932007640 dimer interface [polypeptide binding]; other site 889932007641 inhibitor binding site; inhibition site 889932007642 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 889932007643 active site 889932007644 dimerization interface [polypeptide binding]; other site 889932007645 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 889932007646 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 889932007647 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 889932007648 GTP cyclohydrolase I; Provisional; Region: PLN03044 889932007649 active site 889932007650 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 889932007651 catalytic center binding site [active] 889932007652 ATP binding site [chemical binding]; other site 889932007653 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 889932007654 homooctamer interface [polypeptide binding]; other site 889932007655 active site 889932007656 Colicin V production protein; Region: Colicin_V; cl00567 889932007657 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 889932007658 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 889932007659 metal binding site [ion binding]; metal-binding site 889932007660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007661 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932007662 putative substrate translocation pore; other site 889932007663 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 889932007664 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 889932007665 Pyruvate formate lyase 1; Region: PFL1; cd01678 889932007666 coenzyme A binding site [chemical binding]; other site 889932007667 active site 889932007668 catalytic residues [active] 889932007669 glycine loop; other site 889932007670 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 889932007671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 889932007672 FeS/SAM binding site; other site 889932007673 Domain of unknown function DUF59; Region: DUF59; cl00941 889932007674 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932007675 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932007676 active site 889932007677 catalytic tetrad [active] 889932007678 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 889932007679 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 889932007680 active site 889932007681 catalytic triad [active] 889932007682 oxyanion hole [active] 889932007683 BCCT family transporter; Region: BCCT; cl00569 889932007684 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 889932007685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932007686 Protein of unknown function (DUF419); Region: DUF419; cl15265 889932007687 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 889932007688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889932007689 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 889932007690 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 889932007691 active site 889932007692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889932007693 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 889932007694 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 889932007695 dimer interface [polypeptide binding]; other site 889932007696 active site 889932007697 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 889932007698 Transposase domain (DUF772); Region: DUF772; cl15789 889932007699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 889932007700 Transposase domain (DUF772); Region: DUF772; cl15789 889932007701 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 889932007702 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 889932007703 Spore germination protein; Region: Spore_permease; cl15802 889932007704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007705 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 889932007706 tetramer interfaces [polypeptide binding]; other site 889932007707 binuclear metal-binding site [ion binding]; other site 889932007708 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 889932007709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007710 NAD(P) binding site [chemical binding]; other site 889932007711 active site 889932007712 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932007713 Helix-turn-helix domains; Region: HTH; cl00088 889932007714 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889932007715 ArsC family; Region: ArsC; pfam03960 889932007716 putative catalytic residues [active] 889932007717 thiol/disulfide switch; other site 889932007718 Protein of unknown function, DUF488; Region: DUF488; cl01246 889932007719 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 889932007720 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 889932007721 minor groove reading motif; other site 889932007722 helix-hairpin-helix signature motif; other site 889932007723 substrate binding pocket [chemical binding]; other site 889932007724 active site 889932007725 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 889932007726 DNA binding and oxoG recognition site [nucleotide binding] 889932007727 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 889932007728 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 889932007729 putative dimer interface [polypeptide binding]; other site 889932007730 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 889932007731 NADH(P)-binding; Region: NAD_binding_10; pfam13460 889932007732 putative NAD(P) binding site [chemical binding]; other site 889932007733 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 889932007734 EamA-like transporter family; Region: EamA; cl01037 889932007735 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 889932007736 EamA-like transporter family; Region: EamA; cl01037 889932007737 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 889932007738 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 889932007739 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 889932007740 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 889932007741 active site 889932007742 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 889932007743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932007744 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932007745 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 889932007746 Helix-turn-helix domains; Region: HTH; cl00088 889932007747 zinc-finger; Region: zf-RING_3; pfam14369 889932007748 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 889932007749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007750 putative substrate translocation pore; other site 889932007751 Sodium:solute symporter family; Region: SSF; cl00456 889932007752 drug efflux system protein MdtG; Provisional; Region: PRK09874 889932007753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007754 putative substrate translocation pore; other site 889932007755 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889932007756 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007757 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 889932007758 TIR domain; Region: