-- dump date   	20120504_151403
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
557598000001	L-aspartate oxidase; Provisional; Region: PRK09077
557598000002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000003	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
557598000004	DsrE/DsrF-like family; Region: DrsE; cl00672
557598000005	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
557598000006	active site
557598000007	HslU subunit interaction site [polypeptide binding]; other site
557598000008	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
557598000009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598000010	Walker A motif; other site
557598000011	ATP binding site [chemical binding]; other site
557598000012	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000013	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
557598000014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
557598000015	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
557598000016	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
557598000017	active site
557598000018	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
557598000019	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
557598000020	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
557598000021	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
557598000022	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
557598000023	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000025	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
557598000026	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
557598000027	active site residue [active]
557598000028	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
557598000029	ligand binding site [chemical binding]; other site
557598000030	active site
557598000031	UGI interface [polypeptide binding]; other site
557598000032	catalytic site [active]
557598000033	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
557598000034	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
557598000035	putative active site [active]
557598000036	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
557598000037	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
557598000038	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
557598000039	ATP binding site [chemical binding]; other site
557598000040	substrate binding site [chemical binding]; other site
557598000041	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
557598000042	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
557598000043	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
557598000044	inhibitor-cofactor binding pocket; inhibition site
557598000045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598000046	catalytic residue [active]
557598000047	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598000048	diaminopimelate decarboxylase; Region: lysA; TIGR01048
557598000049	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
557598000050	active site
557598000051	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
557598000052	substrate binding site [chemical binding]; other site
557598000053	catalytic residues [active]
557598000054	dimer interface [polypeptide binding]; other site
557598000055	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238
557598000056	putative iron binding site [ion binding]; other site
557598000057	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
557598000058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000059	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
557598000060	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
557598000061	Walker A/P-loop; other site
557598000062	ATP binding site [chemical binding]; other site
557598000063	Q-loop/lid; other site
557598000064	ABC transporter signature motif; other site
557598000065	Walker B; other site
557598000066	D-loop; other site
557598000067	H-loop/switch region; other site
557598000068	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
557598000069	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
557598000070	substrate binding pocket [chemical binding]; other site
557598000071	membrane-bound complex binding site; other site
557598000072	hinge residues; other site
557598000073	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
557598000074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598000075	dimer interface [polypeptide binding]; other site
557598000076	conserved gate region; other site
557598000077	putative PBP binding loops; other site
557598000078	ABC-ATPase subunit interface; other site
557598000079	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
557598000080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598000081	dimer interface [polypeptide binding]; other site
557598000082	conserved gate region; other site
557598000083	putative PBP binding loops; other site
557598000084	ABC-ATPase subunit interface; other site
557598000085	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
557598000086	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
557598000087	Walker A/P-loop; other site
557598000088	ATP binding site [chemical binding]; other site
557598000089	Q-loop/lid; other site
557598000090	ABC transporter signature motif; other site
557598000091	Walker B; other site
557598000092	D-loop; other site
557598000093	H-loop/switch region; other site
557598000094	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
557598000095	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
557598000096	Walker A motif; other site
557598000097	ATP binding site [chemical binding]; other site
557598000098	Walker B motif; other site
557598000099	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
557598000100	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
557598000101	catalytic residue [active]
557598000102	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
557598000103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000104	Cytochrome c; Region: Cytochrom_C; cl11414
557598000105	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
557598000106	NeuB family; Region: NeuB; cl00496
557598000107	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
557598000108	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
557598000109	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
557598000110	GTP binding site; other site
557598000111	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
557598000112	MoaE homodimer interface [polypeptide binding]; other site
557598000113	MoaD interaction [polypeptide binding]; other site
557598000114	active site residues [active]
557598000115	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
557598000116	MoaE interaction surface [polypeptide binding]; other site
557598000117	MoeB interaction surface [polypeptide binding]; other site
557598000118	thiocarboxylated glycine; other site
557598000119	hypothetical protein; Provisional; Region: PRK08185
557598000120	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
557598000121	intersubunit interface [polypeptide binding]; other site
557598000122	active site
557598000123	zinc binding site [ion binding]; other site
557598000124	Na+ binding site [ion binding]; other site
557598000125	LysE type translocator; Region: LysE; cl00565
557598000126	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
557598000127	Phosphoglycerate kinase; Region: PGK; pfam00162
557598000128	substrate binding site [chemical binding]; other site
557598000129	hinge regions; other site
557598000130	ADP binding site [chemical binding]; other site
557598000131	catalytic site [active]
557598000132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000133	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
557598000134	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
557598000135	transketolase; Reviewed; Region: PRK12753
557598000136	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
557598000137	TPP-binding site [chemical binding]; other site
557598000138	dimer interface [polypeptide binding]; other site
557598000139	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
557598000140	PYR/PP interface [polypeptide binding]; other site
557598000141	dimer interface [polypeptide binding]; other site
557598000142	TPP binding site [chemical binding]; other site
557598000143	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
557598000144	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
557598000145	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
557598000146	active site
557598000147	FMN binding site [chemical binding]; other site
557598000148	2,4-decadienoyl-CoA binding site; other site
557598000149	catalytic residue [active]
557598000150	4Fe-4S cluster binding site [ion binding]; other site
557598000151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598000152	Major Facilitator Superfamily; Region: MFS_1; pfam07690
557598000153	putative substrate translocation pore; other site
557598000154	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
557598000155	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
557598000156	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
557598000157	aspartate racemase; Region: asp_race; TIGR00035
557598000158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598000159	gamma-glutamyl kinase; Provisional; Region: PRK05429
557598000160	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
557598000161	nucleotide binding site [chemical binding]; other site
557598000162	homotetrameric interface [polypeptide binding]; other site
557598000163	putative phosphate binding site [ion binding]; other site
557598000164	putative allosteric binding site; other site
557598000165	PUA domain; Region: PUA; cl00607
557598000166	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
557598000167	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
557598000168	ATP binding site [chemical binding]; other site
557598000169	substrate interface [chemical binding]; other site
557598000170	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
557598000171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000172	active site
557598000173	phosphorylation site [posttranslational modification]
557598000174	intermolecular recognition site; other site
557598000175	dimerization interface [polypeptide binding]; other site
557598000176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598000177	Walker A motif; other site
557598000178	ATP binding site [chemical binding]; other site
557598000179	Walker B motif; other site
557598000180	arginine finger; other site
557598000181	Helix-turn-helix domains; Region: HTH; cl00088
557598000182	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
557598000183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598000184	dimerization interface [polypeptide binding]; other site
557598000185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598000186	dimer interface [polypeptide binding]; other site
557598000187	phosphorylation site [posttranslational modification]
557598000188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000189	ATP binding site [chemical binding]; other site
557598000190	Mg2+ binding site [ion binding]; other site
557598000191	G-X-G motif; other site
557598000192	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
557598000193	16S rRNA methyltransferase B; Provisional; Region: PRK10901
557598000194	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
557598000195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598000196	Peptidase family M48; Region: Peptidase_M48; cl12018
557598000197	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
557598000198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000199	active site
557598000200	phosphorylation site [posttranslational modification]
557598000201	intermolecular recognition site; other site
557598000202	dimerization interface [polypeptide binding]; other site
557598000203	LytTr DNA-binding domain; Region: LytTR; cl04498
557598000204	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
557598000205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000206	active site
557598000207	phosphorylation site [posttranslational modification]
557598000208	intermolecular recognition site; other site
557598000209	dimerization interface [polypeptide binding]; other site
557598000210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
557598000211	binding surface
557598000212	TPR motif; other site
557598000213	Tetratricopeptide repeat; Region: TPR_16; pfam13432
557598000214	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
557598000215	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000216	Family description; Region: UvrD_C_2; cl15862
557598000217	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598000218	substrate binding site [chemical binding]; other site
557598000219	oxyanion hole (OAH) forming residues; other site
557598000220	trimer interface [polypeptide binding]; other site
557598000221	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
557598000222	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
557598000223	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
557598000224	active site
557598000225	uracil binding [chemical binding]; other site
557598000226	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
557598000227	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
557598000228	HemY protein N-terminus; Region: HemY_N; pfam07219
557598000229	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
557598000230	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
557598000231	active site
557598000232	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
557598000233	active site residue [active]
557598000234	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
557598000235	CrcB-like protein; Region: CRCB; cl09114
557598000236	Maf-like protein; Region: Maf; pfam02545
557598000237	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
557598000238	active site
557598000239	dimer interface [polypeptide binding]; other site
557598000240	ribonuclease G; Provisional; Region: PRK11712
557598000241	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
557598000242	homodimer interface [polypeptide binding]; other site
557598000243	oligonucleotide binding site [chemical binding]; other site
557598000244	tRNA pseudouridine isomerase C: Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi).  No cofactors are required. TruC makes psi65 in tRNAs.  This psi residue is not...; Region: PseudoU_synth_TruC; cd02563
557598000245	probable active site [active]
557598000246	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
557598000247	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
557598000248	potential catalytic triad [active]
557598000249	conserved cys residue [active]
557598000250	Cupin domain; Region: Cupin_2; cl09118
557598000251	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
557598000252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598000253	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598000254	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598000255	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
557598000256	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598000257	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598000258	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
557598000259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598000260	Walker A motif; other site
557598000261	ATP binding site [chemical binding]; other site
557598000262	Walker B motif; other site
557598000263	arginine finger; other site
557598000264	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
557598000265	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
557598000266	substrate binding site [chemical binding]; other site
557598000267	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
557598000268	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
557598000269	RNB domain; Region: RNB; pfam00773
557598000270	Exoribonuclease R [Transcription]; Region: VacB; COG0557
557598000271	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
557598000272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000273	active site
557598000274	phosphorylation site [posttranslational modification]
557598000275	intermolecular recognition site; other site
557598000276	dimerization interface [polypeptide binding]; other site
557598000277	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598000278	metal binding site [ion binding]; metal-binding site
557598000279	active site
557598000280	I-site; other site
557598000281	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
557598000282	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598000283	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
557598000284	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
557598000285	CAP-like domain; other site
557598000286	active site
557598000287	primary dimer interface [polypeptide binding]; other site
557598000288	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
557598000289	active site
557598000290	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
557598000291	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598000292	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598000293	catalytic residue [active]
557598000294	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
557598000295	DNA utilization protein GntX; Provisional; Region: PRK11595
557598000296	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
557598000297	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
557598000298	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
557598000299	Sporulation related domain; Region: SPOR; cl10051
557598000300	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
557598000301	serine acetyltransferase; Provisional; Region: cysE; PRK11132
557598000302	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
557598000303	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
557598000304	trimer interface [polypeptide binding]; other site
557598000305	active site
557598000306	substrate binding site [chemical binding]; other site
557598000307	CoA binding site [chemical binding]; other site
557598000308	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
557598000309	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
557598000310	NADP binding site [chemical binding]; other site
557598000311	dimer interface [polypeptide binding]; other site
557598000312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598000313	dimer interface [polypeptide binding]; other site
557598000314	phosphorylation site [posttranslational modification]
557598000315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000316	ATP binding site [chemical binding]; other site
557598000317	Mg2+ binding site [ion binding]; other site
557598000318	G-X-G motif; other site
557598000319	Response regulator receiver domain; Region: Response_reg; pfam00072
557598000320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000321	active site
557598000322	phosphorylation site [posttranslational modification]
557598000323	intermolecular recognition site; other site
557598000324	dimerization interface [polypeptide binding]; other site
557598000325	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
557598000326	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
557598000327	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
557598000328	substrate binding pocket [chemical binding]; other site
557598000329	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
557598000330	B12 binding site [chemical binding]; other site
557598000331	cobalt ligand [ion binding]; other site
557598000332	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
557598000333	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
557598000334	DoxX; Region: DoxX; cl00976
557598000335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598000336	non-specific DNA binding site [nucleotide binding]; other site
557598000337	salt bridge; other site
557598000338	sequence-specific DNA binding site [nucleotide binding]; other site
557598000339	YaeQ protein; Region: YaeQ; cl01913
557598000340	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
557598000341	fructokinase; Reviewed; Region: PRK09557
557598000342	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
557598000343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598000344	putative substrate translocation pore; other site
557598000345	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
557598000346	Cache domain; Region: Cache_1; pfam02743
557598000347	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
557598000348	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598000349	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598000350	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598000351	dimer interface [polypeptide binding]; other site
557598000352	putative CheW interface [polypeptide binding]; other site
557598000353	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
557598000354	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
557598000355	active site
557598000356	nucleophile elbow; other site
557598000357	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
557598000358	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
557598000359	Lipopolysaccharide-assembly; Region: LptE; cl01125
557598000360	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
557598000361	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
557598000362	HIGH motif; other site
557598000363	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
557598000364	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598000365	active site
557598000366	KMSKS motif; other site
557598000367	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
557598000368	tRNA binding surface [nucleotide binding]; other site
557598000369	K+ potassium transporter; Region: K_trans; cl15781
557598000370	potassium uptake protein; Region: kup; TIGR00794
557598000371	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
557598000372	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
557598000373	metal binding site [ion binding]; metal-binding site
557598000374	dimer interface [polypeptide binding]; other site
557598000375	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598000376	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
557598000377	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
557598000378	amidase catalytic site [active]
557598000379	Zn binding residues [ion binding]; other site
557598000380	substrate binding site [chemical binding]; other site
557598000381	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
557598000382	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598000383	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598000384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598000385	2-isopropylmalate synthase; Validated; Region: PRK00915
557598000386	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
557598000387	active site
557598000388	catalytic residues [active]
557598000389	metal binding site [ion binding]; metal-binding site
557598000390	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
557598000391	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
557598000392	PAS fold; Region: PAS_4; pfam08448
557598000393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598000394	putative active site [active]
557598000395	heme pocket [chemical binding]; other site
557598000396	PAS fold; Region: PAS_3; pfam08447
557598000397	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598000398	metal binding site [ion binding]; metal-binding site
557598000399	active site
557598000400	I-site; other site
557598000401	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598000402	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
557598000403	E3 interaction surface; other site
557598000404	lipoyl attachment site [posttranslational modification]; other site
557598000405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000406	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
557598000407	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
557598000408	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
557598000409	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
557598000410	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
557598000411	E3 interaction surface; other site
557598000412	lipoyl attachment site [posttranslational modification]; other site
557598000413	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
557598000414	E3 interaction surface; other site
557598000415	lipoyl attachment site [posttranslational modification]; other site
557598000416	e3 binding domain; Region: E3_binding; pfam02817
557598000417	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
557598000418	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
557598000419	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
557598000420	dimer interface [polypeptide binding]; other site
557598000421	TPP-binding site [chemical binding]; other site
557598000422	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
557598000423	Peptidase family M48; Region: Peptidase_M48; cl12018
557598000424	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
557598000425	active site residue [active]
557598000426	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
557598000427	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
557598000428	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
557598000429	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598000430	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598000431	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
557598000432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
557598000433	dimerization interface [polypeptide binding]; other site
557598000434	putative DNA binding site [nucleotide binding]; other site
557598000435	putative Zn2+ binding site [ion binding]; other site
557598000436	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
557598000437	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
557598000438	active site
557598000439	(T/H)XGH motif; other site
557598000440	Oligomerisation domain; Region: Oligomerisation; cl00519
557598000441	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
557598000442	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
557598000443	PhnA protein; Region: PhnA; pfam03831
557598000444	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
557598000445	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
557598000446	DNA binding site [nucleotide binding]
557598000447	active site
557598000448	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
557598000449	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
557598000450	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
557598000451	guanine deaminase; Provisional; Region: PRK09228
557598000452	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
557598000453	active site
557598000454	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
557598000455	N-acetyl-D-glucosamine binding site [chemical binding]; other site
557598000456	catalytic residue [active]
557598000457	RDD family; Region: RDD; cl00746
557598000458	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
557598000459	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
557598000460	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
557598000461	PYR/PP interface [polypeptide binding]; other site
557598000462	dimer interface [polypeptide binding]; other site
557598000463	TPP binding site [chemical binding]; other site
557598000464	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
557598000465	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
557598000466	TPP-binding site [chemical binding]; other site
557598000467	dimer interface [polypeptide binding]; other site
557598000468	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
557598000469	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
557598000470	putative valine binding site [chemical binding]; other site
557598000471	dimer interface [polypeptide binding]; other site
557598000472	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
557598000473	ketol-acid reductoisomerase; Provisional; Region: PRK05479
557598000474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000475	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
557598000476	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
557598000477	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
557598000478	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
557598000479	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
557598000480	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
557598000481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000482	active site
557598000483	phosphorylation site [posttranslational modification]
557598000484	intermolecular recognition site; other site
557598000485	dimerization interface [polypeptide binding]; other site
557598000486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598000487	DNA binding site [nucleotide binding]
557598000488	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
557598000489	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
557598000490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598000491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598000492	dimer interface [polypeptide binding]; other site
557598000493	phosphorylation site [posttranslational modification]
557598000494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000495	ATP binding site [chemical binding]; other site
557598000496	Mg2+ binding site [ion binding]; other site
557598000497	G-X-G motif; other site
557598000498	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
557598000499	putative active site [active]
557598000500	catalytic residue [active]
557598000501	AAA domain; Region: AAA_26; pfam13500
557598000502	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000503	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000504	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
557598000505	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
557598000506	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598000507	Cytochrome c; Region: Cytochrom_C; cl11414
557598000508	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
557598000509	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
557598000510	Subunit I/III interface [polypeptide binding]; other site
557598000511	D-pathway; other site
557598000512	Subunit I/VIIc interface [polypeptide binding]; other site
557598000513	Subunit I/IV interface [polypeptide binding]; other site
557598000514	Subunit I/II interface [polypeptide binding]; other site
557598000515	Low-spin heme (heme a) binding site [chemical binding]; other site
557598000516	Subunit I/VIIa interface [polypeptide binding]; other site
557598000517	Subunit I/VIa interface [polypeptide binding]; other site
557598000518	Dimer interface; other site
557598000519	Putative water exit pathway; other site
557598000520	Binuclear center (heme a3/CuB) [ion binding]; other site
557598000521	K-pathway; other site
557598000522	Subunit I/Vb interface [polypeptide binding]; other site
557598000523	Putative proton exit pathway; other site
557598000524	Subunit I/VIb interface; other site
557598000525	Subunit I/VIc interface [polypeptide binding]; other site
557598000526	Electron transfer pathway; other site
557598000527	Subunit I/VIIIb interface [polypeptide binding]; other site
557598000528	Subunit I/VIIb interface [polypeptide binding]; other site
557598000529	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
557598000530	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
557598000531	Subunit III/VIIa interface [polypeptide binding]; other site
557598000532	Phospholipid binding site [chemical binding]; other site
557598000533	Subunit I/III interface [polypeptide binding]; other site
557598000534	Subunit III/VIb interface [polypeptide binding]; other site
557598000535	Subunit III/VIa interface; other site
557598000536	Subunit III/Vb interface [polypeptide binding]; other site
557598000537	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321
557598000538	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
557598000539	UbiA prenyltransferase family; Region: UbiA; cl00337
557598000540	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
557598000541	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
557598000542	Cu(I) binding site [ion binding]; other site
557598000543	Flagellar regulator YcgR; Region: YcgR; pfam07317
557598000544	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
557598000545	PilZ domain; Region: PilZ; cl01260
557598000546	ATP phosphoribosyltransferase; Region: HisG; cl15266
557598000547	LysE type translocator; Region: LysE; cl00565
557598000548	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
557598000549	histidinol dehydrogenase; Region: hisD; TIGR00069
557598000550	NAD binding site [chemical binding]; other site
557598000551	dimerization interface [polypeptide binding]; other site
557598000552	product binding site; other site
557598000553	substrate binding site [chemical binding]; other site
557598000554	zinc binding site [ion binding]; other site
557598000555	catalytic residues [active]
557598000556	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
557598000557	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598000558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598000559	homodimer interface [polypeptide binding]; other site
557598000560	catalytic residue [active]
557598000561	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
557598000562	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
557598000563	putative active site pocket [active]
557598000564	4-fold oligomerization interface [polypeptide binding]; other site
557598000565	metal binding residues [ion binding]; metal-binding site
557598000566	3-fold/trimer interface [polypeptide binding]; other site
557598000567	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
557598000568	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
557598000569	putative active site [active]
557598000570	oxyanion strand; other site
557598000571	catalytic triad [active]
557598000572	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
557598000573	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
557598000574	catalytic residues [active]
557598000575	GlpM protein; Region: GlpM; cl01212
557598000576	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
557598000577	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
557598000578	substrate binding site [chemical binding]; other site
557598000579	glutamase interaction surface [polypeptide binding]; other site
557598000580	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
557598000581	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
557598000582	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
557598000583	nucleotide binding site/active site [active]
557598000584	HIT family signature motif; other site
557598000585	catalytic residue [active]
557598000586	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
557598000587	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
557598000588	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
557598000589	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
557598000590	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
557598000591	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
