-- dump date 20120504_151400 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272623000001 REFSEQ gene predictions performed by GeneMark 2.4/GeneMark.hmm 2.0 with comparison to original submitter provided annotation. tRNA predictions performed by tRNAscan-SE v.1.23. rRNA predictions performed by BLAST 272623000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272623000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000004 Walker A motif; other site 272623000005 ATP binding site [chemical binding]; other site 272623000006 Walker B motif; other site 272623000007 arginine finger; other site 272623000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272623000009 DnaA box-binding interface [nucleotide binding]; other site 272623000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272623000011 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 272623000012 putative DNA binding surface [nucleotide binding]; other site 272623000013 dimer interface [polypeptide binding]; other site 272623000014 beta-clamp/clamp loader binding surface; other site 272623000015 beta-clamp/translesion DNA polymerase binding surface; other site 272623000016 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 272623000017 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272623000018 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272623000019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000021 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 272623000022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000023 non-specific DNA binding site [nucleotide binding]; other site 272623000024 salt bridge; other site 272623000025 sequence-specific DNA binding site [nucleotide binding]; other site 272623000026 GTP-binding protein YchF; Reviewed; Region: PRK09601 272623000027 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 272623000028 G1 box; other site 272623000029 GTP/Mg2+ binding site [chemical binding]; other site 272623000030 Switch I region; other site 272623000031 G2 box; other site 272623000032 Switch II region; other site 272623000033 G3 box; other site 272623000034 G4 box; other site 272623000035 G5 box; other site 272623000036 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272623000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000038 non-specific DNA binding site [nucleotide binding]; other site 272623000039 salt bridge; other site 272623000040 sequence-specific DNA binding site [nucleotide binding]; other site 272623000041 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 272623000042 FtsX-like permease family; Region: FtsX; cl15850 272623000043 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272623000044 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623000045 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272623000046 Walker A/P-loop; other site 272623000047 ATP binding site [chemical binding]; other site 272623000048 Q-loop/lid; other site 272623000049 ABC transporter signature motif; other site 272623000050 Walker B; other site 272623000051 D-loop; other site 272623000052 H-loop/switch region; other site 272623000053 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272623000054 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000055 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272623000056 putative active site [active] 272623000057 catalytic residue [active] 272623000058 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272623000059 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 272623000060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623000061 ATP binding site [chemical binding]; other site 272623000062 putative Mg++ binding site [ion binding]; other site 272623000063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623000064 nucleotide binding region [chemical binding]; other site 272623000065 ATP-binding site [chemical binding]; other site 272623000066 TRCF domain; Region: TRCF; cl04088 272623000067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623000068 RNA binding surface [nucleotide binding]; other site 272623000069 Septum formation initiator; Region: DivIC; cl11433 272623000070 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623000071 RNA binding site [nucleotide binding]; other site 272623000072 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272623000073 SH3-like domain; Region: SH3_8; pfam13457 272623000074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623000075 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272623000076 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272623000077 Ligand Binding Site [chemical binding]; other site 272623000078 B3/4 domain; Region: B3_4; cl11458 272623000079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623000080 active site 272623000081 FtsH Extracellular; Region: FtsH_ext; pfam06480 272623000082 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272623000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000084 Walker A motif; other site 272623000085 ATP binding site [chemical binding]; other site 272623000086 Walker B motif; other site 272623000087 arginine finger; other site 272623000088 Peptidase family M41; Region: Peptidase_M41; pfam01434 272623000089 similar to mannitol-specific enzyme II 272623000090 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272623000091 Helix-turn-helix domains; Region: HTH; cl00088 272623000092 PRD domain; Region: PRD; cl15445 272623000093 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272623000094 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272623000095 active site 272623000096 phosphorylation site [posttranslational modification] 272623000097 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272623000098 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272623000099 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272623000100 Bacteriophage bIL310 272623000101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623000102 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623000103 Terminase small subunit; Region: Terminase_2; cl01513 272623000104 Phage associated DNA primase [General function prediction only]; Region: COG3378 272623000105 D5 N terminal like; Region: D5_N; cl07360 272623000106 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 272623000107 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 272623000108 polymerase nucleotide-binding site; other site 272623000109 DNA-binding residues [nucleotide binding]; DNA binding site 272623000110 nucleotide binding site [chemical binding]; other site 272623000111 primase nucleotide-binding site [nucleotide binding]; other site 272623000112 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 272623000113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000114 non-specific DNA binding site [nucleotide binding]; other site 272623000115 salt bridge; other site 272623000116 sequence-specific DNA binding site [nucleotide binding]; other site 272623000117 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623000118 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272623000119 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 272623000120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000121 non-specific DNA binding site [nucleotide binding]; other site 272623000122 salt bridge; other site 272623000123 sequence-specific DNA binding site [nucleotide binding]; other site 272623000124 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623000125 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623000126 Int/Topo IB signature motif; other site 272623000127 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272623000128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000129 Coenzyme A binding pocket [chemical binding]; other site 272623000130 TM2 domain; Region: TM2; cl00984 272623000131 Sulfate transporter family; Region: Sulfate_transp; cl15842 272623000132 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272623000133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000134 Integrase core domain; Region: rve; cl01316 272623000135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623000136 HTH-like domain; Region: HTH_21; pfam13276 272623000137 Integrase core domain; Region: rve; cl01316 272623000138 Integrase core domain; Region: rve_3; cl15866 272623000139 Helix-turn-helix domains; Region: HTH; cl00088 272623000140 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272623000141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000142 Coenzyme A binding pocket [chemical binding]; other site 272623000143 aromatic amino acid aminotransferase; Validated; Region: PRK07309 272623000144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623000145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000146 homodimer interface [polypeptide binding]; other site 272623000147 catalytic residue [active] 272623000148 Recombination protein O N terminal; Region: RecO_N; pfam11967 272623000149 DNA repair protein RecO; Region: reco; TIGR00613 272623000150 Recombination protein O C terminal; Region: RecO_C; pfam02565 272623000151 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272623000152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623000154 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623000155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272623000156 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 272623000157 E3 interaction surface; other site 272623000158 lipoyl attachment site [posttranslational modification]; other site 272623000159 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272623000160 E3 interaction surface; other site 272623000161 lipoyl attachment site [posttranslational modification]; other site 272623000162 e3 binding domain; Region: E3_binding; pfam02817 272623000163 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 272623000164 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272623000165 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272623000166 TPP binding site [chemical binding]; other site 272623000167 alpha subunit interface [polypeptide binding]; other site 272623000168 heterodimer interface [polypeptide binding]; other site 272623000169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623000170 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272623000171 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272623000172 tetramer interface [polypeptide binding]; other site 272623000173 TPP-binding site [chemical binding]; other site 272623000174 heterodimer interface [polypeptide binding]; other site 272623000175 phosphorylation loop region [posttranslational modification] 272623000176 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272623000177 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272623000178 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272623000179 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272623000180 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 272623000181 active site 272623000182 catalytic site [active] 272623000183 metal binding site [ion binding]; metal-binding site 272623000184 dimer interface [polypeptide binding]; other site 272623000185 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272623000186 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623000187 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272623000188 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272623000189 active site 272623000190 HIGH motif; other site 272623000191 dimer interface [polypeptide binding]; other site 272623000192 KMSKS motif; other site 272623000193 OsmC-like protein; Region: OsmC; cl00767 272623000194 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623000195 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 272623000196 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623000197 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623000198 active site 272623000199 motif I; other site 272623000200 motif II; other site 272623000201 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623000202 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272623000203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000204 Walker A/P-loop; other site 272623000205 ATP binding site [chemical binding]; other site 272623000206 Q-loop/lid; other site 272623000207 ABC transporter signature motif; other site 272623000208 Walker B; other site 272623000209 D-loop; other site 272623000210 H-loop/switch region; other site 272623000211 ABC transporter; Region: ABC_tran_2; pfam12848 272623000212 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623000213 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 272623000214 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623000215 homodimer interface [polypeptide binding]; other site 272623000216 substrate-cofactor binding pocket; other site 272623000217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000218 catalytic residue [active] 272623000219 short chain dehydrogenase; Validated; Region: PRK06182 272623000220 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623000221 NADP binding site [chemical binding]; other site 272623000222 active site 272623000223 steroid binding site; other site 272623000224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623000225 Ligand Binding Site [chemical binding]; other site 272623000226 Predicted esterase [General function prediction only]; Region: COG0400 272623000227 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272623000228 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272623000229 Zn binding site [ion binding]; other site 272623000230 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272623000231 Zn binding site [ion binding]; other site 272623000232 Flavin Reductases; Region: FlaRed; cl00801 272623000233 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 272623000234 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 272623000235 putative active site [active] 272623000236 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000238 Walker A/P-loop; other site 272623000239 ATP binding site [chemical binding]; other site 272623000240 Q-loop/lid; other site 272623000241 ABC transporter signature motif; other site 272623000242 Walker B; other site 272623000243 D-loop; other site 272623000244 H-loop/switch region; other site 272623000245 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272623000246 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623000247 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272623000248 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623000249 putative transposase OrfB; Reviewed; Region: PHA02517 272623000250 Integrase core domain; Region: rve; cl01316 272623000251 Helix-turn-helix domains; Region: HTH; cl00088 272623000252 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623000253 Helix-turn-helix domains; Region: HTH; cl00088 272623000254 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 272623000255 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 272623000256 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 272623000257 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272623000258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623000259 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623000260 ParB-like partition proteins; Region: parB_part; TIGR00180 272623000261 ParB-like nuclease domain; Region: ParBc; cl02129 272623000262 KorB domain; Region: KorB; pfam08535 272623000263 recombination factor protein RarA; Reviewed; Region: PRK13342 272623000264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623000265 Walker A motif; other site 272623000266 ATP binding site [chemical binding]; other site 272623000267 Walker B motif; other site 272623000268 arginine finger; other site 272623000269 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272623000270 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272623000271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000272 Coenzyme A binding pocket [chemical binding]; other site 272623000273 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 272623000274 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623000275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000276 Walker A/P-loop; other site 272623000277 ATP binding site [chemical binding]; other site 272623000278 Q-loop/lid; other site 272623000279 ABC transporter signature motif; other site 272623000280 Walker B; other site 272623000281 D-loop; other site 272623000282 H-loop/switch region; other site 272623000283 ABC transporter; Region: ABC_tran_2; pfam12848 272623000284 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623000285 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272623000286 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272623000287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623000288 S-adenosylmethionine binding site [chemical binding]; other site 272623000289 RNA methyltransferase, RsmE family; Region: TIGR00046 272623000290 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 272623000291 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272623000292 putative active site [active] 272623000293 putative metal binding site [ion binding]; other site 272623000294 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272623000295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623000296 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623000297 synthetase active site [active] 272623000298 NTP binding site [chemical binding]; other site 272623000299 metal binding site [ion binding]; metal-binding site 272623000300 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272623000301 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272623000302 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272623000303 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272623000304 Ligand binding site; other site 272623000305 Putative Catalytic site; other site 272623000306 DXD motif; other site 272623000307 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272623000308 putative active site [active] 272623000309 dimerization interface [polypeptide binding]; other site 272623000310 putative tRNAtyr binding site [nucleotide binding]; other site 272623000311 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623000312 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272623000313 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623000314 amino acid transporter; Region: 2A0306; TIGR00909 272623000315 Spore germination protein; Region: Spore_permease; cl15802 272623000316 Spore germination protein; Region: Spore_permease; cl15802 272623000317 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272623000318 putative acyl-acceptor binding pocket; other site 272623000319 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272623000320 Helix-turn-helix domains; Region: HTH; cl00088 272623000321 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623000322 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272623000323 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 272623000324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623000325 nucleotide binding region [chemical binding]; other site 272623000326 ATP-binding site [chemical binding]; other site 272623000327 SEC-C motif; Region: SEC-C; pfam02810 272623000328 NeuB family; Region: NeuB; cl00496 272623000329 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272623000330 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272623000331 dimerization domain swap beta strand [polypeptide binding]; other site 272623000332 regulatory protein interface [polypeptide binding]; other site 272623000333 active site 272623000334 regulatory phosphorylation site [posttranslational modification]; other site 272623000335 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272623000336 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272623000337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 272623000338 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 272623000339 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 272623000340 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272623000341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623000342 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 272623000343 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272623000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000345 putative substrate translocation pore; other site 272623000346 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 272623000347 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272623000348 ANP binding site [chemical binding]; other site 272623000349 Substrate Binding Site II [chemical binding]; other site 272623000350 Substrate Binding Site I [chemical binding]; other site 272623000351 argininosuccinate lyase; Provisional; Region: PRK00855 272623000352 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272623000353 active sites [active] 272623000354 tetramer interface [polypeptide binding]; other site 272623000355 drug efflux system protein MdtG; Provisional; Region: PRK09874 272623000356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000357 putative substrate translocation pore; other site 272623000358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000359 Helix-turn-helix domains; Region: HTH; cl00088 272623000360 Ribonuclease P; Region: Ribonuclease_P; cl00457 272623000361 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272623000362 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272623000363 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272623000364 G-X-X-G motif; other site 272623000365 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272623000366 RxxxH motif; other site 272623000367 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 272623000368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000369 non-specific DNA binding site [nucleotide binding]; other site 272623000370 salt bridge; other site 272623000371 sequence-specific DNA binding site [nucleotide binding]; other site 272623000372 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623000373 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623000374 Helix-turn-helix domains; Region: HTH; cl00088 272623000375 putative transposase OrfB; Reviewed; Region: PHA02517 272623000376 Integrase core domain; Region: rve; cl01316 272623000377 Helix-turn-helix domains; Region: HTH; cl00088 272623000378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623000379 Helix-turn-helix domains; Region: HTH; cl00088 272623000380 putative transposase OrfB; Reviewed; Region: PHA02517 272623000381 Integrase core domain; Region: rve; cl01316 272623000382 putative transposase OrfB; Reviewed; Region: PHA02517 272623000383 Integrase core domain; Region: rve; cl01316 272623000384 Helix-turn-helix domains; Region: HTH; cl00088 272623000385 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 272623000386 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 272623000387 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 272623000388 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623000389 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272623000390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000391 NAD(P) binding site [chemical binding]; other site 272623000392 active site 272623000393 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 272623000394 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 272623000395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000396 NAD(P) binding site [chemical binding]; other site 272623000397 active site 272623000398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000399 Helix-turn-helix domains; Region: HTH; cl00088 272623000400 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272623000401 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000402 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000403 Collagen binding domain; Region: Collagen_bind; pfam05737 272623000404 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000405 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000406 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000407 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000408 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000409 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000410 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000411 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000412 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623000413 Gram positive anchor; Region: Gram_pos_anchor; cl15427 272623000414 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 272623000415 Protein of unknown function (DUF975); Region: DUF975; cl10504 272623000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623000418 putative substrate translocation pore; other site 272623000419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000420 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272623000421 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 272623000422 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 272623000423 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272623000424 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272623000425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623000426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623000427 homodimer interface [polypeptide binding]; other site 272623000428 catalytic residue [active] 272623000429 CodY GAF-like domain; Region: CodY; pfam06018 272623000430 GTP-sensing transcriptional pleiotropic repressor CodY; Region: codY_Gpos; TIGR02787 272623000431 Helix-turn-helix domains; Region: HTH; cl00088 272623000432 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 272623000433 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272623000434 Amidase; Region: Amidase; cl11426 272623000435 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 272623000436 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 272623000437 nudix motif; other site 272623000438 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272623000439 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272623000440 GatB domain; Region: GatB_Yqey; cl11497 272623000441 amidase; Provisional; Region: PRK06529 272623000442 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 272623000443 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272623000444 MatE; Region: MatE; cl10513 272623000445 MatE; Region: MatE; cl10513 272623000446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 272623000447 DNA-binding site [nucleotide binding]; DNA binding site 272623000448 RNA-binding motif; other site 272623000449 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 272623000450 Rhomboid family; Region: Rhomboid; cl11446 272623000451 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272623000452 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623000453 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 272623000454 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623000455 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272623000456 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623000457 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623000458 trimer interface [polypeptide binding]; other site 272623000459 active site 272623000460 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272623000461 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272623000462 active site 272623000463 metal binding site [ion binding]; metal-binding site 272623000464 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272623000465 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 272623000466 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 272623000467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623000468 FeS/SAM binding site; other site 272623000469 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272623000470 dimer interface [polypeptide binding]; other site 272623000471 FMN binding site [chemical binding]; other site 272623000472 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272623000473 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623000474 substrate binding pocket [chemical binding]; other site 272623000475 chain length determination region; other site 272623000476 substrate-Mg2+ binding site; other site 272623000477 catalytic residues [active] 272623000478 aspartate-rich region 1; other site 272623000479 active site lid residues [active] 272623000480 aspartate-rich region 2; other site 272623000481 UbiA prenyltransferase family; Region: UbiA; cl00337 272623000482 CAAX protease self-immunity; Region: Abi; cl00558 272623000483 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272623000484 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 272623000485 G1 box; other site 272623000486 GTP/Mg2+ binding site [chemical binding]; other site 272623000487 Switch I region; other site 272623000488 G2 box; other site 272623000489 G3 box; other site 272623000490 Switch II region; other site 272623000491 G4 box; other site 272623000492 G5 box; other site 272623000493 Nucleoside recognition; Region: Gate; cl00486 272623000494 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272623000495 Nucleoside recognition; Region: Gate; cl00486 272623000496 FeoA domain; Region: FeoA; cl00838 272623000497 FeoA domain; Region: FeoA; cl00838 272623000498 SelR domain; Region: SelR; cl00369 272623000499 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272623000500 DAK2 domain; Region: Dak2; cl03685 272623000501 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 272623000502 Protein of unknown function (DUF322); Region: DUF322; cl00574 272623000503 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 272623000504 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 272623000505 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272623000506 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272623000507 substrate binding site; other site 272623000508 tetramer interface; other site 272623000509 Cupin domain; Region: Cupin_2; cl09118 272623000510 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272623000511 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272623000512 NAD binding site [chemical binding]; other site 272623000513 substrate binding site [chemical binding]; other site 272623000514 homodimer interface [polypeptide binding]; other site 272623000515 active site 272623000516 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272623000517 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272623000518 NADP binding site [chemical binding]; other site 272623000519 active site 272623000520 putative substrate binding site [chemical binding]; other site 272623000521 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 272623000522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623000523 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 272623000524 Probable Catalytic site; other site 272623000525 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623000526 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272623000527 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 272623000528 Walker A/P-loop; other site 272623000529 ATP binding site [chemical binding]; other site 272623000530 Q-loop/lid; other site 272623000531 ABC transporter signature motif; other site 272623000532 Walker B; other site 272623000533 D-loop; other site 272623000534 H-loop/switch region; other site 272623000535 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 272623000536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000537 active site 272623000538 Domain of unknown function (DUF947); Region: DUF947; pfam06102 272623000539 Rhamnan synthesis protein F; Region: RgpF; cl01529 272623000540 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 272623000541 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272623000542 Ligand binding site; other site 272623000543 Putative Catalytic site; other site 272623000544 DXD motif; other site 272623000545 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 272623000546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000547 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272623000548 NAD(P) binding site [chemical binding]; other site 272623000549 active site 272623000550 colanic acid exporter; Provisional; Region: PRK10459 272623000551 MatE; Region: MatE; cl10513 272623000552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623000553 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272623000554 LicD family; Region: LicD; cl01378 272623000555 putative glycosyl transferase; Provisional; Region: PRK10073 272623000556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000557 active site 272623000558 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623000559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623000560 active site 272623000561 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272623000562 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 272623000563 active site 272623000564 catalytic site [active] 272623000565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623000566 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 272623000567 active site 272623000568 nucleotide binding site [chemical binding]; other site 272623000569 HIGH motif; other site 272623000570 KMSKS motif; other site 272623000571 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272623000572 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 272623000573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 272623000574 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 272623000575 active site 272623000576 GTPase YqeH; Provisional; Region: PRK13796 272623000577 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 272623000578 GTP/Mg2+ binding site [chemical binding]; other site 272623000579 G4 box; other site 272623000580 G5 box; other site 272623000581 G1 box; other site 272623000582 Switch I region; other site 272623000583 G2 box; other site 272623000584 G3 box; other site 272623000585 Switch II region; other site 272623000586 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272623000587 nudix motif; other site 272623000588 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272623000589 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272623000590 HflX GTPase family; Region: HflX; cd01878 272623000591 G1 box; other site 272623000592 GTP/Mg2+ binding site [chemical binding]; other site 272623000593 Switch I region; other site 272623000594 G2 box; other site 272623000595 G3 box; other site 272623000596 Switch II region; other site 272623000597 G4 box; other site 272623000598 G5 box; other site 272623000599 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 272623000600 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 272623000601 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272623000602 active site 272623000603 (T/H)XGH motif; other site 272623000604 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 272623000605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623000606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000607 Coenzyme A binding pocket [chemical binding]; other site 272623000608 Oligomerisation domain; Region: Oligomerisation; cl00519 272623000609 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272623000610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623000611 S-adenosylmethionine binding site [chemical binding]; other site 272623000612 hypothetical protein; Provisional; Region: PRK13670 272623000613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623000614 Domain of unknown function DUF28; Region: DUF28; cl00361 272623000615 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272623000616 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272623000617 ligand binding site [chemical binding]; other site 272623000618 active site 272623000619 UGI interface [polypeptide binding]; other site 272623000620 catalytic site [active] 272623000621 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 272623000622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000623 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 272623000624 Helix-turn-helix domains; Region: HTH; cl00088 272623000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000626 putative substrate translocation pore; other site 272623000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000628 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623000629 DNA binding residues [nucleotide binding] 272623000630 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 272623000631 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623000632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623000633 active site 272623000634 motif I; other site 272623000635 motif II; other site 272623000636 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623000637 Phosphoglycerate kinase; Region: PGK; pfam00162 272623000638 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272623000639 substrate binding site [chemical binding]; other site 272623000640 hinge regions; other site 272623000641 ADP binding site [chemical binding]; other site 272623000642 catalytic site [active] 272623000643 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 272623000644 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272623000645 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272623000646 Helix-turn-helix domains; Region: HTH; cl00088 272623000647 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 272623000648 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272623000649 DAK2 domain; Region: Dak2; cl03685 272623000650 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 272623000651 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 272623000652 amphipathic channel; other site 272623000653 Asn-Pro-Ala signature motifs; other site 272623000654 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 272623000655 Peptidase family C69; Region: Peptidase_C69; pfam03577 272623000656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623000657 Helix-turn-helix domains; Region: HTH; cl00088 272623000658 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272623000659 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 272623000660 Walker A/P-loop; other site 272623000661 ATP binding site [chemical binding]; other site 272623000662 Q-loop/lid; other site 272623000663 ABC transporter signature motif; other site 272623000664 Walker B; other site 272623000665 D-loop; other site 272623000666 H-loop/switch region; other site 272623000667 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623000668 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272623000669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623000670 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 272623000671 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272623000672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000673 flavoprotein, HI0933 family; Region: TIGR00275 272623000674 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272623000675 putative substrate binding site [chemical binding]; other site 272623000676 putative ATP binding site [chemical binding]; other site 272623000677 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 272623000678 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000679 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000681 Walker A/P-loop; other site 272623000682 ATP binding site [chemical binding]; other site 272623000683 Q-loop/lid; other site 272623000684 ABC transporter signature motif; other site 272623000685 Walker B; other site 272623000686 D-loop; other site 272623000687 H-loop/switch region; other site 272623000688 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000689 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000690 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 272623000691 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272623000692 Walker A/P-loop; other site 272623000693 ATP binding site [chemical binding]; other site 272623000694 Q-loop/lid; other site 272623000695 ABC transporter signature motif; other site 272623000696 Walker B; other site 272623000697 D-loop; other site 272623000698 H-loop/switch region; other site 272623000699 Domain of unknown function (DUF697); Region: DUF697; cl12064 272623000700 putative oxidoreductase; Provisional; Region: PRK10206 272623000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623000702 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 272623000703 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 272623000704 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272623000705 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623000706 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272623000707 active site 272623000708 catalytic tetrad [active] 272623000709 Isochorismatase family; Region: Isochorismatase; pfam00857 272623000710 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623000711 catalytic triad [active] 272623000712 conserved cis-peptide bond; other site 272623000713 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 272623000714 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623000715 putative peptidoglycan binding site; other site 272623000716 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623000717 putative peptidoglycan binding site; other site 272623000718 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623000719 putative peptidoglycan binding site; other site 272623000720 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272623000721 ATP cone domain; Region: ATP-cone; pfam03477 272623000722 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272623000723 effector binding site; other site 272623000724 active site 272623000725 Zn binding site [ion binding]; other site 272623000726 glycine loop; other site 272623000727 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 272623000728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623000729 FeS/SAM binding site; other site 272623000730 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 272623000731 enolase; Provisional; Region: eno; PRK00077 272623000732 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272623000733 dimer interface [polypeptide binding]; other site 272623000734 metal binding site [ion binding]; metal-binding site 272623000735 substrate binding pocket [chemical binding]; other site 272623000736 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13642 272623000737 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000738 Walker A/P-loop; other site 272623000739 ATP binding site [chemical binding]; other site 272623000740 Q-loop/lid; other site 272623000741 ABC transporter signature motif; other site 272623000742 Walker B; other site 272623000743 D-loop; other site 272623000744 H-loop/switch region; other site 272623000745 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 272623000746 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13643 272623000747 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000748 Walker A/P-loop; other site 272623000749 ATP binding site [chemical binding]; other site 272623000750 Q-loop/lid; other site 272623000751 ABC transporter signature motif; other site 272623000752 Walker B; other site 272623000753 D-loop; other site 272623000754 H-loop/switch region; other site 272623000755 Cobalt transport protein; Region: CbiQ; cl00463 272623000756 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272623000757 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272623000758 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272623000759 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 272623000760 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272623000761 putative trimer interface [polypeptide binding]; other site 272623000762 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272623000763 putative CoA binding site [chemical binding]; other site 272623000764 putative trimer interface [polypeptide binding]; other site 272623000765 putative CoA binding site [chemical binding]; other site 272623000766 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272623000767 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272623000768 metal binding site [ion binding]; metal-binding site 272623000769 putative dimer interface [polypeptide binding]; other site 272623000770 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272623000771 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272623000772 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272623000773 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272623000774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623000775 RNA binding surface [nucleotide binding]; other site 272623000776 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272623000777 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272623000778 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 272623000779 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272623000780 RNA binding site [nucleotide binding]; other site 272623000781 SprT homologues; Region: SprT; cl01182 272623000782 hypothetical protein; Provisional; Region: PRK04351 272623000783 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 272623000784 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272623000785 active site 272623000786 purine riboside binding site [chemical binding]; other site 272623000787 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272623000788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623000789 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272623000790 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 272623000791 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 272623000792 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272623000793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000794 Coenzyme A binding pocket [chemical binding]; other site 272623000795 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272623000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623000797 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623000798 Coenzyme A binding pocket [chemical binding]; other site 272623000799 UGMP family protein; Validated; Region: PRK09604 272623000800 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 272623000801 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 272623000802 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272623000803 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272623000804 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 272623000805 Walker A/P-loop; other site 272623000806 ATP binding site [chemical binding]; other site 272623000807 Q-loop/lid; other site 272623000808 ABC transporter signature motif; other site 272623000809 Walker B; other site 272623000810 D-loop; other site 272623000811 H-loop/switch region; other site 272623000812 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272623000813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000814 dimer interface [polypeptide binding]; other site 272623000815 conserved gate region; other site 272623000816 putative PBP binding loops; other site 272623000817 ABC-ATPase subunit interface; other site 272623000818 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272623000819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000820 dimer interface [polypeptide binding]; other site 272623000821 conserved gate region; other site 272623000822 ABC-ATPase subunit interface; other site 272623000823 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272623000824 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272623000825 active site 272623000826 metal binding site [ion binding]; metal-binding site 272623000827 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272623000828 