-- dump date   	20120504_151251
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
362948000001	MobA/MobL family; Region: MobA_MobL; pfam03389
362948000002	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
362948000003	Fic family protein [Function unknown]; Region: COG3177
362948000004	Fic/DOC family; Region: Fic; cl00960
362948000005	Helix-turn-helix domains; Region: HTH; cl00088
362948000006	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362948000007	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948000008	P-loop; other site
362948000009	Magnesium ion binding site [ion binding]; other site
362948000010	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948000011	Magnesium ion binding site [ion binding]; other site
362948000012	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
362948000013	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
362948000014	catalytic residues [active]
362948000015	catalytic nucleophile [active]
362948000016	Presynaptic Site I dimer interface [polypeptide binding]; other site
362948000017	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
362948000018	Synaptic Flat tetramer interface [polypeptide binding]; other site
362948000019	Synaptic Site I dimer interface [polypeptide binding]; other site
362948000020	DNA binding site [nucleotide binding]
362948000021	Helix-turn-helix domains; Region: HTH; cl00088
362948000022	DNA-binding interface [nucleotide binding]; DNA binding site
362948000023	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
362948000024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948000025	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362948000026	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362948000027	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
362948000028	Asp23 family; Region: Asp23; cl00574
362948000029	Helix-turn-helix domains; Region: HTH; cl00088
362948000030	putative transposase OrfB; Reviewed; Region: PHA02517
362948000031	HTH-like domain; Region: HTH_21; pfam13276
362948000032	Integrase core domain; Region: rve; cl01316
362948000033	Integrase core domain; Region: rve_3; cl15866
362948000034	Y-family of DNA polymerases; Region: PolY; cl12025
362948000035	active site
362948000036	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362948000037	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
362948000038	PemK-like protein; Region: PemK; cl00995
362948000039	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362948000040	MULE transposase domain; Region: MULE; pfam10551
362948000041	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
362948000042	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
362948000043	active site
362948000044	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
362948000045	nudix motif; other site
362948000046	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
362948000047	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
362948000048	Helix-turn-helix domains; Region: HTH; cl00088
362948000049	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
362948000050	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
362948000051	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
362948000052	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
362948000053	RelB antitoxin; Region: RelB; cl01171
362948000054	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362948000055	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948000056	P-loop; other site
362948000057	Magnesium ion binding site [ion binding]; other site
362948000058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948000059	Magnesium ion binding site [ion binding]; other site
362948000060	Helix-turn-helix domains; Region: HTH; cl00088
362948000061	Fic/DOC family; Region: Fic; cl00960
362948000062	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
362948000063	MobA/MobL family; Region: MobA_MobL; pfam03389
362948000064	Helix-turn-helix domains; Region: HTH; cl00088
362948000065	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
362948000066	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
362948000067	putative NAD(P) binding site [chemical binding]; other site
362948000068	dimer interface [polypeptide binding]; other site
362948000069	Transposase, Mutator family; Region: Transposase_mut; pfam00872
362948000070	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
362948000071	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
362948000072	Walker A/P-loop; other site
362948000073	ATP binding site [chemical binding]; other site
362948000074	Q-loop/lid; other site
362948000075	ABC transporter signature motif; other site
362948000076	Walker B; other site
362948000077	D-loop; other site
362948000078	H-loop/switch region; other site
362948000079	ABC-2 type transporter; Region: ABC2_membrane; cl11417
362948000080	LytTr DNA-binding domain; Region: LytTR; cl04498
362948000081	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
362948000082	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
362948000083	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948000084	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362948000085	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362948000086	similar to putative collagen binding protein Cbn
362948000087	Cobalt transport protein; Region: CbiQ; cl00463
362948000088	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
362948000089	Walker A/P-loop; other site
362948000090	ATP binding site [chemical binding]; other site
362948000091	ABC transporter; Region: ABC_tran; pfam00005
362948000092	Q-loop/lid; other site
362948000093	ABC transporter signature motif; other site
362948000094	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
362948000095	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
362948000096	Walker A/P-loop; other site
362948000097	ATP binding site [chemical binding]; other site
362948000098	Q-loop/lid; other site
362948000099	ABC transporter signature motif; other site
362948000100	Walker B; other site
362948000101	D-loop; other site
362948000102	H-loop/switch region; other site
362948000103	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
362948000104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
362948000105	NMT1-like family; Region: NMT1_2; cl15260
362948000106	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
362948000107	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
362948000108	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
362948000109	Walker A/P-loop; other site
362948000110	ATP binding site [chemical binding]; other site
362948000111	Q-loop/lid; other site
362948000112	ABC transporter signature motif; other site
362948000113	Walker B; other site
362948000114	D-loop; other site
362948000115	H-loop/switch region; other site
362948000116	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
362948000117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948000118	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
362948000119	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
362948000120	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
362948000121	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
362948000122	catalytic residues [active]
362948000123	catalytic nucleophile [active]
362948000124	Presynaptic Site I dimer interface [polypeptide binding]; other site
362948000125	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
362948000126	Synaptic Flat tetramer interface [polypeptide binding]; other site
362948000127	Synaptic Site I dimer interface [polypeptide binding]; other site
362948000128	DNA binding site [nucleotide binding]
362948000129	Helix-turn-helix domains; Region: HTH; cl00088
362948000130	DNA-binding interface [nucleotide binding]; DNA binding site
362948000131	RelB antitoxin; Region: RelB; cl01171
362948000132	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
364254000133	Source DNA is available from Eva McArdle at Alimentary Pharmabiotic Centre (e.mcardle@ucc.ie)
364254000134	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
364254000135	DnaA N-terminal domain; Region: DnaA_N; pfam11638
364254000136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254000137	Walker A motif; other site
364254000138	ATP binding site [chemical binding]; other site
364254000139	Walker B motif; other site
364254000140	arginine finger; other site
364254000141	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
364254000142	DnaA box-binding interface [nucleotide binding]; other site
364254000143	DNA polymerase III subunit beta; Validated; Region: PRK05643
364254000144	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
364254000145	putative DNA binding surface [nucleotide binding]; other site
364254000146	dimer interface [polypeptide binding]; other site
364254000147	beta-clamp/clamp loader binding surface; other site
364254000148	beta-clamp/translesion DNA polymerase binding surface; other site
364254000149	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
364254000150	recombination protein F; Reviewed; Region: recF; PRK00064
364254000151	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
364254000152	Walker A/P-loop; other site
364254000153	ATP binding site [chemical binding]; other site
364254000154	Q-loop/lid; other site
364254000155	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000156	ABC transporter signature motif; other site
364254000157	Walker B; other site
364254000158	D-loop; other site
364254000159	H-loop/switch region; other site
364254000160	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
364254000161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254000162	Mg2+ binding site [ion binding]; other site
364254000163	G-X-G motif; other site
364254000164	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
364254000165	anchoring element; other site
364254000166	dimer interface [polypeptide binding]; other site
364254000167	ATP binding site [chemical binding]; other site
364254000168	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
364254000169	active site
364254000170	putative metal-binding site [ion binding]; other site
364254000171	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
364254000172	DNA gyrase subunit A; Validated; Region: PRK05560
364254000173	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
364254000174	CAP-like domain; other site
364254000175	active site
364254000176	primary dimer interface [polypeptide binding]; other site
364254000177	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
364254000178	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
364254000179	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
364254000180	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
364254000181	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
364254000182	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
364254000183	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
364254000184	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
364254000185	dimer interface [polypeptide binding]; other site
364254000186	ssDNA binding site [nucleotide binding]; other site
364254000187	tetramer (dimer of dimers) interface [polypeptide binding]; other site
364254000188	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
364254000189	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
364254000190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000191	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
364254000192	active site
364254000193	Similar to peptidoglycan-specific endopeptidase, M23 family; nonfunctional due to truncation
364254000194	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
364254000195	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
364254000196	active site
364254000197	dimer interface [polypeptide binding]; other site
364254000198	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
364254000199	Ligand Binding Site [chemical binding]; other site
364254000200	Molecular Tunnel; other site
364254000201	Similar to hypothetical membrane spanning protein; nonfunctional due to frameshift
364254000202	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
364254000203	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
364254000204	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
364254000205	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
364254000206	PYR/PP interface [polypeptide binding]; other site
364254000207	dimer interface [polypeptide binding]; other site
364254000208	tetramer interface [polypeptide binding]; other site
364254000209	TPP binding site [chemical binding]; other site
364254000210	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
364254000211	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
364254000212	TPP-binding site [chemical binding]; other site
364254000213	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
364254000214	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
364254000215	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
364254000216	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254000217	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
364254000218	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
364254000219	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254000220	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
364254000221	aspartate racemase; Region: asp_race; TIGR00035
364254000222	drug efflux system protein MdtG; Provisional; Region: PRK09874
364254000223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000224	putative substrate translocation pore; other site
364254000225	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254000226	Sugar transport protein; Region: Sugar_transport; pfam06800
364254000227	Uncharacterized conserved protein [Function unknown]; Region: COG2966
364254000228	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
364254000229	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
364254000230	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
364254000231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254000232	Coenzyme A binding pocket [chemical binding]; other site
364254000233	EamA-like transporter family; Region: EamA; cl01037
364254000234	EamA-like transporter family; Region: EamA; cl01037
364254000235	oligoendopeptidase F; Region: pepF; TIGR00181
364254000236	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
364254000237	active site
364254000238	Zn binding site [ion binding]; other site
364254000239	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
364254000240	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
364254000241	dimer interface [polypeptide binding]; other site
364254000242	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254000243	catalytic residue [active]
364254000244	cystathionine beta-lyase; Provisional; Region: PRK07671
364254000245	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
364254000246	homodimer interface [polypeptide binding]; other site
364254000247	substrate-cofactor binding pocket; other site
364254000248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254000249	catalytic residue [active]
364254000250	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
364254000251	Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171
364254000252	putative active site [active]
364254000253	metal binding site [ion binding]; metal-binding site
364254000254	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
364254000255	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
364254000256	RelB antitoxin; Region: RelB; cl01171
364254000257	Similar to hypothetical protein; nonfunctional due to frameshift and interrupting stop codon
364254000258	Similar to conserved hypothetical protein; nonfunctional due to frameshift
364254000259	Helix-turn-helix domains; Region: HTH; cl00088
364254000260	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
364254000261	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
364254000262	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000263	Walker A/P-loop; other site
364254000264	ATP binding site [chemical binding]; other site
364254000265	Q-loop/lid; other site
364254000266	ABC transporter signature motif; other site
364254000267	Walker B; other site
364254000268	D-loop; other site
364254000269	H-loop/switch region; other site
364254000270	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
364254000271	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
364254000272	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
364254000273	Walker A/P-loop; other site
364254000274	ATP binding site [chemical binding]; other site
364254000275	Q-loop/lid; other site
364254000276	ABC transporter signature motif; other site
364254000277	Walker B; other site
364254000278	D-loop; other site
364254000279	H-loop/switch region; other site
364254000280	sugar phosphate phosphatase; Provisional; Region: PRK10513
364254000281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254000282	active site
364254000283	motif I; other site
364254000284	motif II; other site
364254000285	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254000286	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
364254000287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254000288	active site
364254000289	phosphorylation site [posttranslational modification]
364254000290	intermolecular recognition site; other site
364254000291	dimerization interface [polypeptide binding]; other site
364254000292	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
364254000293	DNA binding site [nucleotide binding]
364254000294	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
364254000295	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
364254000296	dimerization interface [polypeptide binding]; other site
364254000297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
364254000298	putative active site [active]
364254000299	heme pocket [chemical binding]; other site
364254000300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
364254000301	dimer interface [polypeptide binding]; other site
364254000302	phosphorylation site [posttranslational modification]
364254000303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254000304	ATP binding site [chemical binding]; other site
364254000305	Mg2+ binding site [ion binding]; other site
364254000306	G-X-G motif; other site
364254000307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
364254000308	YycH protein; Region: YycH; pfam07435
364254000309	YycH protein; Region: YycI; cl02015
364254000310	Similar to conserved hypothetical protein; nonfunctional due to frameshift
364254000311	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254000312	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
364254000313	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
364254000314	protein binding site [polypeptide binding]; other site
364254000315	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
364254000316	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
364254000317	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
364254000318	NADH(P)-binding; Region: NAD_binding_10; pfam13460
364254000319	putative NAD(P) binding site [chemical binding]; other site
364254000320	Helix-turn-helix domains; Region: HTH; cl00088
364254000321	short chain dehydrogenase; Provisional; Region: PRK06180
364254000322	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
364254000323	NADP binding site [chemical binding]; other site
364254000324	active site
364254000325	steroid binding site; other site
364254000326	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
364254000327	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
364254000328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000329	putative substrate translocation pore; other site
364254000330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
364254000332	Helix-turn-helix domains; Region: HTH; cl00088
364254000333	Similar to transposase ISLasa2a, IS1223 family; nonfunctional due to frameshift
364254000334	Transposase IS200 like; Region: Y1_Tnp; cl00848
364254000335	Similar to reverse transcriptase; nonfunctional due to interrupting stop codon
364254000336	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
364254000337	MatE; Region: MatE; cl10513
364254000338	MatE; Region: MatE; cl10513
364254000339	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
364254000340	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254000341	ABC transporter; Region: ABC_tran_2; pfam12848
364254000342	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254000343	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254000344	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
364254000345	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
364254000346	active site
364254000347	Peptidase C26; Region: Peptidase_C26; pfam07722
364254000348	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
364254000349	catalytic triad [active]
364254000350	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791
364254000351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254000352	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
364254000353	Walker A motif; other site
364254000354	ATP binding site [chemical binding]; other site
364254000355	Walker B motif; other site
364254000356	arginine finger; other site
364254000357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254000358	Walker A motif; other site
364254000359	ATP binding site [chemical binding]; other site
364254000360	Walker B motif; other site
364254000361	arginine finger; other site
364254000362	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254000363	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
364254000364	Ligand Binding Site [chemical binding]; other site
364254000365	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254000366	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254000367	substrate binding pocket [chemical binding]; other site
364254000368	membrane-bound complex binding site; other site
364254000369	hinge residues; other site
364254000370	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
364254000371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254000372	dimer interface [polypeptide binding]; other site
364254000373	conserved gate region; other site
364254000374	putative PBP binding loops; other site
364254000375	ABC-ATPase subunit interface; other site
364254000376	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
364254000377	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
364254000378	homodimer interface [polypeptide binding]; other site
364254000379	substrate-cofactor binding pocket; other site
364254000380	catalytic residue [active]
364254000381	Transcriptional regulators [Transcription]; Region: PurR; COG1609
364254000382	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
364254000383	DNA binding site [nucleotide binding]
364254000384	domain linker motif; other site
364254000385	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
364254000386	dimerization interface [polypeptide binding]; other site
364254000387	ligand binding site [chemical binding]; other site
364254000388	sodium binding site [ion binding]; other site
364254000389	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
364254000390	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
364254000391	substrate binding [chemical binding]; other site
364254000392	active site
364254000393	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
364254000394	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
364254000395	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
364254000396	active site turn [active]
364254000397	phosphorylation site [posttranslational modification]
364254000398	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254000399	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
364254000400	HPr interaction site; other site
364254000401	glycerol kinase (GK) interaction site [polypeptide binding]; other site
364254000402	active site
364254000403	phosphorylation site [posttranslational modification]
364254000404	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
364254000405	homodimer interface [polypeptide binding]; other site
364254000406	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
364254000407	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
364254000408	active site
364254000409	catalytic site [active]
364254000410	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
364254000411	Cation transport protein; Region: TrkH; cl10514
364254000412	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
364254000413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000414	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
364254000415	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5549
364254000416	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
364254000417	active site
364254000418	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
364254000419	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
364254000420	active site
364254000421	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
364254000422	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
364254000423	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
364254000424	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254000425	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
364254000426	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
364254000427	Helix-turn-helix domains; Region: HTH; cl00088
364254000428	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
364254000429	Similar to hydrolase (HAD superfamily); nonfunctional due to frameshift
364254000430	Similar to immunity protein PlnL; nonfunctional due to frameshift
364254000431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000432	Major Facilitator Superfamily; Region: MFS_1; pfam07690
364254000433	putative substrate translocation pore; other site
364254000434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000435	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
364254000436	DNA binding residues [nucleotide binding]
364254000437	putative dimer interface [polypeptide binding]; other site
364254000438	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
364254000439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
364254000440	putative metal binding site [ion binding]; other site
364254000441	Protein of unknown function (DUF554); Region: DUF554; cl00784
364254000442	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
364254000443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254000444	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
364254000445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254000446	active site
364254000447	phosphorylation site [posttranslational modification]
364254000448	intermolecular recognition site; other site
364254000449	dimerization interface [polypeptide binding]; other site
364254000450	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
364254000451	DNA binding residues [nucleotide binding]
364254000452	dimerization interface [polypeptide binding]; other site
364254000453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
364254000454	Histidine kinase; Region: HisKA_3; pfam07730
364254000455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
364254000456	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
364254000457	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
364254000458	ligand binding site [chemical binding]; other site
364254000459	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
364254000460	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
364254000461	active pocket/dimerization site; other site
364254000462	active site
364254000463	phosphorylation site [posttranslational modification]
364254000464	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
364254000465	active site
364254000466	phosphorylation site [posttranslational modification]
364254000467	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
364254000468	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
364254000469	Domain of unknown function (DUF956); Region: DUF956; cl01917
364254000470	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254000471	putative peptidoglycan binding site; other site
364254000472	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
364254000473	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254000474	putative peptidoglycan binding site; other site
364254000475	NlpC/P60 family; Region: NLPC_P60; cl11438
364254000476	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
364254000477	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
364254000478	catalytic residue [active]
364254000479	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
364254000480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000481	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
364254000482	L-serine binding site [chemical binding]; other site
364254000483	ACT domain interface; other site
364254000484	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
364254000485	putative uracil binding site [chemical binding]; other site
364254000486	putative active site [active]
364254000487	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
364254000488	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
364254000489	RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207
364254000490	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
364254000491	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
364254000492	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
364254000493	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cl09913
364254000494	Helix-turn-helix domains; Region: HTH; cl00088
364254000495	Protein of unknown function (DUF1700); Region: DUF1700; cl01933
364254000496	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
364254000497	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
364254000498	PspC domain; Region: PspC; cl00864
364254000499	Enterocin A Immunity; Region: EntA_Immun; pfam08951
364254000500	glycerol kinase; Provisional; Region: glpK; PRK00047
364254000501	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
364254000502	N- and C-terminal domain interface [polypeptide binding]; other site
364254000503	active site
364254000504	MgATP binding site [chemical binding]; other site
364254000505	catalytic site [active]
364254000506	metal binding site [ion binding]; metal-binding site
364254000507	glycerol binding site [chemical binding]; other site
364254000508	homotetramer interface [polypeptide binding]; other site
364254000509	homodimer interface [polypeptide binding]; other site
364254000510	FBP binding site [chemical binding]; other site
364254000511	protein IIAGlc interface [polypeptide binding]; other site
364254000512	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
364254000513	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
364254000514	amphipathic channel; other site
364254000515	Asn-Pro-Ala signature motifs; other site
364254000516	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
364254000517	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
364254000518	Walker A/P-loop; other site
364254000519	ATP binding site [chemical binding]; other site
364254000520	Q-loop/lid; other site
364254000521	ABC transporter signature motif; other site
364254000522	Walker B; other site
364254000523	D-loop; other site
364254000524	H-loop/switch region; other site
364254000525	TOBE domain; Region: TOBE_2; cl01440
364254000526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254000527	dimer interface [polypeptide binding]; other site
364254000528	conserved gate region; other site
364254000529	putative PBP binding loops; other site
364254000530	ABC-ATPase subunit interface; other site
364254000531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254000532	dimer interface [polypeptide binding]; other site
364254000533	conserved gate region; other site
364254000534	ABC-ATPase subunit interface; other site
364254000535	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
364254000536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254000537	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254000538	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
364254000539	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
364254000540	zinc binding site [ion binding]; other site
364254000541	putative ligand binding site [chemical binding]; other site
364254000542	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
364254000543	TM-ABC transporter signature motif; other site
364254000544	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
364254000545	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000546	Walker A/P-loop; other site
364254000547	ATP binding site [chemical binding]; other site
364254000548	Q-loop/lid; other site
364254000549	ABC transporter signature motif; other site
364254000550	Walker B; other site
364254000551	D-loop; other site
364254000552	H-loop/switch region; other site
364254000553	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
364254000554	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
364254000555	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
364254000556	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
364254000557	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
364254000558	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
364254000559	trmE is a tRNA modification GTPase; Region: trmE; cd04164
364254000560	G1 box; other site
364254000561	GTP/Mg2+ binding site [chemical binding]; other site
364254000562	Switch I region; other site
364254000563	G2 box; other site
364254000564	Switch II region; other site
364254000565	G3 box; other site
364254000566	G4 box; other site
364254000567	G5 box; other site
364254000568	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
364254000569	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
364254000570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000571	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
364254000572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254000573	catalytic core [active]
364254000574	CAAX protease self-immunity; Region: Abi; cl00558
364254000575	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254000576	Cupin domain; Region: Cupin_2; cl09118
364254000577	Similar to 4-carboxymuconolactone decarboxylase; nonfunctional due to interrupting stop codon
364254000578	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
364254000579	substrate binding site [chemical binding]; other site
364254000580	THF binding site; other site
364254000581	zinc-binding site [ion binding]; other site
364254000582	NMT1-like family; Region: NMT1_2; cl15260
364254000583	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
364254000584	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
364254000585	Walker A/P-loop; other site
364254000586	ATP binding site [chemical binding]; other site
364254000587	Q-loop/lid; other site
364254000588	ABC transporter signature motif; other site
364254000589	Walker B; other site
364254000590	D-loop; other site
364254000591	H-loop/switch region; other site
364254000592	NIL domain; Region: NIL; cl09633
364254000593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
364254000594	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
364254000595	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
364254000596	metal binding site [ion binding]; metal-binding site
364254000597	dimer interface [polypeptide binding]; other site
364254000598	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
364254000599	dimer interface [polypeptide binding]; other site
364254000600	FMN binding site [chemical binding]; other site
364254000601	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
364254000602	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
364254000603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000604	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
364254000605	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
364254000606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254000607	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
364254000608	ornithine decarboxylase; Provisional; Region: PRK13578
364254000609	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
364254000610	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
364254000611	catalytic residue [active]
364254000612	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
364254000613	Similar to ABC transporter, ATP-binding protein; nonfunctional due to frameshift
364254000614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254000615	dimer interface [polypeptide binding]; other site
364254000616	conserved gate region; other site
364254000617	ABC-ATPase subunit interface; other site
364254000618	NMT1-like family; Region: NMT1_2; cl15260
364254000619	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
364254000620	glucose-1-dehydrogenase; Provisional; Region: PRK08936
364254000621	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
364254000622	NAD binding site [chemical binding]; other site
364254000623	homodimer interface [polypeptide binding]; other site
364254000624	active site
364254000625	Sugar transport protein; Region: Sugar_transport; pfam06800
364254000626	Helix-turn-helix domains; Region: HTH; cl00088
364254000627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254000628	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
364254000629	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
364254000630	active site
364254000631	catalytic tetrad [active]
364254000632	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
364254000633	classical (c) SDRs; Region: SDR_c; cd05233
364254000634	NAD(P) binding site [chemical binding]; other site
364254000635	active site
364254000636	Similar to mucus binding protein Mbp1; nonfunctional due to interrupting stop codon
364254000637	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
364254000638	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
364254000639	tetramer interface [polypeptide binding]; other site
364254000640	TPP-binding site [chemical binding]; other site
364254000641	heterodimer interface [polypeptide binding]; other site
364254000642	phosphorylation loop region [posttranslational modification]
364254000643	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
364254000644	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
364254000645	alpha subunit interface [polypeptide binding]; other site
364254000646	TPP binding site [chemical binding]; other site
364254000647	heterodimer interface [polypeptide binding]; other site
364254000648	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
364254000649	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
364254000650	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
364254000651	E3 interaction surface; other site
364254000652	lipoyl attachment site [posttranslational modification]; other site
364254000653	e3 binding domain; Region: E3_binding; pfam02817
364254000654	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
364254000655	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
364254000656	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254000657	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
364254000658	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
364254000659	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
364254000660	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
364254000661	Protein of unknown function (DUF975); Region: DUF975; cl10504
364254000662	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
364254000663	active site
364254000664	oxyanion hole [active]
364254000665	catalytic triad [active]
364254000666	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
364254000667	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
364254000668	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
364254000669	Helix-turn-helix domains; Region: HTH; cl00088
364254000670	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
364254000671	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
364254000672	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
364254000673	putative substrate binding site [chemical binding]; other site
364254000674	putative ATP binding site [chemical binding]; other site
364254000675	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
364254000676	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
364254000677	active site
364254000678	phosphorylation site [posttranslational modification]
364254000679	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
364254000680	active site
364254000681	P-loop; other site
364254000682	phosphorylation site [posttranslational modification]
364254000683	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254000684	Amino acid permease; Region: AA_permease_2; pfam13520
364254000685	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
364254000686	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
364254000687	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254000688	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
364254000689	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
364254000690	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
364254000691	Ligand binding site; other site
364254000692	Putative Catalytic site; other site
364254000693	DXD motif; other site
364254000694	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
364254000695	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
364254000696	catalytic triad [active]
364254000697	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
364254000698	CoenzymeA binding site [chemical binding]; other site
364254000699	subunit interaction site [polypeptide binding]; other site
364254000700	PHB binding site; other site
364254000701	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
364254000702	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
364254000703	substrate binding site [chemical binding]; other site
364254000704	oxyanion hole (OAH) forming residues; other site
364254000705	trimer interface [polypeptide binding]; other site
364254000706	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
364254000707	AMP-binding enzyme; Region: AMP-binding; cl15778
364254000708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
364254000709	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
364254000710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000711	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
364254000712	Helix-turn-helix domains; Region: HTH; cl00088
364254000713	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
364254000714	Peptidase family C69; Region: Peptidase_C69; pfam03577
364254000715	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
364254000716	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
364254000717	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
364254000718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
364254000719	Helix-turn-helix domains; Region: HTH; cl00088
364254000720	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
364254000721	dimerization interface [polypeptide binding]; other site
364254000722	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
364254000723	active site
364254000724	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