TIR_2; cl15770 889932007759 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 889932007760 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 889932007761 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932007762 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 889932007763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932007764 active site 889932007765 motif I; other site 889932007766 motif II; other site 889932007767 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 889932007768 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 889932007769 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 889932007770 active site 889932007771 metal binding site [ion binding]; metal-binding site 889932007772 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 889932007773 Membrane transport protein; Region: Mem_trans; cl09117 889932007774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932007775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 889932007776 active site 889932007777 catalytic tetrad [active] 889932007778 Uncharacterized conserved protein [Function unknown]; Region: COG2966 889932007779 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932007780 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 889932007781 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 889932007782 Bacitracin resistance protein BacA; Region: BacA; cl00858 889932007783 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 889932007784 putative ADP-ribose binding site [chemical binding]; other site 889932007785 putative active site [active] 889932007786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007787 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 889932007788 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007789 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932007790 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932007791 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007792 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 889932007793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932007794 Helix-turn-helix domains; Region: HTH; cl00088 889932007795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007796 Helix-turn-helix domains; Region: HTH; cl00088 889932007797 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 889932007798 active site 889932007799 metal-binding site [ion binding] 889932007800 nucleotide-binding site [chemical binding]; other site 889932007801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932007802 non-specific DNA binding site [nucleotide binding]; other site 889932007803 salt bridge; other site 889932007804 sequence-specific DNA binding site [nucleotide binding]; other site 889932007805 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 889932007806 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 889932007807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 889932007808 catalytic residue [active] 889932007809 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932007810 putative peptidoglycan binding site; other site 889932007811 NlpC/P60 family; Region: NLPC_P60; cl11438 889932007812 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 889932007813 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 889932007814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 889932007815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007816 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 889932007817 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 889932007818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 889932007819 S-adenosylmethionine binding site [chemical binding]; other site 889932007820 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 889932007821 putative active site [active] 889932007822 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 889932007823 active site 889932007824 catalytic triad [active] 889932007825 oxyanion hole [active] 889932007826 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 889932007827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932007828 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932007829 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 889932007830 amphipathic channel; other site 889932007831 Asn-Pro-Ala signature motifs; other site 889932007832 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 889932007833 catalytic residues [active] 889932007834 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 889932007835 putative homodimer interface [polypeptide binding]; other site 889932007836 putative homotetramer interface [polypeptide binding]; other site 889932007837 putative metal binding site [ion binding]; other site 889932007838 putative homodimer-homodimer interface [polypeptide binding]; other site 889932007839 putative allosteric switch controlling residues; other site 889932007840 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 889932007841 Ferritin-like domain; Region: Ferritin; pfam00210 889932007842 dimerization interface [polypeptide binding]; other site 889932007843 DPS ferroxidase diiron center [ion binding]; other site 889932007844 ion pore; other site 889932007845 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 889932007846 metal-binding site [ion binding] 889932007847 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 889932007848 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 889932007849 ligand binding site [chemical binding]; other site 889932007850 flexible hinge region; other site 889932007851 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 889932007852 putative switch regulator; other site 889932007853 non-specific DNA interactions [nucleotide binding]; other site 889932007854 DNA binding site [nucleotide binding] 889932007855 sequence specific DNA binding site [nucleotide binding]; other site 889932007856 putative cAMP binding site [chemical binding]; other site 889932007857 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 889932007858 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 889932007859 active site 889932007860 Zn binding site [ion binding]; other site 889932007861 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 889932007862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932007863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 889932007864 legume lectins; Region: lectin_L-type; cl14058 889932007865 homotetramer interaction site [polypeptide binding]; other site 889932007866 carbohydrate binding site [chemical binding]; other site 889932007867 metal binding site [ion binding]; metal-binding site 889932007868 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007869 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932007870 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932007871 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007872 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932007873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 889932007874 Helix-turn-helix domains; Region: HTH; cl00088 889932007875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 