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272623000829 dimer interface [polypeptide binding]; other site 272623000830 catalytic triad [active] 272623000831 peroxidatic and resolving cysteines [active] 272623000832 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 272623000833 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 272623000834 Zn binding site [ion binding]; other site 272623000835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000836 putative substrate translocation pore; other site 272623000837 H+ Antiporter protein; Region: 2A0121; TIGR00900 272623000838 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623000839 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272623000840 Cation efflux family; Region: Cation_efflux; cl00316 272623000841 Helix-turn-helix domains; Region: HTH; cl00088 272623000842 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000843 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623000845 Walker A/P-loop; other site 272623000846 ATP binding site [chemical binding]; other site 272623000847 Q-loop/lid; other site 272623000848 ABC transporter signature motif; other site 272623000849 Walker B; other site 272623000850 D-loop; other site 272623000851 H-loop/switch region; other site 272623000852 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623000853 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623000854 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 272623000855 Walker A/P-loop; other site 272623000856 ATP binding site [chemical binding]; other site 272623000857 Q-loop/lid; other site 272623000858 ABC transporter signature motif; other site 272623000859 Walker B; other site 272623000860 D-loop; other site 272623000861 H-loop/switch region; other site 272623000862 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272623000863 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272623000864 hinge; other site 272623000865 active site 272623000866 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 272623000867 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 272623000868 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 272623000869 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272623000870 putative deacylase active site [active] 272623000871 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 272623000872 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 272623000873 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 272623000874 NMT1-like family; Region: NMT1_2; cl15260 272623000875 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 272623000876 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 272623000877 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272623000878 Walker A/P-loop; other site 272623000879 ATP binding site [chemical binding]; other site 272623000880 Q-loop/lid; other site 272623000881 ABC transporter signature motif; other site 272623000882 Walker B; other site 272623000883 D-loop; other site 272623000884 H-loop/switch region; other site 272623000885 NIL domain; Region: NIL; cl09633 272623000886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272623000887 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 272623000888 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272623000889 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000890 Walker A/P-loop; other site 272623000891 ATP binding site [chemical binding]; other site 272623000892 Q-loop/lid; other site 272623000893 ABC transporter signature motif; other site 272623000894 Walker B; other site 272623000895 D-loop; other site 272623000896 H-loop/switch region; other site 272623000897 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 272623000898 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 272623000899 Walker A/P-loop; other site 272623000900 ATP binding site [chemical binding]; other site 272623000901 Q-loop/lid; other site 272623000902 ABC transporter signature motif; other site 272623000903 Walker B; other site 272623000904 D-loop; other site 272623000905 H-loop/switch region; other site 272623000906 Cobalt transport protein; Region: CbiQ; cl00463 272623000907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623000908 non-specific DNA binding site [nucleotide binding]; other site 272623000909 salt bridge; other site 272623000910 sequence-specific DNA binding site [nucleotide binding]; other site 272623000911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623000912 ABC-ATPase subunit interface; other site 272623000913 dimer interface [polypeptide binding]; other site 272623000914 putative PBP binding regions; other site 272623000915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623000916 ABC-ATPase subunit interface; other site 272623000917 dimer interface [polypeptide binding]; other site 272623000918 putative PBP binding regions; other site 272623000919 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272623000920 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272623000921 intersubunit interface [polypeptide binding]; other site 272623000922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623000923 Helix-turn-helix domains; Region: HTH; cl00088 272623000924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623000925 dimerization interface [polypeptide binding]; other site 272623000926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272623000927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623000928 putative substrate translocation pore; other site 272623000929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623000930 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 272623000931 active site 272623000932 catalytic tetrad [active] 272623000933 Helix-turn-helix domains; Region: HTH; cl00088 272623000934 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272623000935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272623000936 putative metal binding site [ion binding]; other site 272623000937 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623000938 catalytic core [active] 272623000939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623000940 peroxiredoxin; Region: AhpC; TIGR03137 272623000941 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272623000942 dimer interface [polypeptide binding]; other site 272623000943 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272623000944 catalytic triad [active] 272623000945 peroxidatic and resolving cysteines [active] 272623000946 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 272623000947 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 272623000948 catalytic residue [active] 272623000949 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 272623000950 catalytic residues [active] 272623000951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623000952 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272623000953 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272623000954 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623000955 recombination protein RecR; Reviewed; Region: recR; PRK00076 272623000956 RecR protein; Region: RecR; pfam02132 272623000957 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272623000958 putative active site [active] 272623000959 putative metal-binding site [ion binding]; other site 272623000960 tetramer interface [polypeptide binding]; other site 272623000961 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272623000962 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272623000963 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623000964 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272623000965 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623000966 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623000967 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623000968 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623000969 peptide binding site [polypeptide binding]; other site 272623000970 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623000971 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623000972 peptide binding site [polypeptide binding]; other site 272623000973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272623000974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000975 dimer interface [polypeptide binding]; other site 272623000976 conserved gate region; other site 272623000977 putative PBP binding loops; other site 272623000978 ABC-ATPase subunit interface; other site 272623000979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272623000980 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272623000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623000982 dimer interface [polypeptide binding]; other site 272623000983 conserved gate region; other site 272623000984 putative PBP binding loops; other site 272623000985 ABC-ATPase subunit interface; other site 272623000986 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272623000987 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272623000988 Walker A/P-loop; other site 272623000989 ATP binding site [chemical binding]; other site 272623000990 Q-loop/lid; other site 272623000991 ABC transporter signature motif; other site 272623000992 Walker B; other site 272623000993 D-loop; other site 272623000994 H-loop/switch region; other site 272623000995 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272623000996 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272623000997 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272623000998 Walker A/P-loop; other site 272623000999 ATP binding site [chemical binding]; other site 272623001000 Q-loop/lid; other site 272623001001 ABC transporter signature motif; other site 272623001002 Walker B; other site 272623001003 D-loop; other site 272623001004 H-loop/switch region; other site 272623001005 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272623001006 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 272623001007 G1 box; other site 272623001008 putative GEF interaction site [polypeptide binding]; other site 272623001009 GTP/Mg2+ binding site [chemical binding]; other site 272623001010 Switch I region; other site 272623001011 G2 box; other site 272623001012 G3 box; other site 272623001013 Switch II region; other site 272623001014 G4 box; other site 272623001015 G5 box; other site 272623001016 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272623001017 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272623001018 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272623001019 ATP binding site [chemical binding]; other site 272623001020 Mg++ binding site [ion binding]; other site 272623001021 motif III; other site 272623001022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001023 nucleotide binding region [chemical binding]; other site 272623001024 ATP-binding site [chemical binding]; other site 272623001025 GTPase Era; Reviewed; Region: era; PRK00089 272623001026 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272623001027 G1 box; other site 272623001028 GTP/Mg2+ binding site [chemical binding]; other site 272623001029 Switch I region; other site 272623001030 G2 box; other site 272623001031 Switch II region; other site 272623001032 G3 box; other site 272623001033 G4 box; other site 272623001034 G5 box; other site 272623001035 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 272623001036 asparagine synthetase B; Provisional; Region: asnB; PRK09431 272623001037 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272623001038 dimer interface [polypeptide binding]; other site 272623001039 active site 272623001040 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272623001041 Ligand Binding Site [chemical binding]; other site 272623001042 Molecular Tunnel; other site 272623001043 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272623001044 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272623001045 DNA binding site [nucleotide binding] 272623001046 catalytic residue [active] 272623001047 H2TH interface [polypeptide binding]; other site 272623001048 putative catalytic residues [active] 272623001049 turnover-facilitating residue; other site 272623001050 intercalation triad [nucleotide binding]; other site 272623001051 8OG recognition residue [nucleotide binding]; other site 272623001052 putative reading head residues; other site 272623001053 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272623001054 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272623001055 recombinase A; Provisional; Region: recA; PRK09354 272623001056 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272623001057 hexamer interface [polypeptide binding]; other site 272623001058 Walker A motif; other site 272623001059 ATP binding site [chemical binding]; other site 272623001060 Walker B motif; other site 272623001061 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623001062 Amino acid permease; Region: AA_permease; cl00524 272623001063 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623001064 Protein of unknown function (DUF964); Region: DUF964; cl01483 272623001065 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 272623001066 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272623001067 putative active site [active] 272623001068 putative metal binding residues [ion binding]; other site 272623001069 signature motif; other site 272623001070 putative triphosphate binding site [ion binding]; other site 272623001071 Protein of unknown function (DUF817); Region: DUF817; cl01520 272623001072 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623001073 synthetase active site [active] 272623001074 NTP binding site [chemical binding]; other site 272623001075 metal binding site [ion binding]; metal-binding site 272623001076 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 272623001077 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272623001078 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 272623001079 active site 272623001080 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 272623001081 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272623001082 active site 272623001083 Amino acid permease; Region: AA_permease; cl00524 272623001084 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623001085 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623001086 ApbE family; Region: ApbE; cl00643 272623001087 Helix-turn-helix domains; Region: HTH; cl00088 272623001088 putative transposase OrfB; Reviewed; Region: PHA02517 272623001089 Integrase core domain; Region: rve; cl01316 272623001090 Helix-turn-helix domains; Region: HTH; cl00088 272623001091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001092 Helix-turn-helix domains; Region: HTH; cl00088 272623001093 putative transposase OrfB; Reviewed; Region: PHA02517 272623001094 Integrase core domain; Region: rve; cl01316 272623001095 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272623001096 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272623001097 dimer interface [polypeptide binding]; other site 272623001098 putative anticodon binding site; other site 272623001099 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272623001100 motif 1; other site 272623001101 active site 272623001102 motif 2; other site 272623001103 motif 3; other site 272623001104 Helix-turn-helix domains; Region: HTH; cl00088 272623001105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623001106 dimerization interface [polypeptide binding]; other site 272623001107 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 272623001108 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623001109 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623001110 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623001111 NAD binding site [chemical binding]; other site 272623001112 dimer interface [polypeptide binding]; other site 272623001113 substrate binding site [chemical binding]; other site 272623001114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623001115 Helix-turn-helix domains; Region: HTH; cl00088 272623001116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623001117 dimerization interface [polypeptide binding]; other site 272623001118 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 272623001119 gating phenylalanine in ion channel; other site 272623001120 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272623001121 THUMP domain; Region: THUMP; cl12076 272623001122 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272623001123 Ligand Binding Site [chemical binding]; other site 272623001124 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623001125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001126 putative substrate translocation pore; other site 272623001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001128 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623001129 OsmC-like protein; Region: OsmC; cl00767 272623001130 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272623001131 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272623001132 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272623001133 active site 272623001134 HIGH motif; other site 272623001135 dimer interface [polypeptide binding]; other site 272623001136 KMSKS motif; other site 272623001137 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623001138 RNA binding surface [nucleotide binding]; other site 272623001139 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272623001140 Transglycosylase; Region: Transgly; cl07896 272623001141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623001142 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272623001143 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272623001144 oligomer interface [polypeptide binding]; other site 272623001145 active site 272623001146 metal binding site [ion binding]; metal-binding site 272623001147 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272623001148 catalytic residues [active] 272623001149 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272623001150 putative tRNA-binding site [nucleotide binding]; other site 272623001151 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272623001152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001153 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623001154 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623001155 dimer interface [polypeptide binding]; other site 272623001156 ssDNA binding site [nucleotide binding]; other site 272623001157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623001158 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272623001159 mobile loop; other site 272623001160 oligomerisation interface [polypeptide binding]; other site 272623001161 roof hairpin; other site 272623001162 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272623001163 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272623001164 ring oligomerisation interface [polypeptide binding]; other site 272623001165 ATP/Mg binding site [chemical binding]; other site 272623001166 stacking interactions; other site 272623001167 hinge regions; other site 272623001168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623001169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272623001170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272623001171 putative active site [active] 272623001172 heme pocket [chemical binding]; other site 272623001173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623001174 dimer interface [polypeptide binding]; other site 272623001175 phosphorylation site [posttranslational modification] 272623001176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623001177 ATP binding site [chemical binding]; other site 272623001178 Mg2+ binding site [ion binding]; other site 272623001179 G-X-G motif; other site 272623001180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623001181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623001182 active site 272623001183 phosphorylation site [posttranslational modification] 272623001184 intermolecular recognition site; other site 272623001185 dimerization interface [polypeptide binding]; other site 272623001186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623001187 DNA binding site [nucleotide binding] 272623001188 thymidylate kinase; Validated; Region: tmk; PRK00698 272623001189 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272623001190 TMP-binding site; other site 272623001191 ATP-binding site [chemical binding]; other site 272623001192 DNA polymerase III subunit delta'; Validated; Region: PRK07276 272623001193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001194 PSP1 C-terminal conserved region; Region: PSP1; cl00770 272623001195 TSC-22/dip/bun family; Region: TSC22; cl01853 272623001196 Predicted methyltransferases [General function prediction only]; Region: COG0313 272623001197 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 272623001198 mevalonate kinase; Region: mevalon_kin; TIGR00549 272623001199 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 272623001200 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623001201 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272623001202 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 272623001203 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 272623001204 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623001205 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272623001206 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272623001207 homotetramer interface [polypeptide binding]; other site 272623001208 FMN binding site [chemical binding]; other site 272623001209 homodimer contacts [polypeptide binding]; other site 272623001210 putative active site [active] 272623001211 putative substrate binding site [chemical binding]; other site 272623001212 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272623001213 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272623001214 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272623001215 Carbon starvation protein CstA; Region: CstA; cl00856 272623001216 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272623001217 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272623001218 ATP binding site [chemical binding]; other site 272623001219 Mg++ binding site [ion binding]; other site 272623001220 motif III; other site 272623001221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001222 nucleotide binding region [chemical binding]; other site 272623001223 ATP-binding site [chemical binding]; other site 272623001224 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623001225 putative active site [active] 272623001226 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623001227 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001228 putative active site [active] 272623001229 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272623001230 active site 272623001231 P-loop; other site 272623001232 phosphorylation site [posttranslational modification] 272623001233 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272623001234 active site 272623001235 methionine cluster; other site 272623001236 phosphorylation site [posttranslational modification] 272623001237 metal binding site [ion binding]; metal-binding site 272623001238 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623001239 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001240 putative active site [active] 272623001241 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623001242 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623001243 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623001244 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272623001245 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272623001246 nucleotide binding pocket [chemical binding]; other site 272623001247 K-X-D-G motif; other site 272623001248 catalytic site [active] 272623001249 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272623001250 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272623001251 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272623001252 Dimer interface [polypeptide binding]; other site 272623001253 BRCT sequence motif; other site 272623001254 putative lipid kinase; Reviewed; Region: PRK13055 272623001255 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 272623001256 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272623001257 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 272623001258 Walker A/P-loop; other site 272623001259 ATP binding site [chemical binding]; other site 272623001260 Q-loop/lid; other site 272623001261 ABC transporter signature motif; other site 272623001262 Walker B; other site 272623001263 D-loop; other site 272623001264 H-loop/switch region; other site 272623001265 TOBE domain; Region: TOBE_2; cl01440 272623001266 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272623001267 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272623001268 dimer interface [polypeptide binding]; other site 272623001269 PYR/PP interface [polypeptide binding]; other site 272623001270 TPP binding site [chemical binding]; other site 272623001271 substrate binding site [chemical binding]; other site 272623001272 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 272623001273 Domain of unknown function; Region: EKR; cl11037 272623001274 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272623001275 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272623001276 TPP-binding site [chemical binding]; other site 272623001277 dimer interface [polypeptide binding]; other site 272623001278 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272623001279 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272623001280 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272623001281 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272623001282 active site 272623001283 substrate binding site [chemical binding]; other site 272623001284 metal binding site [ion binding]; metal-binding site 272623001285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623001286 DNA-binding site [nucleotide binding]; DNA binding site 272623001287 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272623001288 UTRA domain; Region: UTRA; cl01230 272623001289 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272623001290 HPr interaction site; other site 272623001291 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623001292 active site 272623001293 phosphorylation site [posttranslational modification] 272623001294 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272623001295 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623001296 active site turn [active] 272623001297 phosphorylation site [posttranslational modification] 272623001298 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623001299 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272623001300 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272623001301 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272623001302 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272623001303 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272623001304 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001306 motif II; other site 272623001307 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623001308 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 272623001309 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623001310 nucleophilic elbow; other site 272623001311 catalytic triad; other site 272623001312 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 272623001313 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623001314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001315 Coenzyme A binding pocket [chemical binding]; other site 272623001316 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623001317 Bacteriophage bIL309 272623001318 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623001319 Phage integrase family; Region: Phage_integrase; pfam00589 272623001320 Int/Topo IB signature motif; other site 272623001321 Short C-terminal domain; Region: SHOCT; cl01373 272623001322 transcriptional repressor DicA; Reviewed; Region: PRK09706 272623001323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001324 non-specific DNA binding site [nucleotide binding]; other site 272623001325 salt bridge; other site 272623001326 sequence-specific DNA binding site [nucleotide binding]; other site 272623001327 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272623001328 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272623001329 Catalytic site [active] 272623001330 Lactococcus bacteriophage putative transcription regulator; Region: Phage_Treg; cl11500 272623001331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623001332 BRO family, N-terminal domain; Region: Bro-N; cl10591 272623001333 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 272623001334 Domain of unknown function (DUF771); Region: DUF771; cl09962 272623001335 Lactococcus bacteriophage putative transcription regulator; Region: Phage_Treg; cl11500 272623001336 RecT family; Region: RecT; cl04285 272623001337 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272623001338 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 272623001339 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 272623001340 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272623001341 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001342 Endodeoxyribonuclease RusA; Region: RusA; cl01885 272623001343 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623001344 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272623001345 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623001346 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623001347 trimer interface [polypeptide binding]; other site 272623001348 active site 272623001349 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623001350 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623001351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623001352 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623001353 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623001354 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272623001355 Phage terminase, small subunit; Region: Terminase_4; cl01525 272623001356 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623001357 Phage Terminase; Region: Terminase_1; pfam03354 272623001358 Phage-related protein [Function unknown]; Region: COG4695; cl01923 272623001359 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 272623001360 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 272623001361 Phage capsid family; Region: Phage_capsid; pfam05065 272623001362 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 272623001363 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 272623001364 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 272623001365 Protein of unknown function (DUF806); Region: DUF806; pfam05657 272623001366 Phage major tail protein; Region: Phage_tail; pfam04630 272623001367 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 272623001368 Phage-related tail protein [Function unknown]; Region: COG5283 272623001369 tape measure domain; Region: tape_meas_nterm; TIGR02675 272623001370 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 272623001371 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272623001372 catalytic residue [active] 272623001373 Phage tail protein; Region: Sipho_tail; cl11462 272623001374 Phage tail protein; Region: Sipho_tail; cl11462 272623001375 Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506 272623001376 Phage lysis protein, holin; Region: Phage_holin; cl04675 272623001377 NlpC/P60 family; Region: NLPC_P60; cl11438 272623001378 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623001379 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 272623001380 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272623001381 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 272623001382 dimerization interface 3.5A [polypeptide binding]; other site 272623001383 active site 272623001384 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272623001385 dimer interface [polypeptide binding]; other site 272623001386 substrate binding site [chemical binding]; other site 272623001387 ATP binding site [chemical binding]; other site 272623001388 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 272623001389 Protein of unknown function (DUF436); Region: DUF436; cl01860 272623001390 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272623001391 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272623001392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001393 catalytic residue [active] 272623001394 CTP synthetase; Validated; Region: pyrG; PRK05380 272623001395 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272623001396 Catalytic site [active] 272623001397 active site 272623001398 UTP binding site [chemical binding]; other site 272623001399 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272623001400 active site 272623001401 putative oxyanion hole; other site 272623001402 catalytic triad [active] 272623001403 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 272623001404 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 272623001405 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272623001406 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272623001407 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272623001408 Substrate-binding site [chemical binding]; other site 272623001409 Substrate specificity [chemical binding]; other site 272623001410 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 272623001411 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272623001412 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272623001413 generic binding surface II; other site 272623001414 generic binding surface I; other site 272623001415 Haemolysin-III related; Region: HlyIII; cl03831 272623001416 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 272623001417 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272623001418 active site 272623001419 catalytic triad [active] 272623001420 oxyanion hole [active] 272623001421 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272623001422 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 272623001423 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272623001424 IHF dimer interface [polypeptide binding]; other site 272623001425 IHF - DNA interface [nucleotide binding]; other site 272623001426 Bacteriophage bIL312 272623001427 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272623001428 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 272623001429 Int/Topo IB signature motif; other site 272623001430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623001431 non-specific DNA binding site [nucleotide binding]; other site 272623001432 salt bridge; other site 272623001433 sequence-specific DNA binding site [nucleotide binding]; other site 272623001434 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272623001435 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623001436 Helix-turn-helix domains; Region: HTH; cl00088 272623001437 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 272623001438 Virulence-associated protein E; Region: VirE; pfam05272 272623001439 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 272623001440 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 272623001441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 272623001442 DNA-binding site [nucleotide binding]; DNA binding site 272623001443 RNA-binding motif; other site 272623001444 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272623001445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623001446 Coenzyme A binding pocket [chemical binding]; other site 272623001447 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272623001448 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272623001449 DNA binding site [nucleotide binding] 272623001450 active site 272623001451 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272623001452 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272623001453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623001454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623001455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272623001456 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 272623001457 Walker A/P-loop; other site 272623001458 ATP binding site [chemical binding]; other site 272623001459 Q-loop/lid; other site 272623001460 ABC transporter signature motif; other site 272623001461 Walker B; other site 272623001462 D-loop; other site 272623001463 H-loop/switch region; other site 272623001464 LytTr DNA-binding domain; Region: LytTR; cl04498 272623001465 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272623001466 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 272623001467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001468 catalytic residue [active] 272623001469 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623001470 NlpC/P60 family; Region: NLPC_P60; cl11438 272623001471 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272623001472 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272623001473 peptide binding site [polypeptide binding]; other site 272623001474 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272623001475 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272623001476 dimer interface [polypeptide binding]; other site 272623001477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623001478 catalytic residue [active] 272623001479 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272623001480 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623001481 putative peptidoglycan binding site; other site 272623001482 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623001483 putative peptidoglycan binding site; other site 272623001484 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623001485 putative peptidoglycan binding site; other site 272623001486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623001487 Transglycosylase; Region: Transgly; cl07896 272623001488 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272623001489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623001490 Recombination protein U; Region: RecU; cl01314 272623001491 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 272623001492 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623001493 ArsC family; Region: ArsC; pfam03960 272623001494 putative catalytic residues [active] 272623001495 thiol/disulfide switch; other site 272623001496 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 272623001497 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272623001498 active site 272623001499 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272623001500 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 272623001501 hinge; other site 272623001502 active site 272623001503 trigger factor; Provisional; Region: tig; PRK01490 272623001504 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 272623001505 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272623001506 DNA primase, catalytic core; Region: dnaG; TIGR01391 272623001507 CHC2 zinc finger; Region: zf-CHC2; cl15369 272623001508 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272623001509 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272623001510 active site 272623001511 metal binding site [ion binding]; metal-binding site 272623001512 interdomain interaction site; other site 272623001513 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272623001514 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623001515 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272623001516 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272623001517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272623001518 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272623001519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272623001520 DNA binding residues [nucleotide binding] 272623001521 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623001522 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623001523 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623001524 putative active site [active] 272623001525 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272623001526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001527 putative substrate translocation pore; other site 272623001528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001529 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 272623001530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001531 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272623001532 Walker A motif; other site 272623001533 ATP binding site [chemical binding]; other site 272623001534 Walker B motif; other site 272623001535 arginine finger; other site 272623001536 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 272623001537 UvrB/uvrC motif; Region: UVR; pfam02151 272623001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001539 Walker A motif; other site 272623001540 ATP binding site [chemical binding]; other site 272623001541 Walker B motif; other site 272623001542 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 272623001543 Predicted transcriptional regulator [Transcription]; Region: COG1959 272623001544 Helix-turn-helix domains; Region: HTH; cl00088 272623001545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001546 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272623001547 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 272623001548 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272623001549 active site 272623001550 catalytic residues [active] 272623001551 metal binding site [ion binding]; metal-binding site 272623001552 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272623001553 putative active site [active] 272623001554 Ap4A binding site [chemical binding]; other site 272623001555 nudix motif; other site 272623001556 putative metal binding site [ion binding]; other site 272623001557 excinuclease ABC subunit B; Provisional; Region: PRK05298 272623001558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623001559 ATP binding site [chemical binding]; other site 272623001560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623001561 nucleotide binding region [chemical binding]; other site 272623001562 ATP-binding site [chemical binding]; other site 272623001563 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272623001564 UvrB/uvrC motif; Region: UVR; pfam02151 272623001565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623001566 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623001567 substrate binding pocket [chemical binding]; other site 272623001568 membrane-bound complex binding site; other site 272623001569 hinge residues; other site 272623001570 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 272623001571 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 272623001572 metal binding site [ion binding]; metal-binding site 272623001573 dimer interface [polypeptide binding]; other site 272623001574 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272623001575 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272623001576 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272623001577 NAD binding site [chemical binding]; other site 272623001578 homotetramer interface [polypeptide binding]; other site 272623001579 homodimer interface [polypeptide binding]; other site 272623001580 substrate binding site [chemical binding]; other site 272623001581 active site 272623001582 OxaA-like protein precursor; Provisional; Region: PRK02463 272623001583 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272623001584 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623001585 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 272623001586 Predicted membrane protein [Function unknown]; Region: COG4684 272623001587 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272623001588 Flavoprotein; Region: Flavoprotein; cl08021 272623001589 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 272623001590 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272623001591 active site 1 [active] 272623001592 dimer interface [polypeptide binding]; other site 272623001593 hexamer interface [polypeptide binding]; other site 272623001594 active site 2 [active] 272623001595 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272623001596 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623001597 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 272623001598 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623001599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272623001600 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623001601 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623001602 putative active site [active] 272623001603 TspO/MBR family; Region: TspO_MBR; cl01379 272623001604 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 272623001605 DAK2 domain; Region: Dak2; cl03685 272623001606 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 272623001607 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 272623001608 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 272623001609 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272623001610 active site 272623001611 metal binding site [ion binding]; metal-binding site 272623001612 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 272623001613 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 272623001614 DNA polymerase IV; Reviewed; Region: PRK03103 272623001615 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272623001616 active site 272623001617 DNA binding site [nucleotide binding] 272623001618 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623001619 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623001620 hypothetical protein; Provisional; Region: PRK11281 272623001621 Helix-turn-helix domains; Region: HTH; cl00088 272623001622 OsmC-like protein; Region: OsmC; cl00767 272623001623 Thymidine kinase; Region: TK; cl00631 272623001624 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272623001625 RF-1 domain; Region: RF-1; cl02875 272623001626 RF-1 domain; Region: RF-1; cl02875 272623001627 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272623001628 dimer interface [polypeptide binding]; other site 272623001629 NADPH bind site [chemical binding]; other site 272623001630 FMN binding site [chemical binding]; other site 272623001631 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272623001632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623001633 S-adenosylmethionine binding site [chemical binding]; other site 272623001634 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623001635 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 272623001636 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272623001637 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272623001638 dimer interface [polypeptide binding]; other site 272623001639 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272623001640 active site 272623001641 folate binding site [chemical binding]; other site 272623001642 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272623001643 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272623001644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623001645 catalytic residue [active] 272623001646 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272623001647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001648 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272623001649 L-serine binding site [chemical binding]; other site 272623001650 ACT domain interface; other site 272623001651 phosphoserine phosphatase SerB; Region: serB; TIGR00338 