-- dump date 20120504_151251 -- class Genbank::CDS -- table cds_note -- id note YP_163738.1 ORF1 YP_163739.1 ORF2 YP_163740.1 ORF3 YP_163741.1 ORF4 YP_163742.1 ORF5 YP_163743.1 RepA YP_163744.1 ORF7 YP_163745.1 ORF8 YP_163746.1 ORF9 YP_163747.1 ORF10 YP_163748.1 ORF11 YP_163749.1 ORF12 YP_163750.1 ORF13 YP_163751.1 Gls14; similar to Gls24 from Enterococcus faecalis YP_163752.1 Gls15; similar to GlsB from Enterococcus faecalis YP_163753.1 ORF16 YP_163754.1 ORF17 YP_163755.1 ORF18 YP_163756.1 ORF19 YP_163757.1 ORF20 YP_163758.1 ORF21 YP_163759.1 ORF22 YP_163760.1 ORF23 YP_163761.1 ORF24 YP_163762.1 ORF25; probable suppressor of the inhibitory function of PemK YP_163763.1 ORF26; probable growth inhibitor YP_163764.1 ORF27 YP_163765.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_163778.1 RepA YP_163804.1 ABC transporter permease and substrate binding protein YP_163805.1 ATP-binding protein YP_163810.1 similar to Escherichia coli DinJ damage inducible protein YP_534907.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_534908.1 COG0592 [L] DNA polymerase sliding clamp subunit (PCNA homolog) YP_534909.1 COG0011 [S] Uncharacterized conserved protein YP_534910.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_534911.1 COG0187 [L] type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit YP_534912.1 COG0188 [L] type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit YP_534913.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_534914.1 COG0629 [L] Single-stranded DNA-binding protein YP_534915.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_534916.1 COG2084 [I] 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases YP_534917.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_534918.1 COG0367 [E] Asparagine synthase (glutamine-hydrolyzing) YP_534919.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_534920.1 COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_534922.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_534923.1 COG3919 [R] Predicted ATP-grasp enzyme YP_534924.1 COG1794 [M] Aspartate racemase YP_534925.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_534926.1 COG0583 [K] Transcriptional regulator YP_534927.1 COG4975 [G] glucose uptake permease YP_534928.1 COG0011 [S] Uncharacterized conserved protein YP_534930.1 COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_534931.1 COG1164 [E] Oligoendopeptidase F YP_534932.1 COG0031 [E] Cysteine synthase YP_534933.1 COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases YP_534934.1 COG0371 [C] Glycerol dehydrogenase and related enzymes YP_534935.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_534937.1 COG0583 [K] Transcriptional regulator YP_534938.1 COG1132 [V] ABC-type multidrug transport system, ATPase and permease components YP_534939.1 COG1132 [V] ABC-type multidrug transport system, ATPase and permease components YP_534940.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_534941.1 COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_534942.1 COG0642 [T] signal transduction histidine kinase YP_534943.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_534944.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_534945.1 COG1235 [R] Metal-dependent hydrolases of the beta-lactamase superfamily I YP_534946.1 COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_534947.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_534948.1 COG0702 [MG] Predicted nucleoside-diphosphate-sugar epimerases YP_534949.1 COG1522 [K] Transcriptional regulators YP_534950.1 COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_534952.1 COG2271 [G] Sugar phosphate permease YP_534953.1 COG0675 [L] Transposase and inactivated derivatives YP_534954.1 COG0675 [L] Transposase and inactivated derivatives YP_534956.1 COG0534 [V] Na+-driven multidrug efflux pump YP_534957.1 COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_534959.1 COG0652 [O] Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_534960.1 COG2071 [R] Predicted glutamine amidotransferases YP_534961.1 COG2918 [H] Gamma-glutamylcysteine synthetase YP_534963.1 COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_534964.1 COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_534966.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_534967.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_534968.1 COG1522 [K] Transcriptional regulators YP_534969.1 COG1621 [G] beta-fructosidases (levanase/invertase) YP_534970.1 COG1263 [G] Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_534971.1 COG0366 [G] Glycosidases YP_534972.1 COG0168 [P] Trk-type K+ transport systems, membrane components YP_534973.1 COG0569 [P] K+ transport systems, NAD-binding component YP_534974.1 COG2738 [R] Predicted Zn-dependent protease YP_534975.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_534977.1 COG0344 [S] Predicted membrane protein YP_534978.1 COG0011 [S] Uncharacterized conserved protein YP_534979.1 COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_534980.1 COG1349 [KG] Transcriptional regulators of sugar metabolism YP_534982.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_534983.1 COG0583 [K] Transcriptional regulator YP_534984.1 COG0346 [E] Lactoylglutathione lyase and related lyases YP_534985.1 COG1811 [R] Uncharacterized membrane protein, possible Na+ channel or pump YP_534986.1 COG1653 [G] ABC-type sugar transport system, periplasmic component YP_534987.1 COG2197 [TK] Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_534988.1 COG0642 [T] signal transduction histidine kinase YP_534989.1 COG1653 [G] ABC-type sugar transport system, periplasmic component YP_534990.1 COG2893 [G] Phosphotransferase system, mannose/fructose-specific component IIA YP_534991.1 COG3715 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC YP_534992.1 COG3716 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID YP_534993.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_534994.1 COG1388 [M] FOG: LysM repeat YP_534995.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_534996.1 COG0111 [HE] Phosphoglycerate dehydrogenase and related dehydrogenases YP_534997.1 COG1573 [L] Uracil-DNA glycosylase YP_534999.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535002.1 COG1343 [L] Uncharacterized protein predicted to be involved in DNA repair YP_535003.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535005.1 COG0640 [K] Predicted transcriptional regulators YP_535006.1 COG0344 [S] Predicted membrane protein YP_535008.1 COG0583 [K] Transcriptional regulator YP_535010.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_535011.1 COG0240 [C] Glycerol-3-phosphate dehydrogenase YP_535012.1 COG0580 [G] Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_535013.1 COG3842 [E] ABC-type spermidine/putrescine transport systems, ATPase components YP_535014.1 COG1176 [E] ABC-type spermidine/putrescine transport system, permease component I YP_535015.1 COG1177 [E] ABC-type spermidine/putrescine transport system, permease component II YP_535016.1 COG0687 [E] Spermidine/putrescine-binding periplasmic protein YP_535017.1 COG2984 [R] ABC-type uncharacterized transport system, periplasmic component YP_535018.1 COG0390 [R] ABC-type uncharacterized transport system, permease component YP_535019.1 COG1101 [R] ABC-type uncharacterized transport system, ATPase component YP_535020.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535021.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_535023.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_535024.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_535025.1 COG0406 [G] Fructose-2,6-bisphosphatase YP_535026.1 COG1266 [R] Predicted metal-dependent membrane protease YP_535027.1 COG0716 [C] Flavodoxins YP_535028.1 COG1791 [S] Uncharacterized conserved protein, contains double-stranded beta-helix domain YP_535029.1 COG0620 [E] Methionine synthase II (cobalamin-independent) YP_535030.1 COG1464 [P] ABC-type metal ion transport system, periplasmic component/surface antigen YP_535031.1 COG1135 [P] ABC-type metal ion transport system, ATPase component YP_535032.1 COG2011 [P] ABC-type metal ion transport system, permease component YP_535033.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_535034.1 COG0778 [C] Nitroreductase YP_535036.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_535037.1 COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_535038.1 COG1982 [E] Arginine/lysine/ornithine decarboxylases YP_535040.1 COG2011 [P] ABC-type metal ion transport system, permease component YP_535041.1 COG1464 [P] ABC-type metal ion transport system, periplasmic component/surface antigen YP_535044.1 Converts glucose to D-glucono-1,5 lactone YP_535045.1 COG4975 [G] glucose uptake permease YP_535046.1 COG0583 [K] Transcriptional regulator YP_535047.1 COG0656 [R] Aldo/keto reductases, related to diketogulonate reductase YP_535048.1 COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_535051.1 COG1071 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit YP_535052.1 COG0022 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit YP_535053.1 COG0508 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes YP_535054.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_535055.1 COG0095 [H] Lipoate-protein ligase A YP_535056.1 COG0392 [S] Predicted integral membrane protein YP_535059.1 ACT domain-containing protein YP_535060.1 COG0011 [S] Uncharacterized conserved protein YP_535061.1 COG1349 [KG] Transcriptional regulators of sugar metabolism YP_535062.1 COG1105 [G] Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) YP_535063.1 COG1299 [G] Phosphotransferase system, fructose-specific IIC component YP_535066.1 COG0531 [E] Amino acid transporters YP_535067.1 COG0474 [P] Cation transport ATPase YP_535068.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535069.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_535070.1 COG0518 [F] GMP synthase - Glutamine amidotransferase domain; glutamine-hydrolyzing YP_535071.1 COG2050 [Q] Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_535072.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_535073.1 converts O-succinylbenzoate to O-succinylbenzoyl-CoA YP_535074.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535075.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_535076.1 COG0583 [K] Transcriptional regulator YP_535077.1 COG4690 [E] Dipeptidase YP_535078.1 COG0583 [K] Transcriptional regulator YP_535079.1 COG0344 [S] Predicted membrane protein YP_535080.1 COG0679 [R] Predicted permeases YP_535081.1 COG0583 [K] Transcriptional regulator YP_535082.1 COG0671 [I] Membrane-associated phospholipid phosphatase YP_535084.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_535085.1 COG3527 [Q] alpha-acetolactate decarboxylase YP_535086.1 COG0531 [E] Amino acid transporters YP_535087.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_535088.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_535089.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_535090.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_535091.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_535092.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_535093.1 COG4463 [K] Transcriptional repressor of class III stress genes YP_535094.1 COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_535095.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_535096.