889932007876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932007877 Walker A motif; other site 889932007878 ATP binding site [chemical binding]; other site 889932007879 Walker B motif; other site 889932007880 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 889932007881 amphipathic channel; other site 889932007882 Asn-Pro-Ala signature motifs; other site 889932007883 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 889932007884 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 889932007885 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 889932007886 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 889932007887 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 889932007888 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932007889 HPr interaction site; other site 889932007890 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932007891 active site 889932007892 phosphorylation site [posttranslational modification] 889932007893 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 889932007894 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 889932007895 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 889932007896 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 889932007897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932007898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932007899 DNA binding site [nucleotide binding] 889932007900 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 889932007901 putative dimerization interface [polypeptide binding]; other site 889932007902 putative ligand binding site [chemical binding]; other site 889932007903 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 889932007904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932007905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007906 putative substrate translocation pore; other site 889932007907 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 889932007908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007909 putative substrate translocation pore; other site 889932007910 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932007911 Cupin domain; Region: Cupin_2; cl09118 889932007912 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889932007913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932007914 Fic/DOC family; Region: Fic; cl00960 889932007915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 889932007916 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 889932007917 putative dimerization interface [polypeptide binding]; other site 889932007918 putative ligand binding site [chemical binding]; other site 889932007919 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 889932007920 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889932007921 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 889932007922 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 889932007923 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 889932007924 NAD binding site [chemical binding]; other site 889932007925 homodimer interface [polypeptide binding]; other site 889932007926 active site 889932007927 substrate binding site [chemical binding]; other site 889932007928 galactokinase; Provisional; Region: PRK05322 889932007929 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 889932007930 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 889932007931 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 889932007932 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 889932007933 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 889932007934 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 889932007935 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 889932007936 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 889932007937 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 889932007938 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 889932007939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007940 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 889932007941 HPr interaction site; other site 889932007942 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932007943 active site 889932007944 phosphorylation site [posttranslational modification] 889932007945 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 889932007946 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 889932007947 active site 889932007948 catalytic residues [active] 889932007949 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 889932007950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932007951 DNA binding site [nucleotide binding] 889932007952 domain linker motif; other site 889932007953 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 889932007954 putative dimerization interface [polypeptide binding]; other site 889932007955 putative ligand binding site [chemical binding]; other site 889932007956 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 889932007957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 889932007958 active site 889932007959 catalytic tetrad [active] 889932007960 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 889932007961 FMN-binding domain; Region: FMN_bind; cl01081 889932007962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932007963 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 889932007964 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932007965 ApbE family; Region: ApbE; cl00643 889932007966 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 889932007967 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 889932007968 active site 889932007969 catalytic residue [active] 889932007970 dimer interface [polypeptide binding]; other site 889932007971 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 889932007972 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 889932007973 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 889932007974 shikimate binding site; other site 889932007975 NAD(P) binding site [chemical binding]; other site 889932007976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 889932007977 Helix-turn-helix domains; Region: HTH; cl00088 889932007978 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 889932007979 putative dimerization interface [polypeptide binding]; other site 889932007980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932007981 putative substrate translocation pore; other site 889932007982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932007983 Putative esterase; Region: Esterase; pfam00756 889932007984 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932007986 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 889932007987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932007988 DNA-binding site [nucleotide binding]; DNA binding site 889932007989 UTRA domain; Region: UTRA; cl01230 889932007990 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 889932007991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932007992 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 