-- dump date 20111121_012826 -- class Genbank::misc_feature -- table misc_feature_note -- id note 568703000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 568703000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703000003 Walker A motif; other site 568703000004 ATP binding site [chemical binding]; other site 568703000005 Walker B motif; other site 568703000006 arginine finger; other site 568703000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 568703000008 DnaA box-binding interface [nucleotide binding]; other site 568703000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 568703000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 568703000011 putative DNA binding surface [nucleotide binding]; other site 568703000012 dimer interface [polypeptide binding]; other site 568703000013 beta-clamp/clamp loader binding surface; other site 568703000014 beta-clamp/translesion DNA polymerase binding surface; other site 568703000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 568703000016 recombination protein F; Reviewed; Region: recF; PRK00064 568703000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 568703000018 Walker A/P-loop; other site 568703000019 ATP binding site [chemical binding]; other site 568703000020 Q-loop/lid; other site 568703000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000022 ABC transporter signature motif; other site 568703000023 Walker B; other site 568703000024 D-loop; other site 568703000025 H-loop/switch region; other site 568703000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 568703000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568703000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 568703000029 anchoring element; other site 568703000030 dimer interface [polypeptide binding]; other site 568703000031 ATP binding site [chemical binding]; other site 568703000032 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568703000033 active site 568703000034 metal binding site [ion binding]; metal-binding site 568703000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703000036 DNA gyrase subunit A; Validated; Region: PRK05560 568703000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 568703000038 CAP-like domain; other site 568703000039 Active site [active] 568703000040 primary dimer interface [polypeptide binding]; other site 568703000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703000047 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 568703000048 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000049 dimer interface [polypeptide binding]; other site 568703000050 ssDNA binding site [nucleotide binding]; other site 568703000051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000052 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 568703000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703000054 dimer interface [polypeptide binding]; other site 568703000055 ssDNA binding site [nucleotide binding]; other site 568703000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703000057 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 568703000058 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 568703000059 proposed catalytic triad [active] 568703000060 conserved cys residue [active] 568703000061 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703000062 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 568703000063 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703000064 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703000065 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703000066 Integrase core domain; Region: rve; cl01316 568703000067 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703000068 Transposase domain (DUF772); Region: DUF772; cl12084 568703000069 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703000070 ABC-2 type transporter; Region: ABC2_membrane; cl11417 568703000071 Transposase domain (DUF772); Region: DUF772; cl12084 568703000072 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703000073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000074 Walker A/P-loop; other site 568703000075 ATP binding site [chemical binding]; other site 568703000076 Q-loop/lid; other site 568703000077 ABC transporter signature motif; other site 568703000078 Walker B; other site 568703000079 D-loop; other site 568703000080 H-loop/switch region; other site 568703000081 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 568703000082 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 568703000083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703000085 NlpC/P60 family; Region: NLPC_P60; cl11438 568703000086 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 568703000087 FtsX-like permease family; Region: FtsX; pfam02687 568703000088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000089 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703000090 Walker A/P-loop; other site 568703000091 ATP binding site [chemical binding]; other site 568703000092 Q-loop/lid; other site 568703000093 ABC transporter signature motif; other site 568703000094 Walker B; other site 568703000095 D-loop; other site 568703000096 H-loop/switch region; other site 568703000097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703000100 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703000101 active site 568703000102 motif I; other site 568703000103 motif II; other site 568703000104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703000105 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000106 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703000107 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 568703000108 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 568703000109 active site 568703000110 substrate binding site [chemical binding]; other site 568703000111 trimer interface [polypeptide binding]; other site 568703000112 CoA binding site [chemical binding]; other site 568703000113 Peptidase family C69; Region: Peptidase_C69; cl01920 568703000114 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 568703000115 active site 568703000116 AzlC protein; Region: AzlC; cl00570 568703000117 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 568703000118 beta-D-glucuronidase; Provisional; Region: PRK10150 568703000119 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703000120 domain; Region: Glyco_hydro_2; pfam00703 568703000121 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000122 hypothetical protein; Provisional; Region: PRK11281 568703000123 Entner-Doudoroff aldolase; Region: eda; TIGR01182 568703000124 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703000125 active site 568703000126 intersubunit interface [polypeptide binding]; other site 568703000127 catalytic residue [active] 568703000128 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 568703000129 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000130 substrate binding site [chemical binding]; other site 568703000131 ATP binding site [chemical binding]; other site 568703000132 Glucuronate isomerase; Region: UxaC; cl00829 568703000133 Glucuronate isomerase; Region: UxaC; cl00829 568703000134 mannonate dehydratase; Region: uxuA; TIGR00695 568703000135 mannonate dehydratase; Provisional; Region: PRK03906 568703000136 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 568703000137 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703000138 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703000139 melibiose:sodium symporter; Provisional; Region: PRK10429 568703000140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000141 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703000142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000143 DNA-binding site [nucleotide binding]; DNA binding site 568703000144 FCD domain; Region: FCD; cl11656 568703000145 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000146 substrate binding site [chemical binding]; other site 568703000147 ATP binding site [chemical binding]; other site 568703000148 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 568703000149 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568703000150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000152 putative substrate translocation pore; other site 568703000153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000154 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703000155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000157 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 568703000158 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 568703000159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000161 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703000162 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 568703000163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703000164 active site 568703000165 putative diguanylate cyclase; Provisional; Region: PRK09776 568703000166 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 568703000167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703000168 dimer interface [polypeptide binding]; other site 568703000169 conserved gate region; other site 568703000170 putative PBP binding loops; other site 568703000171 ABC-ATPase subunit interface; other site 568703000172 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703000173 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703000174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703000175 dimer interface [polypeptide binding]; other site 568703000176 conserved gate region; other site 568703000177 putative PBP binding loops; other site 568703000178 ABC-ATPase subunit interface; other site 568703000179 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 568703000180 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 568703000181 Walker A/P-loop; other site 568703000182 ATP binding site [chemical binding]; other site 568703000183 Q-loop/lid; other site 568703000184 ABC transporter signature motif; other site 568703000185 Walker B; other site 568703000186 D-loop; other site 568703000187 H-loop/switch region; other site 568703000188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 568703000189 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 568703000190 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 568703000191 DNA binding residues [nucleotide binding] 568703000192 dimer interface [polypeptide binding]; other site 568703000193 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000194 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703000196 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 568703000197 metal-binding site [ion binding] 568703000198 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 568703000199 dinuclear metal binding motif [ion binding]; other site 568703000200 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 568703000201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 568703000202 ligand binding site [chemical binding]; other site 568703000203 flexible hinge region; other site 568703000204 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 568703000205 putative switch regulator; other site 568703000206 non-specific DNA interactions [nucleotide binding]; other site 568703000207 DNA binding site [nucleotide binding] 568703000208 sequence specific DNA binding site [nucleotide binding]; other site 568703000209 putative cAMP binding site [chemical binding]; other site 568703000210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000212 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703000213 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 568703000214 P-loop; other site 568703000215 active site 568703000216 phosphorylation site [posttranslational modification] 568703000217 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000218 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000219 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000220 active site 568703000221 phosphorylation site [posttranslational modification] 568703000222 alpha-mannosidase; Provisional; Region: PRK09819 568703000223 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 568703000224 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 568703000225 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000226 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703000227 putative active site [active] 568703000228 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703000229 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 568703000230 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703000231 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 568703000232 tryptophan synthase; Region: PLN02591 568703000233 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 568703000234 substrate binding site [chemical binding]; other site 568703000235 active site 568703000236 catalytic residues [active] 568703000237 heterodimer interface [polypeptide binding]; other site 568703000238 tryptophan synthase, beta chain; Region: PLN02618 568703000239 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 568703000240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000241 catalytic residue [active] 568703000242 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 568703000243 active site 568703000244 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 568703000245 active site 568703000246 ribulose/triose binding site [chemical binding]; other site 568703000247 phosphate binding site [ion binding]; other site 568703000248 substrate (anthranilate) binding pocket [chemical binding]; other site 568703000249 product (indole) binding pocket [chemical binding]; other site 568703000250 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 568703000251 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703000252 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703000253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000255 putative substrate translocation pore; other site 568703000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000259 Cupin domain; Region: Cupin_2; cl09118 568703000260 dihydrodipicolinate reductase; Provisional; Region: PRK00048 568703000261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000262 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 568703000263 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 568703000264 dihydrodipicolinate synthase; Region: dapA; TIGR00674 568703000265 dimer interface [polypeptide binding]; other site 568703000266 active site 568703000267 catalytic residue [active] 568703000268 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703000269 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 568703000270 metal binding site [ion binding]; metal-binding site 568703000271 putative dimer interface [polypeptide binding]; other site 568703000272 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 568703000273 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 568703000274 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000275 putative trimer interface [polypeptide binding]; other site 568703000276 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 568703000277 putative CoA binding site [chemical binding]; other site 568703000278 putative trimer interface [polypeptide binding]; other site 568703000279 putative CoA binding site [chemical binding]; other site 568703000280 diaminopimelate decarboxylase; Region: lysA; TIGR01048 568703000281 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 568703000282 active site 568703000283 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703000284 substrate binding site [chemical binding]; other site 568703000285 catalytic residues [active] 568703000286 dimer interface [polypeptide binding]; other site 568703000287 aspartate kinase; Reviewed; Region: PRK09034 568703000288 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 568703000289 putative catalytic residues [active] 568703000290 putative nucleotide binding site [chemical binding]; other site 568703000291 putative aspartate binding site [chemical binding]; other site 568703000292 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 568703000293 allosteric regulatory residue; other site 568703000294 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703000295 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 568703000296 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 568703000297 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 568703000298 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 568703000299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000300 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 568703000301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000302 non-specific DNA binding site [nucleotide binding]; other site 568703000303 salt bridge; other site 568703000304 sequence-specific DNA binding site [nucleotide binding]; other site 568703000305 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 568703000306 nudix motif; other site 568703000307 EamA-like transporter family; Region: EamA; cl01037 568703000308 xanthine dehydrogenase; Region: PLN02906 568703000309 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 568703000310 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 568703000311 DHH family; Region: DHH; pfam01368 568703000312 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 568703000313 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 568703000314 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 568703000315 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 568703000316 replicative DNA helicase; Provisional; Region: PRK05748 568703000317 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 568703000318 Walker A motif; other site 568703000319 ATP binding site [chemical binding]; other site 568703000320 Walker B motif; other site 568703000321 DNA binding loops [nucleotide binding] 568703000322 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703000323 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703000324 active site turn [active] 568703000325 phosphorylation site [posttranslational modification] 568703000326 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000327 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 568703000328 HPr interaction site; other site 568703000329 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703000330 active site 568703000331 phosphorylation site [posttranslational modification] 568703000332 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703000333 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703000334 putative active site [active] 568703000335 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703000336 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703000337 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000338 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703000339 putative active site [active] 568703000340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703000341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703000342 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000343 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703000344 Walker A/P-loop; other site 568703000345 ATP binding site [chemical binding]; other site 568703000346 Q-loop/lid; other site 568703000347 ABC transporter signature motif; other site 568703000348 Walker B; other site 568703000349 D-loop; other site 568703000350 H-loop/switch region; other site 568703000351 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703000352 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 568703000353 FtsX-like permease family; Region: FtsX; pfam02687 568703000354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703000355 adenylosuccinate synthetase; Provisional; Region: PRK01117 568703000356 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 568703000357 GDP-binding site [chemical binding]; other site 568703000358 ACT binding site; other site 568703000359 IMP binding site; other site 568703000360 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 568703000361 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703000362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703000363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703000364 dimerization interface [polypeptide binding]; other site 568703000365 putative DNA binding site [nucleotide binding]; other site 568703000366 putative Zn2+ binding site [ion binding]; other site 568703000367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000368 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 568703000369 ATP cone domain; Region: ATP-cone; pfam03477 568703000370 Class III ribonucleotide reductase; Region: RNR_III; cd01675 568703000371 effector binding site; other site 568703000372 active site 568703000373 Zn binding site [ion binding]; other site 568703000374 glycine loop; other site 568703000375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000376 non-specific DNA binding site [nucleotide binding]; other site 568703000377 salt bridge; other site 568703000378 sequence-specific DNA binding site [nucleotide binding]; other site 568703000379 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703000380 Transposase; Region: DEDD_Tnp_IS110; pfam01548 568703000381 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 568703000382 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 568703000383 active site 568703000384 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 568703000385 putative dimer interface [polypeptide binding]; other site 568703000386 catalytic triad [active] 568703000387 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 568703000388 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 568703000389 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703000390 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703000391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703000393 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703000394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703000395 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 568703000396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703000397 dimer interface [polypeptide binding]; other site 568703000398 phosphorylation site [posttranslational modification] 568703000399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000400 ATP binding site [chemical binding]; other site 568703000401 Mg2+ binding site [ion binding]; other site 568703000402 G-X-G motif; other site 568703000403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703000405 active site 568703000406 phosphorylation site [posttranslational modification] 568703000407 intermolecular recognition site; other site 568703000408 dimerization interface [polypeptide binding]; other site 568703000409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703000410 DNA binding site [nucleotide binding] 568703000411 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 568703000412 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 568703000413 DNA binding site [nucleotide binding] 568703000414 active site 568703000415 D-lactate dehydrogenase; Validated; Region: PRK08605 568703000416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000417 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000418 active site 568703000419 P-loop; other site 568703000420 phosphorylation site [posttranslational modification] 568703000421 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000422 active site 568703000423 methionine cluster; other site 568703000424 phosphorylation site [posttranslational modification] 568703000425 metal binding site [ion binding]; metal-binding site 568703000426 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000427 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703000428 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 568703000429 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000431 DNA-binding site [nucleotide binding]; DNA binding site 568703000432 UTRA domain; Region: UTRA; cl01230 568703000433 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 568703000434 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 568703000435 Sulfate transporter family; Region: Sulfate_transp; cl00967 568703000436 DsrE/DsrF-like family; Region: DrsE; cl00672 568703000437 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000438 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 568703000439 Walker A/P-loop; other site 568703000440 ATP binding site [chemical binding]; other site 568703000441 Q-loop/lid; other site 568703000442 ABC transporter signature motif; other site 568703000443 Walker B; other site 568703000444 D-loop; other site 568703000445 H-loop/switch region; other site 568703000446 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703000447 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703000448 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 568703000450 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 568703000451 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 568703000452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000453 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703000455 active site residue [active] 568703000456 putative inner membrane protein; Provisional; Region: PRK11099 568703000457 putative inner membrane protein; Provisional; Region: PRK11099 568703000458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703000460 dimerization interface [polypeptide binding]; other site 568703000461 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703000462 Zn binding site [ion binding]; other site 568703000463 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703000464 Zn binding site [ion binding]; other site 568703000465 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703000466 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703000467 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703000468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000469 Protein of unknown function (DUF805); Region: DUF805; cl01224 568703000470 Protein of unknown function (DUF805); Region: DUF805; cl01224 568703000471 recombination factor protein RarA; Reviewed; Region: PRK13342 568703000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703000473 Walker A motif; other site 568703000474 ATP binding site [chemical binding]; other site 568703000475 Walker B motif; other site 568703000476 arginine finger; other site 568703000477 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703000478 Acetokinase family; Region: Acetate_kinase; cl01029 568703000479 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000481 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703000482 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703000483 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 568703000484 N- and C-terminal domain interface [polypeptide binding]; other site 568703000485 active site 568703000486 MgATP binding site [chemical binding]; other site 568703000487 catalytic site [active] 568703000488 metal binding site [ion binding]; metal-binding site 568703000489 carbohydrate binding site [chemical binding]; other site 568703000490 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703000491 hypothetical protein; Provisional; Region: PRK08185 568703000492 intersubunit interface [polypeptide binding]; other site 568703000493 active site 568703000494 zinc binding site [ion binding]; other site 568703000495 Na+ binding site [ion binding]; other site 568703000496 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000497 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 568703000498 active site 568703000499 metal binding site [ion binding]; metal-binding site 568703000500 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703000501 endonuclease III; Region: ENDO3c; smart00478 568703000502 minor groove reading motif; other site 568703000503 helix-hairpin-helix signature motif; other site 568703000504 substrate binding pocket [chemical binding]; other site 568703000505 active site 568703000506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703000508 putative substrate translocation pore; other site 568703000509 putative phosphoketolase; Provisional; Region: PRK05261 568703000510 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 568703000511 TPP-binding site; other site 568703000512 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 568703000513 XFP C-terminal domain; Region: XFP_C; pfam09363 568703000514 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000515 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000516 peptide binding site [polypeptide binding]; other site 568703000517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000518 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703000519 Walker A/P-loop; other site 568703000520 ATP binding site [chemical binding]; other site 568703000521 Q-loop/lid; other site 568703000522 ABC transporter signature motif; other site 568703000523 Walker B; other site 568703000524 D-loop; other site 568703000525 H-loop/switch region; other site 568703000526 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 568703000527 nudix motif; other site 568703000528 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703000529 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 568703000530 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 568703000531 Walker A/P-loop; other site 568703000532 ATP binding site [chemical binding]; other site 568703000533 Q-loop/lid; other site 568703000534 ABC transporter signature motif; other site 568703000535 Walker B; other site 568703000536 D-loop; other site 568703000537 H-loop/switch region; other site 568703000538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000539 non-specific DNA binding site [nucleotide binding]; other site 568703000540 salt bridge; other site 568703000541 sequence-specific DNA binding site [nucleotide binding]; other site 568703000542 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703000543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 568703000544 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000546 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703000547 Domain of unknown function (DUF477); Region: DUF477; cl01535 568703000548 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 568703000549 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 568703000550 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703000551 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 568703000552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000553 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568703000554 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 568703000555 Protein of unknown function (DUF322); Region: DUF322; cl00574 568703000556 Protein of unknown function (DUF322); Region: DUF322; cl00574 568703000557 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 568703000558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703000559 motif II; other site 568703000560 Protein of unknown function (DUF969); Region: DUF969; cl01573 568703000561 Protein of unknown function (DUF979); Region: DUF979; cl01572 568703000562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703000563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703000564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703000565 Protein of unknown function (DUF979); Region: DUF979; cl01572 568703000566 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 568703000567 putative substrate binding pocket [chemical binding]; other site 568703000568 AC domain interface; other site 568703000569 catalytic triad [active] 568703000570 AB domain interface; other site 568703000571 interchain disulfide; other site 568703000572 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703000573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000574 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 568703000575 catalytic triad [active] 568703000576 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 568703000577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703000578 ParB-like partition proteins; Region: parB_part; TIGR00180 568703000579 ParB-like nuclease domain; Region: ParBc; cl02129 568703000580 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 568703000581 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 568703000582 ParB-like partition proteins; Region: parB_part; TIGR00180 568703000583 ParB-like nuclease domain; Region: ParBc; cl02129 568703000584 KorB domain; Region: KorB; pfam08535 568703000585 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 568703000586 GTP-binding protein YchF; Reviewed; Region: PRK09601 568703000587 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 568703000588 G1 box; other site 568703000589 GTP/Mg2+ binding site [chemical binding]; other site 568703000590 Switch I region; other site 568703000591 G2 box; other site 568703000592 Switch II region; other site 568703000593 G3 box; other site 568703000594 G4 box; other site 568703000595 G5 box; other site 568703000596 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 568703000597 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 568703000598 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 568703000599 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703000600 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703000601 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 568703000602 active site 568703000603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703000604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703000605 active site 568703000606 phosphorylation site [posttranslational modification] 568703000607 intermolecular recognition site; other site 568703000608 dimerization interface [polypeptide binding]; other site 568703000609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703000610 DNA binding site [nucleotide binding] 568703000611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703000612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703000613 dimer interface [polypeptide binding]; other site 568703000614 phosphorylation site [posttranslational modification] 568703000615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703000616 ATP binding site [chemical binding]; other site 568703000617 Mg2+ binding site [ion binding]; other site 568703000618 G-X-G motif; other site 568703000619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 568703000620 Beta-lactamase; Region: Beta-lactamase; cl01009 568703000621 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 568703000622 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703000623 domain; Region: GreA_GreB_N; pfam03449 568703000624 C-term; Region: GreA_GreB; pfam01272 568703000625 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 568703000626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703000627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703000628 aspartate racemase; Region: asp_race; TIGR00035 568703000629 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568703000630 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703000631 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703000632 active site 568703000633 catalytic tetrad [active] 568703000634 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000636 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703000637 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703000638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000639 putative substrate translocation pore; other site 568703000640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000641 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 568703000642 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568703000643 tetrameric interface [polypeptide binding]; other site 568703000644 NAD binding site [chemical binding]; other site 568703000645 catalytic residues [active] 568703000646 KduI/IolB family; Region: KduI; cl01508 568703000647 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 568703000648 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 568703000649 substrate binding site [chemical binding]; other site 568703000650 ATP binding site [chemical binding]; other site 568703000651 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 568703000652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703000653 PYR/PP interface [polypeptide binding]; other site 568703000654 dimer interface [polypeptide binding]; other site 568703000655 TPP binding site [chemical binding]; other site 568703000656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703000657 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 568703000658 TPP-binding site; other site 568703000659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703000662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000663 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 568703000664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000665 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703000666 hypothetical protein; Provisional; Region: PRK08185 568703000667 intersubunit interface [polypeptide binding]; other site 568703000668 active site 568703000669 zinc binding site [ion binding]; other site 568703000670 Na+ binding site [ion binding]; other site 568703000671 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568703000672 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 568703000673 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703000674 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703000675 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703000676 putative active site [active] 568703000677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000678 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 568703000679 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 568703000680 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 568703000681 N- and C-terminal domain interface [polypeptide binding]; other site 568703000682 putative active site [active] 568703000683 catalytic site [active] 568703000684 metal binding site [ion binding]; metal-binding site 568703000685 carbohydrate binding site [chemical binding]; other site 568703000686 ATP binding site [chemical binding]; other site 568703000687 GntP family permease; Region: GntP_permease; cl15264 568703000688 Citrate transporter; Region: CitMHS; pfam03600 568703000689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703000690 active site 568703000691 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000692 Probable Catalytic site [active] 568703000693 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703000694 Probable Catalytic site [active] 568703000695 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703000696 MatE; Region: MatE; cl10513 568703000697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703000698 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 568703000699 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 568703000700 putative PBP binding regions; other site 568703000701 ABC-ATPase subunit interface; other site 568703000702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703000703 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703000704 active site 568703000705 metal binding site [ion binding]; metal-binding site 568703000706 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568703000707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000708 oligoendopeptidase F; Region: pepF; TIGR00181 568703000709 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 568703000710 active site 568703000711 Zn binding site [ion binding]; other site 568703000712 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703000713 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703000714 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703000715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000716 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703000717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703000718 active site 568703000719 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703000720 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 568703000721 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000722 Catalytic site [active] 568703000723 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 568703000724 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 568703000725 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703000726 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703000727 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000728 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703000729 ABC transporter; Region: ABC_tran_2; pfam12848 568703000730 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703000731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703000732 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703000733 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703000734 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703000735 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703000736 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 568703000737 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 568703000738 putative ligand binding site [chemical binding]; other site 568703000739 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 568703000740 TM-ABC transporter signature motif; other site 568703000741 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 568703000742 TM-ABC transporter signature motif; other site 568703000743 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 568703000744 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 568703000745 Walker A/P-loop; other site 568703000746 ATP binding site [chemical binding]; other site 568703000747 Q-loop/lid; other site 568703000748 ABC transporter signature motif; other site 568703000749 Walker B; other site 568703000750 D-loop; other site 568703000751 H-loop/switch region; other site 568703000752 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703000753 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 568703000754 Walker A/P-loop; other site 568703000755 ATP binding site [chemical binding]; other site 568703000756 Q-loop/lid; other site 568703000757 ABC transporter signature motif; other site 568703000758 Walker B; other site 568703000759 D-loop; other site 568703000760 H-loop/switch region; other site 568703000761 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 568703000762 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703000763 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000764 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 568703000765 intersubunit interface [polypeptide binding]; other site 568703000766 active site 568703000767 catalytic residue [active] 568703000768 Sulfatase; Region: Sulfatase; cl10460 568703000769 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 568703000770 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 568703000771 NlpC/P60 family; Region: NLPC_P60; cl11438 568703000772 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703000773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703000774 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 568703000775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000776 DEAD_2; Region: DEAD_2; cl14887 568703000777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000778 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703000779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703000780 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 568703000781 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 568703000782 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703000783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703000784 DNA-binding site [nucleotide binding]; DNA binding site 568703000785 UTRA domain; Region: UTRA; cl01230 568703000786 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 568703000787 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703000788 dimer interface [polypeptide binding]; other site 568703000789 active site 568703000790 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases (...; Region: SIS_AgaS_like; cd05010 568703000791 putative active site [active] 568703000792 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703000793 active site 568703000794 dimer interface [polypeptide binding]; other site 568703000795 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 568703000796 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 568703000797 active site 568703000798 phosphorylation site [posttranslational modification] 568703000799 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703000800 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703000801 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 568703000802 active pocket/dimerization site; other site 568703000803 active site 568703000804 phosphorylation site [posttranslational modification] 568703000805 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703000806 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703000807 putative substrate binding site [chemical binding]; other site 568703000808 putative ATP binding site [chemical binding]; other site 568703000809 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568703000810 classical (c) SDRs; Region: SDR_c; cd05233 568703000811 NAD(P) binding site [chemical binding]; other site 568703000812 active site 568703000813 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000814 Transposase domain (DUF772); Region: DUF772; cl12084 568703000815 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000816 active site 568703000817 phosphorylation site [posttranslational modification] 568703000818 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703000819 P-loop; other site 568703000820 active site 568703000821 phosphorylation site [posttranslational modification] 568703000822 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000823 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703000824 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000825 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703000826 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703000827 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703000828 Rap/ran-GAP; Region: Rap_GAP; pfam02145 568703000829 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 568703000830 aspartate aminotransferase; Provisional; Region: PRK08361 568703000831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703000832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703000833 homodimer interface [polypeptide binding]; other site 568703000834 catalytic residue [active] 568703000835 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703000836 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703000837 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703000838 active site 568703000839 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000840 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703000841 active site 568703000842 P-loop; other site 568703000843 phosphorylation site [posttranslational modification] 568703000844 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703000845 active site 568703000846 methionine cluster; other site 568703000847 phosphorylation site [posttranslational modification] 568703000848 metal binding site [ion binding]; metal-binding site 568703000849 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 568703000850 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 568703000851 oligomer interface [polypeptide binding]; other site 568703000852 active site 568703000853 metal binding site [ion binding]; metal-binding site 568703000854 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703000855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000856 PRD domain; Region: PRD; pfam00874 568703000857 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703000858 P-loop; other site 568703000859 active site 568703000860 phosphorylation site [posttranslational modification] 568703000861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000862 active site 568703000863 phosphorylation site [posttranslational modification] 568703000864 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 568703000865 peptidase T; Region: peptidase-T; TIGR01882 568703000866 metal binding site [ion binding]; metal-binding site 568703000867 dimer interface [polypeptide binding]; other site 568703000868 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703000869 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703000870 peptide binding site [polypeptide binding]; other site 568703000871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703000872 Coenzyme A binding pocket [chemical binding]; other site 568703000873 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703000874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703000875 Walker A/P-loop; other site 568703000876 ATP binding site [chemical binding]; other site 568703000877 Q-loop/lid; other site 568703000878 ABC transporter signature motif; other site 568703000879 Walker B; other site 568703000880 D-loop; other site 568703000881 H-loop/switch region; other site 568703000882 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 568703000883 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703000884 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000885 Walker A/P-loop; other site 568703000886 ATP binding site [chemical binding]; other site 568703000887 Q-loop/lid; other site 568703000888 ABC transporter signature motif; other site 568703000889 Walker B; other site 568703000890 D-loop; other site 568703000891 H-loop/switch region; other site 568703000892 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703000893 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703000894 Walker A/P-loop; other site 568703000895 ATP binding site [chemical binding]; other site 568703000896 Q-loop/lid; other site 568703000897 ABC transporter signature motif; other site 568703000898 Walker B; other site 568703000899 D-loop; other site 568703000900 H-loop/switch region; other site 568703000901 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 568703000902 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 568703000903 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 568703000904 substrate binding site [chemical binding]; other site 568703000905 multimerization interface [polypeptide binding]; other site 568703000906 ATP binding site [chemical binding]; other site 568703000907 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 568703000908 thiamine phosphate binding site [chemical binding]; other site 568703000909 active site 568703000910 pyrophosphate binding site [ion binding]; other site 568703000911 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 568703000912 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703000913 dimer interface [polypeptide binding]; other site 568703000914 substrate binding site [chemical binding]; other site 568703000915 ATP binding site [chemical binding]; other site 568703000916 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703000917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703000918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703000919 DNA binding site [nucleotide binding] 568703000920 domain linker motif; other site 568703000921 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703000922 ligand binding site [chemical binding]; other site 568703000923 dimerization interface [polypeptide binding]; other site 568703000924 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 568703000925 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 568703000926 substrate binding site [chemical binding]; other site 568703000927 dimer interface [polypeptide binding]; other site 568703000928 ATP binding site [chemical binding]; other site 568703000929 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 568703000930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000931 salt bridge; other site 568703000932 non-specific DNA binding site [nucleotide binding]; other site 568703000933 sequence-specific DNA binding site [nucleotide binding]; other site 568703000934 Transposase domain (DUF772); Region: DUF772; cl12084 568703000935 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703000936 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 568703000937 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703000938 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703000939 Transposase domain (DUF772); Region: DUF772; cl12084 568703000940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703000941 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703000942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703000943 putative substrate translocation pore; other site 568703000944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000945 Soybean trypsin inhibitor (Kunitz) family of protease inhibitors. Inhibit proteases by binding with high affinity to their active sites. Trefoil fold, common to interleukins and fibroblast growth factors; Region: STI; cl11466 568703000946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703000947 non-specific DNA binding site [nucleotide binding]; other site 568703000948 salt bridge; other site 568703000949 sequence-specific DNA binding site [nucleotide binding]; other site 568703000950 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703000951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703000952 PRD domain; Region: PRD; pfam00874 568703000953 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703000954 P-loop; other site 568703000955 active site 568703000956 phosphorylation site [posttranslational modification] 568703000957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703000958 active site 568703000959 phosphorylation site [posttranslational modification] 568703000960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000961 active site 568703000962 phosphorylation site [posttranslational modification] 568703000963 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 568703000964 P-loop; other site 568703000965 active site 568703000966 phosphorylation site [posttranslational modification] 568703000967 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703000968 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 568703000969 active site 568703000970 intersubunit interactions; other site 568703000971 catalytic residue [active] 568703000972 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 568703000973 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 568703000974 substrate binding site [chemical binding]; other site 568703000975 hexamer interface [polypeptide binding]; other site 568703000976 metal binding site [ion binding]; metal-binding site 568703000977 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703000978 active site 568703000979 phosphorylation site [posttranslational modification] 568703000980 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703000981 P-loop; other site 568703000982 active site 568703000983 phosphorylation site [posttranslational modification] 