364254000725	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254000726	acetolactate synthase; Reviewed; Region: PRK08617
364254000727	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
364254000728	PYR/PP interface [polypeptide binding]; other site
364254000729	dimer interface [polypeptide binding]; other site
364254000730	TPP binding site [chemical binding]; other site
364254000731	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
364254000732	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
364254000733	TPP-binding site [chemical binding]; other site
364254000734	dimer interface [polypeptide binding]; other site
364254000735	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
364254000736	lysine transporter; Provisional; Region: PRK10836
364254000737	seryl-tRNA synthetase; Provisional; Region: PRK05431
364254000738	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
364254000739	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
364254000740	dimer interface [polypeptide binding]; other site
364254000741	active site
364254000742	motif 1; other site
364254000743	motif 2; other site
364254000744	motif 3; other site
364254000745	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
364254000746	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
364254000747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000748	dihydroorotase; Validated; Region: pyrC; PRK09357
364254000749	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
364254000750	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
364254000751	active site
364254000752	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
364254000753	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
364254000754	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
364254000755	catalytic site [active]
364254000756	subunit interface [polypeptide binding]; other site
364254000757	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
364254000758	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
364254000759	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254000760	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
364254000761	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
364254000762	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254000763	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
364254000764	IMP binding site; other site
364254000765	dimer interface [polypeptide binding]; other site
364254000766	interdomain contacts; other site
364254000767	partial ornithine binding site; other site
364254000768	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
364254000769	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
364254000770	heterodimer interface [polypeptide binding]; other site
364254000771	active site
364254000772	FMN binding site [chemical binding]; other site
364254000773	homodimer interface [polypeptide binding]; other site
364254000774	substrate binding site [chemical binding]; other site
364254000775	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
364254000776	Clp protease ATP binding subunit; Region: clpC; CHL00095
364254000777	Clp amino terminal domain; Region: Clp_N; pfam02861
364254000778	Clp amino terminal domain; Region: Clp_N; pfam02861
364254000779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254000780	Walker A motif; other site
364254000781	ATP binding site [chemical binding]; other site
364254000782	Walker B motif; other site
364254000783	arginine finger; other site
364254000784	UvrB/uvrC motif; Region: UVR; pfam02151
364254000785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254000786	Walker A motif; other site
364254000787	ATP binding site [chemical binding]; other site
364254000788	Walker B motif; other site
364254000789	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254000790	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
364254000791	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
364254000792	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
364254000793	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
364254000794	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
364254000795	RPB1 interaction site [polypeptide binding]; other site
364254000796	RPB10 interaction site [polypeptide binding]; other site
364254000797	RPB11 interaction site [polypeptide binding]; other site
364254000798	RPB3 interaction site [polypeptide binding]; other site
364254000799	RPB12 interaction site [polypeptide binding]; other site
364254000800	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
364254000801	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
364254000802	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
364254000803	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
364254000804	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
364254000805	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
364254000806	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
364254000807	DNA binding site [nucleotide binding]
364254000808	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
364254000809	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
364254000810	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
364254000811	16S rRNA interaction site [nucleotide binding]; other site
364254000812	streptomycin interaction site [chemical binding]; other site
364254000813	23S rRNA interaction site [nucleotide binding]; other site
364254000814	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
364254000815	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
364254000816	elongation factor G; Reviewed; Region: PRK12739
364254000817	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
364254000818	G1 box; other site
364254000819	putative GEF interaction site [polypeptide binding]; other site
364254000820	GTP/Mg2+ binding site [chemical binding]; other site
364254000821	Switch I region; other site
364254000822	G2 box; other site
364254000823	G3 box; other site
364254000824	Switch II region; other site
364254000825	G4 box; other site
364254000826	G5 box; other site
364254000827	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
364254000828	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
364254000829	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
364254000830	NAD-dependent deacetylase; Provisional; Region: PRK00481
364254000831	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
364254000832	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
364254000833	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254000834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254000835	homodimer interface [polypeptide binding]; other site
364254000836	catalytic residue [active]
364254000837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
364254000838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254000839	active site
364254000840	phosphorylation site [posttranslational modification]
364254000841	intermolecular recognition site; other site
364254000842	dimerization interface [polypeptide binding]; other site
364254000843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
364254000844	DNA binding site [nucleotide binding]
364254000845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
364254000846	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
364254000847	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
364254000848	dimer interface [polypeptide binding]; other site
364254000849	phosphorylation site [posttranslational modification]
364254000850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254000851	ATP binding site [chemical binding]; other site
364254000852	Mg2+ binding site [ion binding]; other site
364254000853	G-X-G motif; other site
364254000854	Similar to transposase ISLasa4a, ISL3 family; nonfunctional due to interrupting stop codon
364254000855	Similar to transposase ISLasa4b, ISL3 family; nonfunctional due to interrupting stop codon
364254000856	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
364254000857	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
364254000858	active site
364254000859	catalytic residues [active]
364254000860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254000861	D-galactonate transporter; Region: 2A0114; TIGR00893
364254000862	putative substrate translocation pore; other site
364254000863	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
364254000864	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
364254000865	TPP-binding site; other site
364254000866	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
364254000867	PYR/PP interface [polypeptide binding]; other site
364254000868	dimer interface [polypeptide binding]; other site
364254000869	TPP binding site [chemical binding]; other site
364254000870	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
364254000871	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
364254000872	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
364254000873	Walker A/P-loop; other site
364254000874	ATP binding site [chemical binding]; other site
364254000875	Q-loop/lid; other site
364254000876	ABC transporter signature motif; other site
364254000877	Walker B; other site
364254000878	D-loop; other site
364254000879	H-loop/switch region; other site
364254000880	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
364254000881	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
364254000882	FtsX-like permease family; Region: FtsX; cl15850
364254000883	Helix-turn-helix domains; Region: HTH; cl00088
364254000884	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
364254000885	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
364254000886	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000887	Walker A/P-loop; other site
364254000888	ATP binding site [chemical binding]; other site
364254000889	Q-loop/lid; other site
364254000890	ABC transporter signature motif; other site
364254000891	Walker B; other site
364254000892	D-loop; other site
364254000893	H-loop/switch region; other site
364254000894	Similar to ABC transporter, ATP-binding protein; nonfunctional due to interrupting stop codon
364254000895	Similar to acetyltransferase, GNAT family; nonfunctional due to frameshift
364254000896	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
364254000897	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
364254000898	putative ADP-ribose binding site [chemical binding]; other site
364254000899	putative active site [active]
364254000900	LemA family; Region: LemA; cl00742
364254000901	Peptidase family M48; Region: Peptidase_M48; cl12018
364254000902	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
364254000903	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000904	Family description; Region: UvrD_C_2; cl15862
364254000905	Cation efflux family; Region: Cation_efflux; cl00316
364254000906	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
364254000907	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
364254000908	active site
364254000909	HIGH motif; other site
364254000910	dimer interface [polypeptide binding]; other site
364254000911	KMSKS motif; other site
364254000912	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
364254000913	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
364254000914	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254000915	Walker A/P-loop; other site
364254000916	ATP binding site [chemical binding]; other site
364254000917	Q-loop/lid; other site
364254000918	ABC transporter signature motif; other site
364254000919	Walker B; other site
364254000920	D-loop; other site
364254000921	H-loop/switch region; other site
364254000922	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
364254000923	ABC-2 type transporter; Region: ABC2_membrane; cl11417
364254000924	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254000925	Helix-turn-helix domains; Region: HTH; cl00088
364254000926	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
364254000927	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
364254000928	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254000929	substrate binding pocket [chemical binding]; other site
364254000930	membrane-bound complex binding site; other site
364254000931	hinge residues; other site
364254000932	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
364254000933	homodimer interface [polypeptide binding]; other site
364254000934	catalytic residues [active]
364254000935	NAD binding site [chemical binding]; other site
364254000936	substrate binding pocket [chemical binding]; other site
364254000937	flexible flap; other site
364254000938	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
364254000939	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
364254000940	active site
364254000941	HIGH motif; other site
364254000942	KMSKS motif; other site
364254000943	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
364254000944	tRNA binding surface [nucleotide binding]; other site
364254000945	anticodon binding site; other site
364254000946	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
364254000947	dimer interface [polypeptide binding]; other site
364254000948	putative tRNA-binding site [nucleotide binding]; other site
364254000949	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
364254000950	active site
364254000951	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
364254000952	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
364254000953	putative active site [active]
364254000954	putative metal binding site [ion binding]; other site
364254000955	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
364254000956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254000957	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
364254000958	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
364254000959	transaminase; Validated; Region: PRK07324
364254000960	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254000961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254000962	homodimer interface [polypeptide binding]; other site
364254000963	catalytic residue [active]
364254000964	Arginine repressor [Transcription]; Region: ArgR; COG1438
364254000965	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
364254000966	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
364254000967	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
364254000968	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
364254000969	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
364254000970	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
364254000971	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
364254000972	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254000973	Int/Topo IB signature motif; other site
364254000974	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
364254000975	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
364254000976	P-loop; other site
364254000977	Magnesium ion binding site [ion binding]; other site
364254000978	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
364254000979	Magnesium ion binding site [ion binding]; other site
364254000980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254000981	non-specific DNA binding site [nucleotide binding]; other site
364254000982	salt bridge; other site
364254000983	sequence-specific DNA binding site [nucleotide binding]; other site
364254000984	SOS regulatory protein LexA; Region: lexA; TIGR00498
364254000985	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
364254000986	Catalytic site [active]
364254000987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254000988	non-specific DNA binding site [nucleotide binding]; other site
364254000989	salt bridge; other site
364254000990	sequence-specific DNA binding site [nucleotide binding]; other site
364254000991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254000992	non-specific DNA binding site [nucleotide binding]; other site
364254000993	salt bridge; other site
364254000994	sequence-specific DNA binding site [nucleotide binding]; other site
364254000995	AntA/AntB antirepressor; Region: AntA; cl01430
364254000996	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
364254000997	Protein of unknown function (DUF968); Region: DUF968; pfam06147
364254000998	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
364254000999	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
364254001000	Predicted membrane protein (DUF2335); Region: DUF2335; cl02210
364254001001	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
364254001002	Phage terminase, small subunit; Region: Terminase_4; cl01525
364254001003	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
364254001004	Phage Terminase; Region: Terminase_1; pfam03354
364254001005	Protein of unknown function (DUF1056); Region: DUF1056; pfam06341
364254001006	Phage-related protein [Function unknown]; Region: COG4695; cl01923
364254001007	Phage portal protein; Region: Phage_portal; pfam04860
364254001008	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
364254001009	oligomer interface [polypeptide binding]; other site
364254001010	active site residues [active]
364254001011	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
364254001012	Phage capsid family; Region: Phage_capsid; pfam05065
364254001013	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
364254001014	oligomerization interface [polypeptide binding]; other site
364254001015	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
364254001016	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
364254001017	Protein of unknown function (DUF806); Region: DUF806; pfam05657
364254001018	Phage major tail protein; Region: Phage_tail; pfam04630
364254001019	Phage-related tail protein [Function unknown]; Region: COG5283
364254001020	tape measure domain; Region: tape_meas_nterm; TIGR02675
364254001021	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
364254001022	Phage tail protein; Region: Sipho_tail; pfam05709
364254001023	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
364254001024	Peptidase family M23; Region: Peptidase_M23; pfam01551
364254001025	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
364254001026	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
364254001027	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
364254001028	active site
364254001029	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
364254001030	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
364254001031	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
364254001032	active site
364254001033	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254001034	putative peptidoglycan binding site; other site
364254001035	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254001036	putative peptidoglycan binding site; other site
364254001037	argininosuccinate lyase; Provisional; Region: PRK00855
364254001038	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
364254001039	active sites [active]
364254001040	tetramer interface [polypeptide binding]; other site
364254001041	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
364254001042	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
364254001043	ANP binding site [chemical binding]; other site
364254001044	Substrate Binding Site II [chemical binding]; other site
364254001045	Substrate Binding Site I [chemical binding]; other site
364254001046	aromatic amino acid aminotransferase; Validated; Region: PRK07309
364254001047	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254001048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254001049	homodimer interface [polypeptide binding]; other site
364254001050	catalytic residue [active]
364254001051	D-lactate dehydrogenase; Validated; Region: PRK08605
364254001052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254001053	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254001054	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
364254001055	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001056	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001057	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001058	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001059	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001060	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001061	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001062	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001063	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254001064	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254001065	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
364254001066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254001067	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
364254001068	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
364254001069	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
364254001070	DNA binding residues [nucleotide binding]
364254001071	putative dimer interface [polypeptide binding]; other site
364254001072	pur operon repressor; Provisional; Region: PRK09213
364254001073	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
364254001074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254001075	active site
364254001076	H+ Antiporter protein; Region: 2A0121; TIGR00900
364254001077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254001078	putative substrate translocation pore; other site
364254001079	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
364254001080	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
364254001081	Substrate binding site; other site
364254001082	Mg++ binding site; other site
364254001083	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
364254001084	active site
364254001085	substrate binding site [chemical binding]; other site
364254001086	CoA binding site [chemical binding]; other site
364254001087	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
364254001088	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
364254001089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254001090	active site
364254001091	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
364254001092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254001093	Coenzyme A binding pocket [chemical binding]; other site
364254001094	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
364254001095	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
364254001096	active site
364254001097	catalytic tetrad [active]
364254001098	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
364254001099	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
364254001100	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001101	Walker A/P-loop; other site
364254001102	ATP binding site [chemical binding]; other site
364254001103	Q-loop/lid; other site
364254001104	ABC transporter signature motif; other site
364254001105	Walker B; other site
364254001106	D-loop; other site
364254001107	H-loop/switch region; other site
364254001108	ABC transporter; Region: ABC_tran_2; pfam12848
364254001109	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254001110	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254001111	Helix-turn-helix domains; Region: HTH; cl00088
364254001112	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
364254001113	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
364254001114	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
364254001115	YibE/F-like protein; Region: YibE_F; cl02259
364254001116	YibE/F-like protein; Region: YibE_F; cl02259
364254001117	stage V sporulation protein K; Region: spore_V_K; TIGR02881
364254001118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254001119	Walker A motif; other site
364254001120	ATP binding site [chemical binding]; other site
364254001121	Walker B motif; other site
364254001122	arginine finger; other site
364254001123	OsmC-like protein; Region: OsmC; cl00767
364254001124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001125	Family description; Region: UvrD_C_2; cl15862
364254001126	Protein of unknown function, DUF606; Region: DUF606; cl01273
364254001127	sugar phosphate phosphatase; Provisional; Region: PRK10513
364254001128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254001129	active site
364254001130	motif I; other site
364254001131	motif II; other site
364254001132	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254001133	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
364254001134	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
364254001135	Zn2+ binding site [ion binding]; other site
364254001136	Mg2+ binding site [ion binding]; other site
364254001137	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
364254001138	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
364254001139	catalytic triad [active]
364254001140	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
364254001141	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
364254001142	CTP synthetase; Validated; Region: pyrG; PRK05380
364254001143	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
364254001144	Catalytic site [active]
364254001145	active site
364254001146	UTP binding site [chemical binding]; other site
364254001147	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
364254001148	active site
364254001149	putative oxyanion hole; other site
364254001150	catalytic triad [active]
364254001151	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
364254001152	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
364254001153	hinge; other site
364254001154	active site
364254001155	transcription termination factor Rho; Provisional; Region: rho; PRK09376
364254001156	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
364254001157	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
364254001158	RNA binding site [nucleotide binding]; other site
364254001159	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
364254001160	multimer interface [polypeptide binding]; other site
364254001161	Walker A motif; other site
364254001162	ATP binding site [chemical binding]; other site
364254001163	Walker B motif; other site
364254001164	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
364254001165	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
364254001166	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
364254001167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001168	DEAD_2; Region: DEAD_2; pfam06733
364254001169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001170	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
364254001171	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
364254001172	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
364254001173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
364254001174	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
364254001175	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
364254001176	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
364254001177	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254001178	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
364254001179	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
364254001180	DEAD-like helicases superfamily; Region: DEXDc; smart00487
364254001181	ATP binding site [chemical binding]; other site
364254001182	Mg++ binding site [ion binding]; other site
364254001183	motif III; other site
364254001184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254001185	nucleotide binding region [chemical binding]; other site
364254001186	Hef nuclease; Provisional; Region: PRK13766
364254001187	ATP-binding site [chemical binding]; other site
364254001188	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
364254001189	alanine racemase; Reviewed; Region: alr; PRK00053
364254001190	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
364254001191	active site
364254001192	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
364254001193	dimer interface [polypeptide binding]; other site
364254001194	substrate binding site [chemical binding]; other site
364254001195	catalytic residues [active]
364254001196	PemK-like protein; Region: PemK; cl00995
364254001197	Protein of unknown function DUF72; Region: DUF72; cl00777
364254001198	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
364254001199	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
364254001200	active site
364254001201	catalytic residues [active]
364254001202	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
364254001203	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
364254001204	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
364254001205	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
364254001206	RecX family; Region: RecX; cl00936
364254001207	TRAM domain; Region: TRAM; cl01282
364254001208	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
364254001209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254001210	S-adenosylmethionine binding site [chemical binding]; other site
364254001211	Protein of unknown function (DUF402); Region: DUF402; cl00979
364254001212	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
364254001213	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
364254001214	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
364254001215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254001216	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
364254001217	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
364254001218	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001219	Walker A/P-loop; other site
364254001220	ATP binding site [chemical binding]; other site
364254001221	Q-loop/lid; other site
364254001222	ABC transporter signature motif; other site
364254001223	Walker B; other site
364254001224	D-loop; other site
364254001225	H-loop/switch region; other site
364254001226	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254001227	putative peptidoglycan binding site; other site
364254001228	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
364254001229	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
364254001230	G1 box; other site
364254001231	putative GEF interaction site [polypeptide binding]; other site
364254001232	GTP/Mg2+ binding site [chemical binding]; other site
364254001233	Switch I region; other site
364254001234	G2 box; other site
364254001235	G3 box; other site
364254001236	Switch II region; other site
364254001237	G4 box; other site
364254001238	G5 box; other site
364254001239	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
364254001240	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
364254001241	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
364254001242	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
364254001243	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
364254001244	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
364254001245	Similar to sugar transport protein; nonfunctional due to insertion of IS element
364254001246	Similar to transposase ISLasa4d, ISL3 family; nonfunctional due to interrupting stop codon
364254001247	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
364254001248	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
364254001249	DNA binding site [nucleotide binding]
364254001250	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
364254001251	putative ligand binding site [chemical binding]; other site
364254001252	putative dimerization interface [polypeptide binding]; other site
364254001253	galactokinase; Provisional; Region: PRK05322
364254001254	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
364254001255	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
364254001256	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
364254001257	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
364254001258	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
364254001259	NAD binding site [chemical binding]; other site
364254001260	homodimer interface [polypeptide binding]; other site
364254001261	active site
364254001262	substrate binding site [chemical binding]; other site
364254001263	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
364254001264	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
364254001265	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
364254001266	Similar to alpha-galactosidase; nonfunctional due to interrupting stop codon
364254001267	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001268	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
364254001269	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
364254001270	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
364254001271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254001272	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
364254001273	Walker A motif; other site
364254001274	ATP binding site [chemical binding]; other site
364254001275	Walker B motif; other site
364254001276	arginine finger; other site
364254001277	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
364254001278	UvrB/uvrC motif; Region: UVR; pfam02151
364254001279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254001280	Walker A motif; other site
364254001281	ATP binding site [chemical binding]; other site
364254001282	Walker B motif; other site
364254001283	arginine finger; other site
364254001284	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254001285	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
364254001286	dimerization domain swap beta strand [polypeptide binding]; other site
364254001287	regulatory protein interface [polypeptide binding]; other site
364254001288	active site
364254001289	regulatory phosphorylation site [posttranslational modification]; other site
364254001290	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
364254001291	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
364254001292	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
364254001293	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
364254001294	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254001295	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
364254001296	putative ADP-binding pocket [chemical binding]; other site
364254001297	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
364254001298	Predicted integral membrane protein [Function unknown]; Region: COG0392
364254001299	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
364254001300	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
364254001301	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
364254001302	Sulfatase; Region: Sulfatase; cl10460
364254001303	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
364254001304	active site
364254001305	metal-binding site [ion binding]
364254001306	nucleotide-binding site [chemical binding]; other site
364254001307	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
364254001308	Competence protein CoiA-like family; Region: CoiA; cl11541
364254001309	oligoendopeptidase F; Region: pepF; TIGR00181
364254001310	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
364254001311	active site
364254001312	Zn binding site [ion binding]; other site
364254001313	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
364254001314	Thioredoxin; Region: Thioredoxin_5; pfam13743
364254001315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254001316	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
364254001317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254001318	dimer interface [polypeptide binding]; other site
364254001319	conserved gate region; other site
364254001320	putative PBP binding loops; other site
364254001321	ABC-ATPase subunit interface; other site
364254001322	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
364254001323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254001324	dimer interface [polypeptide binding]; other site
364254001325	conserved gate region; other site
364254001326	putative PBP binding loops; other site
364254001327	ABC-ATPase subunit interface; other site
364254001328	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
364254001329	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
364254001330	Walker A/P-loop; other site
364254001331	ATP binding site [chemical binding]; other site
364254001332	Q-loop/lid; other site
364254001333	ABC transporter signature motif; other site
364254001334	Walker B; other site
364254001335	D-loop; other site
364254001336	H-loop/switch region; other site
364254001337	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
364254001338	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
364254001339	Walker A/P-loop; other site
364254001340	ATP binding site [chemical binding]; other site
364254001341	Q-loop/lid; other site
364254001342	ABC transporter signature motif; other site
364254001343	Walker B; other site
364254001344	D-loop; other site
364254001345	H-loop/switch region; other site
364254001346	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
364254001347	PhoU domain; Region: PhoU; pfam01895
364254001348	PhoU domain; Region: PhoU; pfam01895
364254001349	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
364254001350	hypothetical protein; Provisional; Region: PRK08185
364254001351	intersubunit interface [polypeptide binding]; other site
364254001352	active site
364254001353	zinc binding site [ion binding]; other site
364254001354	Na+ binding site [ion binding]; other site
364254001355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254001356	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254001357	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
364254001358	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
364254001359	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
364254001360	Haemolysin-III related; Region: HlyIII; cl03831
364254001361	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
364254001362	dimerization interface [polypeptide binding]; other site
364254001363	putative DNA binding site [nucleotide binding]; other site
364254001364	putative Zn2+ binding site [ion binding]; other site
364254001365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254001366	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254001367	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
364254001368	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
364254001369	RNA/DNA hybrid binding site [nucleotide binding]; other site
364254001370	active site
364254001371	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
364254001372	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
364254001373	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
364254001374	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
364254001375	active site
364254001376	catabolite control protein A; Region: ccpA; TIGR01481
364254001377	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
364254001378	DNA binding site [nucleotide binding]
364254001379	domain linker motif; other site
364254001380	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
364254001381	dimerization interface [polypeptide binding]; other site
364254001382	effector binding site; other site
364254001383	VanZ like family; Region: VanZ; cl01971
364254001384	Transcriptional regulator; Region: Transcrip_reg; cl00361
364254001385	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
364254001386	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
364254001387	substrate binding site [chemical binding]; other site
364254001388	dimer interface [polypeptide binding]; other site
364254001389	ATP binding site [chemical binding]; other site
364254001390	Type II/IV secretion system protein; Region: T2SE; pfam00437
364254001391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001392	Walker A motif; other site
364254001393	ATP binding site [chemical binding]; other site
364254001394	Walker B motif; other site
364254001395	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
364254001396	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
364254001397	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
364254001398	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
364254001399	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
364254001400	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
364254001401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254001402	Similar to transposase ISLasa4g, ISL3 family; nonfunctional due to interrupting stop codon
364254001403	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
364254001404	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
364254001405	putative active site [active]
364254001406	putative metal binding site [ion binding]; other site
364254001407	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
364254001408	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
364254001409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254001410	active site
364254001411	motif I; other site
364254001412	motif II; other site
364254001413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254001414	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
364254001415	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
364254001416	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
364254001417	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254001418	general stress protein 13; Validated; Region: PRK08059
364254001419	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
364254001420	RNA binding site [nucleotide binding]; other site
364254001421	S-adenosylmethionine synthetase; Validated; Region: PRK05250
364254001422	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
364254001423	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
364254001424	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
364254001425	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
364254001426	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
364254001427	HIGH motif; other site
364254001428	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
364254001429	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
364254001430	active site
364254001431	KMSKS motif; other site
364254001432	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
364254001433	tRNA binding surface [nucleotide binding]; other site
364254001434	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
364254001435	MatE; Region: MatE; cl10513
364254001436	stage V sporulation protein B; Region: spore_V_B; TIGR02900
364254001437	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
364254001438	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254001439	RNA binding surface [nucleotide binding]; other site
364254001440	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
364254001441	active site
364254001442	uracil binding [chemical binding]; other site
364254001443	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
364254001444	putative substrate binding site [chemical binding]; other site
364254001445	putative ATP binding site [chemical binding]; other site
364254001446	dipeptidase PepV; Reviewed; Region: PRK07318
364254001447	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
364254001448	active site
364254001449	metal binding site [ion binding]; metal-binding site
364254001450	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
364254001451	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
364254001452	Helix-turn-helix domains; Region: HTH; cl00088
364254001453	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
364254001454	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