557598000592	active site
557598000593	sensor protein RstB; Provisional; Region: PRK10604
557598000594	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598000595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598000596	dimer interface [polypeptide binding]; other site
557598000597	phosphorylation site [posttranslational modification]
557598000598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000599	ATP binding site [chemical binding]; other site
557598000600	Mg2+ binding site [ion binding]; other site
557598000601	G-X-G motif; other site
557598000602	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
557598000603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000604	active site
557598000605	phosphorylation site [posttranslational modification]
557598000606	intermolecular recognition site; other site
557598000607	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598000608	DNA binding site [nucleotide binding]
557598000609	Cytochrome c [Energy production and conversion]; Region: COG3258
557598000610	Cytochrome c; Region: Cytochrom_C; cl11414
557598000611	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
557598000612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000613	active site
557598000614	phosphorylation site [posttranslational modification]
557598000615	intermolecular recognition site; other site
557598000616	dimerization interface [polypeptide binding]; other site
557598000617	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598000618	DNA binding residues [nucleotide binding]
557598000619	dimerization interface [polypeptide binding]; other site
557598000620	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
557598000621	NMT1-like family; Region: NMT1_2; cl15260
557598000622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
557598000623	dimer interface [polypeptide binding]; other site
557598000624	phosphorylation site [posttranslational modification]
557598000625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000626	ATP binding site [chemical binding]; other site
557598000627	Mg2+ binding site [ion binding]; other site
557598000628	G-X-G motif; other site
557598000629	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
557598000630	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
557598000631	dimer interface [polypeptide binding]; other site
557598000632	active site
557598000633	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
557598000634	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
557598000635	DNA binding residues [nucleotide binding]
557598000636	putative dimer interface [polypeptide binding]; other site
557598000637	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
557598000638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000639	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
557598000640	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
557598000641	AMP-binding enzyme; Region: AMP-binding; cl15778
557598000642	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
557598000643	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
557598000644	Walker A/P-loop; other site
557598000645	ATP binding site [chemical binding]; other site
557598000646	Q-loop/lid; other site
557598000647	ABC transporter signature motif; other site
557598000648	Walker B; other site
557598000649	D-loop; other site
557598000650	H-loop/switch region; other site
557598000651	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
557598000652	TM-ABC transporter signature motif; other site
557598000653	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
557598000654	TM-ABC transporter signature motif; other site
557598000655	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
557598000656	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
557598000657	putative ligand binding site [chemical binding]; other site
557598000658	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
557598000659	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
557598000660	Walker A/P-loop; other site
557598000661	ATP binding site [chemical binding]; other site
557598000662	Q-loop/lid; other site
557598000663	ABC transporter signature motif; other site
557598000664	Walker B; other site
557598000665	D-loop; other site
557598000666	H-loop/switch region; other site
557598000667	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
557598000668	AMP-binding enzyme; Region: AMP-binding; cl15778
557598000669	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
557598000670	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
557598000671	tetrameric interface [polypeptide binding]; other site
557598000672	NAD binding site [chemical binding]; other site
557598000673	catalytic residues [active]
557598000674	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
557598000675	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
557598000676	substrate binding pocket [chemical binding]; other site
557598000677	FAD binding site [chemical binding]; other site
557598000678	catalytic base [active]
557598000679	enoyl-CoA hydratase; Provisional; Region: PRK09076
557598000680	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598000681	substrate binding site [chemical binding]; other site
557598000682	oxyanion hole (OAH) forming residues; other site
557598000683	trimer interface [polypeptide binding]; other site
557598000684	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
557598000685	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598000686	substrate binding site [chemical binding]; other site
557598000687	oxyanion hole (OAH) forming residues; other site
557598000688	trimer interface [polypeptide binding]; other site
557598000689	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
557598000690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000691	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
557598000692	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598000693	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
557598000694	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
557598000695	Walker A/P-loop; other site
557598000696	ATP binding site [chemical binding]; other site
557598000697	Q-loop/lid; other site
557598000698	ABC transporter signature motif; other site
557598000699	Walker B; other site
557598000700	D-loop; other site
557598000701	H-loop/switch region; other site
557598000702	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
557598000703	FtsX-like permease family; Region: FtsX; cl15850
557598000704	macrolide transporter subunit MacA; Provisional; Region: PRK11578
557598000705	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598000706	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598000707	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
557598000708	Ca2+ binding site [ion binding]; other site
557598000709	EF-hand domain pair; Region: EF_hand_5; pfam13499
557598000710	EF-hand domain pair; Region: EF_hand_5; pfam13499
557598000711	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
557598000712	pseudo EF-hand loop; other site
557598000713	peptide binding pocket; other site
557598000714	Ca2+ binding site [ion binding]; other site
557598000715	Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A...; Region: EH; cd00052
557598000716	pseudo EF-hand loop; other site
557598000717	peptide binding pocket; other site
557598000718	EF-hand domain pair; Region: EF_hand_5; pfam13499
557598000719	Ca2+ binding site [ion binding]; other site
557598000720	Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A...; Region: EH; cd00052
557598000721	pseudo EF-hand loop; other site
557598000722	peptide binding pocket; other site
557598000723	Ca2+ binding site [ion binding]; other site
557598000724	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
557598000725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598000726	active site
557598000727	phosphorylation site [posttranslational modification]
557598000728	intermolecular recognition site; other site
557598000729	dimerization interface [polypeptide binding]; other site
557598000730	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598000731	DNA binding site [nucleotide binding]
557598000732	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
557598000733	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598000734	dimerization interface [polypeptide binding]; other site
557598000735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598000736	dimer interface [polypeptide binding]; other site
557598000737	phosphorylation site [posttranslational modification]
557598000738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598000739	ATP binding site [chemical binding]; other site
557598000740	Mg2+ binding site [ion binding]; other site
557598000741	G-X-G motif; other site
557598000742	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598000743	Helix-turn-helix domains; Region: HTH; cl00088
557598000744	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
557598000745	putative effector binding pocket; other site
557598000746	putative dimerization interface [polypeptide binding]; other site
557598000747	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
557598000748	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
557598000749	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
557598000750	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
557598000751	DNA binding residues [nucleotide binding]
557598000752	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
557598000753	FtsX-like permease family; Region: FtsX; cl15850
557598000754	Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960
557598000755	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000756	Walker A/P-loop; other site
557598000757	ATP binding site [chemical binding]; other site
557598000758	Q-loop/lid; other site
557598000759	ABC transporter signature motif; other site
557598000760	Walker B; other site
557598000761	D-loop; other site
557598000762	H-loop/switch region; other site
557598000763	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
557598000764	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
557598000765	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
557598000766	P loop; other site
557598000767	GTP binding site [chemical binding]; other site
557598000768	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
557598000769	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
557598000770	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
557598000771	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
557598000772	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
557598000773	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
557598000774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598000775	S-adenosylmethionine binding site [chemical binding]; other site
557598000776	hypothetical protein; Provisional; Region: PRK13795
557598000777	elongation factor Tu; Reviewed; Region: PRK00049
557598000778	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
557598000779	G1 box; other site
557598000780	GEF interaction site [polypeptide binding]; other site
557598000781	GTP/Mg2+ binding site [chemical binding]; other site
557598000782	Switch I region; other site
557598000783	G2 box; other site
557598000784	G3 box; other site
557598000785	Switch II region; other site
557598000786	G4 box; other site
557598000787	G5 box; other site
557598000788	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
557598000789	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
557598000790	Antibiotic Binding Site [chemical binding]; other site
557598000791	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
557598000792	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
557598000793	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
557598000794	putative homodimer interface [polypeptide binding]; other site
557598000795	KOW motif; Region: KOW; cl00354
557598000796	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
557598000797	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
557598000798	23S rRNA interface [nucleotide binding]; other site
557598000799	L7/L12 interface [polypeptide binding]; other site
557598000800	putative thiostrepton binding site; other site
557598000801	L25 interface [polypeptide binding]; other site
557598000802	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
557598000803	mRNA/rRNA interface [nucleotide binding]; other site
557598000804	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
557598000805	23S rRNA interface [nucleotide binding]; other site
557598000806	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
557598000807	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
557598000808	core dimer interface [polypeptide binding]; other site
557598000809	peripheral dimer interface [polypeptide binding]; other site
557598000810	L10 interface [polypeptide binding]; other site
557598000811	L11 interface [polypeptide binding]; other site
557598000812	putative EF-Tu interaction site [polypeptide binding]; other site
557598000813	putative EF-G interaction site [polypeptide binding]; other site
557598000814	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
557598000815	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
557598000816	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
557598000817	RPB12 interaction site [polypeptide binding]; other site
557598000818	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
557598000819	RPB11 interaction site [polypeptide binding]; other site
557598000820	RPB12 interaction site [polypeptide binding]; other site
557598000821	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
557598000822	RPB3 interaction site [polypeptide binding]; other site
557598000823	RPB1 interaction site [polypeptide binding]; other site
557598000824	RPB11 interaction site [polypeptide binding]; other site
557598000825	RPB10 interaction site [polypeptide binding]; other site
557598000826	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
557598000827	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
557598000828	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
557598000829	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
557598000830	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
557598000831	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
557598000832	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
557598000833	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
557598000834	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
557598000835	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
557598000836	DNA binding site [nucleotide binding]
557598000837	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
557598000838	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
557598000839	S17 interaction site [polypeptide binding]; other site
557598000840	S8 interaction site; other site
557598000841	16S rRNA interaction site [nucleotide binding]; other site
557598000842	streptomycin interaction site [chemical binding]; other site
557598000843	23S rRNA interaction site [nucleotide binding]; other site
557598000844	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
557598000845	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
557598000846	elongation factor G; Reviewed; Region: PRK00007
557598000847	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
557598000848	G1 box; other site
557598000849	putative GEF interaction site [polypeptide binding]; other site
557598000850	GTP/Mg2+ binding site [chemical binding]; other site
557598000851	Switch I region; other site
557598000852	G2 box; other site
557598000853	G3 box; other site
557598000854	Switch II region; other site
557598000855	G4 box; other site
557598000856	G5 box; other site
557598000857	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
557598000858	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
557598000859	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
557598000860	elongation factor Tu; Reviewed; Region: PRK00049
557598000861	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
557598000862	G1 box; other site
557598000863	GEF interaction site [polypeptide binding]; other site
557598000864	GTP/Mg2+ binding site [chemical binding]; other site
557598000865	Switch I region; other site
557598000866	G2 box; other site
557598000867	G3 box; other site
557598000868	Switch II region; other site
557598000869	G4 box; other site
557598000870	G5 box; other site
557598000871	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
557598000872	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
557598000873	Antibiotic Binding Site [chemical binding]; other site
557598000874	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
557598000875	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
557598000876	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
557598000877	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
557598000878	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
557598000879	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
557598000880	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
557598000881	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
557598000882	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
557598000883	putative translocon binding site; other site
557598000884	protein-rRNA interface [nucleotide binding]; other site
557598000885	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
557598000886	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
557598000887	G-X-X-G motif; other site
557598000888	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
557598000889	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
557598000890	23S rRNA interface [nucleotide binding]; other site
557598000891	5S rRNA interface [nucleotide binding]; other site
557598000892	putative antibiotic binding site [chemical binding]; other site
557598000893	L25 interface [polypeptide binding]; other site
557598000894	L27 interface [polypeptide binding]; other site
557598000895	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
557598000896	23S rRNA interface [nucleotide binding]; other site
557598000897	putative translocon interaction site; other site
557598000898	signal recognition particle (SRP54) interaction site; other site
557598000899	L23 interface [polypeptide binding]; other site
557598000900	trigger factor interaction site; other site
557598000901	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
557598000902	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
557598000903	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
557598000904	KOW motif; Region: KOW; cl00354
557598000905	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
557598000906	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
557598000907	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
557598000908	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
557598000909	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
557598000910	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
557598000911	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
557598000912	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
557598000913	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
557598000914	5S rRNA interface [nucleotide binding]; other site
557598000915	23S rRNA interface [nucleotide binding]; other site
557598000916	L5 interface [polypeptide binding]; other site
557598000917	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
557598000918	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
557598000919	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
557598000920	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
557598000921	23S rRNA binding site [nucleotide binding]; other site
557598000922	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
557598000923	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
557598000924	SecY translocase; Region: SecY; pfam00344
557598000925	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
557598000926	rRNA binding site [nucleotide binding]; other site
557598000927	predicted 30S ribosome binding site; other site
557598000928	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
557598000929	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
557598000930	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
557598000931	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
557598000932	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
557598000933	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
557598000934	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
557598000935	RNA binding surface [nucleotide binding]; other site
557598000936	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
557598000937	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
557598000938	alphaNTD homodimer interface [polypeptide binding]; other site
557598000939	alphaNTD - beta interaction site [polypeptide binding]; other site
557598000940	alphaNTD - beta' interaction site [polypeptide binding]; other site
557598000941	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
557598000942	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
557598000943	pteridine reductase; Provisional; Region: PRK09135
557598000944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598000945	NAD(P) binding site [chemical binding]; other site
557598000946	active site
557598000947	Uncharacterized conserved protein [Function unknown]; Region: COG1565
557598000948	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
557598000949	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
557598000950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
557598000951	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
557598000952	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
557598000953	[4Fe-4S] binding site [ion binding]; other site
557598000954	molybdopterin cofactor binding site; other site
557598000955	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
557598000956	molybdopterin cofactor binding site; other site
557598000957	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
557598000958	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
557598000959	SLBB domain; Region: SLBB; pfam10531
557598000960	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
557598000961	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
557598000962	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
557598000963	putative dimer interface [polypeptide binding]; other site
557598000964	MgtC family; Region: MgtC; pfam02308
557598000965	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
557598000966	putative active site [active]
557598000967	catalytic triad [active]
557598000968	putative dimer interface [polypeptide binding]; other site
557598000969	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
557598000970	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
557598000971	Transporter associated domain; Region: CorC_HlyC; cl08393
557598000972	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
557598000973	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
557598000974	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598000975	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
557598000976	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
557598000977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598000978	FeS/SAM binding site; other site
557598000979	TRAM domain; Region: TRAM; cl01282
557598000980	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598000981	Helix-turn-helix domains; Region: HTH; cl00088
557598000982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
557598000983	dimerization interface [polypeptide binding]; other site
557598000984	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
557598000985	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
557598000986	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
557598000987	dimer interface [polypeptide binding]; other site
557598000988	active site
557598000989	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
557598000990	substrate binding site [chemical binding]; other site
557598000991	catalytic residue [active]
557598000992	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598000993	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598000994	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598000995	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
557598000996	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598000997	active site
557598000998	SCP-2 sterol transfer family; Region: SCP2; cl01225
557598000999	Peptidase family U32; Region: Peptidase_U32; cl03113
557598001000	Peptidase family U32; Region: Peptidase_U32; cl03113
557598001001	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
557598001002	DNA binding residues [nucleotide binding]
557598001003	B12 binding domain; Region: B12-binding_2; cl03653
557598001004	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
557598001005	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
557598001006	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
557598001007	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
557598001008	putative active site [active]
557598001009	catalytic residue [active]
557598001010	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
557598001011	5S rRNA interface [nucleotide binding]; other site
557598001012	CTC domain interface [polypeptide binding]; other site
557598001013	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
557598001014	L16 interface [polypeptide binding]; other site
557598001015	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
557598001016	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
557598001017	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598001018	active site
557598001019	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
557598001020	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
557598001021	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
557598001022	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
557598001023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
557598001024	binding surface
557598001025	TPR motif; other site
557598001026	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
557598001027	TPR motif; other site
557598001028	binding surface
557598001029	TPR repeat; Region: TPR_11; pfam13414
557598001030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
557598001031	binding surface
557598001032	TPR motif; other site
557598001033	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
557598001034	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
557598001035	DNA binding site [nucleotide binding]
557598001036	catalytic residue [active]
557598001037	H2TH interface [polypeptide binding]; other site
557598001038	putative catalytic residues [active]
557598001039	turnover-facilitating residue; other site
557598001040	intercalation triad [nucleotide binding]; other site
557598001041	8OG recognition residue [nucleotide binding]; other site
557598001042	putative reading head residues; other site
557598001043	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
557598001044	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
557598001045	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
557598001046	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
557598001047	active site
557598001048	metal binding site [ion binding]; metal-binding site
557598001049	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
557598001050	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598001051	Family description; Region: UvrD_C_2; cl15862
557598001052	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
557598001053	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
557598001054	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
557598001055	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
557598001056	nudix motif; other site
557598001057	UbiA prenyltransferase family; Region: UbiA; cl00337
557598001058	UTRA domain; Region: UTRA; cl01230
557598001059	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
557598001060	catalytic core [active]
557598001061	sensor protein QseC; Provisional; Region: PRK10337
557598001062	sensor protein BasS/PmrB; Provisional; Region: PRK10755
557598001063	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598001064	dimer interface [polypeptide binding]; other site
557598001065	phosphorylation site [posttranslational modification]
557598001066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001067	ATP binding site [chemical binding]; other site
557598001068	G-X-G motif; other site
557598001069	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
557598001070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001071	active site
557598001072	phosphorylation site [posttranslational modification]
557598001073	intermolecular recognition site; other site
557598001074	dimerization interface [polypeptide binding]; other site
557598001075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598001076	DNA binding site [nucleotide binding]
557598001077	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
557598001078	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598001079	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
557598001080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598001081	dimer interface [polypeptide binding]; other site
557598001082	conserved gate region; other site
557598001083	putative PBP binding loops; other site
557598001084	ABC-ATPase subunit interface; other site
557598001085	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598001086	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
557598001087	sulfate transport protein; Provisional; Region: cysT; CHL00187
557598001088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598001089	dimer interface [polypeptide binding]; other site
557598001090	conserved gate region; other site
557598001091	putative PBP binding loops; other site
557598001092	ABC-ATPase subunit interface; other site
557598001093	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
557598001094	Helix-turn-helix domains; Region: HTH; cl00088
557598001095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598001096	dimerization interface [polypeptide binding]; other site
557598001097	DsrE/DsrF-like family; Region: DrsE; cl00672
557598001098	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
557598001099	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
557598001100	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
557598001101	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
557598001102	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
557598001103	active site
557598001104	dimerization interface [polypeptide binding]; other site
557598001105	GTP-binding protein YchF; Reviewed; Region: PRK09601
557598001106	YchF GTPase; Region: YchF; cd01900
557598001107	G1 box; other site
557598001108	GTP/Mg2+ binding site [chemical binding]; other site
557598001109	Switch I region; other site
557598001110	G2 box; other site
557598001111	Switch II region; other site
557598001112	G3 box; other site
557598001113	G4 box; other site
557598001114	G5 box; other site
557598001115	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
557598001116	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598001117	metal binding site [ion binding]; metal-binding site
557598001118	active site
557598001119	I-site; other site
557598001120	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
557598001121	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
557598001122	alanine racemase; Reviewed; Region: alr; PRK00053
557598001123	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
557598001124	active site
557598001125	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
557598001126	substrate binding site [chemical binding]; other site
557598001127	catalytic residues [active]
557598001128	dimer interface [polypeptide binding]; other site
557598001129	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
557598001130	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598001131	FeS/SAM binding site; other site
557598001132	HemN C-terminal domain; Region: HemN_C; pfam06969
557598001133	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
557598001134	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
557598001135	ligand binding site [chemical binding]; other site
557598001136	flexible hinge region; other site
557598001137	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
557598001138	putative switch regulator; other site
557598001139	non-specific DNA interactions [nucleotide binding]; other site
557598001140	DNA binding site [nucleotide binding]
557598001141	sequence specific DNA binding site [nucleotide binding]; other site
557598001142	putative cAMP binding site [chemical binding]; other site
557598001143	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
557598001144	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
557598001145	DNA binding residues [nucleotide binding]
557598001146	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
557598001147	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
557598001148	putative peptidoglycan binding site; other site
557598001149	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
557598001150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598001151	S-adenosylmethionine binding site [chemical binding]; other site
557598001152	Survival protein SurE; Region: SurE; cl00448
557598001153	Quinolinate synthetase A protein; Region: NadA; cl00420
557598001154	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
557598001155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001156	CoA-ligase; Region: Ligase_CoA; cl02894
557598001157	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598001158	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
557598001159	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598001160	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
557598001161	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
557598001162	RimM N-terminal domain; Region: RimM; pfam01782
557598001163	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
557598001164	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
557598001165	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
557598001166	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
557598001167	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
557598001168	DNA binding site [nucleotide binding]
557598001169	active site
557598001170	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
557598001171	Clp amino terminal domain; Region: Clp_N; pfam02861
557598001172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598001173	Walker A motif; other site
557598001174	ATP binding site [chemical binding]; other site
557598001175	Walker B motif; other site
557598001176	arginine finger; other site
557598001177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598001178	Walker A motif; other site
557598001179	ATP binding site [chemical binding]; other site
557598001180	Walker B motif; other site
557598001181	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
557598001182	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
557598001183	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
557598001184	DNA-binding site [nucleotide binding]; DNA binding site
557598001185	RNA-binding motif; other site