568703000984 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000985 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703000986 Integrase core domain; Region: rve; cl01316 568703000987 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703000988 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 568703000989 TPP-binding site [chemical binding]; other site 568703000990 dimer interface [polypeptide binding]; other site 568703000991 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 568703000992 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 568703000993 PYR/PP interface [polypeptide binding]; other site 568703000994 dimer interface [polypeptide binding]; other site 568703000995 TPP binding site [chemical binding]; other site 568703000996 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703000997 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703000998 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 568703000999 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001001 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703001002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703001003 active site 568703001004 phosphorylation site [posttranslational modification] 568703001005 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 568703001006 P-loop; other site 568703001007 active site 568703001008 phosphorylation site [posttranslational modification] 568703001009 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703001010 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001011 Integrase core domain; Region: rve; cl01316 568703001012 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703001013 hypothetical protein; Provisional; Region: PRK08185 568703001014 intersubunit interface [polypeptide binding]; other site 568703001015 active site 568703001016 zinc binding site [ion binding]; other site 568703001017 Na+ binding site [ion binding]; other site 568703001018 hypothetical protein; Provisional; Region: PRK08185 568703001019 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703001020 intersubunit interface [polypeptide binding]; other site 568703001021 active site 568703001022 zinc binding site [ion binding]; other site 568703001023 Na+ binding site [ion binding]; other site 568703001024 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 568703001025 active site 568703001026 phosphorylation site [posttranslational modification] 568703001027 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 568703001028 active pocket/dimerization site; other site 568703001029 active site 568703001030 phosphorylation site [posttranslational modification] 568703001031 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703001032 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703001033 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703001034 catalytic residue [active] 568703001035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703001036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001037 DNA binding site [nucleotide binding] 568703001038 domain linker motif; other site 568703001039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 568703001040 dimerization interface [polypeptide binding]; other site 568703001041 ligand binding site [chemical binding]; other site 568703001042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cl15306 568703001044 substrate binding pocket [chemical binding]; other site 568703001045 membrane-bound complex binding site; other site 568703001046 hinge residues; other site 568703001047 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 568703001048 Protein of unknown function; Region: YhfT; pfam10797 568703001049 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 568703001050 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 568703001051 active site 568703001052 substrate binding pocket [chemical binding]; other site 568703001053 homodimer interaction site [polypeptide binding]; other site 568703001054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703001055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703001056 catalytic residue [active] 568703001057 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 568703001058 dimer interface [polypeptide binding]; other site 568703001059 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 568703001060 active site 568703001061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703001062 substrate binding site [chemical binding]; other site 568703001063 catalytic residue [active] 568703001064 putative mutase; Provisional; Region: PRK12383 568703001065 Sulfatase; Region: Sulfatase; cl10460 568703001066 Uncharacterized conserved protein [Function unknown]; Region: COG1912 568703001067 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 568703001068 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 568703001069 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 568703001070 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001071 Walker A/P-loop; other site 568703001072 ATP binding site [chemical binding]; other site 568703001073 Q-loop/lid; other site 568703001074 ABC transporter signature motif; other site 568703001075 Walker B; other site 568703001076 D-loop; other site 568703001077 H-loop/switch region; other site 568703001078 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 568703001079 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703001080 Walker A/P-loop; other site 568703001081 ATP binding site [chemical binding]; other site 568703001082 Q-loop/lid; other site 568703001083 ABC transporter signature motif; other site 568703001084 Walker B; other site 568703001085 D-loop; other site 568703001086 H-loop/switch region; other site 568703001087 Cobalt transport protein; Region: CbiQ; cl00463 568703001088 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 568703001089 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 568703001090 active site 568703001091 octamer interface [polypeptide binding]; other site 568703001092 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 568703001093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001094 Integrase core domain; Region: rve; cl01316 568703001095 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568703001096 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568703001097 catalytic residues [active] 568703001098 catalytic nucleophile [active] 568703001099 Presynaptic Site I dimer interface [polypeptide binding]; other site 568703001100 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568703001101 Synaptic Flat tetramer interface [polypeptide binding]; other site 568703001102 Synaptic Site I dimer interface [polypeptide binding]; other site 568703001103 DNA binding site [nucleotide binding] 568703001104 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 568703001105 Dimer interface [polypeptide binding]; other site 568703001106 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 568703001107 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703001108 active site 568703001109 catalytic site [active] 568703001110 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703001111 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 568703001112 metal ion-dependent adhesion site (MIDAS); other site 568703001113 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 568703001114 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 568703001115 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001116 Integrase core domain; Region: rve; cl01316 568703001117 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703001118 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703001119 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703001120 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 568703001121 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 568703001122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001123 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 568703001124 putative active site [active] 568703001125 putative metal-binding site [ion binding]; other site 568703001126 Transposase domain (DUF772); Region: DUF772; cl12084 568703001127 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 568703001128 putative transposase OrfB; Reviewed; Region: PHA02517 568703001129 Integrase core domain; Region: rve; cl01316 568703001130 putative transposase OrfB; Reviewed; Region: PHA02517 568703001131 Integrase core domain; Region: rve; cl01316 568703001132 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001133 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703001134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001136 active site 568703001137 motif I; other site 568703001138 motif II; other site 568703001139 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001143 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703001144 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 568703001145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 568703001149 Integrase core domain; Region: rve; cl01316 568703001150 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 568703001151 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 568703001152 Cl- selectivity filter; other site 568703001153 Cl- binding residues [ion binding]; other site 568703001154 pore gating glutamate residue; other site 568703001155 dimer interface [polypeptide binding]; other site 568703001156 H+/Cl- coupling transport residue; other site 568703001157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703001158 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 568703001159 Integrase core domain; Region: rve; cl01316 568703001160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001161 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001162 putative substrate translocation pore; other site 568703001163 Transposase domain (DUF772); Region: DUF772; cl12084 568703001164 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 568703001165 M28, and M42; Region: Zinc_peptidase_like; cl14876 568703001166 metal binding site [ion binding]; metal-binding site 568703001167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703001170 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 568703001171 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 568703001172 domain; Region: Glyco_hydro_2; pfam00703 568703001173 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 568703001174 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001175 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001176 Amino acid permease; Region: AA_permease; pfam00324 568703001177 Cupin domain; Region: Cupin_2; cl09118 568703001178 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703001179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 568703001180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703001181 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 568703001182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001183 D-galactonate transporter; Region: 2A0114; TIGR00893 568703001184 putative substrate translocation pore; other site 568703001185 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 568703001186 amidohydrolase; Region: amidohydrolases; TIGR01891 568703001187 putative metal binding site [ion binding]; other site 568703001188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703001189 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 568703001190 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703001191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001192 Walker A/P-loop; other site 568703001193 ATP binding site [chemical binding]; other site 568703001194 Q-loop/lid; other site 568703001195 ABC transporter signature motif; other site 568703001196 Walker B; other site 568703001197 D-loop; other site 568703001198 H-loop/switch region; other site 568703001199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703001200 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703001201 substrate binding pocket [chemical binding]; other site 568703001202 membrane-bound complex binding site; other site 568703001203 hinge residues; other site 568703001204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703001205 dimer interface [polypeptide binding]; other site 568703001206 conserved gate region; other site 568703001207 putative PBP binding loops; other site 568703001208 ABC-ATPase subunit interface; other site 568703001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703001210 dimer interface [polypeptide binding]; other site 568703001211 conserved gate region; other site 568703001212 putative PBP binding loops; other site 568703001213 ABC-ATPase subunit interface; other site 568703001214 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 568703001215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001216 YvrJ protein family; Region: YvrJ; pfam12841 568703001217 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and...; Region: GH25_AtlA-like; cd06522 568703001218 active site 568703001219 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703001220 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 568703001221 putative peptidoglycan binding site; other site 568703001222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703001223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703001224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703001225 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703001226 Walker A/P-loop; other site 568703001227 ATP binding site [chemical binding]; other site 568703001228 Q-loop/lid; other site 568703001229 ABC transporter signature motif; other site 568703001230 Walker B; other site 568703001231 D-loop; other site 568703001232 H-loop/switch region; other site 568703001233 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 568703001234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703001235 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703001236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001237 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703001238 active site 568703001239 motif I; other site 568703001240 motif II; other site 568703001241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703001242 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 568703001243 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 568703001244 Transposase domain (DUF772); Region: DUF772; cl12084 568703001245 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703001246 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 568703001247 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 568703001248 active site 568703001249 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 568703001250 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 568703001251 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 568703001252 DAK2 domain; Region: Dak2; cl03685 568703001253 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 568703001254 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 568703001255 OsmC-like protein; Region: OsmC; cl00767 568703001256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703001257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001258 Walker A/P-loop; other site 568703001259 ATP binding site [chemical binding]; other site 568703001260 Q-loop/lid; other site 568703001261 ABC transporter signature motif; other site 568703001262 Walker B; other site 568703001263 D-loop; other site 568703001264 H-loop/switch region; other site 568703001265 Transposase domain (DUF772); Region: DUF772; cl12084 568703001266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703001267 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001268 Transposase domain (DUF772); Region: DUF772; cl12084 568703001269 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703001270 active site 568703001271 substrate binding site [chemical binding]; other site 568703001272 catalytic site [active] 568703001273 RelB antitoxin; Region: RelB; cl01171 568703001274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703001275 dimerization interface [polypeptide binding]; other site 568703001276 putative DNA binding site [nucleotide binding]; other site 568703001277 putative Zn2+ binding site [ion binding]; other site 568703001278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001279 benzoate transport; Region: 2A0115; TIGR00895 568703001280 putative substrate translocation pore; other site 568703001281 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 568703001282 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703001283 hypothetical protein; Provisional; Region: PRK08185 568703001284 intersubunit interface [polypeptide binding]; other site 568703001285 active site 568703001286 zinc binding site [ion binding]; other site 568703001287 Na+ binding site [ion binding]; other site 568703001288 pyruvate oxidase; Provisional; Region: PRK08611 568703001289 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703001290 PYR/PP interface [polypeptide binding]; other site 568703001291 tetramer interface [polypeptide binding]; other site 568703001292 dimer interface [polypeptide binding]; other site 568703001293 TPP binding site [chemical binding]; other site 568703001294 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703001295 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 568703001296 TPP-binding site [chemical binding]; other site 568703001297 Beta-lactamase; Region: Beta-lactamase; cl01009 568703001298 Beta-lactamase; Region: Beta-lactamase; cl01009 568703001299 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 568703001300 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 568703001301 active site 568703001302 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 568703001303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703001304 S-adenosylmethionine binding site [chemical binding]; other site 568703001305 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 568703001306 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703001307 catalytic triad [active] 568703001308 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 568703001309 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703001310 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703001311 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703001312 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001313 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703001314 DNA binding residues [nucleotide binding] 568703001315 putative dimer interface [polypeptide binding]; other site 568703001316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703001317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001318 active site 568703001319 catalytic tetrad [active] 568703001320 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001321 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001322 putative NAD(P) binding site [chemical binding]; other site 568703001323 dimer interface [polypeptide binding]; other site 568703001324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001325 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 568703001326 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703001327 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568703001328 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703001329 Walker A/P-loop; other site 568703001330 ATP binding site [chemical binding]; other site 568703001331 Q-loop/lid; other site 568703001332 ABC transporter signature motif; other site 568703001333 Walker B; other site 568703001334 D-loop; other site 568703001335 H-loop/switch region; other site 568703001336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703001338 active site 568703001339 phosphorylation site [posttranslational modification] 568703001340 intermolecular recognition site; other site 568703001341 dimerization interface [polypeptide binding]; other site 568703001342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703001343 DNA binding site [nucleotide binding] 568703001344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703001345 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 568703001346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703001347 dimer interface [polypeptide binding]; other site 568703001348 phosphorylation site [posttranslational modification] 568703001349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001350 ATP binding site [chemical binding]; other site 568703001351 Mg2+ binding site [ion binding]; other site 568703001352 G-X-G motif; other site 568703001353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001354 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 568703001355 Walker A/P-loop; other site 568703001356 ATP binding site [chemical binding]; other site 568703001357 Q-loop/lid; other site 568703001358 ABC transporter signature motif; other site 568703001359 Walker B; other site 568703001360 D-loop; other site 568703001361 H-loop/switch region; other site 568703001362 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 568703001363 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 568703001364 Zn binding site [ion binding]; other site 568703001365 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703001366 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001367 putative transporter; Provisional; Region: PRK11462 568703001368 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 568703001369 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 568703001370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001372 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 568703001373 putative dimerization interface [polypeptide binding]; other site 568703001374 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 568703001375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568703001376 classical (c) SDRs; Region: SDR_c; cd05233 568703001377 NAD(P) binding site [chemical binding]; other site 568703001378 active site 568703001379 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001380 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001381 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001382 shikimate binding site; other site 568703001383 NAD(P) binding site [chemical binding]; other site 568703001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001385 putative substrate translocation pore; other site 568703001386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703001387 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 568703001388 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 568703001389 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 568703001390 shikimate binding site; other site 568703001391 NAD(P) binding site [chemical binding]; other site 568703001392 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 568703001393 proposed active site lysine [active] 568703001394 conserved cys residue [active] 568703001395 cysteine synthases; Region: cysKM; TIGR01136 568703001396 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 568703001397 dimer interface [polypeptide binding]; other site 568703001398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001399 catalytic residue [active] 568703001400 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 568703001401 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 568703001402 homodimer interface [polypeptide binding]; other site 568703001403 substrate-cofactor binding pocket; other site 568703001404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703001405 catalytic residue [active] 568703001406 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 568703001407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703001408 substrate binding pocket [chemical binding]; other site 568703001409 membrane-bound complex binding site; other site 568703001410 hinge residues; other site 568703001411 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703001412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703001413 dimer interface [polypeptide binding]; other site 568703001414 conserved gate region; other site 568703001415 putative PBP binding loops; other site 568703001416 ABC-ATPase subunit interface; other site 568703001417 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 568703001418 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703001419 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703001420 legume lectins; Region: lectin_L-type; cd01951 568703001421 homotetramer interaction site [polypeptide binding]; other site 568703001422 homodimer interaction site [polypeptide binding]; other site 568703001423 carbohydrate binding site [chemical binding]; other site 568703001424 metal binding site [ion binding]; metal-binding site 568703001425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703001427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703001428 legume lectins; Region: lectin_L-type; cd01951 568703001429 homotetramer interaction site [polypeptide binding]; other site 568703001430 carbohydrate binding site [chemical binding]; other site 568703001431 metal binding site [ion binding]; metal-binding site 568703001432 EamA-like transporter family; Region: EamA; cl01037 568703001433 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 568703001434 EamA-like transporter family; Region: EamA; cl01037 568703001435 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703001436 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703001437 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703001438 Walker A/P-loop; other site 568703001439 ATP binding site [chemical binding]; other site 568703001440 Q-loop/lid; other site 568703001441 ABC transporter signature motif; other site 568703001442 Walker B; other site 568703001443 D-loop; other site 568703001444 H-loop/switch region; other site 568703001445 Transposase domain (DUF772); Region: DUF772; cl12084 568703001446 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 568703001447 substrate binding site [chemical binding]; other site 568703001448 ATP binding site [chemical binding]; other site 568703001449 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 568703001450 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 568703001451 FAD binding site [chemical binding]; other site 568703001452 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 568703001453 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 568703001454 THF binding site; other site 568703001455 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 568703001456 substrate binding site [chemical binding]; other site 568703001457 THF binding site; other site 568703001458 zinc-binding site [ion binding]; other site 568703001459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001460 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703001461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001462 Walker A/P-loop; other site 568703001463 ATP binding site [chemical binding]; other site 568703001464 Q-loop/lid; other site 568703001465 ABC transporter signature motif; other site 568703001466 Walker B; other site 568703001467 D-loop; other site 568703001468 H-loop/switch region; other site 568703001469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001470 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703001471 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 568703001472 Walker A/P-loop; other site 568703001473 ATP binding site [chemical binding]; other site 568703001474 Q-loop/lid; other site 568703001475 ABC transporter signature motif; other site 568703001476 Walker B; other site 568703001477 D-loop; other site 568703001478 H-loop/switch region; other site 568703001479 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 568703001480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703001481 putative substrate translocation pore; other site 568703001482 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 568703001483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703001484 DNA-binding site [nucleotide binding]; DNA binding site 568703001485 UTRA domain; Region: UTRA; cl01230 568703001486 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703001487 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703001488 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 568703001489 HPr interaction site; other site 568703001490 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703001491 active site 568703001492 phosphorylation site [posttranslational modification] 568703001493 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 568703001494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703001495 active site turn [active] 568703001496 phosphorylation site [posttranslational modification] 568703001497 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703001498 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 568703001499 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001500 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703001501 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703001502 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703001503 NAD binding site [chemical binding]; other site 568703001504 dimer interface [polypeptide binding]; other site 568703001505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703001506 substrate binding site [chemical binding]; other site 568703001507 glutamate dehydrogenase; Provisional; Region: PRK09414 568703001508 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 568703001509 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 568703001510 NAD(P) binding site [chemical binding]; other site 568703001511 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 568703001512 DNA-binding site [nucleotide binding]; DNA binding site 568703001513 RNA-binding motif; other site 568703001514 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 568703001515 OsmC-like protein; Region: OsmC; cl00767 568703001516 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703001517 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703001518 ABC transporter; Region: ABC_tran_2; pfam12848 568703001519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703001520 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 568703001521 NAD(P) binding site [chemical binding]; other site 568703001522 putative active site [active] 568703001523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703001524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001525 active site 568703001526 catalytic tetrad [active] 568703001527 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703001528 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 568703001529 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 568703001530 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 568703001531 LytTr DNA-binding domain; Region: LytTR; cl04498 568703001532 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001534 Walker A/P-loop; other site 568703001535 ATP binding site [chemical binding]; other site 568703001536 Q-loop/lid; other site 568703001537 ABC transporter signature motif; other site 568703001538 Walker B; other site 568703001539 D-loop; other site 568703001540 H-loop/switch region; other site 568703001541 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703001542 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 568703001543 active site 568703001544 zinc binding site [ion binding]; other site 568703001545 Domain of unknown function (DUF74); Region: DUF74; cl00426 568703001546 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 568703001547 putative NADH binding site [chemical binding]; other site 568703001548 putative active site [active] 568703001549 nudix motif; other site 568703001550 putative metal binding site [ion binding]; other site 568703001551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703001553 active site 568703001554 phosphorylation site [posttranslational modification] 568703001555 intermolecular recognition site; other site 568703001556 dimerization interface [polypeptide binding]; other site 568703001557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703001558 DNA binding site [nucleotide binding] 568703001559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 568703001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001561 ATP binding site [chemical binding]; other site 568703001562 Mg2+ binding site [ion binding]; other site 568703001563 G-X-G motif; other site 568703001564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703001565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001566 Walker A/P-loop; other site 568703001567 ATP binding site [chemical binding]; other site 568703001568 Q-loop/lid; other site 568703001569 ABC transporter signature motif; other site 568703001570 Walker B; other site 568703001571 D-loop; other site 568703001572 H-loop/switch region; other site 568703001573 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 568703001574 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703001575 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703001576 putative NAD(P) binding site [chemical binding]; other site 568703001577 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 568703001578 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 568703001579 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 568703001580 MgtC family; Region: MgtC; cl12207 568703001581 streptodornase; Region: PHA01790 568703001582 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 568703001583 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001584 Walker A/P-loop; other site 568703001585 ATP binding site [chemical binding]; other site 568703001586 ABC transporter signature motif; other site 568703001587 Walker B; other site 568703001588 D-loop; other site 568703001589 H-loop/switch region; other site 568703001590 ABC transporter; Region: ABC_tran_2; pfam12848 568703001591 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703001592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001593 ATPase domain of DNA mismatch repair MUTS family; Region: MUTSac; smart00534 568703001594 Walker A/P-loop; other site 568703001595 ATP binding site [chemical binding]; other site 568703001596 Q-loop/lid; other site 568703001597 ABC transporter signature motif; other site 568703001598 Walker B; other site 568703001599 D-loop; other site 568703001600 H-loop/switch region; other site 568703001601 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 568703001602 putative uracil binding site [chemical binding]; other site 568703001603 putative active site [active] 568703001604 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 568703001605 amphipathic channel; other site 568703001606 Asn-Pro-Ala signature motifs; other site 568703001607 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 568703001608 glycerol kinase; Provisional; Region: glpK; PRK00047 568703001609 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703001610 N- and C-terminal domain interface [polypeptide binding]; other site 568703001611 active site 568703001612 MgATP binding site [chemical binding]; other site 568703001613 catalytic site [active] 568703001614 metal binding site [ion binding]; metal-binding site 568703001615 glycerol binding site [chemical binding]; other site 568703001616 homotetramer interface [polypeptide binding]; other site 568703001617 homodimer interface [polypeptide binding]; other site 568703001618 FBP binding site [chemical binding]; other site 568703001619 protein IIAGlc interface [polypeptide binding]; other site 568703001620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 568703001621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703001622 active site 568703001623 PRD domain; Region: PRD; pfam00874 568703001624 PRD domain; Region: PRD; pfam00874 568703001625 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703001626 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 568703001627 P-loop; other site 568703001628 active site 568703001629 phosphorylation site [posttranslational modification] 568703001630 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703001631 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703001632 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703001633 methionine cluster; other site 568703001634 active site 568703001635 phosphorylation site [posttranslational modification] 568703001636 metal binding site [ion binding]; metal-binding site 568703001637 galactokinase; Provisional; Region: PRK05322 568703001638 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 568703001639 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 568703001640 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703001641 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 568703001642 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 568703001643 NAD binding site [chemical binding]; other site 568703001644 homodimer interface [polypeptide binding]; other site 568703001645 active site 568703001646 substrate binding site [chemical binding]; other site 568703001647 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 568703001648 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 568703001649 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 568703001650 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 568703001651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001652 DNA binding site [nucleotide binding] 568703001653 domain linker motif; other site 568703001654 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 568703001655 putative dimerization interface [polypeptide binding]; other site 568703001656 putative ligand binding site [chemical binding]; other site 568703001657 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 568703001658 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 568703001659 active site 568703001660 catalytic residues [active] 568703001661 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703001662 Beta-lactamase; Region: Beta-lactamase; cl01009 568703001663 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703001664 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 568703001665 putative substrate binding site [chemical binding]; other site 568703001666 putative ATP binding site [chemical binding]; other site 568703001667 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703001668 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 568703001669 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 568703001670 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703001671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001672 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703001673 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 568703001674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001675 active site 568703001676 motif I; other site 568703001677 motif II; other site 568703001678 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 568703001679 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 568703001680 active site 568703001681 metal binding site [ion binding]; metal-binding site 568703001682 DNA binding site [nucleotide binding] 568703001683 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 568703001684 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 568703001685 Walker A/P-loop; other site 568703001686 ATP binding site [chemical binding]; other site 568703001687 Q-loop/lid; other site 568703001688 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703001689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001690 ABC transporter signature motif; other site 568703001691 Walker B; other site 568703001692 D-loop; other site 568703001693 H-loop/switch region; other site 568703001694 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703001695 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703001696 putative dimer interface [polypeptide binding]; other site 568703001697 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 568703001698 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703001699 minor groove reading motif; other site 568703001700 helix-hairpin-helix signature motif; other site 568703001701 substrate binding pocket [chemical binding]; other site 568703001702 active site 568703001703 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 568703001704 DNA binding and oxoG recognition site [nucleotide binding] 568703001705 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 568703001706 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703001707 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 568703001708 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 568703001709 dimer interface [polypeptide binding]; other site 568703001710 substrate binding site [chemical binding]; other site 568703001711 ATP binding site [chemical binding]; other site 568703001712 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703001713 NAD binding site [chemical binding]; other site 568703001714 substrate binding site [chemical binding]; other site 568703001715 putative active site [active] 568703001716 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 568703001717 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 568703001718 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 568703001719 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001720 zinc binding site [ion binding]; other site 568703001721 putative ligand binding site [chemical binding]; other site 568703001722 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 568703001723 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703001724 zinc binding site [ion binding]; other site 568703001725 putative ligand binding site [chemical binding]; other site 568703001726 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703001727 TM-ABC transporter signature motif; other site 568703001728 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703001729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001730 Walker A/P-loop; other site 568703001731 ATP binding site [chemical binding]; other site 568703001732 Q-loop/lid; other site 568703001733 ABC transporter signature motif; other site 568703001734 Walker B; other site 568703001735 D-loop; other site 568703001736 H-loop/switch region; other site 568703001737 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 568703001738 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 568703001739 NADP binding site [chemical binding]; other site 568703001740 dimer interface [polypeptide binding]; other site 568703001741 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001742 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703001743 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703001745 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703001746 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703001747 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703001748 Ligand binding site [chemical binding]; other site 568703001749 Putative Catalytic site [active] 568703001750 DXD motif; other site 568703001751 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 568703001752 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 568703001753 GtrA-like protein; Region: GtrA; cl00971 568703001754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703001755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703001756 active site 568703001757 phosphorylation site [posttranslational modification] 568703001758 intermolecular recognition site; other site 568703001759 dimerization interface [polypeptide binding]; other site 568703001760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703001761 DNA binding site [nucleotide binding] 568703001762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703001763 dimer interface [polypeptide binding]; other site 568703001764 phosphorylation site [posttranslational modification] 568703001765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703001766 ATP binding site [chemical binding]; other site 568703001767 Mg2+ binding site [ion binding]; other site 568703001768 G-X-G motif; other site 568703001769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 568703001770 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 568703001771 hypothetical protein; Provisional; Region: PRK06194 568703001772 classical (c) SDRs; Region: SDR_c; cd05233 568703001773 NAD(P) binding site [chemical binding]; other site 568703001774 active site 568703001775 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 568703001776 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703001777 dimer interface [polypeptide binding]; other site 568703001778 FMN binding site [chemical binding]; other site 568703001779 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703001780 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 568703001781 phosphate binding site [ion binding]; other site 568703001782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001783 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 568703001784 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 568703001785 putative NAD(P) binding site [chemical binding]; other site 568703001786 dimer interface [polypeptide binding]; other site 568703001787 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703001788 Domain of unknown function DUF20; Region: UPF0118; cl00465 568703001789 LexA repressor; Validated; Region: PRK00215 568703001790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001791 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 568703001792 Catalytic site [active] 568703001793 Membrane transport protein; Region: Mem_trans; cl09117 568703001794 Flavin Reductases; Region: FlaRed; cl00801 568703001795 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 568703001796 Protein of unknown function, DUF488; Region: DUF488; cl01246 568703001797 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 568703001798 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 568703001799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703001800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001801 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 568703001802 putative dimerization interface [polypeptide binding]; other site 568703001803 malate dehydrogenase; Provisional; Region: PRK13529 568703001804 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703001805 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 568703001806 NAD(P) binding site [chemical binding]; other site 568703001807 Membrane transport protein; Region: Mem_trans; cl09117 568703001808 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 568703001809 dimer interface [polypeptide binding]; other site 568703001810 catalytic triad [active] 568703001811 peroxidatic and resolving cysteines [active] 568703001812 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703001813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703001814 non-specific DNA binding site [nucleotide binding]; other site 568703001815 salt bridge; other site 568703001816 sequence-specific DNA binding site [nucleotide binding]; other site 568703001817 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703001818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703001819 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703001820 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 568703001821 Walker A/P-loop; other site 568703001822 ATP binding site [chemical binding]; other site 568703001823 Q-loop/lid; other site 568703001824 ABC transporter signature motif; other site 568703001825 Walker B; other site 568703001826 D-loop; other site 568703001827 H-loop/switch region; other site 568703001828 oligoendopeptidase F; Region: pepF; TIGR00181 568703001829 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 568703001830 active site 568703001831 Zn binding site [ion binding]; other site 568703001832 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 568703001833 active site 568703001834 multimer interface [polypeptide binding]; other site 568703001835 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703001836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703001837 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703001838 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 568703001839 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703001840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001842 motif II; other site 568703001843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001844 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 568703001845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703001846 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703001847 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703001848 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703001849 active site 568703001850 catalytic tetrad [active] 568703001851 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703001852 Protein of unknown function (DUF421); Region: DUF421; cl00990 568703001853 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 568703001854 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 568703001855 substrate binding site [chemical binding]; other site 568703001856 zinc-binding site [ion binding]; other site 568703001857 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 568703001858 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568703001859 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 568703001860 RuvA N terminal domain; Region: RuvA_N; pfam01330 568703001861 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 568703001862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703001863 Walker A motif; other site 568703001864 ATP binding site [chemical binding]; other site 568703001865 Walker B motif; other site 568703001866 arginine finger; other site 568703001867 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 568703001868 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 568703001869 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 568703001870 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 568703001871 Preprotein translocase subunit; Region: YajC; cl00806 568703001872 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 568703001873 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 568703001874 putative catalytic cysteine [active] 568703001875 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 568703001876 putative active site [active] 568703001877 metal binding site [ion binding]; metal-binding site 568703001878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001879 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 568703001880 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 568703001881 FeoA domain; Region: FeoA; cl00838 568703001882 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 568703001883 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 568703001884 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 568703001885 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 568703001886 active site 568703001887 DNA polymerase IV; Validated; Region: PRK02406 568703001888 DNA binding site [nucleotide binding] 568703001889 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 568703001890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703001891 DNA-binding site [nucleotide binding]; DNA binding site 568703001892 DRTGG domain; Region: DRTGG; cl12147 568703001893 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703001894 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703001895 DHH family; Region: DHH; pfam01368 568703001896 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703001897 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 568703001898 ATP binding site [chemical binding]; other site 568703001899 Mg++ binding site [ion binding]; other site 568703001900 motif III; other site 568703001901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703001902 nucleotide binding region [chemical binding]; other site 568703001903 ATP-binding site [chemical binding]; other site 568703001904 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 568703001905 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 568703001906 motif 1; other site 568703001907 active site 568703001908 motif 2; other site 568703001909 motif 3; other site 568703001910 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 568703001911 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 568703001912 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 568703001913 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 568703001914 Cell division protein ZapA; Region: ZapA; cl01146 568703001915 Colicin V production protein; Region: Colicin_V; cl00567 568703001916 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 568703001917 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703001918 Walker A/P-loop; other site 568703001919 ATP binding site [chemical binding]; other site 568703001920 Q-loop/lid; other site 568703001921 ABC transporter signature motif; other site 568703001922 Walker B; other site 568703001923 D-loop; other site 568703001924 H-loop/switch region; other site 568703001925 Smr domain; Region: Smr; cl02619 568703001926 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703001927 catalytic residues [active] 568703001928 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 568703001929 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 568703001930 MBOAT family; Region: MBOAT; cl00738 568703001931 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 568703001932 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 568703001933 DltD N-terminal region; Region: DltD_N; pfam04915 568703001934 DltD central region; Region: DltD_M; pfam04918 568703001935 DltD C-terminal region; Region: DltD_C; pfam04914 568703001936 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 568703001937 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 568703001938 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 568703001939 active site 568703001940 dimerization interface [polypeptide binding]; other site 568703001941 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 568703001942 active site 568703001943 metal binding site [ion binding]; metal-binding site 568703001944 homotetramer interface [polypeptide binding]; other site 568703001945 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 568703001946 amphipathic channel; other site 568703001947 Asn-Pro-Ala signature motifs; other site 568703001948 FOG: CBS domain [General function prediction only]; Region: COG0517 568703001949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643 568703001950 Domain of unknown function (DUF368); Region: DUF368; cl00893 568703001951 Mechanosensitive ion channel; Region: MS_channel; pfam00924 568703001952 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 568703001953 YtxH-like protein; Region: YtxH; cl02079 568703001954 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 568703001955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703001956 3H domain; Region: 3H; pfam02829 568703001957 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703001958 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703001959 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703001960 