272623001652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623001653 motif II; other site 272623001654 Acylphosphatase; Region: Acylphosphatase; cl00551 272623001655 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272623001656 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 272623001657 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272623001658 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623001659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623001661 putative substrate translocation pore; other site 272623001662 Helix-turn-helix domains; Region: HTH; cl00088 272623001663 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272623001664 active site 272623001665 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 272623001666 GtrA-like protein; Region: GtrA; cl00971 272623001667 Tim44-like domain; Region: Tim44; cl09208 272623001668 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 272623001669 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 272623001670 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272623001671 DRTGG domain; Region: DRTGG; cl12147 272623001672 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272623001673 Hpr binding site; other site 272623001674 active site 272623001675 homohexamer subunit interaction site [polypeptide binding]; other site 272623001676 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 272623001677 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 272623001678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001679 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272623001680 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272623001681 K+ potassium transporter; Region: K_trans; cl15781 272623001682 Amino acid permease; Region: AA_permease; cl00524 272623001683 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623001684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001685 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272623001686 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 272623001687 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 272623001688 PQ loop repeat; Region: PQ-loop; cl12056 272623001689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623001690 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272623001691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001692 NAD(P) binding site [chemical binding]; other site 272623001693 active site 272623001694 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272623001695 DHH family; Region: DHH; pfam01368 272623001696 DHHA1 domain; Region: DHHA1; pfam02272 272623001697 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 272623001698 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 272623001699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623001700 active site 272623001701 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 272623001702 YceG-like family; Region: YceG; pfam02618 272623001703 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272623001704 dimerization interface [polypeptide binding]; other site 272623001705 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272623001706 domain; Region: GreA_GreB_N; pfam03449 272623001707 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272623001708 putative transposase OrfB; Reviewed; Region: PHA02517 272623001709 Integrase core domain; Region: rve; cl01316 272623001710 Helix-turn-helix domains; Region: HTH; cl00088 272623001711 Integrase core domain; Region: rve; cl01316 272623001712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623001714 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 272623001715 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272623001716 Clp amino terminal domain; Region: Clp_N; pfam02861 272623001717 Clp amino terminal domain; Region: Clp_N; pfam02861 272623001718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001719 Walker A motif; other site 272623001720 ATP binding site [chemical binding]; other site 272623001721 Walker B motif; other site 272623001722 arginine finger; other site 272623001723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623001724 Walker A motif; other site 272623001725 ATP binding site [chemical binding]; other site 272623001726 Walker B motif; other site 272623001727 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 272623001728 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 272623001729 30S subunit binding site; other site 272623001730 enolase; Provisional; Region: eno; PRK00077 272623001731 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272623001732 dimer interface [polypeptide binding]; other site 272623001733 metal binding site [ion binding]; metal-binding site 272623001734 substrate binding pocket [chemical binding]; other site 272623001735 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272623001736 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623001737 DNA binding site [nucleotide binding] 272623001738 Int/Topo IB signature motif; other site 272623001739 active site 272623001740 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272623001741 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272623001742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623001743 ATP binding site [chemical binding]; other site 272623001744 putative Mg++ binding site [ion binding]; other site 272623001745 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272623001746 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272623001747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001748 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272623001749 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272623001750 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272623001751 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 272623001752 putative transposase OrfB; Reviewed; Region: PHA02517 272623001753 HTH-like domain; Region: HTH_21; pfam13276 272623001754 Integrase core domain; Region: rve; cl01316 272623001755 Integrase core domain; Region: rve_3; cl15866 272623001756 enolase; Provisional; Region: eno; PRK00077 272623001757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623001758 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623001759 Walker A/P-loop; other site 272623001760 ATP binding site [chemical binding]; other site 272623001761 Q-loop/lid; other site 272623001762 ABC transporter signature motif; other site 272623001763 Walker B; other site 272623001764 D-loop; other site 272623001765 H-loop/switch region; other site 272623001766 FtsX-like permease family; Region: FtsX; pfam02687 272623001767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623001768 Helix-turn-helix domains; Region: HTH; cl00088 272623001769 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272623001770 AMP-binding enzyme; Region: AMP-binding; cl15778 272623001771 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272623001772 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272623001773 Pyruvate formate lyase 1; Region: PFL1; cd01678 272623001774 coenzyme A binding site [chemical binding]; other site 272623001775 active site 272623001776 catalytic residues [active] 272623001777 glycine loop; other site 272623001778 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272623001779 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272623001780 CoA-binding site [chemical binding]; other site 272623001781 ATP-binding [chemical binding]; other site 272623001782 drug efflux system protein MdtG; Provisional; Region: PRK09874 272623001783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001784 putative substrate translocation pore; other site 272623001785 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 272623001786 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272623001787 pyruvate carboxylase; Reviewed; Region: PRK12999 272623001788 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623001789 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623001790 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 272623001791 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272623001792 active site 272623001793 catalytic residues [active] 272623001794 metal binding site [ion binding]; metal-binding site 272623001795 homodimer binding site [polypeptide binding]; other site 272623001796 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272623001797 carboxyltransferase (CT) interaction site; other site 272623001798 biotinylation site [posttranslational modification]; other site 272623001799 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 272623001800 dimer interface [polypeptide binding]; other site 272623001801 Citrate synthase; Region: Citrate_synt; pfam00285 272623001802 active site 272623001803 citrylCoA binding site [chemical binding]; other site 272623001804 oxalacetate/citrate binding site [chemical binding]; other site 272623001805 coenzyme A binding site [chemical binding]; other site 272623001806 catalytic triad [active] 272623001807 aconitate hydratase; Validated; Region: PRK09277 272623001808 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272623001809 substrate binding site [chemical binding]; other site 272623001810 ligand binding site [chemical binding]; other site 272623001811 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272623001812 substrate binding site [chemical binding]; other site 272623001813 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272623001814 isocitrate dehydrogenase; Validated; Region: PRK07362 272623001815 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272623001816 oligomer interface [polypeptide binding]; other site 272623001817 active site residues [active] 272623001818 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623001819 ArsC family; Region: ArsC; pfam03960 272623001820 putative catalytic residues [active] 272623001821 thiol/disulfide switch; other site 272623001822 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623001823 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272623001824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623001825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623001826 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623001827 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623001828 OpgC protein; Region: OpgC_C; cl00792 272623001829 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272623001830 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272623001831 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272623001832 DXD motif; other site 272623001833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272623001834 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623001835 Integrase core domain; Region: rve; cl01316 272623001836 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 272623001837 putative active site [active] 272623001838 putative metal binding site [ion binding]; other site 272623001839 Collagen binding domain; Region: Collagen_bind; pfam05737 272623001840 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 272623001841 putative Ca2+ binding sites [ion binding]; other site 272623001842 domain interaction interfaces; other site 272623001843 putative ligand binding motif; other site 272623001844 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623001845 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 272623001846 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272623001847 active site 272623001848 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272623001849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001850 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272623001851 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272623001852 putative active site [active] 272623001853 putative metal binding site [ion binding]; other site 272623001854 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272623001855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623001856 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272623001857 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272623001858 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272623001859 active site 272623001860 elongation factor P; Validated; Region: PRK00529 272623001861 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272623001862 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272623001863 RNA binding site [nucleotide binding]; other site 272623001864 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272623001865 RNA binding site [nucleotide binding]; other site 272623001866 Protein of unknown function (DUF322); Region: DUF322; cl00574 272623001867 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272623001868 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272623001869 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272623001870 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272623001871 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272623001872 ligand binding site; other site 272623001873 oligomer interface; other site 272623001874 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272623001875 dimer interface [polypeptide binding]; other site 272623001876 N-terminal domain interface [polypeptide binding]; other site 272623001877 sulfate 1 binding site; other site 272623001878 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 272623001879 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272623001880 ligand binding site; other site 272623001881 oligomer interface; other site 272623001882 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272623001883 dimer interface [polypeptide binding]; other site 272623001884 N-terminal domain interface [polypeptide binding]; other site 272623001885 sulfate 1 binding site; other site 272623001886 glycogen synthase; Provisional; Region: glgA; PRK00654 272623001887 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272623001888 ADP-binding pocket [chemical binding]; other site 272623001889 homodimer interface [polypeptide binding]; other site 272623001890 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272623001891 homodimer interface [polypeptide binding]; other site 272623001892 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272623001893 active site pocket [active] 272623001894 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272623001895 active site 272623001896 homodimer interface [polypeptide binding]; other site 272623001897 catalytic site [active] 272623001898 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272623001899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623001900 putative substrate translocation pore; other site 272623001901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 272623001902 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623001903 Integrase core domain; Region: rve; cl01316 272623001904 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272623001905 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 272623001906 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272623001907 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272623001908 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623001909 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272623001910 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001911 Walker A/P-loop; other site 272623001912 ATP binding site [chemical binding]; other site 272623001913 Q-loop/lid; other site 272623001914 ABC transporter signature motif; other site 272623001915 Walker B; other site 272623001916 D-loop; other site 272623001917 H-loop/switch region; other site 272623001918 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272623001919 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 272623001920 Walker A/P-loop; other site 272623001921 ATP binding site [chemical binding]; other site 272623001922 Q-loop/lid; other site 272623001923 ABC transporter signature motif; other site 272623001924 Walker B; other site 272623001925 D-loop; other site 272623001926 H-loop/switch region; other site 272623001927 Helix-turn-helix domains; Region: HTH; cl00088 272623001928 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 272623001929 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623001930 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 272623001931 active site 272623001932 catalytic triad [active] 272623001933 oxyanion hole [active] 272623001934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623001935 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623001936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623001937 Walker A/P-loop; other site 272623001938 ATP binding site [chemical binding]; other site 272623001939 Q-loop/lid; other site 272623001940 ABC transporter signature motif; other site 272623001941 Walker B; other site 272623001942 D-loop; other site 272623001943 H-loop/switch region; other site 272623001944 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623001945 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272623001946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623001947 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623001948 Walker A/P-loop; other site 272623001949 ATP binding site [chemical binding]; other site 272623001950 Q-loop/lid; other site 272623001951 ABC transporter signature motif; other site 272623001952 Walker B; other site 272623001953 D-loop; other site 272623001954 H-loop/switch region; other site 272623001955 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272623001956 FtsX-like permease family; Region: FtsX; pfam02687 272623001957 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 272623001958 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 272623001959 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272623001960 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272623001961 putative NAD(P) binding site [chemical binding]; other site 272623001962 dimer interface [polypeptide binding]; other site 272623001963 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272623001964 substrate binding site [chemical binding]; other site 272623001965 THF binding site; other site 272623001966 zinc-binding site [ion binding]; other site 272623001967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623001968 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272623001969 active site 272623001970 metal binding site [ion binding]; metal-binding site 272623001971 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272623001972 nucleoside/Zn binding site; other site 272623001973 dimer interface [polypeptide binding]; other site 272623001974 catalytic motif [active] 272623001975 putative transposase OrfB; Reviewed; Region: PHA02517 272623001976 Integrase core domain; Region: rve; cl01316 272623001977 Helix-turn-helix domains; Region: HTH; cl00088 272623001978 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272623001979 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272623001980 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272623001981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623001982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623001983 DNA binding site [nucleotide binding] 272623001984 domain linker motif; other site 272623001985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623001986 dimerization interface [polypeptide binding]; other site 272623001987 ligand binding site [chemical binding]; other site 272623001988 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272623001989 CoenzymeA binding site [chemical binding]; other site 272623001990 subunit interaction site [polypeptide binding]; other site 272623001991 PHB binding site; other site 272623001992 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 272623001993 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 272623001994 active site 272623001995 octamer interface [polypeptide binding]; other site 272623001996 AMP-binding enzyme; Region: AMP-binding; cl15778 272623001997 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 272623001998 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272623001999 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 272623002000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272623002001 substrate binding site [chemical binding]; other site 272623002002 oxyanion hole (OAH) forming residues; other site 272623002003 trimer interface [polypeptide binding]; other site 272623002004 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 272623002005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623002006 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 272623002007 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272623002008 dimer interface [polypeptide binding]; other site 272623002009 tetramer interface [polypeptide binding]; other site 272623002010 PYR/PP interface [polypeptide binding]; other site 272623002011 TPP binding site [chemical binding]; other site 272623002012 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272623002013 TPP-binding site; other site 272623002014 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272623002015 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272623002016 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623002017 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623002018 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272623002019 DRTGG domain; Region: DRTGG; cl12147 272623002020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272623002021 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272623002022 DHH family; Region: DHH; pfam01368 272623002023 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272623002024 active site 272623002025 homotetramer interface [polypeptide binding]; other site 272623002026 homodimer interface [polypeptide binding]; other site 272623002027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002028 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623002029 active site 272623002030 motif I; other site 272623002031 motif II; other site 272623002032 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002033 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 272623002034 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 272623002035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 272623002036 aspartate kinase; Reviewed; Region: PRK09034 272623002037 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272623002038 putative catalytic residues [active] 272623002039 putative nucleotide binding site [chemical binding]; other site 272623002040 putative aspartate binding site [chemical binding]; other site 272623002041 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272623002042 allosteric regulatory residue; other site 272623002043 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272623002044 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272623002045 active site 272623002046 nucleophile elbow; other site 272623002047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623002048 Helix-turn-helix domains; Region: HTH; cl00088 272623002049 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272623002050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002051 motif II; other site 272623002052 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272623002053 DHH family; Region: DHH; pfam01368 272623002054 DHHA1 domain; Region: DHHA1; pfam02272 272623002055 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272623002056 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272623002057 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272623002058 replicative DNA helicase; Provisional; Region: PRK05748 272623002059 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272623002060 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272623002061 Walker A motif; other site 272623002062 ATP binding site [chemical binding]; other site 272623002063 Walker B motif; other site 272623002064 DNA binding loops [nucleotide binding] 272623002065 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 272623002066 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 272623002067 Phosphotransferase enzyme family; Region: APH; pfam01636 272623002068 active site 272623002069 substrate binding site [chemical binding]; other site 272623002070 ATP binding site [chemical binding]; other site 272623002071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623002072 S-adenosylmethionine binding site [chemical binding]; other site 272623002073 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272623002074 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 272623002075 ATP cone domain; Region: ATP-cone; pfam03477 272623002076 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272623002077 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272623002078 primosomal protein DnaI; Reviewed; Region: PRK08939 272623002079 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272623002080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623002081 Walker A motif; other site 272623002082 ATP binding site [chemical binding]; other site 272623002083 Walker B motif; other site 272623002084 arginine finger; other site 272623002085 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272623002086 dimer interface [polypeptide binding]; other site 272623002087 FMN binding site [chemical binding]; other site 272623002088 NADPH bind site [chemical binding]; other site 272623002089 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272623002090 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272623002091 GTP-binding protein Der; Reviewed; Region: PRK00093 272623002092 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272623002093 G1 box; other site 272623002094 GTP/Mg2+ binding site [chemical binding]; other site 272623002095 Switch I region; other site 272623002096 G2 box; other site 272623002097 Switch II region; other site 272623002098 G3 box; other site 272623002099 G4 box; other site 272623002100 G5 box; other site 272623002101 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272623002102 G1 box; other site 272623002103 GTP/Mg2+ binding site [chemical binding]; other site 272623002104 Switch I region; other site 272623002105 G2 box; other site 272623002106 G3 box; other site 272623002107 Switch II region; other site 272623002108 G4 box; other site 272623002109 G5 box; other site 272623002110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002111 non-specific DNA binding site [nucleotide binding]; other site 272623002112 salt bridge; other site 272623002113 sequence-specific DNA binding site [nucleotide binding]; other site 272623002114 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623002115 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 272623002116 active site 272623002117 catalytic site [active] 272623002118 LrgB-like family; Region: LrgB; cl00596 272623002119 LrgA family; Region: LrgA; cl00608 272623002120 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 272623002121 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 272623002122 Sm1 motif; other site 272623002123 predicted subunit interaction site [polypeptide binding]; other site 272623002124 RNA binding pocket [nucleotide binding]; other site 272623002125 Sm2 motif; other site 272623002126 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272623002127 NusA N-terminal domain; Region: NusA_N; pfam08529 272623002128 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272623002129 RNA binding site [nucleotide binding]; other site 272623002130 homodimer interface [polypeptide binding]; other site 272623002131 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272623002132 G-X-X-G motif; other site 272623002133 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272623002134 putative RNA binding cleft [nucleotide binding]; other site 272623002135 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272623002136 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272623002137 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623002138 translation initiation factor IF-2; Region: IF-2; TIGR00487 272623002139 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272623002140 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 272623002141 G1 box; other site 272623002142 putative GEF interaction site [polypeptide binding]; other site 272623002143 GTP/Mg2+ binding site [chemical binding]; other site 272623002144 Switch I region; other site 272623002145 G2 box; other site 272623002146 G3 box; other site 272623002147 Switch II region; other site 272623002148 G4 box; other site 272623002149 G5 box; other site 272623002150 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272623002151 Translation-initiation factor 2; Region: IF-2; pfam11987 272623002152 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272623002153 Ribosome-binding factor A; Region: RBFA; cl00542 272623002154 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272623002155 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 272623002156 Helix-turn-helix domains; Region: HTH; cl00088 272623002157 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272623002158 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272623002159 dimer interface [polypeptide binding]; other site 272623002160 active site 272623002161 CoA binding pocket [chemical binding]; other site 272623002162 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272623002163 Acyl transferase domain; Region: Acyl_transf_1; cl08282 272623002164 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272623002165 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272623002166 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272623002167 NAD(P) binding site [chemical binding]; other site 272623002168 homotetramer interface [polypeptide binding]; other site 272623002169 homodimer interface [polypeptide binding]; other site 272623002170 active site 272623002171 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272623002172 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272623002173 dimer interface [polypeptide binding]; other site 272623002174 active site 272623002175 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272623002176 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272623002177 carboxyltransferase (CT) interaction site; other site 272623002178 biotinylation site [posttranslational modification]; other site 272623002179 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272623002180 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272623002181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623002182 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623002183 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 272623002184 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272623002185 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 272623002186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 272623002187 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 272623002188 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623002189 homodimer interface [polypeptide binding]; other site 272623002190 substrate-cofactor binding pocket; other site 272623002191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002192 catalytic residue [active] 272623002193 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272623002194 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272623002195 dimer interface [polypeptide binding]; other site 272623002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002197 catalytic residue [active] 272623002198 CsbD-like; Region: CsbD; cl01888 272623002199 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623002200 active site residue [active] 272623002201 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623002202 active site residue [active] 272623002203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002204 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 272623002205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002207 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623002208 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 272623002209 active site residue [active] 272623002210 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 272623002211 putative homotetramer interface [polypeptide binding]; other site 272623002212 putative homodimer interface [polypeptide binding]; other site 272623002213 putative metal binding site [ion binding]; other site 272623002214 putative homodimer-homodimer interface [polypeptide binding]; other site 272623002215 putative allosteric switch controlling residues; other site 272623002216 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272623002217 ArsC family; Region: ArsC; pfam03960 272623002218 putative ArsC-like catalytic residues; other site 272623002219 putative TRX-like catalytic residues [active] 272623002220 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623002221 Helix-turn-helix domains; Region: HTH; cl00088 272623002222 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272623002223 active site 272623002224 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623002225 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272623002226 active site 272623002227 DNA binding site [nucleotide binding] 272623002228 putative phosphate binding site [ion binding]; other site 272623002229 putative catalytic site [active] 272623002230 metal binding site A [ion binding]; metal-binding site 272623002231 AP binding site [nucleotide binding]; other site 272623002232 metal binding site B [ion binding]; metal-binding site 272623002233 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272623002234 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272623002235 active site 272623002236 HIGH motif; other site 272623002237 KMSKS motif; other site 272623002238 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272623002239 tRNA binding surface [nucleotide binding]; other site 272623002240 anticodon binding site; other site 272623002241 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272623002242 dimer interface [polypeptide binding]; other site 272623002243 putative tRNA-binding site [nucleotide binding]; other site 272623002244 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 272623002245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272623002246 classical (c) SDRs; Region: SDR_c; cd05233 272623002247 NAD(P) binding site [chemical binding]; other site 272623002248 active site 272623002249 QueT transporter; Region: QueT; cl01932 272623002250 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 272623002251 NAD binding site [chemical binding]; other site 272623002252 substrate binding site [chemical binding]; other site 272623002253 putative active site [active] 272623002254 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 272623002255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002256 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 272623002257 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272623002258 heterotetramer interface [polypeptide binding]; other site 272623002259 active site pocket [active] 272623002260 cleavage site 272623002261 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 272623002262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272623002263 inhibitor-cofactor binding pocket; inhibition site 272623002264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623002265 catalytic residue [active] 272623002266 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272623002267 feedback inhibition sensing region; other site 272623002268 homohexameric interface [polypeptide binding]; other site 272623002269 nucleotide binding site [chemical binding]; other site 272623002270 N-acetyl-L-glutamate binding site [chemical binding]; other site 272623002271 ornithine carbamoyltransferase; Validated; Region: PRK02102 272623002272 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623002273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002274 ribonuclease III; Reviewed; Region: rnc; PRK00102 272623002275 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272623002276 dimerization interface [polypeptide binding]; other site 272623002277 active site 272623002278 metal binding site [ion binding]; metal-binding site 272623002279 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272623002280 dsRNA binding site [nucleotide binding]; other site 272623002281 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272623002282 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 272623002283 Walker A/P-loop; other site 272623002284 ATP binding site [chemical binding]; other site 272623002285 Q-loop/lid; other site 272623002286 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 272623002287 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272623002288 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 272623002289 Q-loop/lid; other site 272623002290 ABC transporter signature motif; other site 272623002291 Walker B; other site 272623002292 D-loop; other site 272623002293 H-loop/switch region; other site 272623002294 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272623002295 Sulfatase; Region: Sulfatase; cl10460 272623002296 YibE/F-like protein; Region: YibE_F; cl02259 272623002297 YibE/F-like protein; Region: YibE_F; cl02259 272623002298 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623002299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002300 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623002301 active site 272623002302 motif I; other site 272623002303 motif II; other site 272623002304 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002305 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 272623002306 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272623002307 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 272623002308 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272623002309 P loop; other site 272623002310 GTP binding site [chemical binding]; other site 272623002311 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 272623002312 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272623002313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623002314 active site 272623002315 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272623002316 Helix-turn-helix domains; Region: HTH; cl00088 272623002317 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272623002318 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272623002319 HIGH motif; other site 272623002320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623002321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623002322 active site 272623002323 KMSKS motif; other site 272623002324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272623002325 tRNA binding surface [nucleotide binding]; other site 272623002326 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272623002327 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623002328 Helix-turn-helix domains; Region: HTH; cl00088 272623002329 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623002330 putative active site [active] 272623002331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623002332 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272623002333 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623002334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623002335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272623002336 putative transposase OrfB; Reviewed; Region: PHA02517 272623002337 Integrase core domain; Region: rve; cl01316 272623002338 Helix-turn-helix domains; Region: HTH; cl00088 272623002339 putative transposase OrfB; Reviewed; Region: PHA02517 272623002340 HTH-like domain; Region: HTH_21; pfam13276 272623002341 Integrase core domain; Region: rve; cl01316 272623002342 Integrase core domain; Region: rve_3; cl15866 272623002343 Helix-turn-helix domains; Region: HTH; cl00088 272623002344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623002345 Helix-turn-helix domains; Region: HTH; cl00088 272623002346 Helix-turn-helix domains; Region: HTH; cl00088 272623002347 putative transposase OrfB; Reviewed; Region: PHA02517 272623002348 Integrase core domain; Region: rve; cl01316 272623002349 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272623002350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002352 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272623002353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002354 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272623002355 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272623002356 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272623002357 putative L-serine binding site [chemical binding]; other site 272623002358 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272623002359 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272623002360 Helix-turn-helix domains; Region: HTH; cl00088 272623002361 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 272623002362 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623002363 metal-binding site [ion binding] 272623002364 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272623002365 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623002366 metal-binding site [ion binding] 272623002367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623002368 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002369 Predicted membrane protein [Function unknown]; Region: COG4485 272623002370 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272623002371 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272623002372 nucleotide binding site/active site [active] 272623002373 HIT family signature motif; other site 272623002374 catalytic residue [active] 272623002375 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 272623002376 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272623002377 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272623002378 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272623002379 RNA binding site [nucleotide binding]; other site 272623002380 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272623002381 RNA binding site [nucleotide binding]; other site 272623002382 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 272623002383 RNA binding site [nucleotide binding]; other site 272623002384 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623002385 RNA binding site [nucleotide binding]; other site 272623002386 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272623002387 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272623002388 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272623002389 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272623002390 GIY-YIG motif/motif A; other site 272623002391 active site 272623002392 catalytic site [active] 272623002393 putative DNA binding site [nucleotide binding]; other site 272623002394 metal binding site [ion binding]; metal-binding site 272623002395 UvrB/uvrC motif; Region: UVR; pfam02151 272623002396 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272623002397 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272623002398 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272623002399 minor groove reading motif; other site 272623002400 helix-hairpin-helix signature motif; other site 272623002401 substrate binding pocket [chemical binding]; other site 272623002402 active site 272623002403 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272623002404 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272623002405 DNA binding and oxoG recognition site [nucleotide binding] 272623002406 dipeptidase PepV; Region: dipeptidase; TIGR01886 272623002407 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272623002408 active site 272623002409 metal binding site [ion binding]; metal-binding site 272623002410 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 272623002411 alanine racemase; Reviewed; Region: alr; PRK00053 272623002412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272623002413 active site 272623002414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623002415 dimer interface [polypeptide binding]; other site 272623002416 substrate binding site [chemical binding]; other site 272623002417 catalytic residues [active] 272623002418 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623002419 ArsC family; Region: ArsC; pfam03960 272623002420 putative catalytic residues [active] 272623002421 thiol/disulfide switch; other site 272623002422 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272623002423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002424 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623002425 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272623002426 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 272623002427 Walker A/P-loop; other site 272623002428 ATP binding site [chemical binding]; other site 272623002429 Q-loop/lid; other site 272623002430 ABC transporter signature motif; other site 272623002431 Walker B; other site 272623002432 D-loop; other site 272623002433 H-loop/switch region; other site 272623002434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272623002435 NMT1-like family; Region: NMT1_2; cl15260 272623002436 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272623002437 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272623002438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623002439 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002440 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272623002441 putative minor structural protein; Region: PHA01351 272623002442 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 272623002443 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272623002444 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272623002445 homodimer interface [polypeptide binding]; other site 272623002446 NADP binding site [chemical binding]; other site 272623002447 substrate binding site [chemical binding]; other site 272623002448 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272623002449 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272623002450 generic binding surface II; other site 272623002451 generic binding surface I; other site 272623002452 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 272623002453 Glycerate kinase family; Region: Gly_kinase; cl00841 272623002454 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623002455 substrate binding pocket [chemical binding]; other site 272623002456 chain length determination region; other site 272623002457 substrate-Mg2+ binding site; other site 272623002458 catalytic residues [active] 272623002459 aspartate-rich region 1; other site 272623002460 active site lid residues [active] 272623002461 aspartate-rich region 2; other site 272623002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 272623002463 Arginine repressor [Transcription]; Region: ArgR; COG1438 272623002464 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272623002465 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272623002466 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272623002467 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 272623002468 Walker A/P-loop; other site 272623002469 ATP binding site [chemical binding]; other site 272623002470 Q-loop/lid; other site 272623002471 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 272623002472 ABC transporter signature motif; other site 272623002473 Walker B; other site 272623002474 D-loop; other site 272623002475 H-loop/switch region; other site 272623002476 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623002477 Protein of unknown function (DUF805); Region: DUF805; cl01224 272623002478 Protein of unknown function (DUF805); Region: DUF805; cl01224 272623002479 Protein of unknown function (DUF805); Region: DUF805; cl01224 272623002480 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272623002481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002482 