364254001455	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
364254001456	dimer interface [polypeptide binding]; other site
364254001457	active site
364254001458	CoA binding pocket [chemical binding]; other site
364254001459	Acyl transferase domain; Region: Acyl_transf_1; cl08282
364254001460	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
364254001461	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
364254001462	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
364254001463	NAD(P) binding site [chemical binding]; other site
364254001464	homotetramer interface [polypeptide binding]; other site
364254001465	homodimer interface [polypeptide binding]; other site
364254001466	active site
364254001467	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
364254001468	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
364254001469	dimer interface [polypeptide binding]; other site
364254001470	active site
364254001471	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
364254001472	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
364254001473	carboxyltransferase (CT) interaction site; other site
364254001474	biotinylation site [posttranslational modification]; other site
364254001475	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
364254001476	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
364254001477	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
364254001478	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254001479	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
364254001480	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
364254001481	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
364254001482	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
364254001483	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
364254001484	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
364254001485	NAD binding site [chemical binding]; other site
364254001486	homotetramer interface [polypeptide binding]; other site
364254001487	homodimer interface [polypeptide binding]; other site
364254001488	substrate binding site [chemical binding]; other site
364254001489	active site
364254001490	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
364254001491	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
364254001492	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
364254001493	Similar to transposase ISLasa4h, ISL3 family; nonfunctional due to interrupting stop codon
364254001494	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
364254001495	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
364254001496	active site
364254001497	dimer interface [polypeptide binding]; other site
364254001498	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
364254001499	dimer interface [polypeptide binding]; other site
364254001500	active site
364254001501	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
364254001502	Sulfatase; Region: Sulfatase; cl10460
364254001503	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
364254001504	amphipathic channel; other site
364254001505	Asn-Pro-Ala signature motifs; other site
364254001506	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
364254001507	FOG: CBS domain [General function prediction only]; Region: COG0517
364254001508	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
364254001509	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
364254001510	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
364254001511	active site
364254001512	trimer interface [polypeptide binding]; other site
364254001513	substrate binding site [chemical binding]; other site
364254001514	CoA binding site [chemical binding]; other site
364254001515	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
364254001516	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
364254001517	metal binding site [ion binding]; metal-binding site
364254001518	putative dimer interface [polypeptide binding]; other site
364254001519	Mechanosensitive ion channel; Region: MS_channel; pfam00924
364254001520	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
364254001521	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
364254001522	ligand binding site [chemical binding]; other site
364254001523	flexible hinge region; other site
364254001524	Helix-turn-helix domains; Region: HTH; cl00088
364254001525	Transglycosylase; Region: Transgly; cl07896
364254001526	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
364254001527	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254001528	Protein of unknown function (DUF964); Region: DUF964; cl01483
364254001529	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
364254001530	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
364254001531	generic binding surface II; other site
364254001532	generic binding surface I; other site
364254001533	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
364254001534	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254001535	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
364254001536	SurA N-terminal domain; Region: SurA_N_3; cl07813
364254001537	PPIC-type PPIASE domain; Region: Rotamase; cl08278
364254001538	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
364254001539	HIT family signature motif; other site
364254001540	catalytic residue [active]
364254001541	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
364254001542	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
364254001543	Walker A/P-loop; other site
364254001544	ATP binding site [chemical binding]; other site
364254001545	Q-loop/lid; other site
364254001546	ABC transporter signature motif; other site
364254001547	Walker B; other site
364254001548	D-loop; other site
364254001549	H-loop/switch region; other site
364254001550	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
364254001551	Phosphotransferase enzyme family; Region: APH; pfam01636
364254001552	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
364254001553	active site
364254001554	ATP binding site [chemical binding]; other site
364254001555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254001556	S-adenosylmethionine binding site [chemical binding]; other site
364254001557	Predicted small secreted protein [Function unknown]; Region: COG5584
364254001558	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
364254001559	catalytic residues [active]
364254001560	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
364254001561	putative tRNA-binding site [nucleotide binding]; other site
364254001562	Similar to cell division protein FtsK; nonfunctional due to truncation; Nonfunctional due to truncation
364254001563	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
364254001564	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
364254001565	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254001566	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
364254001567	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
364254001568	dimer interaction site [polypeptide binding]; other site
364254001569	substrate-binding tunnel; other site
364254001570	active site
364254001571	catalytic site [active]
364254001572	substrate binding site [chemical binding]; other site
364254001573	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
364254001574	DNA polymerase I; Provisional; Region: PRK05755
364254001575	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
364254001576	active site
364254001577	metal binding site 1 [ion binding]; metal-binding site
364254001578	putative 5' ssDNA interaction site; other site
364254001579	metal binding site 3; metal-binding site
364254001580	metal binding site 2 [ion binding]; metal-binding site
364254001581	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
364254001582	putative DNA binding site [nucleotide binding]; other site
364254001583	putative metal binding site [ion binding]; other site
364254001584	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
364254001585	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
364254001586	active site
364254001587	DNA binding site [nucleotide binding]
364254001588	catalytic site [active]
364254001589	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
364254001590	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
364254001591	DNA binding site [nucleotide binding]
364254001592	catalytic residue [active]
364254001593	H2TH interface [polypeptide binding]; other site
364254001594	putative catalytic residues [active]
364254001595	turnover-facilitating residue; other site
364254001596	intercalation triad [nucleotide binding]; other site
364254001597	8OG recognition residue [nucleotide binding]; other site
364254001598	putative reading head residues; other site
364254001599	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
364254001600	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
364254001601	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
364254001602	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
364254001603	CoA-binding site [chemical binding]; other site
364254001604	ATP-binding [chemical binding]; other site
364254001605	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
364254001606	ATP cone domain; Region: ATP-cone; pfam03477
364254001607	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
364254001608	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
364254001609	primosomal protein DnaI; Reviewed; Region: PRK08939
364254001610	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
364254001611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254001612	Walker A motif; other site
364254001613	ATP binding site [chemical binding]; other site
364254001614	Walker B motif; other site
364254001615	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
364254001616	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
364254001617	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
364254001618	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
364254001619	active site
364254001620	dimer interface [polypeptide binding]; other site
364254001621	motif 1; other site
364254001622	motif 2; other site
364254001623	motif 3; other site
364254001624	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
364254001625	anticodon binding site; other site
364254001626	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
364254001627	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
364254001628	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
364254001629	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
364254001630	ribosomal protein L20; Region: rpl20; CHL00068
364254001631	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
364254001632	23S rRNA binding site [nucleotide binding]; other site
364254001633	L21 binding site [polypeptide binding]; other site
364254001634	L13 binding site [polypeptide binding]; other site
364254001635	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254001636	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254001637	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
364254001638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254001639	active site
364254001640	motif I; other site
364254001641	motif II; other site
364254001642	GTPase YqeH; Provisional; Region: PRK13796
364254001643	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
364254001644	GTP/Mg2+ binding site [chemical binding]; other site
364254001645	G4 box; other site
364254001646	G5 box; other site
364254001647	G1 box; other site
364254001648	Switch I region; other site
364254001649	G2 box; other site
364254001650	G3 box; other site
364254001651	Switch II region; other site
364254001652	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
364254001653	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
364254001654	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
364254001655	active site
364254001656	(T/H)XGH motif; other site
364254001657	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
364254001658	Zn2+ binding site [ion binding]; other site
364254001659	Mg2+ binding site [ion binding]; other site
364254001660	Oligomerisation domain; Region: Oligomerisation; cl00519
364254001661	Similar to methyltransferase; nonfunctional due to frameshift
364254001662	hypothetical protein; Provisional; Region: PRK13670
364254001663	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
364254001664	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
364254001665	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
364254001666	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
364254001667	putative acyl-acceptor binding pocket; other site
364254001668	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
364254001669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254001670	S-adenosylmethionine binding site [chemical binding]; other site
364254001671	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
364254001672	GIY-YIG motif/motif A; other site
364254001673	putative active site [active]
364254001674	putative metal binding site [ion binding]; other site
364254001675	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
364254001676	rRNA interaction site [nucleotide binding]; other site
364254001677	S8 interaction site; other site
364254001678	putative laminin-1 binding site; other site
364254001679	elongation factor Ts; Provisional; Region: tsf; PRK09377
364254001680	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
364254001681	Elongation factor TS; Region: EF_TS; pfam00889
364254001682	Elongation factor TS; Region: EF_TS; pfam00889
364254001683	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
364254001684	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
364254001685	Substrate-binding site [chemical binding]; other site
364254001686	Substrate specificity [chemical binding]; other site
364254001687	AIR carboxylase; Region: AIRC; cl00310
364254001688	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
364254001689	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254001690	adenylosuccinate lyase; Provisional; Region: PRK07492
364254001691	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
364254001692	tetramer interface [polypeptide binding]; other site
364254001693	active site
364254001694	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
364254001695	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
364254001696	active site
364254001697	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
364254001698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254001699	active site
364254001700	phosphorylation site [posttranslational modification]
364254001701	intermolecular recognition site; other site
364254001702	dimerization interface [polypeptide binding]; other site
364254001703	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
364254001704	DNA binding site [nucleotide binding]
364254001705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
364254001706	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
364254001707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
364254001708	dimer interface [polypeptide binding]; other site
364254001709	phosphorylation site [posttranslational modification]
364254001710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254001711	ATP binding site [chemical binding]; other site
364254001712	Mg2+ binding site [ion binding]; other site
364254001713	G-X-G motif; other site
364254001714	OxaA-like protein precursor; Provisional; Region: PRK02463
364254001715	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
364254001716	Acylphosphatase; Region: Acylphosphatase; cl00551
364254001717	'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827
364254001718	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
364254001719	dimer interface [polypeptide binding]; other site
364254001720	active site
364254001721	elongation factor P; Validated; Region: PRK00529
364254001722	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
364254001723	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
364254001724	RNA binding site [nucleotide binding]; other site
364254001725	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
364254001726	RNA binding site [nucleotide binding]; other site
364254001727	Asp23 family; Region: Asp23; cl00574
364254001728	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
364254001729	putative RNA binding site [nucleotide binding]; other site
364254001730	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
364254001731	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
364254001732	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
364254001733	homodimer interface [polypeptide binding]; other site
364254001734	NADP binding site [chemical binding]; other site
364254001735	substrate binding site [chemical binding]; other site
364254001736	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
364254001737	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
364254001738	generic binding surface II; other site
364254001739	generic binding surface I; other site
364254001740	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
364254001741	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
364254001742	substrate binding pocket [chemical binding]; other site
364254001743	chain length determination region; other site
364254001744	substrate-Mg2+ binding site; other site
364254001745	catalytic residues [active]
364254001746	aspartate-rich region 1; other site
364254001747	active site lid residues [active]
364254001748	aspartate-rich region 2; other site
364254001749	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
364254001750	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
364254001751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
364254001752	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
364254001753	arginine repressor; Provisional; Region: PRK04280
364254001754	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
364254001755	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
364254001756	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
364254001757	Walker A/P-loop; other site
364254001758	ATP binding site [chemical binding]; other site
364254001759	Q-loop/lid; other site
364254001760	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
364254001761	ABC transporter signature motif; other site
364254001762	Walker B; other site
364254001763	D-loop; other site
364254001764	H-loop/switch region; other site
364254001765	LexA repressor; Validated; Region: PRK00215
364254001766	Helix-turn-helix domains; Region: HTH; cl00088
364254001767	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
364254001768	Catalytic site [active]
364254001769	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
364254001770	Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536
364254001771	Predicted GTPase [General function prediction only]; Region: COG0218
364254001772	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
364254001773	G1 box; other site
364254001774	GTP/Mg2+ binding site [chemical binding]; other site
364254001775	Switch I region; other site
364254001776	G2 box; other site
364254001777	G3 box; other site
364254001778	Switch II region; other site
364254001779	G4 box; other site
364254001780	G5 box; other site
364254001781	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
364254001782	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
364254001783	Helix-turn-helix domains; Region: HTH; cl00088
364254001784	putative transposase OrfB; Reviewed; Region: PHA02517
364254001785	HTH-like domain; Region: HTH_21; pfam13276
364254001786	Integrase core domain; Region: rve; cl01316
364254001787	Integrase core domain; Region: rve_3; cl15866
364254001788	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
364254001789	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
364254001790	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
364254001791	Rhomboid family; Region: Rhomboid; cl11446
364254001792	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
364254001793	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
364254001794	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
364254001795	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
364254001796	active site residue [active]
364254001797	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001798	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
364254001799	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
364254001800	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
364254001801	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
364254001802	DNA binding residues [nucleotide binding]
364254001803	putative dimer interface [polypeptide binding]; other site
364254001804	glutamine synthetase, type I; Region: GlnA; TIGR00653
364254001805	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
364254001806	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
364254001807	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
364254001808	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
364254001809	DNA binding site [nucleotide binding]
364254001810	active site
364254001811	Domain of unknown function (DUF956); Region: DUF956; cl01917
364254001812	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
364254001813	putative nucleotide binding site [chemical binding]; other site
364254001814	uridine monophosphate binding site [chemical binding]; other site
364254001815	homohexameric interface [polypeptide binding]; other site
364254001816	ribosome recycling factor; Reviewed; Region: frr; PRK00083
364254001817	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
364254001818	hinge region; other site
364254001819	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
364254001820	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
364254001821	catalytic residue [active]
364254001822	putative FPP diphosphate  binding site; other site
364254001823	putative FPP binding hydrophobic cleft; other site
364254001824	dimer interface [polypeptide binding]; other site
364254001825	putative IPP diphosphate binding site; other site
364254001826	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
364254001827	RIP metalloprotease RseP; Region: TIGR00054
364254001828	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
364254001829	active site
364254001830	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
364254001831	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
364254001832	protein binding site [polypeptide binding]; other site
364254001833	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
364254001834	putative substrate binding region [chemical binding]; other site
364254001835	prolyl-tRNA synthetase; Provisional; Region: PRK09194
364254001836	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
364254001837	dimer interface [polypeptide binding]; other site
364254001838	motif 1; other site
364254001839	active site
364254001840	motif 2; other site
364254001841	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
364254001842	putative deacylase active site [active]
364254001843	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
364254001844	active site
364254001845	motif 3; other site
364254001846	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
364254001847	anticodon binding site; other site
364254001848	DNA polymerase III PolC; Validated; Region: polC; PRK00448
364254001849	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
364254001850	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
364254001851	generic binding surface II; other site
364254001852	generic binding surface I; other site
364254001853	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
364254001854	active site
364254001855	catalytic site [active]
364254001856	substrate binding site [chemical binding]; other site
364254001857	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
364254001858	ribosome maturation protein RimP; Reviewed; Region: PRK00092
364254001859	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
364254001860	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
364254001861	Sm1 motif; other site
364254001862	predicted subunit interaction site [polypeptide binding]; other site
364254001863	RNA binding pocket [nucleotide binding]; other site
364254001864	Sm2 motif; other site
364254001865	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
364254001866	NusA N-terminal domain; Region: NusA_N; pfam08529
364254001867	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
364254001868	RNA binding site [nucleotide binding]; other site
364254001869	homodimer interface [polypeptide binding]; other site
364254001870	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
364254001871	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
364254001872	G-X-X-G motif; other site
364254001873	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
364254001874	putative RNA binding cleft [nucleotide binding]; other site
364254001875	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
364254001876	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
364254001877	translation initiation factor IF-2; Region: IF-2; TIGR00487
364254001878	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
364254001879	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
364254001880	G1 box; other site
364254001881	putative GEF interaction site [polypeptide binding]; other site
364254001882	GTP/Mg2+ binding site [chemical binding]; other site
364254001883	Switch I region; other site
364254001884	G2 box; other site
364254001885	G3 box; other site
364254001886	Switch II region; other site
364254001887	G4 box; other site
364254001888	G5 box; other site
364254001889	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
364254001890	Translation-initiation factor 2; Region: IF-2; pfam11987
364254001891	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
364254001892	Ribosome-binding factor A; Region: RBFA; cl00542
364254001893	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
364254001894	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
364254001895	RNA binding site [nucleotide binding]; other site
364254001896	active site
364254001897	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
364254001898	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
364254001899	active site
364254001900	Riboflavin kinase; Region: Flavokinase; cl03312
364254001901	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
364254001902	HrcA protein C terminal domain; Region: HrcA; pfam01628
364254001903	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
364254001904	dimer interface [polypeptide binding]; other site
364254001905	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
364254001906	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
364254001907	StbA protein; Region: StbA; pfam06406
364254001908	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
364254001909	chaperone protein DnaJ; Provisional; Region: PRK14276
364254001910	HSP70 interaction site [polypeptide binding]; other site
364254001911	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
364254001912	substrate binding site [polypeptide binding]; other site
364254001913	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
364254001914	Zn binding sites [ion binding]; other site
364254001915	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
364254001916	substrate binding site [polypeptide binding]; other site
364254001917	dimer interface [polypeptide binding]; other site
364254001918	GTP-binding protein LepA; Provisional; Region: PRK05433
364254001919	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
364254001920	G1 box; other site
364254001921	putative GEF interaction site [polypeptide binding]; other site
364254001922	GTP/Mg2+ binding site [chemical binding]; other site
364254001923	Switch I region; other site
364254001924	G2 box; other site
364254001925	G3 box; other site
364254001926	Switch II region; other site
364254001927	G4 box; other site
364254001928	G5 box; other site
364254001929	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
364254001930	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
364254001931	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
364254001932	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254001933	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254001934	substrate binding pocket [chemical binding]; other site
364254001935	membrane-bound complex binding site; other site
364254001936	hinge residues; other site
364254001937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254001938	dimer interface [polypeptide binding]; other site
364254001939	conserved gate region; other site
364254001940	putative PBP binding loops; other site
364254001941	ABC-ATPase subunit interface; other site
364254001942	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
364254001943	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
364254001944	Walker A/P-loop; other site
364254001945	ATP binding site [chemical binding]; other site
364254001946	Q-loop/lid; other site
364254001947	ABC transporter signature motif; other site
364254001948	Walker B; other site
364254001949	D-loop; other site
364254001950	H-loop/switch region; other site
364254001951	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254001952	putative transposase OrfB; Reviewed; Region: PHA02517
364254001953	HTH-like domain; Region: HTH_21; pfam13276
364254001954	Integrase core domain; Region: rve; cl01316
364254001955	Integrase core domain; Region: rve_3; cl15866
364254001956	Helix-turn-helix domains; Region: HTH; cl00088
364254001957	Helix-turn-helix domains; Region: HTH; cl00088
364254001958	Helix-turn-helix domains; Region: HTH; cl00088
364254001959	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
364254001960	catalytic triad [active]
364254001961	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
364254001962	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254001963	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
364254001964	thymidine kinase; Provisional; Region: PRK04296
364254001965	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254001966	ATP binding site [chemical binding]; other site
364254001967	Walker A motif; other site
364254001968	Walker B motif; other site
364254001969	peptide chain release factor 1; Validated; Region: prfA; PRK00591
364254001970	RF-1 domain; Region: RF-1; cl02875
364254001971	RF-1 domain; Region: RF-1; cl02875
364254001972	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
364254001973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254001974	S-adenosylmethionine binding site [chemical binding]; other site
364254001975	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
364254001976	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
364254001977	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254001978	active site
364254001979	ATP synthase A chain; Region: ATP-synt_A; cl00413
364254001980	ATP synthase subunit C; Region: ATP-synt_C; cl00466
364254001981	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
364254001982	Plant ATP synthase F0; Region: YMF19; cl07975
364254001983	Plant ATP synthase F0; Region: YMF19; cl07975
364254001984	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
364254001985	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
364254001986	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
364254001987	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
364254001988	beta subunit interaction interface [polypeptide binding]; other site
364254001989	Walker A motif; other site
364254001990	ATP binding site [chemical binding]; other site
364254001991	Walker B motif; other site
364254001992	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
364254001993	ATP synthase; Region: ATP-synt; cl00365
364254001994	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
364254001995	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
364254001996	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
364254001997	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
364254001998	alpha subunit interaction interface [polypeptide binding]; other site
364254001999	Walker A motif; other site
364254002000	ATP binding site [chemical binding]; other site
364254002001	Walker B motif; other site
364254002002	inhibitor binding site; inhibition site
364254002003	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
364254002004	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
364254002005	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
364254002006	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
364254002007	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
364254002008	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
364254002009	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
364254002010	hinge; other site
364254002011	active site
364254002012	rod shape-determining protein MreB; Provisional; Region: PRK13930
364254002013	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
364254002014	ATP binding site [chemical binding]; other site
364254002015	Cell division protein FtsA; Region: FtsA; cl11496
364254002016	Haemolytic domain; Region: Haemolytic; cl00506
364254002017	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
364254002018	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
364254002019	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
364254002020	ArsC family; Region: ArsC; pfam03960
364254002021	putative ArsC-like catalytic residues; other site
364254002022	putative TRX-like catalytic residues [active]
364254002023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254002024	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254002025	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
364254002026	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
364254002027	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
364254002028	catalytic site [active]
364254002029	G-X2-G-X-G-K; other site
364254002030	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
364254002031	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
364254002032	Flavoprotein; Region: Flavoprotein; cl08021
364254002033	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
364254002034	primosome assembly protein PriA; Validated; Region: PRK05580
364254002035	primosome assembly protein PriA; Validated; Region: PRK05580
364254002036	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254002037	ATP binding site [chemical binding]; other site
364254002038	putative Mg++ binding site [ion binding]; other site
364254002039	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254002040	nucleotide binding region [chemical binding]; other site
364254002041	ATP-binding site [chemical binding]; other site
364254002042	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
364254002043	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
364254002044	putative active site [active]
364254002045	substrate binding site [chemical binding]; other site
364254002046	putative cosubstrate binding site; other site
364254002047	catalytic site [active]
364254002048	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
364254002049	substrate binding site [chemical binding]; other site
364254002050	16S rRNA methyltransferase B; Provisional; Region: PRK14902
364254002051	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
364254002052	putative RNA binding site [nucleotide binding]; other site
364254002053	LytB protein; Region: LYTB; cl00507
364254002054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254002055	S-adenosylmethionine binding site [chemical binding]; other site
364254002056	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
364254002057	active site
364254002058	Similar to serine/threonine protein kinase 2.7.1.37); nonfunctional due to truncation
364254002059	GTPase RsgA; Reviewed; Region: PRK00098
364254002060	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
364254002061	RNA binding site [nucleotide binding]; other site
364254002062	homodimer interface [polypeptide binding]; other site
364254002063	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
364254002064	GTPase/Zn-binding domain interface [polypeptide binding]; other site
364254002065	GTP/Mg2+ binding site [chemical binding]; other site
364254002066	G4 box; other site
364254002067	G5 box; other site
364254002068	G1 box; other site
364254002069	Switch I region; other site
364254002070	G2 box; other site
364254002071	G3 box; other site
364254002072	Switch II region; other site
364254002073	Thiamine pyrophosphokinase; Region: TPK; cd07995
364254002074	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
364254002075	active site
364254002076	dimerization interface [polypeptide binding]; other site
364254002077	thiamine binding site [chemical binding]; other site
364254002078	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
364254002079	Asp23 family; Region: Asp23; cl00574
364254002080	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
364254002081	DAK2 domain; Region: Dak2; cl03685
364254002082	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
364254002083	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
364254002084	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
364254002085	generic binding surface II; other site
364254002086	ssDNA binding site; other site
364254002087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254002088	ATP binding site [chemical binding]; other site
364254002089	putative Mg++ binding site [ion binding]; other site
364254002090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254002091	nucleotide binding region [chemical binding]; other site
364254002092	ATP-binding site [chemical binding]; other site
364254002093	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
364254002094	Phosphopantetheine attachment site; Region: PP-binding; cl09936
364254002095	ribonuclease III; Reviewed; Region: rnc; PRK00102
364254002096	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
364254002097	dimerization interface [polypeptide binding]; other site
364254002098	active site
364254002099	metal binding site [ion binding]; metal-binding site
364254002100	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
364254002101	dsRNA binding site [nucleotide binding]; other site
364254002102	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
364254002103	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
364254002104	Walker A/P-loop; other site
364254002105	ATP binding site [chemical binding]; other site
364254002106	Q-loop/lid; other site
364254002107	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
364254002108	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
364254002109	Q-loop/lid; other site
364254002110	ABC transporter signature motif; other site
364254002111	Walker B; other site
364254002112	D-loop; other site
364254002113	H-loop/switch region; other site
364254002114	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
364254002115	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
364254002116	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
364254002117	P loop; other site
364254002118	GTP binding site [chemical binding]; other site
364254002119	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254002120	signal recognition particle protein; Provisional; Region: PRK10867
364254002121	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
364254002122	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
364254002123	P loop; other site
364254002124	GTP binding site [chemical binding]; other site
364254002125	Signal peptide binding domain; Region: SRP_SPB; pfam02978
364254002126	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
364254002127	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
364254002128	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
364254002129	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
364254002130	RimM N-terminal domain; Region: RimM; pfam01782
364254002131	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
364254002132	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
364254002133	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
364254002134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254002135	Coenzyme A binding pocket [chemical binding]; other site
364254002136	amino acid transporter; Region: 2A0306; TIGR00909
364254002137	Spore germination protein; Region: Spore_permease; cl15802
364254002138	Spore germination protein; Region: Spore_permease; cl15802
364254002139	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
364254002140	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
364254002141	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
364254002142	16S/18S rRNA binding site [nucleotide binding]; other site
364254002143	S13e-L30e interaction site [polypeptide binding]; other site
364254002144	25S rRNA binding site [nucleotide binding]; other site
364254002145	dihydrodipicolinate synthase; Region: dapA; TIGR00674
364254002146	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
364254002147	dimer interface [polypeptide binding]; other site
364254002148	active site
364254002149	catalytic residue [active]
364254002150	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
364254002151	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254002152	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
364254002153	elongation factor Tu; Reviewed; Region: PRK00049
364254002154	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
364254002155	G1 box; other site
364254002156	GEF interaction site [polypeptide binding]; other site
364254002157	GTP/Mg2+ binding site [chemical binding]; other site
364254002158	Switch I region; other site
364254002159	G2 box; other site
364254002160	G3 box; other site
364254002161	Switch II region; other site
364254002162	G4 box; other site
364254002163	G5 box; other site
364254002164	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
364254002165	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
364254002166	Antibiotic Binding Site [chemical binding]; other site
364254002167	trigger factor; Provisional; Region: tig; PRK01490
364254002168	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
364254002169	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
364254002170	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
364254002171	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
364254002172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254002173	Walker A motif; other site
364254002174	ATP binding site [chemical binding]; other site
364254002175	Walker B motif; other site
364254002176	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254002177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002178	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
364254002179	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
364254002180	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
364254002181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254002182	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
364254002183	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
364254002184	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
364254002185	active site
364254002186	catalytic residues [active]
364254002187	metal binding site [ion binding]; metal-binding site
364254002188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002189	substrate binding site [chemical binding]; other site