active site 568703001961 catabolite control protein A; Region: ccpA; TIGR01481 568703001962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703001963 DNA binding site [nucleotide binding] 568703001964 domain linker motif; other site 568703001965 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 568703001966 dimerization interface [polypeptide binding]; other site 568703001967 effector binding site; other site 568703001968 Transglycosylase; Region: Transgly; cl07896 568703001969 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703001970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703001971 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 568703001972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001973 motif II; other site 568703001974 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 568703001975 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568703001976 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 568703001977 dipeptidase PepV; Reviewed; Region: PRK07318 568703001978 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703001979 active site 568703001980 metal binding site [ion binding]; metal-binding site 568703001981 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 568703001982 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 568703001983 active site 568703001984 catalytic site [active] 568703001985 metal binding site [ion binding]; metal-binding site 568703001986 YibE/F-like protein; Region: YibE_F; cl02259 568703001987 YibE/F-like protein; Region: YibE_F; cl02259 568703001988 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 568703001989 putative active site [active] 568703001990 putative metal binding site [ion binding]; other site 568703001991 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 568703001992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703001993 active site 568703001994 metal binding site [ion binding]; metal-binding site 568703001995 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703001996 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 568703001997 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 568703001998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703001999 active site 568703002000 motif I; other site 568703002001 motif II; other site 568703002002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703002003 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 568703002004 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 568703002005 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 568703002006 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 568703002007 tetramer interfaces [polypeptide binding]; other site 568703002008 binuclear metal-binding site [ion binding]; other site 568703002009 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 568703002010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002012 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 568703002013 active site 568703002014 general stress protein 13; Validated; Region: PRK08059 568703002015 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 568703002016 RNA binding site [nucleotide binding]; other site 568703002017 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 568703002018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703002019 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703002020 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703002021 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703002022 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 568703002023 putative ADP-binding pocket [chemical binding]; other site 568703002024 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703002025 Predicted integral membrane protein [Function unknown]; Region: COG0392 568703002026 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 568703002027 hypothetical protein; Validated; Region: PRK07682 568703002028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002030 homodimer interface [polypeptide binding]; other site 568703002031 catalytic residue [active] 568703002032 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 568703002033 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002034 Sulfatase; Region: Sulfatase; cl10460 568703002035 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703002036 metal binding site 2 [ion binding]; metal-binding site 568703002037 putative DNA binding helix; other site 568703002038 metal binding site 1 [ion binding]; metal-binding site 568703002039 dimer interface [polypeptide binding]; other site 568703002040 structural Zn2+ binding site [ion binding]; other site 568703002041 S-adenosylmethionine synthetase; Validated; Region: PRK05250 568703002042 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 568703002043 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 568703002044 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 568703002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002047 putative substrate translocation pore; other site 568703002048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002049 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703002050 DNA binding residues [nucleotide binding] 568703002051 putative dimer interface [polypeptide binding]; other site 568703002052 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703002053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002054 putative substrate translocation pore; other site 568703002055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002056 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 568703002057 active site 568703002058 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 568703002059 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002060 HIGH motif; other site 568703002061 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 568703002062 active site 568703002063 KMSKS motif; other site 568703002064 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 568703002065 tRNA binding surface [nucleotide binding]; other site 568703002066 MatE; Region: MatE; cl10513 568703002067 stage V sporulation protein B; Region: spore_V_B; TIGR02900 568703002068 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703002069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002070 RNA binding surface [nucleotide binding]; other site 568703002071 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 568703002072 active site 568703002073 uracil binding [chemical binding]; other site 568703002074 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 568703002075 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 568703002076 putative substrate binding site [chemical binding]; other site 568703002077 putative ATP binding site [chemical binding]; other site 568703002078 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684 568703002079 nudix motif; other site 568703002080 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 568703002081 catalytic residues [active] 568703002082 dimer interface [polypeptide binding]; other site 568703002083 aspartate aminotransferase; Provisional; Region: PRK08361 568703002084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703002085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703002086 homodimer interface [polypeptide binding]; other site 568703002087 catalytic residue [active] 568703002088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703002089 active site 568703002090 metal binding site [ion binding]; metal-binding site 568703002091 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 568703002092 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 568703002093 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 568703002094 Competence protein CoiA-like family; Region: CoiA; cl11541 568703002095 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703002096 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 568703002097 putative active site [active] 568703002098 putative metal binding residues [ion binding]; other site 568703002099 signature motif; other site 568703002100 putative triphosphate binding site [ion binding]; other site 568703002101 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703002102 synthetase active site [active] 568703002103 NTP binding site [chemical binding]; other site 568703002104 metal binding site [ion binding]; metal-binding site 568703002105 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 568703002106 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703002107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002108 RNA binding surface [nucleotide binding]; other site 568703002109 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 568703002110 active site 568703002111 ApbE family; Region: ApbE; cl00643 568703002112 CutC family; Region: CutC; cl01218 568703002113 Bacitracin resistance protein BacA; Region: BacA; cl00858 568703002114 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 568703002115 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 568703002116 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 568703002117 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 568703002118 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 568703002119 active site 568703002120 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 568703002121 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 568703002122 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 568703002123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703002124 S-adenosylmethionine binding site [chemical binding]; other site 568703002125 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 568703002126 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 568703002127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703002129 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 568703002130 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002131 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002132 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 568703002133 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 568703002134 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 568703002135 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568703002136 classical (c) SDRs; Region: SDR_c; cd05233 568703002137 NAD(P) binding site [chemical binding]; other site 568703002138 active site 568703002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703002140 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 568703002141 competence damage-inducible protein A; Provisional; Region: PRK00549 568703002142 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 568703002143 putative MPT binding site; other site 568703002144 Competence-damaged protein; Region: CinA; cl00666 568703002145 recombinase A; Provisional; Region: recA; PRK09354 568703002146 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703002147 hexamer interface [polypeptide binding]; other site 568703002148 Walker A motif; other site 568703002149 ATP binding site [chemical binding]; other site 568703002150 Walker B motif; other site 568703002151 phosphodiesterase; Provisional; Region: PRK12704 568703002152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703002153 Uncharacterized conserved protein [Function unknown]; Region: COG1739 568703002154 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 568703002155 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 568703002156 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 568703002157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002158 ATP binding site [chemical binding]; other site 568703002159 putative Mg++ binding site [ion binding]; other site 568703002160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002161 nucleotide binding region [chemical binding]; other site 568703002162 ATP-binding site [chemical binding]; other site 568703002163 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 568703002164 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703002165 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 568703002166 30S subunit binding site; other site 568703002167 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 568703002168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002169 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 568703002170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002171 nucleotide binding region [chemical binding]; other site 568703002172 ATP-binding site [chemical binding]; other site 568703002173 peptide chain release factor 2; Provisional; Region: PRK05589 568703002174 RF-1 domain; Region: RF-1; cl02875 568703002175 RF-1 domain; Region: RF-1; cl02875 568703002176 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 568703002177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002178 Walker A/P-loop; other site 568703002179 ATP binding site [chemical binding]; other site 568703002180 Q-loop/lid; other site 568703002181 ABC transporter signature motif; other site 568703002182 Walker B; other site 568703002183 D-loop; other site 568703002184 H-loop/switch region; other site 568703002185 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 568703002186 FtsX-like permease family; Region: FtsX; pfam02687 568703002187 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 568703002188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703002190 active site 568703002191 phosphorylation site [posttranslational modification] 568703002192 intermolecular recognition site; other site 568703002193 dimerization interface [polypeptide binding]; other site 568703002194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703002195 DNA binding site [nucleotide binding] 568703002196 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 568703002197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703002198 dimer interface [polypeptide binding]; other site 568703002199 phosphorylation site [posttranslational modification] 568703002200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002201 ATP binding site [chemical binding]; other site 568703002202 Mg2+ binding site [ion binding]; other site 568703002203 G-X-G motif; other site 568703002204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703002205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002206 dimer interface [polypeptide binding]; other site 568703002207 conserved gate region; other site 568703002208 putative PBP binding loops; other site 568703002209 ABC-ATPase subunit interface; other site 568703002210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 568703002211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002212 dimer interface [polypeptide binding]; other site 568703002213 conserved gate region; other site 568703002214 putative PBP binding loops; other site 568703002215 ABC-ATPase subunit interface; other site 568703002216 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 568703002217 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 568703002218 Walker A/P-loop; other site 568703002219 ATP binding site [chemical binding]; other site 568703002220 Q-loop/lid; other site 568703002221 ABC transporter signature motif; other site 568703002222 Walker B; other site 568703002223 D-loop; other site 568703002224 H-loop/switch region; other site 568703002225 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 568703002226 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 568703002227 Walker A/P-loop; other site 568703002228 ATP binding site [chemical binding]; other site 568703002229 Q-loop/lid; other site 568703002230 ABC transporter signature motif; other site 568703002231 Walker B; other site 568703002232 D-loop; other site 568703002233 H-loop/switch region; other site 568703002234 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 568703002235 PhoU domain; Region: PhoU; pfam01895 568703002236 PhoU domain; Region: PhoU; pfam01895 568703002237 Integrase core domain; Region: rve; cl01316 568703002238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 568703002239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703002240 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703002241 Uncharacterized conserved protein [Function unknown]; Region: COG3595 568703002242 Membrane protein of unknown function; Region: DUF360; cl00850 568703002243 HPr kinase/phosphorylase; Provisional; Region: PRK05428 568703002244 DRTGG domain; Region: DRTGG; cl12147 568703002245 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 568703002246 Hpr binding site; other site 568703002247 active site 568703002248 homohexamer subunit interaction site [polypeptide binding]; other site 568703002249 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 568703002250 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 568703002251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002252 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 568703002253 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 568703002254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002256 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 568703002257 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 568703002258 active site 568703002259 substrate binding site [chemical binding]; other site 568703002260 metal binding site [ion binding]; metal-binding site 568703002261 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703002262 excinuclease ABC subunit B; Provisional; Region: PRK05298 568703002263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002264 ATP binding site [chemical binding]; other site 568703002265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002266 nucleotide binding region [chemical binding]; other site 568703002267 ATP-binding site [chemical binding]; other site 568703002268 Ultra-violet resistance protein B; Region: UvrB; pfam12344 568703002269 UvrB/uvrC motif; Region: UVR; pfam02151 568703002270 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 568703002271 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 568703002272 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 568703002273 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 568703002274 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 568703002275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002276 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 568703002277 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 568703002278 phosphate binding site [ion binding]; other site 568703002279 putative substrate binding pocket [chemical binding]; other site 568703002280 dimer interface [polypeptide binding]; other site 568703002281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 568703002282 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 568703002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703002284 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 568703002285 oligomer interface [polypeptide binding]; other site 568703002286 active site residues [active] 568703002287 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 568703002288 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 568703002289 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 568703002290 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 568703002291 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 568703002292 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 568703002293 substrate binding site [chemical binding]; other site 568703002294 hinge regions; other site 568703002295 ADP binding site [chemical binding]; other site 568703002296 catalytic site [active] 568703002297 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 568703002298 substrate binding site [chemical binding]; other site 568703002299 dimer interface [polypeptide binding]; other site 568703002300 catalytic triad [active] 568703002301 enolase; Provisional; Region: eno; PRK00077 568703002302 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 568703002303 dimer interface [polypeptide binding]; other site 568703002304 metal binding site [ion binding]; metal-binding site 568703002305 substrate binding pocket [chemical binding]; other site 568703002306 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 568703002307 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 568703002308 Cl- selectivity filter; other site 568703002309 Cl- binding residues [ion binding]; other site 568703002310 pore gating glutamate residue; other site 568703002311 dimer interface [polypeptide binding]; other site 568703002312 H+/Cl- coupling transport residue; other site 568703002313 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703002314 Preprotein translocase SecG subunit; Region: SecG; cl09123 568703002315 Esterase/lipase [General function prediction only]; Region: COG1647 568703002316 ribonuclease R; Region: RNase_R; TIGR02063 568703002317 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 568703002318 RNB domain; Region: RNB; pfam00773 568703002319 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 568703002320 RNA binding site [nucleotide binding]; other site 568703002321 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 568703002322 SmpB-tmRNA interface; other site 568703002323 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 568703002324 homodimer; other site 568703002325 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703002326 maltose phosphorylase; Provisional; Region: PRK13807 568703002327 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 568703002328 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 568703002329 beta-phosphoglucomutase; Region: bPGM; TIGR01990 568703002330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703002332 motif II; other site 568703002333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002334 sequence-specific DNA binding site [nucleotide binding]; other site 568703002335 salt bridge; other site 568703002336 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703002337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703002338 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703002339 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703002340 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703002341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703002342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703002343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002344 dimer interface [polypeptide binding]; other site 568703002345 conserved gate region; other site 568703002346 putative PBP binding loops; other site 568703002347 ABC-ATPase subunit interface; other site 568703002348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002349 dimer interface [polypeptide binding]; other site 568703002350 conserved gate region; other site 568703002351 putative PBP binding loops; other site 568703002352 ABC-ATPase subunit interface; other site 568703002353 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 568703002354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002355 Walker A/P-loop; other site 568703002356 ATP binding site [chemical binding]; other site 568703002357 Q-loop/lid; other site 568703002358 ABC transporter signature motif; other site 568703002359 Walker B; other site 568703002360 D-loop; other site 568703002361 H-loop/switch region; other site 568703002362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703002363 Scramblase; Region: Scramblase; cl02043 568703002364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703002365 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002366 active site 568703002367 motif I; other site 568703002368 motif II; other site 568703002369 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 568703002370 ligand binding site [chemical binding]; other site 568703002371 active site 568703002372 UGI interface [polypeptide binding]; other site 568703002373 catalytic site [active] 568703002374 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 568703002375 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 568703002376 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 568703002377 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703002378 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 568703002379 Walker A/P-loop; other site 568703002380 ATP binding site [chemical binding]; other site 568703002381 Q-loop/lid; other site 568703002382 ABC transporter signature motif; other site 568703002383 Walker B; other site 568703002384 D-loop; other site 568703002385 H-loop/switch region; other site 568703002386 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002387 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 568703002388 active site 568703002389 substrate binding site [chemical binding]; other site 568703002390 catalytic site [active] 568703002391 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 568703002392 active site 568703002393 DNA binding site [nucleotide binding] 568703002394 putative phosphate binding site [ion binding]; other site 568703002395 putative catalytic site [active] 568703002396 metal binding site A [ion binding]; metal-binding site 568703002397 AP binding site [nucleotide binding]; other site 568703002398 metal binding site B [ion binding]; metal-binding site 568703002399 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703002400 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 568703002401 FAD binding domain; Region: FAD_binding_4; pfam01565 568703002402 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 568703002403 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 568703002404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002405 non-specific DNA binding site [nucleotide binding]; other site 568703002406 salt bridge; other site 568703002407 sequence-specific DNA binding site [nucleotide binding]; other site 568703002408 Cupin domain; Region: Cupin_2; cl09118 568703002409 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 568703002410 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 568703002411 Walker A/P-loop; other site 568703002412 ATP binding site [chemical binding]; other site 568703002413 Q-loop/lid; other site 568703002414 ABC transporter signature motif; other site 568703002415 Walker B; other site 568703002416 D-loop; other site 568703002417 H-loop/switch region; other site 568703002418 TOBE domain; Region: TOBE_2; cl01440 568703002419 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002421 dimer interface [polypeptide binding]; other site 568703002422 conserved gate region; other site 568703002423 putative PBP binding loops; other site 568703002424 ABC-ATPase subunit interface; other site 568703002425 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 568703002426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703002427 dimer interface [polypeptide binding]; other site 568703002428 conserved gate region; other site 568703002429 putative PBP binding loops; other site 568703002430 ABC-ATPase subunit interface; other site 568703002431 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 568703002432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703002433 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703002434 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703002435 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703002436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703002437 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703002438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002440 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703002441 ABC-2 type transporter; Region: ABC2_membrane; cl11417 568703002442 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703002443 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 568703002444 Walker A/P-loop; other site 568703002445 ATP binding site [chemical binding]; other site 568703002446 Q-loop/lid; other site 568703002447 ABC transporter signature motif; other site 568703002448 Walker B; other site 568703002449 D-loop; other site 568703002450 H-loop/switch region; other site 568703002451 Uncharacterized conserved protein [Function unknown]; Region: COG1624 568703002452 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 568703002453 YbbR-like protein; Region: YbbR; pfam07949 568703002454 YbbR-like protein; Region: YbbR; pfam07949 568703002455 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 568703002456 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 568703002457 active site 568703002458 substrate binding site [chemical binding]; other site 568703002459 metal binding site [ion binding]; metal-binding site 568703002460 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 568703002461 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 568703002462 glutaminase active site [active] 568703002463 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 568703002464 dimer interface [polypeptide binding]; other site 568703002465 active site 568703002466 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 568703002467 dimer interface [polypeptide binding]; other site 568703002468 active site 568703002469 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 568703002470 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 568703002471 active site 568703002472 Zn binding site [ion binding]; other site 568703002473 VanZ like family; Region: VanZ; cl01971 568703002474 Domain of unknown function DUF28; Region: DUF28; cl00361 568703002475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002476 Walker A motif; other site 568703002477 ATP binding site [chemical binding]; other site 568703002478 Walker B motif; other site 568703002479 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 568703002480 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 568703002481 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 568703002482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703002483 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703002484 Amino acid permease; Region: AA_permease; pfam00324 568703002485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703002486 putative acyl-acceptor binding pocket; other site 568703002487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703002488 active site 568703002489 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 568703002490 Ligand binding site [chemical binding]; other site 568703002491 metal binding site [ion binding]; metal-binding site 568703002492 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703002493 putative acyl-acceptor binding pocket; other site 568703002494 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703002495 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 568703002496 catalytic site [active] 568703002497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703002499 active site 568703002500 phosphorylation site [posttranslational modification] 568703002501 intermolecular recognition site; other site 568703002502 dimerization interface [polypeptide binding]; other site 568703002503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703002504 DNA binding site [nucleotide binding] 568703002505 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 568703002506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703002507 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 568703002508 dimerization interface [polypeptide binding]; other site 568703002509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703002510 dimer interface [polypeptide binding]; other site 568703002511 phosphorylation site [posttranslational modification] 568703002512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002513 ATP binding site [chemical binding]; other site 568703002514 Mg2+ binding site [ion binding]; other site 568703002515 G-X-G motif; other site 568703002516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703002517 hypothetical protein; Provisional; Region: PRK04435 568703002518 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 568703002519 DNA polymerase IV; Reviewed; Region: PRK03103 568703002520 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 568703002521 active site 568703002522 DNA binding site [nucleotide binding] 568703002523 Predicted membrane protein [Function unknown]; Region: COG4640 568703002524 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 568703002525 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 568703002526 active site 568703002527 catalytic triad [active] 568703002528 oxyanion hole [active] 568703002529 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 568703002530 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 568703002531 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703002532 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 568703002533 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 568703002534 nucleotide binding pocket [chemical binding]; other site 568703002535 K-X-D-G motif; other site 568703002536 catalytic site [active] 568703002537 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 568703002538 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 568703002539 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 568703002540 Dimer interface [polypeptide binding]; other site 568703002541 BRCT sequence motif; other site 568703002542 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 568703002543 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 568703002544 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 568703002545 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 568703002546 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 568703002547 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 568703002548 GatB domain; Region: GatB_Yqey; cl11497 568703002549 putative lipid kinase; Reviewed; Region: PRK13055 568703002550 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 568703002551 TRAM domain; Region: TRAM; cl01282 568703002552 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703002553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703002554 S-adenosylmethionine binding site [chemical binding]; other site 568703002555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703002556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703002557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703002558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703002559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703002560 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 568703002561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002562 Transposase domain (DUF772); Region: DUF772; cl12084 568703002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703002565 putative substrate translocation pore; other site 568703002566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703002567 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703002568 active site 568703002569 motif I; other site 568703002570 motif II; other site 568703002571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703002572 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 568703002573 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703002574 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703002575 active site 568703002576 Zn binding site [ion binding]; other site 568703002577 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568703002578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002579 Coenzyme A binding pocket [chemical binding]; other site 568703002580 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 568703002581 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 568703002582 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the...; Region: GH25_muramidase_2; cd06419 568703002583 active site 568703002584 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002585 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703002586 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002588 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 568703002589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002590 ATP binding site [chemical binding]; other site 568703002591 putative Mg++ binding site [ion binding]; other site 568703002592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002593 nucleotide binding region [chemical binding]; other site 568703002594 ATP-binding site [chemical binding]; other site 568703002595 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 568703002596 active site 568703002597 methionine cluster; other site 568703002598 phosphorylation site [posttranslational modification] 568703002599 metal binding site [ion binding]; metal-binding site 568703002600 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 568703002601 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703002602 active site 568703002603 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 568703002604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703002605 ATP binding site [chemical binding]; other site 568703002606 putative Mg++ binding site [ion binding]; other site 568703002607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703002608 nucleotide binding region [chemical binding]; other site 568703002609 ATP-binding site [chemical binding]; other site 568703002610 RQC domain; Region: RQC; cl09632 568703002611 HRDC domain; Region: HRDC; cl02578 568703002612 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 568703002613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002615 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 568703002616 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 568703002617 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703002618 methionine aminopeptidase; Reviewed; Region: PRK07281 568703002619 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 568703002620 active site 568703002621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 568703002622 active site 568703002623 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 568703002624 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 568703002625 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 568703002626 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 568703002627 active site 568703002628 tetramer interface [polypeptide binding]; other site 568703002629 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 568703002630 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703002631 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703002632 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703002633 active site turn [active] 568703002634 phosphorylation site [posttranslational modification] 568703002635 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703002636 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 568703002637 HPr interaction site; other site 568703002638 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703002639 active site 568703002640 phosphorylation site [posttranslational modification] 568703002641 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002642 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703002643 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 568703002644 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 568703002645 Ligand binding site [chemical binding]; other site 568703002646 Putative Catalytic site [active] 568703002647 DXD motif; other site 568703002648 Predicted membrane protein [Function unknown]; Region: COG4129 568703002649 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 568703002650 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 568703002651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 568703002652 DNA-binding site [nucleotide binding]; DNA binding site 568703002653 RNA-binding motif; other site 568703002654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703002655 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 568703002656 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703002657 Permease family; Region: Xan_ur_permease; pfam00860 568703002658 Sulfate transporter family; Region: Sulfate_transp; cl00967 568703002659 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568703002660 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703002661 adenylosuccinate lyase; Provisional; Region: PRK07492 568703002662 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 568703002663 tetramer interface [polypeptide binding]; other site 568703002664 active site 568703002665 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 568703002666 Sulfatase; Region: Sulfatase; cl10460 568703002667 VanZ like family; Region: VanZ; cl01971 568703002668 Sugar transport protein; Region: Sugar_transport; pfam06800 568703002669 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 568703002670 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 568703002671 active site 568703002672 dimer interface [polypeptide binding]; other site 568703002673 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 568703002674 dimer interface [polypeptide binding]; other site 568703002675 active site 568703002676 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703002677 Phage integrase family; Region: Phage_integrase; pfam00589 568703002678 Int/Topo IB signature motif; other site 568703002679 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 568703002680 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 568703002681 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 568703002682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002683 non-specific DNA binding site [nucleotide binding]; other site 568703002684 salt bridge; other site 568703002685 sequence-specific DNA binding site [nucleotide binding]; other site 568703002686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002687 non-specific DNA binding site [nucleotide binding]; other site 568703002688 salt bridge; other site 568703002689 sequence-specific DNA binding site [nucleotide binding]; other site 568703002690 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 568703002691 RecT family; Region: RecT; cl04285 568703002692 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 568703002693 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 568703002694 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703002695 dimer interface [polypeptide binding]; other site 568703002696 ssDNA binding site [nucleotide binding]; other site 568703002697 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703002698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703002699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002700 non-specific DNA binding site [nucleotide binding]; other site 568703002701 salt bridge; other site 568703002702 sequence-specific DNA binding site [nucleotide binding]; other site 568703002703 Endodeoxyribonuclease RusA; Region: RusA; cl01885 568703002704 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 568703002705 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 568703002706 GcrA cell cycle regulator; Region: GcrA; cl11564 568703002707 NUMOD4 motif; Region: NUMOD4; pfam07463 568703002708 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703002709 Terminase small subunit; Region: Terminase_2; cl01513 568703002710 Phage terminase large subunit; Region: Terminase_3; cl12054 568703002711 Terminase-like family; Region: Terminase_6; pfam03237 568703002712 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 568703002713 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 568703002714 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 568703002715 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 568703002716 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 568703002717 Phage major tail protein 2; Region: Phage_tail_2; cl11463 568703002718 Phage protein; Region: DUF3647; cl10335 568703002719 Phage-related protein [Function unknown]; Region: COG5412 568703002720 Phage tail protein; Region: Sipho_tail; cl11462 568703002721 Phage tail protein; Region: Sipho_tail; cl11462 568703002722 Phage tail protein; Region: Sipho_tail; cl11462 568703002723 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703002724 Bacteriophage holin; Region: Phage_holin_1; cl02344 568703002725 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703002726 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703002727 active site 568703002728 autolysin; Reviewed; Region: PRK06347 568703002729 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 568703002730 putative peptidoglycan binding site; other site 568703002731 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 568703002732 putative peptidoglycan binding site; other site 568703002733 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 568703002734 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 568703002735 streptodornase; Region: PHA01790 568703002736 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703002737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703002738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002739 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703002740 nucleoside/Zn binding site; other site 568703002741 dimer interface [polypeptide binding]; other site 568703002742 catalytic motif [active] 568703002743 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703002744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703002746 Peptidase family C69; Region: Peptidase_C69; cl01920 568703002747 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 568703002748 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703002749 catalytic core [active] 568703002750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703002751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703002752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002753 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703002754 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002755 Walker A/P-loop; other site 568703002756 ATP binding site [chemical binding]; other site 568703002757 Q-loop/lid; other site 568703002758 ABC transporter signature motif; other site 568703002759 Walker B; other site 568703002760 D-loop; other site 568703002761 H-loop/switch region; other site 568703002762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703002763 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703002764 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 568703002765 Walker A/P-loop; other site 568703002766 ATP binding site [chemical binding]; other site 568703002767 Q-loop/lid; other site 568703002768 ABC transporter signature motif; other site 568703002769 Walker B; other site 568703002770 D-loop; other site 568703002771 H-loop/switch region; other site 568703002772 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703002773 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 568703002774 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703002775 active site 568703002776 metal binding site [ion binding]; metal-binding site 568703002777 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 568703002778 active site 568703002779 metal binding site [ion binding]; metal-binding site 568703002780 Beta-lactamase; Region: Beta-lactamase; cl01009 568703002781 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 568703002782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703002783 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 568703002784 Thymidine kinase; Region: TK; cl00631 568703002785 peptide chain release factor 1; Validated; Region: prfA; PRK00591 568703002786 RF-1 domain; Region: RF-1; cl02875 568703002787 RF-1 domain; Region: RF-1; cl02875 568703002788 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 568703002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703002790 S-adenosylmethionine binding site [chemical binding]; other site 568703002791 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 568703002792 SUA5 domain; Region: SUA5; pfam03481 568703002793 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 568703002794 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 568703002795 dimer interface [polypeptide binding]; other site 568703002796 glycine-pyridoxal phosphate binding site [chemical binding]; other site 568703002797 active site 568703002798 folate binding site [chemical binding]; other site 568703002799 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703002800 ATP synthase A chain; Region: ATP-synt_A; cl00413 568703002801 ATP synthase subunit C; Region: ATP-synt_C; cl00466 568703002802 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 568703002803 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 568703002804 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 568703002805 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 568703002806 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 568703002807 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 568703002808 beta subunit interaction interface [polypeptide binding]; other site 568703002809 Walker A motif; other site 568703002810 ATP binding site [chemical binding]; other site 568703002811 Walker B motif; other site 568703002812 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703002813 ATP synthase; Region: ATP-synt; cl00365 568703002814 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 568703002815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 568703002816 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 568703002817 alpha subunit interaction interface [polypeptide binding]; other site 568703002818 Walker A motif; other site 568703002819 ATP binding site [chemical binding]; other site 568703002820 Walker B motif; other site 568703002821 inhibitor binding site; inhibition site 568703002822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 568703002823 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 568703002824 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 568703002825 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 568703002826 rod shape-determining protein MreB; Provisional; Region: PRK13930 568703002827 Cell division protein FtsA; Region: FtsA; cl11496 568703002828 Domain of unknown function DUF37; Region: DUF37; cl00506 568703002829 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 568703002830 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 568703002831 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 568703002832 lipoyl attachment site [posttranslational modification]; other site 568703002833 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703002834 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703002835 metal binding site [ion binding]; metal-binding site 568703002836 dimer interface [polypeptide binding]; other site 568703002837 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703002838 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703002839 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 568703002840 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 568703002841 Walker A/P-loop; other site 568703002842 ATP binding site [chemical binding]; other site 568703002843 Q-loop/lid; other site 568703002844 ABC transporter signature motif; other site 568703002845 Walker B; other site 568703002846 D-loop; other site 568703002847 H-loop/switch region; other site 568703002848 NIL domain; Region: NIL; cl09633 568703002849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 568703002850 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 568703002851 FeS assembly ATPase SufC; Region: sufC; TIGR01978 568703002852 Walker A/P-loop; other site 568703002853 ATP binding site [chemical binding]; other site 568703002854 Q-loop/lid; other site 568703002855 ABC transporter signature motif; other site 568703002856 Walker B; other site 568703002857 D-loop; other site 568703002858 H-loop/switch region; other site 568703002859 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 568703002860 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 568703002861 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 568703002862 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 568703002863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703002864 catalytic residue [active] 568703002865 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 568703002866 trimerization site [polypeptide binding]; other site 568703002867 active site 568703002868 FeS assembly protein SufB; Region: sufB; TIGR01980 568703002869 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 568703002870 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 568703002871 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 568703002872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703002873 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703002874 Ligand Binding Site [chemical binding]; other site 568703002875 recombination factor protein RarA; Reviewed; Region: PRK13342 568703002876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703002877 Walker A motif; other site 568703002878 ATP binding site [chemical binding]; other site 568703002879 Walker B motif; other site 568703002880 arginine finger; other site 568703002881 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 568703002882 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 568703002883 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 568703002884 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 568703002885 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 568703002886 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 568703002887 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 568703002888 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 568703002889 putative L-serine binding site [chemical binding]; other site 568703002890 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 568703002891 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 568703002892 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703002893 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703002894 catalytic core [active] 568703002895 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 568703002896 short chain dehydrogenase; Provisional; Region: PRK06197 568703002897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703002898 NAD(P) binding site [chemical binding]; other site 568703002899 active site 568703002900 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 568703002901 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 568703002902 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 568703002903 Substrate-binding site [chemical binding]; other site 568703002904 Substrate specificity [chemical binding]; other site 568703002905 hypothetical protein; Provisional; Region: PRK07329 568703002906 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703002907 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703002908 peptide binding site [polypeptide binding]; other site 568703002909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 568703002910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703002911 ATP binding site [chemical binding]; other site 568703002912 Mg2+ binding site [ion binding]; other site 568703002913 G-X-G motif; other site 568703002914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703002915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703002916 active site 568703002917 phosphorylation site [posttranslational modification] 568703002918 intermolecular recognition site; other site 568703002919 dimerization interface [polypeptide binding]; other site 568703002920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703002921 DNA binding site [nucleotide binding] 568703002922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703002923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703002924 Walker A/P-loop; other site 568703002925 ATP binding site [chemical binding]; other site 568703002926 Q-loop/lid; other site 568703002927 ABC transporter signature motif; other site 568703002928 Walker B; other site 568703002929 D-loop; other site 568703002930 H-loop/switch region; other site 568703002931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703002932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703002933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703002934 dimerization interface [polypeptide binding]; other site 568703002935 Cupin domain; Region: Cupin_2; cl09118 568703002936 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568703002937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002938 Coenzyme A binding pocket [chemical binding]; other site 568703002939 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703002940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002941 Coenzyme A binding pocket [chemical binding]; other site 568703002942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703002943 Coenzyme A binding pocket [chemical binding]; other site 568703002944 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 568703002945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703002946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703002947 active site 568703002948 phosphorylation site [posttranslational modification] 568703002949 intermolecular recognition site; other site 568703002950 dimerization interface [polypeptide binding]; other site 568703002951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 568703002952 DNA binding residues [nucleotide binding] 568703002953 dimerization interface [polypeptide binding]; other site 568703002954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 568703002955 Histidine kinase; Region: HisKA_3; pfam07730 568703002956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568703002957 ABC-2 type transporter; Region: ABC2_membrane; cl11417 568703002958 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703002959 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703002960 Walker A/P-loop; other site 568703002961 ATP binding site [chemical binding]; other site 568703002962 Q-loop/lid; other site 568703002963 ABC transporter signature motif; other site 568703002964 Walker B; other site 568703002965 D-loop; other site 568703002966 H-loop/switch region; other site 568703002967 TIGR02680 family protein; Region: TIGR02680 568703002968 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 568703002969 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 568703002970 Transposase domain (DUF772); Region: DUF772; cl12084 568703002971 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 568703002972 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 568703002973 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 568703002974 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 568703002975 RNA binding site [nucleotide binding]; other site 568703002976 Peptidase C26; Region: Peptidase_C26; pfam07722 568703002977 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 568703002978 catalytic triad [active] 568703002979 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703002980 Predicted transcriptional regulator [Transcription]; Region: COG1395 568703002981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703002982 non-specific DNA binding site [nucleotide binding]; other site 568703002983 salt bridge; other site 568703002984 sequence-specific DNA binding site [nucleotide binding]; other site 568703002985 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 568703002986 G1 box; other site 568703002987 GTP/Mg2+ binding site [chemical binding]; other site 568703002988 G2 box; other site 568703002989 Switch I region; other site 568703002990 G3 box; other site 568703002991 Switch II region; other site 568703002992 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 568703002993 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 568703002994 putative active site [active] 568703002995 catalytic site [active] 568703002996 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 568703002997 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 568703002998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703002999 RNA binding surface [nucleotide binding]; other site 568703003000 GAF domain; Region: GAF; cl00853 568703003001 septation ring formation regulator EzrA; Provisional; Region: PRK04778 568703003002 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703003003 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 568703003004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003005 catalytic residue [active] 568703003006 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 568703003007 THUMP domain; Region: THUMP; cl12076 568703003008 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 568703003009 Ligand Binding Site [chemical binding]; other site 568703003010 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703003011 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703003012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003013 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 568703003014 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003015 active site 568703003016 HIGH motif; other site 568703003017 nucleotide binding site [chemical binding]; other site 568703003018 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 568703003019 active site 568703003020 KMSKS motif; other site 568703003021 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 568703003022 tRNA binding surface [nucleotide binding]; other site 568703003023 anticodon binding site; other site 568703003024 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 568703003025 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 568703003026 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003027 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703003028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703003029 motif II; other site 568703003030 hypothetical protein; Reviewed; Region: PRK00024 568703003031 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 568703003032 MPN+ (JAMM) motif; other site 568703003033 Zinc-binding site [ion binding]; other site 568703003034 rod shape-determining protein MreB; Provisional; Region: PRK13927 568703003035 Cell division protein FtsA; Region: FtsA; cl11496 568703003036 rod shape-determining protein MreC; Provisional; Region: PRK13922 568703003037 rod shape-determining protein MreC; Region: MreC; pfam04085 568703003038 rod shape-determining protein MreD; Region: MreD; cl01087 568703003039 septum formation inhibitor; Reviewed; Region: minC; PRK00513 568703003040 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 568703003041 septum site-determining protein MinD; Region: minD_bact; TIGR01968 568703003042 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 568703003043 Switch I; other site 568703003044 Switch II; other site 568703003045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703003046 dimer interface [polypeptide binding]; other site 568703003047 conserved gate region; other site 568703003048 putative PBP binding loops; other site 568703003049 ABC-ATPase subunit interface; other site 568703003050 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003052 Walker A/P-loop; other site 568703003053 ATP binding site [chemical binding]; other site 568703003054 Q-loop/lid; other site 568703003055 ABC transporter signature motif; other site 568703003056 Walker B; other site 568703003057 D-loop; other site 568703003058 H-loop/switch region; other site 568703003059 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 568703003060 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703003061 substrate binding pocket [chemical binding]; other site 568703003062 membrane-bound complex binding site; other site 568703003063 hinge residues; other site 568703003064 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568703003065 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703003066 putative active site [active] 568703003067 catalytic site [active] 568703003068 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703003069 putative active site [active] 568703003070 catalytic site [active] 568703003071 cell division protein MraZ; Reviewed; Region: PRK00326 568703003072 MraZ protein; Region: MraZ; pfam02381 568703003073 MraZ protein; Region: MraZ; pfam02381 568703003074 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 568703003075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703003076 Septum formation initiator; Region: DivIC; cl11433 568703003077 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703003078 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703003079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703003080 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 568703003081 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 568703003082 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 568703003083 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 568703003084 Mg++ binding site [ion binding]; other site 568703003085 putative catalytic motif [active] 568703003086 putative substrate binding site [chemical binding]; other site 568703003087 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 568703003088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703003090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703003091 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 568703003092 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 568703003093 active site 568703003094 homodimer interface [polypeptide binding]; other site 568703003095 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 568703003096 Cell division protein FtsQ; Region: FtsQ; pfam03799 568703003097 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 568703003098 Cell division protein FtsA; Region: FtsA; cl11496 568703003099 Cell division protein FtsA; Region: FtsA; cl11496 568703003100 cell division protein FtsZ; Validated; Region: PRK09330 568703003101 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 568703003102 nucleotide binding site [chemical binding]; other site 568703003103 SulA interaction site; other site 568703003104 Protein of unknown function (DUF552); Region: DUF552; cl00775 568703003105 YGGT family; Region: YGGT; cl00508 568703003106 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 568703003107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 568703003108 DivIVA protein; Region: DivIVA; pfam05103 568703003109 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703003110 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 568703003111 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 568703003112 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703003113 active site 568703003114 HIGH motif; other site 568703003115 nucleotide binding site [chemical binding]; other site 568703003116 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 568703003117 active site 568703003118 KMSKS motif; other site 568703003119 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 568703003120 tRNA binding surface [nucleotide binding]; other site 568703003121 anticodon binding site; other site 568703003122 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703003123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 568703003124 DNA-binding site [nucleotide binding]; DNA binding site 568703003125 RNA-binding motif; other site 568703003126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703003129 putative substrate translocation pore; other site 568703003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003131 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 568703003132 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 568703003133 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 568703003134 dimer interface [polypeptide binding]; other site 568703003135 ADP-ribose binding site [chemical binding]; other site 568703003136 active site 568703003137 nudix motif; other site 568703003138 metal binding site [ion binding]; metal-binding site 568703003139 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 568703003140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703003141 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 568703003142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703003143 catalytic residue [active] 568703003144 Domain of unknown function (DUF1831); Region: DUF1831; pfam08866 568703003145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003146 Walker A/P-loop; other site 568703003147 ATP binding site [chemical binding]; other site 568703003148 Q-loop/lid; other site 568703003149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003150 ABC transporter signature motif; other site 568703003151 Walker B; other site 568703003152 D-loop; other site 568703003153 H-loop/switch region; other site 568703003154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003155 Walker A/P-loop; other site 568703003156 ATP binding site [chemical binding]; other site 568703003157 Q-loop/lid; other site 568703003158 ABC transporter signature motif; other site 568703003159 Walker B; other site 568703003160 D-loop; other site 568703003161 H-loop/switch region; other site 568703003162 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 568703003163 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 568703003164 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703003165 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703003166 catalytic core [active] 568703003167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 568703003168 binding surface 568703003169 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 568703003170 TPR motif; other site 568703003171 RecD/TraA family; Region: recD_rel; TIGR01448 568703003172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703003173 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 568703003174 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703003175 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 568703003176 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003177 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703003178 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003179 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 568703003180 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 568703003181 active site 568703003182 catalytic residues [active] 568703003183 metal binding site [ion binding]; metal-binding site 568703003184 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703003185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703003186 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 568703003187 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 568703003188 TPP-binding site [chemical binding]; other site 568703003189 tetramer interface [polypeptide binding]; other site 568703003190 heterodimer interface [polypeptide binding]; other site 568703003191 phosphorylation loop region [posttranslational modification] 568703003192 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 568703003193 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 568703003194 alpha subunit interface [polypeptide binding]; other site 568703003195 TPP binding site [chemical binding]; other site 568703003196 heterodimer interface [polypeptide binding]; other site 568703003197 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 568703003198 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 568703003199 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 568703003200 E3 interaction surface; other site 568703003201 lipoyl attachment site [posttranslational modification]; other site 568703003202 e3 binding domain; Region: E3_binding; pfam02817 568703003203 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 568703003204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003205 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 568703003206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703003208 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 568703003209 substrate binding site [chemical binding]; other site 568703003210 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 568703003211 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 568703003212 active site 568703003213 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 568703003214 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 568703003215 G1 box; other site 568703003216 putative GEF interaction site [polypeptide binding]; other site 568703003217 GTP/Mg2+ binding site [chemical binding]; other site 568703003218 Switch I region; other site 568703003219 G2 box; other site 568703003220 G3 box; other site 568703003221 Switch II region; other site 568703003222 G4 box; other site 568703003223 G5 box; other site 568703003224 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 568703003225 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 568703003226 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 568703003227 pyruvate carboxylase; Reviewed; Region: PRK12999 568703003228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703003229 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703003230 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 568703003231 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703003232 active site 568703003233 catalytic residues [active] 568703003234 metal binding site [ion binding]; metal-binding site 568703003235 homodimer binding site [polypeptide binding]; other site 568703003236 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 568703003237 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 568703003238 carboxyltransferase (CT) interaction site; other site 568703003239 biotinylation site [posttranslational modification]; other site 568703003240 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 568703003241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703003242 S-adenosylmethionine binding site [chemical binding]; other site 568703003243 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 568703003244 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 568703003245 active site 568703003246 (T/H)XGH motif; other site 568703003247 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 568703003248 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 568703003249 protein binding site [polypeptide binding]; other site 568703003250 SLBB domain; Region: SLBB; pfam10531 568703003251 comEA protein; Region: comE; TIGR01259 568703003252 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 568703003253 Competence protein; Region: Competence; cl00471 568703003254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703003255 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 568703003256 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 568703003257 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 568703003258 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 568703003259 16S/18S rRNA binding site [nucleotide binding]; other site 568703003260 S13e-L30e interaction site [polypeptide binding]; other site 568703003261 25S rRNA binding site [nucleotide binding]; other site 568703003262 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 568703003263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703003264 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 568703003265 elongation factor Tu; Reviewed; Region: PRK00049 568703003266 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 568703003267 G1 box; other site 568703003268 GEF interaction site [polypeptide binding]; other site 568703003269 GTP/Mg2+ binding site [chemical binding]; other site 568703003270 Switch I region; other site 568703003271 G2 box; other site 568703003272 G3 box; other site 568703003273 Switch II region; other site 568703003274 G4 box; other site 568703003275 G5 box; other site 568703003276 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 568703003277 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 568703003278 Antibiotic Binding Site [chemical binding]; other site 568703003279 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003280 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 568703003281 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 568703003282 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 568703003283 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703003284 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703003285 DNA binding residues [nucleotide binding] 568703003286 putative dimer interface [polypeptide binding]; other site 568703003287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703003288 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703003289 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 568703003290 Walker A/P-loop; other site 568703003291 ATP binding site [chemical binding]; other site 568703003292 Q-loop/lid; other site 568703003293 ABC transporter signature motif; other site 568703003294 Walker B; other site 568703003295 D-loop; other site 568703003296 H-loop/switch region; other site 568703003297 trigger factor; Provisional; Region: tig; PRK01490 568703003298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 568703003299 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 568703003300 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 568703003301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 568703003302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703003303 Walker A motif; other site 568703003304 ATP binding site [chemical binding]; other site 568703003305 Walker B motif; other site 568703003306 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703003307 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 568703003308 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 568703003309 G1 box; other site 568703003310 GTP/Mg2+ binding site [chemical binding]; other site 568703003311 Switch I region; other site 568703003312 G2 box; other site 568703003313 G3 box; other site 568703003314 Switch II region; other site 568703003315 G4 box; other site 568703003316 G5 box; other site 568703003317 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 568703003318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703003319 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703003320 substrate binding pocket [chemical binding]; other site 568703003321 membrane-bound complex binding site; other site 568703003322 hinge residues; other site 568703003323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703003325 dimer interface [polypeptide binding]; other site 568703003326 conserved gate region; other site 568703003327 putative PBP binding loops; other site 568703003328 ABC-ATPase subunit interface; other site 568703003329 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703003330 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 568703003331 Walker A/P-loop; other site 568703003332 ATP binding site [chemical binding]; other site 568703003333 Q-loop/lid; other site 568703003334 ABC transporter signature motif; other site 568703003335 Walker B; other site 568703003336 D-loop; other site 568703003337 H-loop/switch region; other site 568703003338 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 568703003339 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 568703003340 GIY-YIG motif/motif A; other site 568703003341 active site 568703003342 catalytic site [active] 568703003343 putative DNA binding site [nucleotide binding]; other site 568703003344 metal binding site [ion binding]; metal-binding site 568703003345 UvrB/uvrC motif; Region: UVR; pfam02151 568703003346 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 568703003347 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 568703003348 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703003349 active site 568703003350 phosphorylation site [posttranslational modification] 568703003351 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 568703003352 P-loop; other site 568703003353 active site 568703003354 phosphorylation site [posttranslational modification] 568703003355 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703003356 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703003357 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703003358 putative substrate binding site [chemical binding]; other site 568703003359 putative ATP binding site [chemical binding]; other site 568703003360 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703003361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703003362 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703003363 GTPase CgtA; Reviewed; Region: obgE; PRK12297 568703003364 GTP1/OBG; Region: GTP1_OBG; pfam01018 568703003365 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 568703003366 G1 box; other site 568703003367 GTP/Mg2+ binding site [chemical binding]; other site 568703003368 Switch I region; other site 568703003369 G2 box; other site 568703003370 G3 box; other site 568703003371 Switch II region; other site 568703003372 G4 box; other site 568703003373 G5 box; other site 568703003374 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 568703003375 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 568703003376 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703003377 catalytic triad [active] 568703003378 catalytic triad [active] 568703003379 oxyanion hole [active] 568703003380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703003381 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 568703003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003383 NAD(P) binding site [chemical binding]; other site 568703003384 active site 568703003385 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 568703003386 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 568703003387 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003388 Clp amino terminal domain; Region: Clp_N; pfam02861 568703003389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703003390 Walker A motif; other site 568703003391 ATP binding site [chemical binding]; other site 568703003392 Walker B motif; other site 568703003393 arginine finger; other site 568703003394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703003395 Walker A motif; other site 568703003396 ATP binding site [chemical binding]; other site 568703003397 Walker B motif; other site 568703003398 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703003399 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 568703003400 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 568703003401 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 568703003402 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 568703003403 active site 568703003404 metal binding site [ion binding]; metal-binding site 568703003405 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 568703003406 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 568703003407 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 568703003408 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 568703003409 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 568703003410 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 568703003411 generic binding surface I; other site 568703003412 generic binding surface II; other site 568703003413 6-phosphofructokinase; Provisional; Region: PRK03202 568703003414 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 568703003415 active site 568703003416 ADP/pyrophosphate binding site [chemical binding]; other site 568703003417 dimerization interface [polypeptide binding]; other site 568703003418 allosteric effector site; other site 568703003419 fructose-1,6-bisphosphate binding site; other site 568703003420 pyruvate kinase; Provisional; Region: PRK06354 568703003421 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 568703003422 domain interfaces; other site 568703003423 active site 568703003424 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 568703003425 Protein of unknown function (DUF441); Region: DUF441; cl01041 568703003426 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 568703003427 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 568703003428 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 568703003429 Int/Topo IB signature motif; other site 568703003430 active site 568703003431 ScpA/B protein; Region: ScpA_ScpB; cl00598 568703003432 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 568703003433 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 568703003434 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003435 RNA binding surface [nucleotide binding]; other site 568703003436 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 568703003437 active site 568703003438 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 568703003439 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703003440 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 568703003441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 568703003442 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703003443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703003444 ATP binding site [chemical binding]; other site 568703003445 putative Mg++ binding site [ion binding]; other site 568703003446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703003447 nucleotide binding region [chemical binding]; other site 568703003448 ATP-binding site [chemical binding]; other site 568703003449 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 568703003450 putative peptidoglycan binding site; other site 568703003451 cytidylate kinase; Provisional; Region: cmk; PRK00023 568703003452 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 568703003453 CMP-binding site; other site 568703003454 The sites determining sugar specificity; other site 568703003455 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 568703003456 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 568703003457 RNA binding site [nucleotide binding]; other site 568703003458 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 568703003459 RNA binding site [nucleotide binding]; other site 568703003460 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 568703003461 RNA binding site [nucleotide binding]; other site 568703003462 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 568703003463 RNA binding site [nucleotide binding]; other site 568703003464 GTP-binding protein Der; Reviewed; Region: PRK00093 568703003465 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 568703003466 G1 box; other site 568703003467 GTP/Mg2+ binding site [chemical binding]; other site 568703003468 Switch I region; other site 568703003469 G2 box; other site 568703003470 Switch II region; other site 568703003471 G3 box; other site 568703003472 G4 box; other site 568703003473 G5 box; other site 568703003474 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 568703003475 G1 box; other site 568703003476 GTP/Mg2+ binding site [chemical binding]; other site 568703003477 Switch I region; other site 568703003478 G2 box; other site 568703003479 G3 box; other site 568703003480 Switch II region; other site 568703003481 G4 box; other site 568703003482 G5 box; other site 568703003483 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 568703003484 IHF dimer interface [polypeptide binding]; other site 568703003485 IHF - DNA interface [nucleotide binding]; other site 568703003486 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 568703003487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 568703003488 TPR motif; other site 568703003489 binding surface 568703003490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 568703003491 binding surface 568703003492 TPR motif; other site 568703003493 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703003494 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003495 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003496 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 568703003497 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 568703003498 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 568703003499 active site 568703003500 NTP binding site [chemical binding]; other site 568703003501 metal binding triad [ion binding]; metal-binding site 568703003502 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 568703003503 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703003504 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703003505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003506 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703003507 ABC transporter; Region: ABC_tran_2; pfam12848 568703003508 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703003509 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 568703003510 dimerization interface [polypeptide binding]; other site 568703003511 active site 568703003512 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 568703003513 folate binding site [chemical binding]; other site 568703003514 NADP+ binding site [chemical binding]; other site 568703003515 Haemolysin-III related; Region: HlyIII; cl03831 568703003516 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 568703003517 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 568703003518 active site 568703003519 catalytic triad [active] 568703003520 oxyanion hole [active] 568703003521 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 568703003522 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 568703003523 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 568703003524 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 568703003525 C-terminal peptidase (prc); Region: prc; TIGR00225 568703003526 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 568703003527 protein binding site [polypeptide binding]; other site 568703003528 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 568703003529 Catalytic dyad [active] 568703003530 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 568703003531 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 568703003532 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 568703003533 GTP/Mg2+ binding site [chemical binding]; other site 568703003534 G4 box; other site 568703003535 G5 box; other site 568703003536 G1 box; other site 568703003537 Switch I region; other site 568703003538 G2 box; other site 568703003539 G3 box; other site 568703003540 Switch II region; other site 568703003541 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 568703003542 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703003543 active site 568703003544 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 568703003545 DNA topoisomerase I; Validated; Region: PRK05582 568703003546 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 568703003547 active site 568703003548 interdomain interaction site; other site 568703003549 putative metal-binding site [ion binding]; other site 568703003550 nucleotide binding site [chemical binding]; other site 568703003551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 568703003552 domain I; other site 568703003553 DNA binding groove [nucleotide binding] 568703003554 phosphate binding site [ion binding]; other site 568703003555 domain II; other site 568703003556 domain III; other site 568703003557 nucleotide binding site [chemical binding]; other site 568703003558 catalytic site [active] 568703003559 domain IV; other site 568703003560 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 568703003561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 568703003562 DNA topoisomerase I; Validated; Region: PRK05582 568703003563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003564 Glucose inhibited division protein A; Region: GIDA; pfam01134 568703003565 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 568703003566 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 568703003567 Int/Topo IB signature motif; other site 568703003568 active site 568703003569 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 568703003570 active site 568703003571 HslU subunit interaction site [polypeptide binding]; other site 568703003572 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 568703003573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703003574 Walker A motif; other site 568703003575 ATP binding site [chemical binding]; other site 568703003576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703003578 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703003579 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 568703003580 active site 568703003581 catalytic residues [active] 568703003582 Domain of unknown function (DUF205); Region: DUF205; cl00410 568703003583 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 568703003584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568703003585 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 568703003586 anchoring element; other site 568703003587 dimer interface [polypeptide binding]; other site 568703003588 ATP binding site [chemical binding]; other site 568703003589 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 568703003590 active site 568703003591 putative metal-binding site [ion binding]; other site 568703003592 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 568703003593 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 568703003594 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 568703003595 CAP-like domain; other site 568703003596 Active site [active] 568703003597 primary dimer interface [polypeptide binding]; other site 568703003598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 568703003599 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 568703003600 Pyruvate formate lyase 1; Region: PFL1; cd01678 568703003601 coenzyme A binding site [chemical binding]; other site 568703003602 active site 568703003603 catalytic residues [active] 568703003604 glycine loop; other site 568703003605 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 568703003606 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 568703003607 FeS/SAM binding site; other site 568703003608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703003610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003611 dimerization interface [polypeptide binding]; other site 568703003612 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 568703003613 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703003614 DHHA2 domain; Region: DHHA2; pfam02833 568703003615 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 568703003616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 568703003617 DNA binding site [nucleotide binding] 568703003618 Int/Topo IB signature motif; other site 568703003619 active site 568703003620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703003621 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703003622 Walker A/P-loop; other site 568703003623 ATP binding site [chemical binding]; other site 568703003624 Q-loop/lid; other site 568703003625 ABC transporter signature motif; other site 568703003626 Walker B; other site 568703003627 D-loop; other site 568703003628 H-loop/switch region; other site 568703003629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703003630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703003631 ATP binding site [chemical binding]; other site 568703003632 Mg2+ binding site [ion binding]; other site 568703003633 G-X-G motif; other site 568703003634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703003635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703003636 active site 568703003637 phosphorylation site [posttranslational modification] 568703003638 intermolecular recognition site; other site 568703003639 dimerization interface [polypeptide binding]; other site 568703003640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703003641 DNA binding site [nucleotide binding] 568703003642 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703003643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703003644 putative substrate translocation pore; other site 568703003645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703003646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703003647 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 568703003648 dimer interface [polypeptide binding]; other site 568703003649 FMN binding site [chemical binding]; other site 568703003650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 568703003651 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 568703003652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003654 homodimer interface [polypeptide binding]; other site 568703003655 catalytic residue [active] 568703003656 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 568703003657 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 568703003658 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 568703003659 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 568703003660 substrate binding site [chemical binding]; other site 568703003661 glutamase interaction surface [polypeptide binding]; other site 568703003662 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 568703003663 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 568703003664 catalytic residues [active] 568703003665 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 568703003666 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 568703003667 putative active site [active] 568703003668 oxyanion strand; other site 568703003669 catalytic triad [active] 568703003670 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 568703003671 4-fold oligomerization interface [polypeptide binding]; other site 568703003672 putative active site pocket [active] 568703003673 metal binding residues [ion binding]; metal-binding site 568703003674 3-fold/trimer interface [polypeptide binding]; other site 568703003675 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 568703003676 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 568703003677 NAD binding site [chemical binding]; other site 568703003678 dimerization interface [polypeptide binding]; other site 568703003679 product binding site; other site 568703003680 substrate binding site [chemical binding]; other site 568703003681 zinc binding site [ion binding]; other site 568703003682 catalytic residues [active] 568703003683 ATP phosphoribosyltransferase; Region: HisG; cl15266 568703003684 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 568703003685 dimer interface [polypeptide binding]; other site 568703003686 motif 1; other site 568703003687 active site 568703003688 motif 2; other site 568703003689 histidine-tRNA ligase; Region: PLN02530 568703003690 motif 3; other site 568703003691 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 568703003692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003694 homodimer interface [polypeptide binding]; other site 568703003695 catalytic residue [active] 568703003696 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 568703003697 dimer interface [polypeptide binding]; other site 568703003698 ADP-ribose binding site [chemical binding]; other site 568703003699 active site 568703003700 nudix motif; other site 568703003701 metal binding site [ion binding]; metal-binding site 568703003702 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 568703003703 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 568703003704 Domain of unknown function (DUF814); Region: DUF814; pfam05670 568703003705 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703003706 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703003707 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 568703003708 active site 568703003709 dimer interface [polypeptide binding]; other site 568703003710 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 568703003711 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 568703003712 heterodimer interface [polypeptide binding]; other site 568703003713 active site 568703003714 FMN binding site [chemical binding]; other site 568703003715 homodimer interface [polypeptide binding]; other site 568703003716 substrate binding site [chemical binding]; other site 568703003717 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 568703003718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703003719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703003720 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 568703003721 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703003722 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703003723 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 568703003724 IMP binding site; other site 568703003725 dimer interface [polypeptide binding]; other site 568703003726 interdomain contacts; other site 568703003727 partial ornithine binding site; other site 568703003728 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 568703003729 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 568703003730 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 568703003731 catalytic site [active] 568703003732 subunit interface [polypeptide binding]; other site 568703003733 dihydroorotase; Validated; Region: pyrC; PRK09357 568703003734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703003735 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 568703003736 active site 568703003737 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 568703003738 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 568703003739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003740 Sulfate transporter family; Region: Sulfate_transp; cl00967 568703003741 Permease family; Region: Xan_ur_permease; pfam00860 568703003742 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703003743 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 568703003744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 568703003745 RNA binding surface [nucleotide binding]; other site 568703003746 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 568703003747 active site 568703003748 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 568703003749 lipoprotein signal peptidase; Provisional; Region: PRK14787 568703003750 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 568703003751 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 568703003752 Potassium binding sites [ion binding]; other site 568703003753 Cesium cation binding sites [ion binding]; other site 568703003754 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 568703003755 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703003756 active site 568703003757 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 568703003758 dimer interface [polypeptide binding]; other site 568703003759 FMN binding site [chemical binding]; other site 568703003760 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 568703003761 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 568703003762 putative active site [active] 568703003763 catalytic site [active] 568703003764 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 568703003765 putative active site [active] 568703003766 catalytic site [active] 568703003767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703003768 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 568703003769 catalytic residues [active] 568703003770 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 568703003771 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 568703003772 Class I ribonucleotide reductase; Region: RNR_I; cd01679 568703003773 active site 568703003774 dimer interface [polypeptide binding]; other site 568703003775 catalytic residues [active] 568703003776 effector binding site; other site 568703003777 R2 peptide binding site; other site 568703003778 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 568703003779 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 568703003780 dimer interface [polypeptide binding]; other site 568703003781 putative radical transfer pathway; other site 568703003782 diiron center [ion binding]; other site 568703003783 tyrosyl radical; other site 568703003784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703003785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703003786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703003787 dimerization interface [polypeptide binding]; other site 568703003788 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 568703003789 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 568703003790 active site 568703003791 Zn binding site [ion binding]; other site 568703003792 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 568703003793 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568703003794 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 568703003795 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 568703003796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703003797 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 568703003798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703003799 cell division protein GpsB; Provisional; Region: PRK14127 568703003800 DivIVA domain; Region: DivI1A_domain; TIGR03544 568703003801 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 568703003802 Recombination protein U; Region: RecU; cl01314 568703003803 Transglycosylase; Region: Transgly; cl07896 568703003804 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703003805 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703003806 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 568703003807 catalytic motif [active] 568703003808 Zn binding site [ion binding]; other site 568703003809 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 568703003810 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 568703003811 minor groove reading motif; other site 568703003812 helix-hairpin-helix signature motif; other site 568703003813 substrate binding pocket [chemical binding]; other site 568703003814 active site 568703003815 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 568703003816 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 568703003817 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 568703003818 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 568703003819 putative dimer interface [polypeptide binding]; other site 568703003820 putative anticodon binding site; other site 568703003821 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 568703003822 homodimer interface [polypeptide binding]; other site 568703003823 motif 1; other site 568703003824 motif 2; other site 568703003825 active site 568703003826 motif 3; other site 568703003827 hypothetical protein; Validated; Region: PRK07682 568703003828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703003829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703003830 homodimer interface [polypeptide binding]; other site 568703003831 catalytic residue [active] 568703003832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 568703003833 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 568703003834 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703003835 active site 568703003836 substrate binding site [chemical binding]; other site 568703003837 catalytic site [active] 568703003838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003839 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 568703003840 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703003841 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703003842 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 568703003843 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 568703003844 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 568703003845 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 568703003846 mevalonate kinase; Region: mevalon_kin; TIGR00549 568703003847 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 568703003848 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703003849 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 568703003850 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 568703003851 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 568703003852 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 568703003853 homotetramer interface [polypeptide binding]; other site 568703003854 FMN binding site [chemical binding]; other site 568703003855 homodimer contacts [polypeptide binding]; other site 568703003856 putative active site [active] 568703003857 putative substrate binding site [chemical binding]; other site 568703003858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703003859 S-adenosylmethionine binding site [chemical binding]; other site 568703003860 Uncharacterized conserved protein [Function unknown]; Region: COG3270 568703003861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703003862 Domain of unknown function DUF59; Region: DUF59; cl00941 568703003863 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 568703003864 active site 1 [active] 568703003865 dimer interface [polypeptide binding]; other site 568703003866 hexamer interface [polypeptide binding]; other site 568703003867 active site 2 [active] 568703003868 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703003869 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703003870 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 568703003871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703003872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703003873 Walker A/P-loop; other site 568703003874 ATP binding site [chemical binding]; other site 568703003875 Q-loop/lid; other site 568703003876 ABC transporter signature motif; other site 568703003877 Walker B; other site 568703003878 D-loop; other site 568703003879 H-loop/switch region; other site 568703003880 Uncharacterized conserved protein [Function unknown]; Region: COG0327 568703003881 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 568703003882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703003883 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 568703003884 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 568703003885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 568703003886 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 568703003887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 568703003888 DNA binding residues [nucleotide binding] 568703003889 DNA primase; Validated; Region: dnaG; PRK05667 568703003890 CHC2 zinc finger; Region: zf-CHC2; cl02597 568703003891 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 568703003892 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 568703003893 active site 568703003894 metal binding site [ion binding]; metal-binding site 568703003895 interdomain interaction site; other site 568703003896 