889932007993 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 889932007994 putative active site [active] 889932007995 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932007996 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 889932007997 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932007998 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 889932007999 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932008000 active site turn [active] 889932008001 phosphorylation site [posttranslational modification] 889932008002 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932008003 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 889932008004 HPr interaction site; other site 889932008005 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932008006 active site 889932008007 phosphorylation site [posttranslational modification] 889932008008 transcriptional antiterminator BglG; Provisional; Region: PRK09772 889932008009 CAT RNA binding domain; Region: CAT_RBD; cl03904 889932008010 PRD domain; Region: PRD; cl15445 889932008011 PRD domain; Region: PRD; cl15445 889932008012 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932008013 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932008014 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 889932008015 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 889932008016 active site turn [active] 889932008017 phosphorylation site [posttranslational modification] 889932008018 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 889932008019 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 889932008020 HPr interaction site; other site 889932008021 glycerol kinase (GK) interaction site [polypeptide binding]; other site 889932008022 active site 889932008023 phosphorylation site [posttranslational modification] 889932008024 transcriptional antiterminator BglG; Provisional; Region: PRK09772 889932008025 CAT RNA binding domain; Region: CAT_RBD; cl03904 889932008026 PRD domain; Region: PRD; cl15445 889932008027 PRD domain; Region: PRD; cl15445 889932008028 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 889932008029 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 889932008030 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 889932008031 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 889932008032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932008033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932008034 DNA binding site [nucleotide binding] 889932008035 domain linker motif; other site 889932008036 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889932008037 dimerization interface [polypeptide binding]; other site 889932008038 ligand binding site [chemical binding]; other site 889932008039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932008040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932008041 putative substrate translocation pore; other site 889932008042 putative alpha-glucosidase; Provisional; Region: PRK10658 889932008043 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 889932008044 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 889932008045 trimer interface [polypeptide binding]; other site 889932008046 active site 889932008047 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 889932008048 catalytic site [active] 889932008049 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932008050 Helix-turn-helix domains; Region: HTH; cl00088 889932008051 Integrase core domain; Region: rve; cl01316 889932008052 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 889932008053 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 889932008054 active site 889932008055 sugar phosphate phosphatase; Provisional; Region: PRK10513 889932008056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932008057 active site 889932008058 motif I; other site 889932008059 motif II; other site 889932008060 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 889932008061 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 889932008062 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 889932008063 TPP-binding site [chemical binding]; other site 889932008064 dimer interface [polypeptide binding]; other site 889932008065 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 889932008066 PYR/PP interface [polypeptide binding]; other site 889932008067 dimer interface [polypeptide binding]; other site 889932008068 TPP binding site [chemical binding]; other site 889932008069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 889932008070 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 889932008071 active site 889932008072 intersubunit interactions; other site 889932008073 catalytic residue [active] 889932008074 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 889932008075 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 889932008076 active site 889932008077 P-loop; other site 889932008078 phosphorylation site [posttranslational modification] 889932008079 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932008080 active site 889932008081 phosphorylation site [posttranslational modification] 889932008082 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889932008083 PRD domain; Region: PRD; cl15445 889932008084 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 889932008085 active site 889932008086 P-loop; other site 889932008087 phosphorylation site [posttranslational modification] 889932008088 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932008089 active site 889932008090 phosphorylation site [posttranslational modification] 889932008091 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 889932008092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 889932008093 motif II; other site 889932008094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 889932008095 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 889932008096 putative NAD(P) binding site [chemical binding]; other site 889932008097 catalytic Zn binding site [ion binding]; other site 889932008098 structural Zn binding site [ion binding]; other site 889932008099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 889932008100 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 889932008101 active site 889932008102 P-loop; other site 889932008103 phosphorylation site [posttranslational modification] 889932008104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 889932008105 active site 889932008106 phosphorylation site [posttranslational modification] 889932008107 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889932008108 Helix-turn-helix domains; Region: HTH; cl00088 889932008109 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889932008110 putative phosphoketolase; Provisional; Region: PRK05261 889932008111 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 889932008112 TPP-binding site; other site 889932008113 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 889932008114 XFP C-terminal domain; Region: XFP_C; pfam09363 889932008115 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 889932008116 maltose