557598001186	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
557598001187	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891
557598001188	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
557598001189	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
557598001190	pseudouridine synthase; Region: TIGR00093
557598001191	active site
557598001192	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
557598001193	MutS domain I; Region: MutS_I; pfam01624
557598001194	MutS domain II; Region: MutS_II; pfam05188
557598001195	MutS family domain IV; Region: MutS_IV; pfam05190
557598001196	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598001197	Walker A/P-loop; other site
557598001198	ATP binding site [chemical binding]; other site
557598001199	Q-loop/lid; other site
557598001200	ABC transporter signature motif; other site
557598001201	Walker B; other site
557598001202	D-loop; other site
557598001203	H-loop/switch region; other site
557598001204	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598001205	active site
557598001206	DNA binding site [nucleotide binding]
557598001207	Int/Topo IB signature motif; other site
557598001208	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
557598001209	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
557598001210	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
557598001211	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598001212	non-specific DNA binding site [nucleotide binding]; other site
557598001213	salt bridge; other site
557598001214	sequence-specific DNA binding site [nucleotide binding]; other site
557598001215	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
557598001216	TIR domain; Region: TIR_2; cl15770
557598001217	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
557598001218	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598001219	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
557598001220	Phage-related tail protein [Function unknown]; Region: COG5283
557598001221	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
557598001222	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
557598001223	Phage tail tube protein FII; Region: Phage_tube; cl01390
557598001224	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
557598001225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001226	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
557598001227	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598001228	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
557598001229	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
557598001230	Baseplate J-like protein; Region: Baseplate_J; cl01294
557598001231	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
557598001232	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
557598001233	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
557598001234	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
557598001235	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
557598001236	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
557598001237	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
557598001238	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
557598001239	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
557598001240	Protein of unknown function (DUF754); Region: DUF754; pfam05449
557598001241	Phage Tail Protein X; Region: Phage_tail_X; cl02088
557598001242	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
557598001243	terminase endonuclease subunit; Provisional; Region: M; PHA02537
557598001244	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
557598001245	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
557598001246	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
557598001247	terminase ATPase subunit; Provisional; Region: P; PHA02535
557598001248	Helix-turn-helix domains; Region: HTH; cl00088
557598001249	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
557598001250	Phage-related protein [Function unknown]; Region: COG4695; cl01923
557598001251	phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540
557598001252	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
557598001253	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
557598001254	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
557598001255	catalytic residues [active]
557598001256	dimer interface [polypeptide binding]; other site
557598001257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598001258	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001259	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
557598001260	NAD(P) binding site [chemical binding]; other site
557598001261	active site
557598001262	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
557598001263	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
557598001264	catalytic loop [active]
557598001265	iron binding site [ion binding]; other site
557598001266	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
557598001267	FAD binding pocket [chemical binding]; other site
557598001268	FAD binding motif [chemical binding]; other site
557598001269	phosphate binding motif [ion binding]; other site
557598001270	beta-alpha-beta structure motif; other site
557598001271	NAD binding pocket [chemical binding]; other site
557598001272	Spore germination protein; Region: Spore_permease; cl15802
557598001273	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
557598001274	eyelet of channel; other site
557598001275	trimer interface [polypeptide binding]; other site
557598001276	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
557598001277	Amidinotransferase; Region: Amidinotransf; cl12043
557598001278	lysine transporter; Provisional; Region: PRK10836
557598001279	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
557598001280	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598001281	active site
557598001282	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
557598001283	Clp amino terminal domain; Region: Clp_N; pfam02861
557598001284	Clp amino terminal domain; Region: Clp_N; pfam02861
557598001285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598001286	Walker A motif; other site
557598001287	ATP binding site [chemical binding]; other site
557598001288	Walker B motif; other site
557598001289	arginine finger; other site
557598001290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598001291	Walker A motif; other site
557598001292	ATP binding site [chemical binding]; other site
557598001293	Walker B motif; other site
557598001294	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
557598001295	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
557598001296	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
557598001297	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
557598001298	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
557598001299	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
557598001300	Rod binding protein; Region: Rod-binding; cl01626
557598001301	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
557598001302	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
557598001303	Flagellar L-ring protein; Region: FlgH; cl00905
557598001304	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
557598001305	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
557598001306	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
557598001307	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
557598001308	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
557598001309	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
557598001310	flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637
557598001311	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
557598001312	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
557598001313	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
557598001314	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
557598001315	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
557598001316	FlgD Ig-like domain; Region: FlgD_ig; cl15790
557598001317	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
557598001318	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
557598001319	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
557598001320	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
557598001321	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
557598001322	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
557598001323	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
557598001324	Walker A/P-loop; other site
557598001325	ATP binding site [chemical binding]; other site
557598001326	Q-loop/lid; other site
557598001327	ABC transporter signature motif; other site
557598001328	Walker B; other site
557598001329	D-loop; other site
557598001330	H-loop/switch region; other site
557598001331	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
557598001332	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
557598001333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598001334	dimer interface [polypeptide binding]; other site
557598001335	conserved gate region; other site
557598001336	putative PBP binding loops; other site
557598001337	ABC-ATPase subunit interface; other site
557598001338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
557598001339	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
557598001340	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
557598001341	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598001342	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598001343	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
557598001344	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
557598001345	DNA binding residues [nucleotide binding]
557598001346	dimer interface [polypeptide binding]; other site
557598001347	putative metal binding site [ion binding]; other site
557598001348	putative protease; Provisional; Region: PRK15452
557598001349	Peptidase family U32; Region: Peptidase_U32; cl03113
557598001350	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
557598001351	dinuclear metal binding motif [ion binding]; other site
557598001352	FliW protein; Region: FliW; cl00740
557598001353	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
557598001354	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
557598001355	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
557598001356	catalytic site [active]
557598001357	G-X2-G-X-G-K; other site
557598001358	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
557598001359	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
557598001360	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
557598001361	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
557598001362	synthetase active site [active]
557598001363	NTP binding site [chemical binding]; other site
557598001364	metal binding site [ion binding]; metal-binding site
557598001365	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
557598001366	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
557598001367	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
557598001368	thiS-thiF/thiG interaction site; other site
557598001369	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
557598001370	ThiS interaction site; other site
557598001371	putative active site [active]
557598001372	tetramer interface [polypeptide binding]; other site
557598001373	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
557598001374	GatB domain; Region: GatB_Yqey; cl11497
557598001375	DNA primase, catalytic core; Region: dnaG; TIGR01391
557598001376	CHC2 zinc finger; Region: zf-CHC2; cl15369
557598001377	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
557598001378	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
557598001379	active site
557598001380	metal binding site [ion binding]; metal-binding site
557598001381	interdomain interaction site; other site
557598001382	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
557598001383	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
557598001384	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
557598001385	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
557598001386	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
557598001387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
557598001388	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
557598001389	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
557598001390	DNA binding residues [nucleotide binding]
557598001391	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
557598001392	MatE; Region: MatE; cl10513
557598001393	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598001394	Helix-turn-helix domains; Region: HTH; cl00088
557598001395	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
557598001396	putative effector binding pocket; other site
557598001397	dimerization interface [polypeptide binding]; other site
557598001398	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
557598001399	Helix-turn-helix domains; Region: HTH; cl00088
557598001400	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
557598001401	putative dimerization interface [polypeptide binding]; other site
557598001402	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
557598001403	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
557598001404	THF binding site; other site
557598001405	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
557598001406	substrate binding site [chemical binding]; other site
557598001407	THF binding site; other site
557598001408	zinc-binding site [ion binding]; other site
557598001409	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
557598001410	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598001411	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
557598001412	dimer interface [polypeptide binding]; other site
557598001413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
557598001414	metal binding site [ion binding]; metal-binding site
557598001415	Domain of unknown function (DUF202); Region: DUF202; cl09954
557598001416	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
557598001417	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
557598001418	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598001419	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001420	dimer interface [polypeptide binding]; other site
557598001421	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598001422	putative CheW interface [polypeptide binding]; other site
557598001423	heat shock protein 90; Provisional; Region: PRK05218
557598001424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001425	ATP binding site [chemical binding]; other site
557598001426	Mg2+ binding site [ion binding]; other site
557598001427	G-X-G motif; other site
557598001428	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
557598001429	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
557598001430	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598001431	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
557598001432	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598001433	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
557598001434	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598001435	Ligand Binding Site [chemical binding]; other site
557598001436	BCCT family transporter; Region: BCCT; cl00569
557598001437	Creatinine amidohydrolase; Region: Creatininase; cl00618
557598001438	Predicted permeases [General function prediction only]; Region: RarD; COG2962
557598001439	EamA-like transporter family; Region: EamA; cl01037
557598001440	EamA-like transporter family; Region: EamA; cl01037
557598001441	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598001442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598001443	fumarate hydratase; Reviewed; Region: fumC; PRK00485
557598001444	Class II fumarases; Region: Fumarase_classII; cd01362
557598001445	active site
557598001446	tetramer interface [polypeptide binding]; other site
557598001447	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
557598001448	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
557598001449	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
557598001450	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
557598001451	N-terminal plug; other site
557598001452	ligand-binding site [chemical binding]; other site
557598001453	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
557598001454	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
557598001455	Gram-negative bacterial tonB protein; Region: TonB; cl10048
557598001456	uracil-xanthine permease; Region: ncs2; TIGR00801
557598001457	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
557598001458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598001459	active site
557598001460	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
557598001461	putative GSH binding site [chemical binding]; other site
557598001462	catalytic residues [active]
557598001463	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
557598001464	putative ion selectivity filter; other site
557598001465	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
557598001466	putative pore gating glutamate residue; other site
557598001467	putative H+/Cl- coupling transport residue; other site
557598001468	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
557598001469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598001470	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
557598001471	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
557598001472	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
557598001473	active site
557598001474	substrate binding site [chemical binding]; other site
557598001475	cosubstrate binding site; other site
557598001476	catalytic site [active]
557598001477	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
557598001478	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
557598001479	dimerization interface [polypeptide binding]; other site
557598001480	putative ATP binding site [chemical binding]; other site
557598001481	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
557598001482	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
557598001483	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598001484	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
557598001485	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598001486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
557598001487	SCP-2 sterol transfer family; Region: SCP2; cl01225
557598001488	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
557598001489	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598001490	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598001491	active site
557598001492	ATP binding site [chemical binding]; other site
557598001493	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
557598001494	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598001495	FeS/SAM binding site; other site
557598001496	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
557598001497	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
557598001498	active site clefts [active]
557598001499	zinc binding site [ion binding]; other site
557598001500	dimer interface [polypeptide binding]; other site
557598001501	Cache domain; Region: Cache_2; cl07034
557598001502	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001503	dimer interface [polypeptide binding]; other site
557598001504	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598001505	putative CheW interface [polypeptide binding]; other site
557598001506	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
557598001507	Surface antigen; Region: Bac_surface_Ag; cl03097
557598001508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
557598001509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
557598001510	Family of unknown function (DUF490); Region: DUF490; pfam04357
557598001511	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
557598001512	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
557598001513	Walker A/P-loop; other site
557598001514	ATP binding site [chemical binding]; other site
557598001515	Q-loop/lid; other site
557598001516	ABC transporter signature motif; other site
557598001517	Walker B; other site
557598001518	D-loop; other site
557598001519	H-loop/switch region; other site
557598001520	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
557598001521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598001522	dimer interface [polypeptide binding]; other site
557598001523	conserved gate region; other site
557598001524	putative PBP binding loops; other site
557598001525	ABC-ATPase subunit interface; other site
557598001526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598001527	dimer interface [polypeptide binding]; other site
557598001528	conserved gate region; other site
557598001529	putative PBP binding loops; other site
557598001530	ABC-ATPase subunit interface; other site
557598001531	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598001532	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
557598001533	substrate binding site [chemical binding]; other site
557598001534	dimer interface [polypeptide binding]; other site
557598001535	catalytic triad [active]
557598001536	Preprotein translocase SecG subunit; Region: SecG; cl09123
557598001537	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
557598001538	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
557598001539	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
557598001540	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
557598001541	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
557598001542	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
557598001543	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
557598001544	putative dimer interface [polypeptide binding]; other site
557598001545	[2Fe-2S] cluster binding site [ion binding]; other site
557598001546	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
557598001547	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
557598001548	SLBB domain; Region: SLBB; pfam10531
557598001549	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
557598001550	NADH dehydrogenase subunit G; Validated; Region: PRK09129
557598001551	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
557598001552	catalytic loop [active]
557598001553	iron binding site [ion binding]; other site
557598001554	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
557598001555	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
557598001556	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
557598001557	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
557598001558	NADH dehydrogenase; Region: NADHdh; cl00469
557598001559	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
557598001560	4Fe-4S binding domain; Region: Fer4; cl02805
557598001561	4Fe-4S binding domain; Region: Fer4; cl02805
557598001562	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
557598001563	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
557598001564	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
557598001565	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
557598001566	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
557598001567	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
557598001568	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
557598001569	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
557598001570	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
557598001571	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
557598001572	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
557598001573	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
557598001574	FAD binding site [chemical binding]; other site
557598001575	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
557598001576	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
557598001577	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
557598001578	CTP synthetase; Validated; Region: pyrG; PRK05380
557598001579	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
557598001580	Catalytic site [active]
557598001581	active site
557598001582	UTP binding site [chemical binding]; other site
557598001583	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
557598001584	active site
557598001585	putative oxyanion hole; other site
557598001586	catalytic triad [active]
557598001587	NeuB family; Region: NeuB; cl00496
557598001588	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
557598001589	enolase; Provisional; Region: eno; PRK00077
557598001590	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
557598001591	dimer interface [polypeptide binding]; other site
557598001592	metal binding site [ion binding]; metal-binding site
557598001593	substrate binding pocket [chemical binding]; other site
557598001594	Septum formation initiator; Region: DivIC; cl11433
557598001595	diguanylate cyclase; Provisional; Region: PRK09894
557598001596	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598001597	metal binding site [ion binding]; metal-binding site
557598001598	active site
557598001599	I-site; other site
557598001600	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
557598001601	Fe-S cluster binding site [ion binding]; other site
557598001602	active site
557598001603	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
557598001604	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598001605	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
557598001606	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
557598001607	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
557598001608	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
557598001609	putative binding surface; other site
557598001610	active site
557598001611	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
557598001612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001613	ATP binding site [chemical binding]; other site
557598001614	Mg2+ binding site [ion binding]; other site
557598001615	G-X-G motif; other site
557598001616	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
557598001617	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
557598001618	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
557598001619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001620	active site
557598001621	phosphorylation site [posttranslational modification]
557598001622	intermolecular recognition site; other site
557598001623	dimerization interface [polypeptide binding]; other site
557598001624	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598001625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001626	active site
557598001627	phosphorylation site [posttranslational modification]
557598001628	intermolecular recognition site; other site
557598001629	dimerization interface [polypeptide binding]; other site
557598001630	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598001631	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
557598001632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001633	active site
557598001634	phosphorylation site [posttranslational modification]
557598001635	intermolecular recognition site; other site
557598001636	dimerization interface [polypeptide binding]; other site
557598001637	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
557598001638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598001639	phosphorylation site [posttranslational modification]
557598001640	dimer interface [polypeptide binding]; other site
557598001641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001642	ATP binding site [chemical binding]; other site
557598001643	Mg2+ binding site [ion binding]; other site
557598001644	G-X-G motif; other site
557598001645	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001646	dimer interface [polypeptide binding]; other site
557598001647	putative CheW interface [polypeptide binding]; other site
557598001648	Response regulator receiver domain; Region: Response_reg; pfam00072
557598001649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001650	active site
557598001651	phosphorylation site [posttranslational modification]
557598001652	intermolecular recognition site; other site
557598001653	dimerization interface [polypeptide binding]; other site
557598001654	chemotaxis protein CheA; Provisional; Region: PRK10547
557598001655	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
557598001656	putative binding surface; other site
557598001657	active site
557598001658	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
557598001659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001660	ATP binding site [chemical binding]; other site
557598001661	Mg2+ binding site [ion binding]; other site
557598001662	G-X-G motif; other site
557598001663	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
557598001664	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598001665	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
557598001666	PAS domain; Region: PAS_9; pfam13426
557598001667	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001668	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598001669	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001670	dimer interface [polypeptide binding]; other site
557598001671	putative CheW interface [polypeptide binding]; other site
557598001672	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
557598001673	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
557598001674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001675	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
557598001676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598001677	active site
557598001678	phosphorylation site [posttranslational modification]
557598001679	intermolecular recognition site; other site
557598001680	dimerization interface [polypeptide binding]; other site
557598001681	CheB methylesterase; Region: CheB_methylest; pfam01339
557598001682	CheD chemotactic sensory transduction; Region: CheD; cl00810
557598001683	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
557598001684	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
557598001685	dimer interface [polypeptide binding]; other site
557598001686	active site
557598001687	Phosphopantetheine attachment site; Region: PP-binding; cl09936
557598001688	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
557598001689	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
557598001690	NAD(P) binding site [chemical binding]; other site
557598001691	homotetramer interface [polypeptide binding]; other site
557598001692	homodimer interface [polypeptide binding]; other site
557598001693	active site
557598001694	Acyl transferase domain; Region: Acyl_transf_1; cl08282
557598001695	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
557598001696	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
557598001697	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
557598001698	dimer interface [polypeptide binding]; other site
557598001699	active site
557598001700	CoA binding pocket [chemical binding]; other site
557598001701	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
557598001702	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
557598001703	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
557598001704	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
557598001705	active site
557598001706	dimer interface [polypeptide binding]; other site
557598001707	Predicted methyltransferases [General function prediction only]; Region: COG0313
557598001708	hypothetical protein; Validated; Region: PRK09070
557598001709	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
557598001710	chorismate binding enzyme; Region: Chorismate_bind; cl10555
557598001711	S-adenosylmethionine synthetase; Validated; Region: PRK05250
557598001712	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
557598001713	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
557598001714	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
557598001715	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
557598001716	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
557598001717	putative acyl-acceptor binding pocket; other site
557598001718	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
557598001719	putative acyl-acceptor binding pocket; other site
557598001720	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
557598001721	C-terminal domain interface [polypeptide binding]; other site
557598001722	GSH binding site (G-site) [chemical binding]; other site
557598001723	dimer interface [polypeptide binding]; other site
557598001724	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
557598001725	N-terminal domain interface [polypeptide binding]; other site
557598001726	dimer interface [polypeptide binding]; other site
557598001727	substrate binding pocket (H-site) [chemical binding]; other site
557598001728	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
557598001729	FlgN protein; Region: FlgN; cl09176
557598001730	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
557598001731	SAF domain; Region: SAF; cl00555
557598001732	SAF-like; Region: SAF_2; pfam13144
557598001733	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
557598001734	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
557598001735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598001736	catalytic residue [active]
557598001737	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
557598001738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
557598001739	Coenzyme A binding pocket [chemical binding]; other site
557598001740	homoserine dehydrogenase; Provisional; Region: PRK06349
557598001741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001742	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
557598001743	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
557598001744	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598001745	Ligand Binding Site [chemical binding]; other site
557598001746	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
557598001747	catalytic residues [active]
557598001748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598001749	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598001750	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
557598001751	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
557598001752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598001753	S-adenosylmethionine binding site [chemical binding]; other site
557598001754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001755	Protein of unknown function (DUF971); Region: DUF971; cl01414
557598001756	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
557598001757	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
557598001758	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
557598001759	trimer interface [polypeptide binding]; other site
557598001760	active site
557598001761	dimer interface [polypeptide binding]; other site
557598001762	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
557598001763	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
557598001764	carboxyltransferase (CT) interaction site; other site
557598001765	biotinylation site [posttranslational modification]; other site
557598001766	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
557598001767	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