Septum formation initiator; Region: DivIC; cl11433 272623002483 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272623002484 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272623002485 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623002486 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272623002487 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272623002488 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 272623002489 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272623002490 Mg++ binding site [ion binding]; other site 272623002491 putative catalytic motif [active] 272623002492 putative substrate binding site [chemical binding]; other site 272623002493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272623002494 FtsX-like permease family; Region: FtsX; pfam02687 272623002495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623002496 Walker A/P-loop; other site 272623002497 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623002498 Q-loop/lid; other site 272623002499 ABC transporter signature motif; other site 272623002500 Walker B; other site 272623002501 D-loop; other site 272623002502 H-loop/switch region; other site 272623002503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623002504 Helix-turn-helix domains; Region: HTH; cl00088 272623002505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623002506 dimerization interface [polypeptide binding]; other site 272623002507 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272623002508 synthetase active site [active] 272623002509 NTP binding site [chemical binding]; other site 272623002510 metal binding site [ion binding]; metal-binding site 272623002511 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 272623002512 N-glycosyltransferase; Provisional; Region: PRK11204 272623002513 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272623002514 DXD motif; other site 272623002515 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 272623002516 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 272623002517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623002518 Ligand Binding Site [chemical binding]; other site 272623002519 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272623002520 IHF dimer interface [polypeptide binding]; other site 272623002521 IHF - DNA interface [nucleotide binding]; other site 272623002522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623002523 Helix-turn-helix domains; Region: HTH; cl00088 272623002524 Predicted membrane protein [Function unknown]; Region: COG1511 272623002525 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272623002526 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272623002527 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272623002528 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623002529 Domain of unknown function DUF59; Region: DUF59; cl00941 272623002530 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272623002531 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623002532 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623002533 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623002534 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 272623002535 Predicted membrane protein [Function unknown]; Region: COG4758 272623002536 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 272623002537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623002538 Histidine kinase; Region: HisKA_3; pfam07730 272623002539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002540 ATP binding site [chemical binding]; other site 272623002541 Mg2+ binding site [ion binding]; other site 272623002542 G-X-G motif; other site 272623002543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272623002544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623002545 active site 272623002546 phosphorylation site [posttranslational modification] 272623002547 intermolecular recognition site; other site 272623002548 dimerization interface [polypeptide binding]; other site 272623002549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272623002550 DNA binding residues [nucleotide binding] 272623002551 dimerization interface [polypeptide binding]; other site 272623002552 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623002553 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002554 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272623002555 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 272623002556 active site 272623002557 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 272623002558 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623002559 RNA binding site [nucleotide binding]; other site 272623002560 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272623002561 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272623002562 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272623002563 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 272623002564 putative NAD(P) binding site [chemical binding]; other site 272623002565 catalytic Zn binding site [ion binding]; other site 272623002566 acetoin reductase; Validated; Region: PRK08643 272623002567 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 272623002568 NAD binding site [chemical binding]; other site 272623002569 homotetramer interface [polypeptide binding]; other site 272623002570 homodimer interface [polypeptide binding]; other site 272623002571 active site 272623002572 substrate binding site [chemical binding]; other site 272623002573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623002574 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623002576 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002577 ABC transporter; Region: ABC_tran_2; pfam12848 272623002578 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002579 malate dehydrogenase; Provisional; Region: PRK13529 272623002580 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272623002581 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272623002582 NAD(P) binding site [chemical binding]; other site 272623002583 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 272623002584 EamA-like transporter family; Region: EamA; cl01037 272623002585 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272623002586 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272623002587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002588 motif II; other site 272623002589 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272623002590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002591 Mg2+ binding site [ion binding]; other site 272623002592 G-X-G motif; other site 272623002593 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272623002594 anchoring element; other site 272623002595 dimer interface [polypeptide binding]; other site 272623002596 ATP binding site [chemical binding]; other site 272623002597 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272623002598 active site 272623002599 putative metal-binding site [ion binding]; other site 272623002600 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272623002601 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272623002602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623002603 S-adenosylmethionine binding site [chemical binding]; other site 272623002604 Helix-turn-helix domains; Region: HTH; cl00088 272623002605 Helix-turn-helix domains; Region: HTH; cl00088 272623002606 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623002607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623002608 putative substrate translocation pore; other site 272623002609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002610 non-specific DNA binding site [nucleotide binding]; other site 272623002611 salt bridge; other site 272623002612 sequence-specific DNA binding site [nucleotide binding]; other site 272623002613 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 272623002614 Ion channel; Region: Ion_trans_2; cl11596 272623002615 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 272623002616 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272623002617 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 272623002618 Walker A/P-loop; other site 272623002619 ATP binding site [chemical binding]; other site 272623002620 Q-loop/lid; other site 272623002621 ABC transporter signature motif; other site 272623002622 Walker B; other site 272623002623 D-loop; other site 272623002624 H-loop/switch region; other site 272623002625 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623002626 putative peptidoglycan binding site; other site 272623002627 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623002628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272623002629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623002630 active site 272623002631 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002632 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002633 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002634 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002635 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272623002636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272623002637 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 272623002638 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 272623002639 active site 272623002640 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002641 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002642 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272623002643 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272623002644 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623002645 Sulfatase; Region: Sulfatase; cl10460 272623002646 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272623002647 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 272623002648 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272623002649 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272623002650 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623002651 Integrase core domain; Region: rve; cl01316 272623002652 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272623002653 Domain of unknown function (DUF74); Region: DUF74; cl00426 272623002654 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 272623002655 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272623002656 Potassium binding sites [ion binding]; other site 272623002657 Cesium cation binding sites [ion binding]; other site 272623002658 NlpC/P60 family; Region: NLPC_P60; cl11438 272623002659 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623002660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623002661 substrate binding pocket [chemical binding]; other site 272623002662 membrane-bound complex binding site; other site 272623002663 hinge residues; other site 272623002664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623002665 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272623002666 dimer interface [polypeptide binding]; other site 272623002667 conserved gate region; other site 272623002668 putative PBP binding loops; other site 272623002669 ABC-ATPase subunit interface; other site 272623002670 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623002671 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 272623002672 Walker A/P-loop; other site 272623002673 ATP binding site [chemical binding]; other site 272623002674 Q-loop/lid; other site 272623002675 ABC transporter signature motif; other site 272623002676 Walker B; other site 272623002677 D-loop; other site 272623002678 H-loop/switch region; other site 272623002679 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 272623002680 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272623002681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623002683 Preprotein translocase SecG subunit; Region: SecG; cl09123 272623002684 ribonuclease R; Region: RNase_R; TIGR02063 272623002685 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623002686 RNB domain; Region: RNB; pfam00773 272623002687 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 272623002688 RNA binding site [nucleotide binding]; other site 272623002689 Isochorismatase family; Region: Isochorismatase; pfam00857 272623002690 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623002691 catalytic triad [active] 272623002692 conserved cis-peptide bond; other site 272623002693 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272623002694 putative catalytic site [active] 272623002695 putative metal binding site [ion binding]; other site 272623002696 putative phosphate binding site [ion binding]; other site 272623002697 UbiA prenyltransferase family; Region: UbiA; cl00337 272623002698 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 272623002699 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 272623002700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623002701 catalytic core [active] 272623002702 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623002703 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272623002704 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272623002705 Helix-turn-helix domains; Region: HTH; cl00088 272623002706 HrcA protein C terminal domain; Region: HrcA; pfam01628 272623002707 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272623002708 dimer interface [polypeptide binding]; other site 272623002709 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272623002710 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272623002711 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 272623002712 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272623002713 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 272623002714 metal binding site [ion binding]; metal-binding site 272623002715 dimer interface [polypeptide binding]; other site 272623002716 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623002717 Helix-turn-helix domains; Region: HTH; cl00088 272623002718 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272623002719 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272623002720 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272623002721 putative substrate binding site [chemical binding]; other site 272623002722 putative ATP binding site [chemical binding]; other site 272623002723 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272623002724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272623002725 active site 272623002726 phosphorylation site [posttranslational modification] 272623002727 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272623002728 P-loop; other site 272623002729 active site 272623002730 phosphorylation site [posttranslational modification] 272623002731 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623002732 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272623002733 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272623002734 putative active site [active] 272623002735 catalytic site [active] 272623002736 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272623002737 putative active site [active] 272623002738 catalytic site [active] 272623002739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623002740 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 272623002741 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 272623002742 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 272623002743 dimer interface [polypeptide binding]; other site 272623002744 phosphate binding site [ion binding]; other site 272623002745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272623002746 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 272623002747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623002748 Helix-turn-helix domains; Region: HTH; cl00088 272623002749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272623002750 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 272623002751 Walker A/P-loop; other site 272623002752 ATP binding site [chemical binding]; other site 272623002753 Q-loop/lid; other site 272623002754 ABC transporter signature motif; other site 272623002755 Walker B; other site 272623002756 D-loop; other site 272623002757 H-loop/switch region; other site 272623002758 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623002759 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 272623002760 Protein of unknown function (DUF402); Region: DUF402; cl00979 272623002761 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272623002762 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272623002763 RF-1 domain; Region: RF-1; cl02875 272623002764 RF-1 domain; Region: RF-1; cl02875 272623002765 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272623002766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623002767 Walker A/P-loop; other site 272623002768 ATP binding site [chemical binding]; other site 272623002769 Q-loop/lid; other site 272623002770 ABC transporter signature motif; other site 272623002771 Walker B; other site 272623002772 D-loop; other site 272623002773 H-loop/switch region; other site 272623002774 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272623002775 FtsX-like permease family; Region: FtsX; pfam02687 272623002776 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272623002777 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272623002778 dimer interface [polypeptide binding]; other site 272623002779 putative radical transfer pathway; other site 272623002780 diiron center [ion binding]; other site 272623002781 tyrosyl radical; other site 272623002782 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 272623002783 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272623002784 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272623002785 active site 272623002786 dimer interface [polypeptide binding]; other site 272623002787 catalytic residues [active] 272623002788 effector binding site; other site 272623002789 R2 peptide binding site; other site 272623002790 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272623002791 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272623002792 Domain of unknown function (DUF205); Region: DUF205; cl00410 272623002793 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 272623002794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002795 Mg2+ binding site [ion binding]; other site 272623002796 G-X-G motif; other site 272623002797 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272623002798 anchoring element; other site 272623002799 dimer interface [polypeptide binding]; other site 272623002800 ATP binding site [chemical binding]; other site 272623002801 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272623002802 active site 272623002803 putative metal-binding site [ion binding]; other site 272623002804 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272623002805 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272623002806 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272623002807 catalytic triad [active] 272623002808 conserved cis-peptide bond; other site 272623002809 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623002810 active site 272623002811 substrate binding site [chemical binding]; other site 272623002812 catalytic site [active] 272623002813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623002814 Coenzyme A binding pocket [chemical binding]; other site 272623002815 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 272623002816 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 272623002817 CAP-like domain; other site 272623002818 active site 272623002819 primary dimer interface [polypeptide binding]; other site 272623002820 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623002821 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623002822 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272623002823 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 272623002824 cytoskeletal protein RodZ; Provisional; Region: PRK10856 272623002825 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272623002826 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272623002827 catalytic motif [active] 272623002828 Zn binding site [ion binding]; other site 272623002829 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 272623002830 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272623002831 Lumazine binding domain; Region: Lum_binding; pfam00677 272623002832 Lumazine binding domain; Region: Lum_binding; pfam00677 272623002833 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272623002834 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 272623002835 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272623002836 dimerization interface [polypeptide binding]; other site 272623002837 active site 272623002838 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272623002839 homopentamer interface [polypeptide binding]; other site 272623002840 active site 272623002841 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 272623002842 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272623002843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623002844 RNA binding surface [nucleotide binding]; other site 272623002845 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 272623002846 active site 272623002847 Divergent PAP2 family; Region: DUF212; cl00855 272623002848 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 272623002849 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272623002850 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272623002851 Ligand binding site; other site 272623002852 Putative Catalytic site; other site 272623002853 DXD motif; other site 272623002854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623002856 active site 272623002857 phosphorylation site [posttranslational modification] 272623002858 intermolecular recognition site; other site 272623002859 dimerization interface [polypeptide binding]; other site 272623002860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623002861 DNA binding site [nucleotide binding] 272623002862 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 272623002863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272623002864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623002865 dimer interface [polypeptide binding]; other site 272623002866 phosphorylation site [posttranslational modification] 272623002867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623002868 ATP binding site [chemical binding]; other site 272623002869 Mg2+ binding site [ion binding]; other site 272623002870 G-X-G motif; other site 272623002871 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272623002872 active site 272623002873 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272623002874 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272623002875 glutaminase active site [active] 272623002876 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272623002877 dimer interface [polypeptide binding]; other site 272623002878 active site 272623002879 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272623002880 dimer interface [polypeptide binding]; other site 272623002881 active site 272623002882 hypothetical protein; Reviewed; Region: PRK00024 272623002883 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272623002884 MPN+ (JAMM) motif; other site 272623002885 Zinc-binding site [ion binding]; other site 272623002886 Bacteriophage bIL285 272623002887 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623002888 Phage integrase family; Region: Phage_integrase; pfam00589 272623002889 Int/Topo IB signature motif; other site 272623002890 Bacterial membrane flanked domain; Region: DUF304; cl01348 272623002891 Domain of unknown function (DUF955); Region: DUF955; cl01076 272623002892 Helix-turn-helix domains; Region: HTH; cl00088 272623002893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623002894 ORF6N domain; Region: ORF6N; pfam10543 272623002895 ORF6C domain; Region: ORF6C; pfam10552 272623002896 Domain of unknown function (DUF771); Region: DUF771; cl09962 272623002897 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 272623002898 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 272623002899 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 272623002900 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623002901 dimer interface [polypeptide binding]; other site 272623002902 ssDNA binding site [nucleotide binding]; other site 272623002903 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623002904 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 272623002905 Endodeoxyribonuclease RusA; Region: RusA; cl01885 272623002906 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272623002907 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272623002908 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623002909 Protein of unknown function (DUF1125); Region: DUF1125; pfam06563 272623002910 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623002911 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623002912 trimer interface [polypeptide binding]; other site 272623002913 active site 272623002914 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623002915 Protein of unknown function (DUF1359); Region: DUF1359; pfam07097 272623002916 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623002917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272623002918 Phage terminase, small subunit; Region: Terminase_4; cl01525 272623002919 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623002920 Phage Terminase; Region: Terminase_1; pfam03354 272623002921 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 272623002922 Phage-related protein [Function unknown]; Region: COG4695; cl01923 272623002923 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 272623002924 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 272623002925 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272623002926 Phage capsid family; Region: Phage_capsid; pfam05065 272623002927 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 272623002928 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 272623002929 Phage-related minor tail protein [Function unknown]; Region: COG5280 272623002930 Phage-related protein [Function unknown]; Region: COG4722; cl15832 272623002931 Phage-related protein [Function unknown]; Region: PblB; COG4926 272623002932 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 272623002933 Peptidase family M23; Region: Peptidase_M23; pfam01551 272623002934 Haemolysin XhlA; Region: XhlA; pfam10779 272623002935 Phage lysis protein, holin; Region: Phage_holin; cl04675 272623002936 NlpC/P60 family; Region: NLPC_P60; cl11438 272623002937 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623002938 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 272623002939 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272623002940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002941 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623002942 ArsC family; Region: ArsC; pfam03960 272623002943 putative catalytic residues [active] 272623002944 thiol/disulfide switch; other site 272623002945 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623002946 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002947 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002948 ABC transporter; Region: ABC_tran_2; pfam12848 272623002949 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623002950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623002951 non-specific DNA binding site [nucleotide binding]; other site 272623002952 salt bridge; other site 272623002953 sequence-specific DNA binding site [nucleotide binding]; other site 272623002954 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623002955 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272623002956 dihydroorotase; Validated; Region: pyrC; PRK09357 272623002957 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272623002958 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272623002959 active site 272623002960 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272623002961 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272623002962 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272623002963 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272623002964 minor groove reading motif; other site 272623002965 helix-hairpin-helix signature motif; other site 272623002966 substrate binding pocket [chemical binding]; other site 272623002967 active site 272623002968 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272623002969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623002970 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272623002971 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 272623002972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 272623002973 sugar phosphate phosphatase; Provisional; Region: PRK10513 272623002974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623002975 active site 272623002976 motif I; other site 272623002977 motif II; other site 272623002978 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623002979 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272623002980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623002981 Zn2+ binding site [ion binding]; other site 272623002982 Mg2+ binding site [ion binding]; other site 272623002983 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 272623002984 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272623002985 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 272623002986 Protein of unknown function (DUF464); Region: DUF464; cl01080 272623002987 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 272623002988 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 272623002989 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272623002990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623002991 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272623002992 nudix motif; other site 272623002993 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 272623002994 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 272623002995 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 272623002996 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272623002997 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272623002998 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272623002999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623003000 ATP binding site [chemical binding]; other site 272623003001 putative Mg++ binding site [ion binding]; other site 272623003002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623003003 nucleotide binding region [chemical binding]; other site 272623003004 ATP-binding site [chemical binding]; other site 272623003005 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272623003006 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272623003007 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272623003008 VanZ like family; Region: VanZ; cl01971 272623003009 Integral membrane protein TerC family; Region: TerC; cl10468 272623003010 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272623003011 active site 272623003012 metal binding site [ion binding]; metal-binding site 272623003013 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272623003014 motif 1; other site 272623003015 dimer interface [polypeptide binding]; other site 272623003016 active site 272623003017 motif 2; other site 272623003018 motif 3; other site 272623003019 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272623003020 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 272623003021 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 272623003022 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 272623003023 putative Cl- selectivity filter; other site 272623003024 putative pore gating glutamate residue; other site 272623003025 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272623003026 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272623003027 active site 272623003028 (T/H)XGH motif; other site 272623003029 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272623003030 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272623003031 active site 272623003032 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623003034 Coenzyme A binding pocket [chemical binding]; other site 272623003035 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272623003036 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272623003037 homodimer interface [polypeptide binding]; other site 272623003038 NAD binding pocket [chemical binding]; other site 272623003039 ATP binding pocket [chemical binding]; other site 272623003040 Mg binding site [ion binding]; other site 272623003041 active-site loop [active] 272623003042 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623003043 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623003044 Walker A/P-loop; other site 272623003045 ATP binding site [chemical binding]; other site 272623003046 Q-loop/lid; other site 272623003047 ABC transporter signature motif; other site 272623003048 Walker B; other site 272623003049 D-loop; other site 272623003050 H-loop/switch region; other site 272623003051 FtsX-like permease family; Region: FtsX; cl15850 272623003052 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272623003053 FtsX-like permease family; Region: FtsX; cl15850 272623003054 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272623003055 catalytic triad [active] 272623003056 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272623003057 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 272623003058 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272623003059 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 272623003060 GTP-binding protein LepA; Provisional; Region: PRK05433 272623003061 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272623003062 G1 box; other site 272623003063 putative GEF interaction site [polypeptide binding]; other site 272623003064 GTP/Mg2+ binding site [chemical binding]; other site 272623003065 Switch I region; other site 272623003066 G2 box; other site 272623003067 G3 box; other site 272623003068 Switch II region; other site 272623003069 G4 box; other site 272623003070 G5 box; other site 272623003071 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272623003072 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272623003073 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272623003074 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272623003075 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272623003076 NAD(P) binding site [chemical binding]; other site 272623003077 putative active site [active] 272623003078 Amino acid permease; Region: AA_permease; cl00524 272623003079 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272623003080 DNA gyrase subunit A; Validated; Region: PRK05560 272623003081 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 272623003082 CAP-like domain; other site 272623003083 active site 272623003084 primary dimer interface [polypeptide binding]; other site 272623003085 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003086 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003087 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272623003091 ApbE family; Region: ApbE; cl00643 272623003092 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 272623003093 active site 272623003094 catalytic site [active] 272623003095 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 272623003096 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 272623003097 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272623003098 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272623003099 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 272623003100 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 272623003101 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272623003102 dimer interface [polypeptide binding]; other site 272623003103 putative anticodon binding site; other site 272623003104 Protein of unknown function (DUF998); Region: DUF998; pfam06197 272623003105 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272623003106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003107 Family description; Region: UvrD_C_2; cl15862 272623003108 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272623003109 putative active site [active] 272623003110 nucleotide binding site [chemical binding]; other site 272623003111 nudix motif; other site 272623003112 putative metal binding site [ion binding]; other site 272623003113 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 272623003114 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272623003115 dimer interface [polypeptide binding]; other site 272623003116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272623003117 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 272623003118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003119 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 272623003120 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 272623003121 RNA binding site [nucleotide binding]; other site 272623003122 active site 272623003123 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272623003124 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272623003125 active site 272623003126 Riboflavin kinase; Region: Flavokinase; cl03312 272623003127 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623003128 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623003129 dimer interface [polypeptide binding]; other site 272623003130 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003131 NAD binding site [chemical binding]; other site 272623003132 substrate binding site [chemical binding]; other site 272623003133 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 272623003134 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272623003135 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272623003136 putative active site [active] 272623003137 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623003138 active site turn [active] 272623003139 phosphorylation site [posttranslational modification] 272623003140 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623003141 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272623003142 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272623003143 HPr interaction site; other site 272623003144 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623003145 active site 272623003146 phosphorylation site [posttranslational modification] 272623003147 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623003148 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623003149 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623003150 putative active site [active] 272623003151 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272623003152 substrate binding site [chemical binding]; other site 272623003153 dimer interface [polypeptide binding]; other site 272623003154 catalytic triad [active] 272623003155 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272623003156 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272623003157 active site 272623003158 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 272623003159 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272623003160 Active Sites [active] 272623003161 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 272623003162 ParB-like nuclease domain; Region: ParBc; cl02129 272623003163 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 272623003164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623003165 FeS/SAM binding site; other site 272623003166 HemN C-terminal domain; Region: HemN_C; pfam06969 272623003167 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 272623003168 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 272623003169 active site 272623003170 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272623003171 catalytic motif [active] 272623003172 Zn binding site [ion binding]; other site 272623003173 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272623003174 active site 272623003175 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272623003176 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272623003177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623003178 active site 272623003179 motif I; other site 272623003180 motif II; other site 272623003181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623003182 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 272623003183 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272623003184 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 272623003185 active site 272623003186 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 272623003187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623003188 active site 272623003189 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 272623003190 xanthine permease; Region: pbuX; TIGR03173 272623003191 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272623003192 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272623003193 folate binding site [chemical binding]; other site 272623003194 NADP+ binding site [chemical binding]; other site 272623003195 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272623003196 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 272623003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623003198 Walker A motif; other site 272623003199 ATP binding site [chemical binding]; other site 272623003200 Walker B motif; other site 272623003201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 272623003202 Predicted GTPase [General function prediction only]; Region: COG0218 272623003203 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272623003204 G1 box; other site 272623003205 GTP/Mg2+ binding site [chemical binding]; other site 272623003206 Switch I region; other site 272623003207 G2 box; other site 272623003208 G3 box; other site 272623003209 Switch II region; other site 272623003210 G4 box; other site 272623003211 G5 box; other site 272623003212 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272623003213 active site 272623003214 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272623003215 catalytic center binding site [active] 272623003216 ATP binding site [chemical binding]; other site 272623003217 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272623003218 GTP cyclohydrolase I; Provisional; Region: PLN03044 272623003219 active site 272623003220 dihydropteroate synthase; Region: DHPS; TIGR01496 272623003221 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272623003222 substrate binding pocket [chemical binding]; other site 272623003223 dimer interface [polypeptide binding]; other site 272623003224 inhibitor binding site; inhibition site 272623003225 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272623003226 nudix motif; other site 272623003227 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272623003228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623003229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623003230 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272623003231 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272623003232 Substrate-binding site [chemical binding]; other site 272623003233 Substrate specificity [chemical binding]; other site 272623003234 homoserine dehydrogenase; Provisional; Region: PRK06349 272623003235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003236 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272623003237 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272623003238 homoserine kinase; Provisional; Region: PRK01212 272623003239 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 272623003240 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623003241 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272623003242 FAD binding domain; Region: FAD_binding_4; pfam01565 272623003243 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272623003244 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272623003245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003246 Walker A/P-loop; other site 272623003247 ATP binding site [chemical binding]; other site 272623003248 Q-loop/lid; other site 272623003249 ABC transporter signature motif; other site 272623003250 Walker B; other site 272623003251 D-loop; other site 272623003252 H-loop/switch region; other site 272623003253 TOBE domain; Region: TOBE_2; cl01440 272623003254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272623003255 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272623003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623003257 dimer interface [polypeptide binding]; other site 272623003258 conserved gate region; other site 272623003259 putative PBP binding loops; other site 272623003260 ABC-ATPase subunit interface; other site 272623003261 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272623003262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623003263 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623003264 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272623003265 B12 binding site [chemical binding]; other site 272623003266 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272623003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623003268 putative substrate translocation pore; other site 272623003269 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272623003270 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272623003271 putative active site [active] 272623003272 catalytic site [active] 272623003273 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272623003274 putative active site [active] 272623003275 catalytic site [active] 272623003276 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272623003277 putative active site cavity [active] 272623003278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623003279 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623003280 putative active site [active] 272623003281 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272623003282 TRAM domain; Region: TRAM; cl01282 272623003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003284 S-adenosylmethionine binding site [chemical binding]; other site 272623003285 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272623003286 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272623003287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003288 S-adenosylmethionine binding site [chemical binding]; other site 272623003289 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 272623003290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003291 binding surface 272623003292 TPR motif; other site 272623003293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272623003294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003295 binding surface 272623003296 TPR motif; other site 272623003297 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 272623003298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272623003299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272623003300 binding surface 272623003301 TPR motif; other site 272623003302 acetolactate synthase; Reviewed; Region: PRK08617 272623003303 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272623003304 PYR/PP interface [polypeptide binding]; other site 272623003305 dimer interface [polypeptide binding]; other site 272623003306 TPP binding site [chemical binding]; other site 272623003307 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 272623003308 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272623003309 TPP-binding site [chemical binding]; other site 272623003310 