364254002190	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
364254002191	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
364254002192	active site
364254002193	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
364254002194	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
364254002195	G1 box; other site
364254002196	putative GEF interaction site [polypeptide binding]; other site
364254002197	GTP/Mg2+ binding site [chemical binding]; other site
364254002198	Switch I region; other site
364254002199	G2 box; other site
364254002200	G3 box; other site
364254002201	Switch II region; other site
364254002202	G4 box; other site
364254002203	G5 box; other site
364254002204	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
364254002205	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
364254002206	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
364254002207	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
364254002208	active pocket/dimerization site; other site
364254002209	active site
364254002210	phosphorylation site [posttranslational modification]
364254002211	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
364254002212	active site
364254002213	phosphorylation site [posttranslational modification]
364254002214	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
364254002215	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
364254002216	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
364254002217	pyruvate carboxylase; Reviewed; Region: PRK12999
364254002218	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
364254002219	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254002220	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
364254002221	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
364254002222	active site
364254002223	catalytic residues [active]
364254002224	metal binding site [ion binding]; metal-binding site
364254002225	homodimer binding site [polypeptide binding]; other site
364254002226	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
364254002227	carboxyltransferase (CT) interaction site; other site
364254002228	biotinylation site [posttranslational modification]; other site
364254002229	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
364254002230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
364254002231	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
364254002232	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
364254002233	active site
364254002234	(T/H)XGH motif; other site
364254002235	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
364254002236	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
364254002237	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
364254002238	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
364254002239	ATP binding site [chemical binding]; other site
364254002240	active site
364254002241	substrate binding site [chemical binding]; other site
364254002242	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
364254002243	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
364254002244	putative active site [active]
364254002245	catalytic triad [active]
364254002246	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
364254002247	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
364254002248	dimerization interface [polypeptide binding]; other site
364254002249	ATP binding site [chemical binding]; other site
364254002250	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
364254002251	dimerization interface [polypeptide binding]; other site
364254002252	ATP binding site [chemical binding]; other site
364254002253	amidophosphoribosyltransferase; Provisional; Region: PRK07272
364254002254	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
364254002255	active site
364254002256	tetramer interface [polypeptide binding]; other site
364254002257	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254002258	active site
364254002259	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
364254002260	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
364254002261	dimerization interface [polypeptide binding]; other site
364254002262	putative ATP binding site [chemical binding]; other site
364254002263	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
364254002264	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
364254002265	active site
364254002266	substrate binding site [chemical binding]; other site
364254002267	cosubstrate binding site; other site
364254002268	catalytic site [active]
364254002269	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
364254002270	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
364254002271	purine monophosphate binding site [chemical binding]; other site
364254002272	dimer interface [polypeptide binding]; other site
364254002273	putative catalytic residues [active]
364254002274	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
364254002275	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
364254002276	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
364254002277	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
364254002278	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254002279	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
364254002280	OpgC protein; Region: OpgC_C; cl00792
364254002281	Acyltransferase family; Region: Acyl_transf_3; pfam01757
364254002282	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
364254002283	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
364254002284	putative active site [active]
364254002285	catalytic site [active]
364254002286	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
364254002287	putative active site [active]
364254002288	catalytic site [active]
364254002289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
364254002290	Helix-turn-helix domains; Region: HTH; cl00088
364254002291	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
364254002292	dimerization interface [polypeptide binding]; other site
364254002293	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
364254002294	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254002295	active site
364254002296	motif I; other site
364254002297	motif II; other site
364254002298	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
364254002299	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
364254002300	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
364254002301	active site
364254002302	HIGH motif; other site
364254002303	KMSK motif region; other site
364254002304	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
364254002305	tRNA binding surface [nucleotide binding]; other site
364254002306	anticodon binding site; other site
364254002307	SLBB domain; Region: SLBB; pfam10531
364254002308	comEA protein; Region: comE; TIGR01259
364254002309	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
364254002310	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
364254002311	catalytic motif [active]
364254002312	Zn binding site [ion binding]; other site
364254002313	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
364254002314	Competence protein; Region: Competence; cl00471
364254002315	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254002316	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
364254002317	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
364254002318	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
364254002319	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
364254002320	homotetramer interface [polypeptide binding]; other site
364254002321	FMN binding site [chemical binding]; other site
364254002322	homodimer contacts [polypeptide binding]; other site
364254002323	putative active site [active]
364254002324	putative substrate binding site [chemical binding]; other site
364254002325	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
364254002326	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
364254002327	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
364254002328	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
364254002329	mevalonate kinase; Region: mevalon_kin; TIGR00549
364254002330	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
364254002331	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
364254002332	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
364254002333	active site
364254002334	catalytic site [active]
364254002335	substrate binding site [chemical binding]; other site
364254002336	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
364254002338	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
364254002339	aspartate aminotransferase; Provisional; Region: PRK05764
364254002340	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254002341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254002342	homodimer interface [polypeptide binding]; other site
364254002343	catalytic residue [active]
364254002344	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
364254002345	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
364254002346	putative dimer interface [polypeptide binding]; other site
364254002347	putative anticodon binding site; other site
364254002348	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
364254002349	homodimer interface [polypeptide binding]; other site
364254002350	motif 1; other site
364254002351	motif 2; other site
364254002352	active site
364254002353	motif 3; other site
364254002354	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
364254002355	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
364254002356	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
364254002357	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
364254002358	minor groove reading motif; other site
364254002359	helix-hairpin-helix signature motif; other site
364254002360	substrate binding pocket [chemical binding]; other site
364254002361	active site
364254002362	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
364254002363	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
364254002364	Uncharacterized conserved protein [Function unknown]; Region: COG1284
364254002365	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254002366	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254002367	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
364254002368	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
364254002369	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
364254002370	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
364254002371	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
364254002372	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
364254002373	active site
364254002374	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
364254002375	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
364254002376	GatB domain; Region: GatB_Yqey; cl11497
364254002377	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
364254002378	Uncharacterized conserved protein [Function unknown]; Region: COG1284
364254002379	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254002380	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254002381	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
364254002382	dihydrodipicolinate reductase; Provisional; Region: PRK00048
364254002383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002384	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
364254002385	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
364254002386	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
364254002387	active site
364254002388	NTP binding site [chemical binding]; other site
364254002389	metal binding triad [ion binding]; metal-binding site
364254002390	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
364254002391	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254002392	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
364254002393	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002394	Walker A/P-loop; other site
364254002395	ATP binding site [chemical binding]; other site
364254002396	Q-loop/lid; other site
364254002397	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254002398	ABC transporter signature motif; other site
364254002399	Walker B; other site
364254002400	D-loop; other site
364254002401	ABC transporter; Region: ABC_tran_2; pfam12848
364254002402	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254002403	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
364254002404	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
364254002405	dimerization interface [polypeptide binding]; other site
364254002406	active site
364254002407	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
364254002408	folate binding site [chemical binding]; other site
364254002409	NADP+ binding site [chemical binding]; other site
364254002410	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
364254002411	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
364254002412	active site
364254002413	catalytic tetrad [active]
364254002414	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
364254002415	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
364254002416	DNA binding residues [nucleotide binding]
364254002417	putative dimer interface [polypeptide binding]; other site
364254002418	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
364254002419	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
364254002420	active site
364254002421	catalytic tetrad [active]
364254002422	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
364254002423	active site
364254002424	catalytic triad [active]
364254002425	oxyanion hole [active]
364254002426	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
364254002427	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
364254002428	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
364254002429	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
364254002430	GTP/Mg2+ binding site [chemical binding]; other site
364254002431	G4 box; other site
364254002432	G5 box; other site
364254002433	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002434	G1 box; other site
364254002435	G1 box; other site
364254002436	GTP/Mg2+ binding site [chemical binding]; other site
364254002437	Switch I region; other site
364254002438	G2 box; other site
364254002439	G2 box; other site
364254002440	G3 box; other site
364254002441	G3 box; other site
364254002442	Switch II region; other site
364254002443	Switch II region; other site
364254002444	G4 box; other site
364254002445	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
364254002446	RNA/DNA hybrid binding site [nucleotide binding]; other site
364254002447	active site
364254002448	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
364254002449	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
364254002450	DNA topoisomerase I; Validated; Region: PRK05582
364254002451	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
364254002452	active site
364254002453	interdomain interaction site; other site
364254002454	putative metal-binding site [ion binding]; other site
364254002455	nucleotide binding site [chemical binding]; other site
364254002456	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
364254002457	domain I; other site
364254002458	DNA binding groove [nucleotide binding]
364254002459	phosphate binding site [ion binding]; other site
364254002460	domain II; other site
364254002461	domain III; other site
364254002462	nucleotide binding site [chemical binding]; other site
364254002463	catalytic site [active]
364254002464	domain IV; other site
364254002465	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
364254002466	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
364254002467	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
364254002468	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
364254002469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002470	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
364254002471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254002472	Helix-turn-helix domains; Region: HTH; cl00088
364254002473	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
364254002474	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
364254002475	Walker A/P-loop; other site
364254002476	ATP binding site [chemical binding]; other site
364254002477	Q-loop/lid; other site
364254002478	ABC transporter signature motif; other site
364254002479	Walker B; other site
364254002480	D-loop; other site
364254002481	H-loop/switch region; other site
364254002482	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
364254002483	ABC-2 type transporter; Region: ABC2_membrane; cl11417
364254002484	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254002485	catalytic core [active]
364254002486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
364254002487	TPR motif; other site
364254002488	Tetratricopeptide repeat; Region: TPR_12; pfam13424
364254002489	binding surface
364254002490	Tetratricopeptide repeat; Region: TPR_12; pfam13424
364254002491	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
364254002492	TPR motif; other site
364254002493	binding surface
364254002494	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
364254002495	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
364254002496	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002497	Family description; Region: UvrD_C_2; cl15862
364254002498	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
364254002499	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254002500	Int/Topo IB signature motif; other site
364254002501	Transposase IS200 like; Region: Y1_Tnp; cl00848
364254002502	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
364254002503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
364254002504	Probable transposase; Region: OrfB_IS605; pfam01385
364254002505	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
364254002506	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
364254002507	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
364254002508	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
364254002509	Domain of unknown function (DUF955); Region: DUF955; cl01076
364254002510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254002511	non-specific DNA binding site [nucleotide binding]; other site
364254002512	salt bridge; other site
364254002513	sequence-specific DNA binding site [nucleotide binding]; other site
364254002514	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
364254002515	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
364254002516	Domain of unknown function (DUF771); Region: DUF771; cl09962
364254002517	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
364254002518	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
364254002519	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002520	ATP binding site [chemical binding]; other site
364254002521	putative Mg++ binding site [ion binding]; other site
364254002522	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254002523	nucleotide binding region [chemical binding]; other site
364254002524	ATP-binding site [chemical binding]; other site
364254002525	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
364254002526	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
364254002527	AAA domain; Region: AAA_24; pfam13479
364254002528	Protein of unknown function (DUF669); Region: DUF669; pfam05037
364254002529	DNA polymerase type-B family; Region: POLBc; smart00486
364254002530	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023
364254002531	active site
364254002532	metal-binding site
364254002533	D5 N terminal like; Region: D5_N; cl07360
364254002534	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
364254002535	HNH endonuclease; Region: HNH_3; pfam13392
364254002536	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254002537	Int/Topo IB signature motif; other site
364254002538	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
364254002539	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
364254002540	Phage terminase, small subunit; Region: Terminase_4; cl01525
364254002541	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
364254002542	Phage Terminase; Region: Terminase_1; pfam03354
364254002543	Phage-related protein [Function unknown]; Region: COG4695; cl01923
364254002544	Phage portal protein; Region: Phage_portal; pfam04860
364254002545	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
364254002546	oligomer interface [polypeptide binding]; other site
364254002547	active site residues [active]
364254002548	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
364254002549	Phage capsid family; Region: Phage_capsid; pfam05065
364254002550	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
364254002551	oligomerization interface [polypeptide binding]; other site
364254002552	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
364254002553	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
364254002554	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
364254002555	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
364254002556	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
364254002557	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
364254002558	Phage tail protein; Region: Sipho_tail; pfam05709
364254002559	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
364254002560	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
364254002561	Peptidase family M23; Region: Peptidase_M23; pfam01551
364254002562	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
364254002563	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
364254002564	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
364254002565	active site
364254002566	competence damage-inducible protein A; Provisional; Region: PRK00549
364254002567	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
364254002568	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
364254002569	Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415
364254002570	active site
364254002571	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254002572	putative peptidoglycan binding site; other site
364254002573	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254002574	putative peptidoglycan binding site; other site
364254002575	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
364254002576	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
364254002577	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
364254002578	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254002579	Helix-turn-helix domains; Region: HTH; cl00088
364254002580	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
364254002581	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
364254002582	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
364254002583	dimer interface [polypeptide binding]; other site
364254002584	motif 1; other site
364254002585	active site
364254002586	motif 2; other site
364254002587	motif 3; other site
364254002588	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
364254002589	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
364254002590	putative tRNA-binding site [nucleotide binding]; other site
364254002591	B3/4 domain; Region: B3_4; cl11458
364254002592	tRNA synthetase B5 domain; Region: B5; cl08394
364254002593	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
364254002594	dimer interface [polypeptide binding]; other site
364254002595	motif 1; other site
364254002596	motif 3; other site
364254002597	motif 2; other site
364254002598	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
364254002599	YceG-like family; Region: YceG; pfam02618
364254002600	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
364254002601	dimerization interface [polypeptide binding]; other site
364254002602	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
364254002603	Sugar specificity; other site
364254002604	Pyrimidine base specificity; other site
364254002605	ATP-binding site [chemical binding]; other site
364254002606	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
364254002607	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
364254002608	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
364254002609	active site
364254002610	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
364254002611	Similar to ribosomal protein L11 methyltransferase nonfunctional due to deletion of 60 bp
364254002612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
364254002613	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
364254002614	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
364254002615	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254002616	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
364254002617	synthetase active site [active]
364254002618	NTP binding site [chemical binding]; other site
364254002619	metal binding site [ion binding]; metal-binding site
364254002620	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
364254002621	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
364254002622	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
364254002623	putative active site [active]
364254002624	dimerization interface [polypeptide binding]; other site
364254002625	putative tRNAtyr binding site [nucleotide binding]; other site
364254002626	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
364254002627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254002628	motif II; other site
364254002629	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
364254002630	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
364254002631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254002632	RNA binding surface [nucleotide binding]; other site
364254002633	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
364254002634	active site
364254002635	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254002636	active site
364254002637	uracil transporter; Provisional; Region: PRK10720
364254002638	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
364254002639	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
364254002640	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
364254002641	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
364254002642	catalytic site [active]
364254002643	subunit interface [polypeptide binding]; other site
364254002644	Similar to carbamoyl-phosphate synthase large chain; nonfunctional due to truncation
364254002645	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
364254002646	active site
364254002647	dimer interface [polypeptide binding]; other site
364254002648	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
364254002649	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254002650	active site
364254002651	Transcriptional regulator [Transcription]; Region: LysR; COG0583
364254002652	Helix-turn-helix domains; Region: HTH; cl00088
364254002653	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
364254002654	dimerization interface [polypeptide binding]; other site
364254002655	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
364254002656	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
364254002657	DHHA2 domain; Region: DHHA2; pfam02833
364254002658	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
364254002659	Helix-turn-helix domains; Region: HTH; cl00088
364254002660	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
364254002661	aromatic amino acid aminotransferase; Validated; Region: PRK07309
364254002662	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254002663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254002664	homodimer interface [polypeptide binding]; other site
364254002665	catalytic residue [active]
364254002666	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
364254002667	cell division protein GpsB; Provisional; Region: PRK14127
364254002668	DivIVA domain; Region: DivI1A_domain; TIGR03544
364254002669	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
364254002670	THUMP domain; Region: THUMP; cl12076
364254002671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002672	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
364254002673	RNA/DNA hybrid binding site [nucleotide binding]; other site
364254002674	active site
364254002675	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
364254002676	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
364254002677	Potassium binding sites [ion binding]; other site
364254002678	Cesium cation binding sites [ion binding]; other site
364254002679	phosphodiesterase; Provisional; Region: PRK12704
364254002680	Similar to transporter, MFS superfamily; nonfunctional due to frameshift; Nonfunctional due to frameshift
364254002681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002682	Uncharacterized conserved protein [Function unknown]; Region: COG0327
364254002683	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
364254002684	peptidase T; Region: peptidase-T; TIGR01882
364254002685	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
364254002686	metal binding site [ion binding]; metal-binding site
364254002687	dimer interface [polypeptide binding]; other site
364254002688	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
364254002689	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
364254002690	active site
364254002691	EamA-like transporter family; Region: EamA; cl01037
364254002692	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
364254002693	EamA-like transporter family; Region: EamA; cl01037
364254002694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
364254002695	binding surface
364254002696	TPR motif; other site
364254002697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
364254002698	binding surface
364254002699	TPR motif; other site
364254002700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
364254002701	TPR motif; other site
364254002702	binding surface
364254002703	Tetratricopeptide repeat; Region: TPR_12; pfam13424
364254002704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
364254002705	binding surface
364254002706	TPR motif; other site
364254002707	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
364254002708	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
364254002709	dimer interface [polypeptide binding]; other site
364254002710	motif 1; other site
364254002711	active site
364254002712	motif 2; other site
364254002713	motif 3; other site
364254002714	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
364254002715	anticodon binding site; other site
364254002716	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
364254002717	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
364254002718	dimer interface [polypeptide binding]; other site
364254002719	anticodon binding site; other site
364254002720	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
364254002721	homodimer interface [polypeptide binding]; other site
364254002722	motif 1; other site
364254002723	active site
364254002724	motif 2; other site
364254002725	GAD domain; Region: GAD; pfam02938
364254002726	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
364254002727	motif 3; other site
364254002728	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
364254002729	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
364254002730	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
364254002731	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
364254002732	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
364254002733	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
364254002734	dimer interface [polypeptide binding]; other site
364254002735	ADP-ribose binding site [chemical binding]; other site
364254002736	active site
364254002737	nudix motif; other site
364254002738	metal binding site [ion binding]; metal-binding site
364254002739	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
364254002740	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164
364254002741	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
364254002742	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
364254002743	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
364254002744	catalytic residue [active]
364254002745	Putative amino acid metabolism; Region: DUF1831; pfam08866
364254002746	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
364254002747	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
364254002748	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
364254002749	Clp amino terminal domain; Region: Clp_N; pfam02861
364254002750	Clp amino terminal domain; Region: Clp_N; pfam02861
364254002751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254002752	Walker A motif; other site
364254002753	ATP binding site [chemical binding]; other site
364254002754	Walker B motif; other site
364254002755	arginine finger; other site
364254002756	Protein of unknown function (DUF2810); Region: DUF2810; cl08159
364254002757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254002758	Walker A motif; other site
364254002759	ATP binding site [chemical binding]; other site
364254002760	Walker B motif; other site
364254002761	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254002762	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
364254002763	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
364254002764	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
364254002765	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
364254002766	generic binding surface I; other site
364254002767	generic binding surface II; other site
364254002768	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
364254002769	active site
364254002770	ADP/pyrophosphate binding site [chemical binding]; other site
364254002771	dimerization interface [polypeptide binding]; other site
364254002772	allosteric effector site; other site
364254002773	fructose-1,6-bisphosphate binding site; other site
364254002774	pyruvate kinase; Provisional; Region: PRK06354
364254002775	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
364254002776	domain interfaces; other site
364254002777	active site
364254002778	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
364254002779	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
364254002780	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
364254002781	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
364254002782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254002783	ATP binding site [chemical binding]; other site
364254002784	Mg2+ binding site [ion binding]; other site
364254002785	G-X-G motif; other site
364254002786	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
364254002787	anchoring element; other site
364254002788	dimer interface [polypeptide binding]; other site
364254002789	ATP binding site [chemical binding]; other site
364254002790	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
364254002791	active site
364254002792	putative metal-binding site [ion binding]; other site
364254002793	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
364254002794	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
364254002795	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
364254002796	CAP-like domain; other site
364254002797	active site
364254002798	primary dimer interface [polypeptide binding]; other site
364254002799	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
364254002800	Domain of unknown function (DUF814); Region: DUF814; pfam05670
364254002801	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
364254002802	Helix-turn-helix domains; Region: HTH; cl00088
364254002803	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
364254002804	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
364254002805	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
364254002806	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
364254002807	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
364254002808	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
364254002809	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
364254002810	dimer interface [polypeptide binding]; other site
364254002811	active site
364254002812	glycine-pyridoxal phosphate binding site [chemical binding]; other site
364254002813	folate binding site [chemical binding]; other site
364254002814	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
364254002815	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
364254002816	active site
364254002817	metal binding site [ion binding]; metal-binding site
364254002818	EamA-like transporter family; Region: EamA; cl01037
364254002819	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
364254002820	EamA-like transporter family; Region: EamA; cl01037
364254002821	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
364254002822	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
364254002823	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002824	Walker A/P-loop; other site
364254002825	ATP binding site [chemical binding]; other site
364254002826	Q-loop/lid; other site
364254002827	ABC transporter signature motif; other site
364254002828	Walker B; other site
364254002829	D-loop; other site
364254002830	H-loop/switch region; other site
364254002831	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
364254002832	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254002833	Coenzyme A binding pocket [chemical binding]; other site
364254002834	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
364254002835	IHF dimer interface [polypeptide binding]; other site
364254002836	IHF - DNA interface [nucleotide binding]; other site
364254002837	GTP-binding protein Der; Reviewed; Region: PRK00093
364254002838	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
364254002839	G1 box; other site
364254002840	GTP/Mg2+ binding site [chemical binding]; other site
364254002841	Switch I region; other site
364254002842	G2 box; other site
364254002843	Switch II region; other site
364254002844	G3 box; other site
364254002845	G4 box; other site
364254002846	G5 box; other site
364254002847	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
364254002848	G1 box; other site
364254002849	GTP/Mg2+ binding site [chemical binding]; other site
364254002850	Switch I region; other site
364254002851	G2 box; other site
364254002852	G3 box; other site
364254002853	Switch II region; other site
364254002854	G4 box; other site
364254002855	G5 box; other site
364254002856	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
364254002857	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
364254002858	RNA binding site [nucleotide binding]; other site
364254002859	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
364254002860	RNA binding site [nucleotide binding]; other site
364254002861	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
364254002862	RNA binding site [nucleotide binding]; other site
364254002863	Low molecular weight phosphatase family; Region: LMWPc; cl00105
364254002864	active site
364254002865	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
364254002866	DltD N-terminal region; Region: DltD_N; pfam04915
364254002867	DltD central region; Region: DltD_M; pfam04918
364254002868	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
364254002869	Phosphopantetheine attachment site; Region: PP-binding; cl09936
364254002870	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
364254002871	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
364254002872	AMP-binding enzyme; Region: AMP-binding; cl15778
364254002873	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
364254002874	Recombination protein O N terminal; Region: RecO_N; cl15812
364254002875	DNA repair protein RecO; Region: reco; TIGR00613
364254002876	Recombination protein O C terminal; Region: RecO_C; pfam02565
364254002877	GTPase Era; Reviewed; Region: era; PRK00089
364254002878	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
364254002879	G1 box; other site
364254002880	GTP/Mg2+ binding site [chemical binding]; other site
364254002881	Switch I region; other site
364254002882	G2 box; other site
364254002883	Switch II region; other site
364254002884	G3 box; other site
364254002885	G4 box; other site
364254002886	G5 box; other site
364254002887	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
364254002888	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
364254002889	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
364254002890	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
364254002891	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254002892	Bacterial SH3 domain; Region: SH3_3; cl02551
364254002893	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
364254002894	active site
364254002895	metal binding site [ion binding]; metal-binding site
364254002896	cytidylate kinase; Provisional; Region: cmk; PRK00023
364254002897	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
364254002898	CMP-binding site; other site
364254002899	The sites determining sugar specificity; other site
364254002900	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
364254002901	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254002902	ATP binding site [chemical binding]; other site
364254002903	putative Mg++ binding site [ion binding]; other site
364254002904	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254002905	nucleotide binding region [chemical binding]; other site
364254002906	ATP-binding site [chemical binding]; other site
364254002907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
364254002908	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
364254002909	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
364254002910	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
364254002911	Similar to glycosyltransferase; nonfunctional due to frameshift
364254002912	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
364254002913	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
364254002914	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
364254002915	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
364254002916	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
364254002917	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
364254002918	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
364254002919	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
364254002920	DNA binding residues [nucleotide binding]
364254002921	DNA primase; Validated; Region: dnaG; PRK05667
364254002922	CHC2 zinc finger; Region: zf-CHC2; cl15369
364254002923	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
364254002924	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
364254002925	active site
364254002926	metal binding site [ion binding]; metal-binding site
364254002927	interdomain interaction site; other site
364254002928	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
364254002929	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
364254002930	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
364254002931	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
364254002932	dimer interface [polypeptide binding]; other site
364254002933	motif 1; other site
364254002934	active site
364254002935	motif 2; other site
364254002936	motif 3; other site
364254002937	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
364254002938	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254002939	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