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_535097.1 COG1989 [NOU] type II secretory pathway, prepilin signal peptidase PulO and related peptidases YP_535098.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_535099.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_535100.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_535101.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_535102.1 COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities YP_535103.1 COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_535104.1 COG0642 [T] signal transduction histidine kinase YP_535105.1 COG2017 [G] Galactose mutarotase and related enzymes YP_535106.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_535107.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_535108.1 COG1136 [V] ABC-type antimicrobial peptide transport system, ATPase component YP_535109.1 COG0583 [K] Transcriptional regulator YP_535110.1 COG1132 [V] ABC-type multidrug transport system, ATPase and permease components YP_535111.1 COG2110 [R] Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 YP_535112.1 COG0011 [S] Uncharacterized conserved protein YP_535113.1 metalloprotease YP_535114.1 COG0210 [L] Superfamily I DNA and RNA helicases YP_535115.1 COG0053 [P] Predicted Co/Zn/Cd cation transporters YP_535116.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_535117.1 COG0248 [FP] Exopolyphosphatase YP_535118.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_535119.1 COG0842 [V] ABC-type multidrug transport system, permease component YP_535120.1 COG0583 [K] Transcriptional regulator YP_535121.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_535122.1 COG1257 [I] Hydroxymethylglutaryl-CoA reductase YP_535124.1 COG0143 [J] Methionyl-tRNA synthetase YP_535125.1 COG0084 [L] Mg-dependent DNase YP_535126.1 COG1658 [L] Small primase-like proteins (Toprim domain) YP_535127.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_535128.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535129.1 COG4814 [R] Uncharacterized protein with an alpha/beta hydrolase fold YP_535130.1 associated with arginine deiminase pathway genes; probably functions in arginine catabolism YP_535131.1 COG1438 [K] Arginine repressor YP_535132.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_535133.1 COG0004 [P] Ammonia permease YP_535134.1 COG0582 [L] Integrase YP_535138.1 COG0455 [D] ATPases involved in chromosome partitioning YP_535140.1 COG0640 [K] Predicted transcriptional regulators YP_535148.1 COG0640 [K] Predicted transcriptional regulators YP_535149.1 COG3645 [S] Uncharacterized phage-encoded protein YP_535176.1 COG1403 [V] Restriction endonuclease YP_535177.1 COG3728 [L] phage terminase, small subunit YP_535178.1 COG4626 [R] phage terminase-like protein, large subunit YP_535180.1 COG4672 [S] phage-related protein YP_535181.1 COG0740 [OU] Protease subunit of ATP-dependent Clp proteases YP_535191.1 COG5283 [S] phage-related tail protein YP_535193.1 COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_535201.1 COG1388 [M] FOG: LysM repeat YP_535202.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_535203.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_535204.1 COG0436 [E] Aspartate/tyrosine/aromatic aminotransferase YP_535205.1 COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases YP_535206.1 COG3641 [R] Predicted membrane protein, toxin regulator YP_535207.1 COG3652 [S] Predicted outer membrane protein YP_535208.1 COG0675 [L] Transposase and inactivated derivatives YP_535209.1 catalyzes the formation of aspartate semialdehyde from aspartyl phosphate YP_535210.1 COG0640 [K] Predicted transcriptional regulators YP_535211.1 COG0503 [F] Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins YP_535212.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_535213.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_535214.1 COG0462 [FE] Phosphoribosylpyrophosphate synthetase YP_535215.1 COG1670 [J] acetyltransferases, including N-acetylases of ribosomal proteins YP_535216.1 COG0656 [R] Aldo/keto reductases, related to diketogulonate reductase YP_535218.1 COG2820 [F] Uridine phosphorylase YP_535219.1 COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_535220.1 COG2220 [R] Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_535221.1 COG0340 [H] Biotin-(acetyl-CoA carboxylase) ligase YP_535222.1 COG5438 [S] Predicted multitransmembrane protein YP_535223.1 COG5438 [S] Predicted multitransmembrane protein YP_535225.1 COG0464 [O] ATPases of the AAA+ class YP_535232.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535233.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_535234.1 COG1078 [R] HD superfamily phosphohydrolases YP_535235.1 COG0518 [F] GMP synthase - Glutamine amidotransferase domain; glutamine-hydrolyzing YP_535237.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_535238.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_535241.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_535242.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_535243.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_535245.1 COG1199 [KL] Rad3-related DNA helicases YP_535249.1 COG2252 [R] Permeases YP_535250.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535251.1 COG0770 [M] UDP-N-acetylmuramyl pentapeptide synthase YP_535252.1 COG0513 [LKJ] Superfamily II DNA and RNA helicases YP_535253.1 COG0736 [I] Phosphopantetheinyl transferase (holo-ACP synthase) YP_535254.1 COG0787 [M] Alanine racemase YP_535256.1 COG2337 [T] Growth inhibitor YP_535257.1 COG0011 [S] Uncharacterized conserved protein YP_535258.1 COG2404 [R] Predicted phosphohydrolase (DHH superfamily) YP_535259.1 COG0242 [J] N-formylmethionyl-tRNA deformylase YP_535261.1 COG1597 [IR] Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_535262.1 COG4892 [R] Predicted heme/steroid binding protein YP_535264.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_535265.1 COG2265 [J] SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_535266.1 COG3557 [J] Uncharacterized domain/protein associated with RNAses G and E YP_535267.1 COG0628 [R] Predicted permease YP_535268.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_535269.1 COG1134 [GM] ABC-type polysaccharide/polyol phosphate transport system, ATPase component YP_535270.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_535272.1 COG3250 [G] beta-galactosidase/beta-glucuronidase YP_535273.1 COG1522 [K] Transcriptional regulators YP_535274.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_535275.1 COG1087 [M] UDP-glucose 4-epimerase YP_535276.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_535279.1 COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_535281.1 COG1925 [G] Phosphotransferase system, HPr-related proteins YP_535282.1 COG1080 [G] Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) YP_535283.1 COG0438 [M] Glycosyltransferase YP_535284.1 COG0438 [M] Glycosyltransferase YP_535285.1 COG0392 [S] Predicted integral membrane protein YP_535286.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535287.1 COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_535288.1 COG1866 [C] Phosphoenolpyruvate carboxykinase (ATP) YP_535289.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_535290.1 COG4469 [R] Competence protein YP_535291.1 COG1164 [E] Oligoendopeptidase F YP_535292.1 COG2761 [Q] Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis YP_535293.1 COG0226 [P] ABC-type phosphate transport system, periplasmic component YP_535294.1 COG0573 [P] ABC-type phosphate transport system, permease component YP_535295.1 COG0573 [P] ABC-type phosphate transport system, permease component YP_535296.1 COG1117 [P] ABC-type phosphate transport system, ATPase component YP_535297.1 COG1117 [P] ABC-type phosphate transport system, ATPase component YP_535298.1 COG0704 [P] Phosphate uptake regulator YP_535299.1 COG0191 [G] Fructose/tagatose bisphosphate aldolase YP_535300.1 COG0675 [L] Transposase and inactivated derivatives YP_535302.1 COG0700 [S] Uncharacterized membrane protein YP_535303.1 COG0700 [S] Uncharacterized membrane protein YP_535305.1 COG1272 [R] Predicted membrane protein, hemolysin III homolog YP_535306.1 COG0583 [K] Transcriptional regulator YP_535307.1 COG0675 [L] Transposase and inactivated derivatives YP_535308.1 COG0328 [L] Ribonuclease HI YP_535310.1 COG4768 [R] Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain YP_535312.1 COG0006 [E] Xaa-Pro aminopeptidase YP_535313.1 COG1522 [K] Transcriptional regulators YP_535315.1 COG0011 [S] Uncharacterized conserved protein YP_535316.1 COG0524 [G] Sugar kinases, ribokinase family YP_535317.1 COG2804 [NU] type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB YP_535318.1 COG1459 [NU] type II secretory pathway, component PulF YP_535325.1 COG0827 [L] Adenine-specific DNA methylase YP_535326.1 COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_535327.1 COG4186 [R] Predicted phosphoesterase or phosphohydrolase YP_535328.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535329.1 COG0647 [G] Predicted sugar phosphatases of the HAD superfamily YP_535330.1 COG0344 [S] Predicted membrane protein YP_535331.1 COG0586 [S] Uncharacterized membrane-associated protein YP_535332.1 COG0492 [O] Thioredoxin reductase YP_535333.1 COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain) YP_535334.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_535335.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_535336.1 COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_535337.1 COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_535338.1 COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_535339.1 COG0061 [G] Predicted sugar kinase YP_535340.1 COG0624 [E] acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases YP_535342.1 COG0764 [I] 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases YP_535343.1 COG1522 [K] Transcriptional regulators YP_535344.1 COG0332 [I] 3-oxoacyl-[acyl-carrier-protein] synthase III YP_535345.1 COG0236 [IQ] acyl carrier protein YP_535346.1 COG0331 [I] (acyl-carrier-protein) S-malonyltransferase YP_535347.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_535348.1 COG0304 [IQ] 3-oxoacyl-(acyl-carrier-protein) synthase YP_535349.1 COG0511 [I] Biotin carboxyl carrier protein YP_535350.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_535351.1 COG0439 [I] Biotin carboxylase YP_535352.1 COG0777 [I] acetyl-CoA carboxylase beta subunit YP_535353.1 COG0825 [I] acetyl-CoA carboxylase alpha subunit YP_535354.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_535355.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_535356.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_535357.1 COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_535358.1 COG0580 [G] Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_535359.1 COG0517 [R] FOG: CBS domain YP_535360.1 COG2171 [E] Tetrahydrodipicolinate N-succinyltransferase YP_535361.1 COG1473 [R] Metal-dependent amidase/aminoacylase/carboxypeptidase YP_535362.1 COG0668 [M] Small-conductance mechanosensitive channel YP_535363.1 COG0583 [K] Transcriptional regulator YP_535364.1 COG0744 [M] Membrane carboxypeptidase (penicillin-binding protein) YP_535365.1 COG0011 [S] Uncharacterized conserved protein YP_535366.1 COG3481 [R] Predicted HD-superfamily hydrolase YP_535367.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein YP_535369.1 COG0537 [FGR] Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_535370.