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 568703003897 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 568703003898 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 568703003899 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 568703003900 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 568703003901 dimer interface [polypeptide binding]; other site 568703003902 motif 1; other site 568703003903 active site 568703003904 motif 2; other site 568703003905 motif 3; other site 568703003906 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703003907 Phage integrase family; Region: Phage_integrase; pfam00589 568703003908 Int/Topo IB signature motif; other site 568703003909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703003910 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 568703003911 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703003912 active site 568703003913 Bacterial SH3 domain; Region: SH3_3; cl02551 568703003914 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 568703003915 putative peptidoglycan binding site; other site 568703003916 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 568703003917 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 568703003918 Phage tail protein; Region: Sipho_tail; cl11462 568703003919 Phage tail protein; Region: Sipho_tail; cl11462 568703003920 Phage-related tail protein [Function unknown]; Region: COG5283 568703003921 HemX; Region: HemX; cl14667 568703003922 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 568703003923 N-acetyl-D-glucosamine binding site [chemical binding]; other site 568703003924 catalytic residue [active] 568703003925 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 568703003926 Phage major tail protein; Region: Phage_tail; pfam04630 568703003927 Protein of unknown function (DUF806); Region: DUF806; pfam05657 568703003928 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 568703003929 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 568703003930 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 568703003931 Phage capsid family; Region: Phage_capsid; pfam05065 568703003932 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568703003933 Phage portal protein; Region: Phage_portal; pfam04860 568703003934 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 568703003935 Phage Terminase; Region: Terminase_1; pfam03354 568703003936 Phage terminase, small subunit; Region: Terminase_4; cl01525 568703003937 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 568703003938 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 568703003939 catalytic residues [active] 568703003940 catalytic nucleophile [active] 568703003941 Presynaptic Site I dimer interface [polypeptide binding]; other site 568703003942 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 568703003943 Synaptic Flat tetramer interface [polypeptide binding]; other site 568703003944 Synaptic Site I dimer interface [polypeptide binding]; other site 568703003945 DNA binding site [nucleotide binding] 568703003946 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 568703003947 DXD motif; other site 568703003948 Transposase domain (DUF772); Region: DUF772; cl12084 568703003949 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 568703003950 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 568703003951 dimer interface [polypeptide binding]; other site 568703003952 ssDNA binding site [nucleotide binding]; other site 568703003953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703003954 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703003955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703003956 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 568703003957 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703003958 Walker A/P-loop; other site 568703003959 ATP binding site [chemical binding]; other site 568703003960 Q-loop/lid; other site 568703003961 ABC transporter signature motif; other site 568703003962 Walker B; other site 568703003963 D-loop; other site 568703003964 H-loop/switch region; other site 568703003965 Recombination protein O N terminal; Region: RecO_N; pfam11967 568703003966 DNA repair protein RecO; Region: reco; TIGR00613 568703003967 Recombination protein O C terminal; Region: RecO_C; pfam02565 568703003968 GTPase Era; Reviewed; Region: era; PRK00089 568703003969 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 568703003970 G1 box; other site 568703003971 GTP/Mg2+ binding site [chemical binding]; other site 568703003972 Switch I region; other site 568703003973 G2 box; other site 568703003974 Switch II region; other site 568703003975 G3 box; other site 568703003976 G4 box; other site 568703003977 G5 box; other site 568703003978 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 568703003979 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 568703003980 active site 568703003981 catalytic motif [active] 568703003982 Zn binding site [ion binding]; other site 568703003983 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 568703003984 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 568703003985 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 568703003986 PhoH-like protein; Region: PhoH; cl12134 568703003987 GatB domain; Region: GatB_Yqey; cl11497 568703003988 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 568703003989 Domain of unknown function (DUF299); Region: DUF299; cl00780 568703003990 endonuclease IV; Provisional; Region: PRK01060 568703003991 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 568703003992 AP (apurinic/apyrimidinic) site pocket; other site 568703003993 DNA interaction; other site 568703003994 Metal-binding active site; metal-binding site 568703003995 Uncharacterized conserved protein [Function unknown]; Region: COG1284 568703003996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703003997 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 568703003998 SelR domain; Region: SelR; cl00369 568703003999 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 568703004000 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 568703004001 dimer interface [polypeptide binding]; other site 568703004002 anticodon binding site; other site 568703004003 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 568703004004 homodimer interface [polypeptide binding]; other site 568703004005 motif 1; other site 568703004006 active site 568703004007 motif 2; other site 568703004008 GAD domain; Region: GAD; pfam02938 568703004009 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 568703004010 motif 3; other site 568703004011 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 568703004012 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 568703004013 dimer interface [polypeptide binding]; other site 568703004014 motif 1; other site 568703004015 active site 568703004016 motif 2; other site 568703004017 motif 3; other site 568703004018 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 568703004019 anticodon binding site; other site 568703004020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703004021 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 568703004022 Walker A/P-loop; other site 568703004023 ATP binding site [chemical binding]; other site 568703004024 Q-loop/lid; other site 568703004025 ABC transporter signature motif; other site 568703004026 Walker B; other site 568703004027 D-loop; other site 568703004028 H-loop/switch region; other site 568703004029 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 568703004030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 568703004031 Bacterial SH3 domain; Region: SH3_3; cl02551 568703004032 Bacterial SH3 domain; Region: SH3_3; cl02551 568703004033 Bacterial SH3 domain; Region: SH3_3; cl02551 568703004034 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 568703004035 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 568703004036 active site 568703004037 metal binding site [ion binding]; metal-binding site 568703004038 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 568703004039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703004040 motif II; other site 568703004041 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 568703004042 putative active site [active] 568703004043 dimerization interface [polypeptide binding]; other site 568703004044 putative tRNAtyr binding site [nucleotide binding]; other site 568703004045 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 568703004046 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703004047 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 568703004048 synthetase active site [active] 568703004049 NTP binding site [chemical binding]; other site 568703004050 metal binding site [ion binding]; metal-binding site 568703004051 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 568703004052 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 568703004053 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 568703004054 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 568703004055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703004056 S-adenosylmethionine binding site [chemical binding]; other site 568703004057 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 568703004058 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 568703004059 active site 568703004060 DNA binding site [nucleotide binding] 568703004061 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703004062 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703004063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703004064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703004065 Transposase domain (DUF772); Region: DUF772; cl12084 568703004066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 568703004067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703004068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703004069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703004070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703004071 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703004072 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703004073 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004074 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703004075 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703004076 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703004077 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703004078 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004079 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004080 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004081 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004082 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703004083 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703004084 N-formylglutamate amidohydrolase; Region: FGase; cl01522 568703004085 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 568703004086 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 568703004087 putative deacylase active site [active] 568703004088 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703004089 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 568703004090 DHH family; Region: DHH; pfam01368 568703004091 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 568703004092 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703004093 GTP-binding protein LepA; Provisional; Region: PRK05433 568703004094 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 568703004095 G1 box; other site 568703004096 putative GEF interaction site [polypeptide binding]; other site 568703004097 GTP/Mg2+ binding site [chemical binding]; other site 568703004098 Switch I region; other site 568703004099 G2 box; other site 568703004100 G3 box; other site 568703004101 Switch II region; other site 568703004102 G4 box; other site 568703004103 G5 box; other site 568703004104 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 568703004105 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 568703004106 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 568703004107 chaperone protein DnaJ; Provisional; Region: PRK14276 568703004108 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 568703004109 HSP70 interaction site [polypeptide binding]; other site 568703004110 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 568703004111 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 568703004112 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 568703004113 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 568703004114 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 568703004115 dimer interface [polypeptide binding]; other site 568703004116 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 568703004117 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 568703004118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004119 HrcA protein C terminal domain; Region: HrcA; pfam01628 568703004120 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 568703004121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 568703004122 HemN C-terminal region; Region: HemN_C; pfam06969 568703004123 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 568703004124 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 568703004125 active site 568703004126 Riboflavin kinase; Region: Flavokinase; cl03312 568703004127 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 568703004128 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 568703004129 RNA binding site [nucleotide binding]; other site 568703004130 active site 568703004131 Integral membrane protein TerC family; Region: TerC; cl10468 568703004132 Ribosome-binding factor A; Region: RBFA; cl00542 568703004133 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004134 translation initiation factor IF-2; Region: IF-2; TIGR00487 568703004135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 568703004136 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 568703004137 G1 box; other site 568703004138 putative GEF interaction site [polypeptide binding]; other site 568703004139 GTP/Mg2+ binding site [chemical binding]; other site 568703004140 Switch I region; other site 568703004141 G2 box; other site 568703004142 G3 box; other site 568703004143 Switch II region; other site 568703004144 G4 box; other site 568703004145 G5 box; other site 568703004146 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 568703004147 Translation-initiation factor 2; Region: IF-2; pfam11987 568703004148 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 568703004149 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 568703004150 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 568703004151 putative RNA binding cleft [nucleotide binding]; other site 568703004152 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 568703004153 NusA N-terminal domain; Region: NusA_N; pfam08529 568703004154 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 568703004155 RNA binding site [nucleotide binding]; other site 568703004156 homodimer interface [polypeptide binding]; other site 568703004157 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 568703004158 G-X-X-G motif; other site 568703004159 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 568703004160 ribosome maturation protein RimP; Reviewed; Region: PRK00092 568703004161 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 568703004162 Sm1 motif; other site 568703004163 predicted subunit interaction site [polypeptide binding]; other site 568703004164 RNA binding pocket [nucleotide binding]; other site 568703004165 Sm2 motif; other site 568703004166 DNA polymerase III PolC; Validated; Region: polC; PRK00448 568703004167 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 568703004168 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 568703004169 generic binding surface II; other site 568703004170 generic binding surface I; other site 568703004171 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 568703004172 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 568703004173 active site 568703004174 substrate binding site [chemical binding]; other site 568703004175 catalytic site [active] 568703004176 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 568703004177 prolyl-tRNA synthetase; Provisional; Region: PRK09194 568703004178 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 568703004179 dimer interface [polypeptide binding]; other site 568703004180 motif 1; other site 568703004181 active site 568703004182 motif 2; other site 568703004183 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 568703004184 putative deacylase active site [active] 568703004185 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 568703004186 active site 568703004187 motif 3; other site 568703004188 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 568703004189 anticodon binding site; other site 568703004190 RIP metalloprotease RseP; Region: TIGR00054 568703004191 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 568703004192 active site 568703004193 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004194 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 568703004195 protein binding site [polypeptide binding]; other site 568703004196 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 568703004197 putative substrate binding region [chemical binding]; other site 568703004198 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 568703004199 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 568703004200 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 568703004201 catalytic residue [active] 568703004202 putative FPP diphosphate binding site; other site 568703004203 putative FPP binding hydrophobic cleft; other site 568703004204 dimer interface [polypeptide binding]; other site 568703004205 putative IPP diphosphate binding site; other site 568703004206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703004207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703004208 putative transposase OrfB; Reviewed; Region: PHA02517 568703004209 Integrase core domain; Region: rve; cl01316 568703004210 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 568703004211 hinge region; other site 568703004212 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 568703004213 putative nucleotide binding site [chemical binding]; other site 568703004214 uridine monophosphate binding site [chemical binding]; other site 568703004215 homohexameric interface [polypeptide binding]; other site 568703004216 elongation factor Ts; Provisional; Region: tsf; PRK09377 568703004217 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 568703004218 Elongation factor TS; Region: EF_TS; pfam00889 568703004219 Elongation factor TS; Region: EF_TS; pfam00889 568703004220 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 568703004221 rRNA interaction site [nucleotide binding]; other site 568703004222 S8 interaction site; other site 568703004223 putative laminin-1 binding site; other site 568703004224 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 568703004225 GIY-YIG motif/motif A; other site 568703004226 putative active site [active] 568703004227 putative metal binding site [ion binding]; other site 568703004228 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 568703004229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703004230 S-adenosylmethionine binding site [chemical binding]; other site 568703004231 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 568703004232 putative acyl-acceptor binding pocket; other site 568703004233 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 568703004234 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703004235 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 568703004236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004237 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703004238 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 568703004239 Walker A/P-loop; other site 568703004240 ATP binding site [chemical binding]; other site 568703004241 Q-loop/lid; other site 568703004242 ABC transporter signature motif; other site 568703004243 Walker B; other site 568703004244 D-loop; other site 568703004245 H-loop/switch region; other site 568703004246 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703004247 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 568703004248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703004249 Walker A/P-loop; other site 568703004250 ATP binding site [chemical binding]; other site 568703004251 Q-loop/lid; other site 568703004252 ABC transporter signature motif; other site 568703004253 Walker B; other site 568703004254 D-loop; other site 568703004255 H-loop/switch region; other site 568703004256 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 568703004257 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 568703004258 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 568703004259 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 568703004260 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 568703004261 RimM N-terminal domain; Region: RimM; pfam01782 568703004262 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 568703004263 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 568703004264 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 568703004265 signal recognition particle protein; Provisional; Region: PRK10867 568703004266 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 568703004267 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004268 P loop; other site 568703004269 GTP binding site [chemical binding]; other site 568703004270 Signal peptide binding domain; Region: SRP_SPB; pfam02978 568703004271 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 568703004272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703004273 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 568703004274 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 568703004275 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 568703004276 P loop; other site 568703004277 GTP binding site [chemical binding]; other site 568703004278 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 568703004279 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 568703004280 Walker A/P-loop; other site 568703004281 ATP binding site [chemical binding]; other site 568703004282 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 568703004283 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 568703004284 ABC transporter signature motif; other site 568703004285 Walker B; other site 568703004286 D-loop; other site 568703004287 H-loop/switch region; other site 568703004288 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 568703004289 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 568703004290 dimerization interface [polypeptide binding]; other site 568703004291 active site 568703004292 metal binding site [ion binding]; metal-binding site 568703004293 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 568703004294 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 568703004295 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 568703004296 peptide binding site [polypeptide binding]; other site 568703004297 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703004298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 568703004299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703004300 dimer interface [polypeptide binding]; other site 568703004301 conserved gate region; other site 568703004302 putative PBP binding loops; other site 568703004303 ABC-ATPase subunit interface; other site 568703004304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703004306 dimer interface [polypeptide binding]; other site 568703004307 conserved gate region; other site 568703004308 putative PBP binding loops; other site 568703004309 ABC-ATPase subunit interface; other site 568703004310 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703004311 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703004312 Walker A/P-loop; other site 568703004313 ATP binding site [chemical binding]; other site 568703004314 Q-loop/lid; other site 568703004315 ABC transporter signature motif; other site 568703004316 Walker B; other site 568703004317 D-loop; other site 568703004318 H-loop/switch region; other site 568703004319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703004320 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703004321 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703004322 Walker A/P-loop; other site 568703004323 ATP binding site [chemical binding]; other site 568703004324 Q-loop/lid; other site 568703004325 ABC transporter signature motif; other site 568703004326 Walker B; other site 568703004327 D-loop; other site 568703004328 H-loop/switch region; other site 568703004329 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703004330 Phosphopantetheine attachment site; Region: PP-binding; cl09936 568703004331 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 568703004332 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 568703004333 Y-family of DNA polymerases; Region: PolY; cl12025 568703004334 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 568703004335 generic binding surface II; other site 568703004336 ssDNA binding site; other site 568703004337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004338 ATP binding site [chemical binding]; other site 568703004339 putative Mg++ binding site [ion binding]; other site 568703004340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004341 nucleotide binding region [chemical binding]; other site 568703004342 ATP-binding site [chemical binding]; other site 568703004343 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 568703004344 DAK2 domain; Region: Dak2; cl03685 568703004345 Protein of unknown function (DUF322); Region: DUF322; cl00574 568703004346 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 568703004347 Thiamine pyrophosphokinase; Region: TPK; cd07995 568703004348 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 568703004349 active site 568703004350 dimerization interface [polypeptide binding]; other site 568703004351 thiamine binding site [chemical binding]; other site 568703004352 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 568703004353 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 568703004354 substrate binding site [chemical binding]; other site 568703004355 hexamer interface [polypeptide binding]; other site 568703004356 metal binding site [ion binding]; metal-binding site 568703004357 GTPase RsgA; Reviewed; Region: PRK00098 568703004358 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 568703004359 GTPase/OB domain interface [polypeptide binding]; other site 568703004360 GTPase/Zn-binding domain interface [polypeptide binding]; other site 568703004361 GTP/Mg2+ binding site [chemical binding]; other site 568703004362 G4 box; other site 568703004363 G5 box; other site 568703004364 G1 box; other site 568703004365 Switch I region; other site 568703004366 G2 box; other site 568703004367 G3 box; other site 568703004368 Switch II region; other site 568703004369 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 568703004370 Catalytic domain of Protein Kinases; Region: PKc; cd00180 568703004371 active site 568703004372 ATP binding site [chemical binding]; other site 568703004373 substrate binding site [chemical binding]; other site 568703004374 activation loop (A-loop); other site 568703004375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 568703004376 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 568703004377 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 568703004378 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 568703004379 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 568703004380 Active site [active] 568703004381 16S rRNA methyltransferase B; Provisional; Region: PRK14902 568703004382 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 568703004383 putative RNA binding site [nucleotide binding]; other site 568703004384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703004385 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 568703004386 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 568703004387 putative active site [active] 568703004388 substrate binding site [chemical binding]; other site 568703004389 putative cosubstrate binding site; other site 568703004390 catalytic site [active] 568703004391 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 568703004392 substrate binding site [chemical binding]; other site 568703004393 primosome assembly protein PriA; Validated; Region: PRK05580 568703004394 primosome assembly protein PriA; Validated; Region: PRK05580 568703004395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703004396 ATP binding site [chemical binding]; other site 568703004397 putative Mg++ binding site [ion binding]; other site 568703004398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703004399 nucleotide binding region [chemical binding]; other site 568703004400 ATP-binding site [chemical binding]; other site 568703004401 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 568703004402 Flavoprotein; Region: Flavoprotein; cl08021 568703004403 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 568703004404 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 568703004405 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 568703004406 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 568703004407 catalytic site [active] 568703004408 G-X2-G-X-G-K; other site 568703004409 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 568703004410 nucleophile elbow; other site 568703004411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 568703004412 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 568703004413 Walker A/P-loop; other site 568703004414 ATP binding site [chemical binding]; other site 568703004415 Q-loop/lid; other site 568703004416 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 568703004417 ABC transporter signature motif; other site 568703004418 Walker B; other site 568703004419 D-loop; other site 568703004420 H-loop/switch region; other site 568703004421 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703004422 arginine repressor; Provisional; Region: PRK04280 568703004423 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703004424 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 568703004425 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 568703004426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703004427 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703004428 substrate binding pocket [chemical binding]; other site 568703004429 chain length determination region; other site 568703004430 substrate-Mg2+ binding site; other site 568703004431 catalytic residues [active] 568703004432 aspartate-rich region 1; other site 568703004433 active site lid residues [active] 568703004434 aspartate-rich region 2; other site 568703004435 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 568703004436 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 568703004437 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 568703004438 generic binding surface II; other site 568703004439 generic binding surface I; other site 568703004440 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 568703004441 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 568703004442 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 568703004443 homodimer interface [polypeptide binding]; other site 568703004444 NADP binding site [chemical binding]; other site 568703004445 substrate binding site [chemical binding]; other site 568703004446 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 568703004447 Protein of unknown function (DUF322); Region: DUF322; cl00574 568703004448 elongation factor P; Validated; Region: PRK00529 568703004449 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703004450 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 568703004451 RNA binding site [nucleotide binding]; other site 568703004452 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 568703004453 RNA binding site [nucleotide binding]; other site 568703004454 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 568703004455 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 568703004456 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 568703004457 active site 568703004458 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 568703004459 Protein of unknown function (DUF464); Region: DUF464; cl01080 568703004460 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 568703004461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703004462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703004463 Walker A/P-loop; other site 568703004464 ATP binding site [chemical binding]; other site 568703004465 Q-loop/lid; other site 568703004466 ABC transporter signature motif; other site 568703004467 Walker B; other site 568703004468 D-loop; other site 568703004469 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 568703004470 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 568703004471 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 568703004472 glutamine synthetase, type I; Region: GlnA; TIGR00653 568703004473 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 568703004474 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 568703004475 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 568703004476 DNA binding residues [nucleotide binding] 568703004477 putative dimer interface [polypeptide binding]; other site 568703004478 ornithine decarboxylase; Provisional; Region: PRK13578 568703004479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703004480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703004481 catalytic residue [active] 568703004482 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 568703004483 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 568703004484 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703004485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703004486 catalytic residue [active] 568703004487 IPP transferase; Region: IPPT; cl00403 568703004488 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 568703004489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 568703004490 active site residue [active] 568703004491 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 568703004492 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 568703004493 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 568703004494 Rhomboid family; Region: Rhomboid; cl11446 568703004495 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 568703004496 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 568703004497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703004498 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703004499 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 568703004500 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 568703004501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 568703004502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703004503 active site 568703004504 phosphorylation site [posttranslational modification] 568703004505 intermolecular recognition site; other site 568703004506 dimerization interface [polypeptide binding]; other site 568703004507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 568703004508 DNA binding residues [nucleotide binding] 568703004509 dimerization interface [polypeptide binding]; other site 568703004510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004511 Histidine kinase; Region: HisKA_3; pfam07730 568703004512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004513 ATP binding site [chemical binding]; other site 568703004514 Mg2+ binding site [ion binding]; other site 568703004515 G-X-G motif; other site 568703004516 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 568703004517 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 568703004518 domain; Region: GreA_GreB_N; pfam03449 568703004519 C-term; Region: GreA_GreB; pfam01272 568703004520 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 568703004521 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 568703004522 ATP-binding site [chemical binding]; other site 568703004523 Sugar specificity; other site 568703004524 Pyrimidine base specificity; other site 568703004525 YceG-like family; Region: YceG; pfam02618 568703004526 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 568703004527 dimerization interface [polypeptide binding]; other site 568703004528 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 568703004529 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703004530 putative tRNA-binding site [nucleotide binding]; other site 568703004531 B3/4 domain; Region: B3_4; cl11458 568703004532 tRNA synthetase B5 domain; Region: B5; cl08394 568703004533 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 568703004534 dimer interface [polypeptide binding]; other site 568703004535 motif 1; other site 568703004536 motif 3; other site 568703004537 motif 2; other site 568703004538 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 568703004539 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 568703004540 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 568703004541 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 568703004542 dimer interface [polypeptide binding]; other site 568703004543 motif 1; other site 568703004544 active site 568703004545 motif 2; other site 568703004546 motif 3; other site 568703004547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703004549 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 568703004550 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 568703004551 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 568703004552 Acylphosphatase; Region: Acylphosphatase; cl00551 568703004553 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703004554 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 568703004555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703004556 dimer interface [polypeptide binding]; other site 568703004557 phosphorylation site [posttranslational modification] 568703004558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004559 ATP binding site [chemical binding]; other site 568703004560 Mg2+ binding site [ion binding]; other site 568703004561 G-X-G motif; other site 568703004562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703004564 active site 568703004565 phosphorylation site [posttranslational modification] 568703004566 intermolecular recognition site; other site 568703004567 dimerization interface [polypeptide binding]; other site 568703004568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703004569 DNA binding site [nucleotide binding] 568703004570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703004571 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 568703004572 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 568703004573 Peptidase family M23; Region: Peptidase_M23; pfam01551 568703004574 Probable transposase; Region: OrfB_IS605; pfam01385 568703004575 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 568703004576 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 568703004577 hypothetical protein; Provisional; Region: PRK13670 568703004578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703004579 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 568703004580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703004581 S-adenosylmethionine binding site [chemical binding]; other site 568703004582 Domain of unknown function DUF143; Region: DUF143; cl00519 568703004583 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 568703004584 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703004585 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 568703004586 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 568703004587 active site 568703004588 (T/H)XGH motif; other site 568703004589 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 568703004590 GTPase YqeH; Provisional; Region: PRK13796 568703004591 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 568703004592 GTP/Mg2+ binding site [chemical binding]; other site 568703004593 G4 box; other site 568703004594 G5 box; other site 568703004595 G1 box; other site 568703004596 Switch I region; other site 568703004597 G2 box; other site 568703004598 G3 box; other site 568703004599 Switch II region; other site 568703004600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703004601 active site 568703004602 motif I; other site 568703004603 motif II; other site 568703004604 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004605 Zn binding site [ion binding]; other site 568703004606 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004607 Zn binding site [ion binding]; other site 568703004608 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 568703004609 Zn binding site [ion binding]; other site 568703004610 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 568703004611 Zn binding site [ion binding]; other site 568703004612 Predicted esterase [General function prediction only]; Region: COG0400 568703004613 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703004614 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 568703004615 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 568703004616 putative NAD(P) binding site [chemical binding]; other site 568703004617 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 568703004618 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 568703004619 23S rRNA binding site [nucleotide binding]; other site 568703004620 L21 binding site [polypeptide binding]; other site 568703004621 L13 binding site [polypeptide binding]; other site 568703004622 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 568703004623 translation initiation factor IF-3; Region: infC; TIGR00168 568703004624 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 568703004625 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 568703004626 Predicted transcriptional regulator [Transcription]; Region: COG1959 568703004627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004629 Transposase domain (DUF772); Region: DUF772; cl12084 568703004630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703004631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703004632 putative substrate translocation pore; other site 568703004633 NAD-dependent deacetylase; Provisional; Region: PRK14138 568703004634 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 568703004635 SseB protein; Region: SseB; cl06279 568703004636 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 568703004637 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 568703004638 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 568703004639 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 568703004640 active site 568703004641 dimer interface [polypeptide binding]; other site 568703004642 motif 1; other site 568703004643 motif 2; other site 568703004644 motif 3; other site 568703004645 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 568703004646 anticodon binding site; other site 568703004647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703004648 non-specific DNA binding site [nucleotide binding]; other site 568703004649 salt bridge; other site 568703004650 sequence-specific DNA binding site [nucleotide binding]; other site 568703004651 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 568703004652 primosomal protein DnaI; Reviewed; Region: PRK08939 568703004653 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 568703004654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703004655 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 568703004656 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 568703004657 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 568703004658 ATP cone domain; Region: ATP-cone; pfam03477 568703004659 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 568703004660 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 568703004661 CoA-binding site [chemical binding]; other site 568703004662 ATP-binding [chemical binding]; other site 568703004663 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 568703004664 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 568703004665 DNA binding site [nucleotide binding] 568703004666 catalytic residue [active] 568703004667 H2TH interface [polypeptide binding]; other site 568703004668 putative catalytic residues [active] 568703004669 turnover-facilitating residue; other site 568703004670 intercalation triad [nucleotide binding]; other site 568703004671 8OG recognition residue [nucleotide binding]; other site 568703004672 putative reading head residues; other site 568703004673 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 568703004674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 568703004675 DNA polymerase I; Provisional; Region: PRK05755 568703004676 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 568703004677 active site 568703004678 metal binding site 1 [ion binding]; metal-binding site 568703004679 putative 5' ssDNA interaction site; other site 568703004680 metal binding site 3; metal-binding site 568703004681 metal binding site 2 [ion binding]; metal-binding site 568703004682 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 568703004683 putative DNA binding site [nucleotide binding]; other site 568703004684 putative metal binding site [ion binding]; other site 568703004685 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 568703004686 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 568703004687 active site 568703004688 DNA binding site [nucleotide binding] 568703004689 catalytic site [active] 568703004690 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 568703004691 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703004692 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703004693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004694 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 568703004695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703004696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703004697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703004698 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 568703004699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703004700 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 568703004701 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 568703004702 putative tRNA-binding site [nucleotide binding]; other site 568703004703 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 568703004704 catalytic residues [active] 568703004705 Predicted small secreted protein [Function unknown]; Region: COG5584 568703004706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703004707 S-adenosylmethionine binding site [chemical binding]; other site 568703004708 Phosphotransferase enzyme family; Region: APH; pfam01636 568703004709 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 568703004710 active site 568703004711 substrate binding site [chemical binding]; other site 568703004712 ATP binding site [chemical binding]; other site 568703004713 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 568703004714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 568703004715 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703004716 Walker A/P-loop; other site 568703004717 ATP binding site [chemical binding]; other site 568703004718 Q-loop/lid; other site 568703004719 ABC transporter signature motif; other site 568703004720 Walker B; other site 568703004721 D-loop; other site 568703004722 H-loop/switch region; other site 568703004723 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 568703004724 HIT family signature motif; other site 568703004725 catalytic residue [active] 568703004726 YtxH-like protein; Region: YtxH; cl02079 568703004727 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703004728 PPIC-type PPIASE domain; Region: Rotamase; cl08278 568703004729 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 568703004730 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 568703004731 generic binding surface I; other site 568703004732 generic binding surface II; other site 568703004733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703004734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703004735 Zn2+ binding site [ion binding]; other site 568703004736 Mg2+ binding site [ion binding]; other site 568703004737 Protein of unknown function (DUF964); Region: DUF964; cl01483 568703004738 Transglycosylase; Region: Transgly; cl07896 568703004739 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 568703004740 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 568703004741 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703004742 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 568703004743 active site 568703004744 Arginine repressor [Transcription]; Region: ArgR; COG1438 568703004745 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 568703004746 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 568703004747 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 568703004748 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 568703004749 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 568703004750 active site 568703004751 HIGH motif; other site 568703004752 KMSK motif region; other site 568703004753 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 568703004754 tRNA binding surface [nucleotide binding]; other site 568703004755 anticodon binding site; other site 568703004756 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 568703004757 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 568703004758 active site 568703004759 FMN binding site [chemical binding]; other site 568703004760 substrate binding site [chemical binding]; other site 568703004761 catalytic residues [active] 568703004762 homodimer interface [polypeptide binding]; other site 568703004763 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 568703004764 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 568703004765 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 568703004766 putative active site [active] 568703004767 catalytic site [active] 568703004768 putative metal binding site [ion binding]; other site 568703004769 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 568703004770 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 568703004771 putative catalytic residues [active] 568703004772 thiol/disulfide switch; other site 568703004773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703004774 FtsX-like permease family; Region: FtsX; pfam02687 568703004775 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703004776 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703004777 Walker A/P-loop; other site 568703004778 ATP binding site [chemical binding]; other site 568703004779 Q-loop/lid; other site 568703004780 ABC transporter signature motif; other site 568703004781 Walker B; other site 568703004782 D-loop; other site 568703004783 H-loop/switch region; other site 568703004784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703004785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703004786 active site 568703004787 phosphorylation site [posttranslational modification] 568703004788 intermolecular recognition site; other site 568703004789 dimerization interface [polypeptide binding]; other site 568703004790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703004791 DNA binding site [nucleotide binding] 568703004792 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 568703004793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 568703004794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 568703004795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703004796 ATP binding site [chemical binding]; other site 568703004797 Mg2+ binding site [ion binding]; other site 568703004798 G-X-G motif; other site 568703004799 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 568703004800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 568703004801 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 568703004802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703004803 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 568703004804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004805 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 568703004806 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 568703004807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703004808 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 568703004809 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 568703004810 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 568703004811 purine monophosphate binding site [chemical binding]; other site 568703004812 dimer interface [polypeptide binding]; other site 568703004813 putative catalytic residues [active] 568703004814 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568703004815 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 568703004816 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 568703004817 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 568703004818 active site 568703004819 substrate binding site [chemical binding]; other site 568703004820 cosubstrate binding site; other site 568703004821 catalytic site [active] 568703004822 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 568703004823 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 568703004824 dimerization interface [polypeptide binding]; other site 568703004825 putative ATP binding site [chemical binding]; other site 568703004826 amidophosphoribosyltransferase; Provisional; Region: PRK07272 568703004827 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 568703004828 active site 568703004829 tetramer interface [polypeptide binding]; other site 568703004830 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703004831 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 568703004832 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 568703004833 dimerization interface [polypeptide binding]; other site 568703004834 ATP binding site [chemical binding]; other site 568703004835 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 568703004836 dimerization interface [polypeptide binding]; other site 568703004837 ATP binding site [chemical binding]; other site 568703004838 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 568703004839 putative active site [active] 568703004840 catalytic triad [active] 568703004841 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 568703004842 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 568703004843 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 568703004844 ATP binding site [chemical binding]; other site 568703004845 active site 568703004846 substrate binding site [chemical binding]; other site 568703004847 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 568703004848 