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272623003311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003312 NAD(P) binding pocket [chemical binding]; other site 272623003313 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272623003314 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272623003315 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 272623003316 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 272623003317 putative active site [active] 272623003318 (T/H)XGH motif; other site 272623003319 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 272623003320 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 272623003321 citrate lyase, alpha subunit; Region: citF; TIGR01584 272623003322 Membrane transport protein; Region: Mem_trans; cl09117 272623003323 putative transposase OrfB; Reviewed; Region: PHA02517 272623003324 HTH-like domain; Region: HTH_21; pfam13276 272623003325 Integrase core domain; Region: rve; cl01316 272623003326 Integrase core domain; Region: rve_3; cl15866 272623003327 Helix-turn-helix domains; Region: HTH; cl00088 272623003328 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272623003329 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272623003330 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003331 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003332 Helix-turn-helix domains; Region: HTH; cl00088 272623003333 similar to transposase of IS981C; tra981F 272623003334 MucBP domain; Region: MucBP; pfam06458 272623003335 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272623003336 MULE transposase domain; Region: MULE; pfam10551 272623003337 ribonuclease R; Region: RNase_R; TIGR02063 272623003338 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623003339 RNB domain; Region: RNB; pfam00773 272623003340 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 272623003341 RNA binding site [nucleotide binding]; other site 272623003342 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 272623003343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623003344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003345 homodimer interface [polypeptide binding]; other site 272623003346 catalytic residue [active] 272623003347 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 272623003348 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 272623003349 dimer interface [polypeptide binding]; other site 272623003350 motif 1; other site 272623003351 active site 272623003352 motif 2; other site 272623003353 motif 3; other site 272623003354 ATP phosphoribosyltransferase; Region: HisG; cl15266 272623003355 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272623003356 histidinol dehydrogenase; Region: hisD; TIGR00069 272623003357 NAD binding site [chemical binding]; other site 272623003358 dimerization interface [polypeptide binding]; other site 272623003359 product binding site; other site 272623003360 substrate binding site [chemical binding]; other site 272623003361 zinc binding site [ion binding]; other site 272623003362 catalytic residues [active] 272623003363 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272623003364 putative active site pocket [active] 272623003365 4-fold oligomerization interface [polypeptide binding]; other site 272623003366 metal binding residues [ion binding]; metal-binding site 272623003367 3-fold/trimer interface [polypeptide binding]; other site 272623003368 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150 272623003369 active site 272623003370 ATP binding site [chemical binding]; other site 272623003371 Phosphotransferase enzyme family; Region: APH; pfam01636 272623003372 antibiotic binding site [chemical binding]; other site 272623003373 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 272623003374 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272623003375 putative active site [active] 272623003376 oxyanion strand; other site 272623003377 catalytic triad [active] 272623003378 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272623003379 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272623003380 catalytic residues [active] 272623003381 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272623003382 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272623003383 substrate binding site [chemical binding]; other site 272623003384 glutamase interaction surface [polypeptide binding]; other site 272623003385 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272623003386 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 272623003387 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 272623003388 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 272623003389 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 272623003390 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272623003391 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272623003392 active site residue [active] 272623003393 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 272623003394 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 272623003395 tartrate dehydrogenase; Provisional; Region: PRK08194 272623003396 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272623003397 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272623003398 substrate binding site [chemical binding]; other site 272623003399 ligand binding site [chemical binding]; other site 272623003400 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272623003401 substrate binding site [chemical binding]; other site 272623003402 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272623003403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003404 Walker A/P-loop; other site 272623003405 ATP binding site [chemical binding]; other site 272623003406 Q-loop/lid; other site 272623003407 ABC transporter signature motif; other site 272623003408 Walker B; other site 272623003409 D-loop; other site 272623003410 H-loop/switch region; other site 272623003411 Dehydratase family; Region: ILVD_EDD; cl00340 272623003412 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 272623003413 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272623003414 dimer interface [polypeptide binding]; other site 272623003415 PYR/PP interface [polypeptide binding]; other site 272623003416 TPP binding site [chemical binding]; other site 272623003417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 272623003418 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272623003419 TPP-binding site [chemical binding]; other site 272623003420 dimer interface [polypeptide binding]; other site 272623003421 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272623003422 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272623003423 putative valine binding site [chemical binding]; other site 272623003424 dimer interface [polypeptide binding]; other site 272623003425 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272623003426 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272623003427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003428 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272623003429 threonine dehydratase; Validated; Region: PRK08639 272623003430 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272623003431 tetramer interface [polypeptide binding]; other site 272623003432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003433 catalytic residue [active] 272623003434 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272623003435 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 272623003436 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272623003437 homotrimer interaction site [polypeptide binding]; other site 272623003438 putative active site [active] 272623003439 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272623003440 DNA topoisomerase I; Validated; Region: PRK05582 272623003441 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272623003442 active site 272623003443 interdomain interaction site; other site 272623003444 putative metal-binding site [ion binding]; other site 272623003445 nucleotide binding site [chemical binding]; other site 272623003446 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272623003447 domain I; other site 272623003448 DNA binding groove [nucleotide binding] 272623003449 phosphate binding site [ion binding]; other site 272623003450 domain II; other site 272623003451 domain III; other site 272623003452 nucleotide binding site [chemical binding]; other site 272623003453 catalytic site [active] 272623003454 domain IV; other site 272623003455 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272623003456 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272623003457 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272623003458 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 272623003459 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 272623003460 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623003461 DNA binding site [nucleotide binding] 272623003462 Int/Topo IB signature motif; other site 272623003463 active site 272623003464 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623003465 Predicted acyl esterases [General function prediction only]; Region: COG2936 272623003466 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 272623003467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623003468 Helix-turn-helix domains; Region: HTH; cl00088 272623003469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623003470 dimerization interface [polypeptide binding]; other site 272623003471 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 272623003472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003473 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272623003474 Asp23 family; Region: Asp23; cl00574 272623003475 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 272623003476 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 272623003477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623003478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272623003479 active site 272623003480 catalytic tetrad [active] 272623003481 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623003482 amphipathic channel; other site 272623003483 Asn-Pro-Ala signature motifs; other site 272623003484 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272623003485 glycerol kinase; Provisional; Region: glpK; PRK00047 272623003486 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272623003487 N- and C-terminal domain interface [polypeptide binding]; other site 272623003488 active site 272623003489 MgATP binding site [chemical binding]; other site 272623003490 catalytic site [active] 272623003491 metal binding site [ion binding]; metal-binding site 272623003492 glycerol binding site [chemical binding]; other site 272623003493 homotetramer interface [polypeptide binding]; other site 272623003494 homodimer interface [polypeptide binding]; other site 272623003495 FBP binding site [chemical binding]; other site 272623003496 protein IIAGlc interface [polypeptide binding]; other site 272623003497 Helix-turn-helix domains; Region: HTH; cl00088 272623003498 putative transposase OrfB; Reviewed; Region: PHA02517 272623003499 Integrase core domain; Region: rve; cl01316 272623003500 Helix-turn-helix domains; Region: HTH; cl00088 272623003501 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 272623003502 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 272623003503 active site 272623003504 Na/Ca binding site [ion binding]; other site 272623003505 catalytic site [active] 272623003506 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 272623003507 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 272623003508 teramer interface [polypeptide binding]; other site 272623003509 active site 272623003510 FMN binding site [chemical binding]; other site 272623003511 catalytic residues [active] 272623003512 NeuB family; Region: NeuB; cl00496 272623003513 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272623003514 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272623003515 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 272623003516 FAD binding site [chemical binding]; other site 272623003517 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272623003518 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272623003519 THF binding site; other site 272623003520 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272623003521 substrate binding site [chemical binding]; other site 272623003522 THF binding site; other site 272623003523 zinc-binding site [ion binding]; other site 272623003524 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 272623003525 Helix-turn-helix domains; Region: HTH; cl00088 272623003526 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272623003527 magnesium-transporting ATPase; Provisional; Region: PRK15122 272623003528 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272623003529 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623003530 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623003531 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623003532 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623003533 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 272623003534 DltD N-terminal region; Region: DltD_N; pfam04915 272623003535 DltD central region; Region: DltD_M; pfam04918 272623003536 DltD C-terminal region; Region: DltD_C; pfam04914 272623003537 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272623003538 MBOAT family; Region: MBOAT; cl00738 272623003539 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 272623003540 AMP-binding enzyme; Region: AMP-binding; cl15778 272623003541 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272623003542 thiamine phosphate binding site [chemical binding]; other site 272623003543 active site 272623003544 pyrophosphate binding site [ion binding]; other site 272623003545 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272623003546 substrate binding site [chemical binding]; other site 272623003547 dimer interface [polypeptide binding]; other site 272623003548 ATP binding site [chemical binding]; other site 272623003549 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272623003550 substrate binding site [chemical binding]; other site 272623003551 multimerization interface [polypeptide binding]; other site 272623003552 ATP binding site [chemical binding]; other site 272623003553 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272623003554 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 272623003555 DXD motif; other site 272623003556 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272623003557 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272623003558 active site 272623003559 homodimer interface [polypeptide binding]; other site 272623003560 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272623003561 core dimer interface [polypeptide binding]; other site 272623003562 peripheral dimer interface [polypeptide binding]; other site 272623003563 L10 interface [polypeptide binding]; other site 272623003564 L11 interface [polypeptide binding]; other site 272623003565 putative EF-Tu interaction site [polypeptide binding]; other site 272623003566 putative EF-G interaction site [polypeptide binding]; other site 272623003567 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272623003568 23S rRNA interface [nucleotide binding]; other site 272623003569 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272623003570 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272623003571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003572 non-specific DNA binding site [nucleotide binding]; other site 272623003573 salt bridge; other site 272623003574 sequence-specific DNA binding site [nucleotide binding]; other site 272623003575 Predicted transcriptional regulator [Transcription]; Region: COG2932 272623003576 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272623003577 Catalytic site [active] 272623003578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623003579 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623003580 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 272623003581 Walker A/P-loop; other site 272623003582 ATP binding site [chemical binding]; other site 272623003583 Q-loop/lid; other site 272623003584 ABC transporter signature motif; other site 272623003585 Walker B; other site 272623003586 D-loop; other site 272623003587 H-loop/switch region; other site 272623003588 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623003589 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272623003590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003591 Walker A/P-loop; other site 272623003592 ATP binding site [chemical binding]; other site 272623003593 Q-loop/lid; other site 272623003594 ABC transporter signature motif; other site 272623003595 Walker B; other site 272623003596 D-loop; other site 272623003597 H-loop/switch region; other site 272623003598 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 272623003599 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272623003600 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272623003601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623003602 RNA binding surface [nucleotide binding]; other site 272623003603 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 272623003604 active site 272623003605 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272623003606 ScpA/B protein; Region: ScpA_ScpB; cl00598 272623003607 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 272623003608 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 272623003609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272623003610 FOG: CBS domain [General function prediction only]; Region: COG0517 272623003611 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272623003612 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272623003613 active site 272623003614 metal binding site [ion binding]; metal-binding site 272623003615 homotetramer interface [polypeptide binding]; other site 272623003616 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272623003617 active site 272623003618 dimerization interface [polypeptide binding]; other site 272623003619 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272623003620 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 272623003621 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 272623003622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272623003623 active site 272623003624 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623003625 substrate binding site [chemical binding]; other site 272623003626 catalytic residues [active] 272623003627 dimer interface [polypeptide binding]; other site 272623003628 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272623003629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003630 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272623003631 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272623003632 active site 272623003633 dimer interface [polypeptide binding]; other site 272623003634 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272623003635 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272623003636 active site 272623003637 FMN binding site [chemical binding]; other site 272623003638 substrate binding site [chemical binding]; other site 272623003639 3Fe-4S cluster binding site [ion binding]; other site 272623003640 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272623003641 domain interface; other site 272623003642 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 272623003643 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623003644 active site 272623003645 substrate binding site [chemical binding]; other site 272623003646 trimer interface [polypeptide binding]; other site 272623003647 CoA binding site [chemical binding]; other site 272623003648 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272623003649 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272623003650 homodimer interface [polypeptide binding]; other site 272623003651 substrate-cofactor binding pocket; other site 272623003652 catalytic residue [active] 272623003653 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272623003654 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 272623003655 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272623003656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003657 catalytic residue [active] 272623003658 Amino acid permease; Region: AA_permease; cl00524 272623003659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623003660 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623003661 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272623003662 RNA/DNA hybrid binding site [nucleotide binding]; other site 272623003663 active site 272623003664 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272623003665 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 272623003666 GTP/Mg2+ binding site [chemical binding]; other site 272623003667 G4 box; other site 272623003668 G5 box; other site 272623003669 G1 box; other site 272623003670 Switch I region; other site 272623003671 G2 box; other site 272623003672 G3 box; other site 272623003673 Switch II region; other site 272623003674 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623003675 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623003676 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272623003677 Helix-turn-helix domains; Region: HTH; cl00088 272623003678 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272623003679 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272623003680 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 272623003681 active site 272623003682 Protein of unknown function (DUF805); Region: DUF805; cl01224 272623003683 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272623003684 MucBP domain; Region: MucBP; pfam06458 272623003685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272623003686 YodA lipocalin-like domain; Region: YodA; cl01365 272623003687 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623003688 Integrase core domain; Region: rve; cl01316 272623003689 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272623003690 dimer interface [polypeptide binding]; other site 272623003691 PYR/PP interface [polypeptide binding]; other site 272623003692 TPP binding site [chemical binding]; other site 272623003693 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 272623003694 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272623003695 TPP-binding site [chemical binding]; other site 272623003696 Helix-turn-helix domains; Region: HTH; cl00088 272623003697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623003698 Helix-turn-helix domains; Region: HTH; cl00088 272623003699 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272623003700 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623003701 substrate binding pocket [chemical binding]; other site 272623003702 short chain dehydrogenase; Validated; Region: PRK06182 272623003703 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623003704 NADP binding site [chemical binding]; other site 272623003705 active site 272623003706 steroid binding site; other site 272623003707 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 272623003708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272623003709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623003710 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 272623003711 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272623003712 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272623003713 ArsC family; Region: ArsC; pfam03960 272623003714 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272623003715 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272623003716 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272623003717 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 272623003718 substrate-cofactor binding pocket; other site 272623003719 homodimer interface [polypeptide binding]; other site 272623003720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623003721 catalytic residue [active] 272623003722 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272623003723 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272623003724 glutamine binding [chemical binding]; other site 272623003725 catalytic triad [active] 272623003726 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272623003727 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272623003728 metal binding site [ion binding]; metal-binding site 272623003729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623003730 ABC-ATPase subunit interface; other site 272623003731 dimer interface [polypeptide binding]; other site 272623003732 putative PBP binding regions; other site 272623003733 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272623003734 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 272623003735 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272623003736 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 272623003737 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272623003738 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 272623003739 Walker A/P-loop; other site 272623003740 ATP binding site [chemical binding]; other site 272623003741 Q-loop/lid; other site 272623003742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003743 ABC transporter signature motif; other site 272623003744 Walker B; other site 272623003745 D-loop; other site 272623003746 H-loop/switch region; other site 272623003747 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272623003748 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272623003749 active site 272623003750 metal binding site [ion binding]; metal-binding site 272623003751 DNA binding site [nucleotide binding] 272623003752 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272623003753 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272623003754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003755 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272623003756 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272623003757 ArsC family; Region: ArsC; pfam03960 272623003758 putative catalytic residues [active] 272623003759 thiol/disulfide switch; other site 272623003760 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 272623003761 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623003762 Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488 272623003763 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 272623003764 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 272623003765 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272623003766 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272623003767 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 272623003768 Walker A/P-loop; other site 272623003769 ATP binding site [chemical binding]; other site 272623003770 Q-loop/lid; other site 272623003771 ABC transporter signature motif; other site 272623003772 Walker B; other site 272623003773 D-loop; other site 272623003774 H-loop/switch region; other site 272623003775 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 272623003776 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272623003777 TM-ABC transporter signature motif; other site 272623003778 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272623003779 TM-ABC transporter signature motif; other site 272623003780 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272623003781 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272623003782 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003783 NAD binding site [chemical binding]; other site 272623003784 dimer interface [polypeptide binding]; other site 272623003785 substrate binding site [chemical binding]; other site 272623003786 pyruvate kinase; Provisional; Region: PRK05826 272623003787 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272623003788 domain interfaces; other site 272623003789 active site 272623003790 6-phosphofructokinase; Provisional; Region: PRK03202 272623003791 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272623003792 active site 272623003793 ADP/pyrophosphate binding site [chemical binding]; other site 272623003794 dimerization interface [polypeptide binding]; other site 272623003795 allosteric effector site; other site 272623003796 fructose-1,6-bisphosphate binding site; other site 272623003797 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 272623003798 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272623003799 active site 272623003800 dimer interface [polypeptide binding]; other site 272623003801 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272623003802 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 272623003803 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272623003804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623003805 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272623003806 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 272623003807 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272623003808 active site 272623003809 tetramer interface; other site 272623003810 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 272623003811 trimer interface [polypeptide binding]; other site 272623003812 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 272623003813 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272623003814 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272623003815 substrate binding pocket [chemical binding]; other site 272623003816 chain length determination region; other site 272623003817 substrate-Mg2+ binding site; other site 272623003818 catalytic residues [active] 272623003819 aspartate-rich region 1; other site 272623003820 active site lid residues [active] 272623003821 aspartate-rich region 2; other site 272623003822 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 272623003823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623003824 S-adenosylmethionine binding site [chemical binding]; other site 272623003825 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 272623003826 active site 272623003827 dimer interface [polypeptide binding]; other site 272623003828 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 272623003829 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272623003830 heterodimer interface [polypeptide binding]; other site 272623003831 active site 272623003832 FMN binding site [chemical binding]; other site 272623003833 homodimer interface [polypeptide binding]; other site 272623003834 substrate binding site [chemical binding]; other site 272623003835 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272623003836 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272623003837 FAD binding pocket [chemical binding]; other site 272623003838 FAD binding motif [chemical binding]; other site 272623003839 phosphate binding motif [ion binding]; other site 272623003840 beta-alpha-beta structure motif; other site 272623003841 NAD binding pocket [chemical binding]; other site 272623003842 Iron coordination center [ion binding]; other site 272623003843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623003844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623003845 putative substrate translocation pore; other site 272623003846 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 272623003847 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 272623003848 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 272623003849 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 272623003850 Domain of unknown function (DUF477); Region: DUF477; cl01535 272623003851 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 272623003852 pseudouridine synthase; Region: TIGR00093 272623003853 active site 272623003854 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003855 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003856 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623003857 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623003858 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623003859 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623003860 Integrase core domain; Region: rve; cl01316 272623003861 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623003862 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272623003863 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623003864 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623003865 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272623003866 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272623003867 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623003868 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272623003869 IMP binding site; other site 272623003870 dimer interface [polypeptide binding]; other site 272623003871 interdomain contacts; other site 272623003872 partial ornithine binding site; other site 272623003873 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272623003874 catalytic residues [active] 272623003875 dimer interface [polypeptide binding]; other site 272623003876 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 272623003877 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623003878 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272623003879 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623003880 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272623003881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623003882 motif II; other site 272623003883 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623003884 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272623003885 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623003886 TraX protein; Region: TraX; cl05434 272623003887 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 272623003888 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623003889 Ligand Binding Site [chemical binding]; other site 272623003890 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272623003891 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 272623003892 active site 272623003893 Bacteriophage bIL286 272623003894 NlpC/P60 family; Region: NLPC_P60; cl11438 272623003895 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272623003896 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 272623003897 Phage lysis protein, holin; Region: Phage_holin; cl04675 272623003898 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272623003899 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272623003900 Haemolysin XhlA; Region: XhlA; pfam10779 272623003901 Phage-related protein [Function unknown]; Region: COG4722; cl15832 272623003902 Phage tail protein; Region: Sipho_tail; pfam05709 272623003903 Phage-related tail protein [Function unknown]; Region: COG5283 272623003904 Phage-related tail protein [Function unknown]; Region: COG5283 272623003905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 272623003906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272623003907 catalytic residue [active] 272623003908 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 272623003909 Phage major tail protein; Region: Phage_tail; pfam04630 272623003910 Protein of unknown function (DUF806); Region: DUF806; pfam05657 272623003911 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 272623003912 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 272623003913 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272623003914 oligomerization interface [polypeptide binding]; other site 272623003915 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272623003916 Phage capsid family; Region: Phage_capsid; pfam05065 272623003917 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272623003918 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 272623003919 oligomer interface [polypeptide binding]; other site 272623003920 active site residues [active] 272623003921 Phage-related protein [Function unknown]; Region: COG4695; cl01923 272623003922 Phage portal protein; Region: Phage_portal; pfam04860 272623003923 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 272623003924 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272623003925 Phage Terminase; Region: Terminase_1; pfam03354 272623003926 Phage terminase, small subunit; Region: Terminase_4; cl01525 272623003927 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272623003928 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272623003929 Prophage protein (DUF1660); Region: DUF1660; pfam07874 272623003930 Protein of unknown function (DUF1140); Region: DUF1140; pfam06600 272623003931 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272623003932 trimer interface [polypeptide binding]; other site 272623003933 active site 272623003934 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272623003935 cell division protein MukB; Provisional; Region: mukB; PRK04863 272623003936 Protein of unknown function (DUF658); Region: DUF658; pfam04936 272623003937 Protein of unknown function (DUF1497); Region: DUF1497; pfam07384 272623003938 Protein of unknown function (DUF1031); Region: DUF1031; pfam06275 272623003939 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 272623003940 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272623003941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623003942 Putative replisome organiser protein C-terminus; Region: Rep_Org_C; pfam06926 272623003943 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623003944 dimer interface [polypeptide binding]; other site 272623003945 ssDNA binding site [nucleotide binding]; other site 272623003946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623003947 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 272623003948 Protein of unknown function (DUF1408); Region: DUF1408; pfam07193 272623003949 AntA/AntB antirepressor; Region: AntA; cl01430 272623003950 ORF6C domain; Region: ORF6C; pfam10552 272623003951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003952 non-specific DNA binding site [nucleotide binding]; other site 272623003953 salt bridge; other site 272623003954 sequence-specific DNA binding site [nucleotide binding]; other site 272623003955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623003956 non-specific DNA binding site [nucleotide binding]; other site 272623003957 salt bridge; other site 272623003958 sequence-specific DNA binding site [nucleotide binding]; other site 272623003959 Lactococcus bacteriophage repressor; Region: Lac_bphage_repr; pfam06543 272623003960 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623003961 Phage integrase family; Region: Phage_integrase; pfam00589 272623003962 Int/Topo IB signature motif; other site 272623003963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623003964 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 272623003965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623003967 active site 272623003968 phosphorylation site [posttranslational modification] 272623003969 intermolecular recognition site; other site 272623003970 dimerization interface [polypeptide binding]; other site 272623003971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623003972 DNA binding site [nucleotide binding] 272623003973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272623003974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623003975 dimer interface [polypeptide binding]; other site 272623003976 phosphorylation site [posttranslational modification] 272623003977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623003978 ATP binding site [chemical binding]; other site 272623003979 Mg2+ binding site [ion binding]; other site 272623003980 G-X-G motif; other site 272623003981 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 272623003982 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272623003983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623003984 DNA-binding site [nucleotide binding]; DNA binding site 272623003985 UTRA domain; Region: UTRA; cl01230 272623003986 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272623003987 ligand binding site [chemical binding]; other site 272623003988 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272623003989 active site 272623003990 catalytic motif [active] 272623003991 Zn binding site [ion binding]; other site 272623003992 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272623003993 intersubunit interface [polypeptide binding]; other site 272623003994 active site 272623003995 catalytic residue [active] 272623003996 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272623003997 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272623003998 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272623003999 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 272623004000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623004001 S-adenosylmethionine binding site [chemical binding]; other site 272623004002 pantothenate kinase; Provisional; Region: PRK05439 272623004003 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 272623004004 ATP-binding site [chemical binding]; other site 272623004005 CoA-binding site [chemical binding]; other site 272623004006 Mg2+-binding site [ion binding]; other site 272623004007 Phosphate-starvation-inducible E; Region: PsiE; cl01264 272623004008 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272623004009 Cation efflux family; Region: Cation_efflux; cl00316 272623004010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004011 non-specific DNA binding site [nucleotide binding]; other site 272623004012 salt bridge; other site 272623004013 sequence-specific DNA binding site [nucleotide binding]; other site 272623004014 ParB-like nuclease domain; Region: ParBc; cl02129 272623004015 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272623004016 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 272623004017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004018 dimer interface [polypeptide binding]; other site 272623004019 conserved gate region; other site 272623004020 putative PBP binding loops; other site 272623004021 ABC-ATPase subunit interface; other site 272623004022 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 272623004023 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272623004024 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272623004025 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 272623004026 Walker A/P-loop; other site 272623004027 ATP binding site [chemical binding]; other site 272623004028 Q-loop/lid; other site 272623004029 ABC transporter signature motif; other site 272623004030 Walker B; other site 272623004031 D-loop; other site 272623004032 H-loop/switch region; other site 272623004033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 272623004034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004035 DNA-binding site [nucleotide binding]; DNA binding site 272623004036 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 272623004037 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 272623004038 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 272623004039 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 272623004040 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 272623004041 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 272623004042 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 272623004043 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272623004044 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272623004045 active site 272623004046 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623004047 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272623004048 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272623004049 active site turn [active] 272623004050 phosphorylation site [posttranslational modification] 272623004051 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 272623004052 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272623004053 HPr interaction site; other site 272623004054 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272623004055 active site 272623004056 phosphorylation site [posttranslational modification] 272623004057 CAT RNA binding domain; Region: CAT_RBD; cl03904 272623004058 PRD domain; Region: PRD; cl15445 272623004059 PRD domain; Region: PRD; cl15445 272623004060 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272623004061 substrate binding site [chemical binding]; other site 272623004062 active site 272623004063 catalytic residues [active] 272623004064 heterodimer interface [polypeptide binding]; other site 272623004065 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272623004066 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 272623004067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623004068 catalytic residue [active] 272623004069 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272623004070 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 272623004071 active site 272623004072 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272623004073 active site 272623004074 ribulose/triose binding site [chemical binding]; other site 272623004075 phosphate binding site [ion binding]; other site 272623004076 substrate (anthranilate) binding pocket [chemical binding]; other site 272623004077 product (indole) binding pocket [chemical binding]; other site 272623004078 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272623004079 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272623004080 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272623004081 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272623004082 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272623004083 glutamine binding [chemical binding]; other site 272623004084 catalytic triad [active] 272623004085 anthranilate synthase component I; Provisional; Region: PRK13570 272623004086 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272623004087 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272623004088 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 272623004089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623004090 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004091 putative DNA binding site [nucleotide binding]; other site 272623004092 putative Zn2+ binding site [ion binding]; other site 272623004093 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272623004094 dimer interface [polypeptide binding]; other site 272623004095 FMN binding site [chemical binding]; other site 272623004096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623004097 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272623004098 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272623004099 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272623004100 metal binding site 2 [ion binding]; metal-binding site 272623004101 putative DNA binding helix; other site 272623004102 metal binding site 1 [ion binding]; metal-binding site 272623004103 dimer interface [polypeptide binding]; other site 272623004104 structural Zn2+ binding site [ion binding]; other site 272623004105 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 272623004106 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272623004107 EamA-like transporter family; Region: EamA; cl01037 272623004108 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623004109 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623004110 DNA binding residues [nucleotide binding] 272623004111 putative dimer interface [polypeptide binding]; other site 272623004112 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272623004113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004114 NAD(P) binding site [chemical binding]; other site 272623004115 active site 272623004116 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272623004117 