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_535371.1 COG4473 [U] Predicted ABC-type exoprotein transport system, permease component YP_535372.1 COG0510 [M] Predicted choline kinase involved in LPS biosynthesis YP_535373.1 COG0220 [R] Predicted S-adenosylmethionine-dependent methyltransferase YP_535375.1 COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_535376.1 COG0073 [R] EMAP domain YP_535377.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_535378.1 COG2030 [I] acyl dehydratase YP_535379.1 COG0670 [R] Integral membrane protein, interacts with FtsH YP_535380.1 COG0749 [L] DNA polymerase I - 3'-5' exonuclease and polymerase domains YP_535381.1 COG0266 [L] Formamidopyrimidine-DNA glycosylase YP_535382.1 COG0237 [H] Dephospho-CoA kinase YP_535383.1 COG1327 [K] Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_535384.1 COG3611 [L] Replication initiation/membrane attachment protein YP_535385.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_535386.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_535387.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_535388.1 COG0291 [J] Ribosomal protein L35 YP_535389.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_535390.1 COG0675 [L] Transposase and inactivated derivatives YP_535391.1 COG2179 [R] Predicted hydrolase of the HAD superfamily YP_535392.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_535393.1 COG1534 [J] Predicted RNA-binding protein containing KH domain, possibly ribosomal protein YP_535394.1 COG1057 [H] Nicotinic acid mononucleotide adenylyltransferase YP_535395.1 COG1713 [H] Predicted HD superfamily hydrolase involved in NAD metabolism YP_535396.1 COG0799 [S] Uncharacterized homolog of plant Iojap protein YP_535397.1 COG1019 [R] Predicted nucleotidyltransferase YP_535398.1 COG1399 [R] Predicted metal-binding, possibly nucleic acid-binding protein YP_535399.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_535400.1 COG0204 [I] 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_535401.1 COG4122 [R] Predicted O-methyltransferase YP_535402.1 COG2827 [L] Predicted endonuclease containing a URI domain YP_535403.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_535404.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_535406.1 COG1428 [F] Deoxynucleoside kinases YP_535407.1 COG0041 [F] Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_535408.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_535409.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_535410.1 COG3049 [M] Penicillin V acylase and related amidases YP_535414.1 COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_535415.1 COG0642 [T] signal transduction histidine kinase YP_535416.1 COG0706 [U] Preprotein translocase subunit YidC YP_535417.1 COG1254 [C] acylphosphatases YP_535418.1 COG3425 [I] 3-hydroxy-3-methylglutaryl CoA synthase YP_535422.1 COG0231 [J] Translation elongation factor P (EF-P); translation initiation factor 5A (eIF-5A) YP_535423.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535424.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_535425.1 COG0190 [H] 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase YP_535426.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_535427.1 COG1722 [L] Exonuclease VII small subunit YP_535428.1 COG0142 [H] Geranylgeranyl pyrophosphate synthase YP_535429.1 COG1189 [J] Predicted rRNA methylase YP_535430.1 COG1438 [K] Arginine repressor YP_535431.1 COG0419 [L] ATPase involved in DNA repair YP_535432.1 COG1974 [KT] SOS-response transcriptional repressors (RecA-mediated autopeptidases) YP_535433.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535434.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535435.1 COG0218 [R] Predicted GTPase YP_535436.1 COG1694 [R] Predicted pyrophosphatase YP_535438.1 COG0675 [L] Transposase and inactivated derivatives YP_535439.1 COG0419 [L] ATPase involved in DNA repair YP_535440.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_535441.1 COG0212 [H] 5-formyltetrahydrofolate cyclo-ligase YP_535442.1 COG0705 [R] Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_535443.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535444.1 COG1940 [KG] Transcriptional regulator/sugar kinase YP_535445.1 COG0607 [P] Rhodanese-related sulfurtransferase YP_535447.1 COG0324 [J] tRNA delta(2)-isopentenylpyrophosphate transferase YP_535448.1 COG4100 [P] Cystathionine beta-lyase family protein involved in aluminum resistance YP_535449.1 COG0640 [K] Predicted transcriptional regulators YP_535450.1 COG0174 [E] Glutamine synthetase YP_535451.1 COG0350 [L] Methylated DNA-protein cysteine methyltransferase YP_535452.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535453.1 COG0528 [F] Uridylate kinase YP_535454.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_535455.1 COG0020 [I] Undecaprenyl pyrophosphate synthase YP_535456.1 COG0575 [I] CDP-diglyceride synthetase YP_535457.1 COG0750 [M] Predicted membrane-associated Zn-dependent proteases 1 YP_535458.1 COG0442 [J] Prolyl-tRNA synthetase YP_535459.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_535460.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_535461.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_535462.1 COG2740 [K] Predicted nucleic-acid-binding protein implicated in transcription termination YP_535463.1 COG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a) YP_535464.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_535465.1 COG0858 [J] Ribosome-binding factor A YP_535466.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_535467.1 COG0196 [H] FAD synthase YP_535468.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_535469.1 COG0576 [O] Molecular chaperone GrpE (heat shock protein) YP_535470.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_535471.1 COG0484 [O] DnaJ-class molecular chaperone with C-terminal Zn finger domain YP_535472.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_535473.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_535474.1 COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_535476.1 COG1680 [V] beta-lactamase class C and other penicillin binding proteins YP_535477.1 COG0675 [L] Transposase and inactivated derivatives YP_535478.1 COG0675 [L] Transposase and inactivated derivatives YP_535479.1 COG0121 [R] Predicted glutamine amidotransferase YP_535480.1 COG0769 [M] UDP-N-acetylmuramyl tripeptide synthase YP_535481.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_535482.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_535483.1 COG2890 [J] Methylase of polypeptide chain release factors YP_535484.1 COG0009 [J] translation factor (SUA5) YP_535485.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_535486.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_535487.1 COG0636 [C] F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K YP_535488.1 COG0711 [C] F0F1-type ATP synthase, subunit b YP_535489.1 COG0712 [C] F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) YP_535490.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_535491.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_535492.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_535493.1 COG0355 [C] F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) YP_535495.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_535496.1 COG1077 [D] Actin-like ATPase involved in cell morphogenesis YP_535497.1 COG0011 [S] Uncharacterized conserved protein YP_535499.1 COG0772 [D] Bacterial cell division membrane protein YP_535500.1 COG1393 [P] Arsenate reductase and related proteins, glutaredoxin family YP_535501.1 COG0675 [L] Transposase and inactivated derivatives YP_535503.1 Essential for recycling GMP and indirectly, cGMP YP_535505.1 COG0452 [H] Phosphopantothenoylcysteine synthetase/decarboxylase YP_535507.1 COG0223 [J] Methionyl-tRNA formyltransferase YP_535508.1 COG0144 [J] tRNA and rRNA cytosine-C5-methylases YP_535509.1 COG0631 [T] Serine/threonine protein phosphatase YP_535510.1 COG1160 [R] Predicted GTPases YP_535511.1 COG1564 [H] Thiamine pyrophosphokinase YP_535512.1 required for 70S ribosome assembly YP_535513.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535514.1 COG1461 [R] Predicted kinase related to dihydroxyacetone kinase YP_535515.1 COG1200 [LK] RecG-like helicase YP_535516.1 COG0416 [I] Fatty acid/phospholipid biosynthesis enzyme YP_535517.1 COG0236 [IQ] acyl carrier protein YP_535518.1 COG0571 [K] dsRNA-specific ribonuclease YP_535519.1 COG1196 [D] Chromosome segregation ATPases YP_535520.1 COG0541 [U] signal recognition particle GTPase YP_535521.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535522.1 COG0541 [U] signal recognition particle GTPase YP_535523.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_535524.1 COG1837 [R] Predicted RNA-binding protein (contains KH domain) YP_535525.1 COG0806 [J] RimM protein, required for 16S rRNA processing YP_535526.1 COG0336 [J] tRNA-(guanine-N1)-methyltransferase YP_535527.1 COG1247 [M] Sortase and related acyltransferases YP_535528.1 COG0531 [E] Amino acid transporters YP_535529.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_535530.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_535531.1 COG0184 [J] Ribosomal protein S15P/S13E YP_535532.1 COG0329 [EM] Dihydrodipicolinate synthase/N-acetylneuraminate lyase YP_535533.1 COG0595 [R] Predicted hydrolase of the metallo-beta-lactamase superfamily YP_535535.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_535536.1 COG0544 [O] FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) YP_535537.1 binds and unfolds substrates as part of the ClpXP protease YP_535538.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_535539.1 COG0595 [R] Predicted hydrolase of the metallo-beta-lactamase superfamily YP_535540.1 COG5428 [S] Uncharacterized conserved small protein YP_535542.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_535544.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535545.1 COG0483 [G] Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family YP_535546.1 COG1217 [T] Predicted membrane GTPase involved in stress response YP_535547.1 COG2893 [G] Phosphotransferase system, mannose/fructose-specific component IIA YP_535548.1 COG3715 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC YP_535549.1 COG3716 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID YP_535550.1 COG0772 [D] Bacterial cell division membrane protein YP_535551.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_535552.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535553.1 COG0742 [L] N6-adenine-specific methylase YP_535554.1 COG0669 [H] Phosphopantetheine adenylyltransferase YP_535555.1 COG3480 [T] Predicted secreted protein containing a PDZ domain YP_535556.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_535557.1 COG1828 [F] Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component YP_535558.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_535559.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_535560.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_535561.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_535562.1 COG0299 [F] Folate-dependent phosphoribosylglycinamide formyltransferase PurN YP_535563.1 involved in de novo purine biosynthesis YP_535564.1 COG0151 [F] Phosphoribosylamine-glycine ligase YP_535566.1 COG1502 [I] Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes YP_535567.1 COG0583 [K] Transcriptional regulator YP_535569.1 COG1011 [R] Predicted hydrolase (HAD superfamily) YP_535570.