557598001768	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598001769	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
557598001770	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
557598001771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001772	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
557598001773	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
557598001774	Nitrate and nitrite sensing; Region: NIT; pfam08376
557598001775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598001776	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598001777	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001778	dimer interface [polypeptide binding]; other site
557598001779	putative CheW interface [polypeptide binding]; other site
557598001780	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
557598001781	putative active site [active]
557598001782	Ap4A binding site [chemical binding]; other site
557598001783	nudix motif; other site
557598001784	putative metal binding site [ion binding]; other site
557598001785	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
557598001786	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
557598001787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598001788	ATP binding site [chemical binding]; other site
557598001789	Mg2+ binding site [ion binding]; other site
557598001790	G-X-G motif; other site
557598001791	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
557598001792	anchoring element; other site
557598001793	dimer interface [polypeptide binding]; other site
557598001794	ATP binding site [chemical binding]; other site
557598001795	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
557598001796	active site
557598001797	metal binding site [ion binding]; metal-binding site
557598001798	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
557598001799	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
557598001800	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
557598001801	active site
557598001802	HIGH motif; other site
557598001803	dimer interface [polypeptide binding]; other site
557598001804	KMSKS motif; other site
557598001805	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
557598001806	Helix-turn-helix domains; Region: HTH; cl00088
557598001807	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
557598001808	substrate binding site [chemical binding]; other site
557598001809	dimerization interface [polypeptide binding]; other site
557598001810	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
557598001811	Active Sites [active]
557598001812	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
557598001813	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
557598001814	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
557598001815	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
557598001816	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
557598001817	ligand binding site [chemical binding]; other site
557598001818	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
557598001819	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
557598001820	active site
557598001821	Riboflavin kinase; Region: Flavokinase; cl03312
557598001822	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
557598001823	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598001824	active site
557598001825	HIGH motif; other site
557598001826	nucleotide binding site [chemical binding]; other site
557598001827	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
557598001828	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
557598001829	active site
557598001830	KMSKS motif; other site
557598001831	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
557598001832	tRNA binding surface [nucleotide binding]; other site
557598001833	anticodon binding site; other site
557598001834	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
557598001835	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
557598001836	lipoprotein signal peptidase; Provisional; Region: PRK14787
557598001837	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
557598001838	LytB protein; Region: LYTB; cl00507
557598001839	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598001840	dimer interface [polypeptide binding]; other site
557598001841	putative CheW interface [polypeptide binding]; other site
557598001842	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
557598001843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598001844	PAS domain; Region: PAS_9; pfam13426
557598001845	putative active site [active]
557598001846	heme pocket [chemical binding]; other site
557598001847	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
557598001848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001849	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598001850	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
557598001851	apolar tunnel; other site
557598001852	heme binding site [chemical binding]; other site
557598001853	dimerization interface [polypeptide binding]; other site
557598001854	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
557598001855	homooctamer interface [polypeptide binding]; other site
557598001856	active site
557598001857	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
557598001858	Protein of unknown function (DUF330); Region: DUF330; cl01135
557598001859	mce related protein; Region: MCE; pfam02470
557598001860	paraquat-inducible protein B; Provisional; Region: PRK10807
557598001861	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598001862	ABC transporter; Region: ABC_tran; pfam00005
557598001863	Q-loop/lid; other site
557598001864	ABC transporter signature motif; other site
557598001865	Walker B; other site
557598001866	D-loop; other site
557598001867	H-loop/switch region; other site
557598001868	Permease; Region: Permease; cl00510
557598001869	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
557598001870	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
557598001871	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598001872	ATP binding site [chemical binding]; other site
557598001873	putative Mg++ binding site [ion binding]; other site
557598001874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598001875	nucleotide binding region [chemical binding]; other site
557598001876	ATP-binding site [chemical binding]; other site
557598001877	TRCF domain; Region: TRCF; cl04088
557598001878	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
557598001879	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
557598001880	Protein of unknown function, DUF; Region: DUF411; cl01142
557598001881	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
557598001882	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598001883	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598001884	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598001885	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
557598001886	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
557598001887	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
557598001888	PAS domain S-box; Region: sensory_box; TIGR00229
557598001889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598001890	putative active site [active]
557598001891	heme pocket [chemical binding]; other site
557598001892	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598001893	PAS domain; Region: PAS_9; pfam13426
557598001894	putative active site [active]
557598001895	heme pocket [chemical binding]; other site
557598001896	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598001897	metal binding site [ion binding]; metal-binding site
557598001898	active site
557598001899	I-site; other site
557598001900	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598001901	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964
557598001902	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
557598001903	active site
557598001904	(T/H)XGH motif; other site
557598001905	hypothetical protein; Provisional; Region: PRK08999
557598001906	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
557598001907	active site
557598001908	8-oxo-dGMP binding site [chemical binding]; other site
557598001909	nudix motif; other site
557598001910	metal binding site [ion binding]; metal-binding site
557598001911	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
557598001912	active site
557598001913	thiamine phosphate binding site [chemical binding]; other site
557598001914	pyrophosphate binding site [ion binding]; other site
557598001915	Ferredoxin [Energy production and conversion]; Region: COG1146
557598001916	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
557598001917	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598001918	active site
557598001919	HIGH motif; other site
557598001920	nucleotide binding site [chemical binding]; other site
557598001921	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598001922	active site
557598001923	KMSKS motif; other site
557598001924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598001925	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
557598001926	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
557598001927	Competence protein; Region: Competence; cl00471
557598001928	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
557598001929	Predicted permease [General function prediction only]; Region: COG2056
557598001930	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
557598001931	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
557598001932	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
557598001933	malate synthase A; Region: malate_syn_A; TIGR01344
557598001934	active site
557598001935	LysR family transcriptional regulator; Provisional; Region: PRK14997
557598001936	Helix-turn-helix domains; Region: HTH; cl00088
557598001937	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
557598001938	putative effector binding pocket; other site
557598001939	dimerization interface [polypeptide binding]; other site
557598001940	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
557598001941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598001942	PAS fold; Region: PAS_3; pfam08447
557598001943	putative active site [active]
557598001944	heme pocket [chemical binding]; other site
557598001945	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598001946	PAS fold; Region: PAS_7; pfam12860
557598001947	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598001948	metal binding site [ion binding]; metal-binding site
557598001949	active site
557598001950	I-site; other site
557598001951	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
557598001952	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
557598001953	Polyphosphate kinase C-terminal domain; Region: PP_kinase_C; pfam13090
557598001954	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
557598001955	putative active site [active]
557598001956	catalytic site [active]
557598001957	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
557598001958	putative domain interface [polypeptide binding]; other site
557598001959	putative active site [active]
557598001960	catalytic site [active]
557598001961	Protein of unknown function (DUF456); Region: DUF456; cl01069
557598001962	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
557598001963	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
557598001964	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
557598001965	oligomerisation interface [polypeptide binding]; other site
557598001966	mobile loop; other site
557598001967	roof hairpin; other site
557598001968	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
557598001969	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
557598001970	ring oligomerisation interface [polypeptide binding]; other site
557598001971	ATP/Mg binding site [chemical binding]; other site
557598001972	stacking interactions; other site
557598001973	hinge regions; other site
557598001974	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
557598001975	trimer interface [polypeptide binding]; other site
557598001976	eyelet of channel; other site
557598001977	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
557598001978	Domain of unknown function DUF21; Region: DUF21; pfam01595
557598001979	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
557598001980	Transporter associated domain; Region: CorC_HlyC; cl08393
557598001981	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
557598001982	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
557598001983	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
557598001984	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
557598001985	CoA-binding site [chemical binding]; other site
557598001986	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
557598001987	Domain of unknown function (DUF329); Region: DUF329; cl01144
557598001988	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
557598001989	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
557598001990	peptide binding site [polypeptide binding]; other site
557598001991	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
557598001992	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
557598001993	putative active site [active]
557598001994	catalytic site [active]
557598001995	putative metal binding site [ion binding]; other site
557598001996	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
557598001997	FAD binding domain; Region: FAD_binding_4; pfam01565
557598001998	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
557598001999	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
557598002000	NAD(P) binding site [chemical binding]; other site
557598002001	catalytic residues [active]
557598002002	putative glutathione S-transferase; Provisional; Region: PRK10357
557598002003	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
557598002004	putative C-terminal domain interface [polypeptide binding]; other site
557598002005	putative GSH binding site (G-site) [chemical binding]; other site
557598002006	putative dimer interface [polypeptide binding]; other site
557598002007	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
557598002008	dimer interface [polypeptide binding]; other site
557598002009	N-terminal domain interface [polypeptide binding]; other site
557598002010	putative substrate binding pocket (H-site) [chemical binding]; other site
557598002011	Protein of unknown function (DUF541); Region: SIMPL; cl01077
557598002012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598002013	PAS fold; Region: PAS_4; pfam08448
557598002014	PAS domain S-box; Region: sensory_box; TIGR00229
557598002015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598002016	putative active site [active]
557598002017	heme pocket [chemical binding]; other site
557598002018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598002019	PAS domain; Region: PAS_9; pfam13426
557598002020	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002021	metal binding site [ion binding]; metal-binding site
557598002022	active site
557598002023	I-site; other site
557598002024	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598002025	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
557598002026	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
557598002027	oligomerization interface [polypeptide binding]; other site
557598002028	active site
557598002029	NAD+ binding site [chemical binding]; other site
557598002030	carbon starvation protein A; Provisional; Region: PRK15015
557598002031	Carbon starvation protein CstA; Region: CstA; pfam02554
557598002032	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
557598002033	Protein of unknown function (DUF466); Region: DUF466; cl01082
557598002034	succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538
557598002035	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598002036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598002037	homodimer interface [polypeptide binding]; other site
557598002038	catalytic residue [active]
557598002039	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
557598002040	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
557598002041	trimer interface [polypeptide binding]; other site
557598002042	active site
557598002043	substrate binding site [chemical binding]; other site
557598002044	CoA binding site [chemical binding]; other site
557598002045	Predicted ATPase [General function prediction only]; Region: COG1485
557598002046	Sporulation related domain; Region: SPOR; cl10051
557598002047	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
557598002048	active site
557598002049	multimer interface [polypeptide binding]; other site
557598002050	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
557598002051	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598002052	FeS/SAM binding site; other site
557598002053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
557598002054	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
557598002055	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
557598002056	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
557598002057	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
557598002058	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
557598002059	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
557598002060	dimer interface [polypeptide binding]; other site
557598002061	motif 1; other site
557598002062	active site
557598002063	motif 2; other site
557598002064	motif 3; other site
557598002065	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
557598002066	anticodon binding site; other site
557598002067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
557598002068	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
557598002069	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
557598002070	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
557598002071	Trp docking motif [polypeptide binding]; other site
557598002072	active site
557598002073	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
557598002074	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
557598002075	Switch II region; other site
557598002076	G3 box; other site
557598002077	GTP/Mg2+ binding site [chemical binding]; other site
557598002078	G4 box; other site
557598002079	G5 box; other site
557598002080	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
557598002081	G1 box; other site
557598002082	GTP/Mg2+ binding site [chemical binding]; other site
557598002083	Switch I region; other site
557598002084	G2 box; other site
557598002085	G3 box; other site
557598002086	Switch II region; other site
557598002087	G4 box; other site
557598002088	G5 box; other site
557598002089	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
557598002090	Sm1 motif; other site
557598002091	intra - hexamer interaction site; other site
557598002092	inter - hexamer interaction site [polypeptide binding]; other site
557598002093	nucleotide binding pocket [chemical binding]; other site
557598002094	Sm2 motif; other site
557598002095	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
557598002096	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
557598002097	HflX GTPase family; Region: HflX; cd01878
557598002098	G1 box; other site
557598002099	GTP/Mg2+ binding site [chemical binding]; other site
557598002100	Switch I region; other site
557598002101	G2 box; other site
557598002102	G3 box; other site
557598002103	Switch II region; other site
557598002104	G4 box; other site
557598002105	G5 box; other site
557598002106	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
557598002107	HflK protein; Region: hflK; TIGR01933
557598002108	HflC protein; Region: hflC; TIGR01932
557598002109	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
557598002110	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
557598002111	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
557598002112	dimer interface [polypeptide binding]; other site
557598002113	motif 1; other site
557598002114	active site
557598002115	motif 2; other site
557598002116	motif 3; other site
557598002117	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
557598002118	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
557598002119	GDP-binding site [chemical binding]; other site
557598002120	ACT binding site; other site
557598002121	IMP binding site; other site
557598002122	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
557598002123	dihydrodipicolinate synthase; Region: dapA; TIGR00674
557598002124	dimer interface [polypeptide binding]; other site
557598002125	active site
557598002126	catalytic residue [active]
557598002127	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
557598002128	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598002129	Walker A/P-loop; other site
557598002130	ATP binding site [chemical binding]; other site
557598002131	Q-loop/lid; other site
557598002132	ABC transporter signature motif; other site
557598002133	Walker B; other site
557598002134	D-loop; other site
557598002135	H-loop/switch region; other site
557598002136	ABC transporter; Region: ABC_tran_2; pfam12848
557598002137	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598002138	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
557598002139	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
557598002140	NAD(P) binding site [chemical binding]; other site
557598002141	homotetramer interface [polypeptide binding]; other site
557598002142	homodimer interface [polypeptide binding]; other site
557598002143	active site
557598002144	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598002145	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598002146	dimer interface [polypeptide binding]; other site
557598002147	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598002148	putative CheW interface [polypeptide binding]; other site
557598002149	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
557598002150	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
557598002151	substrate binding site [chemical binding]; other site
557598002152	ligand binding site [chemical binding]; other site
557598002153	Entericidin EcnA/B family; Region: Entericidin; cl02322
557598002154	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
557598002155	substrate binding site [chemical binding]; other site
557598002156	GAF domain; Region: GAF_2; pfam13185
557598002157	GAF domain; Region: GAF; cl15785
557598002158	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002159	metal binding site [ion binding]; metal-binding site
557598002160	active site
557598002161	I-site; other site
557598002162	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
557598002163	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
557598002164	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
557598002165	catalytic triad [active]
557598002166	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
557598002167	elongation factor P; Validated; Region: PRK00529
557598002168	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
557598002169	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
557598002170	RNA binding site [nucleotide binding]; other site
557598002171	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
557598002172	RNA binding site [nucleotide binding]; other site
557598002173	PAS fold; Region: PAS_3; pfam08447
557598002174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002175	metal binding site [ion binding]; metal-binding site
557598002176	active site
557598002177	I-site; other site
557598002178	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
557598002179	GAF domain; Region: GAF; cl15785
557598002180	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
557598002181	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598002182	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598002183	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
557598002184	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
557598002185	AMP-binding enzyme; Region: AMP-binding; cl15778
557598002186	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
557598002187	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
557598002188	homodimer interface [polypeptide binding]; other site
557598002189	substrate-cofactor binding pocket; other site
557598002190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598002191	catalytic residue [active]
557598002192	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
557598002193	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
557598002194	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
557598002195	active site
557598002196	dimer interface [polypeptide binding]; other site
557598002197	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
557598002198	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
557598002199	active site
557598002200	FMN binding site [chemical binding]; other site
557598002201	substrate binding site [chemical binding]; other site
557598002202	3Fe-4S cluster binding site [ion binding]; other site
557598002203	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
557598002204	domain interface; other site
557598002205	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
557598002206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002207	Putative exonuclease, RdgC; Region: RdgC; cl01122
557598002208	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
557598002209	RNA/DNA hybrid binding site [nucleotide binding]; other site
557598002210	active site
557598002211	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
557598002212	putative active site [active]
557598002213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598002214	PAS domain; Region: PAS_9; pfam13426
557598002215	putative active site [active]
557598002216	heme pocket [chemical binding]; other site
557598002217	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598002218	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598002219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598002220	dimer interface [polypeptide binding]; other site
557598002221	putative CheW interface [polypeptide binding]; other site
557598002222	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598002223	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598002224	catalytic residue [active]
557598002225	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
557598002226	ATP cone domain; Region: ATP-cone; pfam03477
557598002227	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
557598002228	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
557598002229	catalytic motif [active]
557598002230	Zn binding site [ion binding]; other site
557598002231	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
557598002232	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
557598002233	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
557598002234	Helix-turn-helix domains; Region: HTH; cl00088
557598002235	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
557598002236	putative dimerization interface [polypeptide binding]; other site
557598002237	LrgA family; Region: LrgA; cl00608
557598002238	LrgB-like family; Region: LrgB; cl00596
557598002239	Flavin Reductases; Region: FlaRed; cl00801
557598002240	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
557598002241	RNAase interaction site [polypeptide binding]; other site
557598002242	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
557598002243	active site
557598002244	Domain of unknown function DUF59; Region: DUF59; cl00941
557598002245	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
557598002246	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
557598002247	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
557598002248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598002249	putative substrate translocation pore; other site
557598002250	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
557598002251	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
557598002252	active site
557598002253	HIGH motif; other site
557598002254	KMSKS motif; other site
557598002255	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
557598002256	tRNA binding surface [nucleotide binding]; other site
557598002257	anticodon binding site; other site
557598002258	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
557598002259	dimer interface [polypeptide binding]; other site
557598002260	putative tRNA-binding site [nucleotide binding]; other site
557598002261	HdeA/HdeB family; Region: HdeA; cl05752
557598002262	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
557598002263	dimer interface [polypeptide binding]; other site
557598002264	motif 1; other site
557598002265	active site
557598002266	motif 2; other site
557598002267	motif 3; other site
557598002268	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
557598002269	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
557598002270	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598002271	active site
557598002272	motif I; other site
557598002273	motif II; other site
557598002274	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
557598002275	putative acyl-acceptor binding pocket; other site
557598002276	Protein of unknown function DUF45; Region: DUF45; cl00636
557598002277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
557598002278	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
557598002279	dimer interface [polypeptide binding]; other site
557598002280	active site
557598002281	metal binding site [ion binding]; metal-binding site
557598002282	glutathione binding site [chemical binding]; other site
557598002283	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
557598002284	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
557598002285	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
557598002286	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
557598002287	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598002288	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598002289	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
557598002290	N-acetyl-D-glucosamine binding site [chemical binding]; other site
557598002291	catalytic residue [active]
557598002292	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
557598002293	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
557598002294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002295	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
557598002296	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
557598002297	G1 box; other site
557598002298	putative GEF interaction site [polypeptide binding]; other site
557598002299	GTP/Mg2+ binding site [chemical binding]; other site
557598002300	Switch I region; other site
557598002301	G2 box; other site
557598002302	G3 box; other site
557598002303	Switch II region; other site
557598002304	G4 box; other site
557598002305	G5 box; other site
557598002306	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
557598002307	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
557598002308	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
557598002309	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
557598002310	selenocysteine synthase; Provisional; Region: PRK04311
557598002311	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
557598002312	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598002313	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598002314	catalytic residue [active]
557598002315	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
557598002316	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
557598002317	ligand binding site [chemical binding]; other site
557598002318	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
557598002319	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
557598002320	TolB amino-terminal domain; Region: TolB_N; cl00639
557598002321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
557598002322	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
557598002323	GMP synthase; Reviewed; Region: guaA; PRK00074
557598002324	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
557598002325	AMP/PPi binding site [chemical binding]; other site
557598002326	candidate oxyanion hole; other site
557598002327	catalytic triad [active]
557598002328	potential glutamine specificity residues [chemical binding]; other site
557598002329	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
557598002330	ATP Binding subdomain [chemical binding]; other site
557598002331	Ligand Binding sites [chemical binding]; other site
557598002332	Dimerization subdomain; other site
557598002333	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
557598002334	SmpB-tmRNA interface; other site
557598002335	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
557598002336	putative coenzyme Q binding site [chemical binding]; other site
557598002337	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
557598002338	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
557598002339	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
557598002340	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
557598002341	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
557598002342	DNA binding residues [nucleotide binding]
557598002343	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
557598002344	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
557598002345	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
557598002346	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598002347	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
557598002348	FHIPEP family; Region: FHIPEP; pfam00771
557598002349	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
557598002350	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
557598002351	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
557598002352	dimerization interface [polypeptide binding]; other site
557598002353	active site
557598002354	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
557598002355	folate binding site [chemical binding]; other site
557598002356	NADP+ binding site [chemical binding]; other site
557598002357	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598002358	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598002359	enoyl-CoA hydratase; Provisional; Region: PRK05995
557598002360	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598002361	substrate binding site [chemical binding]; other site
557598002362	oxyanion hole (OAH) forming residues; other site
557598002363	trimer interface [polypeptide binding]; other site
557598002364	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
557598002365	substrate binding site [chemical binding]; other site
557598002366	dimerization interface [polypeptide binding]; other site
557598002367	active site
557598002368	calcium binding site [ion binding]; other site
557598002369	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
557598002370	recombinase A; Provisional; Region: recA; PRK09354
557598002371	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
557598002372	hexamer interface [polypeptide binding]; other site
557598002373	Walker A motif; other site
557598002374	ATP binding site [chemical binding]; other site
557598002375	Walker B motif; other site
557598002376	RecX family; Region: RecX; cl00936
557598002377	HemK family putative methylases; Region: hemK_fam; TIGR00536
557598002378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598002379	S-adenosylmethionine binding site [chemical binding]; other site