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272623004118 TPP-binding site; other site 272623004119 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004120 PYR/PP interface [polypeptide binding]; other site 272623004121 dimer interface [polypeptide binding]; other site 272623004122 TPP binding site [chemical binding]; other site 272623004123 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623004125 Helix-turn-helix domains; Region: HTH; cl00088 272623004126 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272623004127 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272623004128 MatE; Region: MatE; cl10513 272623004129 MatE; Region: MatE; cl10513 272623004130 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004131 GMP synthase; Reviewed; Region: guaA; PRK00074 272623004132 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272623004133 AMP/PPi binding site [chemical binding]; other site 272623004134 candidate oxyanion hole; other site 272623004135 catalytic triad [active] 272623004136 potential glutamine specificity residues [chemical binding]; other site 272623004137 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272623004138 ATP Binding subdomain [chemical binding]; other site 272623004139 Dimerization subdomain; other site 272623004140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272623004141 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272623004142 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272623004143 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272623004144 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623004145 Protein of unknown function, DUF624; Region: DUF624; cl02369 272623004146 FOG: PKD repeat [General function prediction only]; Region: COG3291 272623004147 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 272623004148 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 272623004149 sugar binding site [chemical binding]; other site 272623004150 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...; Region: GH85_ENGase; cd06547 272623004151 putative active site [active] 272623004152 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004153 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004154 Ca binding site [ion binding]; other site 272623004155 active site 272623004156 catalytic site [active] 272623004157 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 272623004158 active site 272623004159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272623004160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623004161 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 272623004162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272623004163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004164 dimer interface [polypeptide binding]; other site 272623004165 conserved gate region; other site 272623004166 putative PBP binding loops; other site 272623004167 ABC-ATPase subunit interface; other site 272623004168 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272623004169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272623004170 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272623004171 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 272623004172 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 272623004173 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 272623004174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004175 DNA-binding site [nucleotide binding]; DNA binding site 272623004176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004177 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623004178 ligand binding site [chemical binding]; other site 272623004179 dimerization interface [polypeptide binding]; other site 272623004180 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 272623004181 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 272623004182 putative phosphoketolase; Provisional; Region: PRK05261 272623004183 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272623004184 TPP-binding site [chemical binding]; other site 272623004185 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 272623004186 XFP C-terminal domain; Region: XFP_C; pfam09363 272623004187 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272623004188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004189 putative substrate translocation pore; other site 272623004190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004191 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272623004192 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623004193 active site 272623004194 substrate binding site [chemical binding]; other site 272623004195 trimer interface [polypeptide binding]; other site 272623004196 CoA binding site [chemical binding]; other site 272623004197 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272623004198 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272623004199 inhibitor binding site; inhibition site 272623004200 active site 272623004201 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004202 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 272623004203 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 272623004204 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272623004205 active site 272623004206 catalytic residues [active] 272623004207 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272623004208 N- and C-terminal domain interface [polypeptide binding]; other site 272623004209 D-xylulose kinase; Region: XylB; TIGR01312 272623004210 active site 272623004211 catalytic site [active] 272623004212 metal binding site [ion binding]; metal-binding site 272623004213 xylulose binding site [chemical binding]; other site 272623004214 putative ATP binding site [chemical binding]; other site 272623004215 homodimer interface [polypeptide binding]; other site 272623004216 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 272623004217 Cupin domain; Region: Cupin_2; cl09118 272623004218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623004219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272623004220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272623004221 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272623004222 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 272623004223 AIR carboxylase; Region: AIRC; cl00310 272623004224 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272623004225 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272623004226 ATP-grasp domain; Region: ATP-grasp_4; cl03087 272623004227 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272623004228 tetracycline repressor protein TetR; Provisional; Region: PRK13756 272623004229 Helix-turn-helix domains; Region: HTH; cl00088 272623004230 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 272623004231 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623004232 Integrase core domain; Region: rve; cl01316 272623004233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623004235 putative substrate translocation pore; other site 272623004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004237 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 272623004238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004239 motif II; other site 272623004240 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272623004241 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272623004242 purine monophosphate binding site [chemical binding]; other site 272623004243 dimer interface [polypeptide binding]; other site 272623004244 putative catalytic residues [active] 272623004245 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272623004246 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272623004247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004248 active site 272623004249 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272623004250 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 272623004251 NADP binding site [chemical binding]; other site 272623004252 putative substrate binding site [chemical binding]; other site 272623004253 active site 272623004254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272623004255 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 272623004256 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 272623004257 Walker A/P-loop; other site 272623004258 ATP binding site [chemical binding]; other site 272623004259 Q-loop/lid; other site 272623004260 ABC transporter signature motif; other site 272623004261 Walker B; other site 272623004262 D-loop; other site 272623004263 H-loop/switch region; other site 272623004264 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272623004265 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272623004266 active site 272623004267 substrate binding site [chemical binding]; other site 272623004268 cosubstrate binding site; other site 272623004269 catalytic site [active] 272623004270 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272623004271 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272623004272 dimerization interface [polypeptide binding]; other site 272623004273 putative ATP binding site [chemical binding]; other site 272623004274 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272623004275 Clp amino terminal domain; Region: Clp_N; pfam02861 272623004276 Clp amino terminal domain; Region: Clp_N; pfam02861 272623004277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623004278 Walker A motif; other site 272623004279 ATP binding site [chemical binding]; other site 272623004280 Walker B motif; other site 272623004281 arginine finger; other site 272623004282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623004283 Walker A motif; other site 272623004284 ATP binding site [chemical binding]; other site 272623004285 Walker B motif; other site 272623004286 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 272623004287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004288 NAD(P) binding site [chemical binding]; other site 272623004289 active site 272623004290 amidophosphoribosyltransferase; Provisional; Region: PRK07272 272623004291 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272623004292 active site 272623004293 tetramer interface [polypeptide binding]; other site 272623004294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004295 active site 272623004296 short chain dehydrogenase; Provisional; Region: PRK06180 272623004297 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272623004298 NADP binding site [chemical binding]; other site 272623004299 active site 272623004300 steroid binding site; other site 272623004301 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272623004302 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272623004303 dimerization interface [polypeptide binding]; other site 272623004304 ATP binding site [chemical binding]; other site 272623004305 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272623004306 dimerization interface [polypeptide binding]; other site 272623004307 ATP binding site [chemical binding]; other site 272623004308 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272623004309 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 272623004310 putative active site [active] 272623004311 catalytic triad [active] 272623004312 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 272623004313 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272623004314 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272623004315 ATP binding site [chemical binding]; other site 272623004316 active site 272623004317 substrate binding site [chemical binding]; other site 272623004318 Cupin domain; Region: Cupin_2; cl09118 272623004319 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 272623004320 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272623004321 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 272623004322 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272623004323 classical (c) SDRs; Region: SDR_c; cd05233 272623004324 NAD(P) binding site [chemical binding]; other site 272623004325 active site 272623004326 putative transporter; Provisional; Region: PRK10504 272623004327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004328 putative substrate translocation pore; other site 272623004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004330 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623004331 Helix-turn-helix domains; Region: HTH; cl00088 272623004332 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272623004333 dimerization interface [polypeptide binding]; other site 272623004334 active site 272623004335 putative transposase OrfB; Reviewed; Region: PHA02517 272623004336 Integrase core domain; Region: rve; cl01316 272623004337 Helix-turn-helix domains; Region: HTH; cl00088 272623004338 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 272623004339 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272623004340 catalytic Zn binding site [ion binding]; other site 272623004341 NAD(P) binding site [chemical binding]; other site 272623004342 structural Zn binding site [ion binding]; other site 272623004343 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004344 Predicted membrane protein [Function unknown]; Region: COG4905 272623004345 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 272623004346 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 272623004347 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 272623004348 active site 272623004349 FMN binding site [chemical binding]; other site 272623004350 substrate binding site [chemical binding]; other site 272623004351 catalytic residues [active] 272623004352 homodimer interface [polypeptide binding]; other site 272623004353 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 272623004354 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272623004355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004356 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 272623004357 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272623004358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623004359 Walker A/P-loop; other site 272623004360 ATP binding site [chemical binding]; other site 272623004361 Q-loop/lid; other site 272623004362 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623004363 ABC transporter signature motif; other site 272623004364 Walker B; other site 272623004365 D-loop; other site 272623004366 ABC transporter; Region: ABC_tran_2; pfam12848 272623004367 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 272623004368 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272623004369 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272623004370 putative active site [active] 272623004371 metal binding site [ion binding]; metal-binding site 272623004372 Peptidase family C69; Region: Peptidase_C69; cl01920 272623004373 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272623004374 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272623004375 active site 272623004376 NTP binding site [chemical binding]; other site 272623004377 metal binding triad [ion binding]; metal-binding site 272623004378 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272623004379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623004380 Predicted acetyltransferase [General function prediction only]; Region: COG3981 272623004381 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623004382 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272623004383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004384 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272623004385 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 272623004386 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 272623004387 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 272623004388 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272623004389 RimM N-terminal domain; Region: RimM; pfam01782 272623004390 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 272623004391 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272623004392 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623004393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623004394 Ferrochelatase; Region: Ferrochelatase; pfam00762 272623004395 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272623004396 C-terminal domain interface [polypeptide binding]; other site 272623004397 active site 272623004398 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272623004399 active site 272623004400 N-terminal domain interface [polypeptide binding]; other site 272623004401 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272623004402 hypothetical protein; Provisional; Region: PRK00468; cl00794 272623004403 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 272623004404 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272623004405 homodimer interface [polypeptide binding]; other site 272623004406 NAD binding site [chemical binding]; other site 272623004407 catalytic residues [active] 272623004408 substrate binding pocket [chemical binding]; other site 272623004409 flexible flap; other site 272623004410 putative acyltransferase; Provisional; Region: PRK05790 272623004411 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272623004412 dimer interface [polypeptide binding]; other site 272623004413 active site 272623004414 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 272623004415 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 272623004416 dimer interface [polypeptide binding]; other site 272623004417 active site 272623004418 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272623004419 active site 272623004420 trimer interface [polypeptide binding]; other site 272623004421 allosteric site; other site 272623004422 active site lid [active] 272623004423 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272623004424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623004425 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272623004426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623004427 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272623004428 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 272623004429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004430 non-specific DNA binding site [nucleotide binding]; other site 272623004431 salt bridge; other site 272623004432 sequence-specific DNA binding site [nucleotide binding]; other site 272623004433 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623004434 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272623004435 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272623004436 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004437 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004438 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004439 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272623004440 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272623004441 GTP1/OBG; Region: GTP1_OBG; pfam01018 272623004442 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 272623004443 G1 box; other site 272623004444 GTP/Mg2+ binding site [chemical binding]; other site 272623004445 Switch I region; other site 272623004446 G2 box; other site 272623004447 G3 box; other site 272623004448 Switch II region; other site 272623004449 G4 box; other site 272623004450 G5 box; other site 272623004451 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 272623004452 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272623004453 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272623004454 Cell division protein FtsQ; Region: FtsQ; pfam03799 272623004455 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272623004456 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272623004457 homodimer interface [polypeptide binding]; other site 272623004458 active site 272623004459 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272623004460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272623004462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623004463 Nitrogen regulatory protein P-II; Region: P-II; cl00412 272623004464 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 272623004465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272623004466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623004467 dimer interface [polypeptide binding]; other site 272623004468 phosphorylation site [posttranslational modification] 272623004469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004470 ATP binding site [chemical binding]; other site 272623004471 Mg2+ binding site [ion binding]; other site 272623004472 G-X-G motif; other site 272623004473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004475 active site 272623004476 phosphorylation site [posttranslational modification] 272623004477 intermolecular recognition site; other site 272623004478 dimerization interface [polypeptide binding]; other site 272623004479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004480 DNA binding site [nucleotide binding] 272623004481 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 272623004482 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 272623004483 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 272623004484 Surface antigen [General function prediction only]; Region: COG3942 272623004485 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 272623004486 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272623004487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272623004488 putative active site [active] 272623004489 putative metal binding site [ion binding]; other site 272623004490 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272623004491 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 272623004492 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272623004493 catalytic site [active] 272623004494 subunit interface [polypeptide binding]; other site 272623004495 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272623004496 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623004497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004498 Permease family; Region: Xan_ur_permease; cl00967 272623004499 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623004500 active site 272623004501 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 272623004502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004503 dimerization interface [polypeptide binding]; other site 272623004504 putative DNA binding site [nucleotide binding]; other site 272623004505 putative Zn2+ binding site [ion binding]; other site 272623004506 Cation efflux family; Region: Cation_efflux; cl00316 272623004507 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272623004508 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272623004509 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272623004510 putative catalytic cysteine [active] 272623004511 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272623004512 nucleotide binding site [chemical binding]; other site 272623004513 homotetrameric interface [polypeptide binding]; other site 272623004514 putative phosphate binding site [ion binding]; other site 272623004515 putative allosteric binding site; other site 272623004516 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272623004517 Family of unknown function (DUF438); Region: DUF438; pfam04282 272623004518 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 272623004519 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 272623004520 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 272623004521 AzlC protein; Region: AzlC; cl00570 272623004522 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 272623004523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004524 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 272623004525 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623004526 signal recognition particle protein; Provisional; Region: PRK10867 272623004527 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 272623004528 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272623004529 P loop; other site 272623004530 GTP binding site [chemical binding]; other site 272623004531 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272623004532 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272623004533 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272623004534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623004535 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272623004536 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272623004537 MgtC family; Region: MgtC; cl12207 272623004538 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272623004539 dihydrodipicolinate synthase; Region: dapA; TIGR00674 272623004540 dimer interface [polypeptide binding]; other site 272623004541 active site 272623004542 catalytic residue [active] 272623004543 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 272623004544 nudix motif; other site 272623004545 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272623004546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004547 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 272623004548 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623004549 amphipathic channel; other site 272623004550 Asn-Pro-Ala signature motifs; other site 272623004551 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272623004552 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272623004553 TPP-binding site [chemical binding]; other site 272623004554 dimer interface [polypeptide binding]; other site 272623004555 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004556 PYR/PP interface [polypeptide binding]; other site 272623004557 dimer interface [polypeptide binding]; other site 272623004558 TPP binding site [chemical binding]; other site 272623004559 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004560 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272623004561 active site 272623004562 intersubunit interface [polypeptide binding]; other site 272623004563 catalytic residue [active] 272623004564 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272623004565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272623004566 substrate binding site [chemical binding]; other site 272623004567 ATP binding site [chemical binding]; other site 272623004568 Glucuronate isomerase; Region: UxaC; cl00829 272623004569 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 272623004570 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272623004571 active site 272623004572 catalytic residues [active] 272623004573 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272623004574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004575 putative substrate translocation pore; other site 272623004576 mannonate dehydratase; Provisional; Region: PRK03906 272623004577 mannonate dehydratase; Region: uxuA; TIGR00695 272623004578 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272623004579 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272623004580 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272623004581 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272623004582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272623004583 DNA-binding site [nucleotide binding]; DNA binding site 272623004584 FCD domain; Region: FCD; cl11656 272623004585 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623004586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623004587 putative substrate translocation pore; other site 272623004588 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272623004589 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272623004590 ligand binding site [chemical binding]; other site 272623004591 dimerization interface [polypeptide binding]; other site 272623004592 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272623004593 TM-ABC transporter signature motif; other site 272623004594 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272623004595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623004596 Walker A/P-loop; other site 272623004597 ATP binding site [chemical binding]; other site 272623004598 Q-loop/lid; other site 272623004599 ABC transporter signature motif; other site 272623004600 Walker B; other site 272623004601 D-loop; other site 272623004602 H-loop/switch region; other site 272623004603 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 272623004604 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 272623004605 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272623004606 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272623004607 substrate binding site [chemical binding]; other site 272623004608 dimer interface [polypeptide binding]; other site 272623004609 ATP binding site [chemical binding]; other site 272623004610 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004612 DNA binding site [nucleotide binding] 272623004613 domain linker motif; other site 272623004614 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272623004615 dimerization interface [polypeptide binding]; other site 272623004616 ligand binding site [chemical binding]; other site 272623004617 adenylosuccinate lyase; Provisional; Region: PRK07492 272623004618 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272623004619 tetramer interface [polypeptide binding]; other site 272623004620 active site 272623004621 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272623004622 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 272623004623 active site 272623004624 catalytic residue [active] 272623004625 dimer interface [polypeptide binding]; other site 272623004626 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 272623004627 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272623004628 catalytic residues [active] 272623004629 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272623004630 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 272623004631 Walker A/P-loop; other site 272623004632 ATP binding site [chemical binding]; other site 272623004633 Q-loop/lid; other site 272623004634 ABC transporter signature motif; other site 272623004635 Walker B; other site 272623004636 D-loop; other site 272623004637 H-loop/switch region; other site 272623004638 Smr domain; Region: Smr; cl02619 272623004639 Colicin V production protein; Region: Colicin_V; cl00567 272623004640 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272623004641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623004643 catabolite control protein A; Region: ccpA; TIGR01481 272623004644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004645 DNA binding site [nucleotide binding] 272623004646 domain linker motif; other site 272623004647 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272623004648 dimerization interface [polypeptide binding]; other site 272623004649 effector binding site; other site 272623004650 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272623004651 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272623004652 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272623004653 active site 272623004654 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 272623004655 THO complex subunit HPR1; Region: HRP1; pfam09433 272623004656 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272623004657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623004658 cell division protein GpsB; Provisional; Region: PRK14127 272623004659 DivIVA domain; Region: DivI1A_domain; TIGR03544 272623004660 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272623004661 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272623004662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623004663 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 272623004664 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272623004665 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623004666 motif II; other site 272623004667 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 272623004668 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272623004669 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 272623004670 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272623004671 ATP-binding site [chemical binding]; other site 272623004672 Sugar specificity; other site 272623004673 Pyrimidine base specificity; other site 272623004674 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272623004675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004676 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 272623004677 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272623004678 UbiA prenyltransferase family; Region: UbiA; cl00337 272623004679 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272623004680 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 272623004681 Cl- selectivity filter; other site 272623004682 Cl- binding residues [ion binding]; other site 272623004683 pore gating glutamate residue; other site 272623004684 dimer interface [polypeptide binding]; other site 272623004685 H+/Cl- coupling transport residue; other site 272623004686 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 272623004687 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623004689 non-specific DNA binding site [nucleotide binding]; other site 272623004690 salt bridge; other site 272623004691 sequence-specific DNA binding site [nucleotide binding]; other site 272623004692 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623004693 Predicted membrane protein [Function unknown]; Region: COG1511 272623004694 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272623004695 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623004696 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272623004697 Haemolytic domain; Region: Haemolytic; cl00506 272623004698 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272623004699 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272623004700 TPP-binding site; other site 272623004701 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272623004702 PYR/PP interface [polypeptide binding]; other site 272623004703 dimer interface [polypeptide binding]; other site 272623004704 TPP binding site [chemical binding]; other site 272623004705 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272623004706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272623004707 dimer interface [polypeptide binding]; other site 272623004708 phosphorylation site [posttranslational modification] 272623004709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004710 ATP binding site [chemical binding]; other site 272623004711 Mg2+ binding site [ion binding]; other site 272623004712 G-X-G motif; other site 272623004713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004715 active site 272623004716 phosphorylation site [posttranslational modification] 272623004717 intermolecular recognition site; other site 272623004718 dimerization interface [polypeptide binding]; other site 272623004719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004720 DNA binding site [nucleotide binding] 272623004721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272623004722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623004723 DNA binding site [nucleotide binding] 272623004724 domain linker motif; other site 272623004725 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272623004726 putative dimerization interface [polypeptide binding]; other site 272623004727 putative ligand binding site [chemical binding]; other site 272623004728 maltose phosphorylase; Provisional; Region: PRK13807 272623004729 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272623004730 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272623004731 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272623004732 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004733 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004734 Ca binding site [ion binding]; other site 272623004735 active site 272623004736 catalytic site [active] 272623004737 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 272623004738 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004739 Ca binding site [ion binding]; other site 272623004740 active site 272623004741 catalytic site [active] 272623004742 maltose O-acetyltransferase; Provisional; Region: PRK10092 272623004743 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623004744 active site 272623004745 substrate binding site [chemical binding]; other site 272623004746 trimer interface [polypeptide binding]; other site 272623004747 CoA binding site [chemical binding]; other site 272623004748 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272623004749 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272623004750 Ca binding site [ion binding]; other site 272623004751 active site 272623004752 catalytic site [active] 272623004753 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272623004754 homodimer interface [polypeptide binding]; other site 272623004755 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272623004756 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272623004757 active site 272623004758 homodimer interface [polypeptide binding]; other site 272623004759 catalytic site [active] 272623004760 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272623004761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623004762 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272623004763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004764 dimer interface [polypeptide binding]; other site 272623004765 conserved gate region; other site 272623004766 putative PBP binding loops; other site 272623004767 ABC-ATPase subunit interface; other site 272623004768 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 272623004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004770 dimer interface [polypeptide binding]; other site 272623004771 conserved gate region; other site 272623004772 putative PBP binding loops; other site 272623004773 ABC-ATPase subunit interface; other site 272623004774 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 272623004775 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272623004776 LssY C-terminus; Region: LssY_C; pfam14067 272623004777 putative transposase OrfB; Reviewed; Region: PHA02517 272623004778 Integrase core domain; Region: rve; cl01316 272623004779 Helix-turn-helix domains; Region: HTH; cl00088 272623004780 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623004781 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623004782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623004783 dimerization interface [polypeptide binding]; other site 272623004784 putative DNA binding site [nucleotide binding]; other site 272623004785 putative Zn2+ binding site [ion binding]; other site 272623004786 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 272623004787 putative active site [active] 272623004788 putative FMN binding site [chemical binding]; other site 272623004789 putative substrate binding site [chemical binding]; other site 272623004790 putative catalytic residue [active] 272623004791 carbamate kinase; Reviewed; Region: PRK12686 272623004792 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623004793 putative substrate binding site [chemical binding]; other site 272623004794 nucleotide binding site [chemical binding]; other site 272623004795 nucleotide binding site [chemical binding]; other site 272623004796 homodimer interface [polypeptide binding]; other site 272623004797 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 272623004798 agmatine deiminase; Region: agmatine_aguA; TIGR03380 272623004799 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623004800 Integrase core domain; Region: rve; cl01316 272623004801 Amino acid permease; Region: AA_permease; cl00524 272623004802 putrescine carbamoyltransferase; Provisional; Region: PRK02255 272623004803 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623004804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272623004806 DNA binding residues [nucleotide binding] 272623004807 dimerization interface [polypeptide binding]; other site 272623004808 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272623004809 cytidylate kinase; Provisional; Region: cmk; PRK00023 272623004810 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272623004811 CMP-binding site; other site 272623004812 The sites determining sugar specificity; other site 272623004813 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 272623004814 putative peptidoglycan binding site; other site 272623004815 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272623004816 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 272623004817 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272623004818 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272623004819 active pocket/dimerization site; other site 272623004820 active site 272623004821 phosphorylation site [posttranslational modification] 272623004822 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272623004823 active site 272623004824 phosphorylation site [posttranslational modification] 272623004825 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 272623004826 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 272623004827 Domain of unknown function (DUF956); Region: DUF956; cl01917 272623004828 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623004829 Domain of unknown function (DUF956); Region: DUF956; cl01917 272623004830 seryl-tRNA synthetase; Provisional; Region: PRK05431 272623004831 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272623004832 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 272623004833 dimer interface [polypeptide binding]; other site 272623004834 active site 272623004835 motif 1; other site 272623004836 motif 2; other site 272623004837 motif 3; other site 272623004838 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272623004839 putative dimer interface [polypeptide binding]; other site 272623004840 catalytic triad [active] 272623004841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623004842 catalytic core [active] 272623004843 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272623004844 PhoU domain; Region: PhoU; pfam01895 272623004845 PhoU domain; Region: PhoU; pfam01895 272623004846 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 272623004847 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 272623004848 Walker A/P-loop; other site 272623004849 ATP binding site [chemical binding]; other site 272623004850 Q-loop/lid; other site 272623004851 ABC transporter signature motif; other site 272623004852 Walker B; other site 272623004853 D-loop; other site 272623004854 H-loop/switch region; other site 272623004855 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 272623004856 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 272623004857 Walker A/P-loop; other site 272623004858 ATP binding site [chemical binding]; other site 272623004859 Q-loop/lid; other site 272623004860 ABC transporter signature motif; other site 272623004861 Walker B; other site 272623004862 D-loop; other site 272623004863 H-loop/switch region; other site 272623004864 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272623004865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004866 dimer interface [polypeptide binding]; other site 272623004867 conserved gate region; other site 272623004868 putative PBP binding loops; other site 272623004869 ABC-ATPase subunit interface; other site 272623004870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623004871 dimer interface [polypeptide binding]; other site 272623004872 conserved gate region; other site 272623004873 putative PBP binding loops; other site 272623004874 ABC-ATPase subunit interface; other site 272623004875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623004876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272623004877 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272623004878 SmpB-tmRNA interface; other site 272623004879 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 272623004880 catalytic triad [active] 272623004881 oxyanion hole [active] 272623004882 active site 272623004883 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272623004884 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 272623004885 motif 1; other site 272623004886 active site 272623004887 motif 2; other site 272623004888 motif 3; other site 272623004889 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272623004890 DHHA1 domain; Region: DHHA1; pfam02272 272623004891 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 272623004892 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272623004893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623004894 S-adenosylmethionine binding site [chemical binding]; other site 272623004895 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272623004896 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272623004897 active site 272623004898 Zn binding site [ion binding]; other site 272623004899 Competence protein CoiA-like family; Region: CoiA; cl11541 272623004900 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272623004901 putative active site [active] 272623004902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623004903 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272623004904 Sulfate transporter family; Region: Sulfate_transp; cl15842 272623004905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004906 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272623004907 active site 272623004908 motif I; other site 272623004909 motif II; other site 272623004910 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623004911 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272623004912 Cysteine-rich domain; Region: CCG; pfam02754 272623004913 Cysteine-rich domain; Region: CCG; pfam02754 272623004914 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 272623004915 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 272623004916 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 272623004917 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272623004918 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272623004919 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 272623004920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623004921 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 272623004922 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272623004923 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272623004924 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623004925 catalytic core [active] 272623004926 prephenate dehydratase; Provisional; Region: PRK11898 272623004927 Prephenate dehydratase; Region: PDT; pfam00800 272623004928 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272623004929 putative L-Phe binding site [chemical binding]; other site 272623004930 shikimate kinase; Reviewed; Region: aroK; PRK00131 272623004931 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272623004932 ADP binding site [chemical binding]; other site 272623004933 magnesium binding site [ion binding]; other site 272623004934 putative shikimate binding site; other site 272623004935 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272623004936 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 272623004937 hinge; other site 272623004938 active site 272623004939 prephenate dehydrogenase; Validated; Region: PRK06545 272623004940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623004941 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 272623004942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272623004943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623004944 ATP binding site [chemical binding]; other site 272623004945 Mg2+ binding