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_535571.1 COG1555 [L] DNA uptake protein and related DNA-binding proteins YP_535572.1 COG2131 [F] Deoxycytidylate deaminase YP_535573.1 COG2248 [R] Predicted hydrolase (metallo-beta-lactamase superfamily) YP_535574.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_535575.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_535576.1 COG1577 [I] Mevalonate kinase YP_535577.1 COG3407 [I] Mevalonate pyrophosphate decarboxylase YP_535578.1 COG1577 [I] Mevalonate kinase YP_535579.1 COG1199 [KL] Rad3-related DNA helicases YP_535580.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535581.1 COG0436 [E] Aspartate/tyrosine/aromatic aminotransferase YP_535582.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_535583.1 COG3935 [L] primosome component and related proteins YP_535584.1 COG0177 [L] Predicted EndoIII-related endonuclease YP_535585.1 COG0225 [O] Peptide methionine sulfoxide reductase YP_535586.1 COG0011 [S] Uncharacterized conserved protein YP_535588.1 COG3774 [M] Mannosyltransferase OCH1 and related enzymes YP_535589.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_535592.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535593.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_535594.1 COG0011 [S] Uncharacterized conserved protein YP_535597.1 COG0011 [S] Uncharacterized conserved protein YP_535598.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_535599.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_535600.1 COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_535601.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_535602.1 COG0262 [H] Dihydrofolate reductase YP_535603.1 COG0656 [R] Aldo/keto reductases, related to diketogulonate reductase YP_535604.1 COG0640 [K] Predicted transcriptional regulators YP_535605.1 COG3573 [R] Predicted oxidoreductase YP_535607.1 COG2755 [E] Lysophospholipase L1 and related esterases YP_535608.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535609.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535610.1 COG1160 [R] Predicted GTPases YP_535611.1 COG0164 [L] Ribonuclease HII YP_535612.1 COG0758 [LU] Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_535613.1 COG0550 [L] Topoisomerase IA YP_535614.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_535615.1 COG3775 [G] Phosphotransferase system, galactitol-specific IIC component YP_535616.1 COG0583 [K] Transcriptional regulator YP_535617.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_535618.1 COG3559 [M] exporter of polyketide antibiotics YP_535619.1 COG0406 [G] Fructose-2,6-bisphosphatase YP_535620.1 COG0457 [R] FOG: TPR repeat YP_535621.1 COG0507 [L] ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_535622.1 COG0582 [L] Integrase YP_535625.1 COG0675 [L] Transposase and inactivated derivatives YP_535626.1 COG0675 [L] Transposase and inactivated derivatives YP_535634.1 COG2856 [E] Predicted Zn peptidase YP_535635.1 COG0640 [K] Predicted transcriptional regulators YP_535645.1 COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family YP_535653.1 COG0433 [R] Predicted ATPase YP_535658.1 COG0582 [L] Integrase YP_535660.1 COG0286 [V] type I restriction-modification system methyltransferase subunit YP_535674.1 COG1403 [V] Restriction endonuclease YP_535675.1 COG3728 [L] phage terminase, small subunit YP_535676.1 COG4626 [R] phage terminase-like protein, large subunit YP_535677.1 COG4672 [S] phage-related protein YP_535678.1 COG0740 [OU] Protease subunit of ATP-dependent Clp proteases YP_535687.1 COG5283 [S] phage-related tail protein YP_535690.1 COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_535698.1 COG1388 [M] FOG: LysM repeat YP_535703.1 COG0566 [J] rRNA methylases YP_535704.1 COG1418 [R] Predicted HD superfamily hydrolase YP_535705.1 COG0640 [K] Predicted transcriptional regulators YP_535706.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_535707.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_535708.1 COG1427 [R] Predicted periplasmic solute-binding protein YP_535709.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_535710.1 COG0195 [K] Transcription elongation factor YP_535712.1 COG1957 [F] Inosine-uridine nucleoside N-ribohydrolase YP_535714.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535715.1 COG0317 [TK] Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_535716.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_535717.1 COG0546 [R] Predicted phosphatases YP_535718.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_535719.1 COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_535720.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_535721.1 COG2233 [F] Xanthine/uracil permeases YP_535722.1 COG0505 [EF] Carbamoylphosphate synthase small subunit YP_535723.1 COG0284 [F] Orotidine-5'-phosphate decarboxylase YP_535724.1 COG0461 [F] Orotate phosphoribosyltransferase YP_535725.1 COG0583 [K] Transcriptional regulator YP_535726.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_535727.1 COG1349 [KG] Transcriptional regulators of sugar metabolism YP_535728.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci YP_535729.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_535731.1 GpsB; guiding PBP1 shuttling; similar to DivIVA YP_535732.1 COG0116 [L] Predicted N6-adenine-specific DNA methylase YP_535735.1 COG2759 [F] Formyltetrahydrofolate synthetase YP_535737.1 COG1196 [D] Chromosome segregation ATPases YP_535739.1 COG2384 [R] Predicted SAM-dependent methyltransferase YP_535740.1 COG0011 [S] Uncharacterized conserved protein YP_535741.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_535742.1 COG4912 [L] Predicted DNA alkylation repair enzyme YP_535743.1 COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_535744.1 COG0457 [R] FOG: TPR repeat YP_535745.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_535746.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_535747.1 COG0598 [P] Mg2+ and Co2+ transporters YP_535748.1 COG1757 [C] Na+/H+ antiporter YP_535749.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_535750.1 COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_535752.1 COG0775 [F] Nucleoside phosphorylase YP_535753.1 COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_535755.1 COG0482 [J] Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain YP_535756.1 COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_535758.1 COG0587 [L] DNA polymerase III, alpha subunit YP_535759.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_535760.1 COG0469 [G] Pyruvate kinase YP_535762.1 COG0344 [S] Predicted membrane protein YP_535763.1 COG0344 [S] Predicted membrane protein YP_535764.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_535765.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_535766.1 COG1293 [K] Predicted RNA-binding protein homologous to eukaryotic snRNP YP_535767.1 COG0583 [K] Transcriptional regulator YP_535768.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535769.1 COG0681 [U] signal peptidase I YP_535770.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535771.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_535772.1 COG1408 [R] Predicted phosphohydrolases YP_535773.1 COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_535774.1 COG1668 [CP] ABC-type Na+ efflux pump, permease component YP_535775.1 COG1101 [R] ABC-type uncharacterized transport system, ATPase component YP_535778.1 COG0776 [L] Bacterial nucleoid DNA-binding protein YP_535779.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_535780.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_535781.1 COG0394 [T] Protein-tyrosine-phosphatase YP_535782.1 COG3966 [M] Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) YP_535783.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_535784.1 COG1696 [M] Predicted membrane protein involved in D-alanine export YP_535785.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_535787.1 COG0353 [L] Recombinational DNA repair protein (RecF pathway) YP_535788.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_535789.1 COG0818 [M] Diacylglycerol kinase YP_535790.1 COG0319 [R] Predicted metal-dependent hydrolase YP_535791.1 COG1702 [T] Phosphate starvation-inducible protein PhoH, predicted ATPase YP_535792.1 COG0860 [M] N-acetylmuramoyl-L-alanine amidase YP_535793.1 COG0283 [F] Cytidylate kinase YP_535795.1 COG0514 [L] Superfamily II DNA helicase YP_535796.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535797.1 COG1914 [P] Mn2+ and Fe2+ transporters of the NRAMP family YP_535798.1 COG0720 [H] 6-pyruvoyl-tetrahydropterin synthase YP_535802.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_535803.1 COG0358 [L] DNA primase (bacterial type) YP_535804.1 COG0751 [J] Glycyl-tRNA synthetase, beta subunit YP_535805.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_535806.1 COG4814 [R] Uncharacterized protein with an alpha/beta hydrolase fold YP_535807.1 COG1455 [G] Phosphotransferase system cellobiose-specific component IIC YP_535808.1 COG0732 [V] Restriction endonuclease S subunits YP_535809.1 COG0732 [V] Restriction endonuclease S subunits YP_535810.1 COG0582 [L] Integrase YP_535811.1 COG0732 [V] Restriction endonuclease S subunits YP_535812.1 COG0286 [V] type I restriction-modification system methyltransferase subunit YP_535813.1 COG0610 [V] type I site-specific restriction-modification system, R (restriction) subunit and related helicases YP_535815.1 COG1051 [F] ADP-ribose pyrophosphatase YP_535816.1 COG0671 [I] Membrane-associated phospholipid phosphatase YP_535817.1 COG0110 [R] acetyltransferase (isoleucine patch superfamily) YP_535821.1 COG0675 [L] Transposase and inactivated derivatives YP_535822.1 COG1001 [F] Adenine deaminase YP_535823.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535824.1 COG1757 [C] Na+/H+ antiporter YP_535825.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_535826.1 COG0744 [M] Membrane carboxypeptidase (penicillin-binding protein) YP_535827.1 COG4974 [L] Site-specific recombinase XerD YP_535828.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535829.1 COG0344 [S] Predicted membrane protein YP_535830.1 COG0344 [S] Predicted membrane protein YP_535831.1 COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_535832.1 COG1386 [K] Predicted transcriptional regulator containing the HTH domain YP_535833.1 COG0011 [S] Uncharacterized conserved protein YP_535839.1 heat shock protein involved in degradation of misfolded proteins YP_535840.1 heat shock protein involved in degradation of misfolded proteins YP_535841.1 COG4974 [L] Site-specific recombinase XerD YP_535842.1 COG2230 [M] Cyclopropane fatty acid synthase and related methyltransferases YP_535843.1 COG1597 [IR] Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase YP_535847.1 involved in the peptidyltransferase reaction during translation YP_535848.1 COG2868 [J] Predicted ribosomal protein YP_535849.1 COG0261 [J] Ribosomal protein L21 YP_535857.1 COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_535858.1 COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_535859.