557598002380	LysE type translocator; Region: LysE; cl00565
557598002381	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
557598002382	Helix-turn-helix domains; Region: HTH; cl00088
557598002383	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
557598002384	putative dimerization interface [polypeptide binding]; other site
557598002385	enoyl-CoA hydratase; Provisional; Region: PRK09076
557598002386	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598002387	substrate binding site [chemical binding]; other site
557598002388	oxyanion hole (OAH) forming residues; other site
557598002389	trimer interface [polypeptide binding]; other site
557598002390	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
557598002391	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
557598002392	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
557598002393	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
557598002394	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
557598002395	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
557598002396	4Fe-4S binding domain; Region: Fer4; cl02805
557598002397	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
557598002398	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
557598002399	molybdopterin cofactor binding site; other site
557598002400	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
557598002401	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
557598002402	molybdopterin cofactor binding site; other site
557598002403	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
557598002404	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
557598002405	aspartate kinase; Reviewed; Region: PRK06635
557598002406	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
557598002407	putative nucleotide binding site [chemical binding]; other site
557598002408	putative catalytic residues [active]
557598002409	putative Mg ion binding site [ion binding]; other site
557598002410	putative aspartate binding site [chemical binding]; other site
557598002411	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
557598002412	putative allosteric regulatory site; other site
557598002413	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
557598002414	putative allosteric regulatory residue; other site
557598002415	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
557598002416	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
557598002417	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
557598002418	Domain of unknown function (DUF932); Region: DUF932; cl12129
557598002419	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598002420	PAS domain; Region: PAS_9; pfam13426
557598002421	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
557598002422	GAF domain; Region: GAF; cl15785
557598002423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598002424	PAS domain; Region: PAS_9; pfam13426
557598002425	putative active site [active]
557598002426	heme pocket [chemical binding]; other site
557598002427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002428	metal binding site [ion binding]; metal-binding site
557598002429	active site
557598002430	I-site; other site
557598002431	Integrase core domain; Region: rve_3; cl15866
557598002432	Helix-turn-helix domains; Region: HTH; cl00088
557598002433	Helix-turn-helix domains; Region: HTH; cl00088
557598002434	Bacterial sugar transferase; Region: Bac_transf; cl00939
557598002435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598002436	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
557598002437	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
557598002438	anti sigma factor interaction site; other site
557598002439	regulatory phosphorylation site [posttranslational modification]; other site
557598002440	Response regulator receiver domain; Region: Response_reg; pfam00072
557598002441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598002442	active site
557598002443	phosphorylation site [posttranslational modification]
557598002444	intermolecular recognition site; other site
557598002445	dimerization interface [polypeptide binding]; other site
557598002446	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
557598002447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598002448	PAS domain; Region: PAS_9; pfam13426
557598002449	putative active site [active]
557598002450	heme pocket [chemical binding]; other site
557598002451	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
557598002452	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
557598002453	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
557598002454	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
557598002455	Substrate binding site; other site
557598002456	Cupin domain; Region: Cupin_2; cl09118
557598002457	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
557598002458	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
557598002459	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
557598002460	SLBB domain; Region: SLBB; pfam10531
557598002461	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
557598002462	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
557598002463	active site
557598002464	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356
557598002465	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
557598002466	trimer interface [polypeptide binding]; other site
557598002467	active site
557598002468	substrate binding site [chemical binding]; other site
557598002469	CoA binding site [chemical binding]; other site
557598002470	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
557598002471	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
557598002472	putative ADP-binding pocket [chemical binding]; other site
557598002473	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
557598002474	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598002475	active site
557598002476	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598002477	MatE; Region: MatE; cl10513
557598002478	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
557598002479	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
557598002480	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
557598002481	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
557598002482	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
557598002483	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
557598002484	DXD motif; other site
557598002485	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
557598002486	trimer interface [polypeptide binding]; other site
557598002487	active site
557598002488	substrate binding site [chemical binding]; other site
557598002489	CoA binding site [chemical binding]; other site
557598002490	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598002491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598002492	PAS fold; Region: PAS_4; pfam08448
557598002493	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
557598002494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598002495	Walker A motif; other site
557598002496	ATP binding site [chemical binding]; other site
557598002497	Walker B motif; other site
557598002498	arginine finger; other site
557598002499	Helix-turn-helix domains; Region: HTH; cl00088
557598002500	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
557598002501	Amidinotransferase; Region: Amidinotransf; cl12043
557598002502	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
557598002503	Acylphosphatase; Region: Acylphosphatase; cl00551
557598002504	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
557598002505	HypF finger; Region: zf-HYPF; pfam07503
557598002506	HypF finger; Region: zf-HYPF; pfam07503
557598002507	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
557598002508	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
557598002509	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598002510	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598002511	catalytic residue [active]
557598002512	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
557598002513	classical (c) SDRs; Region: SDR_c; cd05233
557598002514	NAD(P) binding site [chemical binding]; other site
557598002515	active site
557598002516	Creatinine amidohydrolase; Region: Creatininase; cl00618
557598002517	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
557598002518	catalytic nucleophile [active]
557598002519	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
557598002520	Sodium:solute symporter family; Region: SSF; cl00456
557598002521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
557598002522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
557598002523	substrate binding pocket [chemical binding]; other site
557598002524	membrane-bound complex binding site; other site
557598002525	hinge residues; other site
557598002526	H-NS histone family; Region: Histone_HNS; pfam00816
557598002527	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
557598002528	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
557598002529	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
557598002530	active site
557598002531	FMN binding site [chemical binding]; other site
557598002532	substrate binding site [chemical binding]; other site
557598002533	catalytic residues [active]
557598002534	homodimer interface [polypeptide binding]; other site
557598002535	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
557598002536	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
557598002537	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
557598002538	B3/4 domain; Region: B3_4; cl11458
557598002539	YccA-like proteins; Region: YccA_like; cd10433
557598002540	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
557598002541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002542	metal binding site [ion binding]; metal-binding site
557598002543	active site
557598002544	I-site; other site
557598002545	trigger factor; Provisional; Region: tig; PRK01490
557598002546	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
557598002547	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
557598002548	Clp protease; Region: CLP_protease; pfam00574
557598002549	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
557598002550	oligomer interface [polypeptide binding]; other site
557598002551	active site residues [active]
557598002552	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
557598002553	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
557598002554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598002555	Walker A motif; other site
557598002556	ATP binding site [chemical binding]; other site
557598002557	Walker B motif; other site
557598002558	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
557598002559	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353
557598002560	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
557598002561	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
557598002562	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
557598002563	hinge; other site
557598002564	active site
557598002565	cytidylate kinase; Provisional; Region: cmk; PRK00023
557598002566	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
557598002567	CMP-binding site; other site
557598002568	The sites determining sugar specificity; other site
557598002569	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
557598002570	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
557598002571	RNA binding site [nucleotide binding]; other site
557598002572	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
557598002573	RNA binding site [nucleotide binding]; other site
557598002574	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
557598002575	RNA binding site [nucleotide binding]; other site
557598002576	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
557598002577	RNA binding site [nucleotide binding]; other site
557598002578	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
557598002579	RNA binding site [nucleotide binding]; other site
557598002580	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
557598002581	RNA binding site [nucleotide binding]; other site
557598002582	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
557598002583	IHF dimer interface [polypeptide binding]; other site
557598002584	IHF - DNA interface [nucleotide binding]; other site
557598002585	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
557598002586	tetratricopeptide repeat protein; Provisional; Region: PRK11788
557598002587	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598002588	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
557598002589	active site
557598002590	dimer interface [polypeptide binding]; other site
557598002591	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
557598002592	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
557598002593	putative ribose interaction site [chemical binding]; other site
557598002594	putative ADP binding site [chemical binding]; other site
557598002595	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
557598002596	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
557598002597	NADP binding site [chemical binding]; other site
557598002598	homopentamer interface [polypeptide binding]; other site
557598002599	substrate binding site [chemical binding]; other site
557598002600	active site
557598002601	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
557598002602	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
557598002603	N-acetyl-D-glucosamine binding site [chemical binding]; other site
557598002604	catalytic residue [active]
557598002605	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
557598002606	autolysin; Reviewed; Region: PRK06347
557598002607	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
557598002608	putative peptidoglycan binding site; other site
557598002609	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
557598002610	putative peptidoglycan binding site; other site
557598002611	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
557598002612	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
557598002613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002614	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
557598002615	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
557598002616	RNA/DNA hybrid binding site [nucleotide binding]; other site
557598002617	active site
557598002618	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
557598002619	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
557598002620	active site
557598002621	catalytic site [active]
557598002622	substrate binding site [chemical binding]; other site
557598002623	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
557598002624	substrate binding site; other site
557598002625	dimer interface; other site
557598002626	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
557598002627	homotrimer interaction site [polypeptide binding]; other site
557598002628	zinc binding site [ion binding]; other site
557598002629	CDP-binding sites; other site
557598002630	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
557598002631	tetramer (dimer of dimers) interface [polypeptide binding]; other site
557598002632	active site
557598002633	dimer interface [polypeptide binding]; other site
557598002634	transcriptional regulator PhoU; Provisional; Region: PRK11115
557598002635	PhoU domain; Region: PhoU; pfam01895
557598002636	PhoU domain; Region: PhoU; pfam01895
557598002637	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
557598002638	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
557598002639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
557598002640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598002641	active site
557598002642	phosphorylation site [posttranslational modification]
557598002643	intermolecular recognition site; other site
557598002644	dimerization interface [polypeptide binding]; other site
557598002645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598002646	DNA binding site [nucleotide binding]
557598002647	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
557598002648	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
557598002649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598002650	dimer interface [polypeptide binding]; other site
557598002651	phosphorylation site [posttranslational modification]
557598002652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598002653	ATP binding site [chemical binding]; other site
557598002654	Mg2+ binding site [ion binding]; other site
557598002655	G-X-G motif; other site
557598002656	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598002657	Ligand Binding Site [chemical binding]; other site
557598002658	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598002659	Ligand Binding Site [chemical binding]; other site
557598002660	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598002661	Excalibur calcium-binding domain; Region: Excalibur; cl05460
557598002662	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
557598002663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598002664	non-specific DNA binding site [nucleotide binding]; other site
557598002665	salt bridge; other site
557598002666	sequence-specific DNA binding site [nucleotide binding]; other site
557598002667	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
557598002668	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
557598002669	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598002670	active site
557598002671	DNA binding site [nucleotide binding]
557598002672	Int/Topo IB signature motif; other site
557598002673	phosphoglycolate phosphatase; Provisional; Region: PRK13226
557598002674	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598002675	motif II; other site
557598002676	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598002677	Integrase core domain; Region: rve; cl01316
557598002678	Membrane transport protein; Region: Mem_trans; cl09117
557598002679	Membrane transport protein; Region: Mem_trans; cl09117
557598002680	AIPR protein; Region: AIPR; pfam10592
557598002681	Replication protein; Region: Rep_1; cl02412
557598002682	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
557598002683	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
557598002684	catalytic residues [active]
557598002685	catalytic nucleophile [active]
557598002686	Recombinase; Region: Recombinase; pfam07508
557598002687	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
557598002688	potential frameshift: common BLAST hit: gi|134293367|ref|YP_001117103.1| arsenite-activated ATPase ArsA
557598002689	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
557598002690	P loop; other site
557598002691	Nucleotide binding site [chemical binding]; other site
557598002692	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
557598002693	DTAP/Switch II; other site
557598002694	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
557598002695	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
557598002696	P loop; other site
557598002697	Nucleotide binding site [chemical binding]; other site
557598002698	Switch I; other site
557598002699	potential frameshift: common BLAST hit: gi|94313018|ref|YP_586227.1| NADH:flavin oxidoreductase/NADH oxidase
557598002700	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
557598002701	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
557598002702	phosphate binding site [ion binding]; other site
557598002703	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
557598002704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598002705	S-adenosylmethionine binding site [chemical binding]; other site
557598002706	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
557598002707	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
557598002708	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
557598002709	DNA-binding site [nucleotide binding]; DNA binding site
557598002710	RNA-binding motif; other site
557598002711	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
557598002712	rRNA binding site [nucleotide binding]; other site
557598002713	predicted 30S ribosome binding site; other site
557598002714	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
557598002715	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002716	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
557598002717	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
557598002718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002719	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
557598002720	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
557598002721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002722	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
557598002723	peroxidase; Provisional; Region: PRK15000
557598002724	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
557598002725	dimer interface [polypeptide binding]; other site
557598002726	decamer (pentamer of dimers) interface [polypeptide binding]; other site
557598002727	catalytic triad [active]
557598002728	peroxidatic and resolving cysteines [active]
557598002729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598002730	dimer interface [polypeptide binding]; other site
557598002731	conserved gate region; other site
557598002732	ABC-ATPase subunit interface; other site
557598002733	dipeptide transporter; Provisional; Region: PRK10913
557598002734	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
557598002735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598002736	dimer interface [polypeptide binding]; other site
557598002737	conserved gate region; other site
557598002738	putative PBP binding loops; other site
557598002739	ABC-ATPase subunit interface; other site
557598002740	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
557598002741	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
557598002742	Walker A/P-loop; other site
557598002743	ATP binding site [chemical binding]; other site
557598002744	Q-loop/lid; other site
557598002745	ABC transporter signature motif; other site
557598002746	Walker B; other site
557598002747	D-loop; other site
557598002748	H-loop/switch region; other site
557598002749	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
557598002750	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
557598002751	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
557598002752	Walker A/P-loop; other site
557598002753	ATP binding site [chemical binding]; other site
557598002754	Q-loop/lid; other site
557598002755	ABC transporter signature motif; other site
557598002756	Walker B; other site
557598002757	D-loop; other site
557598002758	H-loop/switch region; other site
557598002759	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
557598002760	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
557598002761	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
557598002762	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598002763	FeS/SAM binding site; other site
557598002764	TRAM domain; Region: TRAM; cl01282
557598002765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
557598002766	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
557598002767	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
557598002768	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
557598002769	Phasin protein; Region: Phasin_2; cl11491
557598002770	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
557598002771	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
557598002772	putative active site [active]
557598002773	Zn binding site [ion binding]; other site
557598002774	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598002775	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
557598002776	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598002777	metal binding site [ion binding]; metal-binding site
557598002778	active site
557598002779	I-site; other site
557598002780	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
557598002781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598002782	DNA-binding site [nucleotide binding]; DNA binding site
557598002783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598002784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598002785	homodimer interface [polypeptide binding]; other site
557598002786	catalytic residue [active]
557598002787	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
557598002788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598002789	S-adenosylmethionine binding site [chemical binding]; other site
557598002790	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
557598002791	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
557598002792	active site
557598002793	putative substrate binding pocket [chemical binding]; other site
557598002794	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
557598002795	Haemolysin-III related; Region: HlyIII; cl03831
557598002796	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
557598002797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598002798	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598002799	active site
557598002800	H-NS histone family; Region: Histone_HNS; pfam00816
557598002801	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
557598002802	excinuclease ABC subunit B; Provisional; Region: PRK05298
557598002803	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598002804	ATP binding site [chemical binding]; other site
557598002805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598002806	nucleotide binding region [chemical binding]; other site
557598002807	ATP-binding site [chemical binding]; other site
557598002808	Ultra-violet resistance protein B; Region: UvrB; pfam12344
557598002809	D-lactate dehydrogenase [cytochrome]; Region: PLN02805
557598002810	FAD binding domain; Region: FAD_binding_4; pfam01565
557598002811	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
557598002812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598002813	Walker A motif; other site
557598002814	ATP binding site [chemical binding]; other site
557598002815	Walker B motif; other site
557598002816	arginine finger; other site
557598002817	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
557598002818	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
557598002819	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
557598002820	recombination protein RecR; Reviewed; Region: recR; PRK00076
557598002821	RecR protein; Region: RecR; pfam02132
557598002822	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
557598002823	putative active site [active]
557598002824	putative metal-binding site [ion binding]; other site
557598002825	tetramer interface [polypeptide binding]; other site
557598002826	ParA-like protein; Provisional; Region: PHA02518
557598002827	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
557598002828	P-loop; other site
557598002829	Magnesium ion binding site [ion binding]; other site
557598002830	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
557598002831	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
557598002832	CHAD domain; Region: CHAD; cl10506
557598002833	Ion transport protein; Region: Ion_trans; pfam00520
557598002834	Ion channel; Region: Ion_trans_2; cl11596
557598002835	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
557598002836	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
557598002837	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
557598002838	dimer interface [polypeptide binding]; other site
557598002839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598002840	catalytic residue [active]
557598002841	lipoyl synthase; Provisional; Region: PRK05481
557598002842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598002843	FeS/SAM binding site; other site
557598002844	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
557598002845	Protein of unknown function (DUF493); Region: DUF493; cl01102
557598002846	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
557598002847	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598002848	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
557598002849	threonine dehydratase; Reviewed; Region: PRK09224
557598002850	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
557598002851	tetramer interface [polypeptide binding]; other site
557598002852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598002853	catalytic residue [active]
557598002854	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
557598002855	putative Ile/Val binding site [chemical binding]; other site
557598002856	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
557598002857	putative Ile/Val binding site [chemical binding]; other site
557598002858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598002859	D-galactonate transporter; Region: 2A0114; TIGR00893
557598002860	putative substrate translocation pore; other site
557598002861	membrane protein FdrA; Validated; Region: PRK06091
557598002862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002863	CoA-ligase; Region: Ligase_CoA; cl02894
557598002864	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
557598002865	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
557598002866	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
557598002867	Helix-turn-helix domains; Region: HTH; cl00088
557598002868	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598002869	dimerization interface [polypeptide binding]; other site
557598002870	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
557598002871	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
557598002872	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
557598002873	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598002874	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
557598002875	CoA-transferase family III; Region: CoA_transf_3; pfam02515
557598002876	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
557598002877	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
557598002878	dimer interface [polypeptide binding]; other site
557598002879	active site
557598002880	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
557598002881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598002882	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
557598002883	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
557598002884	enoyl-CoA hydratase; Provisional; Region: PRK08138
557598002885	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598002886	substrate binding site [chemical binding]; other site
557598002887	oxyanion hole (OAH) forming residues; other site
557598002888	trimer interface [polypeptide binding]; other site
557598002889	Transcriptional regulator [Transcription]; Region: IclR; COG1414
557598002890	Helix-turn-helix domains; Region: HTH; cl00088
557598002891	Bacterial transcriptional regulator; Region: IclR; pfam01614
557598002892	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
557598002893	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
557598002894	active site
557598002895	benzoate transport; Region: 2A0115; TIGR00895
557598002896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598002897	putative substrate translocation pore; other site
557598002898	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
557598002899	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
557598002900	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
557598002901	Low-spin heme binding site [chemical binding]; other site
557598002902	Putative water exit pathway; other site
557598002903	Binuclear center (active site) [active]
557598002904	Putative proton exit pathway; other site
557598002905	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
557598002906	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
557598002907	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
557598002908	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
557598002909	Cytochrome c; Region: Cytochrom_C; cl11414
557598002910	Cytochrome c; Region: Cytochrom_C; cl11414
557598002911	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
557598002912	4Fe-4S binding domain; Region: Fer4_5; pfam12801
557598002913	4Fe-4S binding domain; Region: Fer4; cl02805
557598002914	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
557598002915	FixH; Region: FixH; cl01254
557598002916	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
557598002917	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
557598002918	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
557598002919	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
557598002920	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
557598002921	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
557598002922	active site
557598002923	HIGH motif; other site
557598002924	KMSK motif region; other site
557598002925	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
557598002926	tRNA binding surface [nucleotide binding]; other site
557598002927	anticodon binding site; other site
557598002928	Protein of unknown function (DUF461); Region: DUF461; cl01071
557598002929	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
557598002930	Gram-negative bacterial tonB protein; Region: TonB; cl10048
557598002931	Methyltransferase domain; Region: Methyltransf_31; pfam13847
557598002932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598002933	S-adenosylmethionine binding site [chemical binding]; other site
557598002934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420
557598002935	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
557598002936	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
557598002937	active site
557598002938	catalytic site [active]
557598002939	substrate binding site [chemical binding]; other site
557598002940	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
557598002941	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
557598002942	ligand binding site [chemical binding]; other site
557598002943	flexible hinge region; other site
557598002944	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
557598002945	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
557598002946	metal binding triad; other site
557598002947	Benzoate membrane transport protein; Region: BenE; pfam03594
557598002948	benzoate transporter; Region: benE; TIGR00843
557598002949	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
557598002950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598002951	ATP binding site [chemical binding]; other site
557598002952	Mg2+ binding site [ion binding]; other site
557598002953	G-X-G motif; other site
557598002954	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
557598002955	ATP binding site [chemical binding]; other site
557598002956	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
557598002957	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
557598002958	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
557598002959	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
557598002960	Protein export membrane protein; Region: SecD_SecF; cl14618
557598002961	PAS domain S-box; Region: sensory_box; TIGR00229
557598002962	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598002963	putative active site [active]
557598002964	heme pocket [chemical binding]; other site
557598002965	PAS fold; Region: PAS_7; pfam12860
557598002966	PAS fold; Region: PAS_3; pfam08447
557598002967	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