364254002940	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002941	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002942	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
364254002943	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002944	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002945	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254002946	Int/Topo IB signature motif; other site
364254002947	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002948	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
364254002949	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
364254002950	HsdM N-terminal domain; Region: HsdM_N; pfam12161
364254002951	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
364254002952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254002953	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
364254002954	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
364254002955	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
364254002956	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254002957	ATP binding site [chemical binding]; other site
364254002958	putative Mg++ binding site [ion binding]; other site
364254002959	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
364254002960	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
364254002961	nudix motif; other site
364254002962	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
364254002963	active site
364254002964	maltose O-acetyltransferase; Provisional; Region: PRK10092
364254002965	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
364254002966	active site
364254002967	substrate binding site [chemical binding]; other site
364254002968	trimer interface [polypeptide binding]; other site
364254002969	CoA binding site [chemical binding]; other site
364254002970	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254002971	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
364254002972	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254002973	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
364254002974	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
364254002975	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
364254002976	active site
364254002977	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
364254002978	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
364254002979	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
364254002980	Recombination protein U; Region: RecU; cl01314
364254002981	Transglycosylase; Region: Transgly; cl07896
364254002982	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
364254002983	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254002984	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
364254002985	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
364254002986	active site
364254002987	Int/Topo IB signature motif; other site
364254002988	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
364254002989	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
364254002990	RNA binding site [nucleotide binding]; other site
364254002991	Protein of unknown function (DUF441); Region: DUF441; cl01041
364254002992	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
364254002993	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
364254002994	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
364254002995	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254002996	RNA binding surface [nucleotide binding]; other site
364254002997	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
364254002998	active site
364254002999	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
364254003000	ScpA/B protein; Region: ScpA_ScpB; cl00598
364254003001	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254003002	Protein of unknown function (DUF805); Region: DUF805; cl01224
364254003003	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
364254003004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254003005	Walker A motif; other site
364254003006	ATP binding site [chemical binding]; other site
364254003007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003008	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
364254003009	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
364254003010	active site
364254003011	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
364254003012	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
364254003013	active site
364254003014	Int/Topo IB signature motif; other site
364254003015	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
364254003016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254003017	S-adenosylmethionine binding site [chemical binding]; other site
364254003018	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
364254003019	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
364254003020	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
364254003021	Protein of unknown function (DUF464); Region: DUF464; cl01080
364254003022	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
364254003023	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
364254003024	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
364254003025	nudix motif; other site
364254003026	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
364254003027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003028	NAD(P) binding site [chemical binding]; other site
364254003029	active site
364254003030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254003031	Coenzyme A binding pocket [chemical binding]; other site
364254003032	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
364254003033	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
364254003034	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
364254003035	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
364254003036	putative NAD(P) binding site [chemical binding]; other site
364254003037	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
364254003038	CHY zinc finger; Region: zf-CHY; pfam05495
364254003039	Predicted transcriptional regulator [Transcription]; Region: COG1959
364254003040	Helix-turn-helix domains; Region: HTH; cl00088
364254003041	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
364254003042	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
364254003043	NADP binding site [chemical binding]; other site
364254003044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003045	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
364254003046	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
364254003047	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
364254003048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003049	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
364254003050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003051	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
364254003052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003053	NAD(P) binding site [chemical binding]; other site
364254003054	active site
364254003055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003056	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
364254003057	Rhamnan synthesis protein F; Region: RgpF; cl01529
364254003058	Rhamnan synthesis protein F; Region: RgpF; cl01529
364254003059	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
364254003060	active site
364254003061	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
364254003062	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
364254003063	Ligand binding site; other site
364254003064	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003065	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
364254003066	putative ADP-binding pocket [chemical binding]; other site
364254003067	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003068	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
364254003069	putative ADP-binding pocket [chemical binding]; other site
364254003070	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003071	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
364254003072	putative ADP-binding pocket [chemical binding]; other site
364254003073	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
364254003074	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254003075	putative ADP-binding pocket [chemical binding]; other site
364254003076	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
364254003077	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
364254003078	putative trimer interface [polypeptide binding]; other site
364254003079	putative CoA binding site [chemical binding]; other site
364254003080	Bacterial sugar transferase; Region: Bac_transf; cl00939
364254003081	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
364254003082	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
364254003083	inhibitor-cofactor binding pocket; inhibition site
364254003084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254003085	catalytic residue [active]
364254003086	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
364254003087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003089	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
364254003090	NAD(P) binding site [chemical binding]; other site
364254003091	homodimer interface [polypeptide binding]; other site
364254003092	substrate binding site [chemical binding]; other site
364254003093	active site
364254003094	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
364254003095	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003096	Chain length determinant protein; Region: Wzz; cl15801
364254003097	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
364254003098	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
364254003099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254003100	Coenzyme A binding pocket [chemical binding]; other site
364254003101	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
364254003102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254003103	S-adenosylmethionine binding site [chemical binding]; other site
364254003104	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
364254003105	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
364254003106	esterase; Provisional; Region: PRK10566
364254003107	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254003108	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
364254003109	active site
364254003110	motif I; other site
364254003111	motif II; other site
364254003112	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
364254003113	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254003114	diaminopimelate decarboxylase; Region: lysA; TIGR01048
364254003115	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
364254003116	active site
364254003117	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
364254003118	substrate binding site [chemical binding]; other site
364254003119	catalytic residues [active]
364254003120	dimer interface [polypeptide binding]; other site
364254003121	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
364254003122	active site 1 [active]
364254003123	dimer interface [polypeptide binding]; other site
364254003124	hexamer interface [polypeptide binding]; other site
364254003125	active site 2 [active]
364254003126	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
364254003127	Peptidase family C69; Region: Peptidase_C69; pfam03577
364254003128	Cupin domain; Region: Cupin_2; cl09118
364254003129	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
364254003130	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
364254003131	Predicted membrane protein [Function unknown]; Region: COG2364
364254003132	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
364254003133	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
364254003134	catalytic site [active]
364254003135	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
364254003136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254003137	Coenzyme A binding pocket [chemical binding]; other site
364254003138	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
364254003139	PLD-like domain; Region: PLDc_2; pfam13091
364254003140	putative homodimer interface [polypeptide binding]; other site
364254003141	putative active site [active]
364254003142	catalytic site [active]
364254003143	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
364254003144	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254003145	ATP binding site [chemical binding]; other site
364254003146	putative Mg++ binding site [ion binding]; other site
364254003147	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254003148	nucleotide binding region [chemical binding]; other site
364254003149	ATP-binding site [chemical binding]; other site
364254003150	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
364254003151	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
364254003152	active site
364254003153	8-oxo-dGMP binding site [chemical binding]; other site
364254003154	nudix motif; other site
364254003155	metal binding site [ion binding]; metal-binding site
364254003156	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254003157	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254003158	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
364254003159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
364254003160	metal binding site [ion binding]; metal-binding site
364254003161	active site
364254003162	I-site; other site
364254003163	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
364254003164	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
364254003165	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
364254003166	DXD motif; other site
364254003167	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
364254003168	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
364254003169	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
364254003170	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
364254003171	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
364254003172	metal binding site [ion binding]; metal-binding site
364254003173	active site
364254003174	I-site; other site
364254003175	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
364254003176	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
364254003177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254003179	UbiA prenyltransferase family; Region: UbiA; cl00337
364254003180	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
364254003181	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
364254003182	substrate binding pocket [chemical binding]; other site
364254003183	chain length determination region; other site
364254003184	substrate-Mg2+ binding site; other site
364254003185	catalytic residues [active]
364254003186	aspartate-rich region 1; other site
364254003187	active site lid residues [active]
364254003188	aspartate-rich region 2; other site
364254003189	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
364254003190	The CYD subfamily implicated in cytochrome bd biogenesis.  The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247
364254003191	Walker A/P-loop; other site
364254003192	ATP binding site [chemical binding]; other site
364254003193	Q-loop/lid; other site
364254003194	ABC transporter signature motif; other site
364254003195	Walker B; other site
364254003196	D-loop; other site
364254003197	H-loop/switch region; other site
364254003198	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
364254003199	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
364254003200	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003201	Walker A/P-loop; other site
364254003202	ATP binding site [chemical binding]; other site
364254003203	Q-loop/lid; other site
364254003204	ABC transporter signature motif; other site
364254003205	Walker B; other site
364254003206	D-loop; other site
364254003207	H-loop/switch region; other site
364254003208	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
364254003209	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
364254003210	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
364254003211	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
364254003212	asparagine synthetase A; Reviewed; Region: PRK06462
364254003213	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
364254003214	dimer interface [polypeptide binding]; other site
364254003215	active site
364254003216	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254003217	putative peptidoglycan binding site; other site
364254003218	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
364254003219	active site residue [active]
364254003220	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254003221	putative peptidoglycan binding site; other site
364254003222	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
364254003223	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
364254003224	active site
364254003225	metal binding site [ion binding]; metal-binding site
364254003226	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
364254003227	nucleotide binding site/active site [active]
364254003228	HIT family signature motif; other site
364254003229	catalytic residue [active]
364254003230	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
364254003231	Uncharacterized conserved protein [Function unknown]; Region: COG1284
364254003232	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254003233	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
364254003234	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
364254003235	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
364254003236	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
364254003237	active site
364254003238	HIGH motif; other site
364254003239	nucleotide binding site [chemical binding]; other site
364254003240	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
364254003241	active site
364254003242	KMSKS motif; other site
364254003243	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
364254003244	tRNA binding surface [nucleotide binding]; other site
364254003245	anticodon binding site; other site
364254003246	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
364254003247	DivIVA protein; Region: DivIVA; pfam05103
364254003248	DivIVA domain; Region: DivI1A_domain; TIGR03544
364254003249	Plant ATP synthase F0; Region: YMF19; cl07975
364254003250	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
364254003251	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
364254003252	YGGT family; Region: YGGT; cl00508
364254003253	Protein of unknown function (DUF552); Region: DUF552; cl00775
364254003254	cell division protein FtsZ; Validated; Region: PRK09330
364254003255	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
364254003256	nucleotide binding site [chemical binding]; other site
364254003257	SulA interaction site; other site
364254003258	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
364254003259	Cell division protein FtsA; Region: FtsA; cl11496
364254003260	Cell division protein FtsA; Region: FtsA; cl11496
364254003261	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
364254003262	Cell division protein FtsQ; Region: FtsQ; pfam03799
364254003263	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
364254003264	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
364254003265	active site
364254003266	homodimer interface [polypeptide binding]; other site
364254003267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003268	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
364254003269	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254003270	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
364254003271	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
364254003272	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
364254003273	Mg++ binding site [ion binding]; other site
364254003274	putative catalytic motif [active]
364254003275	putative substrate binding site [chemical binding]; other site
364254003276	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
364254003277	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
364254003278	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254003279	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
364254003280	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
364254003281	Septum formation initiator; Region: DivIC; cl11433
364254003282	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
364254003283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
364254003285	MraZ protein; Region: MraZ; pfam02381
364254003286	MraZ protein; Region: MraZ; pfam02381
364254003287	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
364254003288	aspartate kinase I; Reviewed; Region: PRK08210
364254003289	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
364254003290	nucleotide binding site [chemical binding]; other site
364254003291	substrate binding site [chemical binding]; other site
364254003292	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
364254003293	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
364254003294	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
364254003295	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
364254003296	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
364254003297	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254003298	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254003299	substrate binding pocket [chemical binding]; other site
364254003300	membrane-bound complex binding site; other site
364254003301	hinge residues; other site
364254003302	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
364254003303	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003304	Walker A/P-loop; other site
364254003305	ATP binding site [chemical binding]; other site
364254003306	Q-loop/lid; other site
364254003307	ABC transporter signature motif; other site
364254003308	Walker B; other site
364254003309	D-loop; other site
364254003310	H-loop/switch region; other site
364254003311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254003312	dimer interface [polypeptide binding]; other site
364254003313	conserved gate region; other site
364254003314	putative PBP binding loops; other site
364254003315	ABC-ATPase subunit interface; other site
364254003316	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
364254003317	Switch I; other site
364254003318	Switch II; other site
364254003319	septum formation inhibitor; Reviewed; Region: minC; PRK00513
364254003320	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
364254003321	rod shape-determining protein MreD; Region: MreD; cl01087
364254003322	rod shape-determining protein MreC; Region: MreC; pfam04085
364254003323	rod shape-determining protein MreB; Provisional; Region: PRK13927
364254003324	Cell division protein FtsA; Region: FtsA; cl11496
364254003325	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
364254003326	DNA-binding site [nucleotide binding]; DNA binding site
364254003327	RNA-binding motif; other site
364254003328	hypothetical protein; Reviewed; Region: PRK00024
364254003329	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
364254003330	MPN+ (JAMM) motif; other site
364254003331	Zinc-binding site [ion binding]; other site
364254003332	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
364254003333	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
364254003334	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
364254003335	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
364254003336	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
364254003337	active site
364254003338	HIGH motif; other site
364254003339	nucleotide binding site [chemical binding]; other site
364254003340	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
364254003341	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
364254003342	active site
364254003343	KMSKS motif; other site
364254003344	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
364254003345	tRNA binding surface [nucleotide binding]; other site
364254003346	anticodon binding site; other site
364254003347	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
364254003348	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
364254003349	THUMP domain; Region: THUMP; cl12076
364254003350	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
364254003351	Ligand Binding Site [chemical binding]; other site
364254003352	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
364254003353	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
364254003354	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
364254003355	catalytic residue [active]
364254003356	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
364254003357	GAF domain; Region: GAF; cl15785
364254003358	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
364254003359	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
364254003360	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254003361	RNA binding surface [nucleotide binding]; other site
364254003362	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
364254003363	recombination factor protein RarA; Reviewed; Region: PRK13342
364254003364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254003365	Walker A motif; other site
364254003366	ATP binding site [chemical binding]; other site
364254003367	Walker B motif; other site
364254003368	arginine finger; other site
364254003369	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
364254003370	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
364254003371	Ligand Binding Site [chemical binding]; other site
364254003372	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
364254003373	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
364254003374	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
364254003375	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254003376	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
364254003377	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
364254003378	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
364254003379	active site
364254003380	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
364254003381	possible sortase recognition-binding site
364254003382	Protein of unknown function (DUF421); Region: DUF421; cl00990
364254003383	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
364254003384	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
364254003385	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254003386	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
364254003387	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
364254003388	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254003389	active site
364254003390	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
364254003391	DHH family; Region: DHH; pfam01368
364254003392	DHHA1 domain; Region: DHHA1; pfam02272
364254003393	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
364254003394	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
364254003395	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003396	NAD(P) binding site [chemical binding]; other site
364254003397	active site
364254003398	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
364254003399	OpgC protein; Region: OpgC_C; cl00792
364254003400	Acyltransferase family; Region: Acyl_transf_3; pfam01757
364254003401	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
364254003402	catalytic triad [active]
364254003403	catalytic triad [active]
364254003404	oxyanion hole [active]
364254003405	GTPase CgtA; Reviewed; Region: obgE; PRK12297
364254003406	GTP1/OBG; Region: GTP1_OBG; pfam01018
364254003407	Obg GTPase; Region: Obg; cd01898
364254003408	G1 box; other site
364254003409	GTP/Mg2+ binding site [chemical binding]; other site
364254003410	Switch I region; other site
364254003411	G2 box; other site
364254003412	G3 box; other site
364254003413	Switch II region; other site
364254003414	G4 box; other site
364254003415	G5 box; other site
364254003416	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
364254003417	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
364254003418	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
364254003419	GIY-YIG motif/motif A; other site
364254003420	active site
364254003421	catalytic site [active]
364254003422	putative DNA binding site [nucleotide binding]; other site
364254003423	metal binding site [ion binding]; metal-binding site
364254003424	UvrB/uvrC motif; Region: UVR; pfam02151
364254003425	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
364254003426	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
364254003427	DNA binding site [nucleotide binding]
364254003428	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
364254003429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003430	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
364254003431	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
364254003432	active site
364254003433	metal binding site [ion binding]; metal-binding site
364254003434	homotetramer interface [polypeptide binding]; other site
364254003435	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
364254003436	active site
364254003437	dimerization interface [polypeptide binding]; other site
364254003438	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
364254003439	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
364254003440	catalytic residues [active]
364254003441	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
364254003442	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003443	Walker A/P-loop; other site
364254003444	ATP binding site [chemical binding]; other site
364254003445	Q-loop/lid; other site
364254003446	ABC transporter signature motif; other site
364254003447	Walker B; other site
364254003448	D-loop; other site
364254003449	H-loop/switch region; other site
364254003450	Smr domain; Region: Smr; cl02619
364254003451	Colicin V production protein; Region: Colicin_V; cl00567
364254003452	Cell division protein ZapA; Region: ZapA; cl01146
364254003453	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
364254003454	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
364254003455	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
364254003456	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
364254003457	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
364254003458	motif 1; other site
364254003459	active site
364254003460	motif 2; other site
364254003461	motif 3; other site
364254003462	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
364254003463	DHHA1 domain; Region: DHHA1; pfam02272
364254003464	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
364254003465	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
364254003466	ATP binding site [chemical binding]; other site
364254003467	Mg++ binding site [ion binding]; other site
364254003468	motif III; other site
364254003469	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254003470	nucleotide binding region [chemical binding]; other site
364254003471	ATP-binding site [chemical binding]; other site
364254003472	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
364254003473	DHH family; Region: DHH; pfam01368
364254003474	DHHA1 domain; Region: DHHA1; pfam02272
364254003475	Acetokinase family; Region: Acetate_kinase; cl01029
364254003476	propionate/acetate kinase; Provisional; Region: PRK12379
364254003477	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
364254003478	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
364254003479	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
364254003480	4Fe-4S binding domain; Region: Fer4; cl02805
364254003481	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
364254003482	Cysteine-rich domain; Region: CCG; pfam02754
364254003483	Cysteine-rich domain; Region: CCG; pfam02754
364254003484	amino acid transporter; Region: 2A0306; TIGR00909
364254003485	Spore germination protein; Region: Spore_permease; cl15802
364254003486	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
364254003487	Ligand Binding Site [chemical binding]; other site
364254003488	Preprotein translocase subunit; Region: YajC; cl00806
364254003489	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
364254003490	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
364254003491	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
364254003492	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
364254003493	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
364254003494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254003495	Walker A motif; other site
364254003496	ATP binding site [chemical binding]; other site
364254003497	Walker B motif; other site
364254003498	arginine finger; other site
364254003499	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
364254003500	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
364254003501	RuvA N terminal domain; Region: RuvA_N; pfam01330
364254003502	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
364254003503	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
364254003504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254003505	ATP binding site [chemical binding]; other site
364254003506	Mg2+ binding site [ion binding]; other site
364254003507	G-X-G motif; other site
364254003508	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
364254003509	ATP binding site [chemical binding]; other site
364254003510	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
364254003511	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
364254003512	MutS domain I; Region: MutS_I; pfam01624
364254003513	MutS domain II; Region: MutS_II; pfam05188
364254003514	MutS family domain IV; Region: MutS_IV; pfam05190
364254003515	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
364254003516	Walker A/P-loop; other site
364254003517	ATP binding site [chemical binding]; other site
364254003518	Q-loop/lid; other site
364254003519	ABC transporter signature motif; other site
364254003520	Walker B; other site
364254003521	D-loop; other site
364254003522	H-loop/switch region; other site
364254003523	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
364254003524	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
364254003525	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254003526	recombinase A; Provisional; Region: recA; PRK09354
364254003527	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
364254003528	hexamer interface [polypeptide binding]; other site
364254003529	Walker A motif; other site
364254003530	ATP binding site [chemical binding]; other site
364254003531	Walker B motif; other site
364254003532	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
364254003533	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254003534	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
364254003535	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
364254003536	classical (c) SDRs; Region: SDR_c; cd05233
364254003537	NAD(P) binding site [chemical binding]; other site
364254003538	active site
364254003539	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
364254003540	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
364254003541	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
364254003542	Similar to conserved hypothetical protein; nonfunctional due to interrupting stop codon
364254003543	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
364254003544	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003545	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
364254003546	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
364254003547	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
364254003548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254003549	S-adenosylmethionine binding site [chemical binding]; other site
364254003550	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
364254003551	putative deacylase active site [active]
364254003552	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
364254003553	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
364254003554	active site
364254003555	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
364254003556	CutC family; Region: CutC; cl01218
364254003557	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
364254003558	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
364254003559	structural tetrad; other site
364254003560	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
364254003561	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
364254003562	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
364254003563	active site
364254003564	substrate binding site [chemical binding]; other site
364254003565	metal binding site [ion binding]; metal-binding site
364254003566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
364254003567	YbbR-like protein; Region: YbbR; pfam07949
364254003568	YbbR-like protein; Region: YbbR; pfam07949
364254003569	Uncharacterized conserved protein [Function unknown]; Region: COG1624
364254003570	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
364254003571	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
364254003572	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
364254003573	FAD binding domain; Region: FAD_binding_4; pfam01565
364254003574	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
364254003575	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
364254003576	active site
364254003577	catalytic site [active]
364254003578	substrate binding site [chemical binding]; other site
364254003579	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
364254003580	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
364254003581	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
364254003582	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
364254003583	ligand binding site [chemical binding]; other site
364254003584	active site
364254003585	UGI interface [polypeptide binding]; other site
364254003586	catalytic site [active]
364254003587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254003588	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
364254003589	active site
364254003590	motif I; other site
364254003591	motif II; other site
364254003592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254003593	motif II; other site
364254003594	Scramblase; Region: Scramblase; cl02043
364254003595	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
364254003596	SmpB-tmRNA interface; other site
364254003597	ribonuclease R; Region: RNase_R; TIGR02063
364254003598	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
364254003599	RNB domain; Region: RNB; pfam00773
364254003600	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
364254003601	RNA binding site [nucleotide binding]; other site
364254003602	Preprotein translocase SecG subunit; Region: SecG; cl09123
364254003603	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
364254003604	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
364254003605	Cl- selectivity filter; other site
364254003606	Cl- binding residues [ion binding]; other site
364254003607	pore gating glutamate residue; other site
364254003608	dimer interface [polypeptide binding]; other site
364254003609	H+/Cl- coupling transport residue; other site
364254003610	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
364254003611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254003612	Major Facilitator Superfamily; Region: MFS_1; pfam07690
364254003613	putative substrate translocation pore; other site
364254003614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
364254003615	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
364254003616	dimerization interface [polypeptide binding]; other site
364254003617	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
364254003618	dimer interface [polypeptide binding]; other site
364254003619	phosphorylation site [posttranslational modification]
364254003620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254003621	ATP binding site [chemical binding]; other site
364254003622	Mg2+ binding site [ion binding]; other site
364254003623	G-X-G motif; other site
364254003624	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
364254003625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254003626	active site
364254003627	phosphorylation site [posttranslational modification]
364254003628	intermolecular recognition site; other site
364254003629	dimerization interface [polypeptide binding]; other site
364254003630	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
364254003631	DNA binding site [nucleotide binding]
364254003632	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
364254003633	active site
364254003634	DNA polymerase IV; Validated; Region: PRK02406
364254003635	DNA binding site [nucleotide binding]
364254003636	enolase; Provisional; Region: eno; PRK00077
364254003637	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
364254003638	dimer interface [polypeptide binding]; other site
364254003639	metal binding site [ion binding]; metal-binding site
364254003640	substrate binding pocket [chemical binding]; other site
364254003641	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
364254003642	substrate binding site [chemical binding]; other site
364254003643	dimer interface [polypeptide binding]; other site
364254003644	catalytic triad [active]
364254003645	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
364254003646	Phosphoglycerate kinase; Region: PGK; pfam00162
364254003647	substrate binding site [chemical binding]; other site
364254003648	hinge regions; other site
364254003649	ADP binding site [chemical binding]; other site
364254003650	catalytic site [active]
364254003651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003652	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
364254003653	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
364254003654	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
364254003655	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
364254003656	Clp protease; Region: CLP_protease; pfam00574
364254003657	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
364254003658	oligomer interface [polypeptide binding]; other site
364254003659	active site residues [active]
364254003660	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
364254003661	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
364254003662	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
364254003663	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
364254003664	phosphate binding site [ion binding]; other site
364254003665	putative substrate binding pocket [chemical binding]; other site
364254003666	dimer interface [polypeptide binding]; other site
364254003667	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
364254003668	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
364254003669	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
364254003670	NADH(P)-binding; Region: NAD_binding_10; pfam13460
364254003671	NAD(P) binding site [chemical binding]; other site
364254003672	putative active site [active]
364254003673	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
364254003674	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
364254003675	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
364254003676	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