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_535861.1 COG0392 [S] Predicted integral membrane protein YP_535863.1 COG0604 [CR] NADPH:quinone reductase and related Zn-dependent oxidoreductases YP_535864.1 COG0011 [S] Uncharacterized conserved protein YP_535865.1 COG1395 [K] Predicted transcriptional regulator YP_535866.1 COG0702 [MG] Predicted nucleoside-diphosphate-sugar epimerases YP_535869.1 COG0438 [M] Glycosyltransferase YP_535870.1 COG1004 [M] Predicted UDP-glucose 6-dehydrogenase YP_535871.1 COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_535872.1 COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid; flippase YP_535873.1 COG0438 [M] Glycosyltransferase YP_535874.1 COG3754 [M] Lipopolysaccharide biosynthesis protein YP_535875.1 COG3754 [M] Lipopolysaccharide biosynthesis protein YP_535877.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_535878.1 COG1216 [R] Predicted glycosyltransferases YP_535879.1 COG0438 [M] Glycosyltransferase YP_535880.1 COG0438 [M] Glycosyltransferase YP_535881.1 COG0438 [M] Glycosyltransferase YP_535882.1 COG0438 [M] Glycosyltransferase YP_535883.1 COG0110 [R] acetyltransferase (isoleucine patch superfamily) YP_535884.1 COG2148 [M] Sugar transferases involved in lipopolysaccharide synthesis YP_535885.1 COG0399 [M] Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_535886.1 COG1086 [MG] Predicted nucleoside-diphosphate sugar epimerases YP_535887.1 COG0455 [D] ATPases involved in chromosome partitioning; capsular polysaccharide biosynthesis YP_535888.1 COG3944 [M] Capsular polysaccharide biosynthesis protein; capsular polysaccharide biosynthesis YP_535889.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_535890.1 COG0144 [J] tRNA and rRNA cytosine-C5-methylases YP_535892.1 COG1073 [R] Hydrolases of the alpha/beta superfamily YP_535893.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_535894.1 COG1670 [J] acetyltransferases, including N-acetylases of ribosomal proteins YP_535895.1 COG0019 [E] Diaminopimelate decarboxylase YP_535896.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_535897.1 COG4690 [E] Dipeptidase YP_535899.1 COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_535901.1 COG3345 [G] alpha-galactosidase YP_535903.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_535904.1 COG1061 [KL] DNA or RNA helicases of superfamily II YP_535905.1 COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_535906.1 COG0675 [L] Transposase and inactivated derivatives YP_535907.1 COG2200 [T] FOG: EAL domain YP_535908.1 COG2199 [T] FOG: GGDEF domain YP_535909.1 UDP-forming YP_535910.1 COG1215 [M] Glycosyltransferases, probably involved in cell wall biogenesis YP_535911.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535915.1 COG2199 [T] FOG: GGDEF domain YP_535916.1 COG2252 [R] Permeases YP_535917.1 COG1252 [C] NADH dehydrogenase, FAD-containing subunit YP_535918.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_535919.1 COG0142 [H] Geranylgeranyl pyrophosphate synthase YP_535920.1 COG4987 [CO] ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components YP_535921.1 COG4988 [CO] ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components YP_535922.1 COG1294 [C] Cytochrome bd-type quinol oxidase, subunit 2 YP_535923.1 COG1271 [C] Cytochrome bd-type quinol oxidase, subunit 1 YP_535924.1 catalyzes the formation of asparagine from aspartate and ammonia YP_535925.1 COG0513 [LKJ] Superfamily II DNA and RNA helicases YP_535926.1 COG0607 [P] Rhodanese-related sulfurtransferase YP_535928.1 COG0639 [T] Diadenosine tetraphosphatase and related serine/threonine protein phosphatases YP_535929.1 COG1085 [C] Galactose-1-phosphate uridylyltransferase YP_535931.1 COG1397 [O] ADP-ribosylglycohydrolase YP_535932.1 COG0011 [S] Uncharacterized conserved protein YP_535933.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_535934.1 COG3599 [D] Cell division initiation protein YP_535935.1 COG2302 [S] Uncharacterized conserved protein, contains S4-like domain YP_535936.1 COG0392 [S] Predicted integral membrane protein YP_535937.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_535938.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_535939.1 COG0849 [D] Actin-like ATPase involved in cell division YP_535940.1 COG1589 [M] Cell division septal protein YP_535941.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_535942.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_535943.1 COG0472 [M] UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase YP_535944.1 COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_535946.1 COG0275 [M] Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_535947.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_535949.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive YP_535951.1 COG1073 [R] Hydrolases of the alpha/beta superfamily YP_535952.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_535953.1 COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_535954.1 COG0765 [E] ABC-type amino acid transport system, permease component YP_535955.1 COG2894 [D] Septum formation inhibitor-activating ATPase YP_535956.1 COG0850 [D] Septum formation inhibitor YP_535957.1 COG1792 [M] Cell shape-determining protein YP_535958.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_535959.1 functions in MreBCD complex in some organisms YP_535960.1 COG1278 [K] Cold shock proteins YP_535961.1 COG2003 [L] DNA repair proteins YP_535962.1 COG0285 [H] Folylpolyglutamate synthase YP_535963.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_535964.1 COG0301 [H] Thiamine biosynthesis ATP pyrophosphatase YP_535965.1 COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_535966.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_535967.1 COG1956 [T] GAF domain-containing protein YP_535968.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_535970.1 COG2256 [L] ATPase related to the helicase subunit of the Holliday junction resolvase YP_535972.1 COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_535973.1 COG2094 [L] 3-methyladenine DNA glycosylase YP_535974.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_535975.1 COG0006 [E] Xaa-Pro aminopeptidase YP_535976.1 COG3468 [MU] type V secretory pathway, adhesin AidA YP_535977.1 COG0344 [S] Predicted membrane protein YP_535979.1 COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_535980.1 COG0344 [S] Predicted membrane protein YP_535981.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_535982.1 COG0608 [L] Single-stranded DNA-specific exonuclease YP_535983.1 COG0300 [R] Short-chain dehydrogenases of various substrate specificities YP_535984.1 COG1234 [R] Metal-dependent hydrolases of the beta-lactamase superfamily III YP_535987.1 COG1835 [I] Predicted acyltransferases YP_535988.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_535989.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_535990.1 COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases YP_535992.1 COG0622 [R] Predicted phosphoesterase YP_535993.1 COG0127 [F] Xanthosine triphosphate pyrophosphatase YP_535995.1 COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_535996.1 COG0249 [L] Mismatch repair ATPase (MutS family) YP_535997.1 COG1286 [R] Uncharacterized membrane protein, required for colicin V production YP_535999.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536000.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_536001.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536002.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_536003.1 COG0513 [LKJ] Superfamily II DNA and RNA helicases YP_536004.1 COG0618 [R] Exopolyphosphatase-related proteins YP_536005.1 COG0282 [C] Acetate kinase YP_536006.1 COG0011 [S] Uncharacterized conserved protein YP_536007.1 COG1139 [C] Uncharacterized conserved protein containing a ferredoxin-like domain YP_536008.1 COG0247 [C] Fe-S oxidoreductase YP_536009.1 COG0531 [E] Amino acid transporters YP_536011.1 COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_536013.1 COG1862 [U] Preprotein translocase subunit YajC YP_536014.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_536015.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_536016.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_536017.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_536018.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_536019.1 This protein performs the mismatch recognition step during the DNA repair process YP_536020.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_536021.1 COG0468 [L] RecA/RadA recombinase YP_536022.1 COG0558 [I] Phosphatidylglycerophosphate synthase YP_536023.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536024.1 COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_536025.1 COG0612 [R] Predicted Zn-dependent peptidases YP_536026.1 COG1674 [D] DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_536027.1 COG0219 [J] Predicted rRNA methylase (SpoU class) YP_536028.1 COG0500 [QR] SAM-dependent methyltransferases YP_536029.1 COG0011 [S] Uncharacterized conserved protein YP_536030.1 COG0516 [F] IMP dehydrogenase/GMP reductase YP_536031.1 COG1301 [C] Na+/H+-dicarboxylate symporters YP_536033.1 COG2706 [G] 3-carboxymuconate cyclase YP_536034.1 COG3731 [G] Phosphotransferase system sorbitol-specific component IIA YP_536035.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_536036.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536037.1 COG0011 [S] Uncharacterized conserved protein YP_536038.1 COG0344 [S] Predicted membrane protein YP_536039.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_536040.1 COG0847 [L] DNA polymerase III, epsilon subunit and related 3'-5' exonucleases YP_536041.1 COG0802 [R] Predicted ATPase or kinase YP_536042.1 COG0280 [C] Phosphotransacetylase YP_536043.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_536044.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_536046.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_536047.1 COG0557 [K] Exoribonuclease R YP_536048.1 COG1314 [U] Preprotein translocase subunit SecG YP_536049.1 COG0038 [P] Chloride channel protein EriC YP_536050.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536051.1 COG0642 [T] signal transduction histidine kinase YP_536052.1 COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_536053.1 COG0389 [L] Nucleotidyltransferase/DNA polymerase involved in DNA repair YP_536054.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_536055.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_536056.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_536057.1 COG0057 [G] Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_536058.1 COG2390 [K] Transcriptional regulator, contains sigma factor-related N-terminal domain YP_536059.1 COG0740 [OU] Protease subunit of ATP-dependent Clp proteases YP_536060.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536061.1 COG0011 [S] Uncharacterized conserved protein YP_536062.1 COG1660 [R] Predicted P-loop-containing kinase; contains P-loop YP_536063.1 COG0702 [MG] Predicted nucleoside-diphosphate-sugar epimerases YP_536064.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_536065.1 COG0178 [L] Excinuclease ATPase subunit YP_536066.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_536067.1 COG1109 [G] Phosphomannomutase YP_536068.1 COG0682 [M] Prolipoprotein diacylglyceryltransferase YP_536069.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_536070.1 COG0344 [S] Predicted membrane protein YP_536071.1 COG0583 [K] Transcriptional regulator YP_536072.1 COG0642 [T] signal transduction histidine kinase YP_536073.1 COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_536074.1 COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_536075.1 COG0675 [L] Transposase and inactivated derivatives YP_536076.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_536077.