O-acetyltransferase; Provisional; Region: PRK10092 889932008117 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 889932008118 active site 889932008119 substrate binding site [chemical binding]; other site 889932008120 trimer interface [polypeptide binding]; other site 889932008121 CoA binding site [chemical binding]; other site 889932008122 L-arabinose isomerase; Provisional; Region: PRK02929 889932008123 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 889932008124 hexamer (dimer of trimers) interface [polypeptide binding]; other site 889932008125 substrate binding site [chemical binding]; other site 889932008126 trimer interface [polypeptide binding]; other site 889932008127 Mn binding site [ion binding]; other site 889932008128 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 889932008129 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 889932008130 intersubunit interface [polypeptide binding]; other site 889932008131 active site 889932008132 Zn2+ binding site [ion binding]; other site 889932008133 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 889932008134 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 889932008135 putative N- and C-terminal domain interface [polypeptide binding]; other site 889932008136 putative active site [active] 889932008137 putative MgATP binding site [chemical binding]; other site 889932008138 catalytic site [active] 889932008139 metal binding site [ion binding]; metal-binding site 889932008140 putative carbohydrate binding site [chemical binding]; other site 889932008141 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 889932008142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932008143 putative substrate translocation pore; other site 889932008144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932008145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932008146 DNA-binding site [nucleotide binding]; DNA binding site 889932008147 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 889932008148 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 889932008149 putative dimerization interface [polypeptide binding]; other site 889932008150 putative ligand binding site [chemical binding]; other site 889932008151 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 889932008152 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 889932008153 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 889932008154 putative active site [active] 889932008155 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 889932008156 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 889932008157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932008158 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 889932008159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 889932008160 Sodium:solute symporter family; Region: SSF; cl00456 889932008161 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932008162 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932008163 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 889932008164 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932008165 N-acetylneuraminate lyase; Region: nanA; TIGR00683 889932008166 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 889932008167 inhibitor site; inhibition site 889932008168 active site 889932008169 dimer interface [polypeptide binding]; other site 889932008170 catalytic residue [active] 889932008171 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 889932008172 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 889932008173 putative active site cavity [active] 889932008174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 889932008175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 889932008176 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 889932008177 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 889932008178 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 889932008179 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 889932008180 ArsC family; Region: ArsC; pfam03960 889932008181 putative catalytic residues [active] 889932008182 thiol/disulfide switch; other site 889932008183 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 889932008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932008185 active site 889932008186 phosphorylation site [posttranslational modification] 889932008187 intermolecular recognition site; other site 889932008188 dimerization interface [polypeptide binding]; other site 889932008189 LytTr DNA-binding domain; Region: LytTR; cl04498 889932008190 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 889932008191 Accessory gene regulator B; Region: AgrB; cl01873 889932008192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932008193 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 889932008194 Walker A motif; other site 889932008195 ATP binding site [chemical binding]; other site 889932008196 Walker B motif; other site 889932008197 arginine finger; other site 889932008198 MoxR-like ATPases [General function prediction only]; Region: COG0714 889932008199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 889932008200 Walker A motif; other site 889932008201 ATP binding site [chemical binding]; other site 889932008202 Walker B motif; other site 889932008203 arginine finger; other site 889932008204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 889932008205 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 889932008206 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 889932008207 teramer interface [polypeptide binding]; other site 889932008208 active site 889932008209 FMN binding site [chemical binding]; other site 889932008210 catalytic residues [active] 889932008211 pyruvate oxidase; Provisional; Region: PRK08611 889932008212 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889932008213 PYR/PP interface [polypeptide binding]; other site 889932008214 dimer interface [polypeptide binding]; other site 889932008215 tetramer interface [polypeptide binding]; other site 889932008216 TPP binding site [chemical binding]; other site 889932008217 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932008218 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889932008219 TPP-binding site [chemical binding]; other site 889932008220 Predicted transcriptional regulator [Transcription]; Region: COG1959 889932008221 Helix-turn-helix domains; Region: HTH; cl00088 889932008222 Helix-turn-helix domains; Region: HTH; cl00088 889932008223 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 889932008224 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 889932008225 PYR/PP interface [polypeptide binding]; other site 889932008226 dimer interface [polypeptide binding]; other site 889932008227 tetramer interface [polypeptide binding]; other site 889932008228 TPP binding site [chemical binding]; other site 889932008229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 889932008230 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 889932008231 TPP-binding site [chemical binding]; other site 889932008232 