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703004849 AIR carboxylase; Region: AIRC; cl00310 568703004850 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 568703004851 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703004852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703004853 putative substrate translocation pore; other site 568703004854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703004855 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 568703004856 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 568703004857 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 568703004858 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 568703004859 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 568703004860 dimerization domain swap beta strand [polypeptide binding]; other site 568703004861 regulatory protein interface [polypeptide binding]; other site 568703004862 active site 568703004863 regulatory phosphorylation site [posttranslational modification]; other site 568703004864 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 568703004865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703004866 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703004867 Walker A motif; other site 568703004868 ATP binding site [chemical binding]; other site 568703004869 Walker B motif; other site 568703004870 arginine finger; other site 568703004871 UvrB/uvrC motif; Region: UVR; pfam02151 568703004872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703004873 Walker A motif; other site 568703004874 ATP binding site [chemical binding]; other site 568703004875 Walker B motif; other site 568703004876 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703004877 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703004878 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 568703004879 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 568703004880 G1 box; other site 568703004881 putative GEF interaction site [polypeptide binding]; other site 568703004882 GTP/Mg2+ binding site [chemical binding]; other site 568703004883 Switch I region; other site 568703004884 G2 box; other site 568703004885 G3 box; other site 568703004886 Switch II region; other site 568703004887 G4 box; other site 568703004888 G5 box; other site 568703004889 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 568703004890 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 568703004891 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703004892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703004893 Transporter associated domain; Region: CorC_HlyC; cl08393 568703004894 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 568703004895 Domain of unknown function DUF20; Region: UPF0118; cl00465 568703004896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703004897 Coenzyme A binding pocket [chemical binding]; other site 568703004898 Protein of unknown function (DUF402); Region: DUF402; cl00979 568703004899 RecX family; Region: RecX; cl00936 568703004900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004901 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703004902 TRAM domain; Region: TRAM; cl01282 568703004903 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 568703004904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703004905 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 568703004906 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703004907 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703004908 PYR/PP interface [polypeptide binding]; other site 568703004909 tetramer interface [polypeptide binding]; other site 568703004910 dimer interface [polypeptide binding]; other site 568703004911 TPP binding site [chemical binding]; other site 568703004912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703004913 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 568703004914 TPP-binding site [chemical binding]; other site 568703004915 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 568703004916 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 568703004917 dimer interface [polypeptide binding]; other site 568703004918 active site 568703004919 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 568703004920 homodimer interface [polypeptide binding]; other site 568703004921 NAD binding site [chemical binding]; other site 568703004922 catalytic residues [active] 568703004923 substrate binding pocket [chemical binding]; other site 568703004924 flexible flap; other site 568703004925 putative acyltransferase; Provisional; Region: PRK05790 568703004926 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 568703004927 dimer interface [polypeptide binding]; other site 568703004928 active site 568703004929 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 568703004930 Restriction endonuclease; Region: Mrr_cat; cl00747 568703004931 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 568703004932 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 568703004933 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 568703004934 metal binding site [ion binding]; metal-binding site 568703004935 dimer interface [polypeptide binding]; other site 568703004936 Predicted membrane protein [Function unknown]; Region: COG4684 568703004937 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 568703004938 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703004939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703004940 Coenzyme A binding pocket [chemical binding]; other site 568703004941 hypothetical protein; Provisional; Region: PRK04351 568703004942 SprT homologues; Region: SprT; cl01182 568703004943 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 568703004944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703004945 Walker A/P-loop; other site 568703004946 ATP binding site [chemical binding]; other site 568703004947 Q-loop/lid; other site 568703004948 ABC transporter signature motif; other site 568703004949 Walker B; other site 568703004950 D-loop; other site 568703004951 H-loop/switch region; other site 568703004952 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 568703004953 TM-ABC transporter signature motif; other site 568703004954 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 568703004955 zinc binding site [ion binding]; other site 568703004956 putative ligand binding site [chemical binding]; other site 568703004957 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703004958 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703004959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703004960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703004961 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703004962 Beta-lactamase; Region: Beta-lactamase; cl01009 568703004963 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 568703004964 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 568703004965 homodimer interface [polypeptide binding]; other site 568703004966 NAD binding pocket [chemical binding]; other site 568703004967 ATP binding pocket [chemical binding]; other site 568703004968 Mg binding site [ion binding]; other site 568703004969 active-site loop [active] 568703004970 Beta-lactamase; Region: Beta-lactamase; cl01009 568703004971 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703004972 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 568703004973 active site 568703004974 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703004975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703004976 DNA-binding site [nucleotide binding]; DNA binding site 568703004977 UTRA domain; Region: UTRA; cl01230 568703004978 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 568703004979 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 568703004980 active site 568703004981 dimer interface [polypeptide binding]; other site 568703004982 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 568703004983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703004984 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 568703004985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703004986 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703004987 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703004988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703004989 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703004990 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 568703004991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703004992 putative substrate translocation pore; other site 568703004993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 568703004994 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703004995 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703004996 Walker A/P-loop; other site 568703004997 ATP binding site [chemical binding]; other site 568703004998 Q-loop/lid; other site 568703004999 ABC transporter signature motif; other site 568703005000 Walker B; other site 568703005001 D-loop; other site 568703005002 H-loop/switch region; other site 568703005003 FtsX-like permease family; Region: FtsX; pfam02687 568703005004 putative transporter; Provisional; Region: PRK11462 568703005005 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568703005006 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703005007 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 568703005008 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 568703005009 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 568703005010 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 568703005011 G1 box; other site 568703005012 GTP/Mg2+ binding site [chemical binding]; other site 568703005013 Switch I region; other site 568703005014 G2 box; other site 568703005015 G3 box; other site 568703005016 Switch II region; other site 568703005017 G4 box; other site 568703005018 G5 box; other site 568703005019 Nucleoside recognition; Region: Gate; cl00486 568703005020 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 568703005021 Nucleoside recognition; Region: Gate; cl00486 568703005022 FeoA domain; Region: FeoA; cl00838 568703005023 FeoA domain; Region: FeoA; cl00838 568703005024 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005025 catalytic triad [active] 568703005026 catalytic triad [active] 568703005027 oxyanion hole [active] 568703005028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005029 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 568703005030 NAD binding site [chemical binding]; other site 568703005031 substrate binding site [chemical binding]; other site 568703005032 putative active site [active] 568703005033 seryl-tRNA synthetase; Provisional; Region: PRK05431 568703005034 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 568703005035 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 568703005036 dimer interface [polypeptide binding]; other site 568703005037 active site 568703005038 motif 1; other site 568703005039 motif 2; other site 568703005040 motif 3; other site 568703005041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005043 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703005044 Amino acid permease; Region: AA_permease; pfam00324 568703005045 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 568703005046 acetolactate synthase; Reviewed; Region: PRK08617 568703005047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 568703005048 PYR/PP interface [polypeptide binding]; other site 568703005049 dimer interface [polypeptide binding]; other site 568703005050 TPP binding site [chemical binding]; other site 568703005051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005052 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 568703005053 TPP-binding site [chemical binding]; other site 568703005054 dimer interface [polypeptide binding]; other site 568703005055 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703005056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703005057 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 568703005058 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 568703005059 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 568703005060 Fic family protein [Function unknown]; Region: COG3177 568703005061 Fic/DOC family; Region: Fic; cl00960 568703005062 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 568703005063 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 568703005064 active site 568703005065 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 568703005066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703005067 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 568703005068 Transcriptional regulators [Transcription]; Region: GntR; COG1802 568703005069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005070 DNA-binding site [nucleotide binding]; DNA binding site 568703005071 FCD domain; Region: FCD; cl11656 568703005072 oxaloacetate decarboxylase; Provisional; Region: PRK12331 568703005073 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 568703005074 active site 568703005075 catalytic residues [active] 568703005076 metal binding site [ion binding]; metal-binding site 568703005077 homodimer binding site [polypeptide binding]; other site 568703005078 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 568703005079 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 568703005080 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 568703005081 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703005082 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 568703005083 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 568703005084 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 568703005085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 568703005086 active site 568703005087 nucleotide binding site [chemical binding]; other site 568703005088 HIGH motif; other site 568703005089 KMSKS motif; other site 568703005090 subunit; Region: OAD_beta; cl00816 568703005091 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 568703005092 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 568703005093 carboxyltransferase (CT) interaction site; other site 568703005094 biotinylation site [posttranslational modification]; other site 568703005095 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703005096 Citrate transporter; Region: CitMHS; pfam03600 568703005097 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 568703005098 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 568703005099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005100 Coenzyme A binding pocket [chemical binding]; other site 568703005101 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703005102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005104 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 568703005105 dimer interface [polypeptide binding]; other site 568703005106 FMN binding site [chemical binding]; other site 568703005107 NADPH bind site [chemical binding]; other site 568703005108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703005109 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703005110 Walker A/P-loop; other site 568703005111 ATP binding site [chemical binding]; other site 568703005112 Q-loop/lid; other site 568703005113 ABC transporter signature motif; other site 568703005114 Walker B; other site 568703005115 D-loop; other site 568703005116 H-loop/switch region; other site 568703005117 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 568703005118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703005119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703005120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005122 putative substrate translocation pore; other site 568703005123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005124 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 568703005125 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 568703005126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005127 non-specific DNA binding site [nucleotide binding]; other site 568703005128 salt bridge; other site 568703005129 sequence-specific DNA binding site [nucleotide binding]; other site 568703005130 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703005131 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703005132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005133 DNA-binding site [nucleotide binding]; DNA binding site 568703005134 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703005135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005136 Walker A/P-loop; other site 568703005137 ATP binding site [chemical binding]; other site 568703005138 ABC transporter signature motif; other site 568703005139 Walker B; other site 568703005140 D-loop; other site 568703005141 H-loop/switch region; other site 568703005142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005143 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703005144 Walker A/P-loop; other site 568703005145 ATP binding site [chemical binding]; other site 568703005146 Q-loop/lid; other site 568703005147 ABC transporter signature motif; other site 568703005148 Walker B; other site 568703005149 D-loop; other site 568703005150 H-loop/switch region; other site 568703005151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005152 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005153 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703005154 Walker A/P-loop; other site 568703005155 ATP binding site [chemical binding]; other site 568703005156 Q-loop/lid; other site 568703005157 ABC transporter signature motif; other site 568703005158 Walker B; other site 568703005159 D-loop; other site 568703005160 H-loop/switch region; other site 568703005161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005162 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 568703005163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005164 dimer interface [polypeptide binding]; other site 568703005165 conserved gate region; other site 568703005166 putative PBP binding loops; other site 568703005167 ABC-ATPase subunit interface; other site 568703005168 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005170 dimer interface [polypeptide binding]; other site 568703005171 conserved gate region; other site 568703005172 putative PBP binding loops; other site 568703005173 ABC-ATPase subunit interface; other site 568703005174 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005175 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005176 peptide binding site [polypeptide binding]; other site 568703005177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005178 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005179 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005180 Walker A/P-loop; other site 568703005181 ATP binding site [chemical binding]; other site 568703005182 Q-loop/lid; other site 568703005183 ABC transporter signature motif; other site 568703005184 Walker B; other site 568703005185 D-loop; other site 568703005186 H-loop/switch region; other site 568703005187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703005188 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005189 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 568703005190 Walker A/P-loop; other site 568703005191 ATP binding site [chemical binding]; other site 568703005192 Q-loop/lid; other site 568703005193 ABC transporter signature motif; other site 568703005194 Walker B; other site 568703005195 D-loop; other site 568703005196 H-loop/switch region; other site 568703005197 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 568703005198 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 568703005199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703005200 ATP binding site [chemical binding]; other site 568703005201 putative Mg++ binding site [ion binding]; other site 568703005202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005203 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 568703005204 substrate binding site [chemical binding]; other site 568703005205 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 568703005206 active site 568703005207 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 568703005208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005209 non-specific DNA binding site [nucleotide binding]; other site 568703005210 salt bridge; other site 568703005211 sequence-specific DNA binding site [nucleotide binding]; other site 568703005212 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 568703005213 putative active site [active] 568703005214 putative NTP binding site [chemical binding]; other site 568703005215 putative nucleic acid binding site [nucleotide binding]; other site 568703005216 Transposase domain (DUF772); Region: DUF772; cl12084 568703005217 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703005218 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 568703005219 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 568703005220 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 568703005221 Transposase domain (DUF772); Region: DUF772; cl12084 568703005222 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 568703005223 GMP synthase; Reviewed; Region: guaA; PRK00074 568703005224 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 568703005225 AMP/PPi binding site [chemical binding]; other site 568703005226 candidate oxyanion hole; other site 568703005227 catalytic triad [active] 568703005228 potential glutamine specificity residues [chemical binding]; other site 568703005229 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 568703005230 ATP Binding subdomain [chemical binding]; other site 568703005231 Dimerization subdomain; other site 568703005232 pantothenate kinase; Provisional; Region: PRK05439 568703005233 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 568703005234 ATP-binding site [chemical binding]; other site 568703005235 CoA-binding site [chemical binding]; other site 568703005236 Mg2+-binding site [ion binding]; other site 568703005237 Peptidase family C69; Region: Peptidase_C69; cl01920 568703005238 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 568703005239 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703005240 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703005241 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 568703005242 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 568703005243 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 568703005244 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703005245 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703005246 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 568703005247 Ferrochelatase; Region: Ferrochelatase; pfam00762 568703005248 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 568703005249 C-terminal domain interface [polypeptide binding]; other site 568703005250 active site 568703005251 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 568703005252 active site 568703005253 N-terminal domain interface [polypeptide binding]; other site 568703005254 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703005255 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005256 catalytic core [active] 568703005257 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005258 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 568703005259 intersubunit interface [polypeptide binding]; other site 568703005260 active site 568703005261 Zn2+ binding site [ion binding]; other site 568703005262 FtsX-like permease family; Region: FtsX; pfam02687 568703005263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703005264 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703005265 Walker A/P-loop; other site 568703005266 ATP binding site [chemical binding]; other site 568703005267 Q-loop/lid; other site 568703005268 ABC transporter signature motif; other site 568703005269 Walker B; other site 568703005270 D-loop; other site 568703005271 H-loop/switch region; other site 568703005272 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703005273 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 568703005274 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 568703005275 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 568703005276 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 568703005277 G1 box; other site 568703005278 GTP/Mg2+ binding site [chemical binding]; other site 568703005279 Switch I region; other site 568703005280 G2 box; other site 568703005281 G3 box; other site 568703005282 Switch II region; other site 568703005283 G4 box; other site 568703005284 G5 box; other site 568703005285 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 568703005286 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005287 active site 568703005288 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 568703005289 homodimer interface [polypeptide binding]; other site 568703005290 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 568703005291 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 568703005292 NADP binding site [chemical binding]; other site 568703005293 active site 568703005294 putative substrate binding site [chemical binding]; other site 568703005295 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005296 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005297 NAD binding site [chemical binding]; other site 568703005298 substrate binding site [chemical binding]; other site 568703005299 homodimer interface [polypeptide binding]; other site 568703005300 active site 568703005301 Cupin domain; Region: Cupin_2; cl09118 568703005302 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 568703005303 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 568703005304 substrate binding site [chemical binding]; other site 568703005305 tetramer interface [polypeptide binding]; other site 568703005306 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and...; Region: GH25_AtlA-like; cd06522 568703005307 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 568703005308 active site 568703005309 Transposase domain (DUF772); Region: DUF772; cl12084 568703005310 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 568703005311 Bacterial sugar transferase; Region: Bac_transf; cl00939 568703005312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005313 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 568703005314 NAD(P) binding site [chemical binding]; other site 568703005315 active site 568703005316 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005318 dimer interface [polypeptide binding]; other site 568703005319 conserved gate region; other site 568703005320 putative PBP binding loops; other site 568703005321 ABC-ATPase subunit interface; other site 568703005322 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703005323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005324 dimer interface [polypeptide binding]; other site 568703005325 conserved gate region; other site 568703005326 putative PBP binding loops; other site 568703005327 ABC-ATPase subunit interface; other site 568703005328 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 568703005329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703005330 substrate binding pocket [chemical binding]; other site 568703005331 membrane-bound complex binding site; other site 568703005332 hinge residues; other site 568703005333 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703005334 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 568703005335 Walker A/P-loop; other site 568703005336 ATP binding site [chemical binding]; other site 568703005337 Q-loop/lid; other site 568703005338 ABC transporter signature motif; other site 568703005339 Walker B; other site 568703005340 D-loop; other site 568703005341 H-loop/switch region; other site 568703005342 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 568703005343 metal binding site 2 [ion binding]; metal-binding site 568703005344 putative DNA binding helix; other site 568703005345 metal binding site 1 [ion binding]; metal-binding site 568703005346 dimer interface [polypeptide binding]; other site 568703005347 structural Zn2+ binding site [ion binding]; other site 568703005348 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 568703005349 catalytic site [active] 568703005350 G-X2-G-X-G-K; other site 568703005351 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 568703005352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005353 Coenzyme A binding pocket [chemical binding]; other site 568703005354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 568703005355 NlpC/P60 family; Region: NLPC_P60; cl11438 568703005356 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 568703005357 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 568703005358 active site 568703005359 HIGH motif; other site 568703005360 dimer interface [polypeptide binding]; other site 568703005361 KMSKS motif; other site 568703005362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 568703005363 Cation efflux family; Region: Cation_efflux; cl00316 568703005364 Cation efflux family; Region: Cation_efflux; cl00316 568703005365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703005366 dimerization interface [polypeptide binding]; other site 568703005367 putative DNA binding site [nucleotide binding]; other site 568703005368 putative Zn2+ binding site [ion binding]; other site 568703005369 ApbE family; Region: ApbE; cl00643 568703005370 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703005371 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 568703005372 homodimer interface [polypeptide binding]; other site 568703005373 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 568703005374 active site pocket [active] 568703005375 glycogen synthase; Provisional; Region: glgA; PRK00654 568703005376 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 568703005377 ADP-binding pocket [chemical binding]; other site 568703005378 homodimer interface [polypeptide binding]; other site 568703005379 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 568703005380 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005381 active site 568703005382 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 568703005383 dimer interface [polypeptide binding]; other site 568703005384 N-terminal domain interface [polypeptide binding]; other site 568703005385 sulfate 1 binding site; other site 568703005386 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 568703005387 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 568703005388 ligand binding site [chemical binding]; other site 568703005389 oligomer interface [polypeptide binding]; other site 568703005390 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 568703005391 dimer interface [polypeptide binding]; other site 568703005392 N-terminal domain interface [polypeptide binding]; other site 568703005393 sulfate 1 binding site; other site 568703005394 glycogen branching enzyme; Provisional; Region: PRK12313 568703005395 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 568703005396 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703005397 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 568703005398 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 568703005399 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 568703005400 homodimer interface [polypeptide binding]; other site 568703005401 substrate-cofactor binding pocket; other site 568703005402 catalytic residue [active] 568703005403 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 568703005404 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 568703005405 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 568703005406 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 568703005407 Transposase domain (DUF772); Region: DUF772; cl12084 568703005408 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 568703005409 putative catalytic residues [active] 568703005410 thiol/disulfide switch; other site 568703005411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703005412 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 568703005413 Walker A motif; other site 568703005414 ATP binding site [chemical binding]; other site 568703005415 Walker B motif; other site 568703005416 arginine finger; other site 568703005417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703005418 Walker A motif; other site 568703005419 ATP binding site [chemical binding]; other site 568703005420 Walker B motif; other site 568703005421 arginine finger; other site 568703005422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703005423 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 568703005424 PHP domain; Region: PHP; pfam02811 568703005425 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703005426 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 568703005427 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 568703005428 NAD binding site [chemical binding]; other site 568703005429 substrate binding site [chemical binding]; other site 568703005430 homodimer interface [polypeptide binding]; other site 568703005431 active site 568703005432 Cupin domain; Region: Cupin_2; cl09118 568703005433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005434 Transposase domain (DUF772); Region: DUF772; cl12084 568703005435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 568703005436 active site 568703005437 Bacterial sugar transferase; Region: Bac_transf; cl00939 568703005438 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 568703005439 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703005440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703005441 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 568703005442 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 568703005443 Probable Catalytic site [active] 568703005444 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 568703005445 putative ADP-binding pocket [chemical binding]; other site 568703005446 MatE; Region: MatE; cl10513 568703005447 MatE; Region: MatE; cl10513 568703005448 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 568703005449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005450 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 568703005451 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 568703005452 Chain length determinant protein; Region: Wzz; cl01623 568703005453 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 568703005454 catalytic triad [active] 568703005455 catalytic triad [active] 568703005456 oxyanion hole [active] 568703005457 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 568703005458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703005459 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 568703005460 QueT transporter; Region: QueT; cl01932 568703005461 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568703005462 classical (c) SDRs; Region: SDR_c; cd05233 568703005463 NAD(P) binding site [chemical binding]; other site 568703005464 active site 568703005465 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 568703005466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005467 non-specific DNA binding site [nucleotide binding]; other site 568703005468 salt bridge; other site 568703005469 sequence-specific DNA binding site [nucleotide binding]; other site 568703005470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005471 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703005472 catalytic core [active] 568703005473 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 568703005474 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703005475 Walker A/P-loop; other site 568703005476 ATP binding site [chemical binding]; other site 568703005477 Q-loop/lid; other site 568703005478 ABC transporter signature motif; other site 568703005479 Walker B; other site 568703005480 D-loop; other site 568703005481 H-loop/switch region; other site 568703005482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005483 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 568703005484 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 568703005485 Walker A/P-loop; other site 568703005486 ATP binding site [chemical binding]; other site 568703005487 Q-loop/lid; other site 568703005488 ABC transporter signature motif; other site 568703005489 Walker B; other site 568703005490 D-loop; other site 568703005491 H-loop/switch region; other site 568703005492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 568703005493 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 568703005494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005495 dimer interface [polypeptide binding]; other site 568703005496 conserved gate region; other site 568703005497 putative PBP binding loops; other site 568703005498 ABC-ATPase subunit interface; other site 568703005499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 568703005500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005501 dimer interface [polypeptide binding]; other site 568703005502 conserved gate region; other site 568703005503 putative PBP binding loops; other site 568703005504 ABC-ATPase subunit interface; other site 568703005505 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703005506 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703005507 peptide binding site [polypeptide binding]; other site 568703005508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703005510 putative substrate translocation pore; other site 568703005511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005512 elongation factor P; Validated; Region: PRK00529 568703005513 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 568703005514 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 568703005515 RNA binding site [nucleotide binding]; other site 568703005516 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 568703005517 RNA binding site [nucleotide binding]; other site 568703005518 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 568703005519 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 568703005520 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 568703005521 C subunit; Region: glycerol3P_GlpC; TIGR03379 568703005522 Cysteine-rich domain; Region: CCG; pfam02754 568703005523 Cysteine-rich domain; Region: CCG; pfam02754 568703005524 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703005525 active site 568703005526 methionine cluster; other site 568703005527 phosphorylation site [posttranslational modification] 568703005528 metal binding site [ion binding]; metal-binding site 568703005529 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703005530 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703005531 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 568703005532 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005533 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 568703005534 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 568703005535 catalytic site [active] 568703005536 Protein of unknown function (DUF328); Region: DUF328; cl01143 568703005537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005538 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 568703005539 RecD/TraA family; Region: recD_rel; TIGR01448 568703005540 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 568703005541 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 568703005542 substrate binding site [chemical binding]; other site 568703005543 ATP binding site [chemical binding]; other site 568703005544 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 568703005545 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703005546 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703005547 active site 568703005548 metal binding site [ion binding]; metal-binding site 568703005549 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 568703005550 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 568703005551 Uncharacterized conserved protein [Function unknown]; Region: COG3535 568703005552 Protein of unknown function (DUF917); Region: DUF917; pfam06032 568703005553 Sodium:solute symporter family; Region: SSF; cl00456 568703005554 Protein of unknown function DUF262; Region: DUF262; cl14890 568703005555 Protein of unknown function DUF262; Region: DUF262; cl14890 568703005556 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 568703005557 putative ATP-dependent protease; Region: PHA01747; cl11979 568703005558 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 568703005559 TIGR02687 family protein; Region: TIGR02687 568703005560 PglZ domain; Region: PglZ; pfam08665 568703005561 Phage integrase family; Region: Phage_integrase; pfam00589 568703005562 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703005563 Int/Topo IB signature motif; other site 568703005564 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 568703005565 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 568703005566 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 568703005567 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 568703005568 Protein of unknown function (DUF998); Region: DUF998; cl01334 568703005569 Predicted membrane protein [Function unknown]; Region: COG1511 568703005570 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703005571 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005572 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 568703005573 HPr interaction site; other site 568703005574 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703005575 active site 568703005576 phosphorylation site [posttranslational modification] 568703005577 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703005578 active site turn [active] 568703005579 phosphorylation site [posttranslational modification] 568703005580 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005581 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703005582 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703005583 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703005584 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703005585 DNA binding site [nucleotide binding] 568703005586 domain linker motif; other site 568703005587 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 568703005588 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 568703005589 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 568703005590 substrate binding [chemical binding]; other site 568703005591 active site 568703005592 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 568703005593 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 568703005594 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 568703005595 NADP binding site [chemical binding]; other site 568703005596 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 568703005597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703005598 S-adenosylmethionine binding site [chemical binding]; other site 568703005599 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 568703005600 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 568703005601 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 568703005602 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 568703005603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 568703005604 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 568703005605 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 568703005606 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703005607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 568703005608 carboxyltransferase (CT) interaction site; other site 568703005609 biotinylation site [posttranslational modification]; other site 568703005610 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 568703005611 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 568703005612 dimer interface [polypeptide binding]; other site 568703005613 active site 568703005614 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 568703005615 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 568703005616 NAD(P) binding site [chemical binding]; other site 568703005617 homotetramer interface [polypeptide binding]; other site 568703005618 homodimer interface [polypeptide binding]; other site 568703005619 active site 568703005620 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 568703005621 Acyl transferase domain; Region: Acyl_transf_1; cl08282 568703005622 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 568703005623 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 568703005624 FMN binding site [chemical binding]; other site 568703005625 substrate binding site [chemical binding]; other site 568703005626 putative catalytic residue [active] 568703005627 Phosphopantetheine attachment site; Region: PP-binding; cl09936 568703005628 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 568703005629 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 568703005630 dimer interface [polypeptide binding]; other site 568703005631 active site 568703005632 CoA binding pocket [chemical binding]; other site 568703005633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005634 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 568703005635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703005636 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 568703005637 dimer interface [polypeptide binding]; other site 568703005638 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 568703005639 active site 568703005640 metal binding site [ion binding]; metal-binding site 568703005641 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 568703005642 active site residue [active] 568703005643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703005645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005646 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 568703005647 Predicted esterase [General function prediction only]; Region: COG0627 568703005648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703005649 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 568703005650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703005651 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703005652 nudix motif; other site 568703005653 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703005654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005655 catalytic core [active] 568703005656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703005657 Double zinc ribbon; Region: DZR; pfam12773 568703005658 Beta-lactamase; Region: Beta-lactamase; cl01009 568703005659 Domain of unknown function DUF20; Region: UPF0118; cl00465 568703005660 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 568703005661 active site 568703005662 catalytic site [active] 568703005663 GtrA-like protein; Region: GtrA; cl00971 568703005664 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 568703005665 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 568703005666 PYR/PP interface [polypeptide binding]; other site 568703005667 tetramer interface [polypeptide binding]; other site 568703005668 dimer interface [polypeptide binding]; other site 568703005669 TPP binding site [chemical binding]; other site 568703005670 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 568703005671 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 568703005672 TPP-binding site [chemical binding]; other site 568703005673 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703005674 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703005675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703005676 dimer interface [polypeptide binding]; other site 568703005677 conserved gate region; other site 568703005678 putative PBP binding loops; other site 568703005679 ABC-ATPase subunit interface; other site 568703005680 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 568703005681 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 568703005682 Walker A/P-loop; other site 568703005683 ATP binding site [chemical binding]; other site 568703005684 Q-loop/lid; other site 568703005685 ABC transporter signature motif; other site 568703005686 Walker B; other site 568703005687 D-loop; other site 568703005688 H-loop/switch region; other site 568703005689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703005690 Sugar fermentation stimulation protein; Region: SfsA; cl00647 568703005691 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703005692 Ligand Binding Site [chemical binding]; other site 568703005693 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 568703005694 homoserine kinase; Provisional; Region: PRK01212 568703005695 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 568703005696 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 568703005697 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 568703005698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 568703005699 catalytic residue [active] 568703005700 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 568703005701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005702 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 568703005703 aspartate kinase; Reviewed; Region: PRK09034 568703005704 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 568703005705 nucleotide binding site [chemical binding]; other site 568703005706 substrate binding site [chemical binding]; other site 568703005707 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703005708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703005709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 568703005710 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 568703005711 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005712 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703005713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703005714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703005715 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005716 D-lactate dehydrogenase; Validated; Region: PRK08605 568703005717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005718 hypothetical protein; Validated; Region: PRK07682 568703005719 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703005720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703005721 homodimer interface [polypeptide binding]; other site 568703005722 catalytic residue [active] 568703005723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703005724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 568703005725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 568703005726 Protein of unknown function DUF124; Region: DUF124; cl00884 568703005727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703005728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703005729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703005730 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703005731 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703005732 Transposase domain (DUF772); Region: DUF772; cl12084 568703005733 Cation efflux family; Region: Cation_efflux; cl00316 568703005734 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 568703005735 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 568703005736 active site 568703005737 dimer interface [polypeptide binding]; other site 568703005738 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 568703005739 Ligand Binding Site [chemical binding]; other site 568703005740 Molecular Tunnel; other site 568703005741 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 568703005742 conserved cys residue [active] 568703005743 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 568703005744 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703005745 active site 568703005746 metal binding site [ion binding]; metal-binding site 568703005747 UbiA prenyltransferase family; Region: UbiA; cl00337 568703005748 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 568703005749 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703005750 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703005751 substrate binding pocket [chemical binding]; other site 568703005752 chain length determination region; other site 568703005753 substrate-Mg2+ binding site; other site 568703005754 catalytic residues [active] 568703005755 aspartate-rich region 1; other site 568703005756 active site lid residues [active] 568703005757 aspartate-rich region 2; other site 568703005758 Acetokinase family; Region: Acetate_kinase; cl01029 568703005759 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 568703005760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005761 Walker A/P-loop; other site 568703005762 ATP binding site [chemical binding]; other site 568703005763 Q-loop/lid; other site 568703005764 ABC transporter signature motif; other site 568703005765 Walker B; other site 568703005766 D-loop; other site 568703005767 H-loop/switch region; other site 568703005768 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 568703005769 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703005770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005771 DNA-binding site [nucleotide binding]; DNA binding site 568703005772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703005773 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703005774 Walker A/P-loop; other site 568703005775 ATP binding site [chemical binding]; other site 568703005776 Q-loop/lid; other site 568703005777 ABC transporter signature motif; other site 568703005778 Walker B; other site 568703005779 D-loop; other site 568703005780 H-loop/switch region; other site 568703005781 glucose-1-dehydrogenase; Provisional; Region: PRK08936 568703005782 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 568703005783 NAD binding site [chemical binding]; other site 568703005784 homodimer interface [polypeptide binding]; other site 568703005785 active site 568703005786 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703005787 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703005788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703005789 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 568703005790 active site turn [active] 568703005791 phosphorylation site [posttranslational modification] 568703005792 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703005793 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 568703005794 HPr interaction site; other site 568703005795 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703005796 active site 568703005797 phosphorylation site [posttranslational modification] 568703005798 transcriptional antiterminator BglG; Provisional; Region: PRK09772 568703005799 CAT RNA binding domain; Region: CAT_RBD; cl03904 568703005800 PRD domain; Region: PRD; pfam00874 568703005801 PRD domain; Region: PRD; pfam00874 568703005802 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005803 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703005804 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 568703005805 Walker A/P-loop; other site 568703005806 ATP binding site [chemical binding]; other site 568703005807 Q-loop/lid; other site 568703005808 ABC transporter signature