364254003677	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
364254003678	excinuclease ABC subunit B; Provisional; Region: PRK05298
364254003679	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254003680	ATP binding site [chemical binding]; other site
364254003681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254003682	nucleotide binding region [chemical binding]; other site
364254003683	ATP-binding site [chemical binding]; other site
364254003684	Ultra-violet resistance protein B; Region: UvrB; pfam12344
364254003685	UvrB/uvrC motif; Region: UVR; pfam02151
364254003686	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
364254003687	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
364254003688	active site
364254003689	substrate binding site [chemical binding]; other site
364254003690	metal binding site [ion binding]; metal-binding site
364254003691	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
364254003692	HPr kinase/phosphorylase; Provisional; Region: PRK05428
364254003693	DRTGG domain; Region: DRTGG; cl12147
364254003694	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
364254003695	Hpr binding site; other site
364254003696	active site
364254003697	homohexamer subunit interaction site [polypeptide binding]; other site
364254003698	Membrane protein of unknown function; Region: DUF360; cl00850
364254003699	PspC domain; Region: PspC; cl00864
364254003700	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
364254003701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
364254003702	dimer interface [polypeptide binding]; other site
364254003703	phosphorylation site [posttranslational modification]
364254003704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
364254003705	ATP binding site [chemical binding]; other site
364254003706	Mg2+ binding site [ion binding]; other site
364254003707	G-X-G motif; other site
364254003708	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
364254003709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
364254003710	active site
364254003711	phosphorylation site [posttranslational modification]
364254003712	intermolecular recognition site; other site
364254003713	dimerization interface [polypeptide binding]; other site
364254003714	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
364254003715	DNA binding site [nucleotide binding]
364254003716	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
364254003717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254003718	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254003719	peptide chain release factor 2; Validated; Region: prfB; PRK00578
364254003720	RF-1 domain; Region: RF-1; cl02875
364254003721	RF-1 domain; Region: RF-1; cl02875
364254003722	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
364254003723	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003724	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
364254003725	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254003726	nucleotide binding region [chemical binding]; other site
364254003727	ATP-binding site [chemical binding]; other site
364254003728	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
364254003729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254003730	putative substrate translocation pore; other site
364254003731	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
364254003732	30S subunit binding site; other site
364254003733	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254003734	Int/Topo IB signature motif; other site
364254003735	Domain of unknown function (DUF955); Region: DUF955; cl01076
364254003736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254003737	non-specific DNA binding site [nucleotide binding]; other site
364254003738	salt bridge; other site
364254003739	sequence-specific DNA binding site [nucleotide binding]; other site
364254003740	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254003741	non-specific DNA binding site [nucleotide binding]; other site
364254003742	salt bridge; other site
364254003743	sequence-specific DNA binding site [nucleotide binding]; other site
364254003744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254003745	non-specific DNA binding site [nucleotide binding]; other site
364254003746	salt bridge; other site
364254003747	sequence-specific DNA binding site [nucleotide binding]; other site
364254003748	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
364254003749	polymerase nucleotide-binding site; other site
364254003750	DNA-binding residues [nucleotide binding]; DNA binding site
364254003751	nucleotide binding site [chemical binding]; other site
364254003752	primase nucleotide-binding site [nucleotide binding]; other site
364254003753	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
364254003754	D5 N terminal like; Region: D5_N; cl07360
364254003755	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
364254003756	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
364254003757	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
364254003758	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254003759	active site
364254003760	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
364254003761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254003762	ATP binding site [chemical binding]; other site
364254003763	putative Mg++ binding site [ion binding]; other site
364254003764	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254003765	nucleotide binding region [chemical binding]; other site
364254003766	ATP-binding site [chemical binding]; other site
364254003767	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
364254003768	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
364254003769	Mg++ binding site [ion binding]; other site
364254003770	putative catalytic motif [active]
364254003771	substrate binding site [chemical binding]; other site
364254003772	Amino acid permease; Region: AA_permease_2; pfam13520
364254003773	K+ potassium transporter; Region: K_trans; cl15781
364254003774	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
364254003775	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
364254003776	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254003777	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
364254003778	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
364254003779	ring oligomerisation interface [polypeptide binding]; other site
364254003780	ATP/Mg binding site [chemical binding]; other site
364254003781	stacking interactions; other site
364254003782	hinge regions; other site
364254003783	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
364254003784	oligomerisation interface [polypeptide binding]; other site
364254003785	mobile loop; other site
364254003786	roof hairpin; other site
364254003787	CAAX protease self-immunity; Region: Abi; cl00558
364254003788	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
364254003789	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
364254003790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003791	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
364254003792	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254003793	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254003794	ABC transporter; Region: ABC_tran_2; pfam12848
364254003795	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
364254003796	UGMP family protein; Validated; Region: PRK09604
364254003797	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
364254003798	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
364254003799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254003800	Coenzyme A binding pocket [chemical binding]; other site
364254003801	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
364254003802	Glycoprotease family; Region: Peptidase_M22; pfam00814
364254003803	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
364254003804	active site
364254003805	homotetramer interface [polypeptide binding]; other site
364254003806	homodimer interface [polypeptide binding]; other site
364254003807	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
364254003808	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
364254003809	active site
364254003810	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
364254003811	active site
364254003812	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
364254003813	Predicted methyltransferases [General function prediction only]; Region: COG0313
364254003814	Protein of unknown function (DUF972); Region: DUF972; pfam06156
364254003815	DNA polymerase III subunit delta'; Validated; Region: PRK08058
364254003816	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254003817	thymidylate kinase; Validated; Region: tmk; PRK00698
364254003818	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
364254003819	TMP-binding site; other site
364254003820	ATP-binding site [chemical binding]; other site
364254003821	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
364254003822	recombination protein RecR; Reviewed; Region: recR; PRK00076
364254003823	RecR protein; Region: RecR; pfam02132
364254003824	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
364254003825	putative active site [active]
364254003826	putative metal-binding site [ion binding]; other site
364254003827	tetramer interface [polypeptide binding]; other site
364254003828	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
364254003829	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
364254003830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254003831	Walker A motif; other site
364254003832	ATP binding site [chemical binding]; other site
364254003833	Walker B motif; other site
364254003834	arginine finger; other site
364254003835	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
364254003836	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
364254003837	nucleoside/Zn binding site; other site
364254003838	dimer interface [polypeptide binding]; other site
364254003839	catalytic motif [active]
364254003840	Similar to conserved hypothetical protein; nonfunctional due to interrupting stop codon
364254003841	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
364254003842	catalytic residues [active]
364254003843	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254003844	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
364254003845	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
364254003846	Class I ribonucleotide reductase; Region: RNR_I; cd01679
364254003847	active site
364254003848	dimer interface [polypeptide binding]; other site
364254003849	catalytic residues [active]
364254003850	effector binding site; other site
364254003851	R2 peptide binding site; other site
364254003852	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
364254003853	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
364254003854	dimer interface [polypeptide binding]; other site
364254003855	putative radical transfer pathway; other site
364254003856	diiron center [ion binding]; other site
364254003857	tyrosyl radical; other site
364254003858	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
364254003859	Uncharacterized conserved protein [Function unknown]; Region: COG2898
364254003860	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
364254003861	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
364254003862	core dimer interface [polypeptide binding]; other site
364254003863	peripheral dimer interface [polypeptide binding]; other site
364254003864	L10 interface [polypeptide binding]; other site
364254003865	L11 interface [polypeptide binding]; other site
364254003866	putative EF-Tu interaction site [polypeptide binding]; other site
364254003867	putative EF-G interaction site [polypeptide binding]; other site
364254003868	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
364254003869	23S rRNA interface [nucleotide binding]; other site
364254003870	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
364254003871	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
364254003872	mRNA/rRNA interface [nucleotide binding]; other site
364254003873	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
364254003874	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
364254003875	23S rRNA interface [nucleotide binding]; other site
364254003876	L7/L12 interface [polypeptide binding]; other site
364254003877	putative thiostrepton binding site; other site
364254003878	L25 interface [polypeptide binding]; other site
364254003879	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
364254003880	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
364254003881	putative homodimer interface [polypeptide binding]; other site
364254003882	KOW motif; Region: KOW; cl00354
364254003883	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
364254003884	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
364254003885	YacP-like NYN domain; Region: NYN_YacP; cl01491
364254003886	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
364254003887	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
364254003888	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
364254003889	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
364254003890	active site
364254003891	metal binding site [ion binding]; metal-binding site
364254003892	dimerization interface [polypeptide binding]; other site
364254003893	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
364254003894	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
364254003895	active site
364254003896	HIGH motif; other site
364254003897	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
364254003898	KMSKS motif; other site
364254003899	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
364254003900	tRNA binding surface [nucleotide binding]; other site
364254003901	anticodon binding site; other site
364254003902	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
364254003903	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
364254003904	HIGH motif; other site
364254003905	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
364254003906	active site
364254003907	KMSKS motif; other site
364254003908	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
364254003909	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
364254003910	putative active site [active]
364254003911	DNA repair protein RadA; Provisional; Region: PRK11823
364254003912	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
364254003913	Walker A motif/ATP binding site; other site
364254003914	ATP binding site [chemical binding]; other site
364254003915	Walker B motif; other site
364254003916	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
364254003917	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
364254003918	trimer interface [polypeptide binding]; other site
364254003919	active site
364254003920	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254003921	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
364254003922	trimer interface [polypeptide binding]; other site
364254003923	active site
364254003924	G bulge; other site
364254003925	Enterocin A Immunity; Region: EntA_Immun; pfam08951
364254003926	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254003927	catalytic core [active]
364254003928	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254003929	Membrane transport protein; Region: Mem_trans; cl09117
364254003930	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
364254003931	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
364254003932	dimer interface [polypeptide binding]; other site
364254003933	active site
364254003934	CoA binding pocket [chemical binding]; other site
364254003935	hypothetical protein; Provisional; Region: PRK04351
364254003936	SprT homologues; Region: SprT; cl01182
364254003937	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
364254003938	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
364254003939	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
364254003940	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
364254003941	RNA binding site [nucleotide binding]; other site
364254003942	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
364254003943	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
364254003944	homodimer interface [polypeptide binding]; other site
364254003945	NAD binding pocket [chemical binding]; other site
364254003946	ATP binding pocket [chemical binding]; other site
364254003947	Mg binding site [ion binding]; other site
364254003948	active-site loop [active]
364254003949	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
364254003950	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
364254003951	active site
364254003952	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
364254003953	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
364254003954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
364254003955	DNA-binding site [nucleotide binding]; DNA binding site
364254003956	UTRA domain; Region: UTRA; cl01230
364254003957	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
364254003958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003959	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
364254003960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254003961	putative substrate translocation pore; other site
364254003962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
364254003963	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
364254003964	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254003965	putative peptidoglycan binding site; other site
364254003966	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
364254003967	active site
364254003968	tetramer interface; other site
364254003969	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
364254003970	active site
364254003971	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254003972	GtrA-like protein; Region: GtrA; cl00971
364254003973	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
364254003974	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
364254003975	ornithine cyclodeaminase; Validated; Region: PRK08618
364254003976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254003977	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
364254003978	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
364254003979	Helix-turn-helix domains; Region: HTH; cl00088
364254003980	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
364254003981	C-terminal domain interface [polypeptide binding]; other site
364254003982	sugar binding site [chemical binding]; other site
364254003983	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
364254003984	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
364254003985	active site
364254003986	homodimer interface [polypeptide binding]; other site
364254003987	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
364254003988	Amino acid permease; Region: AA_permease_2; pfam13520
364254003989	Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776
364254003990	beta-phosphoglucomutase; Region: bPGM; TIGR01990
364254003991	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254003992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254003993	motif II; other site
364254003994	maltose phosphorylase; Provisional; Region: PRK13807
364254003995	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
364254003996	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
364254003997	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
364254003998	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
364254003999	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
364254004000	active site
364254004001	catalytic residues [active]
364254004002	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
364254004003	Major Facilitator Superfamily; Region: MFS_1; pfam07690
364254004004	Transcriptional regulators [Transcription]; Region: PurR; COG1609
364254004005	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
364254004006	DNA binding site [nucleotide binding]
364254004007	domain linker motif; other site
364254004008	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
364254004009	putative dimerization interface [polypeptide binding]; other site
364254004010	putative ligand binding site [chemical binding]; other site
364254004011	K+ potassium transporter; Region: K_trans; cl15781
364254004012	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
364254004013	DEAD-like helicases superfamily; Region: DEXDc; smart00487
364254004014	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004015	ATP binding site [chemical binding]; other site
364254004016	putative Mg++ binding site [ion binding]; other site
364254004017	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254004018	nucleotide binding region [chemical binding]; other site
364254004019	ATP-binding site [chemical binding]; other site
364254004020	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
364254004021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004022	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
364254004023	active site
364254004024	homodimer interface [polypeptide binding]; other site
364254004025	catalytic site [active]
364254004026	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
364254004027	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
364254004028	homodimer interface [polypeptide binding]; other site
364254004029	active site pocket [active]
364254004030	glycogen synthase; Provisional; Region: glgA; PRK00654
364254004031	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
364254004032	ADP-binding pocket [chemical binding]; other site
364254004033	homodimer interface [polypeptide binding]; other site
364254004034	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
364254004035	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
364254004036	ligand binding site; other site
364254004037	oligomer interface; other site
364254004038	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
364254004039	dimer interface [polypeptide binding]; other site
364254004040	N-terminal domain interface [polypeptide binding]; other site
364254004041	sulfate 1 binding site; other site
364254004042	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
364254004043	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
364254004044	ligand binding site; other site
364254004045	oligomer interface; other site
364254004046	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
364254004047	dimer interface [polypeptide binding]; other site
364254004048	N-terminal domain interface [polypeptide binding]; other site
364254004049	glycogen branching enzyme; Provisional; Region: PRK12313
364254004050	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
364254004051	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
364254004052	active site
364254004053	catalytic site [active]
364254004054	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
364254004055	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
364254004056	homodimer interface [polypeptide binding]; other site
364254004057	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
364254004058	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
364254004059	active site
364254004060	homodimer interface [polypeptide binding]; other site
364254004061	catalytic site [active]
364254004062	glutamate dehydrogenase; Provisional; Region: PRK09414
364254004063	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
364254004064	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
364254004065	NAD(P) binding site [chemical binding]; other site
364254004066	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
364254004067	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
364254004068	NAD(P) binding site [chemical binding]; other site
364254004069	catalytic residues [active]
364254004070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254004071	Coenzyme A binding pocket [chemical binding]; other site
364254004072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004073	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004074	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
364254004075	MgtE intracellular N domain; Region: MgtE_N; cl15244
364254004076	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
364254004077	Divalent cation transporter; Region: MgtE; cl00786
364254004078	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
364254004079	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
364254004080	active site
364254004081	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
364254004082	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
364254004083	synthetase active site [active]
364254004084	NTP binding site [chemical binding]; other site
364254004085	metal binding site [ion binding]; metal-binding site
364254004086	DNA topoisomerase III; Provisional; Region: PRK07726
364254004087	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
364254004088	active site
364254004089	putative interdomain interaction site [polypeptide binding]; other site
364254004090	putative metal-binding site [ion binding]; other site
364254004091	putative nucleotide binding site [chemical binding]; other site
364254004092	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
364254004093	domain I; other site
364254004094	DNA binding groove [nucleotide binding]
364254004095	phosphate binding site [ion binding]; other site
364254004096	domain II; other site
364254004097	domain III; other site
364254004098	nucleotide binding site [chemical binding]; other site
364254004099	catalytic site [active]
364254004100	domain IV; other site
364254004101	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
364254004102	maltose O-acetyltransferase; Provisional; Region: PRK10092
364254004103	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
364254004104	active site
364254004105	substrate binding site [chemical binding]; other site
364254004106	trimer interface [polypeptide binding]; other site
364254004107	CoA binding site [chemical binding]; other site
364254004108	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
364254004109	xanthine permease; Region: pbuX; TIGR03173
364254004110	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
364254004111	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254004112	active site
364254004113	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
364254004114	Predicted membrane protein [Function unknown]; Region: COG4684
364254004115	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
364254004116	Membrane transport protein; Region: Mem_trans; cl09117
364254004117	malate dehydrogenase; Provisional; Region: PRK13529
364254004118	Malic enzyme, N-terminal domain; Region: malic; pfam00390
364254004119	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
364254004120	NAD(P) binding site [chemical binding]; other site
364254004121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
364254004122	Helix-turn-helix domains; Region: HTH; cl00088
364254004123	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254004124	dimerization interface [polypeptide binding]; other site
364254004125	Helix-turn-helix domains; Region: HTH; cl00088
364254004126	Predicted transcriptional regulators [Transcription]; Region: COG1510
364254004127	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
364254004128	Helix-turn-helix domains; Region: HTH; cl00088
364254004129	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
364254004130	Ligand Binding Site [chemical binding]; other site
364254004131	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
364254004132	Helix-turn-helix domains; Region: HTH; cl00088
364254004133	Similar to hypothetical surface protein RlpA; nonfunctional due to interrupting stop codon
364254004134	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
364254004135	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
364254004136	Acetokinase family; Region: Acetate_kinase; cl01029
364254004137	propionate/acetate kinase; Provisional; Region: PRK12379
364254004138	maltose O-acetyltransferase; Provisional; Region: PRK10092
364254004139	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
364254004140	putative trimer interface [polypeptide binding]; other site
364254004141	putative CoA binding site [chemical binding]; other site
364254004142	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
364254004143	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
364254004144	transmembrane helices; other site
364254004145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004146	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
364254004147	fumarate hydratase; Reviewed; Region: fumC; PRK00485
364254004148	Class II fumarases; Region: Fumarase_classII; cd01362
364254004149	active site
364254004150	tetramer interface [polypeptide binding]; other site
364254004151	Protein of unknown function (DUF454); Region: DUF454; cl01063
364254004152	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
364254004153	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254004154	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
364254004155	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
364254004156	ArsC family; Region: ArsC; pfam03960
364254004157	putative catalytic residues [active]
364254004158	thiol/disulfide switch; other site
364254004159	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
364254004160	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
364254004161	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
364254004162	ATP cone domain; Region: ATP-cone; pfam03477
364254004163	Class III ribonucleotide reductase; Region: RNR_III; cd01675
364254004164	effector binding site; other site
364254004165	active site
364254004166	Zn binding site [ion binding]; other site
364254004167	glycine loop; other site
364254004168	Protein of unknown function (DUF436); Region: DUF436; cl01860
364254004169	Predicted acetyltransferase [General function prediction only]; Region: COG3153
364254004170	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254004171	Coenzyme A binding pocket [chemical binding]; other site
364254004172	MucBP domain; Region: MucBP; pfam06458
364254004173	MucBP domain; Region: MucBP; pfam06458
364254004174	MucBP domain; Region: MucBP; pfam06458
364254004175	MucBP domain; Region: MucBP; pfam06458
364254004176	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
364254004177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
364254004178	Coenzyme A binding pocket [chemical binding]; other site
364254004179	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
364254004180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254004181	non-specific DNA binding site [nucleotide binding]; other site
364254004182	salt bridge; other site
364254004183	sequence-specific DNA binding site [nucleotide binding]; other site
364254004184	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
364254004185	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004186	TRAM domain; Region: TRAM; cl01282
364254004187	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
364254004188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
364254004189	S-adenosylmethionine binding site [chemical binding]; other site
364254004190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004191	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004192	putative lipid kinase; Reviewed; Region: PRK13055
364254004193	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
364254004194	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
364254004195	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
364254004196	GatB domain; Region: GatB_Yqey; cl11497
364254004197	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
364254004198	Amidase; Region: Amidase; cl11426
364254004199	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
364254004200	CamS sex pheromone cAM373 precursor; Region: CamS; cl11554
364254004201	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
364254004202	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
364254004203	nucleotide binding pocket [chemical binding]; other site
364254004204	K-X-D-G motif; other site
364254004205	catalytic site [active]
364254004206	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
364254004207	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
364254004208	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
364254004209	Dimer interface [polypeptide binding]; other site
364254004210	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
364254004211	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004212	Family description; Region: UvrD_C_2; cl15862
364254004213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004214	ATP-grasp domain; Region: ATP-grasp_4; cl03087
364254004215	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
364254004216	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
364254004217	dimer interface [polypeptide binding]; other site
364254004218	putative anticodon binding site; other site
364254004219	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
364254004220	motif 1; other site
364254004221	active site
364254004222	motif 2; other site
364254004223	motif 3; other site
364254004224	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
364254004225	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
364254004226	FMN binding site [chemical binding]; other site
364254004227	active site
364254004228	catalytic residues [active]
364254004229	substrate binding site [chemical binding]; other site
364254004230	Similar to 33 kDa chaperonin; nonfunctional due to interrupting stop codon
364254004231	FtsH Extracellular; Region: FtsH_ext; pfam06480
364254004232	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
364254004233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
364254004234	Walker A motif; other site
364254004235	ATP binding site [chemical binding]; other site
364254004236	Walker B motif; other site
364254004237	arginine finger; other site
364254004238	Peptidase family M41; Region: Peptidase_M41; pfam01434
364254004239	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254004240	active site
364254004241	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
364254004242	Ligand Binding Site [chemical binding]; other site
364254004243	B3/4 domain; Region: B3_4; cl11458
364254004244	hypothetical protein; Provisional; Region: PRK08582
364254004245	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
364254004246	RNA binding site [nucleotide binding]; other site
364254004247	Septum formation initiator; Region: DivIC; cl11433
364254004248	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254004249	RNA binding surface [nucleotide binding]; other site
364254004250	MatE; Region: MatE; cl10513
364254004251	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
364254004252	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
364254004253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254004254	ATP binding site [chemical binding]; other site
364254004255	putative Mg++ binding site [ion binding]; other site
364254004256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254004257	nucleotide binding region [chemical binding]; other site
364254004258	ATP-binding site [chemical binding]; other site
364254004259	TRCF domain; Region: TRCF; cl04088
364254004260	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
364254004261	putative active site [active]
364254004262	catalytic residue [active]
364254004263	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
364254004264	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
364254004265	tetramer (dimer of dimers) interface [polypeptide binding]; other site
364254004266	NAD binding site [chemical binding]; other site
364254004267	dimer interface [polypeptide binding]; other site
364254004268	substrate binding site [chemical binding]; other site
364254004269	Restriction endonuclease; Region: Mrr_cat; cl00516
364254004270	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
364254004271	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
364254004272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004273	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
364254004274	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
364254004275	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
364254004276	active site
364254004277	HIGH motif; other site
364254004278	dimer interface [polypeptide binding]; other site
364254004279	KMSKS motif; other site
364254004280	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
364254004281	RNA binding surface [nucleotide binding]; other site
364254004282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
364254004283	metal binding site 2 [ion binding]; metal-binding site
364254004284	putative DNA binding helix; other site
364254004285	metal binding site 1 [ion binding]; metal-binding site
364254004286	dimer interface [polypeptide binding]; other site
364254004287	structural Zn2+ binding site [ion binding]; other site
364254004288	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
364254004289	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
364254004290	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
364254004291	Walker A/P-loop; other site
364254004292	ATP binding site [chemical binding]; other site
364254004293	Q-loop/lid; other site
364254004294	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004295	ABC transporter signature motif; other site
364254004296	Walker B; other site
364254004297	D-loop; other site
364254004298	H-loop/switch region; other site
364254004299	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
364254004300	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
364254004301	active site
364254004302	metal binding site [ion binding]; metal-binding site
364254004303	DNA binding site [nucleotide binding]
364254004304	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
364254004305	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
364254004306	putative peptidoglycan binding site; other site
364254004307	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
364254004308	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
364254004309	PYR/PP interface [polypeptide binding]; other site
364254004310	dimer interface [polypeptide binding]; other site
364254004311	tetramer interface [polypeptide binding]; other site
364254004312	TPP binding site [chemical binding]; other site
364254004313	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
364254004314	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
364254004315	TPP-binding site [chemical binding]; other site
364254004316	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
364254004317	Similar to transcriptional regulator, TetR family; nonfunctional due to frameshift
364254004318	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
364254004319	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
364254004320	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
364254004321	Walker A/P-loop; other site
364254004322	ATP binding site [chemical binding]; other site
364254004323	Q-loop/lid; other site
364254004324	ABC transporter signature motif; other site
364254004325	Walker B; other site
364254004326	D-loop; other site
364254004327	H-loop/switch region; other site
364254004328	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
364254004329	dimer interface [polypeptide binding]; other site
364254004330	FMN binding site [chemical binding]; other site
364254004331	NADPH bind site [chemical binding]; other site
364254004332	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
364254004333	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004334	Family description; Region: UvrD_C_2; cl15862
364254004335	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
364254004336	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
364254004337	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
364254004338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004339	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
364254004340	Similar to conserved hypothetical protein; nonfunctional due to frameshift and interrupting stop codon
364254004341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004342	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004343	ABC-2 type transporter; Region: ABC2_membrane; cl11417
364254004344	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
364254004345	ABC-2 type transporter; Region: ABC2_membrane; cl11417
364254004346	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
364254004347	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
364254004348	Walker A/P-loop; other site
364254004349	ATP binding site [chemical binding]; other site
364254004350	Q-loop/lid; other site
364254004351	ABC transporter signature motif; other site
364254004352	Walker B; other site
364254004353	D-loop; other site
364254004354	H-loop/switch region; other site
364254004355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
364254004356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004357	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004358	Phospholipid methyltransferase; Region: PEMT; cl00763
364254004359	Similar to transposase ISLasa10, IS256 family; nonfunctional due to truncation
364254004360	Fic/DOC family; Region: Fic; cl00960
364254004361	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
364254004362	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004363	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
364254004364	Walker A/P-loop; other site
364254004365	ATP binding site [chemical binding]; other site
364254004366	Q-loop/lid; other site
364254004367	Similar to transposase ISLasa11, IS30 family; nonfunctional due to frameshift
364254004368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004369	short chain dehydrogenase; Provisional; Region: PRK06197
364254004370	NAD(P) binding site [chemical binding]; other site
364254004371	active site
364254004372	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
364254004373	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
364254004374	putative active site [active]
364254004375	putative metal binding site [ion binding]; other site
364254004376	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
364254004377	Similar to hydrolase, TatD family; nonfunctional due to frameshift
364254004378	Similar to alcohol dehydrogenase; nonfunctional due to interrupting stop codon
364254004379	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
364254004380	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
364254004381	23S rRNA interface [nucleotide binding]; other site
364254004382	L3 interface [polypeptide binding]; other site
364254004383	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
364254004384	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
364254004385	dimerization interface 3.5A [polypeptide binding]; other site
364254004386	active site
364254004387	Cobalt transport protein; Region: CbiQ; cl00463
364254004388	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
364254004389	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
364254004390	Walker A/P-loop; other site
364254004391	ATP binding site [chemical binding]; other site
364254004392	Q-loop/lid; other site
364254004393	ABC transporter signature motif; other site
364254004394	Walker B; other site
364254004395	D-loop; other site