557598002968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598002969	dimer interface [polypeptide binding]; other site
557598002970	phosphorylation site [posttranslational modification]
557598002971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598002972	ATP binding site [chemical binding]; other site
557598002973	Mg2+ binding site [ion binding]; other site
557598002974	G-X-G motif; other site
557598002975	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
557598002976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598002977	active site
557598002978	phosphorylation site [posttranslational modification]
557598002979	intermolecular recognition site; other site
557598002980	dimerization interface [polypeptide binding]; other site
557598002981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598002982	Response regulator receiver domain; Region: Response_reg; pfam00072
557598002983	active site
557598002984	phosphorylation site [posttranslational modification]
557598002985	intermolecular recognition site; other site
557598002986	dimerization interface [polypeptide binding]; other site
557598002987	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
557598002988	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
557598002989	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
557598002990	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
557598002991	putative active site [active]
557598002992	putative substrate binding site [chemical binding]; other site
557598002993	putative cosubstrate binding site; other site
557598002994	catalytic site [active]
557598002995	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
557598002996	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
557598002997	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
557598002998	homodimer interface [polypeptide binding]; other site
557598002999	NADP binding site [chemical binding]; other site
557598003000	substrate binding site [chemical binding]; other site
557598003001	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
557598003002	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
557598003003	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598003004	dimer interface [polypeptide binding]; other site
557598003005	putative CheW interface [polypeptide binding]; other site
557598003006	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598003007	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
557598003008	potential frameshift: common BLAST hit: gi|171058644|ref|YP_001790993.1| integrase catalytic region
557598003009	Integrase core domain; Region: rve_3; cl15866
557598003010	Integrase core domain; Region: rve; cl01316
557598003011	Helix-turn-helix domains; Region: HTH; cl00088
557598003012	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
557598003013	trimer interface [polypeptide binding]; other site
557598003014	eyelet of channel; other site
557598003015	LysE type translocator; Region: LysE; cl00565
557598003016	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598003017	active site
557598003018	I-site; other site
557598003019	metal binding site [ion binding]; metal-binding site
557598003020	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598003021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598003022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598003023	PAS domain; Region: PAS_9; pfam13426
557598003024	putative active site [active]
557598003025	heme pocket [chemical binding]; other site
557598003026	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
557598003027	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
557598003028	ligand binding site [chemical binding]; other site
557598003029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
557598003030	lysine decarboxylase LdcC; Provisional; Region: PRK15399
557598003031	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598003032	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598003033	catalytic residue [active]
557598003034	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
557598003035	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
557598003036	alpha-gamma subunit interface [polypeptide binding]; other site
557598003037	beta-gamma subunit interface [polypeptide binding]; other site
557598003038	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
557598003039	gamma-beta subunit interface [polypeptide binding]; other site
557598003040	alpha-beta subunit interface [polypeptide binding]; other site
557598003041	urease subunit alpha; Reviewed; Region: ureC; PRK13207
557598003042	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
557598003043	subunit interactions [polypeptide binding]; other site
557598003044	active site
557598003045	flap region; other site
557598003046	CrcB-like protein; Region: CRCB; cl09114
557598003047	CrcB-like protein; Region: CRCB; cl09114
557598003048	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
557598003049	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
557598003050	dimer interface [polypeptide binding]; other site
557598003051	catalytic residues [active]
557598003052	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
557598003053	UreF; Region: UreF; pfam01730
557598003054	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003055	UreD urease accessory protein; Region: UreD; cl00530
557598003056	Urea transporter; Region: UT; cl01829
557598003057	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
557598003058	PDGLE domain; Region: PDGLE; cl07986
557598003059	HdeA/HdeB family; Region: HdeA; cl05752
557598003060	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
557598003061	Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776
557598003062	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
557598003063	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
557598003064	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598003065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598003066	motif II; other site
557598003067	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
557598003068	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
557598003069	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
557598003070	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
557598003071	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
557598003072	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003073	Walker A motif; other site
557598003074	ATP binding site [chemical binding]; other site
557598003075	Walker B motif; other site
557598003076	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
557598003077	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
557598003078	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
557598003079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598003080	Walker A motif; other site
557598003081	ATP binding site [chemical binding]; other site
557598003082	Walker B motif; other site
557598003083	arginine finger; other site
557598003084	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
557598003085	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
557598003086	Walker A/P-loop; other site
557598003087	ATP binding site [chemical binding]; other site
557598003088	Q-loop/lid; other site
557598003089	ABC transporter signature motif; other site
557598003090	Walker B; other site
557598003091	D-loop; other site
557598003092	H-loop/switch region; other site
557598003093	Permease; Region: Permease; cl00510
557598003094	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
557598003095	mce related protein; Region: MCE; pfam02470
557598003096	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
557598003097	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
557598003098	VacJ like lipoprotein; Region: VacJ; cl01073
557598003099	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
557598003100	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598003101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598003102	homodimer interface [polypeptide binding]; other site
557598003103	catalytic residue [active]
557598003104	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
557598003105	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
557598003106	tandem repeat interface [polypeptide binding]; other site
557598003107	oligomer interface [polypeptide binding]; other site
557598003108	active site residues [active]
557598003109	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
557598003110	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598003111	motif II; other site
557598003112	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
557598003113	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
557598003114	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
557598003115	active site
557598003116	ribonuclease E; Reviewed; Region: rne; PRK10811
557598003117	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
557598003118	homodimer interface [polypeptide binding]; other site
557598003119	oligonucleotide binding site [chemical binding]; other site
557598003120	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
557598003121	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
557598003122	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
557598003123	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cl09835
557598003124	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
557598003125	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
557598003126	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598003127	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
557598003128	Cobalt transport protein; Region: CbiQ; cl00463
557598003129	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
557598003130	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
557598003131	Walker A/P-loop; other site
557598003132	ATP binding site [chemical binding]; other site
557598003133	Q-loop/lid; other site
557598003134	ABC transporter signature motif; other site
557598003135	Walker B; other site
557598003136	D-loop; other site
557598003137	H-loop/switch region; other site
557598003138	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
557598003139	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
557598003140	Cl- selectivity filter; other site
557598003141	Cl- binding residues [ion binding]; other site
557598003142	pore gating glutamate residue; other site
557598003143	dimer interface [polypeptide binding]; other site
557598003144	H+/Cl- coupling transport residue; other site
557598003145	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
557598003146	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
557598003147	N-terminal plug; other site
557598003148	ligand-binding site [chemical binding]; other site
557598003149	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
557598003150	putative peptidoglycan binding site; other site
557598003151	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
557598003152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003153	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598003154	Helix-turn-helix domains; Region: HTH; cl00088
557598003155	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
557598003156	putative effector binding pocket; other site
557598003157	dimerization interface [polypeptide binding]; other site
557598003158	DoxX; Region: DoxX; cl00976
557598003159	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
557598003160	putative active site [active]
557598003161	metal binding site [ion binding]; metal-binding site
557598003162	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
557598003163	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003164	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003165	ABC transporter; Region: ABC_tran_2; pfam12848
557598003166	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003167	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598003168	active site
557598003169	DNA binding site [nucleotide binding]
557598003170	Int/Topo IB signature motif; other site
557598003171	selenophosphate synthetase; Provisional; Region: PRK00943
557598003172	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
557598003173	dimerization interface [polypeptide binding]; other site
557598003174	putative ATP binding site [chemical binding]; other site
557598003175	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
557598003176	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
557598003177	active site residue [active]
557598003178	amino acid transporter; Region: 2A0306; TIGR00909
557598003179	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
557598003180	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
557598003181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
557598003182	GAF domain; Region: GAF; cl15785
557598003183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598003184	metal binding site [ion binding]; metal-binding site
557598003185	active site
557598003186	I-site; other site
557598003187	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
557598003188	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
557598003189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598003190	dimer interface [polypeptide binding]; other site
557598003191	conserved gate region; other site
557598003192	putative PBP binding loops; other site
557598003193	ABC-ATPase subunit interface; other site
557598003194	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
557598003195	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
557598003196	Walker A/P-loop; other site
557598003197	ATP binding site [chemical binding]; other site
557598003198	Q-loop/lid; other site
557598003199	ABC transporter signature motif; other site
557598003200	Walker B; other site
557598003201	D-loop; other site
557598003202	H-loop/switch region; other site
557598003203	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
557598003204	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
557598003205	Walker A/P-loop; other site
557598003206	ATP binding site [chemical binding]; other site
557598003207	Q-loop/lid; other site
557598003208	ABC transporter signature motif; other site
557598003209	Walker B; other site
557598003210	D-loop; other site
557598003211	H-loop/switch region; other site
557598003212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
557598003213	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
557598003214	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
557598003215	generic binding surface II; other site
557598003216	generic binding surface I; other site
557598003217	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
557598003218	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
557598003219	Trm112p-like protein; Region: Trm112p; cl01066
557598003220	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
557598003221	Ligand binding site; other site
557598003222	oligomer interface; other site
557598003223	adenylate kinase; Reviewed; Region: adk; PRK00279
557598003224	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
557598003225	AMP-binding site [chemical binding]; other site
557598003226	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
557598003227	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598003228	PrkA family serine protein kinase; Provisional; Region: PRK15455
557598003229	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003230	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
557598003231	Uncharacterized conserved protein [Function unknown]; Region: COG2718
557598003232	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
557598003233	SpoVR family protein; Provisional; Region: PRK11767
557598003234	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
557598003235	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
557598003236	NAD(P) binding site [chemical binding]; other site
557598003237	homotetramer interface [polypeptide binding]; other site
557598003238	homodimer interface [polypeptide binding]; other site
557598003239	active site
557598003240	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
557598003241	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
557598003242	putative acyltransferase; Provisional; Region: PRK05790
557598003243	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
557598003244	dimer interface [polypeptide binding]; other site
557598003245	active site
557598003246	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
557598003247	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
557598003248	HIGH motif; other site
557598003249	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
557598003250	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
557598003251	active site
557598003252	KMSKS motif; other site
557598003253	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
557598003254	tRNA binding surface [nucleotide binding]; other site
557598003255	anticodon binding site; other site
557598003256	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
557598003257	Uncharacterized conserved protein [Function unknown]; Region: COG3287
557598003258	FIST N domain; Region: FIST; cl10701
557598003259	FIST C domain; Region: FIST_C; pfam10442
557598003260	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598003261	metal binding site [ion binding]; metal-binding site
557598003262	active site
557598003263	I-site; other site
557598003264	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598003265	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598003266	dimer interface [polypeptide binding]; other site
557598003267	putative CheW interface [polypeptide binding]; other site
557598003268	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
557598003269	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
557598003270	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
557598003271	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
557598003272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598003273	FeS/SAM binding site; other site
557598003274	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
557598003275	active site
557598003276	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
557598003277	active site
557598003278	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
557598003279	Ligand Binding Site [chemical binding]; other site
557598003280	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598003281	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
557598003282	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
557598003283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598003284	metal binding site [ion binding]; metal-binding site
557598003285	active site
557598003286	I-site; other site
557598003287	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
557598003288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598003289	active site
557598003290	phosphorylation site [posttranslational modification]
557598003291	intermolecular recognition site; other site
557598003292	dimerization interface [polypeptide binding]; other site
557598003293	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598003294	DNA binding site [nucleotide binding]
557598003295	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
557598003296	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
557598003297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
557598003298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598003299	dimer interface [polypeptide binding]; other site
557598003300	phosphorylation site [posttranslational modification]
557598003301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598003302	ATP binding site [chemical binding]; other site
557598003303	Mg2+ binding site [ion binding]; other site
557598003304	G-X-G motif; other site
557598003305	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
557598003306	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598003307	Arginase family; Region: Arginase; cl00306
557598003308	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598003309	Phage Tail Collar Domain; Region: Collar; pfam07484
557598003310	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
557598003311	Baseplate J-like protein; Region: Baseplate_J; cl01294
557598003312	Phage protein GP46; Region: GP46; cl01814
557598003313	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
557598003314	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
557598003315	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598003316	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
557598003317	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
557598003318	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
557598003319	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
557598003320	Domain of unknown function (DUF1834); Region: DUF1834; cl02087
557598003321	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
557598003322	amidase catalytic site [active]
557598003323	Zn binding residues [ion binding]; other site
557598003324	substrate binding site [chemical binding]; other site
557598003325	Mor transcription activator family; Region: Mor; cl02360
557598003326	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
557598003327	AAA domain; Region: AAA_22; pfam13401
557598003328	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
557598003329	Integrase core domain; Region: rve; cl01316
557598003330	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
557598003331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
557598003332	Predicted transcriptional regulator [Transcription]; Region: COG2932
557598003333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
557598003334	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
557598003335	Catalytic site [active]
557598003336	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
557598003337	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598003338	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598003339	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598003340	potential frameshift: common BLAST hit: gi|171058644|ref|YP_001790993.1| integrase catalytic region
557598003341	Integrase core domain; Region: rve_3; cl15866
557598003342	Integrase core domain; Region: rve; cl01316
557598003343	Helix-turn-helix domains; Region: HTH; cl00088
557598003344	potential frameshift: common BLAST hit: gi|194288968|ref|YP_002004875.1| type I restriction-modification deoxyribonuclease, R subunit
557598003345	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
557598003346	potential frameshift: common BLAST hit: gi|15676962|ref|NP_274113.1| bacteriophage transposase
557598003347	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
557598003348	NMT1-like family; Region: NMT1_2; cl15260
557598003349	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
557598003350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598003351	putative PBP binding loops; other site
557598003352	dimer interface [polypeptide binding]; other site
557598003353	ABC-ATPase subunit interface; other site
557598003354	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
557598003355	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
557598003356	Walker A/P-loop; other site
557598003357	ATP binding site [chemical binding]; other site
557598003358	Q-loop/lid; other site
557598003359	ABC transporter signature motif; other site
557598003360	Walker B; other site
557598003361	D-loop; other site
557598003362	H-loop/switch region; other site
557598003363	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
557598003364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598003365	dimer interface [polypeptide binding]; other site
557598003366	phosphorylation site [posttranslational modification]
557598003367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598003368	ATP binding site [chemical binding]; other site
557598003369	Mg2+ binding site [ion binding]; other site
557598003370	G-X-G motif; other site
557598003371	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
557598003372	putative substrate binding pocket [chemical binding]; other site
557598003373	trimer interface [polypeptide binding]; other site
557598003374	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
557598003375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598003376	active site
557598003377	phosphorylation site [posttranslational modification]
557598003378	intermolecular recognition site; other site
557598003379	dimerization interface [polypeptide binding]; other site
557598003380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598003381	Walker A motif; other site
557598003382	ATP binding site [chemical binding]; other site
557598003383	Walker B motif; other site
557598003384	arginine finger; other site
557598003385	Helix-turn-helix domains; Region: HTH; cl00088
557598003386	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
557598003387	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
557598003388	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
557598003389	ABC-ATPase subunit  interface; other site
557598003390	dimer interface [polypeptide binding]; other site
557598003391	putative PBP binding regions; other site
557598003392	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
557598003393	intersubunit interface [polypeptide binding]; other site
557598003394	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
557598003395	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
557598003396	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
557598003397	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
557598003398	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
557598003399	N-terminal plug; other site
557598003400	ligand-binding site [chemical binding]; other site
557598003401	Hemin uptake protein hemP; Region: hemP; cl10043
557598003402	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
557598003403	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
557598003404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003405	NAD(P) binding site [chemical binding]; other site
557598003406	active site
557598003407	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
557598003408	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
557598003409	substrate binding site [chemical binding]; other site
557598003410	hexamer interface [polypeptide binding]; other site
557598003411	metal binding site [ion binding]; metal-binding site
557598003412	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
557598003413	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
557598003414	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003415	Family description; Region: UvrD_C_2; cl15862
557598003416	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
557598003417	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003418	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
557598003419	Family description; Region: UvrD_C_2; cl15862
557598003420	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
557598003421	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
557598003422	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
557598003423	Transglycosylase SLT domain; Region: SLT_2; pfam13406
557598003424	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
557598003425	N-acetyl-D-glucosamine binding site [chemical binding]; other site
557598003426	catalytic residue [active]
557598003427	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
557598003428	Helix-turn-helix domains; Region: HTH; cl00088
557598003429	HrcA protein C terminal domain; Region: HrcA; pfam01628
557598003430	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
557598003431	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
557598003432	putative MPT binding site; other site
557598003433	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
557598003434	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
557598003435	Walker A/P-loop; other site
557598003436	ATP binding site [chemical binding]; other site
557598003437	Q-loop/lid; other site
557598003438	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
557598003439	ABC transporter signature motif; other site
557598003440	Walker B; other site
557598003441	D-loop; other site
557598003442	H-loop/switch region; other site
557598003443	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
557598003444	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
557598003445	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598003446	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598003447	dimer interface [polypeptide binding]; other site
557598003448	putative CheW interface [polypeptide binding]; other site
557598003449	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
557598003450	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598003451	FeS/SAM binding site; other site
557598003452	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
557598003453	MarC family integral membrane protein; Region: MarC; cl00919
557598003454	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
557598003455	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
557598003456	active site
557598003457	purine riboside binding site [chemical binding]; other site
557598003458	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
557598003459	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
557598003460	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
557598003461	protein binding site [polypeptide binding]; other site
557598003462	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
557598003463	protein binding site [polypeptide binding]; other site
557598003464	endonuclease III; Provisional; Region: PRK10702
557598003465	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
557598003466	minor groove reading motif; other site
557598003467	helix-hairpin-helix signature motif; other site
557598003468	substrate binding pocket [chemical binding]; other site
557598003469	active site
557598003470	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
557598003471	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
557598003472	FMN-binding domain; Region: FMN_bind; cl01081
557598003473	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
557598003474	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
557598003475	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
557598003476	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
557598003477	SLBB domain; Region: SLBB; pfam10531
557598003478	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
557598003479	electron transport complex protein RnfB; Provisional; Region: PRK05113
557598003480	Putative Fe-S cluster; Region: FeS; pfam04060
557598003481	4Fe-4S binding domain; Region: Fer4; cl02805
557598003482	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
557598003483	acetyl-CoA synthetase; Provisional; Region: PRK00174
557598003484	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
557598003485	AMP-binding enzyme; Region: AMP-binding; cl15778
557598003486	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598003487	Sodium:solute symporter family; Region: SSF; cl00456
557598003488	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
557598003489	Protein of unknown function, DUF485; Region: DUF485; cl01231
557598003490	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598003491	Helix-turn-helix domains; Region: HTH; cl00088
557598003492	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
557598003493	dimerization interface [polypeptide binding]; other site
557598003494	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
557598003495	putative active site [active]
557598003496	putative metal binding site [ion binding]; other site
557598003497	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
557598003498	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
557598003499	substrate binding site [chemical binding]; other site
557598003500	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
557598003501	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
557598003502	substrate binding site [chemical binding]; other site
557598003503	Protein of unknown function, DUF486; Region: DUF486; cl01236
557598003504	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
557598003505	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
557598003506	AsmA-like C-terminal region; Region: AsmA_2; cl15864
557598003507	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
557598003508	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
557598003509	Nitrogen regulatory protein P-II; Region: P-II; cl00412
557598003510	Nitrogen regulatory protein P-II; Region: P-II; smart00938
557598003511	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
557598003512	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
557598003513	dimerization interface [polypeptide binding]; other site
557598003514	ATP binding site [chemical binding]; other site
557598003515	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
557598003516	dimerization interface [polypeptide binding]; other site
557598003517	ATP binding site [chemical binding]; other site
557598003518	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
557598003519	putative active site [active]
557598003520	catalytic triad [active]
557598003521	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
557598003522	hydrophobic ligand binding site; other site
557598003523	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
557598003524	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
557598003525	heme binding site [chemical binding]; other site
557598003526	ferroxidase pore; other site
557598003527	ferroxidase diiron center [ion binding]; other site
557598003528	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
557598003529	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
557598003530	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
557598003531	putative active site [active]
557598003532	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003533	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
557598003534	tartrate dehydrogenase; Provisional; Region: PRK08194
557598003535	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
557598003536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003537	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
557598003538	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
557598003539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003540	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
557598003541	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
557598003542	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
557598003543	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
557598003544	dimerization interface 3.5A [polypeptide binding]; other site
557598003545	active site
557598003546	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
557598003547	active site
557598003548	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
557598003549	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
557598003550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598003551	catalytic residue [active]
557598003552	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
557598003553	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
557598003554	substrate binding site [chemical binding]; other site
557598003555	active site
557598003556	catalytic residues [active]
557598003557	heterodimer interface [polypeptide binding]; other site
557598003558	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