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 889932008233 Predicted membrane protein [Function unknown]; Region: COG2364 889932008234 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 889932008235 intersubunit interface [polypeptide binding]; other site 889932008236 active site 889932008237 Zn2+ binding site [ion binding]; other site 889932008238 Domain of unknown function (DUF718); Region: DUF718; cl01281 889932008239 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 889932008240 N- and C-terminal domain interface [polypeptide binding]; other site 889932008241 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 889932008242 active site 889932008243 catalytic site [active] 889932008244 metal binding site [ion binding]; metal-binding site 889932008245 ATP binding site [chemical binding]; other site 889932008246 carbohydrate binding site [chemical binding]; other site 889932008247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 889932008248 putative substrate translocation pore; other site 889932008249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 889932008250 Cupin domain; Region: Cupin_2; cl09118 889932008251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889932008252 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 889932008253 Helix-turn-helix domains; Region: HTH; cl00088 889932008254 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 889932008255 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 889932008256 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932008257 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932008258 Helix-turn-helix domains; Region: HTH; cl00088 889932008259 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932008260 Gram positive anchor; Region: Gram_pos_anchor; cl15427 889932008261 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932008262 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 889932008263 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 889932008264 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932008265 Helix-turn-helix domain; Region: HTH_18; pfam12833 889932008266 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932008267 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932008268 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 889932008269 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 889932008270 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 889932008271 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 889932008272 active site 889932008273 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 889932008274 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 889932008275 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 889932008276 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 889932008277 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932008278 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932008279 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 889932008280 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 889932008281 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 889932008282 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 889932008283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932008284 DNA-binding site [nucleotide binding]; DNA binding site 889932008285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932008286 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889932008287 ligand binding site [chemical binding]; other site 889932008288 dimerization interface [polypeptide binding]; other site 889932008289 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 889932008290 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 889932008291 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 889932008292 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 889932008293 Walker A/P-loop; other site 889932008294 ATP binding site [chemical binding]; other site 889932008295 Q-loop/lid; other site 889932008296 ABC transporter signature motif; other site 889932008297 Walker B; other site 889932008298 D-loop; other site 889932008299 H-loop/switch region; other site 889932008300 TOBE domain; Region: TOBE_2; cl01440 889932008301 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 889932008302 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 889932008303 Response regulator receiver domain; Region: Response_reg; pfam00072 889932008304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932008305 active site 889932008306 phosphorylation site [posttranslational modification] 889932008307 intermolecular recognition site; other site 889932008308 dimerization interface [polypeptide binding]; other site 889932008309 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 889932008310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932008311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 889932008312 Histidine kinase; Region: His_kinase; pfam06580 889932008313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 889932008314 Protein of unknown function, DUF624; Region: DUF624; cl02369 889932008315 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 889932008316 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 889932008317 Ca binding site [ion binding]; other site 889932008318 active site 889932008319 catalytic site [active] 889932008320 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 889932008321 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 889932008322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932008323 dimer interface [polypeptide binding]; other site 889932008324 conserved gate region; other site 889932008325 putative PBP binding loops; other site 889932008326 ABC-ATPase subunit interface; other site 889932008327 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 889932008328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 889932008329 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 889932008330 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 889932008331 putative active site [active] 889932008332 Cupin domain; Region: Cupin_2; cl09118 889932008333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932008334 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 889932008335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 889932008336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932008337 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932008338 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 889932008339 Walker A/P-loop; other site 889932008340 ATP binding site [chemical binding]; other site 889932008341 Q-loop/lid; other site 889932008342 ABC transporter signature motif; other site 889932008343 Walker B; other site 889932008344 D-loop; other site 889932008345 H-loop/switch region; other site 889932008346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 889932008347 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 889932008348 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 889932008349 Walker A/P-loop; other site 889932008350 ATP binding site [chemical