site [ion binding]; other site 272623004946 G-X-G motif; other site 272623004947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272623004948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272623004949 active site 272623004950 phosphorylation site [posttranslational modification] 272623004951 intermolecular recognition site; other site 272623004952 dimerization interface [polypeptide binding]; other site 272623004953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272623004954 DNA binding site [nucleotide binding] 272623004955 VanZ like family; Region: VanZ; cl01971 272623004956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623004957 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623004958 Walker A/P-loop; other site 272623004959 ATP binding site [chemical binding]; other site 272623004960 Q-loop/lid; other site 272623004961 ABC transporter signature motif; other site 272623004962 Walker B; other site 272623004963 D-loop; other site 272623004964 H-loop/switch region; other site 272623004965 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 272623004966 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272623004967 Tetramer interface [polypeptide binding]; other site 272623004968 active site 272623004969 FMN-binding site [chemical binding]; other site 272623004970 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272623004971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623004972 active site 272623004973 motif I; other site 272623004974 motif II; other site 272623004975 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 272623004976 Protein of unknown function, DUF606; Region: DUF606; cl01273 272623004977 Protein of unknown function, DUF606; Region: DUF606; cl01273 272623004978 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272623004979 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272623004980 active site 272623004981 dimer interface [polypeptide binding]; other site 272623004982 metal binding site [ion binding]; metal-binding site 272623004983 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272623004984 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272623004985 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272623004986 shikimate binding site; other site 272623004987 NAD(P) binding site [chemical binding]; other site 272623004988 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272623004989 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272623004990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623004991 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623004992 substrate binding pocket [chemical binding]; other site 272623004993 membrane-bound complex binding site; other site 272623004994 hinge residues; other site 272623004995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623004996 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623004997 substrate binding pocket [chemical binding]; other site 272623004998 membrane-bound complex binding site; other site 272623004999 hinge residues; other site 272623005000 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272623005001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005002 dimer interface [polypeptide binding]; other site 272623005003 conserved gate region; other site 272623005004 putative PBP binding loops; other site 272623005005 ABC-ATPase subunit interface; other site 272623005006 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623005007 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 272623005008 Walker A/P-loop; other site 272623005009 ATP binding site [chemical binding]; other site 272623005010 Q-loop/lid; other site 272623005011 ABC transporter signature motif; other site 272623005012 Walker B; other site 272623005013 D-loop; other site 272623005014 H-loop/switch region; other site 272623005015 legume lectins; Region: lectin_L-type; cl14058 272623005016 homotetramer interaction site [polypeptide binding]; other site 272623005017 carbohydrate binding site [chemical binding]; other site 272623005018 metal binding site [ion binding]; metal-binding site 272623005019 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272623005020 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 272623005021 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272623005022 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 272623005023 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272623005024 alpha subunit interaction interface [polypeptide binding]; other site 272623005025 Walker A motif; other site 272623005026 ATP binding site [chemical binding]; other site 272623005027 Walker B motif; other site 272623005028 inhibitor binding site; inhibition site 272623005029 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272623005030 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 272623005031 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 272623005032 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272623005033 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 272623005034 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272623005035 beta subunit interaction interface [polypeptide binding]; other site 272623005036 Walker A motif; other site 272623005037 ATP binding site [chemical binding]; other site 272623005038 Walker B motif; other site 272623005039 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272623005040 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 272623005041 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272623005042 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272623005043 Plant ATP synthase F0; Region: YMF19; cl07975 272623005044 ATP synthase A chain; Region: ATP-synt_A; cl00413 272623005045 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272623005046 Predicted esterase [General function prediction only]; Region: COG0627 272623005047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623005048 Competence protein; Region: Competence; cl00471 272623005049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272623005050 SLBB domain; Region: SLBB; pfam10531 272623005051 comEA protein; Region: comE; TIGR01259 272623005052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272623005053 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272623005054 ABC-2 type transporter; Region: ABC2_membrane; cl11417 272623005055 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272623005056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005057 Walker A/P-loop; other site 272623005058 ATP binding site [chemical binding]; other site 272623005059 Q-loop/lid; other site 272623005060 ABC transporter signature motif; other site 272623005061 Walker B; other site 272623005062 D-loop; other site 272623005063 H-loop/switch region; other site 272623005064 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272623005065 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623005066 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 272623005067 transmembrane helices; other site 272623005068 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 272623005069 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 272623005070 CHY zinc finger; Region: zf-CHY; pfam05495 272623005071 Helix-turn-helix domains; Region: HTH; cl00088 272623005072 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 272623005073 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272623005074 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272623005075 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 272623005076 AMP-binding enzyme; Region: AMP-binding; cl15778 272623005077 acyl-CoA synthetase; Validated; Region: PRK07470 272623005078 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 272623005079 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272623005080 dimer interface [polypeptide binding]; other site 272623005081 active site 272623005082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272623005083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005084 NAD(P) binding site [chemical binding]; other site 272623005085 active site 272623005086 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272623005087 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272623005088 FMN binding site [chemical binding]; other site 272623005089 substrate binding site [chemical binding]; other site 272623005090 putative catalytic residue [active] 272623005091 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 272623005092 FeS assembly protein SufB; Region: sufB; TIGR01980 272623005093 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272623005094 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272623005095 trimerization site [polypeptide binding]; other site 272623005096 active site 272623005097 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272623005098 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272623005099 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272623005100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623005101 catalytic residue [active] 272623005102 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272623005103 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 272623005104 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272623005105 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272623005106 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272623005107 Mg++ binding site [ion binding]; other site 272623005108 putative catalytic motif [active] 272623005109 substrate binding site [chemical binding]; other site 272623005110 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 272623005111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272623005112 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 272623005113 Walker A/P-loop; other site 272623005114 ATP binding site [chemical binding]; other site 272623005115 Q-loop/lid; other site 272623005116 ABC transporter signature motif; other site 272623005117 Walker B; other site 272623005118 D-loop; other site 272623005119 H-loop/switch region; other site 272623005120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272623005121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005122 dimer interface [polypeptide binding]; other site 272623005123 conserved gate region; other site 272623005124 putative PBP binding loops; other site 272623005125 ABC-ATPase subunit interface; other site 272623005126 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272623005127 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 272623005128 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272623005129 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272623005130 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 272623005131 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272623005132 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272623005133 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272623005134 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272623005135 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272623005136 G-loop; other site 272623005137 DNA binding site [nucleotide binding] 272623005138 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272623005139 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 272623005140 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272623005141 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272623005142 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272623005143 RPB1 interaction site [polypeptide binding]; other site 272623005144 RPB10 interaction site [polypeptide binding]; other site 272623005145 RPB11 interaction site [polypeptide binding]; other site 272623005146 RPB3 interaction site [polypeptide binding]; other site 272623005147 RPB12 interaction site [polypeptide binding]; other site 272623005148 CodY GAF-like domain; Region: CodY; pfam06018 272623005149 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272623005150 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272623005151 active site 272623005152 Zn binding site [ion binding]; other site 272623005153 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272623005154 active site 272623005155 DNA binding site [nucleotide binding] 272623005156 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272623005157 MatE; Region: MatE; cl10513 272623005158 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 272623005159 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623005160 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 272623005161 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623005162 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 272623005163 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 272623005164 NAD binding site [chemical binding]; other site 272623005165 substrate binding site [chemical binding]; other site 272623005166 catalytic Zn binding site [ion binding]; other site 272623005167 tetramer interface [polypeptide binding]; other site 272623005168 structural Zn binding site [ion binding]; other site 272623005169 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272623005170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623005171 ATP binding site [chemical binding]; other site 272623005172 putative Mg++ binding site [ion binding]; other site 272623005173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623005174 nucleotide binding region [chemical binding]; other site 272623005175 ATP-binding site [chemical binding]; other site 272623005176 RQC domain; Region: RQC; cl09632 272623005177 HRDC domain; Region: HRDC; cl02578 272623005178 inner membrane transporter YjeM; Provisional; Region: PRK15238 272623005179 peptidase T; Region: peptidase-T; TIGR01882 272623005180 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272623005181 metal binding site [ion binding]; metal-binding site 272623005182 dimer interface [polypeptide binding]; other site 272623005183 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272623005184 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 272623005185 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272623005186 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272623005187 DHHA2 domain; Region: DHHA2; pfam02833 272623005188 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 272623005189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623005190 FeS/SAM binding site; other site 272623005191 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272623005192 Domain of unknown function DUF21; Region: DUF21; pfam01595 272623005193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272623005194 Transporter associated domain; Region: CorC_HlyC; cl08393 272623005195 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272623005196 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 272623005197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005198 Coenzyme A binding pocket [chemical binding]; other site 272623005199 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272623005200 putative uracil binding site [chemical binding]; other site 272623005201 putative active site [active] 272623005202 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272623005203 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 272623005204 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 272623005205 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 272623005206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272623005207 catalytic core [active] 272623005208 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272623005209 GIY-YIG motif/motif A; other site 272623005210 putative active site [active] 272623005211 putative metal binding site [ion binding]; other site 272623005212 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272623005213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005214 Thiamine pyrophosphokinase; Region: TPK; cd07995 272623005215 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 272623005216 active site 272623005217 dimerization interface [polypeptide binding]; other site 272623005218 thiamine binding site [chemical binding]; other site 272623005219 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 272623005220 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272623005221 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272623005222 putative dimer interface [polypeptide binding]; other site 272623005223 putative anticodon binding site; other site 272623005224 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272623005225 homodimer interface [polypeptide binding]; other site 272623005226 motif 1; other site 272623005227 motif 2; other site 272623005228 active site 272623005229 motif 3; other site 272623005230 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 272623005231 GIY-YIG motif/motif A; other site 272623005232 aspartate aminotransferase; Provisional; Region: PRK05764 272623005233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623005234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005235 homodimer interface [polypeptide binding]; other site 272623005236 catalytic residue [active] 272623005237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272623005238 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 272623005239 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623005240 active site 272623005241 substrate binding site [chemical binding]; other site 272623005242 catalytic site [active] 272623005243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005245 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623005246 Ligand Binding Site [chemical binding]; other site 272623005247 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272623005248 Domain of unknown function DUF21; Region: DUF21; pfam01595 272623005249 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272623005250 Transporter associated domain; Region: CorC_HlyC; cl08393 272623005251 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272623005252 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272623005253 active site 272623005254 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272623005255 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 272623005256 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272623005257 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272623005258 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272623005259 peptide binding site [polypeptide binding]; other site 272623005260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272623005261 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272623005262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005263 dimer interface [polypeptide binding]; other site 272623005264 conserved gate region; other site 272623005265 putative PBP binding loops; other site 272623005266 ABC-ATPase subunit interface; other site 272623005267 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272623005268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272623005269 dimer interface [polypeptide binding]; other site 272623005270 conserved gate region; other site 272623005271 putative PBP binding loops; other site 272623005272 ABC-ATPase subunit interface; other site 272623005273 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272623005274 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272623005275 Walker A/P-loop; other site 272623005276 ATP binding site [chemical binding]; other site 272623005277 Q-loop/lid; other site 272623005278 ABC transporter signature motif; other site 272623005279 Walker B; other site 272623005280 D-loop; other site 272623005281 H-loop/switch region; other site 272623005282 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272623005283 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272623005284 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 272623005285 Walker A/P-loop; other site 272623005286 ATP binding site [chemical binding]; other site 272623005287 Q-loop/lid; other site 272623005288 ABC transporter signature motif; other site 272623005289 Walker B; other site 272623005290 D-loop; other site 272623005291 H-loop/switch region; other site 272623005292 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272623005293 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272623005294 23S rRNA binding site [nucleotide binding]; other site 272623005295 L21 binding site [polypeptide binding]; other site 272623005296 L13 binding site [polypeptide binding]; other site 272623005297 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 272623005298 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272623005299 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272623005300 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272623005301 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272623005302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623005303 motif II; other site 272623005304 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272623005305 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 272623005306 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 272623005307 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272623005308 active site 272623005309 metal binding site [ion binding]; metal-binding site 272623005310 dimerization interface [polypeptide binding]; other site 272623005311 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272623005312 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272623005313 active site 272623005314 HIGH motif; other site 272623005315 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272623005316 KMSKS motif; other site 272623005317 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272623005318 tRNA binding surface [nucleotide binding]; other site 272623005319 anticodon binding site; other site 272623005320 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272623005321 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272623005322 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272623005323 trimer interface [polypeptide binding]; other site 272623005324 active site 272623005325 substrate binding site [chemical binding]; other site 272623005326 CoA binding site [chemical binding]; other site 272623005327 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272623005328 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 272623005329 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 272623005330 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272623005331 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 272623005332 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 272623005333 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272623005334 putative nucleic acid binding region [nucleotide binding]; other site 272623005335 G-X-X-G motif; other site 272623005336 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272623005337 RNA binding site [nucleotide binding]; other site 272623005338 domain interface; other site 272623005339 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 272623005340 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272623005341 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623005342 active site 272623005343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623005344 Ligand Binding Site [chemical binding]; other site 272623005345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272623005346 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 272623005347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272623005348 catalytic residue [active] 272623005349 Putative amino acid metabolism; Region: DUF1831; pfam08866 272623005350 elongation factor Tu; Reviewed; Region: PRK00049 272623005351 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 272623005352 G1 box; other site 272623005353 GEF interaction site [polypeptide binding]; other site 272623005354 GTP/Mg2+ binding site [chemical binding]; other site 272623005355 Switch I region; other site 272623005356 G2 box; other site 272623005357 G3 box; other site 272623005358 Switch II region; other site 272623005359 G4 box; other site 272623005360 G5 box; other site 272623005361 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272623005362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272623005363 Antibiotic Binding Site [chemical binding]; other site 272623005364 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272623005365 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623005366 active site 272623005367 HIGH motif; other site 272623005368 nucleotide binding site [chemical binding]; other site 272623005369 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272623005370 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272623005371 active site 272623005372 KMSKS motif; other site 272623005373 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272623005374 tRNA binding surface [nucleotide binding]; other site 272623005375 anticodon binding site; other site 272623005376 DivIVA protein; Region: DivIVA; pfam05103 272623005377 DivIVA domain; Region: DivI1A_domain; TIGR03544 272623005378 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 272623005379 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272623005380 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272623005381 YGGT family; Region: YGGT; cl00508 272623005382 Protein of unknown function (DUF552); Region: DUF552; cl00775 272623005383 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272623005384 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272623005385 catalytic residue [active] 272623005386 cell division protein FtsZ; Validated; Region: PRK09330 272623005387 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272623005388 nucleotide binding site [chemical binding]; other site 272623005389 SulA interaction site; other site 272623005390 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272623005391 Cell division protein FtsA; Region: FtsA; cl11496 272623005392 Cell division protein FtsA; Region: FtsA; cl11496 272623005393 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 272623005394 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 272623005395 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272623005396 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 272623005397 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 272623005398 FAD dependent oxidoreductase; Region: DAO; pfam01266 272623005399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623005400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272623005401 active site 272623005402 catalytic tetrad [active] 272623005403 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272623005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 272623005405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272623005406 Helix-turn-helix domains; Region: HTH; cl00088 272623005407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272623005408 dimerization interface [polypeptide binding]; other site 272623005409 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623005410 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623005411 DNA binding residues [nucleotide binding] 272623005412 putative dimer interface [polypeptide binding]; other site 272623005413 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272623005414 trimer interface [polypeptide binding]; other site 272623005415 active site 272623005416 G bulge; other site 272623005417 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 272623005418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272623005419 Zn2+ binding site [ion binding]; other site 272623005420 Mg2+ binding site [ion binding]; other site 272623005421 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272623005422 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272623005423 dimer interface [polypeptide binding]; other site 272623005424 ADP-ribose binding site [chemical binding]; other site 272623005425 active site 272623005426 nudix motif; other site 272623005427 metal binding site [ion binding]; metal-binding site 272623005428 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272623005429 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272623005430 Substrate binding site; other site 272623005431 Mg++ binding site; other site 272623005432 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272623005433 active site 272623005434 substrate binding site [chemical binding]; other site 272623005435 CoA binding site [chemical binding]; other site 272623005436 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272623005437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005438 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005439 Integrase core domain; Region: rve; cl01316 272623005440 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272623005441 16S/18S rRNA binding site [nucleotide binding]; other site 272623005442 S13e-L30e interaction site [polypeptide binding]; other site 272623005443 25S rRNA binding site [nucleotide binding]; other site 272623005444 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272623005445 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272623005446 active site 272623005447 ATP binding site [chemical binding]; other site 272623005448 substrate binding site [chemical binding]; other site 272623005449 activation loop (A-loop); other site 272623005450 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005451 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005452 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272623005453 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272623005454 active site 272623005455 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272623005456 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 272623005457 putative RNA binding site [nucleotide binding]; other site 272623005458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 272623005459 Protein of unknown function (DUF322); Region: DUF322; cl00574 272623005460 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 272623005461 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272623005462 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272623005463 putative active site [active] 272623005464 substrate binding site [chemical binding]; other site 272623005465 putative cosubstrate binding site; other site 272623005466 catalytic site [active] 272623005467 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272623005468 substrate binding site [chemical binding]; other site 272623005469 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272623005470 dimer interface [polypeptide binding]; other site 272623005471 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272623005472 nudix motif; other site 272623005473 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272623005474 primosome assembly protein PriA; Validated; Region: PRK05580 272623005475 primosome assembly protein PriA; Validated; Region: PRK05580 272623005476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623005477 ATP binding site [chemical binding]; other site 272623005478 putative Mg++ binding site [ion binding]; other site 272623005479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623005480 nucleotide binding region [chemical binding]; other site 272623005481 ATP-binding site [chemical binding]; other site 272623005482 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 272623005483 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272623005484 catalytic site [active] 272623005485 G-X2-G-X-G-K; other site 272623005486 phosphodiesterase; Provisional; Region: PRK12704 272623005487 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 272623005488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623005489 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272623005490 active site 272623005491 trimer interface [polypeptide binding]; other site 272623005492 allosteric site; other site 272623005493 active site lid [active] 272623005494 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272623005495 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272623005496 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272623005497 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272623005498 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272623005499 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272623005500 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272623005501 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272623005502 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272623005503 PspC domain; Region: PspC; cl00864 272623005504 PspC domain; Region: PspC; cl00864 272623005505 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272623005506 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 272623005507 NlpC/P60 family; Region: NLPC_P60; cl11438 272623005508 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005509 Integrase core domain; Region: rve; cl01316 272623005510 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272623005511 hypothetical protein; Provisional; Region: PRK08185 272623005512 intersubunit interface [polypeptide binding]; other site 272623005513 active site 272623005514 zinc binding site [ion binding]; other site 272623005515 Na+ binding site [ion binding]; other site 272623005516 Predicted membrane protein [Function unknown]; Region: COG2860 272623005517 UPF0126 domain; Region: UPF0126; pfam03458 272623005518 UPF0126 domain; Region: UPF0126; pfam03458 272623005519 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272623005520 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272623005521 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272623005522 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272623005523 active site 272623005524 dimer interface [polypeptide binding]; other site 272623005525 motif 1; other site 272623005526 motif 2; other site 272623005527 motif 3; other site 272623005528 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272623005529 anticodon binding site; other site 272623005530 ATP cone domain; Region: ATP-cone; pfam03477 272623005531 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 272623005532 dimer interface [polypeptide binding]; other site 272623005533 FMN binding site [chemical binding]; other site 272623005534 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 272623005535 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272623005536 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272623005537 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 272623005538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623005539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005540 homodimer interface [polypeptide binding]; other site 272623005541 catalytic residue [active] 272623005542 cystathionine gamma-synthase; Reviewed; Region: PRK07269 272623005543 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272623005544 homodimer interface [polypeptide binding]; other site 272623005545 substrate-cofactor binding pocket; other site 272623005546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005547 catalytic residue [active] 272623005548 Homoserine O-succinyltransferase; Region: HTS; pfam04204 272623005549 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272623005550 proposed active site lysine [active] 272623005551 conserved cys residue [active] 272623005552 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 272623005553 nudix motif; other site 272623005554 Membrane transport protein; Region: Mem_trans; cl09117 272623005555 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272623005556 active site 272623005557 catalytic residues [active] 272623005558 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272623005559 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 272623005560 generic binding surface II; other site 272623005561 generic binding surface I; other site 272623005562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 272623005563 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 272623005564 RmuC family; Region: RmuC; pfam02646 272623005565 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272623005566 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272623005567 substrate binding site [chemical binding]; other site 272623005568 hexamer interface [polypeptide binding]; other site 272623005569 metal binding site [ion binding]; metal-binding site 272623005570 GTPase RsgA; Reviewed; Region: PRK00098 272623005571 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 272623005572 GTPase/OB domain interface [polypeptide binding]; other site 272623005573 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272623005574 GTP/Mg2+ binding site [chemical binding]; other site 272623005575 G4 box; other site 272623005576 G1 box; other site 272623005577 Switch I region; other site 272623005578 G2 box; other site 272623005579 G3 box; other site 272623005580 Switch II region; other site 272623005581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623005582 3D domain; Region: 3D; cl01439 272623005583 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272623005584 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272623005585 putative tRNA-binding site [nucleotide binding]; other site 272623005586 B3/4 domain; Region: B3_4; cl11458 272623005587 tRNA synthetase B5 domain; Region: B5; cl08394 272623005588 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272623005589 dimer interface [polypeptide binding]; other site 272623005590 motif 1; other site 272623005591 motif 3; other site 272623005592 motif 2; other site 272623005593 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 272623005594 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272623005595 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272623005596 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272623005597 dimer interface [polypeptide binding]; other site 272623005598 motif 1; other site 272623005599 active site 272623005600 motif 2; other site 272623005601 motif 3; other site 272623005602 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 272623005603 defective Bacteriophage bIL311; ps3 272623005604 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005605 Integrase core domain; Region: rve; cl01316 272623005606 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 272623005607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623005608 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 272623005609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005610 Coenzyme A binding pocket [chemical binding]; other site 272623005611 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623005612 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005613 Integrase core domain; Region: rve; cl01316 272623005614 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272623005615 Protein of unknown function (DUF1655); Region: DUF1655; pfam07868 272623005616 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272623005617 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 272623005618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623005619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005620 non-specific DNA binding site [nucleotide binding]; other site 272623005621 salt bridge; other site 272623005622 sequence-specific DNA binding site [nucleotide binding]; other site 272623005623 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272623005624 Phage integrase family; Region: Phage_integrase; pfam00589 272623005625 Int/Topo IB signature motif; other site 272623005626 Helix-turn-helix domains; Region: HTH; cl00088 272623005627 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272623005628 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 272623005629 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 272623005630 putative active site [active] 272623005631 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272623005632 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 272623005633 chitin/cellulose binding site [chemical binding]; other site 272623005634 Chitin binding domain; Region: Chitin_bind_3; cl03871 272623005635 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272623005636 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272623005637 GDP-binding site [chemical binding]; other site 272623005638 ACT binding site; other site 272623005639 IMP binding site; other site 272623005640 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 272623005641 Cadmium resistance transporter; Region: Cad; cl04177 272623005642 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272623005643 Protein of unknown function (DUF419); Region: DUF419; cl15265 272623005644 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272623005645 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272623005646 dimerization interface [polypeptide binding]; other site 272623005647 domain crossover interface; other site 272623005648 redox-dependent activation switch; other site 272623005649 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 272623005650 folate binding site [chemical binding]; other site 272623005651 NADP+ binding site [chemical binding]; other site 272623005652 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272623005653 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272623005654 FMN binding site [chemical binding]; other site 272623005655 active site 272623005656 catalytic residues [active] 272623005657 substrate binding site [chemical binding]; other site 272623005658 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623005659 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005660 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005661 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 272623005662 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272623005663 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005664 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005665 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 272623005666 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005667 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272623005668 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 272623005669 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272623005670 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272623005671 dimer interface [polypeptide binding]; other site 272623005672 anticodon binding site; other site 272623005673 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 272623005674 homodimer interface [polypeptide binding]; other site 272623005675 motif 1; other site 272623005676 active site 272623005677 motif 2; other site 272623005678 GAD domain; Region: GAD; pfam02938 272623005679 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272623005680 active site 272623005681 motif 3; other site 272623005682 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272623005683 nucleotide binding site/active site [active] 272623005684 HIT family signature motif; other site 272623005685 catalytic residue [active] 272623005686 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272623005687 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 272623005688 dimer interface [polypeptide binding]; other site 272623005689 motif 1; other site 272623005690 active site 272623005691 motif 2; other site 272623005692 motif 3; other site 272623005693 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272623005694 anticodon binding site; other site 272623005695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623005696 non-specific DNA binding site [nucleotide binding]; other site 272623005697 salt bridge; other site 272623005698 sequence-specific DNA binding site [nucleotide binding]; other site 272623005699 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623005700 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272623005701 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272623005702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 272623005703 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272623005704 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272623005705 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272623005706 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272623005707 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272623005708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 272623005709 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005710 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272623005711 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272623005712 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272623005713 DNA binding residues [nucleotide binding] 272623005714 putative dimer interface [polypeptide binding]; other site 272623005715 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 272623005716 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272623005717 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272623005718 NAD binding site [chemical binding]; other site 272623005719 homodimer interface [polypeptide binding]; other site 272623005720 active site 272623005721 substrate binding site [chemical binding]; other site 272623005722 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 272623005723 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 272623005724 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272623005725 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 272623005726 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 272623005727 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272623005728 trimer interface [polypeptide binding]; other site 272623005729 active site 272623005730 substrate binding site [chemical binding]; other site 272623005731 CoA binding site [chemical binding]; other site 272623005732 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272623005733 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 272623005734 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272623005735 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272623005736 galactokinase; Provisional; Region: PRK05322 272623005737 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272623005738 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272623005739 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 272623005740 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272623005741 active site 272623005742 catalytic residues [active] 272623005743 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623005744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623005745 putative active site [active] 272623005746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272623005747 active site 272623005748 catalytic tetrad [active] 272623005749 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 272623005750 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 272623005751 active site 272623005752 (T/H)XGH motif; other site 272623005753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005754 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272623005755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005756 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272623005757 Peptidase family U32; Region: Peptidase_U32; cl03113 272623005758 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272623005759 Peptidase family U32; Region: Peptidase_U32; cl03113 272623005760 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 272623005761 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 272623005762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623005763 CutC family; Region: CutC; cl01218 272623005764 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 272623005765 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272623005766 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 272623005767 Walker A/P-loop; other site 272623005768 ATP binding site [chemical binding]; other site 272623005769 