557598003559	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
557598003560	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
557598003561	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421
557598003562	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
557598003563	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598003564	ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
557598003565	Walker A/P-loop; other site
557598003566	ATP binding site [chemical binding]; other site
557598003567	Q-loop/lid; other site
557598003568	ABC transporter signature motif; other site
557598003569	Walker B; other site
557598003570	D-loop; other site
557598003571	H-loop/switch region; other site
557598003572	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
557598003573	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003574	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003575	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
557598003576	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598003577	DNA binding residues [nucleotide binding]
557598003578	dimerization interface [polypeptide binding]; other site
557598003579	Sodium:solute symporter family; Region: SSF; cl00456
557598003580	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
557598003581	Protein of unknown function, DUF485; Region: DUF485; cl01231
557598003582	cysteine synthase B; Region: cysM; TIGR01138
557598003583	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
557598003584	dimer interface [polypeptide binding]; other site
557598003585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598003586	catalytic residue [active]
557598003587	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
557598003588	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
557598003589	tetramer interface [polypeptide binding]; other site
557598003590	heme binding pocket [chemical binding]; other site
557598003591	NADPH binding site [chemical binding]; other site
557598003592	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
557598003593	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
557598003594	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003595	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003596	ABC transporter; Region: ABC_tran_2; pfam12848
557598003597	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598003598	NAD synthetase; Provisional; Region: PRK13981
557598003599	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
557598003600	multimer interface [polypeptide binding]; other site
557598003601	active site
557598003602	catalytic triad [active]
557598003603	protein interface 1 [polypeptide binding]; other site
557598003604	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
557598003605	homodimer interface [polypeptide binding]; other site
557598003606	NAD binding pocket [chemical binding]; other site
557598003607	ATP binding pocket [chemical binding]; other site
557598003608	Mg binding site [ion binding]; other site
557598003609	active-site loop [active]
557598003610	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
557598003611	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
557598003612	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
557598003613	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598003614	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598003615	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
557598003616	nucleophilic elbow; other site
557598003617	catalytic triad; other site
557598003618	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
557598003619	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
557598003620	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
557598003621	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
557598003622	Integrase core domain; Region: rve_3; cl15866
557598003623	Helix-turn-helix domains; Region: HTH; cl00088
557598003624	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
557598003625	TIGR03549 family protein; Region: TIGR03549
557598003626	OsmC-like protein; Region: OsmC; cl00767
557598003627	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
557598003628	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
557598003629	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003630	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003631	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
557598003632	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
557598003633	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
557598003634	Protein export membrane protein; Region: SecD_SecF; cl14618
557598003635	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598003636	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
557598003637	YdjC-like protein; Region: YdjC; cl01344
557598003638	potential protein location (hypothetical protein) that overlaps protein (cellobiose phosphorylase)
557598003639	GtrA-like protein; Region: GtrA; cl00971
557598003640	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
557598003641	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
557598003642	Ligand binding site; other site
557598003643	Putative Catalytic site; other site
557598003644	DXD motif; other site
557598003645	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
557598003646	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
557598003647	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
557598003648	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
557598003649	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598003650	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
557598003651	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598003652	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
557598003653	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
557598003654	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
557598003655	dimer interface [polypeptide binding]; other site
557598003656	active site
557598003657	heme binding site [chemical binding]; other site
557598003658	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
557598003659	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
557598003660	membrane protein FdrA; Validated; Region: PRK06091
557598003661	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
557598003662	membrane protein FdrA; Validated; Region: PRK06091
557598003663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003664	CoA-ligase; Region: Ligase_CoA; cl02894
557598003665	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
557598003666	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
557598003667	Helix-turn-helix domains; Region: HTH; cl00088
557598003668	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
557598003669	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598003670	dimerization interface [polypeptide binding]; other site
557598003671	Isochorismatase family; Region: Isochorismatase; pfam00857
557598003672	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
557598003673	catalytic triad [active]
557598003674	conserved cis-peptide bond; other site
557598003675	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
557598003676	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598003677	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598003678	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
557598003679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003680	NAD(P) binding site [chemical binding]; other site
557598003681	active site
557598003682	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792
557598003683	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
557598003684	short chain dehydrogenase; Provisional; Region: PRK08251
557598003685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003686	NAD(P) binding site [chemical binding]; other site
557598003687	active site
557598003688	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
557598003689	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
557598003690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598003691	S-adenosylmethionine binding site [chemical binding]; other site
557598003692	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
557598003693	Uncharacterized conserved protein [Function unknown]; Region: COG3496
557598003694	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
557598003695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003696	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
557598003697	Helix-turn-helix domains; Region: HTH; cl00088
557598003698	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
557598003699	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
557598003700	putative sugar binding sites [chemical binding]; other site
557598003701	Q-X-W motif; other site
557598003702	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
557598003703	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
557598003704	putative sugar binding sites [chemical binding]; other site
557598003705	Q-X-W motif; other site
557598003706	Helix-turn-helix domains; Region: HTH; cl00088
557598003707	transcriptional regulator SlyA; Provisional; Region: PRK03573
557598003708	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
557598003709	Fusaric acid resistance protein family; Region: FUSC; pfam04632
557598003710	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
557598003711	active site
557598003712	aspartate aminotransferase; Provisional; Region: PRK05764
557598003713	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598003714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598003715	homodimer interface [polypeptide binding]; other site
557598003716	catalytic residue [active]
557598003717	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
557598003718	Cytochrome C'; Region: Cytochrom_C_2; cl01610
557598003719	Predicted membrane protein [Function unknown]; Region: COG3671
557598003720	Helix-turn-helix domains; Region: HTH; cl00088
557598003721	metal binding site 2 [ion binding]; metal-binding site
557598003722	putative DNA binding helix; other site
557598003723	metal binding site 1 [ion binding]; metal-binding site
557598003724	dimer interface [polypeptide binding]; other site
557598003725	structural Zn2+ binding site [ion binding]; other site
557598003726	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
557598003727	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003728	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
557598003729	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
557598003730	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
557598003731	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
557598003732	ABC-ATPase subunit  interface; other site
557598003733	dimer interface [polypeptide binding]; other site
557598003734	putative PBP binding regions; other site
557598003735	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
557598003736	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
557598003737	metal binding site [ion binding]; metal-binding site
557598003738	Predicted permeases [General function prediction only]; Region: RarD; COG2962
557598003739	EamA-like transporter family; Region: EamA; cl01037
557598003740	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
557598003741	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
557598003742	lysophospholipase L2; Provisional; Region: PRK10749
557598003743	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
557598003744	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
557598003745	Domain of unknown function (DUF932); Region: DUF932; cl12129
557598003746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598003747	active site
557598003748	phosphorylation site [posttranslational modification]
557598003749	intermolecular recognition site; other site
557598003750	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598003751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598003752	active site
557598003753	phosphorylation site [posttranslational modification]
557598003754	intermolecular recognition site; other site
557598003755	dimerization interface [polypeptide binding]; other site
557598003756	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
557598003757	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598003758	dimer interface [polypeptide binding]; other site
557598003759	putative CheW interface [polypeptide binding]; other site
557598003760	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598003761	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
557598003762	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
557598003763	gating phenylalanine in ion channel; other site
557598003764	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
557598003765	Helix-turn-helix domains; Region: HTH; cl00088
557598003766	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
557598003767	putative dimerization interface [polypeptide binding]; other site
557598003768	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
557598003769	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
557598003770	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
557598003771	diiron binding motif [ion binding]; other site
557598003772	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
557598003773	dimer interface [polypeptide binding]; other site
557598003774	substrate binding site [chemical binding]; other site
557598003775	metal binding sites [ion binding]; metal-binding site
557598003776	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598003777	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598003778	dimer interface [polypeptide binding]; other site
557598003779	putative CheW interface [polypeptide binding]; other site
557598003780	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
557598003781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598003782	putative substrate translocation pore; other site
557598003783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598003784	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
557598003785	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003786	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598003787	Helix-turn-helix domains; Region: HTH; cl00088
557598003788	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
557598003789	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
557598003790	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
557598003791	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
557598003792	metal-binding site [ion binding]
557598003793	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598003794	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598003795	GTPase RsgA; Reviewed; Region: PRK00098
557598003796	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
557598003797	RNA binding site [nucleotide binding]; other site
557598003798	homodimer interface [polypeptide binding]; other site
557598003799	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
557598003800	GTPase/Zn-binding domain interface [polypeptide binding]; other site
557598003801	GTP/Mg2+ binding site [chemical binding]; other site
557598003802	G4 box; other site
557598003803	G5 box; other site
557598003804	G1 box; other site
557598003805	Switch I region; other site
557598003806	G2 box; other site
557598003807	G3 box; other site
557598003808	Switch II region; other site
557598003809	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
557598003810	aromatic arch; other site
557598003811	DCoH dimer interaction site [polypeptide binding]; other site
557598003812	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
557598003813	DCoH tetramer interaction site [polypeptide binding]; other site
557598003814	substrate binding site [chemical binding]; other site
557598003815	Peptidase family M48; Region: Peptidase_M48; cl12018
557598003816	MarC family integral membrane protein; Region: MarC; cl00919
557598003817	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
557598003818	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
557598003819	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
557598003820	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
557598003821	Membrane transport protein; Region: Mem_trans; cl09117
557598003822	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
557598003823	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
557598003824	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
557598003825	generic binding surface I; other site
557598003826	generic binding surface II; other site
557598003827	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
557598003828	Malic enzyme, N-terminal domain; Region: malic; pfam00390
557598003829	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
557598003830	putative NAD(P) binding site [chemical binding]; other site
557598003831	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
557598003832	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598003833	DctM-like transporters; Region: DctM; pfam06808
557598003834	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
557598003835	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
557598003836	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
557598003837	PAS domain S-box; Region: sensory_box; TIGR00229
557598003838	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598003839	putative active site [active]
557598003840	heme pocket [chemical binding]; other site
557598003841	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
557598003842	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598003843	dimer interface [polypeptide binding]; other site
557598003844	phosphorylation site [posttranslational modification]
557598003845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598003846	ATP binding site [chemical binding]; other site
557598003847	Mg2+ binding site [ion binding]; other site
557598003848	G-X-G motif; other site
557598003849	poly(A) polymerase; Region: pcnB; TIGR01942
557598003850	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
557598003851	active site
557598003852	NTP binding site [chemical binding]; other site
557598003853	metal binding triad [ion binding]; metal-binding site
557598003854	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
557598003855	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
557598003856	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
557598003857	catalytic center binding site [active]
557598003858	ATP binding site [chemical binding]; other site
557598003859	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
557598003860	oligomerization interface [polypeptide binding]; other site
557598003861	active site
557598003862	metal binding site [ion binding]; metal-binding site
557598003863	pantoate--beta-alanine ligase; Region: panC; TIGR00018
557598003864	Pantoate-beta-alanine ligase; Region: PanC; cd00560
557598003865	active site
557598003866	ATP-binding site [chemical binding]; other site
557598003867	pantoate-binding site; other site
557598003868	HXXH motif; other site
557598003869	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
557598003870	tetramerization interface [polypeptide binding]; other site
557598003871	active site
557598003872	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
557598003873	putative transporter; Provisional; Region: PRK11660
557598003874	Sulfate transporter family; Region: Sulfate_transp; cl15842
557598003875	Sulfate transporter family; Region: Sulfate_transp; cl15842
557598003876	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
557598003877	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
557598003878	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598003879	active site
557598003880	HIGH motif; other site
557598003881	nucleotide binding site [chemical binding]; other site
557598003882	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
557598003883	KMSKS motif; other site
557598003884	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
557598003885	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
557598003886	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
557598003887	active site
557598003888	HIGH motif; other site
557598003889	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
557598003890	KMSKS motif; other site
557598003891	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
557598003892	tRNA binding surface [nucleotide binding]; other site
557598003893	anticodon binding site; other site
557598003894	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
557598003895	Cytochrome C'; Region: Cytochrom_C_2; cl01610
557598003896	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598003897	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
557598003898	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598003899	Walker A/P-loop; other site
557598003900	ATP binding site [chemical binding]; other site
557598003901	Q-loop/lid; other site
557598003902	ABC transporter signature motif; other site
557598003903	Walker B; other site
557598003904	D-loop; other site
557598003905	H-loop/switch region; other site
557598003906	PII uridylyl-transferase; Provisional; Region: PRK03059
557598003907	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
557598003908	metal binding triad; other site
557598003909	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
557598003910	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
557598003911	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
557598003912	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
557598003913	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
557598003914	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
557598003915	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
557598003916	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
557598003917	multifunctional aminopeptidase A; Provisional; Region: PRK00913
557598003918	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
557598003919	interface (dimer of trimers) [polypeptide binding]; other site
557598003920	Substrate-binding/catalytic site; other site
557598003921	Zn-binding sites [ion binding]; other site
557598003922	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
557598003923	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
557598003924	Staphylococcal nuclease homologues; Region: SNc; smart00318
557598003925	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
557598003926	Catalytic site; other site
557598003927	hypothetical protein; Provisional; Region: PRK09936
557598003928	bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782
557598003929	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
557598003930	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
557598003931	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
557598003932	active site
557598003933	homodimer interface [polypeptide binding]; other site
557598003934	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
557598003935	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598003936	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
557598003937	Protein of unknown function (DUF520); Region: DUF520; cl00723
557598003938	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598003939	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
557598003940	Protein export membrane protein; Region: SecD_SecF; cl14618
557598003941	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598003942	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003943	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598003944	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
557598003945	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
557598003946	Walker A/P-loop; other site
557598003947	ATP binding site [chemical binding]; other site
557598003948	Q-loop/lid; other site
557598003949	ABC transporter signature motif; other site
557598003950	Walker B; other site
557598003951	D-loop; other site
557598003952	H-loop/switch region; other site
557598003953	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
557598003954	ABC-ATPase subunit  interface; other site
557598003955	dimer interface [polypeptide binding]; other site
557598003956	putative PBP binding regions; other site
557598003957	dihydrodipicolinate reductase; Provisional; Region: PRK00048
557598003958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598003959	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
557598003960	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
557598003961	ferric uptake regulator; Provisional; Region: fur; PRK09462
557598003962	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
557598003963	metal binding site 2 [ion binding]; metal-binding site
557598003964	putative DNA binding helix; other site
557598003965	metal binding site 1 [ion binding]; metal-binding site
557598003966	dimer interface [polypeptide binding]; other site
557598003967	structural Zn2+ binding site [ion binding]; other site
557598003968	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598003969	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
557598003970	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
557598003971	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598003972	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
557598003973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598003974	S-adenosylmethionine binding site [chemical binding]; other site
557598003975	Uncharacterized conserved protein [Function unknown]; Region: COG3760
557598003976	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
557598003977	putative deacylase active site [active]
557598003978	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
557598003979	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
557598003980	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
557598003981	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
557598003982	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
557598003983	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
557598003984	SLBB domain; Region: SLBB; pfam10531
557598003985	4Fe-4S binding domain; Region: Fer4; cl02805
557598003986	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
557598003987	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
557598003988	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
557598003989	4Fe-4S binding domain; Region: Fer4; cl02805
557598003990	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
557598003991	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
557598003992	TPP-binding site [chemical binding]; other site
557598003993	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
557598003994	dimer interface [polypeptide binding]; other site
557598003995	PYR/PP interface [polypeptide binding]; other site
557598003996	TPP binding site [chemical binding]; other site
557598003997	substrate binding site [chemical binding]; other site
557598003998	ferredoxin; Validated; Region: PRK07118
557598003999	Putative Fe-S cluster; Region: FeS; pfam04060
557598004000	4Fe-4S binding domain; Region: Fer4; cl02805
557598004001	arginine decarboxylase; Provisional; Region: PRK05354
557598004002	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
557598004003	dimer interface [polypeptide binding]; other site
557598004004	active site
557598004005	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
557598004006	catalytic residues [active]
557598004007	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
557598004008	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
557598004009	ligand binding site [chemical binding]; other site
557598004010	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
557598004011	active site
557598004012	ribulose/triose binding site [chemical binding]; other site
557598004013	phosphate binding site [ion binding]; other site
557598004014	substrate (anthranilate) binding pocket [chemical binding]; other site
557598004015	product (indole) binding pocket [chemical binding]; other site
557598004016	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
557598004017	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
557598004018	MPT binding site; other site
557598004019	trimer interface [polypeptide binding]; other site
557598004020	Protein of unknown function (DUF615); Region: DUF615; cl01147
557598004021	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
557598004022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598004023	FeS/SAM binding site; other site
557598004024	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598004025	Ligand Binding Site [chemical binding]; other site
557598004026	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
557598004027	active site
557598004028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598004029	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
557598004030	Walker A motif; other site
557598004031	ATP binding site [chemical binding]; other site
557598004032	Walker B motif; other site
557598004033	arginine finger; other site
557598004034	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
557598004035	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
557598004036	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
557598004037	DNA binding residues [nucleotide binding]
557598004038	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
557598004039	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
557598004040	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
557598004041	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
557598004042	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
557598004043	protein binding site [polypeptide binding]; other site
557598004044	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
557598004045	protein binding site [polypeptide binding]; other site
557598004046	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
557598004047	GTP-binding protein LepA; Provisional; Region: PRK05433
557598004048	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
557598004049	G1 box; other site
557598004050	putative GEF interaction site [polypeptide binding]; other site
557598004051	GTP/Mg2+ binding site [chemical binding]; other site
557598004052	Switch I region; other site
557598004053	G2 box; other site
557598004054	G3 box; other site
557598004055	Switch II region; other site
557598004056	G4 box; other site
557598004057	G5 box; other site
557598004058	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
557598004059	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
557598004060	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
557598004061	signal peptidase I; Provisional; Region: PRK10861
557598004062	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
557598004063	Catalytic site [active]
557598004064	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
557598004065	ribonuclease III; Reviewed; Region: rnc; PRK00102
557598004066	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
557598004067	dimerization interface [polypeptide binding]; other site
557598004068	active site
557598004069	metal binding site [ion binding]; metal-binding site
557598004070	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
557598004071	dsRNA binding site [nucleotide binding]; other site
557598004072	GTPase Era; Reviewed; Region: era; PRK00089
557598004073	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
557598004074	G1 box; other site
557598004075	GTP/Mg2+ binding site [chemical binding]; other site
557598004076	Switch I region; other site
557598004077	G2 box; other site
557598004078	Switch II region; other site
557598004079	G3 box; other site
557598004080	G4 box; other site
557598004081	G5 box; other site
557598004082	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
557598004083	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
557598004084	Recombination protein O N terminal; Region: RecO_N; cl15812
557598004085	Recombination protein O C terminal; Region: RecO_C; pfam02565
557598004086	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
557598004087	active site
557598004088	hydrophilic channel; other site
557598004089	dimerization interface [polypeptide binding]; other site
557598004090	catalytic residues [active]
557598004091	active site lid [active]
557598004092	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
557598004093	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
557598004094	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
557598004095	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598004096	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598004097	dimer interface [polypeptide binding]; other site
557598004098	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598004099	putative CheW interface [polypeptide binding]; other site
557598004100	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
557598004101	Helix-turn-helix domains; Region: HTH; cl00088
557598004102	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
557598004103	putative dimerization interface [polypeptide binding]; other site
557598004104	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
557598004105	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
557598004106	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
557598004107	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
557598004108	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
557598004109	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
557598004110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598004111	active site
557598004112	dimerization interface [polypeptide binding]; other site
557598004113	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598004114	DNA binding residues [nucleotide binding]
557598004115	dimerization interface [polypeptide binding]; other site
557598004116	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
557598004117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598004118	dimer interface [polypeptide binding]; other site
557598004119	phosphorylation site [posttranslational modification]
557598004120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598004121	ATP binding site [chemical binding]; other site
557598004122	Mg2+ binding site [ion binding]; other site
557598004123	G-X-G motif; other site
557598004124	tetrathionate reductase subunit A; Provisional; Region: PRK14991
557598004125	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
557598004126	putative [Fe4-S4] binding site [ion binding]; other site
557598004127	putative molybdopterin cofactor binding site [chemical binding]; other site
557598004128	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
557598004129	putative molybdopterin cofactor binding site; other site
557598004130	Polysulphide reductase, NrfD; Region: NrfD; cl01295
557598004131	Polysulphide reductase, NrfD; Region: NrfD; cl01295
557598004132	tetrathionate reductase subunit B; Provisional; Region: PRK14993
557598004133	4Fe-4S binding domain; Region: Fer4; cl02805
557598004134	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
557598004135	dimer interface [polypeptide binding]; other site
557598004136	ssDNA binding site [nucleotide binding]; other site
557598004137	tetramer (dimer of dimers) interface [polypeptide binding]; other site
557598004138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
557598004139	Smr domain; Region: Smr; cl02619
557598004140	thioredoxin reductase; Provisional; Region: PRK10262
557598004141	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
557598004142	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