binding]; other site 889932008351 Q-loop/lid; other site 889932008352 ABC transporter signature motif; other site 889932008353 Walker B; other site 889932008354 D-loop; other site 889932008355 H-loop/switch region; other site 889932008356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 889932008357 DNA-binding site [nucleotide binding]; DNA binding site 889932008358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932008359 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889932008360 ligand binding site [chemical binding]; other site 889932008361 dimerization interface [polypeptide binding]; other site 889932008362 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 889932008363 Helix-turn-helix domains; Region: HTH; cl00088 889932008364 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 889932008365 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 889932008366 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 889932008367 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 889932008368 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 889932008369 Glucitol operon activator protein (GutM); Region: GutM; cl01890 889932008370 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 889932008371 Helix-turn-helix domains; Region: HTH; cl00088 889932008372 PRD domain; Region: PRD; cl15445 889932008373 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 889932008374 active site 889932008375 phosphorylation site [posttranslational modification] 889932008376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 889932008377 classical (c) SDRs; Region: SDR_c; cd05233 889932008378 NAD(P) binding site [chemical binding]; other site 889932008379 active site 889932008380 Sugar transport protein; Region: Sugar_transport; pfam06800 889932008381 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 889932008382 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 889932008383 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 889932008384 substrate binding site [chemical binding]; other site 889932008385 dimer interface [polypeptide binding]; other site 889932008386 ATP binding site [chemical binding]; other site 889932008387 Transcriptional regulators [Transcription]; Region: PurR; COG1609 889932008388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 889932008389 DNA binding site [nucleotide binding] 889932008390 domain linker motif; other site 889932008391 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 889932008392 dimerization interface [polypeptide binding]; other site 889932008393 ligand binding site [chemical binding]; other site 889932008394 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 889932008395 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 889932008396 putative catalytic cysteine [active] 889932008397 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 889932008398 putative active site [active] 889932008399 metal binding site [ion binding]; metal-binding site 889932008400 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 889932008401 Ligand Binding Site [chemical binding]; other site 889932008402 Helix-turn-helix domains; Region: HTH; cl00088 889932008403 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 889932008404 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 889932008405 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 889932008406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 889932008407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 889932008408 Coenzyme A binding pocket [chemical binding]; other site 889932008409 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 889932008410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 889932008411 non-specific DNA binding site [nucleotide binding]; other site 889932008412 salt bridge; other site 889932008413 sequence-specific DNA binding site [nucleotide binding]; other site 889932008414 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 889932008415 trimer interface [polypeptide binding]; other site 889932008416 active site 889932008417 G bulge; other site 889932008418 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 889932008419 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 889932008420 Catalytic site [active] 889932008421 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 889932008422 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 889932008423 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 889932008424 WxL domain surface cell wall-binding; Region: WxL; pfam13731 889932008425 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 889932008426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 889932008427 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 889932008428 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 889932008429 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 889932008430 trmE is a tRNA modification GTPase; Region: trmE; cd04164 889932008431 G1 box; other site 889932008432 GTP/Mg2+ binding site [chemical binding]; other site 889932008433 Switch I region; other site 889932008434 G2 box; other site 889932008435 Switch II region; other site 889932008436 G3 box; other site 889932008437 G4 box; other site 889932008438 G5 box; other site 889932008439 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 889932008440 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 889932008441 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 889932008442 G-X-X-G motif; other site 889932008443 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 889932008444 RxxxH motif; other site 889932008445 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 889932008446 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 889932008447 active site 889932008448 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 889932008449 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 889932008450 peptide binding site [polypeptide binding]; other site 889932008451 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 889932008452 Ribonuclease P; Region: Ribonuclease_P; cl00457 889932008453 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 889932008454 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 889932008455 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889932008456 P-loop; other site 889932008457 Magnesium ion binding site [ion binding]; other site 889932008458 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 889932008459 Magnesium ion binding site [ion binding]; other site 889932008460 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932008461 Helix-turn-helix domains; Region: HTH; cl00088 889932008462 Integrase core domain; Region: rve; cl01316 889932008463 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932008464 Integrase core domain; Region: rve; cl01316 889932008465 Transposase; Region: DDE_Tnp_ISL3; pfam01610 889932008466 NMT1-like family; Region: NMT1_2; cl15260 889932008467 NMT1-like family; Region: NMT1_2; cl15260 889932008468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 889932008469 dimer interface [polypeptide binding]; other