364254004396	H-loop/switch region; other site
364254004397	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
364254004398	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
364254004399	Walker A/P-loop; other site
364254004400	ATP binding site [chemical binding]; other site
364254004401	Q-loop/lid; other site
364254004402	ABC transporter signature motif; other site
364254004403	Walker B; other site
364254004404	D-loop; other site
364254004405	H-loop/switch region; other site
364254004406	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
364254004407	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
364254004408	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
364254004409	alphaNTD homodimer interface [polypeptide binding]; other site
364254004410	alphaNTD - beta interaction site [polypeptide binding]; other site
364254004411	alphaNTD - beta' interaction site [polypeptide binding]; other site
364254004412	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
364254004413	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
364254004414	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
364254004415	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
364254004416	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
364254004417	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
364254004418	rRNA binding site [nucleotide binding]; other site
364254004419	predicted 30S ribosome binding site; other site
364254004420	adenylate kinase; Reviewed; Region: adk; PRK00279
364254004421	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
364254004422	AMP-binding site [chemical binding]; other site
364254004423	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
364254004424	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
364254004425	SecY translocase; Region: SecY; pfam00344
364254004426	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
364254004427	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
364254004428	23S rRNA binding site [nucleotide binding]; other site
364254004429	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
364254004430	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
364254004431	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
364254004432	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
364254004433	5S rRNA interface [nucleotide binding]; other site
364254004434	L27 interface [polypeptide binding]; other site
364254004435	23S rRNA interface [nucleotide binding]; other site
364254004436	L5 interface [polypeptide binding]; other site
364254004437	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
364254004438	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
364254004439	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
364254004440	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
364254004441	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
364254004442	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
364254004443	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
364254004444	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
364254004445	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
364254004446	KOW motif; Region: KOW; cl00354
364254004447	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
364254004448	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
364254004449	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
364254004450	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
364254004451	23S rRNA interface [nucleotide binding]; other site
364254004452	5S rRNA interface [nucleotide binding]; other site
364254004453	putative antibiotic binding site [chemical binding]; other site
364254004454	L25 interface [polypeptide binding]; other site
364254004455	L27 interface [polypeptide binding]; other site
364254004456	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
364254004457	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
364254004458	G-X-X-G motif; other site
364254004459	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
364254004460	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
364254004461	putative translocon binding site; other site
364254004462	protein-rRNA interface [nucleotide binding]; other site
364254004463	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
364254004464	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
364254004465	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
364254004466	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
364254004467	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
364254004468	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
364254004469	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
364254004470	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
364254004471	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
364254004472	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
364254004473	HflX GTPase family; Region: HflX; cd01878
364254004474	G1 box; other site
364254004475	GTP/Mg2+ binding site [chemical binding]; other site
364254004476	Switch I region; other site
364254004477	G2 box; other site
364254004478	G3 box; other site
364254004479	Switch II region; other site
364254004480	G4 box; other site
364254004481	G5 box; other site
364254004482	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
364254004483	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
364254004484	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
364254004485	putative active site [active]
364254004486	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
364254004487	tetramer (dimer of dimers) interface [polypeptide binding]; other site
364254004488	active site
364254004489	dimer interface [polypeptide binding]; other site
364254004490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004491	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
364254004492	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254004493	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
364254004494	Spore germination protein; Region: Spore_permease; cl15802
364254004495	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
364254004496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254004497	dimer interface [polypeptide binding]; other site
364254004498	conserved gate region; other site
364254004499	putative PBP binding loops; other site
364254004500	ABC-ATPase subunit interface; other site
364254004501	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
364254004502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254004503	dimer interface [polypeptide binding]; other site
364254004504	conserved gate region; other site
364254004505	putative PBP binding loops; other site
364254004506	ABC-ATPase subunit interface; other site
364254004507	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254004508	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254004509	substrate binding pocket [chemical binding]; other site
364254004510	membrane-bound complex binding site; other site
364254004511	hinge residues; other site
364254004512	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
364254004513	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
364254004514	Walker A/P-loop; other site
364254004515	ATP binding site [chemical binding]; other site
364254004516	Q-loop/lid; other site
364254004517	ABC transporter signature motif; other site
364254004518	Walker B; other site
364254004519	D-loop; other site
364254004520	H-loop/switch region; other site
364254004521	ferric uptake regulator; Provisional; Region: fur; PRK09462
364254004522	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
364254004523	metal binding site 2 [ion binding]; metal-binding site
364254004524	putative DNA binding helix; other site
364254004525	metal binding site 1 [ion binding]; metal-binding site
364254004526	dimer interface [polypeptide binding]; other site
364254004527	structural Zn2+ binding site [ion binding]; other site
364254004528	amino acid transporter; Region: 2A0306; TIGR00909
364254004529	Spore germination protein; Region: Spore_permease; cl15802
364254004530	Spore germination protein; Region: Spore_permease; cl15802
364254004531	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
364254004532	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
364254004533	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
364254004534	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
364254004535	active site
364254004536	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
364254004537	PLD-like domain; Region: PLDc_2; pfam13091
364254004538	putative homodimer interface [polypeptide binding]; other site
364254004539	putative active site [active]
364254004540	catalytic site [active]
364254004541	DEAD-like helicases superfamily; Region: DEXDc; smart00487
364254004542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
364254004543	ATP binding site [chemical binding]; other site
364254004544	putative Mg++ binding site [ion binding]; other site
364254004545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
364254004546	nucleotide binding region [chemical binding]; other site
364254004547	Predicted helicase [General function prediction only]; Region: COG4889
364254004548	ATP-binding site [chemical binding]; other site
364254004549	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
364254004550	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
364254004551	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
364254004552	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
364254004553	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
364254004554	Domain of unknown function DUF21; Region: DUF21; pfam01595
364254004555	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
364254004556	Transporter associated domain; Region: CorC_HlyC; cl08393
364254004557	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
364254004558	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
364254004559	active site
364254004560	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
364254004561	FtsX-like permease family; Region: FtsX; cl15850
364254004562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
364254004563	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
364254004564	Walker A/P-loop; other site
364254004565	ATP binding site [chemical binding]; other site
364254004566	Q-loop/lid; other site
364254004567	ABC transporter signature motif; other site
364254004568	Walker B; other site
364254004569	D-loop; other site
364254004570	H-loop/switch region; other site
364254004571	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
364254004572	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
364254004573	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
364254004574	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
364254004575	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
364254004576	MatE; Region: MatE; cl10513
364254004577	MatE; Region: MatE; cl10513
364254004578	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
364254004579	dimer interface [polypeptide binding]; other site
364254004580	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
364254004581	metal binding site [ion binding]; metal-binding site
364254004582	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
364254004583	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
364254004584	active site
364254004585	trimer interface [polypeptide binding]; other site
364254004586	allosteric site; other site
364254004587	active site lid [active]
364254004588	hexamer (dimer of trimers) interface [polypeptide binding]; other site
364254004589	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
364254004590	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
364254004591	active site
364254004592	dimer interface [polypeptide binding]; other site
364254004593	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
364254004594	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
364254004595	metal binding site [ion binding]; metal-binding site
364254004596	dimer interface [polypeptide binding]; other site
364254004597	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
364254004598	classical (c) SDRs; Region: SDR_c; cd05233
364254004599	NAD(P) binding site [chemical binding]; other site
364254004600	active site
364254004601	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
364254004602	QueT transporter; Region: QueT; cl01932
364254004603	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004604	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004605	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
364254004606	CrcB-like protein; Region: CRCB; cl09114
364254004607	CrcB-like protein; Region: CRCB; cl09114
364254004608	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
364254004609	catalytic residues [active]
364254004610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254004611	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
364254004612	active site
364254004613	motif I; other site
364254004614	motif II; other site
364254004615	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254004616	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254004617	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
364254004618	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
364254004619	Uncharacterized conserved protein [Function unknown]; Region: COG2966
364254004620	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
364254004621	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
364254004622	DNA-binding site [nucleotide binding]; DNA binding site
364254004623	RNA-binding motif; other site
364254004624	Helix-turn-helix domains; Region: HTH; cl00088
364254004625	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
364254004626	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
364254004627	FeoA domain; Region: FeoA; cl00838
364254004628	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
364254004629	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
364254004630	active site
364254004631	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
364254004632	active site
364254004633	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
364254004634	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
364254004635	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
364254004636	AzlC protein; Region: AzlC; cl00570
364254004637	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
364254004638	active site
364254004639	putative catalytic site [active]
364254004640	DNA binding site [nucleotide binding]
364254004641	putative phosphate binding site [ion binding]; other site
364254004642	metal binding site A [ion binding]; metal-binding site
364254004643	AP binding site [nucleotide binding]; other site
364254004644	metal binding site B [ion binding]; metal-binding site
364254004645	Predicted membrane protein [Function unknown]; Region: COG1511
364254004646	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
364254004647	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
364254004648	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
364254004649	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
364254004650	ABC-2 type transporter; Region: ABC2_membrane; cl11417
364254004651	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
364254004652	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
364254004653	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
364254004654	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
364254004655	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254004656	catalytic core [active]
364254004657	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254004658	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
364254004659	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
364254004660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254004661	homodimer interface [polypeptide binding]; other site
364254004662	catalytic residue [active]
364254004663	Domain of unknown function DUF20; Region: UPF0118; pfam01594
364254004664	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
364254004665	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
364254004666	EamA-like transporter family; Region: EamA; cl01037
364254004667	EamA-like transporter family; Region: EamA; cl01037
364254004668	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
364254004669	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254004670	motif II; other site
364254004671	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
364254004672	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
364254004673	active site
364254004674	catalytic residues [active]
364254004675	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254004676	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
364254004677	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
364254004678	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
364254004679	Helix-turn-helix domains; Region: HTH; cl00088
364254004680	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
364254004681	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
364254004682	NAD binding site [chemical binding]; other site
364254004683	homodimer interface [polypeptide binding]; other site
364254004684	active site
364254004685	substrate binding site [chemical binding]; other site
364254004686	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
364254004687	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
364254004688	DNA-binding site [nucleotide binding]; DNA binding site
364254004689	UTRA domain; Region: UTRA; cl01230
364254004690	putative phosphoketolase; Provisional; Region: PRK05261
364254004691	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
364254004692	TPP-binding site; other site
364254004693	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
364254004694	XFP C-terminal domain; Region: XFP_C; pfam09363
364254004695	Isochorismatase family; Region: Isochorismatase; pfam00857
364254004696	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
364254004697	catalytic triad [active]
364254004698	conserved cis-peptide bond; other site
364254004699	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254004700	catalytic core [active]
364254004701	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
364254004702	HPr interaction site; other site
364254004703	glycerol kinase (GK) interaction site [polypeptide binding]; other site
364254004704	active site
364254004705	phosphorylation site [posttranslational modification]
364254004706	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
364254004707	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
364254004708	active site turn [active]
364254004709	phosphorylation site [posttranslational modification]
364254004710	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254004711	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
364254004712	DNA-binding site [nucleotide binding]; DNA binding site
364254004713	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
364254004714	UTRA domain; Region: UTRA; cl01230
364254004715	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
364254004716	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
364254004717	Ca binding site [ion binding]; other site
364254004718	active site
364254004719	catalytic site [active]
364254004720	drug efflux system protein MdtG; Provisional; Region: PRK09874
364254004721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254004722	putative substrate translocation pore; other site
364254004723	Similar to conserved hypothetical protein; nonfunctional due to frameshift
364254004724	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004725	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004726	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
364254004727	amidase catalytic site [active]
364254004728	Zn binding residues [ion binding]; other site
364254004729	substrate binding site [chemical binding]; other site
364254004730	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
364254004731	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004732	homoserine kinase; Provisional; Region: PRK01212
364254004733	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
364254004734	homoserine dehydrogenase; Provisional; Region: PRK06349
364254004735	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004736	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
364254004737	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
364254004738	ApbE family; Region: ApbE; cl00643
364254004739	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
364254004740	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
364254004741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254004742	catalytic residue [active]
364254004743	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
364254004744	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004745	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004746	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004747	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
364254004748	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
364254004749	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
364254004750	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
364254004751	Similar to conserved hypothetical protein; nonfunctional due to frameshift
364254004752	Similar to hpothetical membrane spanning protein; nonfunctional due to frameshift
364254004753	OpgC protein; Region: OpgC_C; cl00792
364254004754	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
364254004755	active site
364254004756	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
364254004757	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254004758	PAS domain; Region: PAS_10; pfam13596
364254004759	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254004760	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
364254004761	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
364254004762	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
364254004763	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
364254004764	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
364254004765	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696
364254004766	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
364254004767	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
364254004768	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004769	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004770	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
364254004771	putative active site [active]
364254004772	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
364254004773	GMP synthase; Reviewed; Region: guaA; PRK00074
364254004774	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
364254004775	AMP/PPi binding site [chemical binding]; other site
364254004776	candidate oxyanion hole; other site
364254004777	catalytic triad [active]
364254004778	potential glutamine specificity residues [chemical binding]; other site
364254004779	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
364254004780	ATP Binding subdomain [chemical binding]; other site
364254004781	Dimerization subdomain; other site
364254004782	pantothenate kinase; Provisional; Region: PRK05439
364254004783	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
364254004784	ATP-binding site [chemical binding]; other site
364254004785	CoA-binding site [chemical binding]; other site
364254004786	Mg2+-binding site [ion binding]; other site
364254004787	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
364254004788	catalytic triad [active]
364254004789	oxyanion hole [active]
364254004790	active site
364254004791	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
364254004792	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
364254004793	Walker A/P-loop; other site
364254004794	ATP binding site [chemical binding]; other site
364254004795	Q-loop/lid; other site
364254004796	ABC transporter signature motif; other site
364254004797	Walker B; other site
364254004798	D-loop; other site
364254004799	H-loop/switch region; other site
364254004800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254004801	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254004802	substrate binding pocket [chemical binding]; other site
364254004803	membrane-bound complex binding site; other site
364254004804	hinge residues; other site
364254004805	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
364254004806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254004807	dimer interface [polypeptide binding]; other site
364254004808	conserved gate region; other site
364254004809	putative PBP binding loops; other site
364254004810	ABC-ATPase subunit interface; other site
364254004811	inner membrane transporter YjeM; Provisional; Region: PRK15238
364254004812	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
364254004813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254004814	putative substrate translocation pore; other site
364254004815	Major Facilitator Superfamily; Region: MFS_1; pfam07690
364254004816	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
364254004817	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004818	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
364254004819	Peptidase family M23; Region: Peptidase_M23; pfam01551
364254004820	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
364254004821	MatE; Region: MatE; cl10513
364254004822	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
364254004823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254004824	UDP-galactopyranose mutase; Region: GLF; pfam03275
364254004825	Core-2/I-Branching enzyme; Region: Branch; pfam02485
364254004826	Bacterial sugar transferase; Region: Bac_transf; cl00939
364254004827	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
364254004828	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
364254004829	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
364254004830	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
364254004831	Nucleotide binding site [chemical binding]; other site
364254004832	Chain length determinant protein; Region: Wzz; cl15801
364254004833	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
364254004834	Similar to glycerol-3-phosphate cytidylyltransferase; nonfunctional due to frameshift
364254004835	Similar to lipooligosaccharide cholinephosphotransferase; nonfunctional due to frameshift
364254004836	MatE; Region: MatE; cl10513
364254004837	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
364254004838	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
364254004839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254004840	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
364254004841	putative ADP-binding pocket [chemical binding]; other site
364254004842	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
364254004843	active site
364254004844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
364254004845	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
364254004846	putative ADP-binding pocket [chemical binding]; other site
364254004847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254004848	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254004849	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
364254004850	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004851	Walker A motif; other site
364254004852	ATP binding site [chemical binding]; other site
364254004853	Family description; Region: UvrD_C_2; cl15862
364254004854	AAA ATPase domain; Region: AAA_15; pfam13175
364254004855	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
364254004856	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
364254004857	putative active site [active]
364254004858	putative metal-binding site [ion binding]; other site
364254004859	Predicted membrane protein [Function unknown]; Region: COG4640
364254004860	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
364254004861	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
364254004862	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
364254004863	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
364254004864	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
364254004865	NADP binding site [chemical binding]; other site
364254004866	active site
364254004867	putative substrate binding site [chemical binding]; other site
364254004868	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
364254004869	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
364254004870	NAD binding site [chemical binding]; other site
364254004871	substrate binding site [chemical binding]; other site
364254004872	homodimer interface [polypeptide binding]; other site
364254004873	active site
364254004874	Cupin domain; Region: Cupin_2; cl09118
364254004875	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
364254004876	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
364254004877	substrate binding site; other site
364254004878	tetramer interface; other site
364254004879	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
364254004880	active site
364254004881	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
364254004882	CAAX protease self-immunity; Region: Abi; cl00558
364254004883	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
364254004884	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
364254004885	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
364254004886	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
364254004887	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254004888	motif II; other site
364254004889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254004890	Major Facilitator Superfamily; Region: MFS_1; pfam07690
364254004891	putative substrate translocation pore; other site
364254004892	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
364254004893	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
364254004894	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
364254004895	DNA binding residues [nucleotide binding]
364254004896	putative dimer interface [polypeptide binding]; other site
364254004897	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254004898	Site-specific recombinase; Region: SpecificRecomb; cl15411
364254004899	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
364254004900	dimer interface [polypeptide binding]; other site
364254004901	substrate binding site [chemical binding]; other site
364254004902	ATP binding site [chemical binding]; other site
364254004903	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
364254004904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004905	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
364254004906	Walker A/P-loop; other site
364254004907	ATP binding site [chemical binding]; other site
364254004908	Q-loop/lid; other site
364254004909	ABC transporter signature motif; other site
364254004910	Walker B; other site
364254004911	D-loop; other site
364254004912	H-loop/switch region; other site
364254004913	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
364254004914	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
364254004915	metal binding site [ion binding]; metal-binding site
364254004916	Similar to transposase ISLasa3b, IS200 family; nonfunctional due to frameshift
364254004917	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
364254004918	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
364254004919	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
364254004920	GTP-binding protein YchF; Reviewed; Region: PRK09601
364254004921	YchF GTPase; Region: YchF; cd01900
364254004922	G1 box; other site
364254004923	GTP/Mg2+ binding site [chemical binding]; other site
364254004924	Switch I region; other site
364254004925	G2 box; other site
364254004926	Switch II region; other site
364254004927	G3 box; other site
364254004928	G4 box; other site
364254004929	G5 box; other site
364254004930	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
364254004931	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
364254004932	ParB-like partition proteins; Region: parB_part; TIGR00180
364254004933	ParB-like nuclease domain; Region: ParBc; cl02129
364254004934	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254004935	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
364254004936	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
364254004937	P-loop; other site
364254004938	Magnesium ion binding site [ion binding]; other site
364254004939	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
364254004940	Magnesium ion binding site [ion binding]; other site
364254004941	ParB-like partition proteins; Region: parB_part; TIGR00180
364254004942	ParB-like nuclease domain; Region: ParBc; cl02129
364254004943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
364254004944	Methyltransferase domain; Region: Methyltransf_31; pfam13847
364254004945	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
364254004946	tetramer (dimer of dimers) interface [polypeptide binding]; other site
364254004947	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
364254004948	NAD binding site [chemical binding]; other site
364254004949	dimer interface [polypeptide binding]; other site
364254004950	substrate binding site [chemical binding]; other site
364254004951	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
364254004952	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
364254004953	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
364254004954	putative active site [active]
364254004955	catalytic site [active]
364254004956	putative metal binding site [ion binding]; other site
364254004957	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
364254004958	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
364254004959	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
364254004960	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
364254004961	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254004962	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
364254004963	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
364254004964	DJ-1 family protein; Region: not_thiJ; TIGR01383
364254004965	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
364254004966	conserved cys residue [active]
364254004967	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
364254004968	active site
364254004969	catalytic site [active]
364254004970	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
364254004971	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004972	Family description; Region: UvrD_C_2; cl15862
364254004973	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
364254004974	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
364254004975	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
364254004976	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
364254004977	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
364254004978	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
364254004979	active site
364254004980	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
364254004981	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
364254004982	putative catalytic cysteine [active]
364254004983	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
364254004984	nucleotide binding site [chemical binding]; other site
364254004985	homotetrameric interface [polypeptide binding]; other site
364254004986	putative phosphate binding site [ion binding]; other site
364254004987	putative allosteric binding site; other site
364254004988	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
364254004989	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
364254004990	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
364254004991	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
364254004992	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254004993	Walker A/P-loop; other site
364254004994	ATP binding site [chemical binding]; other site
364254004995	Q-loop/lid; other site
364254004996	ABC transporter signature motif; other site
364254004997	Walker B; other site
364254004998	D-loop; other site
364254004999	H-loop/switch region; other site
364254005000	Predicted transcriptional regulators [Transcription]; Region: COG1725
364254005001	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
364254005002	DNA-binding site [nucleotide binding]; DNA binding site
364254005003	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
364254005004	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
364254005005	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
364254005006	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
364254005007	active site
364254005008	phosphorylation site [posttranslational modification]
364254005009	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
364254005010	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
364254005011	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
364254005012	active site
364254005013	P-loop; other site
364254005014	phosphorylation site [posttranslational modification]
364254005015	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
364254005016	active site
364254005017	P-loop; other site
364254005018	phosphorylation site [posttranslational modification]
364254005019	Integral membrane protein TerC family; Region: TerC; cl10468
364254005020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254005021	non-specific DNA binding site [nucleotide binding]; other site
364254005022	salt bridge; other site
364254005023	sequence-specific DNA binding site [nucleotide binding]; other site
364254005024	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
364254005025	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
364254005026	substrate binding pocket [chemical binding]; other site
364254005027	membrane-bound complex binding site; other site
364254005028	hinge residues; other site
364254005029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
364254005030	Transposase; Region: DDE_Tnp_ISL3; pfam01610
364254005031	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
364254005032	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
364254005033	Walker A/P-loop; other site
364254005034	ATP binding site [chemical binding]; other site
364254005035	Q-loop/lid; other site
364254005036	ABC transporter signature motif; other site
364254005037	Walker B; other site
364254005038	D-loop; other site
364254005039	H-loop/switch region; other site
364254005040	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
364254005041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254005042	dimer interface [polypeptide binding]; other site
364254005043	conserved gate region; other site
364254005044	putative PBP binding loops; other site
364254005045	ABC-ATPase subunit interface; other site
364254005046	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
364254005047	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
364254005048	glutaminase active site [active]
364254005049	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
364254005050	dimer interface [polypeptide binding]; other site
364254005051	active site
364254005052	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
364254005053	dimer interface [polypeptide binding]; other site
364254005054	active site
364254005055	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
364254005056	Helix-turn-helix domains; Region: HTH; cl00088
364254005057	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
364254005058	active site
364254005059	P-loop; other site
364254005060	phosphorylation site [posttranslational modification]
364254005061	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
364254005062	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
364254005063	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
364254005064	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
364254005065	amphipathic channel; other site
364254005066	Asn-Pro-Ala signature motifs; other site
364254005067	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
364254005068	DAK2 domain; Region: Dak2; cl03685
364254005069	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
364254005070	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
364254005071	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
364254005072	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
364254005073	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
364254005074	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
364254005075	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
364254005076	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
364254005077	Similar to nitroreductase family protein; nonfunctional due to frameshift
364254005078	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
364254005079	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
364254005080	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254005081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
364254005082	dimerization interface [polypeptide binding]; other site
364254005083	putative DNA binding site [nucleotide binding]; other site
364254005084	putative Zn2+ binding site [ion binding]; other site
364254005085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254005086	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
364254005087	Substrate-binding site [chemical binding]; other site
364254005088	Substrate specificity [chemical binding]; other site
364254005089	TIR domain; Region: TIR_2; cl15770
364254005090	AzlC protein; Region: AzlC; cl00570
364254005091	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
364254005092	Transcriptional regulators [Transcription]; Region: MarR; COG1846
364254005093	Helix-turn-helix domains; Region: HTH; cl00088
364254005094	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
364254005095	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
364254005096	G-X-X-G motif; other site
364254005097	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
364254005098	RxxxH motif; other site
364254005099	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
364254005100	Int/Topo IB signature motif; other site
364254005101	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
364254005102	non-specific DNA binding site [nucleotide binding]; other site
364254005103	salt bridge; other site
364254005104	sequence-specific DNA binding site [nucleotide binding]; other site
364254005105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
364254005106	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
364254005107	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
364254005108	polymerase nucleotide-binding site; other site
364254005109	DNA-binding residues [nucleotide binding]; DNA binding site
364254005110	nucleotide binding site [chemical binding]; other site
364254005111	primase nucleotide-binding site [nucleotide binding]; other site
364254005112	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
364254005113	D5 N terminal like; Region: D5_N; cl07360
364254005114	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
364254005115	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
364254005116	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254005117	Helix-turn-helix domains; Region: HTH; cl00088
364254005118	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