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_536078.1 COG2807 [P] Cyanate permease YP_536079.1 COG1544 [J] Ribosome-associated protein Y (PSrp-1) YP_536080.1 COG0582 [L] Integrase YP_536082.1 COG0640 [K] Predicted transcriptional regulators YP_536093.1 COG0433 [R] Predicted ATPase YP_536097.1 COG1040 [R] Predicted amidophosphoribosyltransferases YP_536098.1 COG4098 [L] Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) YP_536099.1 COG0472 [M] UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase YP_536100.1 COG0531 [E] Amino acid transporters YP_536101.1 COG0474 [P] Cation transport ATPase YP_536102.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_536103.1 COG0234 [O] Co-chaperonin GroES (HSP10) YP_536104.1 COG1266 [R] Predicted metal-dependent membrane protease YP_536105.1 modulates transcription in response to the NADH/NAD(+) redox state YP_536106.1 COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_536107.1 COG0533 [O] Metal-dependent proteases with possible chaperone activity YP_536108.1 COG0456 [R] acetyltransferases YP_536109.1 COG1214 [O] Inactive homolog of metal-dependent proteases, molecular chaperone YP_536110.1 COG0252 [EJ] L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D YP_536111.1 COG3884 [I] acyl-ACP thioesterase YP_536112.1 COG0313 [R] Predicted methyltransferases YP_536113.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536114.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_536115.1 COG0125 [F] Thymidylate kinase YP_536117.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_536118.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536119.1 COG2812 [L] DNA polymerase III, gamma/tau subunits YP_536120.1 COG0590 [FJ] Cytosine/adenosine deaminases YP_536121.1 COG0695 [O] Glutaredoxin and related proteins YP_536122.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_536123.1 Catalyzes the rate-limiting step in dNTP synthesis YP_536124.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_536125.1 COG0011 [S] Uncharacterized conserved protein YP_536127.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_536128.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_536129.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_536130.1 binds directly to 23S ribosomal RNA YP_536131.1 COG0250 [K] Transcription antiterminator YP_536133.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_536134.1 COG3688 [R] Predicted RNA-binding protein containing a PIN domain YP_536135.1 COG0566 [J] rRNA methylases YP_536136.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536137.1 COG0215 [J] Cysteinyl-tRNA synthetase YP_536138.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_536139.1 COG4956 [R] Integral membrane protein (PIN domain superfamily) YP_536140.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_536141.1 COG0756 [F] dUTPase YP_536143.1 COG3579 [E] Aminopeptidase C YP_536145.1 COG0588 [G] Phosphoglycerate mutase 1 YP_536146.1 COG0679 [R] Predicted permeases YP_536147.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_536148.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536149.1 COG2183 [K] Transcriptional accessory protein; contains S1 RNA binding domain YP_536150.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_536151.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_536152.1 COG1922 [M] Teichoic acid biosynthesis proteins YP_536153.1 COG1522 [K] Transcriptional regulators YP_536154.1 COG0345 [E] Pyrroline-5-carboxylate reductase YP_536155.1 COG3104 [E] Dipeptide/tripeptide permease YP_536156.1 COG0344 [S] Predicted membrane protein YP_536158.1 COG1210 [M] UDP-glucose pyrophosphorylase YP_536159.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_536160.1 COG0716 [C] Flavodoxins YP_536161.1 COG0344 [S] Predicted membrane protein YP_536162.1 COG0344 [S] Predicted membrane protein YP_536163.1 catalyzes the formation of L-proline from L-ornithine YP_536165.1 COG0640 [K] Predicted transcriptional regulators YP_536166.1 COG0381 [M] UDP-N-acetylglucosamine 2-epimerase YP_536167.1 COG2309 [E] Leucyl aminopeptidase (aminopeptidase T) YP_536168.1 COG0531 [E] Amino acid transporters YP_536169.1 COG0637 [R] Predicted phosphatase/phosphohexomutase YP_536170.1 COG1554 [G] Trehalose and maltose hydrolases (possible phosphorylases) YP_536171.1 COG2017 [G] Galactose mutarotase and related enzymes YP_536172.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536173.1 COG1522 [K] Transcriptional regulators YP_536174.1 COG3158 [P] K+ transporter YP_536176.1 COG0513 [LKJ] Superfamily II DNA and RNA helicases YP_536177.1 COG0673 [R] Predicted dehydrogenases and related proteins YP_536179.1 COG0366 [G] Glycosidases YP_536180.1 COG0058 [G] Glucan phosphorylase YP_536181.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_536182.1 COG0448 [G] ADP-glucose pyrophosphorylase YP_536183.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_536184.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_536185.1 COG0366 [G] Glycosidases YP_536187.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_536188.1 COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_536189.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_536191.1 COG0675 [L] Transposase and inactivated derivatives YP_536192.1 COG2239 [P] Mg/Co/Ni transporter MgtE (contains CBS domain) YP_536193.1 COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_536194.1 catalyzes the phosphorylation of NAD to NADP YP_536195.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536196.1 COG0550 [L] Topoisomerase IA YP_536197.1 COG0110 [R] acetyltransferase (isoleucine patch superfamily) YP_536198.1 COG2233 [F] Xanthine/uracil permeases YP_536199.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_536200.1 COG1705 [NU] Muramidase (flagellum-specific) YP_536201.1 COG0344 [S] Predicted membrane protein YP_536202.1 COG0679 [R] Predicted permeases YP_536203.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_536204.1 COG0583 [K] Transcriptional regulator YP_536205.1 COG0583 [K] Transcriptional regulator YP_536206.1 COG0583 [K] Transcriptional regulator YP_536207.1 COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_536208.1 COG1395 [K] Predicted transcriptional regulator YP_536209.1 COG4086 [S] Predicted secreted protein YP_536210.1 COG0586 [S] Uncharacterized membrane-associated protein YP_536211.1 COG0282 [C] Acetate kinase YP_536212.1 COG0110 [R] acetyltransferase (isoleucine patch superfamily) YP_536213.1 COG0471 [P] Di- and tricarboxylate transporters YP_536214.1 COG1053 [C] Succinate dehydrogenase/fumarate reductase, flavoprotein subunit YP_536215.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_536217.1 COG1249 [C] Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes YP_536218.1 COG1393 [P] Arsenate reductase and related proteins, glutaredoxin family YP_536219.1 COG0602 [O] Organic radical activating enzymes YP_536220.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_536221.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536222.1 COG2388 [R] Predicted acetyltransferase YP_536224.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_536227.1 COG0675 [L] Transposase and inactivated derivatives YP_536229.1 COG2265 [J] SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_536230.1 COG0675 [L] Transposase and inactivated derivatives YP_536231.1 similar to YegS from E. coli YP_536232.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_536233.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_536234.1 COG0721 [J] Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit YP_536235.1 COG4851 [R] Protein involved in sex pheromone biosynthesis YP_536236.1 COG0272 [L] NAD-dependent DNA ligase (contains BRCT domain type II) YP_536237.1 COG0210 [L] Superfamily I DNA and RNA helicases YP_536238.1 COG0026 [F] Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) YP_536239.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_536240.1 COG0042 [J] tRNA-dihydrouridine synthase YP_536241.1 COG0465 [O] ATP-dependent Zn proteases YP_536242.1 COG0634 [F] Hypoxanthine-guanine phosphoribosyltransferase YP_536243.1 COG0037 [D] Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_536244.1 COG1098 [J] Predicted RNA binding protein (contains ribosomal protein S1 domain) YP_536245.1 COG2919 [D] Septum formation initiator YP_536246.1 COG1188 [J] Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_536247.1 COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_536248.1 COG1197 [LK] Transcription-repair coupling factor (superfamily II helicase) YP_536249.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_536250.1 COG0039 [C] Malate/lactate dehydrogenases YP_536251.1 COG1787 [V] Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes YP_536252.1 COG0517 [R] FOG: CBS domain YP_536253.1 COG1893 [H] Ketopantoate reductase YP_536254.1 COG0162 [J] Tyrosyl-tRNA synthetase YP_536255.1 COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_536256.1 COG1988 [R] Predicted membrane-bound metal-dependent hydrolases YP_536257.1 COG0419 [L] ATPase involved in DNA repair YP_536258.1 COG0420 [L] DNA repair exonuclease YP_536260.1 COG0028 [EH] Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] YP_536261.1 COG2173 [M] D-alanyl-D-alanine dipeptidase YP_536262.1 COG0577 [V] ABC-type antimicrobial peptide transport system, permease component YP_536263.1 COG1136 [V] ABC-type antimicrobial peptide transport system, ATPase component YP_536264.1 COG0778 [C] Nitroreductase YP_536265.1 COG0210 [L] Superfamily I DNA and RNA helicases YP_536266.1 COG0475 [P] Kef-type K+ transport systems, membrane components YP_536268.1 COG0675 [L] Transposase and inactivated derivatives YP_536269.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536271.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_536273.1 COG0675 [L] Transposase and inactivated derivatives YP_536274.1 COG2020 [O] protein-S-isoprenylcysteine methyltransferase YP_536275.1 COG3654 [R] Prophage maintenance system killer protein YP_536284.1 COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_536285.1 COG1658 [L] Small primase-like proteins (Toprim domain) YP_536289.1 forms a direct contact with the tRNA during translation YP_536290.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_536291.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_536292.1 COG0619 [P] ABC-type cobalt transport system, permease component CbiQ and related transporters YP_536293.1 COG1122 [P] ABC-type cobalt transport system, ATPase component YP_536294.1 COG1122 [P] ABC-type cobalt transport system, ATPase component YP_536295.1 COG0203 [J] Ribosomal protein L17 YP_536296.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_536297.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_536298.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_536299.1 COG0257 [J] Ribosomal protein L36 YP_536300.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_536301.1 COG0563 [F] Adenylate kinase and related kinases YP_536302.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_536303.1 COG0200 [J] Ribosomal protein L15 YP_536304.1 COG1841 [J] Ribosomal protein L30/L7E YP_536305.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_536306.1 binds 5S rRNA along with protein L5 and L25 YP_536307.1 COG0097 [J] Ribosomal protein L6P/L9E YP_536308.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_536309.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_536310.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_536311.1 COG0198 [J] Ribosomal protein L24 YP_536312.