motif; other site 568703005809 Walker B; other site 568703005810 D-loop; other site 568703005811 H-loop/switch region; other site 568703005812 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703005813 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005815 Walker A/P-loop; other site 568703005816 ATP binding site [chemical binding]; other site 568703005817 Q-loop/lid; other site 568703005818 ABC transporter signature motif; other site 568703005819 Walker B; other site 568703005820 D-loop; other site 568703005821 H-loop/switch region; other site 568703005822 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703005823 trimer interface [polypeptide binding]; other site 568703005824 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cl09913 568703005825 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 568703005826 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 568703005827 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 568703005828 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 568703005829 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 568703005830 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005831 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 568703005832 Walker A/P-loop; other site 568703005833 ATP binding site [chemical binding]; other site 568703005834 Q-loop/lid; other site 568703005835 ABC transporter signature motif; other site 568703005836 Walker B; other site 568703005837 D-loop; other site 568703005838 H-loop/switch region; other site 568703005839 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 568703005840 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703005841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005842 Walker A/P-loop; other site 568703005843 ATP binding site [chemical binding]; other site 568703005844 Q-loop/lid; other site 568703005845 ABC transporter signature motif; other site 568703005846 Walker B; other site 568703005847 D-loop; other site 568703005848 H-loop/switch region; other site 568703005849 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 568703005850 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 568703005851 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 568703005852 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 568703005853 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 568703005854 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 568703005855 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 568703005856 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 568703005857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703005858 active site 568703005859 EamA-like transporter family; Region: EamA; cl01037 568703005860 EamA-like transporter family; Region: EamA; cl01037 568703005861 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 568703005862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 568703005863 Ligand Binding Site [chemical binding]; other site 568703005864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703005865 non-specific DNA binding site [nucleotide binding]; other site 568703005866 salt bridge; other site 568703005867 sequence-specific DNA binding site [nucleotide binding]; other site 568703005868 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 568703005869 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 568703005870 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 568703005871 BioY family; Region: BioY; cl00560 568703005872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703005873 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703005874 catalytic triad [active] 568703005875 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 568703005876 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 568703005877 Domain of unknown function DUF21; Region: DUF21; pfam01595 568703005878 FOG: CBS domain [General function prediction only]; Region: COG0517 568703005879 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 568703005880 Transporter associated domain; Region: CorC_HlyC; cl08393 568703005881 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703005882 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 568703005883 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703005884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703005885 Maf-like protein; Region: Maf; pfam02545 568703005886 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 568703005887 active site 568703005888 dimer interface [polypeptide binding]; other site 568703005889 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 568703005890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703005891 ATP binding site [chemical binding]; other site 568703005892 Mg2+ binding site [ion binding]; other site 568703005893 G-X-G motif; other site 568703005894 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 568703005895 ATP binding site [chemical binding]; other site 568703005896 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 568703005897 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 568703005898 MutS domain I; Region: MutS_I; pfam01624 568703005899 MutS domain II; Region: MutS_II; pfam05188 568703005900 MutS family domain IV; Region: MutS_IV; pfam05190 568703005901 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 568703005902 Walker A/P-loop; other site 568703005903 ATP binding site [chemical binding]; other site 568703005904 Q-loop/lid; other site 568703005905 ABC transporter signature motif; other site 568703005906 Walker B; other site 568703005907 D-loop; other site 568703005908 H-loop/switch region; other site 568703005909 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 568703005910 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 568703005911 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 568703005912 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 568703005913 ring oligomerisation interface [polypeptide binding]; other site 568703005914 ATP/Mg binding site [chemical binding]; other site 568703005915 stacking interactions; other site 568703005916 hinge regions; other site 568703005917 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 568703005918 oligomerisation interface [polypeptide binding]; other site 568703005919 mobile loop; other site 568703005920 roof hairpin; other site 568703005921 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703005922 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 568703005923 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703005924 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703005925 Walker A/P-loop; other site 568703005926 ATP binding site [chemical binding]; other site 568703005927 Q-loop/lid; other site 568703005928 ABC transporter signature motif; other site 568703005929 Walker B; other site 568703005930 D-loop; other site 568703005931 H-loop/switch region; other site 568703005932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703005933 DNA-binding site [nucleotide binding]; DNA binding site 568703005934 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 568703005935 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 568703005936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703005937 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 568703005938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005939 Walker A/P-loop; other site 568703005940 ATP binding site [chemical binding]; other site 568703005941 Q-loop/lid; other site 568703005942 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703005943 ABC transporter signature motif; other site 568703005944 Walker B; other site 568703005945 D-loop; other site 568703005946 ABC transporter; Region: ABC_tran_2; pfam12848 568703005947 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 568703005948 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703005949 active site 568703005950 P-loop; other site 568703005951 phosphorylation site [posttranslational modification] 568703005952 UGMP family protein; Validated; Region: PRK09604 568703005953 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 568703005954 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 568703005955 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 568703005956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703005957 Coenzyme A binding pocket [chemical binding]; other site 568703005958 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 568703005959 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 568703005960 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 568703005961 active site/substrate binding site [active] 568703005962 tetramer interface [polypeptide binding]; other site 568703005963 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 568703005964 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 568703005965 active site 568703005966 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 568703005967 Predicted methyltransferases [General function prediction only]; Region: COG0313 568703005968 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 568703005969 Protein of unknown function (DUF972); Region: DUF972; cl01853 568703005970 DNA polymerase III subunit delta'; Validated; Region: PRK08058 568703005971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703005972 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 568703005973 thymidylate kinase; Validated; Region: tmk; PRK00698 568703005974 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 568703005975 TMP-binding site; other site 568703005976 ATP-binding site [chemical binding]; other site 568703005977 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 568703005978 recombination protein RecR; Reviewed; Region: recR; PRK00076 568703005979 RecR protein; Region: RecR; pfam02132 568703005980 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 568703005981 putative active site [active] 568703005982 putative metal-binding site [ion binding]; other site 568703005983 tetramer interface [polypeptide binding]; other site 568703005984 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 568703005985 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 568703005986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703005987 Walker A motif; other site 568703005988 ATP binding site [chemical binding]; other site 568703005989 Walker B motif; other site 568703005990 arginine finger; other site 568703005991 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 568703005992 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 568703005993 nucleoside/Zn binding site; other site 568703005994 dimer interface [polypeptide binding]; other site 568703005995 catalytic motif [active] 568703005996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 568703005997 S-adenosylmethionine binding site [chemical binding]; other site 568703005998 Predicted integral membrane protein [Function unknown]; Region: COG0392 568703005999 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 568703006000 Uncharacterized conserved protein [Function unknown]; Region: COG2898 568703006001 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 568703006002 Transcriptional regulators [Transcription]; Region: PurR; COG1609 568703006003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 568703006004 DNA binding site [nucleotide binding] 568703006005 domain linker motif; other site 568703006006 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 568703006007 putative dimerization interface [polypeptide binding]; other site 568703006008 putative ligand binding site [chemical binding]; other site 568703006009 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006010 putative active site [active] 568703006011 catalytic triad [active] 568703006012 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703006013 putative active site [active] 568703006014 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703006015 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 568703006016 PPIC-type PPIASE domain; Region: Rotamase; cl08278 568703006017 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 568703006018 core dimer interface [polypeptide binding]; other site 568703006019 peripheral dimer interface [polypeptide binding]; other site 568703006020 L10 interface [polypeptide binding]; other site 568703006021 L11 interface [polypeptide binding]; other site 568703006022 putative EF-Tu interaction site [polypeptide binding]; other site 568703006023 putative EF-G interaction site [polypeptide binding]; other site 568703006024 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 568703006025 23S rRNA interface [nucleotide binding]; other site 568703006026 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 568703006027 drug efflux system protein MdtG; Provisional; Region: PRK09874 568703006028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006029 putative substrate translocation pore; other site 568703006030 benzoate transport; Region: 2A0115; TIGR00895 568703006031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006032 putative substrate translocation pore; other site 568703006033 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 568703006035 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 568703006036 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 568703006037 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 568703006038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 568703006039 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 568703006040 NAD(P) binding site [chemical binding]; other site 568703006041 catalytic residues [active] 568703006042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703006043 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 568703006044 mRNA/rRNA interface [nucleotide binding]; other site 568703006045 Ribosomal protein L11/L12; Region: RL11; smart00649 568703006046 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 568703006047 23S rRNA interface [nucleotide binding]; other site 568703006048 L7/L12 interface [polypeptide binding]; other site 568703006049 putative thiostrepton binding site; other site 568703006050 L25 interface [polypeptide binding]; other site 568703006051 magnesium-transporting ATPase; Provisional; Region: PRK15122 568703006052 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703006053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703006055 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006056 amidase; Provisional; Region: PRK06529 568703006057 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 568703006058 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 568703006059 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 568703006060 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 568703006061 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 568703006062 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 568703006063 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 568703006064 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 568703006065 putative homodimer interface [polypeptide binding]; other site 568703006066 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 568703006067 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 568703006068 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 568703006069 UbiA prenyltransferase family; Region: UbiA; cl00337 568703006070 UbiA prenyltransferase family; Region: UbiA; cl00337 568703006071 ApbE family; Region: ApbE; cl00643 568703006072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 568703006073 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 568703006074 Probable transposase; Region: OrfB_IS605; pfam01385 568703006075 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 568703006076 FMN-binding domain; Region: FMN_bind; cl01081 568703006077 FMN-binding domain; Region: FMN_bind; cl01081 568703006078 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703006079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006080 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 568703006081 trimer interface [polypeptide binding]; other site 568703006082 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 568703006083 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 568703006084 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 568703006085 substrate binding pocket [chemical binding]; other site 568703006086 chain length determination region; other site 568703006087 substrate-Mg2+ binding site; other site 568703006088 catalytic residues [active] 568703006089 aspartate-rich region 1; other site 568703006090 active site lid residues [active] 568703006091 aspartate-rich region 2; other site 568703006092 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 568703006093 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 568703006094 active site 568703006095 metal binding site [ion binding]; metal-binding site 568703006096 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006097 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 568703006098 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 568703006099 Walker A/P-loop; other site 568703006100 ATP binding site [chemical binding]; other site 568703006101 Q-loop/lid; other site 568703006102 ABC transporter signature motif; other site 568703006103 Walker B; other site 568703006104 D-loop; other site 568703006105 H-loop/switch region; other site 568703006106 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 568703006107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 568703006110 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 568703006111 YacP-like NYN domain; Region: NYN_YacP; cl01491 568703006112 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 568703006113 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 568703006114 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 568703006115 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 568703006116 active site 568703006117 metal binding site [ion binding]; metal-binding site 568703006118 dimerization interface [polypeptide binding]; other site 568703006119 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 568703006120 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006121 active site 568703006122 HIGH motif; other site 568703006123 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 568703006124 KMSKS motif; other site 568703006125 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 568703006126 tRNA binding surface [nucleotide binding]; other site 568703006127 anticodon binding site; other site 568703006128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703006129 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006130 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 568703006131 FAD binding domain; Region: FAD_binding_4; pfam01565 568703006132 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 568703006133 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006134 active site 568703006135 HIGH motif; other site 568703006136 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 568703006137 active site 568703006138 KMSKS motif; other site 568703006139 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 568703006140 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 568703006141 Predicted transcriptional regulators [Transcription]; Region: COG1725 568703006142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006143 DNA-binding site [nucleotide binding]; DNA binding site 568703006144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006146 Walker A/P-loop; other site 568703006147 ATP binding site [chemical binding]; other site 568703006148 Q-loop/lid; other site 568703006149 ABC transporter signature motif; other site 568703006150 Walker B; other site 568703006151 D-loop; other site 568703006152 H-loop/switch region; other site 568703006153 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703006154 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703006155 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 568703006156 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 568703006157 putative active site [active] 568703006158 DNA repair protein RadA; Provisional; Region: PRK11823 568703006159 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 568703006160 Walker A motif/ATP binding site; other site 568703006161 ATP binding site [chemical binding]; other site 568703006162 Walker B motif; other site 568703006163 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 568703006164 trimer interface [polypeptide binding]; other site 568703006165 active site 568703006166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703006167 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 568703006168 trimer interface [polypeptide binding]; other site 568703006169 active site 568703006170 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 568703006171 trimer interface [polypeptide binding]; other site 568703006172 active site 568703006173 G bulge; other site 568703006174 Domain of unknown function (DUF373); Region: DUF373; cl12079 568703006175 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 568703006176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006177 Walker A/P-loop; other site 568703006178 ATP binding site [chemical binding]; other site 568703006179 Q-loop/lid; other site 568703006180 ABC transporter signature motif; other site 568703006181 Walker B; other site 568703006182 D-loop; other site 568703006183 H-loop/switch region; other site 568703006184 K+ potassium transporter; Region: K_trans; cl01227 568703006185 pyruvate phosphate dikinase; Provisional; Region: PRK09279 568703006186 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 568703006187 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 568703006188 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 568703006189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 568703006191 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703006192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006193 catalytic core [active] 568703006194 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006195 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 568703006196 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 568703006197 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both...; Region: LOX_like_FMN; cd04737 568703006198 teramer interface [polypeptide binding]; other site 568703006199 active site 568703006200 FMN binding site [chemical binding]; other site 568703006201 catalytic residues [active] 568703006202 CsbD-like; Region: CsbD; cl01272 568703006203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006204 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006205 putative substrate translocation pore; other site 568703006206 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 568703006207 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 568703006208 putative catalytic cysteine [active] 568703006209 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 568703006210 nucleotide binding site [chemical binding]; other site 568703006211 homotetrameric interface [polypeptide binding]; other site 568703006212 putative phosphate binding site [ion binding]; other site 568703006213 putative allosteric binding site; other site 568703006214 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 568703006215 active site 568703006216 catalytic site [active] 568703006217 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 568703006218 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 568703006219 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 568703006220 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 568703006221 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 568703006222 Uncharacterized conserved protein [Function unknown]; Region: COG3410 568703006223 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 568703006224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006225 non-specific DNA binding site [nucleotide binding]; other site 568703006226 salt bridge; other site 568703006227 sequence-specific DNA binding site [nucleotide binding]; other site 568703006228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006229 hypothetical protein; Validated; Region: PRK07668 568703006230 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006231 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 568703006232 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703006233 active site 568703006234 catalytic tetrad [active] 568703006235 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703006236 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703006237 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703006238 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 568703006239 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 568703006240 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 568703006241 putative active site [active] 568703006242 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703006243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006244 Walker A/P-loop; other site 568703006245 ATP binding site [chemical binding]; other site 568703006246 Q-loop/lid; other site 568703006247 ABC transporter signature motif; other site 568703006248 Walker B; other site 568703006249 D-loop; other site 568703006250 H-loop/switch region; other site 568703006251 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 568703006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568703006253 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703006254 LytTr DNA-binding domain; Region: LytTR; cl04498 568703006255 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703006256 Predicted transcriptional regulator [Transcription]; Region: COG1959 568703006257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006260 putative substrate translocation pore; other site 568703006261 Enterocin A Immunity; Region: EntA_Immun; pfam08951 568703006262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703006263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006264 active site 568703006265 catalytic tetrad [active] 568703006266 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 568703006267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006268 NAD(P) binding site [chemical binding]; other site 568703006269 active site 568703006270 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 568703006271 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 568703006272 putative active site [active] 568703006273 putative FMN binding site [chemical binding]; other site 568703006274 putative substrate binding site [chemical binding]; other site 568703006275 putative catalytic residue [active] 568703006276 fumarate hydratase; Reviewed; Region: fumC; PRK00485 568703006277 Class II fumarases; Region: Fumarase_classII; cd01362 568703006278 active site 568703006279 tetramer interface [polypeptide binding]; other site 568703006280 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 568703006281 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 568703006282 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 568703006283 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703006284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703006285 motif II; other site 568703006286 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 568703006287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006288 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703006289 putative substrate translocation pore; other site 568703006290 multicopper oxidase; Provisional; Region: PRK10965 568703006291 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 568703006292 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 568703006293 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006294 Cation efflux family; Region: Cation_efflux; cl00316 568703006295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006296 dimerization interface [polypeptide binding]; other site 568703006297 putative DNA binding site [nucleotide binding]; other site 568703006298 putative Zn2+ binding site [ion binding]; other site 568703006299 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 568703006300 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006301 metal binding site [ion binding]; metal-binding site 568703006302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 568703006303 ABC-ATPase subunit interface; other site 568703006304 dimer interface [polypeptide binding]; other site 568703006305 putative PBP binding regions; other site 568703006306 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 568703006307 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 568703006308 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 568703006309 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 568703006310 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006311 intersubunit interface [polypeptide binding]; other site 568703006312 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 568703006313 putative NAD(P) binding site [chemical binding]; other site 568703006314 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 568703006315 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 568703006316 metal binding site [ion binding]; metal-binding site 568703006317 CrcB-like protein; Region: CRCB; cl09114 568703006318 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 568703006319 putative transporter; Provisional; Region: PRK11462 568703006320 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 568703006321 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 568703006322 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 568703006323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703006324 substrate binding pocket [chemical binding]; other site 568703006325 membrane-bound complex binding site; other site 568703006326 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 568703006327 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 568703006328 Acyltransferase family; Region: Acyl_transf_3; pfam01757 568703006329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006330 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 568703006331 Walker A/P-loop; other site 568703006332 ATP binding site [chemical binding]; other site 568703006333 Q-loop/lid; other site 568703006334 ABC transporter signature motif; other site 568703006335 Walker B; other site 568703006336 D-loop; other site 568703006337 H-loop/switch region; other site 568703006338 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 568703006339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703006340 putative PBP binding loops; other site 568703006341 dimer interface [polypeptide binding]; other site 568703006342 ABC-ATPase subunit interface; other site 568703006343 B3/4 domain; Region: B3_4; cl11458 568703006344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006346 Walker A/P-loop; other site 568703006347 ATP binding site [chemical binding]; other site 568703006348 Q-loop/lid; other site 568703006349 ABC transporter signature motif; other site 568703006350 Walker B; other site 568703006351 D-loop; other site 568703006352 H-loop/switch region; other site 568703006353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006355 Walker A/P-loop; other site 568703006356 ATP binding site [chemical binding]; other site 568703006357 Q-loop/lid; other site 568703006358 ABC transporter signature motif; other site 568703006359 Walker B; other site 568703006360 D-loop; other site 568703006361 H-loop/switch region; other site 568703006362 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703006363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006364 putative substrate translocation pore; other site 568703006365 putative transposase OrfB; Reviewed; Region: PHA02517 568703006366 Integrase core domain; Region: rve; cl01316 568703006367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703006368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703006369 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 568703006370 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 568703006371 23S rRNA interface [nucleotide binding]; other site 568703006372 L3 interface [polypeptide binding]; other site 568703006373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 568703006374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 568703006375 FtsX-like permease family; Region: FtsX; pfam02687 568703006376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703006377 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703006378 Walker A/P-loop; other site 568703006379 ATP binding site [chemical binding]; other site 568703006380 Q-loop/lid; other site 568703006381 ABC transporter signature motif; other site 568703006382 Walker B; other site 568703006383 D-loop; other site 568703006384 H-loop/switch region; other site 568703006385 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 568703006386 DNA binding residues [nucleotide binding] 568703006387 dimer interface [polypeptide binding]; other site 568703006388 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 568703006389 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 568703006390 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 568703006391 dimerization interface 3.5A [polypeptide binding]; other site 568703006392 active site 568703006393 Cobalt transport protein; Region: CbiQ; cl00463 568703006394 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 568703006395 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006396 Walker A/P-loop; other site 568703006397 ATP binding site [chemical binding]; other site 568703006398 Q-loop/lid; other site 568703006399 ABC transporter signature motif; other site 568703006400 Walker B; other site 568703006401 D-loop; other site 568703006402 H-loop/switch region; other site 568703006403 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 568703006404 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 568703006405 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006406 Walker A/P-loop; other site 568703006407 ATP binding site [chemical binding]; other site 568703006408 Q-loop/lid; other site 568703006409 ABC transporter signature motif; other site 568703006410 Walker B; other site 568703006411 D-loop; other site 568703006412 H-loop/switch region; other site 568703006413 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 568703006414 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 568703006415 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 568703006416 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 568703006417 alphaNTD homodimer interface [polypeptide binding]; other site 568703006418 alphaNTD - beta interaction site [polypeptide binding]; other site 568703006419 alphaNTD - beta' interaction site [polypeptide binding]; other site 568703006420 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 568703006421 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 568703006422 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 568703006423 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 568703006424 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 568703006425 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 568703006426 rRNA binding site [nucleotide binding]; other site 568703006427 predicted 30S ribosome binding site; other site 568703006428 adenylate kinase; Reviewed; Region: adk; PRK00279 568703006429 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 568703006430 AMP-binding site [chemical binding]; other site 568703006431 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 568703006432 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 568703006433 SecY translocase; Region: SecY; pfam00344 568703006434 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 568703006435 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 568703006436 23S rRNA binding site [nucleotide binding]; other site 568703006437 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 568703006438 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 568703006439 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 568703006440 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 568703006441 5S rRNA interface [nucleotide binding]; other site 568703006442 L27 interface [polypeptide binding]; other site 568703006443 23S rRNA interface [nucleotide binding]; other site 568703006444 L5 interface [polypeptide binding]; other site 568703006445 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 568703006446 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006447 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 568703006448 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 568703006449 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 568703006450 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 568703006451 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 568703006452 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 568703006453 KOW motif; Region: KOW; cl00354 568703006454 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 568703006455 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 568703006456 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 568703006457 23S rRNA interface [nucleotide binding]; other site 568703006458 putative translocon interaction site; other site 568703006459 signal recognition particle (SRP54) interaction site; other site 568703006460 L23 interface [polypeptide binding]; other site 568703006461 trigger factor interaction site; other site 568703006462 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 568703006463 23S rRNA interface [nucleotide binding]; other site 568703006464 5S rRNA interface [nucleotide binding]; other site 568703006465 putative antibiotic binding site [chemical binding]; other site 568703006466 L25 interface [polypeptide binding]; other site 568703006467 L27 interface [polypeptide binding]; other site 568703006468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 568703006469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 568703006470 G-X-X-G motif; other site 568703006471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 568703006472 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 568703006473 putative translocon binding site; other site 568703006474 protein-rRNA interface [nucleotide binding]; other site 568703006475 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 568703006476 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 568703006477 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 568703006478 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 568703006479 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 568703006480 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 568703006481 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 568703006482 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 568703006483 Phosphate-starvation-inducible E; Region: PsiE; cl01264 568703006484 peroxiredoxin; Region: AhpC; TIGR03137 568703006485 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 568703006486 dimer interface [polypeptide binding]; other site 568703006487 decamer (pentamer of dimers) interface [polypeptide binding]; other site 568703006488 catalytic triad [active] 568703006489 peroxidatic and resolving cysteines [active] 568703006490 Predicted transcriptional regulator [Transcription]; Region: COG2378 568703006491 elongation factor G; Reviewed; Region: PRK12739 568703006492 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 568703006493 G1 box; other site 568703006494 putative GEF interaction site [polypeptide binding]; other site 568703006495 GTP/Mg2+ binding site [chemical binding]; other site 568703006496 Switch I region; other site 568703006497 G2 box; other site 568703006498 G3 box; other site 568703006499 Switch II region; other site 568703006500 G4 box; other site 568703006501 G5 box; other site 568703006502 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 568703006503 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 568703006504 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 568703006505 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 568703006506 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 568703006507 S17 interaction site [polypeptide binding]; other site 568703006508 S8 interaction site; other site 568703006509 16S rRNA interaction site [nucleotide binding]; other site 568703006510 streptomycin interaction site [chemical binding]; other site 568703006511 23S rRNA interaction site [nucleotide binding]; other site 568703006512 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 568703006513 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 568703006514 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 568703006515 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 568703006516 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 568703006517 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 568703006518 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 568703006519 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 568703006520 DNA binding site [nucleotide binding] 568703006521 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 568703006522 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 568703006523 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 568703006524 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 568703006525 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568703006526 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 568703006527 RPB1 interaction site [polypeptide binding]; other site 568703006528 RPB10 interaction site [polypeptide binding]; other site 568703006529 RPB11 interaction site [polypeptide binding]; other site 568703006530 RPB3 interaction site [polypeptide binding]; other site 568703006531 RPB12 interaction site [polypeptide binding]; other site 568703006532 Clp protease ATP binding subunit; Region: clpC; CHL00095 568703006533 Clp amino terminal domain; Region: Clp_N; pfam02861 568703006534 Clp amino terminal domain; Region: Clp_N; pfam02861 568703006535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703006536 Walker A motif; other site 568703006537 ATP binding site [chemical binding]; other site 568703006538 Walker B motif; other site 568703006539 arginine finger; other site 568703006540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703006541 Walker A motif; other site 568703006542 ATP binding site [chemical binding]; other site 568703006543 Walker B motif; other site 568703006544 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 568703006545 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 568703006546 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 568703006547 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 568703006548 dimer interface [polypeptide binding]; other site 568703006549 putative anticodon binding site; other site 568703006550 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 568703006551 motif 1; other site 568703006552 active site 568703006553 motif 2; other site 568703006554 motif 3; other site 568703006555 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 568703006556 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 568703006557 FMN binding site [chemical binding]; other site 568703006558 active site 568703006559 catalytic residues [active] 568703006560 substrate binding site [chemical binding]; other site 568703006561 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 568703006562 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 568703006563 dimerization interface [polypeptide binding]; other site 568703006564 domain crossover interface; other site 568703006565 redox-dependent activation switch; other site 568703006566 FtsH Extracellular; Region: FtsH_ext; pfam06480 568703006567 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 568703006568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703006569 Walker A motif; other site 568703006570 ATP binding site [chemical binding]; other site 568703006571 Walker B motif; other site 568703006572 arginine finger; other site 568703006573 Peptidase family M41; Region: Peptidase_M41; pfam01434 568703006574 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703006575 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 568703006576 Ligand Binding Site [chemical binding]; other site 568703006577 B3/4 domain; Region: B3_4; cl11458 568703006578 hypothetical protein; Provisional; Region: PRK08582 568703006579 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 568703006580 RNA binding site [nucleotide binding]; other site 568703006581 Septum formation initiator; Region: DivIC; cl11433 568703006582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 568703006583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 568703006584 MatE; Region: MatE; cl10513 568703006585 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 568703006586 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 568703006587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 568703006588 ATP binding site [chemical binding]; other site 568703006589 putative Mg++ binding site [ion binding]; other site 568703006590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703006591 nucleotide binding region [chemical binding]; other site 568703006592 ATP-binding site [chemical binding]; other site 568703006593 TRCF domain; Region: TRCF; cl04088 568703006594 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 568703006595 putative active site [active] 568703006596 catalytic residue [active] 568703006597 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 568703006598 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 568703006599 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703006600 NAD binding site [chemical binding]; other site 568703006601 dimer interface [polypeptide binding]; other site 568703006602 substrate binding site [chemical binding]; other site 568703006603 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703006604 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 568703006605 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703006606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006607 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 568703006608 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 568703006609 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 568703006610 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 568703006611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 568703006612 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 568703006613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006614 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 568703006615 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 568703006616 active site 568703006617 dimer interface [polypeptide binding]; other site 568703006618 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 568703006619 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 568703006620 active site 568703006621 FMN binding site [chemical binding]; other site 568703006622 substrate binding site [chemical binding]; other site 568703006623 3Fe-4S cluster binding site [ion binding]; other site 568703006624 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 568703006625 domain interface; other site 568703006626 QueT transporter; Region: QueT; cl01932 568703006627 PemK-like protein; Region: PemK; cl00995 568703006628 hypothetical protein; Region: PHA01623 568703006629 alanine racemase; Reviewed; Region: alr; PRK00053 568703006630 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 568703006631 active site 568703006632 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 568703006633 dimer interface [polypeptide binding]; other site 568703006634 substrate binding site [chemical binding]; other site 568703006635 catalytic residues [active] 568703006636 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 568703006637 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 568703006638 DEAD-like helicases superfamily; Region: DEXDc; smart00487 568703006639 ATP binding site [chemical binding]; other site 568703006640 Mg++ binding site [ion binding]; other site 568703006641 motif III; other site 568703006642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 568703006643 nucleotide binding region [chemical binding]; other site 568703006644 ATP-binding site [chemical binding]; other site 568703006645 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 568703006646 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 568703006647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 568703006648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 568703006649 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 568703006650 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 568703006651 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 568703006652 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 568703006653 hinge; other site 568703006654 active site 568703006655 CTP synthetase; Validated; Region: pyrG; PRK05380 568703006656 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 568703006657 Catalytic site [active] 568703006658 Active site [active] 568703006659 UTP binding site [chemical binding]; other site 568703006660 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 568703006661 active site 568703006662 putative oxyanion hole; other site 568703006663 catalytic triad [active] 568703006664 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 568703006665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006666 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703006667 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 568703006668 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 568703006669 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 568703006670 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 568703006671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 568703006672 Zn2+ binding site [ion binding]; other site 568703006673 Mg2+ binding site [ion binding]; other site 568703006674 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684 568703006675 nudix motif; other site 568703006676 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 568703006677 putative active site [active] 568703006678 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 568703006679 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 568703006680 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 568703006681 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703006682 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 568703006683 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 568703006684 Substrate binding site [chemical binding]; other site 568703006685 Mg++ binding site [ion binding]; other site 568703006686 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 568703006687 active site 568703006688 substrate binding site [chemical binding]; other site 568703006689 CoA binding site [chemical binding]; other site 568703006690 VanZ like family; Region: VanZ; cl01971 568703006691 RDD family; Region: RDD; cl00746 568703006692 pur operon repressor; Provisional; Region: PRK09213 568703006693 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 568703006694 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703006695 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 568703006696 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 568703006697 Walker A/P-loop; other site 568703006698 ATP binding site [chemical binding]; other site 568703006699 Q-loop/lid; other site 568703006700 ABC transporter signature motif; other site 568703006701 Walker B; other site 568703006702 D-loop; other site 568703006703 H-loop/switch region; other site 568703006704 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 568703006705 Cation efflux family; Region: Cation_efflux; cl00316 568703006706 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 568703006707 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 568703006708 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 568703006709 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 568703006710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703006711 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 568703006712 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 568703006713 putative active site [active] 568703006714 putative metal binding site [ion binding]; other site 568703006715 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 568703006716 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 568703006717 active site 568703006718 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703006719 active site 568703006720 phosphorylation site [posttranslational modification] 568703006721 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703006722 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 568703006723 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 568703006724 active site 568703006725 catalytic residues [active] 568703006726 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 568703006727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703006728 active site 568703006729 phosphorylation site [posttranslational modification] 568703006730 intermolecular recognition site; other site 568703006731 dimerization interface [polypeptide binding]; other site 568703006732 LytTr DNA-binding domain; Region: LytTR; cl04498 568703006733 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 568703006734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 568703006735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006737 Walker A/P-loop; other site 568703006738 ATP binding site [chemical binding]; other site 568703006739 Q-loop/lid; other site 568703006740 ABC transporter signature motif; other site 568703006741 Walker B; other site 568703006742 D-loop; other site 568703006743 H-loop/switch region; other site 568703006744 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 568703006745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006746 Walker A/P-loop; other site 568703006747 ATP binding site [chemical binding]; other site 568703006748 Q-loop/lid; other site 568703006749 ABC transporter signature motif; other site 568703006750 Walker B; other site 568703006751 D-loop; other site 568703006752 H-loop/switch region; other site 568703006753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703006754 non-specific DNA binding site [nucleotide binding]; other site 568703006755 salt bridge; other site 568703006756 sequence-specific DNA binding site [nucleotide binding]; other site 568703006757 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 568703006758 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 568703006759 active site 568703006760 HIGH motif; other site 568703006761 KMSKS motif; other site 568703006762 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 568703006763 tRNA binding surface [nucleotide binding]; other site 568703006764 anticodon binding site; other site 568703006765 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 568703006766 dimer interface [polypeptide binding]; other site 568703006767 putative tRNA-binding site [nucleotide binding]; other site 568703006768 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 568703006769 Protein of unknown function DUF72; Region: DUF72; cl00777 568703006770 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 568703006771 putative active site [active] 568703006772 nucleotide binding site [chemical binding]; other site 568703006773 nudix motif; other site 568703006774 putative metal binding site [ion binding]; other site 568703006775 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 568703006776 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 568703006777 LDH/MDH dimer interface [polypeptide binding]; other site 568703006778 NAD(P) binding site [chemical binding]; other site 568703006779 substrate binding site [chemical binding]; other site 568703006780 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 568703006781 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 568703006782 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 568703006783 substrate binding site [chemical binding]; other site 568703006784 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 568703006785 exopolyphosphatase; Region: exo_poly_only; TIGR03706 568703006786 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703006787 Polyphosphate kinase; Region: PP_kinase; pfam02503 568703006788 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 568703006789 putative domain interface [polypeptide binding]; other site 568703006790 putative active site [active] 568703006791 catalytic site [active] 568703006792 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 568703006793 putative domain interface [polypeptide binding]; other site 568703006794 putative active site [active] 568703006795 catalytic site [active] 568703006796 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 568703006797 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 568703006798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703006799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703006800 active site 568703006801 catalytic tetrad [active] 568703006802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 568703006803 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568703006804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703006805 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 568703006806 MatE; Region: MatE; cl10513 568703006807 MatE; Region: MatE; cl10513 568703006808 Domain of unknown function (DUF477); Region: DUF477; cl01535 568703006809 LemA family; Region: LemA; cl00742 568703006810 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 568703006811 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 568703006812 active site 568703006813 HIGH motif; other site 568703006814 dimer interface [polypeptide binding]; other site 568703006815 KMSKS motif; other site 568703006816 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 568703006817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006818 Walker A/P-loop; other site 568703006819 ATP binding site [chemical binding]; other site 568703006820 Q-loop/lid; other site 568703006821 ABC transporter signature motif; other site 568703006822 Walker B; other site 568703006823 D-loop; other site 568703006824 H-loop/switch region; other site 568703006825 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 568703006826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703006827 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 568703006828 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 568703006829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006830 Walker A/P-loop; other site 568703006831 ATP binding site [chemical binding]; other site 568703006832 Q-loop/lid; other site 568703006833 ABC transporter signature motif; other site 568703006834 Walker B; other site 568703006835 D-loop; other site 568703006836 H-loop/switch region; other site 568703006837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703006838 dimer interface [polypeptide binding]; other site 568703006839 conserved gate region; other site 568703006840 ABC-ATPase subunit interface; other site 568703006841 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703006842 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 568703006843 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 568703006844 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703006845 UvrD/REP helicase; Region: UvrD-helicase; cl14126 568703006846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703006847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703006849 dimerization interface [polypeptide binding]; other site 568703006850 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 568703006851 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 568703006852 gating phenylalanine in ion channel; other site 568703006853 ABC-2 type transporter; Region: ABC2_membrane; cl11417 568703006854 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 568703006855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006856 Walker A/P-loop; other site 568703006857 ATP binding site [chemical binding]; other site 568703006858 Q-loop/lid; other site 568703006859 ABC transporter signature motif; other site 568703006860 Walker B; other site 568703006861 D-loop; other site 568703006862 H-loop/switch region; other site 568703006863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 568703006864 putative DNA binding site [nucleotide binding]; other site 568703006865 dimerization interface [polypeptide binding]; other site 568703006866 putative Zn2+ binding site [ion binding]; other site 568703006867 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 568703006868 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 568703006869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703006870 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 568703006871 Walker A/P-loop; other site 568703006872 ATP binding site [chemical binding]; other site 568703006873 Q-loop/lid; other site 568703006874 ABC transporter signature motif; other site 568703006875 Walker B; other site 568703006876 D-loop; other site 568703006877 H-loop/switch region; other site 568703006878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 568703006879 Transcriptional regulators [Transcription]; Region: MarR; COG1846 568703006880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006881 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006882 Walker A/P-loop; other site 568703006883 ATP binding site [chemical binding]; other site 568703006884 Q-loop/lid; other site 568703006885 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 568703006886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006887 ABC transporter signature motif; other site 568703006888 Walker B; other site 568703006889 D-loop; other site 568703006890 H-loop/switch region; other site 568703006891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703006892 Walker A/P-loop; other site 568703006893 ATP binding site [chemical binding]; other site 568703006894 Q-loop/lid; other site 568703006895 ABC transporter signature motif; other site 568703006896 Walker B; other site 568703006897 D-loop; other site 568703006898 H-loop/switch region; other site 568703006899 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 568703006900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703006901 active site 568703006902 catalytic tetrad [active] 568703006903 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703006904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703006905 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 568703006906 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 568703006907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 568703006908 catalytic core [active] 568703006909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703006910 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703006911 active site 568703006912 motif I; other site 568703006913 motif II; other site 568703006914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703006915 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 568703006916 RNA/DNA hybrid binding site [nucleotide binding]; other site 568703006917 active site 568703006918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703006919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703006921 dimerization interface [polypeptide binding]; other site 568703006922 hypothetical protein; Validated; Region: PRK07682 568703006923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703006925 homodimer interface [polypeptide binding]; other site 568703006926 catalytic residue [active] 568703006927 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 568703006928 recombinase A; Provisional; Region: recA; PRK09354 568703006929 hexamer interface [polypeptide binding]; other site 568703006930 Walker A motif; other site 568703006931 ATP binding site [chemical binding]; other site 568703006932 Walker B motif; other site 568703006933 Protein of unknown function (DUF554); Region: DUF554; cl00784 568703006934 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 568703006935 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 568703006936 P-loop; other site 568703006937 active site 568703006938 phosphorylation site [posttranslational modification] 568703006939 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703006940 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703006941 active site 568703006942 phosphorylation site [posttranslational modification] 568703006943 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 568703006944 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 568703006945 putative substrate binding site [chemical binding]; other site 568703006946 putative ATP binding site [chemical binding]; other site 568703006947 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703006948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703006949 putative active site [active] 568703006950 glycerol kinase; Provisional; Region: glpK; PRK00047 568703006951 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 568703006952 N- and C-terminal domain interface [polypeptide binding]; other site 568703006953 active site 568703006954 MgATP binding site [chemical binding]; other site 568703006955 catalytic site [active] 568703006956 metal binding site [ion binding]; metal-binding site 568703006957 glycerol binding site [chemical binding]; other site 568703006958 homotetramer interface [polypeptide binding]; other site 568703006959 homodimer interface [polypeptide binding]; other site 568703006960 FBP binding site [chemical binding]; other site 568703006961 protein IIAGlc interface [polypeptide binding]; other site 568703006962 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703006963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703006964 DNA-binding site [nucleotide binding]; DNA binding site 568703006965 UTRA domain; Region: UTRA; cl01230 568703006966 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703006967 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 568703006968 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703006969 active pocket/dimerization site; other site 568703006970 active site 568703006971 phosphorylation site [posttranslational modification] 568703006972 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 568703006973 active site 568703006974 phosphorylation site [posttranslational modification] 568703006975 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703006976 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703006977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 568703006978 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 568703006979 Flavoprotein; Region: Flavoprotein; cl08021 568703006980 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703006981 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703006982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 568703006983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 568703006985 dimerization interface [polypeptide binding]; other site 568703006986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703006987 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703006988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703006989 putative substrate translocation pore; other site 568703006990 galactonate dehydratase; Provisional; Region: PRK14017 568703006991 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 568703006992 putative active site pocket [active] 568703006993 putative metal binding site [ion binding]; other site 568703006994 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703006995 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703006996 P-loop; other site 568703006997 active site 568703006998 phosphorylation site [posttranslational modification] 568703006999 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007000 active site 568703007001 phosphorylation site [posttranslational modification] 568703007002 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 568703007003 active site 568703007004 intersubunit interface [polypeptide binding]; other site 568703007005 catalytic residue [active] 568703007006 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007007 PRD domain; Region: PRD; pfam00874 568703007008 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007009 P-loop; other site 568703007010 active site 568703007011 phosphorylation site [posttranslational modification] 568703007012 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007013 active site 568703007014 phosphorylation site [posttranslational modification] 568703007015 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703007016 active site 568703007017 methionine cluster; other site 568703007018 phosphorylation site [posttranslational modification] 568703007019 metal binding site [ion binding]; metal-binding site 568703007020 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703007021 active site 568703007022 P-loop; other site 568703007023 phosphorylation site [posttranslational modification] 568703007024 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 568703007025 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 568703007026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007027 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 568703007028 Uncharacterized conserved protein [Function unknown]; Region: COG3538 568703007029 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 568703007030 alpha-mannosidase; Provisional; Region: PRK09819 568703007031 Transposase domain (DUF772); Region: DUF772; cl12084 568703007032 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 568703007033 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703007034 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703007035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007037 DNA-binding site [nucleotide binding]; DNA binding site 568703007038 UTRA domain; Region: UTRA; cl01230 568703007039 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007041 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703007042 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 568703007043 active site 568703007044 intersubunit interface [polypeptide binding]; other site 568703007045 Zn2+ binding site [ion binding]; other site 568703007046 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 568703007047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007048 putative substrate translocation pore; other site 568703007049 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 568703007050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007051 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007052 N- and C-terminal domain interface [polypeptide binding]; other site 568703007053 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007054 active site 568703007055 catalytic site [active] 568703007056 metal binding site [ion binding]; metal-binding site 568703007057 ATP binding site [chemical binding]; other site 568703007058 carbohydrate binding site [chemical binding]; other site 568703007059 L-fucose isomerase; Provisional; Region: fucI; PRK10991 568703007060 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 568703007061 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703007062 trimer interface [polypeptide binding]; other site 568703007063 substrate binding site [chemical binding]; other site 568703007064 Mn binding site [ion binding]; other site 568703007065 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 568703007066 intersubunit interface [polypeptide binding]; other site 568703007067 active site 568703007068 Zn2+ binding site [ion binding]; other site 568703007069 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 568703007070 Domain of unknown function (DUF718); Region: DUF718; cl01281 568703007071 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 568703007072 N- and C-terminal domain interface [polypeptide binding]; other site 568703007073 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 568703007074 active site 568703007075 catalytic site [active] 568703007076 metal binding site [ion binding]; metal-binding site 568703007077 ATP binding site [chemical binding]; other site 568703007078 carbohydrate binding site [chemical binding]; other site 568703007079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007080 putative substrate translocation pore; other site 568703007081 Cupin domain; Region: Cupin_2; cl09118 568703007082 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 568703007083 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 568703007084 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 568703007085 catalytic Zn binding site [ion binding]; other site 568703007086 NAD binding site [chemical binding]; other site 568703007087 structural Zn binding site [ion binding]; other site 568703007088 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 568703007089 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 568703007090 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 568703007091 putative transposase OrfB; Reviewed; Region: PHA02517 568703007092 Integrase core domain; Region: rve; cl01316 568703007093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703007094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703007095 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 568703007096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007097 active site 568703007098 dimer interface [polypeptide binding]; other site 568703007099 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 568703007100 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 568703007101 NAD binding site [chemical binding]; other site 568703007102 sugar binding site [chemical binding]; other site 568703007103 divalent metal binding site [ion binding]; other site 568703007104 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 568703007105 dimer interface [polypeptide binding]; other site 568703007106 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 568703007107 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703007108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 568703007109 active site turn [active] 568703007110 phosphorylation site [posttranslational modification] 568703007111 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 568703007112 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703007113 putative active site [active] 568703007114 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 568703007115 HPr interaction site; other site 568703007116 glycerol kinase (GK) interaction site [polypeptide binding]; other site 568703007117 active site 568703007118 phosphorylation site [posttranslational modification] 568703007119 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 568703007120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 568703007121 dihydroorotase; Provisional; Region: PRK09237 568703007122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 568703007123 active site 568703007124 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 568703007125 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 568703007126 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 568703007127 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 568703007128 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 568703007129 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007132 PRD domain; Region: PRD; pfam00874 568703007133 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007134 P-loop; other site 568703007135 active site 568703007136 phosphorylation site [posttranslational modification] 568703007137 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 568703007138 catalytic residue [active] 568703007139 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 568703007140 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 568703007141 IIBC component; Region: EIIBC-GUT; TIGR00825 568703007142 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 568703007143 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 568703007144 Glucitol operon activator protein (GutM); Region: GutM; cl01890 568703007145 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007147 PRD domain; Region: PRD; pfam00874 568703007148 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 568703007150 classical (c) SDRs; Region: SDR_c; cd05233 568703007151 NAD(P) binding site [chemical binding]; other site 568703007152 active site 568703007153 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cd00398 568703007154 intersubunit interface [polypeptide binding]; other site 568703007155 active site 568703007156 Zn2+ binding site [ion binding]; other site 568703007157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703007158 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007159 active site 568703007160 motif I; other site 568703007161 motif II; other site 568703007162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703007163 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 568703007164 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 568703007165 AP (apurinic/apyrimidinic) site pocket; other site 568703007166 DNA interaction; other site 568703007167 Metal-binding active site; metal-binding site 568703007168 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 568703007169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007170 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 568703007171 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 568703007172 active site 568703007173 dimer interface [polypeptide binding]; other site 568703007174 magnesium binding site [ion binding]; other site 568703007175 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 568703007176 P-loop; other site 568703007177 active site 568703007178 phosphorylation site [posttranslational modification] 568703007179 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007181 active site 568703007182 phosphorylation site [posttranslational modification] 568703007183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703007184 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 568703007185 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 568703007186 putative active site [active] 568703007187 catalytic triad [active] 568703007188 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 568703007189 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 568703007190 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 568703007191 Peptidase family M54; Region: Peptidase_M54; cl00835 568703007192 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (...; Region: Glycosylasparaginase; cd04513 568703007193 active site 568703007194 dimer interface [polypeptide binding]; other site 568703007195 catalytic nucleophile [active] 568703007196 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 568703007197 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 568703007198 active site 568703007199 metal binding site [ion binding]; metal-binding site 568703007200 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007202 DNA-binding site [nucleotide binding]; DNA binding site 568703007203 UTRA domain; Region: UTRA; cl01230 568703007204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 568703007206 putative substrate translocation pore; other site 568703007207 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 568703007208 D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803 568703007209 N- and C-terminal domain interface [polypeptide binding]; other site 568703007210 D-xylulose kinase; Region: XylB; TIGR01312 568703007211 active site 568703007212 catalytic site [active] 568703007213 metal binding site [ion binding]; metal-binding site 568703007214 xylulose binding site [chemical binding]; other site 568703007215 ATP binding site [chemical binding]; other site 568703007216 homodimer interface [polypeptide binding]; other site 568703007217 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 568703007218 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 568703007219 NAD(P) binding site [chemical binding]; other site 568703007220 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703007221 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703007222 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 568703007223 active site 568703007224 phosphorylation site [posttranslational modification] 568703007225 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 568703007226 active pocket/dimerization site; other site 568703007227 active site 568703007228 phosphorylation site [posttranslational modification] 568703007229 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007230 active site 568703007231 phosphorylation site [posttranslational modification] 568703007232 Transposase domain (DUF772); Region: DUF772; cl12084 568703007233 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703007234 hypothetical protein; Provisional; Region: PRK08185 568703007235 intersubunit interface [polypeptide binding]; other site 568703007236 active site 568703007237 zinc binding site [ion binding]; other site 568703007238 Na+ binding site [ion binding]; other site 568703007239 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 568703007240 putative N- and C-terminal domain interface [polypeptide binding]; other site 568703007241 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 568703007242 putative active site [active] 568703007243 putative MgATP binding site [chemical binding]; other site 568703007244 catalytic site [active] 568703007245 metal binding site [ion binding]; metal-binding site 568703007246 putative carbohydrate binding site [chemical binding]; other site 568703007247 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 568703007248 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 568703007249 P-loop; other site 568703007250 active site 568703007251 phosphorylation site [posttranslational modification] 568703007252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007253 active site 568703007254 phosphorylation site [posttranslational modification] 568703007255 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 568703007256 hypothetical protein; Provisional; Region: PRK08185 568703007257 intersubunit interface [polypeptide binding]; other site 568703007258 active site 568703007259 zinc binding site [ion binding]; other site 568703007260 Na+ binding site [ion binding]; other site 568703007261 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007263 DNA-binding site [nucleotide binding]; DNA binding site 568703007264 UTRA domain; Region: UTRA; cl01230 568703007265 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703007266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007267 Coenzyme A binding pocket [chemical binding]; other site 568703007268 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 568703007269 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 568703007270 nudix motif; other site 568703007271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007272 non-specific DNA binding site [nucleotide binding]; other site 568703007273 salt bridge; other site 568703007274 sequence-specific DNA binding site [nucleotide binding]; other site 568703007275 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 568703007276 active site 568703007277 catalytic site [active] 568703007278 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02763 568703007279 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 568703007280 Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759 568703007281 putative dockerin binding interface; other site 568703007282 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 568703007283 nudix motif; other site 568703007284 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 568703007285 Isochorismatase family; Region: Isochorismatase; pfam00857 568703007286 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 568703007287 catalytic triad [active] 568703007288 conserved cis-peptide bond; other site 568703007289 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 568703007290 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 568703007291 active site 568703007292 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 568703007293 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 568703007294 active site 568703007295 catalytic site [active] 568703007296 Low molecular weight phosphatase family; Region: LMWPc; cd00115 568703007297 Active site [active] 568703007298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703007299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703007300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 568703007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007302 dimer interface [polypeptide binding]; other site 568703007303 conserved gate region; other site 568703007304 putative PBP binding loops; other site 568703007305 ABC-ATPase subunit interface; other site 568703007306 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 568703007307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007308 dimer interface [polypeptide binding]; other site 568703007309 conserved gate region; other site 568703007310 putative PBP binding loops; other site 568703007311 ABC-ATPase subunit interface; other site 568703007312 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 568703007313 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703007314 Walker A/P-loop; other site 568703007315 ATP binding site [chemical binding]; other site 568703007316 Q-loop/lid; other site 568703007317 ABC transporter signature motif; other site 568703007318 Walker B; other site 568703007319 D-loop; other site 568703007320 H-loop/switch region; other site 568703007321 TOBE domain; Region: TOBE_2; cl01440 568703007322 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703007323 Beta-lactamase; Region: Beta-lactamase; cl01009 568703007324 Beta-lactamase; Region: Beta-lactamase; cl01009 568703007325 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 568703007326 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 568703007327 putative active site [active] 568703007328 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 568703007329 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 568703007330 putative active site [active] 568703007331 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 568703007332 active site 568703007333 phosphorylation site [posttranslational modification] 568703007334 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703007335 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703007336 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 568703007337 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 568703007338 DHH family; Region: DHH; pfam01368 568703007339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703007340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 568703007341 active site 568703007342 catalytic tetrad [active] 568703007343 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 568703007344 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 568703007345 DNA binding residues [nucleotide binding] 568703007346 putative dimer interface [polypeptide binding]; other site 568703007347 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 568703007348 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 568703007349 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 568703007350 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703007351 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 568703007352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703007353 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 568703007354 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 568703007355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 568703007356 Coenzyme A binding pocket [chemical binding]; other site 568703007357 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 568703007358 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 568703007359 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 568703007360 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 568703007361 transmembrane helices; other site 568703007362 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 568703007363 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 568703007364 metal binding site [ion binding]; metal-binding site 568703007365 dimer interface [polypeptide binding]; other site 568703007366 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 568703007367 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 568703007368 peptide binding site [polypeptide binding]; other site 568703007369 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 568703007370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 568703007371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703007372 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 568703007373 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 568703007374 putative dimer interface [polypeptide binding]; other site 568703007375 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 568703007376 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 568703007377 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 568703007378 protein binding site [polypeptide binding]; other site 568703007379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 568703007380 YycH protein; Region: YycI; cl02015 568703007381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 568703007382 YycH protein; Region: YycH; pfam07435 568703007383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 568703007384 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 568703007385 dimerization interface [polypeptide binding]; other site 568703007386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 568703007387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 568703007388 dimer interface [polypeptide binding]; other site 568703007389 phosphorylation site [posttranslational modification] 568703007390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 568703007391 ATP binding site [chemical binding]; other site 568703007392 Mg2+ binding site [ion binding]; other site 568703007393 G-X-G motif; other site 568703007394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 568703007395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703007396 active site 568703007397 phosphorylation site [posttranslational modification] 568703007398 intermolecular recognition site; other site 568703007399 dimerization interface [polypeptide binding]; other site 568703007400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 568703007401 DNA binding site [nucleotide binding] 568703007402 Chlorophyllase; Region: Chlorophyllase; cl15281 568703007403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 568703007404 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703007405 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703007406 substrate binding pocket [chemical binding]; other site 568703007407 membrane-bound complex binding site; other site 568703007408 hinge residues; other site 568703007409 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703007410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007411 dimer interface [polypeptide binding]; other site 568703007412 conserved gate region; other site 568703007413 putative PBP binding loops; other site 568703007414 ABC-ATPase subunit interface; other site 568703007415 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 568703007416 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 568703007417 ANP binding site [chemical binding]; other site 568703007418 Substrate Binding Site II [chemical binding]; other site 568703007419 Substrate Binding Site I [chemical binding]; other site 568703007420 argininosuccinate lyase; Provisional; Region: PRK00855 568703007421 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 568703007422 active sites [active] 568703007423 tetramer interface [polypeptide binding]; other site 568703007424 Uncharacterized conserved protein [Function unknown]; Region: COG3589 568703007425 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 568703007426 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 568703007427 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703007428 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 568703007429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 568703007430 DNA-binding site [nucleotide binding]; DNA binding site 568703007431 UTRA domain; Region: UTRA; cl01230 568703007432 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 568703007433 active site 568703007434 P-loop; other site 568703007435 phosphorylation site [posttranslational modification] 568703007436 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 568703007437 active site 568703007438 methionine cluster; other site 568703007439 phosphorylation site [posttranslational modification] 568703007440 metal binding site [ion binding]; metal-binding site 568703007441 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 568703007442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703007443 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 568703007444 nudix motif; other site 568703007445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703007446 Isochorismatase family; Region: Isochorismatase; pfam00857 568703007447 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 568703007448 catalytic triad [active] 568703007449 dimer interface [polypeptide binding]; other site 568703007450 conserved cis-peptide bond; other site 568703007451 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 568703007452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007453 putative substrate translocation pore; other site 568703007454 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 568703007455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 568703007456 putative substrate translocation pore; other site 568703007457 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 568703007458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 568703007459 active site 568703007460 catalytic tetrad [active] 568703007461 Domain of unknown function (DUF956); Region: DUF956; cl01917 568703007462 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 568703007463 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 568703007464 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 568703007465 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 568703007466 active pocket/dimerization site; other site 568703007467 active site 568703007468 phosphorylation site [posttranslational modification] 568703007469 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 568703007470 active site 568703007471 phosphorylation site [posttranslational modification] 568703007472 H+ Antiporter protein; Region: 2A0121; TIGR00900 568703007473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703007474 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703007475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 568703007476 C-terminal domain; Region: RGG_Cterm; TIGR01716 568703007477 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 568703007478 active site 568703007479 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703007480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703007481 substrate binding pocket [chemical binding]; other site 568703007482 membrane-bound complex binding site; other site 568703007483 hinge residues; other site 568703007484 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703007485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007486 dimer interface [polypeptide binding]; other site 568703007487 conserved gate region; other site 568703007488 putative PBP binding loops; other site 568703007489 ABC-ATPase subunit interface; other site 568703007490 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703007491 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 568703007492 Walker A/P-loop; other site 568703007493 ATP binding site [chemical binding]; other site 568703007494 Q-loop/lid; other site 568703007495 ABC transporter signature motif; other site 568703007496 Walker B; other site 568703007497 D-loop; other site 568703007498 H-loop/switch region; other site 568703007499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 568703007500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 568703007501 Protein of unknown function (DUF975); Region: DUF975; cl10504 568703007502 Bacterial membrane flanked domain; Region: DUF304; cl01348 568703007503 Predicted membrane protein [Function unknown]; Region: COG3428 568703007504 Bacterial membrane flanked domain; Region: DUF304; cl01348 568703007505 Bacterial membrane flanked domain; Region: DUF304; cl01348 568703007506 Bacterial membrane flanked domain; Region: DUF304; cl01348 568703007507 Predicted ATPase [General function prediction only]; Region: COG3910 568703007508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703007509 Walker A/P-loop; other site 568703007510 ATP binding site [chemical binding]; other site 568703007511 Q-loop/lid; other site 568703007512 ABC transporter signature motif; other site 568703007513 Walker B; other site 568703007514 D-loop; other site 568703007515 H-loop/switch region; other site 568703007516 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 568703007517 Phosphotransferase enzyme family; Region: APH; pfam01636 568703007518 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 568703007519 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 568703007520 Walker A/P-loop; other site 568703007521 ATP binding site [chemical binding]; other site 568703007522 Q-loop/lid; other site 568703007523 ABC transporter signature motif; other site 568703007524 Walker B; other site 568703007525 D-loop; other site 568703007526 H-loop/switch region; other site 568703007527 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703007528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703007529 substrate binding pocket [chemical binding]; other site 568703007530 membrane-bound complex binding site; other site 568703007531 hinge residues; other site 568703007532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007533 dimer interface [polypeptide binding]; other site 568703007534 conserved gate region; other site 568703007535 putative PBP binding loops; other site 568703007536 ABC-ATPase subunit interface; other site 568703007537 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 568703007538 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 568703007539 substrate binding pocket [chemical binding]; other site 568703007540 membrane-bound complex binding site; other site 568703007541 hinge residues; other site 568703007542 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 568703007543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 568703007544 dimer interface [polypeptide binding]; other site 568703007545 conserved gate region; other site 568703007546 putative PBP binding loops; other site 568703007547 ABC-ATPase subunit interface; other site 568703007548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 568703007549 Integral membrane protein DUF95; Region: DUF95; cl00572 568703007550 MoxR-like ATPases [General function prediction only]; Region: COG0714 568703007551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 568703007552 Walker A motif; other site 568703007553 ATP binding site [chemical binding]; other site 568703007554 Walker B motif; other site 568703007555 arginine finger; other site 568703007556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703007557 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 568703007558 Protein of unknown function DUF58; Region: DUF58; pfam01882 568703007559 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 568703007560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 568703007561 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 568703007562 putative ADP-binding pocket [chemical binding]; other site 568703007563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 568703007564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 568703007565 putative transposase OrfB; Reviewed; Region: PHA02517 568703007566 Integrase core domain; Region: rve; cl01316 568703007567 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 568703007568 Aspartase; Region: Aspartase; cd01357 568703007569 active sites [active] 568703007570 tetramer interface [polypeptide binding]; other site 568703007571 Protein of unknown function (DUF419); Region: DUF419; cl15265 568703007572 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 568703007573 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 568703007574 putative NAD(P) binding site [chemical binding]; other site 568703007575 Malic enzyme, N-terminal domain; Region: malic; pfam00390 568703007576 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 568703007577 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 568703007578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 568703007579 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 568703007580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 568703007581 active site 568703007582 phosphorylation site [posttranslational modification] 568703007583 intermolecular recognition site; other site 568703007584 dimerization interface [polypeptide binding]; other site 568703007585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007586 helicase-primase primase subunit BSLF1; Provisional; Region: PHA03142 568703007587 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 568703007588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703007589 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 568703007590 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 568703007591 catalytic triad [active] 568703007592 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 568703007593 Phage integrase family; Region: Phage_integrase; pfam00589 568703007594 Int/Topo IB signature motif; other site 568703007595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007596 non-specific DNA binding site [nucleotide binding]; other site 568703007597 salt bridge; other site 568703007598 sequence-specific DNA binding site [nucleotide binding]; other site 568703007599 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 568703007600 polymerase nucleotide-binding site; other site 568703007601 DNA-binding residues [nucleotide binding]; DNA binding site 568703007602 nucleotide binding site [chemical binding]; other site 568703007603 primase nucleotide-binding site [nucleotide binding]; other site 568703007604 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 568703007605 Virulence-associated protein E; Region: VirE; pfam05272 568703007606 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 568703007607 Phage terminase, small subunit; Region: Terminase_4; cl01525 568703007608 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 568703007609 Phage Terminase; Region: Terminase_1; pfam03354 568703007610 Phage portal protein; Region: Phage_portal; pfam04860 568703007611 Phage-related protein [Function unknown]; Region: COG4695; cl01923 568703007612 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 568703007613 Phage capsid family; Region: Phage_capsid; pfam05065 568703007614 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 568703007615 oligomerization interface [polypeptide binding]; other site 568703007616 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 568703007617 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 568703007618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703007619 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 568703007620 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 568703007621 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 568703007622 substrate binding pocket [chemical binding]; other site 568703007623 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 568703007624 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 568703007625 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 568703007626 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 568703007627 active site 568703007628 phosphorylation site [posttranslational modification] 568703007629 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 568703007630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 568703007631 PRD domain; Region: PRD; pfam00874 568703007632 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 568703007633 P-loop; other site 568703007634 active site 568703007635 phosphorylation site [posttranslational modification] 568703007636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 568703007637 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 568703007638 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 568703007639 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 568703007640 active site 568703007641 P-loop; other site 568703007642 phosphorylation site [posttranslational modification] 568703007643 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 568703007644 active site 568703007645 P-loop; other site 568703007646 phosphorylation site [posttranslational modification] 568703007647 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 568703007648 active site 568703007649 trimer interface [polypeptide binding]; other site 568703007650 allosteric site; other site 568703007651 active site lid [active] 568703007652 hexamer (dimer of trimers) interface [polypeptide binding]; other site 568703007653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 568703007654 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 568703007655 active site 568703007656 motif I; other site 568703007657 motif II; other site 568703007658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 568703007659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 568703007660 non-specific DNA binding site [nucleotide binding]; other site 568703007661 salt bridge; other site 568703007662 sequence-specific DNA binding site [nucleotide binding]; other site 568703007663 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703007664 Domain of unknown function (DUF955); Region: DUF955; cl01076 568703007665 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 568703007666 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 568703007667 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 568703007668 Walker A/P-loop; other site 568703007669 ATP binding site [chemical binding]; other site 568703007670 Q-loop/lid; other site 568703007671 ABC transporter signature motif; other site 568703007672 Walker B; other site 568703007673 D-loop; other site 568703007674 H-loop/switch region; other site 568703007675 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 568703007676 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 568703007677 FtsX-like permease family; Region: FtsX; pfam02687 568703007678 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 568703007679 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 568703007680 aspartate aminotransferase; Provisional; Region: PRK07681 568703007681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 568703007682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 568703007683 homodimer interface [polypeptide binding]; other site 568703007684 catalytic residue [active] 568703007685 Predicted amidohydrolase [General function prediction only]; Region: COG0388 568703007686 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 568703007687 putative active site [active] 568703007688 catalytic triad [active] 568703007689 putative dimer interface [polypeptide binding]; other site 568703007690 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 568703007691 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 568703007692 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 568703007693 putative active site [active] 568703007694 metal binding site [ion binding]; metal-binding site 568703007695 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 568703007696 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 568703007697 metal binding site [ion binding]; metal-binding site 568703007698 dimer interface [polypeptide binding]; other site 568703007699 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703007700 Uncharacterized conserved protein [Function unknown]; Region: COG2966 568703007701 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 568703007702 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 568703007703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 568703007704 Walker A/P-loop; other site 568703007705 ATP binding site [chemical binding]; other site 568703007706 Q-loop/lid; other site 568703007707 ABC transporter signature motif; other site 568703007708 Walker B; other site 568703007709 D-loop; other site 568703007710 H-loop/switch region; other site 568703007711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 568703007712 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 568703007713 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 568703007714 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 568703007715 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 568703007716 G1 box; other site 568703007717 GTP/Mg2+ binding site [chemical binding]; other site 568703007718 Switch I region; other site 568703007719 G2 box; other site 568703007720 Switch II region; other site 568703007721 G3 box; other site 568703007722 G4 box; other site 568703007723 G5 box; other site 568703007724 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 568703007725 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 568703007726 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 568703007727 G-X-X-G motif; other site 568703007728 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 568703007729 RxxxH motif; other site 568703007730 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 568703007731 Ribonuclease P; Region: Ribonuclease_P; cl00457 568703007732 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 568703007733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415