site 889932008470 conserved gate region; other site 889932008471 putative PBP binding loops; other site 889932008472 ABC-ATPase subunit interface; other site 889932008473 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 889932008474 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 889932008475 Walker A/P-loop; other site 889932008476 ATP binding site [chemical binding]; other site 889932008477 Q-loop/lid; other site 889932008478 ABC transporter signature motif; other site 889932008479 Walker B; other site 889932008480 D-loop; other site 889932008481 H-loop/switch region; other site 889932008482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 889932008483 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932008484 Helix-turn-helix domains; Region: HTH; cl00088 889932008485 Helix-turn-helix domains; Region: HTH; cl00088 889932008486 Integrase core domain; Region: rve; cl01316 889932008487 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 889932008488 putative peptidoglycan binding site; other site 889932008489 Transposase; Region: DEDD_Tnp_IS110; pfam01548 889932008490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 889932008491 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 889932008492 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 889932008493 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 889932008494 Cl- selectivity filter; other site 889932008495 Cl- binding residues [ion binding]; other site 889932008496 pore gating glutamate residue; other site 889932008497 dimer interface [polypeptide binding]; other site 889932008498 H+/Cl- coupling transport residue; other site 889932008499 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 889932008500 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 889932008501 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 889932008502 Uncharacterized conserved protein [Function unknown]; Region: COG1284 889932008503 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 889932008504 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 889932008505 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 889932008506 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 889932008507 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 889932008508 catalytic residues [active] 889932008509 catalytic nucleophile [active] 889932008510 Presynaptic Site I dimer interface [polypeptide binding]; other site 889932008511 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 889932008512 Synaptic Flat tetramer interface [polypeptide binding]; other site 889932008513 Synaptic Site I dimer interface [polypeptide binding]; other site 889932008514 DNA binding site [nucleotide binding] 889932008515 Helix-turn-helix domains; Region: HTH; cl00088 889932008516 Integrase core domain; Region: rve; cl01316 889932008517 Integrase core domain; Region: rve_3; cl15866 889932008518 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 889932008519 dimer interface [polypeptide binding]; other site 889932008520 diiron center [ion binding]; other site 889932008521 putative radical transfer pathway; other site 889932008522 tyrosyl radical; other site 889932008523 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 889932008524 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 889932008525 dinuclear metal binding motif [ion binding]; other site 889932008526 Class I ribonucleotide reductase; Region: RNR_I; cd01679 889932008527 active site 889932008528 dimer interface [polypeptide binding]; other site 889932008529 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 889932008530 catalytic residues [active] 889932008531 effector binding site; other site 889932008532 R2 peptide binding site; other site 889932008533 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 889932008534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 889932008535 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 889932008536 Helix-turn-helix domains; Region: HTH; cl00088 889932008537 Integrase core domain; Region: rve; cl01316 889932008538 multiple promoter invertase; Provisional; Region: mpi; PRK13413 889932008539 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 889932008540 catalytic residues [active] 889932008541 catalytic nucleophile [active] 889932008542 Presynaptic Site I dimer interface [polypeptide binding]; other site 889932008543 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 889932008544 Synaptic Flat tetramer interface [polypeptide binding]; other site 889932008545 Synaptic Site I dimer interface [polypeptide binding]; other site 889932008546 DNA binding site [nucleotide binding] 889932008547 Transcriptional regulators [Transcription]; Region: MarR; COG1846 889932008548 Helix-turn-helix domains; Region: HTH; cl00088 889932008549 K+ potassium transporter; Region: K_trans; cl15781 889932008550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 889932008551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 889932008552 active site 889932008553 phosphorylation site [posttranslational modification] 889932008554 intermolecular recognition site; other site 889932008555 dimerization interface [polypeptide binding]; other site 889932008556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 889932008557 DNA binding site [nucleotide binding] 889932008558 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 889932008559 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 889932008560 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 889932008561 Ligand Binding Site [chemical binding]; other site 889932008562 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 889932008563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 889932008564 dimer interface [polypeptide binding]; other site 889932008565 phosphorylation site [posttranslational modification] 889932008566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 889932008567 ATP binding site [chemical binding]; other site 889932008568 G-X-G motif; other site 889932008569 K+-transporting ATPase, c chain; Region: KdpC; cl00944 889932008570 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 889932008571 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 889932008572 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 889932008573 cyclase homology domain; Region: CHD; cd07302 889932008574 nucleotidyl binding site; other site 889932008575 metal binding site [ion binding]; metal-binding site 889932008576 dimer interface [polypeptide binding]; other site 889932008577 DNA polymerase IV; Reviewed; Region: PRK03103 889932008578 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 889932008579 active site 889932008580 DNA binding site [nucleotide binding] 889932008581 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 889932008582 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 889932008583 Domain of unknown function (DUF955); Region: DUF955; cl01076 889932008584 MobA/MobL family; Region: MobA_MobL; pfam03389 889932008585 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 889932008586 RelB antitoxin; Region: RelB; cl01171