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_536313.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_536314.1 one of the stabilizing components for the large ribosomal subunit YP_536315.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_536316.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_536317.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_536318.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_536319.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_536320.1 COG0089 [J] Ribosomal protein L23 YP_536321.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_536322.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_536323.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_536324.1 COG2262 [R] GTPases YP_536325.1 COG1522 [K] Transcriptional regulators YP_536326.1 COG0120 [G] Ribose 5-phosphate isomerase YP_536327.1 COG0673 [R] Predicted dehydrogenases and related proteins YP_536329.1 COG0531 [E] Amino acid transporters YP_536330.1 COG0765 [E] ABC-type amino acid transport system, permease component YP_536331.1 COG0765 [E] ABC-type amino acid transport system, permease component YP_536332.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_536333.1 COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_536336.1 COG0744 [M] Membrane carboxypeptidase (penicillin-binding protein) YP_536337.1 COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_536338.1 COG0531 [E] Amino acid transporters YP_536339.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_536340.1 COG1061 [KL] DNA or RNA helicases of superfamily II YP_536341.1 COG2365 [T] Protein tyrosine/serine phosphatase YP_536342.1 COG1253 [R] Hemolysins and related proteins containing CBS domains YP_536344.1 COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_536345.1 COG0577 [V] ABC-type antimicrobial peptide transport system, permease component YP_536346.1 COG1136 [V] ABC-type antimicrobial peptide transport system, ATPase component YP_536347.1 COG0845 [M] Membrane-fusion protein YP_536348.1 COG1940 [KG] Transcriptional regulator/sugar kinase YP_536349.1 COG0534 [V] Na+-driven multidrug efflux pump YP_536350.1 COG0346 [E] Lactoylglutathione lyase and related lyases YP_536351.1 COG4814 [R] Uncharacterized protein with an alpha/beta hydrolase fold YP_536352.1 COG0363 [G] 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase YP_536353.1 COG1820 [G] N-acetylglucosamine-6-phosphate deacetylase YP_536354.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_536355.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_536357.1 COG0344 [S] Predicted membrane protein YP_536358.1 COG0675 [L] Transposase and inactivated derivatives YP_536359.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536360.1 COG0239 [D] Integral membrane protein possibly involved in chromosome condensation YP_536361.1 COG0239 [D] Integral membrane protein possibly involved in chromosome condensation YP_536362.1 COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_536363.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_536364.1 COG0583 [K] Transcriptional regulator YP_536365.1 COG0011 [S] Uncharacterized conserved protein YP_536366.1 COG0011 [S] Uncharacterized conserved protein YP_536367.1 COG1278 [K] Cold shock proteins YP_536368.1 COG1321 [K] Mn-dependent transcriptional regulator YP_536369.1 COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_536371.1 COG0671 [I] Membrane-associated phospholipid phosphatase YP_536373.1 COG0657 [I] Esterase/lipase YP_536375.1 COG1296 [E] Predicted branched-chain amino acid permease (azaleucine resistance) YP_536377.1 COG0708 [L] Exonuclease III YP_536378.1 COG0344 [S] Predicted membrane protein YP_536385.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_536386.1 COG1168 [E] Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities YP_536387.1 COG0628 [R] Predicted permease YP_536388.1 COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_536389.1 COG0546 [R] Predicted phosphatases YP_536390.1 COG2017 [G] Galactose mutarotase and related enzymes YP_536391.1 COG0431 [R] Predicted flavoprotein YP_536392.1 COG2141 [C] Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases YP_536393.1 COG0640 [K] Predicted transcriptional regulators YP_536394.1 COG1087 [M] UDP-glucose 4-epimerase YP_536395.1 COG1522 [K] Transcriptional regulators YP_536396.1 COG3957 [G] Phosphoketolase YP_536397.1 COG1335 [Q] Amidases related to nicotinamidase YP_536398.1 COG0406 [G] Fructose-2,6-bisphosphatase YP_536399.1 COG1263 [G] Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_536400.1 COG1522 [K] Transcriptional regulators YP_536401.1 COG0366 [G] Glycosidases YP_536402.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536403.1 COG5263 [R] FOG: Glucan-binding domain (YG repeat) YP_536404.1 COG5263 [R] FOG: Glucan-binding domain (YG repeat) YP_536405.1 COG0083 [E] Homoserine kinase YP_536406.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_536407.1 COG1477 [H] Membrane-associated lipoprotein involved in thiamine biosynthesis YP_536408.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_536409.1 COG5263 [R] FOG: Glucan-binding domain (YG repeat) YP_536411.1 COG0438 [M] Glycosyltransferase YP_536414.1 COG3594 [G] Fucose 4-O-acetylase and related acetyltransferases YP_536415.1 COG1957 [F] Inosine-uridine nucleoside N-ribohydrolase YP_536417.1 COG0431 [R] Predicted flavoprotein YP_536418.1 COG0431 [R] Predicted flavoprotein YP_536419.1 COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_536420.1 COG0475 [P] Kef-type K+ transport systems, membrane components YP_536421.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue YP_536422.1 COG5263 [R] FOG: Glucan-binding domain (YG repeat) YP_536424.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_536425.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_536426.1 COG2755 [E] Lysophospholipase L1 and related esterases YP_536427.1 COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_536428.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_536429.1 COG0531 [E] Amino acid transporters YP_536430.1 COG1694 [R] Predicted pyrophosphatase YP_536431.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536433.1 COG5263 [R] FOG: Glucan-binding domain (YG repeat) YP_536434.1 COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid; flippase YP_536435.1 COG0562 [M] UDP-galactopyranose mutase YP_536437.1 COG2148 [M] Sugar transferases involved in lipopolysaccharide synthesis YP_536438.1 COG0583 [K] Transcriptional regulator YP_536439.1 COG3944 [M] Capsular polysaccharide biosynthesis protein; capsular polysaccharide biosynthesis YP_536440.1 COG0455 [D] ATPases involved in chromosome partitioning; capsular polysaccharide biosynthesis YP_536441.1 COG3944 [M] Capsular polysaccharide biosynthesis protein; capsular polysaccharide biosynthesis YP_536442.1 COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_536443.1 COG0438 [M] Glycosyltransferase YP_536446.1 COG0438 [M] Glycosyltransferase YP_536447.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_536448.1 COG0438 [M] Glycosyltransferase YP_536450.1 COG0675 [L] Transposase and inactivated derivatives YP_536451.1 COG0210 [L] Superfamily I DNA and RNA helicases YP_536452.1 COG3593 [L] Predicted ATP-dependent endonuclease of the OLD family YP_536453.1 COG0344 [S] Predicted membrane protein YP_536455.1 COG1472 [G] beta-glucosidase-related glycosidases YP_536456.1 COG1091 [M] dTDP-4-dehydrorhamnose reductase YP_536457.1 COG1088 [M] dTDP-D-glucose 4,6-dehydratase YP_536458.1 COG1898 [M] dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes YP_536459.1 COG1209 [M] dTDP-glucose pyrophosphorylase YP_536460.1 COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_536462.1 COG1266 [R] Predicted metal-dependent membrane protease YP_536463.1 COG0011 [S] Uncharacterized conserved protein YP_536464.1 COG0637 [R] Predicted phosphatase/phosphohexomutase YP_536465.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536467.1 COG1418 [R] Predicted HD superfamily hydrolase YP_536468.1 COG0640 [K] Predicted transcriptional regulators YP_536470.1 COG0351 [H] Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase YP_536472.1 COG1108 [P] ABC-type Mn2+/Zn2+ transport systems, permease components YP_536473.1 COG1121 [P] ABC-type Mn/Zn transport systems, ATPase component YP_536474.1 COG0803 [P] ABC-type metal ion transport system, periplasmic component/surface adhesin YP_536476.1 COG0596 [R] Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_536478.1 COG4858 [S] Uncharacterized membrane-bound protein conserved in bacteria YP_536479.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_536480.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536481.1 COG0640 [K] Predicted transcriptional regulators YP_536482.1 COG0455 [D] ATPases involved in chromosome partitioning YP_536483.1 COG0640 [K] Predicted transcriptional regulators YP_536484.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_536485.1 COG0039 [C] Malate/lactate dehydrogenases YP_536486.1 COG0584 [C] Glycerophosphoryl diester phosphodiesterase YP_536487.1 COG0474 [P] Cation transport ATPase YP_536488.1 COG1611 [R] Predicted Rossmann fold nucleotide-binding protein YP_536489.1 COG0693 [R] intracellular protease/amidase YP_536491.1 COG3764 [M] Sortase (surface protein transpeptidase) YP_536492.1 COG1074 [L] ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_536493.1 COG3857 [L] ATP-dependent nuclease, subunit B YP_536495.1 COG0462 [FE] Phosphoribosylpyrophosphate synthetase YP_536496.1 COG0014 [E] Gamma-glutamyl phosphate reductase YP_536497.1 COG0263 [E] Glutamate 5-kinase YP_536498.1 COG1482 [G] Phosphomannose isomerase YP_536499.1 COG0011 [S] Uncharacterized conserved protein YP_536501.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_536502.1 COG0640 [K] Predicted transcriptional regulators YP_536503.1 COG0246 [G] Mannitol-1-phosphate/altronate dehydrogenases YP_536504.1 COG4668 [G] Mannitol/fructose-specific phosphotransferase system, IIA domain YP_536505.1 COG2213 [G] Phosphotransferase system, mannitol-specific IIBC component YP_536506.1 COG0861 [P] Membrane protein TerC, possibly involved in tellurium resistance YP_536507.1 COG0583 [K] Transcriptional regulator YP_536508.1 COG0834 [ET] ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_536509.1 COG0675 [L] Transposase and inactivated derivatives YP_536510.1 COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_536511.1 COG0765 [E] ABC-type amino acid transport system, permease component YP_536512.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_536513.1 COG3711 [K] Transcriptional antiterminator YP_536514.1 COG0025 [P] NhaP-type Na+/H+ and K+/H+ antiporters YP_536515.1 COG0580 [G] Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_536516.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536517.1 COG2376 [G] Dihydroxyacetone kinase YP_536518.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_536519.1 similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone YP_536520.1 COG0583 [K] Transcriptional regulator YP_536521.1 COG1114 [E] Branched-chain amino acid permeases YP_536524.1 COG0474 [P] Cation transport ATPase YP_536525.1 COG0640 [K] Predicted transcriptional regulators YP_536526.