364254005119	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
364254005120	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
364254005121	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
364254005122	active site
364254005123	Zn binding site [ion binding]; other site
364254005124	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
364254005125	homodimer interface [polypeptide binding]; other site
364254005126	substrate-cofactor binding pocket; other site
364254005127	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254005128	catalytic residue [active]
364254005129	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
364254005130	SdpI/YhfL protein family; Region: SdpI; pfam13630
364254005131	Similar to pyridoxine kinase; nonfunctional due to frameshift
364254005132	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
364254005133	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
364254005134	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
364254005135	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
364254005136	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
364254005137	FtsX-like permease family; Region: FtsX; cl15850
364254005138	FtsX-like permease family; Region: FtsX; cl15850
364254005139	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
364254005140	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
364254005141	Walker A/P-loop; other site
364254005142	ATP binding site [chemical binding]; other site
364254005143	Q-loop/lid; other site
364254005144	ABC transporter signature motif; other site
364254005145	Walker B; other site
364254005146	D-loop; other site
364254005147	H-loop/switch region; other site
364254005148	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254005149	Helix-turn-helix domains; Region: HTH; cl00088
364254005150	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
364254005151	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
364254005152	AAA domain; Region: AAA_27; pfam13514
364254005153	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
364254005154	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
364254005155	active site
364254005156	metal binding site [ion binding]; metal-binding site
364254005157	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
364254005158	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
364254005159	active site
364254005160	catalytic tetrad [active]
364254005161	Helix-turn-helix domains; Region: HTH; cl00088
364254005162	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
364254005163	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
364254005164	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
364254005165	Walker A/P-loop; other site
364254005166	ATP binding site [chemical binding]; other site
364254005167	Q-loop/lid; other site
364254005168	ABC transporter signature motif; other site
364254005169	Walker B; other site
364254005170	D-loop; other site
364254005171	H-loop/switch region; other site
364254005172	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
364254005173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
364254005174	putative substrate translocation pore; other site
364254005175	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
364254005176	dimer interface [polypeptide binding]; other site
364254005177	catalytic triad [active]
364254005178	peroxidatic and resolving cysteines [active]
364254005179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
364254005180	Helix-turn-helix domains; Region: HTH; cl00088
364254005181	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
364254005182	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
364254005183	LytTr DNA-binding domain; Region: LytTR; cl04498
364254005184	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
364254005185	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
364254005186	S-methylmethionine transporter; Provisional; Region: PRK11387
364254005187	Spore germination protein; Region: Spore_permease; cl15802
364254005188	Phosphate-starvation-inducible E; Region: PsiE; cl01264
364254005189	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
364254005190	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
364254005191	Walker A/P-loop; other site
364254005192	ATP binding site [chemical binding]; other site
364254005193	Q-loop/lid; other site
364254005194	ABC transporter signature motif; other site
364254005195	Walker B; other site
364254005196	D-loop; other site
364254005197	H-loop/switch region; other site
364254005198	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
364254005199	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
364254005200	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
364254005201	Walker A/P-loop; other site
364254005202	ATP binding site [chemical binding]; other site
364254005203	Q-loop/lid; other site
364254005204	ABC transporter signature motif; other site
364254005205	Walker B; other site
364254005206	D-loop; other site
364254005207	H-loop/switch region; other site
364254005208	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
364254005209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254005210	dimer interface [polypeptide binding]; other site
364254005211	conserved gate region; other site
364254005212	putative PBP binding loops; other site
364254005213	ABC-ATPase subunit interface; other site
364254005214	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
364254005215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
364254005216	dimer interface [polypeptide binding]; other site
364254005217	conserved gate region; other site
364254005218	putative PBP binding loops; other site
364254005219	ABC-ATPase subunit interface; other site
364254005220	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
364254005221	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
364254005222	peptide binding site [polypeptide binding]; other site
364254005223	putative transport protein YifK; Provisional; Region: PRK10746
364254005224	elongation factor P; Validated; Region: PRK00529
364254005225	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
364254005226	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
364254005227	RNA binding site [nucleotide binding]; other site
364254005228	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
364254005229	RNA binding site [nucleotide binding]; other site
364254005230	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
364254005231	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
364254005232	active site
364254005233	motif I; other site
364254005234	motif II; other site
364254005235	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254005236	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
364254005237	catalytic core [active]
364254005238	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
364254005239	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
364254005240	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
364254005241	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
364254005242	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
364254005243	Glycerate kinase family; Region: Gly_kinase; cl00841
364254005244	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
364254005245	dimerization interface [polypeptide binding]; other site
364254005246	putative DNA binding site [nucleotide binding]; other site
364254005247	putative Zn2+ binding site [ion binding]; other site
364254005248	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
364254005249	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
364254005250	potential catalytic triad [active]
364254005251	conserved cys residue [active]
364254005252	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
364254005253	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
364254005254	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
364254005255	putative active site [active]
364254005256	catalytic site [active]
364254005257	putative metal binding site [ion binding]; other site
364254005258	Transcriptional regulators [Transcription]; Region: PurR; COG1609
364254005259	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
364254005260	DNA binding site [nucleotide binding]
364254005261	domain linker motif; other site
364254005262	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
364254005263	dimerization interface [polypeptide binding]; other site
364254005264	ligand binding site [chemical binding]; other site
364254005265	sodium binding site [ion binding]; other site
364254005266	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
364254005267	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
364254005268	Ca binding site [ion binding]; other site
364254005269	active site
364254005270	catalytic site [active]
364254005271	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
364254005272	active pocket/dimerization site; other site
364254005273	active site
364254005274	phosphorylation site [posttranslational modification]
364254005275	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
364254005276	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
364254005277	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
364254005278	active site
364254005279	phosphorylation site [posttranslational modification]
364254005280	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
364254005281	proposed active site lysine [active]
364254005282	conserved cys residue [active]
364254005283	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
364254005284	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
364254005285	dimer interface [polypeptide binding]; other site
364254005286	pyridoxal 5'-phosphate binding site [chemical binding]; other site
364254005287	catalytic residue [active]
364254005288	Similar to oligopeptide-binding protein oppA; nonfunctional due to truncation
364254005289	Similar to nitro/flavin reductase; nonfunctional due to truncation
364254005290	Protein of unknown function (DUF328); Region: DUF328; cl01143
364254005291	CAAX protease self-immunity; Region: Abi; cl00558
364254005292	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
364254005293	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
364254005294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
364254005295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
364254005296	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
364254005297	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
364254005298	GDP-binding site [chemical binding]; other site
364254005299	ACT binding site; other site
364254005300	IMP binding site; other site
364254005301	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
364254005302	replicative DNA helicase; Provisional; Region: PRK05748
364254005303	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
364254005304	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
364254005305	Walker A motif; other site
364254005306	ATP binding site [chemical binding]; other site
364254005307	Walker B motif; other site
364254005308	DNA binding loops [nucleotide binding]
364254005309	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
364254005310	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
364254005311	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
364254005312	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
364254005313	DHH family; Region: DHH; pfam01368
364254005314	DHHA1 domain; Region: DHHA1; pfam02272
364254005315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
364254005316	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
364254005317	putative active site [active]
364254005318	putative metal binding site [ion binding]; other site
364254005319	Transcriptional regulator [Transcription]; Region: LysR; COG0583
364254005320	Helix-turn-helix domains; Region: HTH; cl00088
364254005321	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
364254005322	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
364254005323	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
364254005324	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
364254005325	Nucleoside recognition; Region: Gate; cl00486
364254005326	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
364254005327	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
364254005328	Ribonuclease P; Region: Ribonuclease_P; cl00457
364254005329	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
362948005330	Source DNA is available from Eva McArdle at Alimentary Pharmabiotic Centre (e.mcardle@ucc.ie)
362948005331	Initiator Replication protein; Region: Rep_3; cl03080
362948005332	Helix-turn-helix domains; Region: HTH; cl00088
362948005333	Similar to 6-phospho-beta-glucosidase; nonfunctional due to frameshift
362948005334	Similar to PTS system, beta-glucoside-specific IIABC component; nonfunctional due to truncation
362948005335	Similar to beta-glucoside operon antiterminator; nonfunctional due to truncation
362948005336	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
362948005337	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948005338	P-loop; other site
362948005339	Magnesium ion binding site [ion binding]; other site
362948005340	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
362948005341	Magnesium ion binding site [ion binding]; other site
362948005342	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
362948005343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
362948005344	Probable transposase; Region: OrfB_IS605; pfam01385
362948005345	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
362948005346	Peptidase family M1; Region: Peptidase_M1; pfam01433
362948005347	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
362948005348	Zn binding site [ion binding]; other site
362948005349	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
362948005350	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
362948005351	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
362948005352	active site
362948005353	catalytic tetrad [active]
362948005354	MarC family integral membrane protein; Region: MarC; cl00919
362948005355	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
362948005356	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
362948005357	catalytic Zn binding site [ion binding]; other site
362948005358	NAD binding site [chemical binding]; other site
362948005359	structural Zn binding site [ion binding]; other site
362948005360	Predicted membrane protein [Function unknown]; Region: COG2364
362948005361	Cupin domain; Region: Cupin_2; cl09118
362948005362	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
362948005363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
362948005364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362948005365	putative substrate translocation pore; other site
362948005366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362948005367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362948005368	L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
362948005369	N- and C-terminal domain interface [polypeptide binding]; other site
362948005370	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
362948005371	active site
362948005372	catalytic site [active]
362948005373	metal binding site [ion binding]; metal-binding site
362948005374	ATP binding site [chemical binding]; other site
362948005375	carbohydrate binding site [chemical binding]; other site
362948005376	Domain of unknown function (DUF718); Region: DUF718; cl01281
362948005377	L-rhamnose isomerase; Provisional; Region: PRK01076
362948005378	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
362948005379	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
362948005380	intersubunit interface [polypeptide binding]; other site
362948005381	active site
362948005382	Zn2+ binding site [ion binding]; other site
362948005383	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
362948005384	Int/Topo IB signature motif; other site
362948005385	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
362948005386	N-terminal C2 in EEIG1 and EHBP1 proteins; Region: NT-C2; pfam10358
362948005387	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
362948005388	Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift
362948005389	Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift
362948005390	Similar to type III restriction-modification system methylation subunit; nonfunctional due to frameshift
362948005391	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
362948005392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421
362948005393	ATP binding site [chemical binding]; other site
362948005394	putative Mg++ binding site [ion binding]; other site
362948005395	stage V sporulation protein K; Region: spore_V_K; TIGR02881
362948005396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362948005397	Walker A motif; other site
362948005398	ATP binding site [chemical binding]; other site
362948005399	Walker B motif; other site
362948005400	arginine finger; other site
362948005401	stage V sporulation protein K; Region: spore_V_K; TIGR02881
362948005402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362948005403	Walker A motif; other site
362948005404	ATP binding site [chemical binding]; other site
362948005405	Walker B motif; other site
362948005406	arginine finger; other site
362948005407	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
362948005408	amino acid transporter; Region: 2A0306; TIGR00909
362948005409	Spore germination protein; Region: Spore_permease; cl15802
362948005410	Spore germination protein; Region: Spore_permease; cl15802
362948005411	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
362948005412	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
362948005413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948005414	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
362948005415	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
362948005416	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
362948005417	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
362948005418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
362948005419	Coenzyme A binding pocket [chemical binding]; other site
362948005420	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
362948005421	IHF dimer interface [polypeptide binding]; other site
362948005422	IHF - DNA interface [nucleotide binding]; other site
362948005423	Similar to endopeptidase lactocepin; nonfunctional due to frameshift
362948005424	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
362948005425	FAD binding pocket [chemical binding]; other site
362948005426	conserved FAD binding motif [chemical binding]; other site
362948005427	phosphate binding motif [ion binding]; other site
362948005428	beta-alpha-beta structure motif; other site
362948005429	NAD binding pocket [chemical binding]; other site
362948005430	Transposase IS200 like; Region: Y1_Tnp; cl00848
362948005431	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
362948005432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
362948005433	Probable transposase; Region: OrfB_IS605; pfam01385
362948005434	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
362948005435	Ferritin-like domain; Region: Ferritin; pfam00210
362948005436	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
362948005437	dimerization interface [polypeptide binding]; other site
362948005438	DPS ferroxidase diiron center [ion binding]; other site
362948005439	ion pore; other site
362948005440	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
362948005441	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
362948005442	ligand binding site [chemical binding]; other site
362948005443	flexible hinge region; other site
362948005444	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
362948005445	putative switch regulator; other site
362948005446	non-specific DNA interactions [nucleotide binding]; other site
362948005447	DNA binding site [nucleotide binding]
362948005448	sequence specific DNA binding site [nucleotide binding]; other site
362948005449	putative cAMP binding site [chemical binding]; other site
362948005450	Similar to transposase ISLasa6b, IS3 family; nonfunctional due to truncation
362948005451	Similar to transposase ISLasa13, IS6 family; nonfunctional due to frameshift
362948005452	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
362948005453	metal-binding site [ion binding]
362948005454	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
362948005455	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
362948005456	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
362948005457	Helix-turn-helix domains; Region: HTH; cl00088
362948005458	putative transposase OrfB; Reviewed; Region: PHA02517
362948005459	HTH-like domain; Region: HTH_21; pfam13276
362948005460	Integrase core domain; Region: rve; cl01316
362948005461	Integrase core domain; Region: rve_3; cl15866
362948005462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362948005463	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362948005464	putative substrate translocation pore; other site
362948005465	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
362948005466	Major Facilitator Superfamily; Region: MFS_1; pfam07690
362948005467	putative substrate translocation pore; other site
362948005468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
362948005469	Helix-turn-helix domains; Region: HTH; cl00088
362948005470	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
362948005471	putative dimerization interface [polypeptide binding]; other site
362948005472	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
362948005473	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
362948005474	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
362948005475	classical (c) SDRs; Region: SDR_c; cd05233
362948005476	NAD(P) binding site [chemical binding]; other site
362948005477	active site
362948005478	FMN-binding domain; Region: FMN_bind; cl01081
362948005479	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
362948005480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948005481	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
362948005482	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
362948005483	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
362948005484	shikimate binding site; other site
362948005485	NAD(P) binding site [chemical binding]; other site
362948005486	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
362948005487	3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093
362948005488	active site
362948005489	catalytic residue [active]
362948005490	dimer interface [polypeptide binding]; other site
362948005491	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
362948005492	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
362948005493	active site
362948005494	DNA binding site [nucleotide binding]
362948005495	Int/Topo IB signature motif; other site
362948005496	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
362948005497	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
362948005498	active site
362948005499	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
362948005500	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
362948005501	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
362948005502	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
362948005503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362948005504	active site
362948005505	phosphorylation site [posttranslational modification]
362948005506	intermolecular recognition site; other site
362948005507	dimerization interface [polypeptide binding]; other site
362948005508	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
362948005509	DNA binding residues [nucleotide binding]
362948005510	dimerization interface [polypeptide binding]; other site
362948005511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
362948005512	Histidine kinase; Region: HisKA_3; pfam07730
362948005513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
362948005514	ATP binding site [chemical binding]; other site
362948005515	Mg2+ binding site [ion binding]; other site
362948005516	G-X-G motif; other site
362948005517	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
362948005518	ABC-2 type transporter; Region: ABC2_membrane; cl11417
362948005519	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
362948005520	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
362948005521	Walker A/P-loop; other site
362948005522	ATP binding site [chemical binding]; other site
362948005523	Q-loop/lid; other site
362948005524	ABC transporter signature motif; other site
362948005525	Walker B; other site
362948005526	D-loop; other site
362948005527	H-loop/switch region; other site
362948005528	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
362948005529	tetramer (dimer of dimers) interface [polypeptide binding]; other site
362948005530	active site
362948005531	dimer interface [polypeptide binding]; other site
362948005532	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
362948005533	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
362948005534	substrate binding site [chemical binding]; other site
362948005535	hexamer interface [polypeptide binding]; other site
362948005536	metal binding site [ion binding]; metal-binding site
362948005537	Similar to DNA integration/recombination/inversion protein; nonfunctional due to frameshift
362948005538	NlpC/P60 family; Region: NLPC_P60; cl11438
362948005539	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
362948005540	AAA-like domain; Region: AAA_10; pfam12846
362948005541	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
362948005542	Walker A motif; other site
362948005543	ATP binding site [chemical binding]; other site
362948005544	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
362948005545	Walker B motif; other site
362948005546	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
362948005547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362948005548	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
362948005549	Walker A motif; other site
362948005550	ATP binding site [chemical binding]; other site
362948005551	Walker B motif; other site
362948005552	arginine finger; other site
362948005553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
362948005554	Walker A motif; other site
362948005555	ATP binding site [chemical binding]; other site
362948005556	Walker B motif; other site
362948005557	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
362948005558	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
362948005559	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
362948005560	active site
362948005561	putative interdomain interaction site [polypeptide binding]; other site
362948005562	putative metal-binding site [ion binding]; other site
362948005563	putative nucleotide binding site [chemical binding]; other site
362948005564	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
362948005565	domain I; other site
362948005566	DNA binding groove [nucleotide binding]
362948005567	phosphate binding site [ion binding]; other site
362948005568	domain II; other site
362948005569	domain III; other site
362948005570	nucleotide binding site [chemical binding]; other site
362948005571	catalytic site [active]
362948005572	domain IV; other site
362948005573	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
362948005574	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
362948005575	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
362948005576	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
362948005577	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
362948005578	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
362948005579	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
362948005580	Similar to surface protein antigen precursor SapA; nonfunctional due to truncation
362948005581	Glucan-binding protein C; Region: GbpC; pfam08363
362948005582	Similar to conserved hypothetical protein; nonfunctional due to truncation
362948005583	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
362948005584	Int/Topo IB signature motif; other site
362948005585	Fic family protein [Function unknown]; Region: COG3177
362948005586	Fic/DOC family; Region: Fic; cl00960
362948005587	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362948005588	non-specific DNA binding site [nucleotide binding]; other site
362948005589	salt bridge; other site
362948005590	sequence-specific DNA binding site [nucleotide binding]; other site
362948005591	Domain of unknown function (DUF955); Region: DUF955; cl01076
362948005592	K+ potassium transporter; Region: K_trans; cl15781
362948005593	hypothetical protein; Provisional; Region: PRK11281
362948005594	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362948005595	non-specific DNA binding site [nucleotide binding]; other site
362948005596	salt bridge; other site
362948005597	sequence-specific DNA binding site [nucleotide binding]; other site
362948005598	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
362948005599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
362948005600	Similar to conserved hypothetical protein; nonfunctional due to frameshift
362948005601	Similar to hypothetical protein; nonfunctional due to frameshift
362948005602	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
362948005603	catalytic residues [active]
362948005604	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362948005605	catalytic residues [active]
362948005606	Similar to hypothetical protein; nonfunctional due to truncation
362948005607	Similar to replication protein; nonfunctional due to truncation
362948005608	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
362948005609	Arc-like DNA binding domain; Region: Arc; pfam03869
362948005610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
362948005611	non-specific DNA binding site [nucleotide binding]; other site
362948005612	salt bridge; other site
362948005613	sequence-specific DNA binding site [nucleotide binding]; other site
362948005614	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362948005615	non-specific DNA binding site [nucleotide binding]; other site
362948005616	salt bridge; other site
362948005617	sequence-specific DNA binding site [nucleotide binding]; other site
362948005618	Fic/DOC family; Region: Fic; cl00960
362948005619	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
362948005620	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
362948005621	active site
362948005622	nucleophile elbow; other site
362948005623	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
362948005624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
362948005625	FeS/SAM binding site; other site
362948005626	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
362948005627	Pyruvate formate lyase 1; Region: PFL1; cd01678
362948005628	coenzyme A binding site [chemical binding]; other site
362948005629	active site
362948005630	catalytic residues [active]
362948005631	glycine loop; other site
362948005632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
362948005633	Transposase; Region: DDE_Tnp_ISL3; pfam01610
362948005634	CCC1-related family of proteins; Region: CCC1_like; cl00278
362948005635	Similar to transposase ISLasa16, ISNCY family; nonfunctional due to interrupting stop codon
362948005636	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
362948005637	FeS assembly protein SufB; Region: sufB; TIGR01980
362948005638	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
362948005639	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
362948005640	trimerization site [polypeptide binding]; other site
362948005641	active site
362948005642	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
362948005643	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
362948005644	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
362948005645	catalytic residue [active]
362948005646	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
362948005647	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
362948005648	FeS assembly ATPase SufC; Region: sufC; TIGR01978
362948005649	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
362948005650	Walker A/P-loop; other site
362948005651	ATP binding site [chemical binding]; other site
362948005652	Q-loop/lid; other site
362948005653	ABC transporter signature motif; other site
362948005654	Walker B; other site
362948005655	D-loop; other site
362948005656	H-loop/switch region; other site
362948005657	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
362948005658	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
362948005659	peptide binding site [polypeptide binding]; other site
362948005660	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
362948005661	Cl- selectivity filter; other site
362948005662	Cl- binding residues [ion binding]; other site
362948005663	pore gating glutamate residue; other site
362948005664	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
362948005665	non-specific DNA binding site [nucleotide binding]; other site
362948005666	salt bridge; other site
362948005667	sequence-specific DNA binding site [nucleotide binding]; other site
362948005668	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
362948005669	D-lactate dehydrogenase; Validated; Region: PRK08605
362948005670	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948005671	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
362948005672	active site
362948005673	intersubunit interactions; other site
362948005674	catalytic residue [active]
362948005675	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
362948005676	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
362948005677	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
362948005678	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
362948005679	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
362948005680	Glucitol operon activator protein (GutM); Region: GutM; cl01890
362948005681	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
362948005682	Helix-turn-helix domains; Region: HTH; cl00088
362948005683	PRD domain; Region: PRD; cl15445
362948005684	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
362948005685	active site
362948005686	phosphorylation site [posttranslational modification]
362948005687	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
362948005688	classical (c) SDRs; Region: SDR_c; cd05233
362948005689	NAD(P) binding site [chemical binding]; other site
362948005690	active site
362948005691	Similar to phage protein; nonfunctional due to frameshift and truncation
362948005692	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
362948005693	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
362948005694	glucose-6-phosphate isomerase; Provisional; Region: PTZ00430
362948005695	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
362948005696	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
362948005697	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
362948005698	FMN binding site [chemical binding]; other site
362948005699	substrate binding site [chemical binding]; other site
362948005700	putative catalytic residue [active]
362948005701	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
362948005702	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
362948005703	putative catalytic cysteine [active]
362948005704	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
362948005705	putative active site [active]
362948005706	metal binding site [ion binding]; metal-binding site
362948005707	Similar to hypothetical surface protein; nonfunctional due to truncation
362948005708	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
362948005709	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
362948005710	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
362948005711	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
362948005712	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
362948005713	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
362948005714	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
362948005715	putative active site [active]
362948005716	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
362948005717	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
362948005718	Walker A/P-loop; other site
362948005719	ATP binding site [chemical binding]; other site
362948005720	Q-loop/lid; other site
362948005721	ABC transporter signature motif; other site
362948005722	Walker B; other site
362948005723	D-loop; other site
362948005724	H-loop/switch region; other site
362948005725	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
362948005726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
362948005727	active site
362948005728	phosphorylation site [posttranslational modification]
362948005729	intermolecular recognition site; other site
362948005730	dimerization interface [polypeptide binding]; other site
362948005731	LytTr DNA-binding domain; Region: LytTR; cl04498
362948005732	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
362948005733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
362948005734	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
362948005735	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
362948005736	catalytic residues [active]
362948005737	transaminase; Reviewed; Region: PRK08068
362948005738	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
362948005739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
362948005740	homodimer interface [polypeptide binding]; other site
362948005741	catalytic residue [active]
362948005742	Predicted amidohydrolase [General function prediction only]; Region: COG0388
362948005743	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
362948005744	putative active site [active]
362948005745	catalytic triad [active]
362948005746	putative dimer interface [polypeptide binding]; other site
362948005747	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
362948005748	Domain of unknown function DUF59; Region: DUF59; cl00941
362948005749	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
362948005750	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
362948005751	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
362948005752	Similar to sialidase; nonfunctional due to frameshift and truncation
362948005753	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
362948005754	MFS/sugar transport protein; Region: MFS_2; pfam13347
362948005755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948005756	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
362948005757	Domain of unknown function (DUF386); Region: DUF386; cl01047
362948005758	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
362948005759	active site
362948005760	multimer interface [polypeptide binding]; other site
362948005761	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
362948005762	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
362948005763	N-acetylneuraminate lyase; Region: nanA; TIGR00683
362948005764	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
362948005765	inhibitor site; inhibition site
362948005766	active site
362948005767	dimer interface [polypeptide binding]; other site
362948005768	catalytic residue [active]
362948005769	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
362948005770	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
362948005771	putative active site cavity [active]
362948005772	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
362948005773	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
362948005774	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
362948005775	putative active site [active]
362948005776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
362948005777	NAD(P) binding site [chemical binding]; other site
362948005778	active site
362948005779	inner membrane transporter YjeM; Provisional; Region: PRK15238
362948005780	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
362948005781	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
362948005782	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
362948005783	G1 box; other site
362948005784	putative GEF interaction site [polypeptide binding]; other site
362948005785	GTP/Mg2+ binding site [chemical binding]; other site
362948005786	Switch I region; other site
362948005787	G2 box; other site
362948005788	G3 box; other site
362948005789	Switch II region; other site
362948005790	G4 box; other site
362948005791	G5 box; other site
362948005792	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
362948005793	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
362948005794	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
362948005795	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
362948005796	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
362948005797	TPP-binding site [chemical binding]; other site
362948005798	dimer interface [polypeptide binding]; other site
362948005799	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
362948005800	PYR/PP interface [polypeptide binding]; other site
362948005801	dimer interface [polypeptide binding]; other site
362948005802	TPP binding site [chemical binding]; other site
362948005803	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
362948005804	active site
362948005805	intersubunit interactions; other site
362948005806	catalytic residue [active]
362948005807	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
362948005808	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
362948005809	substrate binding site [chemical binding]; other site
362948005810	hexamer interface [polypeptide binding]; other site
362948005811	metal binding site [ion binding]; metal-binding site
362948005812	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
362948005813	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
362948005814	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
362948005815	active site
362948005816	phosphorylation site [posttranslational modification]
362948005817	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
362948005818	active pocket/dimerization site; other site
362948005819	active site
362948005820	phosphorylation site [posttranslational modification]
362948005821	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
362948005822	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
362948005823	putative NAD(P) binding site [chemical binding]; other site
362948005824	putative catalytic Zn binding site [ion binding]; other site
362948005825	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
362948005826	Helix-turn-helix domains; Region: HTH; cl00088
362948005827	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
362948005828	putative phosphoketolase; Provisional; Region: PRK05261
362948005829	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
362948005830	TPP-binding site; other site
362948005831	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
362948005832	XFP C-terminal domain; Region: XFP_C; pfam09363
362948005833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
362948005834	HTH-like domain; Region: HTH_21; pfam13276
362948005835	Integrase core domain; Region: rve; cl01316
362948005836	Integrase core domain; Region: rve_3; cl15866
362948005837	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
362948005838	Helix-turn-helix domains; Region: HTH; cl00088