Q-loop/lid; other site 272623005770 ABC transporter signature motif; other site 272623005771 Walker B; other site 272623005772 D-loop; other site 272623005773 H-loop/switch region; other site 272623005774 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 272623005775 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272623005776 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 272623005777 putative active site [active] 272623005778 catalytic site [active] 272623005779 putative metal binding site [ion binding]; other site 272623005780 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272623005781 HIT family signature motif; other site 272623005782 catalytic residue [active] 272623005783 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272623005784 mRNA/rRNA interface [nucleotide binding]; other site 272623005785 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272623005786 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272623005787 23S rRNA interface [nucleotide binding]; other site 272623005788 L7/L12 interface [polypeptide binding]; other site 272623005789 putative thiostrepton binding site; other site 272623005790 L25 interface [polypeptide binding]; other site 272623005791 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272623005792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623005793 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623005794 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272623005795 ligand binding site [chemical binding]; other site 272623005796 flexible hinge region; other site 272623005797 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272623005798 putative switch regulator; other site 272623005799 non-specific DNA interactions [nucleotide binding]; other site 272623005800 DNA binding site [nucleotide binding] 272623005801 sequence specific DNA binding site [nucleotide binding]; other site 272623005802 putative cAMP binding site [chemical binding]; other site 272623005803 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005804 Helix-turn-helix domains; Region: HTH; cl00088 272623005805 Integrase core domain; Region: rve; cl01316 272623005806 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 272623005807 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 272623005808 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272623005809 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623005810 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272623005811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272623005812 Coenzyme A binding pocket [chemical binding]; other site 272623005813 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272623005814 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 272623005815 hinge region; other site 272623005816 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272623005817 putative nucleotide binding site [chemical binding]; other site 272623005818 uridine monophosphate binding site [chemical binding]; other site 272623005819 homohexameric interface [polypeptide binding]; other site 272623005820 Acetokinase family; Region: Acetate_kinase; cl01029 272623005821 propionate/acetate kinase; Provisional; Region: PRK12379 272623005822 Acetokinase family; Region: Acetate_kinase; cl01029 272623005823 propionate/acetate kinase; Provisional; Region: PRK12379 272623005824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623005825 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272623005826 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272623005827 G1 box; other site 272623005828 putative GEF interaction site [polypeptide binding]; other site 272623005829 GTP/Mg2+ binding site [chemical binding]; other site 272623005830 Switch I region; other site 272623005831 G2 box; other site 272623005832 G3 box; other site 272623005833 Switch II region; other site 272623005834 G4 box; other site 272623005835 G5 box; other site 272623005836 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272623005837 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272623005838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623005839 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272623005840 Walker A/P-loop; other site 272623005841 ATP binding site [chemical binding]; other site 272623005842 Q-loop/lid; other site 272623005843 ABC transporter signature motif; other site 272623005844 Walker B; other site 272623005845 D-loop; other site 272623005846 H-loop/switch region; other site 272623005847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 272623005848 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272623005849 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 272623005850 LytTr DNA-binding domain; Region: LytTR; cl04498 272623005851 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 272623005852 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272623005853 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272623005854 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272623005855 Ferritin-like domain; Region: Ferritin; pfam00210 272623005856 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272623005857 dimerization interface [polypeptide binding]; other site 272623005858 DPS ferroxidase diiron center [ion binding]; other site 272623005859 ion pore; other site 272623005860 putative transposase OrfB; Reviewed; Region: PHA02517 272623005861 Integrase core domain; Region: rve; cl01316 272623005862 Helix-turn-helix domains; Region: HTH; cl00088 272623005863 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272623005864 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272623005865 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272623005866 active site 272623005867 DNA polymerase IV; Validated; Region: PRK02406 272623005868 DNA binding site [nucleotide binding] 272623005869 Uncharacterized conserved protein [Function unknown]; Region: COG3760 272623005870 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 272623005871 putative deacylase active site [active] 272623005872 Amino acid permease; Region: AA_permease; cl00524 272623005873 transaminase; Validated; Region: PRK07324 272623005874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272623005875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623005876 homodimer interface [polypeptide binding]; other site 272623005877 catalytic residue [active] 272623005878 carbamate kinase; Reviewed; Region: PRK12686 272623005879 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623005880 putative substrate binding site [chemical binding]; other site 272623005881 nucleotide binding site [chemical binding]; other site 272623005882 nucleotide binding site [chemical binding]; other site 272623005883 homodimer interface [polypeptide binding]; other site 272623005884 carbamate kinase; Reviewed; Region: PRK12686 272623005885 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272623005886 putative substrate binding site [chemical binding]; other site 272623005887 nucleotide binding site [chemical binding]; other site 272623005888 nucleotide binding site [chemical binding]; other site 272623005889 homodimer interface [polypeptide binding]; other site 272623005890 Amino acid permease; Region: AA_permease; cl00524 272623005891 ornithine carbamoyltransferase; Validated; Region: PRK02102 272623005892 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272623005893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005894 Amidinotransferase; Region: Amidinotransf; cl12043 272623005895 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272623005896 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 272623005897 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272623005898 active site 272623005899 HIGH motif; other site 272623005900 KMSK motif region; other site 272623005901 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272623005902 tRNA binding surface [nucleotide binding]; other site 272623005903 anticodon binding site; other site 272623005904 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272623005905 arginine repressor; Region: argR_whole; TIGR01529 272623005906 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272623005907 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272623005908 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272623005909 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 272623005910 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272623005911 SWIM zinc finger; Region: SWIM; cl15408 272623005912 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272623005913 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272623005914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623005915 ATP binding site [chemical binding]; other site 272623005916 putative Mg++ binding site [ion binding]; other site 272623005917 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272623005918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623005919 nucleotide binding region [chemical binding]; other site 272623005920 ATP-binding site [chemical binding]; other site 272623005921 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 272623005922 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272623005923 metal ion-dependent adhesion site (MIDAS); other site 272623005924 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 272623005925 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 272623005926 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 272623005927 PYR/PP interface [polypeptide binding]; other site 272623005928 tetramer interface [polypeptide binding]; other site 272623005929 dimer interface [polypeptide binding]; other site 272623005930 TPP binding site [chemical binding]; other site 272623005931 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 272623005932 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272623005933 TPP-binding site [chemical binding]; other site 272623005934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623005935 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623005936 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272623005937 amphipathic channel; other site 272623005938 Asn-Pro-Ala signature motifs; other site 272623005939 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 272623005940 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 272623005941 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 272623005942 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272623005943 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272623005944 catalytic triad [active] 272623005945 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272623005946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272623005947 substrate binding pocket [chemical binding]; other site 272623005948 membrane-bound complex binding site; other site 272623005949 hinge residues; other site 272623005950 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 272623005951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623005952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623005953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623005954 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272623005955 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272623005956 active site 272623005957 HIGH motif; other site 272623005958 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272623005959 active site 272623005960 KMSKS motif; other site 272623005961 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272623005962 catalytic triad [active] 272623005963 conserved cis-peptide bond; other site 272623005964 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 272623005965 active site 272623005966 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623005967 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 272623005968 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 272623005969 Helix-turn-helix domains; Region: HTH; cl00088 272623005970 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272623005971 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272623005972 putative active site [active] 272623005973 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623005974 Helix-turn-helix domains; Region: HTH; cl00088 272623005975 Integrase core domain; Region: rve; cl01316 272623005976 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 272623005977 DNA repair protein RadA; Provisional; Region: PRK11823 272623005978 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272623005979 Walker A motif/ATP binding site; other site 272623005980 ATP binding site [chemical binding]; other site 272623005981 Walker B motif; other site 272623005982 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 272623005983 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272623005984 metal-binding site [ion binding] 272623005985 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272623005986 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 272623005987 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272623005988 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272623005989 alphaNTD homodimer interface [polypeptide binding]; other site 272623005990 alphaNTD - beta interaction site [polypeptide binding]; other site 272623005991 alphaNTD - beta' interaction site [polypeptide binding]; other site 272623005992 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 272623005993 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 272623005994 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 272623005995 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 272623005996 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 272623005997 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272623005998 rRNA binding site [nucleotide binding]; other site 272623005999 predicted 30S ribosome binding site; other site 272623006000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272623006001 HTH-like domain; Region: HTH_21; pfam13276 272623006002 Integrase core domain; Region: rve; cl01316 272623006003 Integrase core domain; Region: rve_3; cl15866 272623006004 Helix-turn-helix domains; Region: HTH; cl00088 272623006005 putative transposase OrfB; Reviewed; Region: PHA02517 272623006006 HTH-like domain; Region: HTH_21; pfam13276 272623006007 Integrase core domain; Region: rve; cl01316 272623006008 Integrase core domain; Region: rve_3; cl15866 272623006009 Helix-turn-helix domains; Region: HTH; cl00088 272623006010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006011 Helix-turn-helix domains; Region: HTH; cl00088 272623006012 adenylate kinase; Reviewed; Region: adk; PRK00279 272623006013 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272623006014 AMP-binding site [chemical binding]; other site 272623006015 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272623006016 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272623006017 SecY translocase; Region: SecY; pfam00344 272623006018 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 272623006019 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272623006020 23S rRNA binding site [nucleotide binding]; other site 272623006021 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272623006022 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272623006023 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272623006024 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272623006025 5S rRNA interface [nucleotide binding]; other site 272623006026 L27 interface [polypeptide binding]; other site 272623006027 23S rRNA interface [nucleotide binding]; other site 272623006028 L5 interface [polypeptide binding]; other site 272623006029 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272623006030 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272623006031 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272623006032 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 272623006033 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 272623006034 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272623006035 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272623006036 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272623006037 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272623006038 KOW motif; Region: KOW; cl00354 272623006039 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 272623006040 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 272623006041 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272623006042 23S rRNA interface [nucleotide binding]; other site 272623006043 putative translocon interaction site; other site 272623006044 signal recognition particle (SRP54) interaction site; other site 272623006045 L23 interface [polypeptide binding]; other site 272623006046 trigger factor interaction site; other site 272623006047 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272623006048 23S rRNA interface [nucleotide binding]; other site 272623006049 5S rRNA interface [nucleotide binding]; other site 272623006050 putative antibiotic binding site [chemical binding]; other site 272623006051 L25 interface [polypeptide binding]; other site 272623006052 L27 interface [polypeptide binding]; other site 272623006053 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272623006054 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272623006055 G-X-X-G motif; other site 272623006056 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272623006057 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272623006058 putative translocon binding site; other site 272623006059 protein-rRNA interface [nucleotide binding]; other site 272623006060 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 272623006061 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272623006062 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272623006063 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272623006064 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 272623006065 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 272623006066 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 272623006067 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 272623006068 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 272623006069 MatE; Region: MatE; cl10513 272623006070 MatE; Region: MatE; cl10513 272623006071 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 272623006072 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272623006073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272623006074 catalytic residue [active] 272623006075 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272623006076 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272623006077 putative homodimer interface [polypeptide binding]; other site 272623006078 KOW motif; Region: KOW; cl00354 272623006079 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 272623006080 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 272623006081 OpgC protein; Region: OpgC_C; cl00792 272623006082 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272623006083 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 272623006084 catalytic triad [active] 272623006085 catalytic triad [active] 272623006086 oxyanion hole [active] 272623006087 Transglycosylase; Region: Transgly; cl07896 272623006088 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272623006089 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623006090 Protein of unknown function (DUF421); Region: DUF421; cl00990 272623006091 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 272623006092 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272623006093 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272623006094 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 272623006095 active site 272623006096 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272623006097 ABC-ATPase subunit interface; other site 272623006098 dimer interface [polypeptide binding]; other site 272623006099 putative PBP binding regions; other site 272623006100 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272623006101 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 272623006102 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272623006103 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272623006104 metal binding site [ion binding]; metal-binding site 272623006105 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272623006106 Helix-turn-helix domains; Region: HTH; cl00088 272623006107 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 272623006108 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 272623006109 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272623006110 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272623006111 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 272623006112 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 272623006113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623006114 Walker A motif; other site 272623006115 ATP binding site [chemical binding]; other site 272623006116 Walker B motif; other site 272623006117 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 272623006118 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 272623006119 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272623006120 generic binding surface II; other site 272623006121 generic binding surface I; other site 272623006122 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272623006123 generic binding surface II; other site 272623006124 generic binding surface I; other site 272623006125 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 272623006126 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272623006127 active site 272623006128 substrate binding site [chemical binding]; other site 272623006129 catalytic site [active] 272623006130 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272623006131 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272623006132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272623006133 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272623006134 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272623006135 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 272623006136 dimer interface [polypeptide binding]; other site 272623006137 motif 1; other site 272623006138 active site 272623006139 motif 2; other site 272623006140 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272623006141 putative deacylase active site [active] 272623006142 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 272623006143 active site 272623006144 motif 3; other site 272623006145 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272623006146 anticodon binding site; other site 272623006147 RIP metalloprotease RseP; Region: TIGR00054 272623006148 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272623006149 active site 272623006150 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272623006151 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272623006152 protein binding site [polypeptide binding]; other site 272623006153 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272623006154 putative substrate binding region [chemical binding]; other site 272623006155 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 272623006156 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 272623006157 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 272623006158 catalytic residue [active] 272623006159 putative FPP diphosphate binding site; other site 272623006160 putative FPP binding hydrophobic cleft; other site 272623006161 dimer interface [polypeptide binding]; other site 272623006162 putative IPP diphosphate binding site; other site 272623006163 Preprotein translocase subunit; Region: YajC; cl00806 272623006164 A new structural DNA glycosylase; Region: AlkD_like; cl11434 272623006165 active site 272623006166 A new structural DNA glycosylase; Region: AlkD_like; cl11434 272623006167 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 272623006168 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 272623006169 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006170 Integrase core domain; Region: rve; cl01316 272623006171 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 272623006172 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272623006173 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272623006174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272623006175 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272623006176 putative ADP-binding pocket [chemical binding]; other site 272623006177 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 272623006178 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272623006179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006180 S-adenosylmethionine binding site [chemical binding]; other site 272623006181 DNA polymerase I; Provisional; Region: PRK05755 272623006182 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272623006183 active site 272623006184 metal binding site 1 [ion binding]; metal-binding site 272623006185 putative 5' ssDNA interaction site; other site 272623006186 metal binding site 3; metal-binding site 272623006187 metal binding site 2 [ion binding]; metal-binding site 272623006188 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272623006189 putative DNA binding site [nucleotide binding]; other site 272623006190 putative metal binding site [ion binding]; other site 272623006191 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272623006192 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272623006193 active site 272623006194 DNA binding site [nucleotide binding] 272623006195 catalytic site [active] 272623006196 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272623006197 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623006198 active site 272623006199 motif I; other site 272623006200 motif II; other site 272623006201 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623006202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272623006203 DNA binding site [nucleotide binding] 272623006204 domain linker motif; other site 272623006205 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272623006206 putative transposase OrfB; Reviewed; Region: PHA02517 272623006207 Integrase core domain; Region: rve; cl01316 272623006208 Helix-turn-helix domains; Region: HTH; cl00088 272623006209 putative transposase OrfB; Reviewed; Region: PHA02517 272623006210 HTH-like domain; Region: HTH_21; pfam13276 272623006211 Integrase core domain; Region: rve; cl01316 272623006212 Integrase core domain; Region: rve_3; cl15866 272623006213 Helix-turn-helix domains; Region: HTH; cl00088 272623006214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272623006215 Helix-turn-helix domains; Region: HTH; cl00088 272623006216 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272623006217 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 272623006218 elongation factor Ts; Provisional; Region: tsf; PRK09377 272623006219 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 272623006220 Elongation factor TS; Region: EF_TS; pfam00889 272623006221 Elongation factor TS; Region: EF_TS; pfam00889 272623006222 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272623006223 rRNA interaction site [nucleotide binding]; other site 272623006224 S8 interaction site; other site 272623006225 putative laminin-1 binding site; other site 272623006226 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 272623006227 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272623006228 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272623006229 putative catalytic cysteine [active] 272623006230 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272623006231 putative active site [active] 272623006232 metal binding site [ion binding]; metal-binding site 272623006233 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272623006234 dimer interface [polypeptide binding]; other site 272623006235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006236 FeS/SAM binding site; other site 272623006237 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272623006238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006239 FeS/SAM binding site; other site 272623006240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006241 Helix-turn-helix domains; Region: HTH; cl00088 272623006242 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623006243 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272623006244 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 272623006245 protein binding site [polypeptide binding]; other site 272623006246 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272623006247 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272623006248 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272623006249 active site 272623006250 (T/H)XGH motif; other site 272623006251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006252 S-adenosylmethionine binding site [chemical binding]; other site 272623006253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 272623006255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272623006256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006257 putative substrate translocation pore; other site 272623006258 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272623006259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272623006260 DNA binding residues [nucleotide binding] 272623006261 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 272623006262 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272623006263 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272623006264 active site 272623006265 dimer interface [polypeptide binding]; other site 272623006266 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272623006267 dimer interface [polypeptide binding]; other site 272623006268 active site 272623006269 Flagellin N-methylase; Region: FliB; cl00497 272623006270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006271 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272623006272 NAD(P) binding site [chemical binding]; other site 272623006273 active site 272623006274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272623006275 dimerization interface [polypeptide binding]; other site 272623006276 putative DNA binding site [nucleotide binding]; other site 272623006277 putative Zn2+ binding site [ion binding]; other site 272623006278 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272623006279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272623006280 active site 272623006281 HIGH motif; other site 272623006282 nucleotide binding site [chemical binding]; other site 272623006283 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272623006284 active site 272623006285 KMSKS motif; other site 272623006286 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272623006287 tRNA binding surface [nucleotide binding]; other site 272623006288 anticodon binding site; other site 272623006289 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272623006290 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 272623006291 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 272623006292 Protein of unknown function (DUF419); Region: DUF419; cl15265 272623006293 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 272623006294 B3/4 domain; Region: B3_4; cl11458 272623006295 TRAM domain; Region: TRAM; cl01282 272623006296 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272623006297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272623006298 S-adenosylmethionine binding site [chemical binding]; other site 272623006299 legume lectins; Region: lectin_L-type; cl14058 272623006300 carbohydrate binding site [chemical binding]; other site 272623006301 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272623006302 MucBP domain; Region: MucBP; pfam06458 272623006303 MucBP domain; Region: MucBP; pfam06458 272623006304 MucBP domain; Region: MucBP; pfam06458 272623006305 MucBP domain; Region: MucBP; pfam06458 272623006306 legume lectins; Region: lectin_L-type; cl14058 272623006307 homotetramer interaction site [polypeptide binding]; other site 272623006308 homodimer interaction site [polypeptide binding]; other site 272623006309 carbohydrate binding site [chemical binding]; other site 272623006310 RecX family; Region: RecX; cl00936 272623006311 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272623006312 Helix-turn-helix domains; Region: HTH; cl00088 272623006313 Integrase core domain; Region: rve; cl01316 272623006314 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272623006315 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272623006316 N- and C-terminal domain interface [polypeptide binding]; other site 272623006317 putative active site [active] 272623006318 catalytic site [active] 272623006319 metal binding site [ion binding]; metal-binding site 272623006320 carbohydrate binding site [chemical binding]; other site 272623006321 ATP binding site [chemical binding]; other site 272623006322 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 272623006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006324 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272623006325 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272623006326 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272623006327 putative active site [active] 272623006328 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 272623006329 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272623006330 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272623006331 putative active site [active] 272623006332 putative metal binding site [ion binding]; other site 272623006333 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 272623006334 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272623006335 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272623006336 dimer interface [polypeptide binding]; other site 272623006337 ssDNA binding site [nucleotide binding]; other site 272623006338 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623006339 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 272623006340 Bacitracin resistance protein BacA; Region: BacA; cl00858 272623006341 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 272623006342 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272623006343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623006344 Walker A motif; other site 272623006345 ATP binding site [chemical binding]; other site 272623006346 Walker B motif; other site 272623006347 arginine finger; other site 272623006348 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272623006349 substrate binding site [chemical binding]; other site 272623006350 GAF domain; Region: GAF; cl00853 272623006351 Chorismate mutase type II; Region: CM_2; cl00693 272623006352 glutamine synthetase, type I; Region: GlnA; TIGR00653 272623006353 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272623006354 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272623006355 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272623006356 DNA binding residues [nucleotide binding] 272623006357 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272623006358 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 272623006359 active site 272623006360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623006361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 272623006362 Walker A/P-loop; other site 272623006363 ATP binding site [chemical binding]; other site 272623006364 Q-loop/lid; other site 272623006365 ABC transporter signature motif; other site 272623006366 Walker B; other site 272623006367 D-loop; other site 272623006368 H-loop/switch region; other site 272623006369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623006370 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272623006371 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272623006372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272623006373 Walker A motif; other site 272623006374 ATP binding site [chemical binding]; other site 272623006375 Walker B motif; other site 272623006376 arginine finger; other site 272623006377 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272623006378 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272623006379 RuvA N terminal domain; Region: RuvA_N; pfam01330 272623006380 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272623006381 helix-hairpin-helix signature motif; other site 272623006382 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272623006383 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272623006384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272623006385 ATP binding site [chemical binding]; other site 272623006386 Mg2+ binding site [ion binding]; other site 272623006387 G-X-G motif; other site 272623006388 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272623006389 ATP binding site [chemical binding]; other site 272623006390 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 272623006391 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272623006392 MutS domain I; Region: MutS_I; pfam01624 272623006393 MutS domain II; Region: MutS_II; pfam05188 272623006394 MutS family domain IV; Region: MutS_IV; pfam05190 272623006395 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 272623006396 Walker A/P-loop; other site 272623006397 ATP binding site [chemical binding]; other site 272623006398 Q-loop/lid; other site 272623006399 ABC transporter signature motif; other site 272623006400 Walker B; other site 272623006401 D-loop; other site 272623006402 H-loop/switch region; other site 272623006403 Protein of unknown function (DUF964); Region: DUF964; cl01483 272623006404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272623006405 non-specific DNA binding site [nucleotide binding]; other site 272623006406 salt bridge; other site 272623006407 sequence-specific DNA binding site [nucleotide binding]; other site 272623006408 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272623006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006410 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 272623006411 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 272623006412 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272623006413 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272623006414 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272623006415 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 272623006416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272623006417 active site 272623006418 motif I; other site 272623006419 motif II; other site 272623006420 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623006421 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 272623006422 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272623006423 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272623006424 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 272623006425 putative active site [active] 272623006426 chaperone protein DnaJ; Provisional; Region: PRK14276 272623006427 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272623006428 HSP70 interaction site [polypeptide binding]; other site 272623006429 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272623006430 substrate binding site [polypeptide binding]; other site 272623006431 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272623006432 Zn binding sites [ion binding]; other site 272623006433 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272623006434 substrate binding site [polypeptide binding]; other site 272623006435 dimer interface [polypeptide binding]; other site 272623006436 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 272623006437 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272623006438 aspartate racemase; Region: asp_race; TIGR00035 272623006439 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 272623006440 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272623006441 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272623006442 active site 272623006443 dimer interface [polypeptide binding]; other site 272623006444 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272623006445 Ligand Binding Site [chemical binding]; other site 272623006446 Molecular Tunnel; other site 272623006447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272623006448 NlpC/P60 family; Region: NLPC_P60; cl11438 272623006449 rod shape-determining protein MreD; Region: MreD; cl01087 272623006450 rod shape-determining protein MreC; Region: MreC; pfam04085 272623006451 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 272623006452 nudix motif; other site 272623006453 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272623006454 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272623006455 active site 272623006456 dimer interface [polypeptide binding]; other site 272623006457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272623006458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272623006459 ligand binding site [chemical binding]; other site 272623006460 flexible hinge region; other site 272623006461 Helix-turn-helix domains; Region: HTH; cl00088 272623006462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272623006463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 272623006464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272623006465 Ligand Binding Site [chemical binding]; other site 272623006466 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272623006467 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272623006468 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 272623006469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272623006470 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; pfam09989 272623006471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272623006472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272623006473 Helix-turn-helix domains; Region: HTH; cl00088 272623006474 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272623006475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272623006476 RNA binding surface [nucleotide binding]; other site 272623006477 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 272623006478 active site 272623006479 uracil binding [chemical binding]; other site 272623006480 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272623006481 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272623006482 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 272623006483 G1 box; other site 272623006484 GTP/Mg2+ binding site [chemical binding]; other site 272623006485 Switch I region; other site 272623006486 G2 box; other site 272623006487 Switch II region; other site 272623006488 G3 box; other site 272623006489 G4 box; other site 272623006490 G5 box; other site 272623006491 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272623006492 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272623006493 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272623006494 generic binding surface II; other site 272623006495 ssDNA binding site; other site 272623006496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272623006497 ATP binding site [chemical binding]; other site 272623006498 putative Mg++ binding site [ion binding]; other site 272623006499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272623006500 nucleotide binding region [chemical binding]; other site 272623006501 ATP-binding site [chemical binding]; other site 272623006502 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272623006503 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272623006504 PhnA protein; Region: PhnA; pfam03831 272623006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006506 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272623006507 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 272623006508 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 272623006509 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272623006510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272623006511 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 272623006512 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272623006513 Helix-turn-helix domains; Region: HTH; cl00088 272623006514 oxidoreductase; Provisional; Region: PRK06196 272623006515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272623006516 NAD(P) binding site [chemical binding]; other site 272623006517 active site 272623006518 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 272623006519 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 272623006520 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272623006521 23S rRNA interface [nucleotide binding]; other site 272623006522 L3 interface [polypeptide binding]; other site 272623006523 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272623006524 FtsX-like permease family; Region: FtsX; pfam02687 272623006525 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272623006526 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 272623006527 Walker A/P-loop; other site 272623006528 ATP binding site [chemical binding]; other site 272623006529 Q-loop/lid; other site 272623006530 ABC transporter signature motif; other site 272623006531 Walker B; other site 272623006532 D-loop; other site 272623006533 H-loop/switch region; other site 272623006534 ribonuclease HIII; Provisional; Region: PRK00996 272623006535 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 272623006536 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272623006537 RNA/DNA hybrid binding site [nucleotide binding]; other site 272623006538 active site 272623006539 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272623006540 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 272623006541 Catalytic site [active] 272623006542 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272623006543 pur operon repressor; Provisional; Region: PRK09213 272623006544 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272623006545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272623006546 active site 272623006547 elongation factor G; Reviewed; Region: PRK00007 272623006548 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272623006549 G1 box; other site 272623006550 putative GEF interaction site [polypeptide binding]; other site 272623006551 GTP/Mg2+ binding site [chemical binding]; other site 272623006552 Switch I region; other site 272623006553 G2 box; other site 272623006554 G3 box; other site 272623006555 Switch II region; other site 272623006556 G4 box; other site 272623006557 G5 box; other site 272623006558 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272623006559 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272623006560 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272623006561 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 272623006562 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272623006563 S17 interaction site [polypeptide binding]; other site 272623006564 S8 interaction site; other site 272623006565 16S rRNA interaction site [nucleotide binding]; other site 272623006566 streptomycin interaction site [chemical binding]; other site 272623006567 23S rRNA interaction site [nucleotide binding]; other site 272623006568 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272623006569 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272623006570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 272623006571 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 272623006572 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272623006573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 272623006575 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 272623006576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272623006577 FeS/SAM binding site; other site