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_536527.1 COG1428 [F] Deoxynucleoside kinases YP_536528.1 COG3613 [F] Nucleoside 2-deoxyribosyltransferase YP_536529.1 COG1296 [E] Predicted branched-chain amino acid permease (azaleucine resistance) YP_536530.1 COG0344 [S] Predicted membrane protein YP_536531.1 COG1522 [K] Transcriptional regulators YP_536532.1 COG1491 [J] Predicted RNA-binding protein YP_536533.1 COG0582 [L] Integrase YP_536534.1 COG0583 [K] Transcriptional regulator YP_536543.1 COG0433 [R] Predicted ATPase YP_536552.1 COG0583 [K] Transcriptional regulator YP_536553.1 COG0344 [S] Predicted membrane protein YP_536554.1 COG3590 [O] Predicted metalloendopeptidase YP_536555.1 COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_536556.1 COG0392 [S] Predicted integral membrane protein YP_536557.1 COG0344 [S] Predicted membrane protein YP_536558.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_536559.1 COG2957 [E] Peptidylarginine deiminase and related enzymes YP_536560.1 COG0577 [V] ABC-type antimicrobial peptide transport system, permease component YP_536561.1 COG1136 [V] ABC-type antimicrobial peptide transport system, ATPase component YP_536562.1 COG0583 [K] Transcriptional regulator YP_536564.1 COG5651 [N] PPE-repeat proteins YP_536566.1 COG0656 [R] Aldo/keto reductases, related to diketogulonate reductase YP_536567.1 COG0640 [K] Predicted transcriptional regulators YP_536568.1 COG0390 [R] ABC-type uncharacterized transport system, permease component YP_536569.1 COG1101 [R] ABC-type uncharacterized transport system, ATPase component YP_536570.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536571.1 COG0450 [O] Peroxiredoxin YP_536572.1 COG0011 [S] Uncharacterized conserved protein YP_536573.1 COG0583 [K] Transcriptional regulator YP_536574.1 COG2837 [P] Predicted iron-dependent peroxidase YP_536576.1 COG3279 [KT] Response regulator of the LytR/AlgR family YP_536577.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_536578.1 COG0531 [E] Amino acid transporters YP_536579.1 COG0344 [S] Predicted membrane protein YP_536580.1 COG4608 [E] ABC-type oligopeptide transport system, ATPase component YP_536581.1 COG0444 [EP] ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_536582.1 COG0601 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_536583.1 COG0601 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_536584.1 COG4166 [E] ABC-type oligopeptide transport system, periplasmic component YP_536585.1 COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_536586.1 COG0231 [J] Translation elongation factor P (EF-P); translation initiation factor 5A (eIF-5A) YP_536587.1 COG0561 [R] Predicted hydrolases of the HAD superfamily YP_536588.1 COG0406 [G] Fructose-2,6-bisphosphatase YP_536589.1 COG0474 [P] Cation transport ATPase YP_536590.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536591.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536592.1 COG1929 [G] Glycerate kinase YP_536593.1 COG0583 [K] Transcriptional regulator YP_536594.1 COG0693 [R] intracellular protease/amidase YP_536595.1 COG0584 [C] Glycerophosphoryl diester phosphodiesterase YP_536596.1 COG1522 [K] Transcriptional regulators YP_536597.1 COG0366 [G] Glycosidases YP_536598.1 COG2893 [G] Phosphotransferase system, mannose/fructose-specific component IIA YP_536599.1 COG3716 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID YP_536600.1 COG3715 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC YP_536601.1 COG3444 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_536602.1 COG1897 [E] Homoserine trans-succinylase YP_536603.1 COG0031 [E] Cysteine synthase YP_536604.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536606.1 COG1607 [I] acyl-CoA hydrolase YP_536607.1 COG0492 [O] Thioredoxin reductase YP_536609.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_536610.1 COG0716 [C] Flavodoxins YP_536611.1 COG0305 [L] Replicative DNA helicase YP_536612.1 COG0359 [J] Ribosomal protein L9 YP_536613.1 COG3887 [T] Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain YP_536616.1 COG0726 [G] Predicted xylanase/chitin deacetylase YP_536618.1 COG0583 [K] Transcriptional regulator YP_536619.1 COG0344 [S] Predicted membrane protein YP_536620.1 COG1972 [F] Nucleoside permease YP_536621.1 COG0706 [U] Preprotein translocase subunit YidC YP_536622.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_536623.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_536624.1 COG5527 [L] Protein involved in initiation of plasmid replication YP_536626.1 COG0455 [D] ATPases involved in chromosome partitioning YP_536628.1 COG0675 [L] Transposase and inactivated derivatives YP_536630.1 COG0308 [E] Aminopeptidase N YP_536631.1 COG0656 [R] Aldo/keto reductases, related to diketogulonate reductase YP_536632.1 COG2095 [U] Multiple antibiotic transporter YP_536633.1 COG1062 [C] Zn-dependent alcohol dehydrogenases, class III YP_536635.1 COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_536636.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536637.1 COG1070 [G] Sugar (pentulose and hexulose) kinases YP_536638.1 COG0011 [S] Uncharacterized conserved protein YP_536639.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_536640.1 COG0235 [G] Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases YP_536643.1 COG0582 [L] Integrase YP_536647.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536648.1 COG1196 [D] Chromosome segregation ATPases YP_536652.1 COG0464 [O] ATPases of the AAA+ class YP_536655.1 COG0531 [E] Amino acid transporters YP_536656.1 COG0686 [E] Alanine dehydrogenase YP_536657.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536659.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536660.1 COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_536662.1 COG0776 [L] Bacterial nucleoid DNA-binding protein YP_536666.1 COG1018 [C] Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 YP_536667.1 COG0675 [L] Transposase and inactivated derivatives YP_536668.1 COG0675 [L] Transposase and inactivated derivatives YP_536669.1 COG0783 [P] DNA-binding ferritin-like protein (oxidative damage protectant) YP_536670.1 COG0664 [T] cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_536671.1 COG2608 [P] Copper chaperone YP_536673.1 COG0474 [P] Cation transport ATPase YP_536674.1 COG0675 [L] Transposase and inactivated derivatives YP_536675.1 COG0675 [L] Transposase and inactivated derivatives YP_536676.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536677.1 COG0477 [GEPR] Permeases of the major facilitator superfamily YP_536678.1 COG0583 [K] Transcriptional regulator YP_536679.1 COG1082 [G] Sugar phosphate isomerases/epimerases YP_536680.1 COG1028 [IQR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_536681.1 COG1053 [C] Succinate dehydrogenase/fumarate reductase, flavoprotein subunit YP_536682.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_536683.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_536684.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS YP_536688.1 COG3049 [M] Penicillin V acylase and related amidases YP_536689.1 COG2365 [T] Protein tyrosine/serine phosphatase YP_536690.1 COG2197 [TK] Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_536691.1 COG0642 [T] Signal transduction histidine kinase YP_536693.1 COG1131 [V] ABC-type multidrug transport system, ATPase component YP_536694.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_536695.1 COG0036 [G] Pentose-5-phosphate-3-epimerase YP_536701.1 COG3451 [U] Type IV secretory pathway, VirB4 components YP_536705.1 COG3505 [U] Type IV secretory pathway, VirD4 components YP_536709.1 COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_536712.1 COG0550 [L] Topoisomerase IA YP_536714.1 COG0419 [L] ATPase involved in DNA repair YP_536722.1 COG0582 [L] Integrase YP_536723.1 COG0011 [S] Uncharacterized conserved protein YP_536724.1 COG2856 [E] Predicted Zn peptidase YP_536727.1 COG3064 [M] Membrane protein involved in colicin uptake YP_536728.1 COG0583 [K] Transcriptional regulator YP_536761.1 COG1752 [R] Predicted esterase of the alpha-beta hydrolase superfamily YP_536762.1 COG1180 [O] Pyruvate-formate lyase-activating enzyme YP_536763.1 COG1882 [C] Pyruvate-formate lyase YP_536764.1 COG0675 [L] Transposase and inactivated derivatives YP_536765.1 COG0700 [S] Uncharacterized membrane protein YP_536766.1 COG0719 [O] ABC-type transport system involved in Fe-S cluster assembly, permease component YP_536767.1 COG0822 [C] NifU homolog involved in Fe-S cluster formation YP_536768.1 COG0520 [E] Selenocysteine lyase YP_536769.1 COG0719 [O] ABC-type transport system involved in Fe-S cluster assembly, permease component YP_536770.1 COG0396 [O] ABC-type transport system involved in Fe-S cluster assembly, ATPase component YP_536771.1 COG4166 [E] ABC-type oligopeptide transport system, periplasmic component YP_536775.1 COG3641 [R] Predicted membrane protein, putative toxin regulator YP_536776.1 COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases YP_536777.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_536778.1 COG3731 [G] Phosphotransferase system sorbitol-specific component IIA YP_536779.1 COG3732 [G] Phosphotransferase system sorbitol-specific component IIBC YP_536780.1 COG3730 [G] Phosphotransferase system sorbitol-specific component IIC YP_536782.1 COG3711 [K] Transcriptional antiterminator YP_536783.1 Converts D-sorbitol-dphosphate to D-fructose-6-phosphate YP_536789.1 COG2070 [R] Dioxygenases related to 2-nitropropane dioxygenase YP_536790.1 COG1012 [C] NAD-dependent aldehyde dehydrogenases; acetylating YP_536791.1 COG0718 [S] Uncharacterized protein conserved in bacteria YP_536797.1 COG2274 [V] ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain YP_536799.1 COG3279 [KT] Response regulator of the LytR/AlgR family YP_536800.1 COG2972 [T] Predicted signal transduction protein with a C-terminal ATPase domain YP_536814.1 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however YP_536815.1 COG0388 [R] Predicted amidohydrolase YP_536816.1 COG3471 [S] Predicted periplasmic/secreted protein YP_536817.1 COG2151 [R] Predicted metal-sulfur cluster biosynthetic enzyme YP_536818.1 COG1760 [E] L-serine deaminase YP_536819.1 COG1760 [E] L-serine deaminase YP_536820.1 COG2211 [G] Na+/melibiose symporter and related transporters YP_536821.1 COG0673 [R] Predicted dehydrogenases and related proteins YP_536822.1 COG2731 [G] Beta-galactosidase, beta subunit YP_536823.1 COG0105 [F] Nucleoside diphosphate kinase YP_536824.1 COG1940 [KG] Transcriptional regulator/sugar kinase YP_536825.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_536826.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_536827.1 COG1522 [K] Transcriptional regulators YP_536829.1 COG0531 [E] Amino acid transporters YP_536831.1 COG0199 [J] Ribosomal protein S14 YP_536832.1 COG0480 [J] Translation elongation factors (GTPases) YP_536833.1 COG0021 [G] Transketolase YP_536834.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_536835.1 COG0036 [G] Pentose-5-phosphate-3-epimerase YP_536836.1 COG3716 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID YP_536837.1 COG3715 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC YP_536838.1 COG3444 [G] Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_536839.1 COG2893 [G] Phosphotransferase system, mannose/fructose-specific component IIA YP_536840.1 COG1063 [ER] Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_536841.1 COG1349 [KG] Transcriptional regulators of sugar metabolism YP_536842.1 COG3957 [G] Phosphoketolase YP_536843.1 COG0675 [L] Transposase and inactivated derivatives YP_536844.1 COG0675 [L] Transposase and inactivated derivatives