557598004143	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
557598004144	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
557598004145	motif 1; other site
557598004146	active site
557598004147	motif 2; other site
557598004148	motif 3; other site
557598004149	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
557598004150	DHHA1 domain; Region: DHHA1; pfam02272
557598004151	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
557598004152	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
557598004153	putative NAD(P) binding site [chemical binding]; other site
557598004154	active site
557598004155	lytic murein transglycosylase; Provisional; Region: PRK11619
557598004156	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
557598004157	N-acetyl-D-glucosamine binding site [chemical binding]; other site
557598004158	catalytic residue [active]
557598004159	Cation transport protein; Region: TrkH; cl10514
557598004160	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
557598004161	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
557598004162	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004163	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
557598004164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004165	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
557598004166	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
557598004167	catalytic triad [active]
557598004168	dimer interface [polypeptide binding]; other site
557598004169	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
557598004170	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
557598004171	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
557598004172	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
557598004173	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
557598004174	active site
557598004175	metal binding site [ion binding]; metal-binding site
557598004176	substrate binding site [chemical binding]; other site
557598004177	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
557598004178	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
557598004179	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
557598004180	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
557598004181	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
557598004182	glutamine binding [chemical binding]; other site
557598004183	catalytic triad [active]
557598004184	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
557598004185	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
557598004186	dimer interface [polypeptide binding]; other site
557598004187	ssDNA binding site [nucleotide binding]; other site
557598004188	tetramer (dimer of dimers) interface [polypeptide binding]; other site
557598004189	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
557598004190	RecT family; Region: RecT; cl04285
557598004191	aminotransferase; Validated; Region: PRK07777
557598004192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598004193	non-specific DNA binding site [nucleotide binding]; other site
557598004194	salt bridge; other site
557598004195	sequence-specific DNA binding site [nucleotide binding]; other site
557598004196	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
557598004197	Catalytic site [active]
557598004198	replicative DNA helicase; Region: DnaB; TIGR00665
557598004199	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
557598004200	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004201	Walker A motif; other site
557598004202	ATP binding site [chemical binding]; other site
557598004203	Walker B motif; other site
557598004204	NinB protein; Region: NinB; cl14671
557598004205	Protein of unknown function (DUF968); Region: DUF968; pfam06147
557598004206	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
557598004207	hypothetical protein; Region: PHA00675
557598004208	Terminase small subunit; Region: Terminase_2; cl01513
557598004209	potential frameshift: common BLAST hit: gi|215487825|ref|YP_002330256.1| terminase, large subunit
557598004210	hypothetical protein; Region: PHA00675
557598004211	HsdM N-terminal domain; Region: HsdM_N; pfam12161
557598004212	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
557598004213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004214	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
557598004215	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
557598004216	Protein of unknown function DUF91; Region: DUF91; cl00709
557598004217	Uncharacterized conserved protein [Function unknown]; Region: COG3586
557598004218	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
557598004219	active site
557598004220	NTP binding site [chemical binding]; other site
557598004221	metal binding triad [ion binding]; metal-binding site
557598004222	antibiotic binding site [chemical binding]; other site
557598004223	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
557598004224	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
557598004225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598004226	ATP binding site [chemical binding]; other site
557598004227	putative Mg++ binding site [ion binding]; other site
557598004228	Domain of unknown function (DUF927); Region: DUF927; cl12098
557598004229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
557598004230	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
557598004231	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
557598004232	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
557598004233	Helix-turn-helix domain; Region: HTH_39; pfam14090
557598004234	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
557598004235	integrase; Provisional; Region: PRK09692
557598004236	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
557598004237	active site
557598004238	Int/Topo IB signature motif; other site
557598004239	acyl-CoA synthetase; Validated; Region: PRK08316
557598004240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
557598004241	Coenzyme A binding pocket [chemical binding]; other site
557598004242	hypothetical protein; Region: PHA00671
557598004243	Bacteriophage head to tail connecting protein; Region: Head-tail_con; cl10251
557598004244	putative protease; Region: PHA00666
557598004245	major capsid protein; Region: PHA00665
557598004246	hypothetical protein; Region: PHA00664
557598004247	hypothetical protein; Region: PHA00662
557598004248	hypothetical protein; Region: PHA00661
557598004249	hypothetical protein; Region: PHA00661
557598004250	Predicted transcriptional regulator [Transcription]; Region: COG2944
557598004251	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598004252	sequence-specific DNA binding site [nucleotide binding]; other site
557598004253	salt bridge; other site
557598004254	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
557598004255	hypothetical protein; Region: PHA00660
557598004256	putative lysin; Region: PHA00658
557598004257	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
557598004258	crystallin beta/gamma motif-containing protein; Region: PHA00657
557598004259	crystallin beta/gamma motif-containing protein; Region: PHA00657
557598004260	crystallin beta/gamma motif-containing protein; Region: PHA00657
557598004261	hypothetical protein; Provisional; Region: PHA02515
557598004262	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598004263	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
557598004264	catalytic residues [active]
557598004265	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
557598004266	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
557598004267	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004268	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598004269	nucleotide binding region [chemical binding]; other site
557598004270	ATP-binding site [chemical binding]; other site
557598004271	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
557598004272	peptide synthase; Provisional; Region: PRK12316
557598004273	integrase; Provisional; Region: PRK09692
557598004274	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
557598004275	active site
557598004276	Int/Topo IB signature motif; other site
557598004277	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
557598004278	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
557598004279	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598004280	K+-transporting ATPase, c chain; Region: KdpC; cl00944
557598004281	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
557598004282	sensor protein KdpD; Provisional; Region: PRK10490
557598004283	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
557598004284	Ligand Binding Site [chemical binding]; other site
557598004285	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
557598004286	GAF domain; Region: GAF; cl15785
557598004287	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598004288	dimer interface [polypeptide binding]; other site
557598004289	phosphorylation site [posttranslational modification]
557598004290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598004291	ATP binding site [chemical binding]; other site
557598004292	Mg2+ binding site [ion binding]; other site
557598004293	G-X-G motif; other site
557598004294	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
557598004295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598004296	active site
557598004297	phosphorylation site [posttranslational modification]
557598004298	intermolecular recognition site; other site
557598004299	dimerization interface [polypeptide binding]; other site
557598004300	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598004301	DNA binding site [nucleotide binding]
557598004302	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
557598004303	Catalytic site [active]
557598004304	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
557598004305	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
557598004306	active site
557598004307	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
557598004308	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004309	Walker A/P-loop; other site
557598004310	ATP binding site [chemical binding]; other site
557598004311	Q-loop/lid; other site
557598004312	ABC transporter signature motif; other site
557598004313	Walker B; other site
557598004314	D-loop; other site
557598004315	H-loop/switch region; other site
557598004316	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
557598004317	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
557598004318	Walker A/P-loop; other site
557598004319	ATP binding site [chemical binding]; other site
557598004320	Q-loop/lid; other site
557598004321	ABC transporter signature motif; other site
557598004322	Walker B; other site
557598004323	D-loop; other site
557598004324	H-loop/switch region; other site
557598004325	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
557598004326	Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457
557598004327	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456
557598004328	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455
557598004329	Phosphonate metabolism protein PhnG; Region: PhnG; cl01454
557598004330	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
557598004331	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598004332	DNA-binding site [nucleotide binding]; DNA binding site
557598004333	UTRA domain; Region: UTRA; cl01230
557598004334	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
557598004335	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004336	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598004337	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
557598004338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004339	Walker A/P-loop; other site
557598004340	ATP binding site [chemical binding]; other site
557598004341	Q-loop/lid; other site
557598004342	ABC transporter signature motif; other site
557598004343	Walker B; other site
557598004344	D-loop; other site
557598004345	H-loop/switch region; other site
557598004346	TOBE domain; Region: TOBE_2; cl01440
557598004347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598004348	dimer interface [polypeptide binding]; other site
557598004349	conserved gate region; other site
557598004350	putative PBP binding loops; other site
557598004351	ABC-ATPase subunit interface; other site
557598004352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598004353	dimer interface [polypeptide binding]; other site
557598004354	conserved gate region; other site
557598004355	putative PBP binding loops; other site
557598004356	ABC-ATPase subunit interface; other site
557598004357	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
557598004358	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
557598004359	active site
557598004360	dimer interface [polypeptide binding]; other site
557598004361	effector binding site; other site
557598004362	xanthine permease; Region: pbuX; TIGR03173
557598004363	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
557598004364	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
557598004365	Protein of unknown function (DUF423); Region: DUF423; cl01008
557598004366	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598004367	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598004368	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598004369	dimer interface [polypeptide binding]; other site
557598004370	putative CheW interface [polypeptide binding]; other site
557598004371	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
557598004372	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
557598004373	dimerization domain [polypeptide binding]; other site
557598004374	dimer interface [polypeptide binding]; other site
557598004375	catalytic residues [active]
557598004376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598004377	Major Facilitator Superfamily; Region: MFS_1; pfam07690
557598004378	putative substrate translocation pore; other site
557598004379	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
557598004380	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
557598004381	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
557598004382	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
557598004383	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
557598004384	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
557598004385	active site
557598004386	metal binding site [ion binding]; metal-binding site
557598004387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
557598004388	Helix-turn-helix domains; Region: HTH; cl00088
557598004389	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598004390	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
557598004391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004392	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
557598004393	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598004394	substrate binding site [chemical binding]; other site
557598004395	oxyanion hole (OAH) forming residues; other site
557598004396	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
557598004397	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
557598004398	dimer interface [polypeptide binding]; other site
557598004399	active site
557598004400	OsmC-like protein; Region: OsmC; cl00767
557598004401	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
557598004402	NeuB family; Region: NeuB; cl00496
557598004403	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
557598004404	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
557598004405	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
557598004406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598004407	dimer interface [polypeptide binding]; other site
557598004408	conserved gate region; other site
557598004409	putative PBP binding loops; other site
557598004410	ABC-ATPase subunit interface; other site
557598004411	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
557598004412	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
557598004413	substrate binding pocket [chemical binding]; other site
557598004414	membrane-bound complex binding site; other site
557598004415	hinge residues; other site
557598004416	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598004417	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598004418	dimer interface [polypeptide binding]; other site
557598004419	putative CheW interface [polypeptide binding]; other site
557598004420	potential frameshift: common BLAST hit: gi|209397184|ref|YP_002273588.1| phage integrase family protein
557598004421	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598004422	active site
557598004423	DNA binding site [nucleotide binding]
557598004424	Int/Topo IB signature motif; other site
557598004425	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
557598004426	Moco binding site; other site
557598004427	metal coordination site [ion binding]; other site
557598004428	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
557598004429	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
557598004430	catalytic residues [active]
557598004431	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598004432	Phage Tail Collar Domain; Region: Collar; pfam07484
557598004433	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598004434	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
557598004435	Baseplate J-like protein; Region: Baseplate_J; cl01294
557598004436	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
557598004437	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598004438	Phage Tail Protein X; Region: Phage_tail_X; cl02088
557598004439	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
557598004440	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
557598004441	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
557598004442	KilA-N domain; Region: KilA-N; pfam04383
557598004443	Phage tail tube protein FII; Region: Phage_tube; cl01390
557598004444	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
557598004445	Gp37 protein; Region: Gp37; pfam09646
557598004446	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
557598004447	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
557598004448	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
557598004449	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
557598004450	tandem repeat interface [polypeptide binding]; other site
557598004451	oligomer interface [polypeptide binding]; other site
557598004452	active site residues [active]
557598004453	FOG: CBS domain [General function prediction only]; Region: COG0517
557598004454	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
557598004455	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
557598004456	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
557598004457	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
557598004458	gpW; Region: gpW; pfam02831
557598004459	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448
557598004460	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
557598004461	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
557598004462	BRO family, N-terminal domain; Region: Bro-N; cl10591
557598004463	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
557598004464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598004465	non-specific DNA binding site [nucleotide binding]; other site
557598004466	salt bridge; other site
557598004467	sequence-specific DNA binding site [nucleotide binding]; other site
557598004468	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004469	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
557598004470	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
557598004471	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
557598004472	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598004473	active site
557598004474	DNA binding site [nucleotide binding]
557598004475	Int/Topo IB signature motif; other site
557598004476	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
557598004477	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
557598004478	FMN binding site [chemical binding]; other site
557598004479	active site
557598004480	catalytic residues [active]
557598004481	substrate binding site [chemical binding]; other site
557598004482	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
557598004483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598004484	BCCT family transporter; Region: BCCT; cl00569
557598004485	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
557598004486	catalytic residues [active]
557598004487	transcription termination factor Rho; Provisional; Region: rho; PRK09376
557598004488	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
557598004489	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
557598004490	RNA binding site [nucleotide binding]; other site
557598004491	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
557598004492	multimer interface [polypeptide binding]; other site
557598004493	Walker A motif; other site
557598004494	ATP binding site [chemical binding]; other site
557598004495	Walker B motif; other site
557598004496	UPF0126 domain; Region: UPF0126; pfam03458
557598004497	Predicted membrane protein [Function unknown]; Region: COG2860
557598004498	UPF0126 domain; Region: UPF0126; pfam03458
557598004499	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
557598004500	putative active site [active]
557598004501	putative CoA binding site [chemical binding]; other site
557598004502	nudix motif; other site
557598004503	metal binding site [ion binding]; metal-binding site
557598004504	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
557598004505	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
557598004506	Active Sites [active]
557598004507	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
557598004508	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
557598004509	CysD dimerization site [polypeptide binding]; other site
557598004510	G1 box; other site
557598004511	putative GEF interaction site [polypeptide binding]; other site
557598004512	GTP/Mg2+ binding site [chemical binding]; other site
557598004513	Switch I region; other site
557598004514	G2 box; other site
557598004515	G3 box; other site
557598004516	Switch II region; other site
557598004517	G4 box; other site
557598004518	G5 box; other site
557598004519	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
557598004520	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
557598004521	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
557598004522	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
557598004523	ATP binding site [chemical binding]; other site
557598004524	Mg++ binding site [ion binding]; other site
557598004525	motif III; other site
557598004526	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598004527	nucleotide binding region [chemical binding]; other site
557598004528	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
557598004529	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598004530	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
557598004531	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598004532	BolA-like protein; Region: BolA; cl00386
557598004533	YCII-related domain; Region: YCII; cl00999
557598004534	Intracellular septation protein A; Region: IspA; cl01098
557598004535	META domain; Region: META; cl01245
557598004536	META domain; Region: META; cl01245
557598004537	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
557598004538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598004539	PAS domain; Region: PAS_9; pfam13426
557598004540	putative active site [active]
557598004541	heme pocket [chemical binding]; other site
557598004542	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
557598004543	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598004544	dimer interface [polypeptide binding]; other site
557598004545	putative CheW interface [polypeptide binding]; other site
557598004546	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
557598004547	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
557598004548	putative catalytic site [active]
557598004549	putative metal binding site [ion binding]; other site
557598004550	putative phosphate binding site [ion binding]; other site
557598004551	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
557598004552	putative active site [active]
557598004553	catalytic site [active]
557598004554	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
557598004555	putative active site [active]
557598004556	catalytic site [active]
557598004557	hypothetical protein; Provisional; Region: PRK11820
557598004558	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
557598004559	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
557598004560	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
557598004561	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
557598004562	substrate binding site [chemical binding]; other site
557598004563	dimer interface [polypeptide binding]; other site
557598004564	ATP binding site [chemical binding]; other site
557598004565	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
557598004566	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
557598004567	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
557598004568	Walker A/P-loop; other site
557598004569	ATP binding site [chemical binding]; other site
557598004570	Q-loop/lid; other site
557598004571	ABC transporter signature motif; other site
557598004572	Walker B; other site
557598004573	D-loop; other site
557598004574	H-loop/switch region; other site
557598004575	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
557598004576	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
557598004577	TM-ABC transporter signature motif; other site
557598004578	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
557598004579	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
557598004580	ligand binding site [chemical binding]; other site
557598004581	dimerization interface [polypeptide binding]; other site
557598004582	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
557598004583	superoxide dismutase; Provisional; Region: PRK10543
557598004584	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
557598004585	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
557598004586	Esterase/lipase [General function prediction only]; Region: COG1647
557598004587	K+ potassium transporter; Region: K_trans; cl15781
557598004588	Cache domain; Region: Cache_1; pfam02743
557598004589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598004590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598004591	dimer interface [polypeptide binding]; other site
557598004592	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598004593	putative CheW interface [polypeptide binding]; other site
557598004594	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
557598004595	catalytic triad [active]
557598004596	conserved cis-peptide bond; other site
557598004597	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
557598004598	EamA-like transporter family; Region: EamA; cl01037
557598004599	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
557598004600	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
557598004601	conserved cys residue [active]
557598004602	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598004603	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
557598004604	multiple promoter invertase; Provisional; Region: mpi; PRK13413
557598004605	catalytic residues [active]
557598004606	catalytic nucleophile [active]
557598004607	Presynaptic Site I dimer interface [polypeptide binding]; other site
557598004608	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
557598004609	Synaptic Flat tetramer interface [polypeptide binding]; other site
557598004610	Synaptic Site I dimer interface [polypeptide binding]; other site
557598004611	DNA binding site [nucleotide binding]
557598004612	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
557598004613	DNA-binding interface [nucleotide binding]; DNA binding site
557598004614	Domain of unknown function (DUF927); Region: DUF927; cl12098
557598004615	hypothetical protein; Validated; Region: PRK07078
557598004616	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
557598004617	active site
557598004618	metal binding site [ion binding]; metal-binding site
557598004619	interdomain interaction site; other site
557598004620	Domain of unknown function (DUF927); Region: DUF927; cl12098
557598004621	KilA-N domain; Region: KilA-N; pfam04383
557598004622	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
557598004623	integrase; Provisional; Region: PRK09692
557598004624	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
557598004625	active site
557598004626	Int/Topo IB signature motif; other site
557598004627	replicative DNA helicase; Region: DnaB; TIGR00665
557598004628	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
557598004629	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
557598004630	Walker A motif; other site
557598004631	ATP binding site [chemical binding]; other site
557598004632	Walker B motif; other site
557598004633	DNA binding loops [nucleotide binding]
557598004634	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
557598004635	dimer interface [polypeptide binding]; other site
557598004636	[2Fe-2S] cluster binding site [ion binding]; other site
557598004637	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
557598004638	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598004639	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
557598004640	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
557598004641	endonuclease III; Region: ENDO3c; smart00478
557598004642	minor groove reading motif; other site
557598004643	helix-hairpin-helix signature motif; other site
557598004644	substrate binding pocket [chemical binding]; other site
557598004645	active site
557598004646	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
557598004647	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
557598004648	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
557598004649	metal binding site [ion binding]; metal-binding site
557598004650	dimer interface [polypeptide binding]; other site
557598004651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004652	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
557598004653	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
557598004654	catalytic residues [active]
557598004655	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598004656	Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945
557598004657	Phage-related protein, tail component [Function unknown]; Region: COG4733
557598004658	Putative phage tail protein; Region: Phage-tail_3; pfam13550
557598004659	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
557598004660	Phage-related minor tail protein [Function unknown]; Region: COG5281
557598004661	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
557598004662	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
557598004663	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
557598004664	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
557598004665	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
557598004666	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
557598004667	Phage tail protein; Region: Phage_tail_3; pfam08813
557598004668	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
557598004669	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
557598004670	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
557598004671	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
557598004672	oligomerization interface [polypeptide binding]; other site
557598004673	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
557598004674	Phage capsid family; Region: Phage_capsid; pfam05065
557598004675	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
557598004676	oligomer interface [polypeptide binding]; other site
557598004677	active site residues [active]
557598004678	Phage-related protein [Function unknown]; Region: COG4695; cl01923
557598004679	Phage portal protein; Region: Phage_portal; pfam04860
557598004680	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
557598004681	Phage Terminase; Region: Terminase_1; pfam03354
557598004682	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
557598004683	active site
557598004684	BRO family, N-terminal domain; Region: Bro-N; cl10591
557598004685	ORF11CD3 domain; Region: ORF11CD3; pfam10549
557598004686	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
557598004687	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
557598004688	BRO family, N-terminal domain; Region: Bro-N; cl10591
557598004689	Endodeoxyribonuclease RusA; Region: RusA; cl01885
557598004690	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
557598004691	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
557598004692	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
557598004693	Domain in histone-like proteins of HNS family; Region: HNS; cl09251
557598004694	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598004695	Walker A/P-loop; other site
557598004696	ATP binding site [chemical binding]; other site
557598004697	integrase; Provisional; Region: int; PHA02601
557598004698	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598004699	active site
557598004700	DNA binding site [nucleotide binding]
557598004701	Int/Topo IB signature motif; other site
557598004702	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
557598004703	dimer interface [polypeptide binding]; other site
557598004704	putative radical transfer pathway; other site
557598004705	diiron center [ion binding]; other site
557598004706	tyrosyl radical; other site
557598004707	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
557598004708	ATP cone domain; Region: ATP-cone; pfam03477
557598004709	ATP cone domain; Region: ATP-cone; pfam03477
557598004710	Class I ribonucleotide reductase; Region: RNR_I; cd01679
557598004711	active site
557598004712	dimer interface [polypeptide binding]; other site
557598004713	catalytic residues [active]
557598004714	effector binding site; other site
557598004715	R2 peptide binding site; other site
557598004716	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
557598004717	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
557598004718	transmembrane helices; other site
557598004719	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
557598004720	glycerate dehydrogenase; Provisional; Region: PRK06487
557598004721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004722	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
557598004723	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
557598004724	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
557598004725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598004726	active site
557598004727	phosphorylation site [posttranslational modification]
557598004728	intermolecular recognition site; other site
557598004729	dimerization interface [polypeptide binding]; other site
557598004730	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598004731	DNA binding site [nucleotide binding]
557598004732	sensor protein QseC; Provisional; Region: PRK10337
557598004733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598004734	dimer interface [polypeptide binding]; other site
557598004735	phosphorylation site [posttranslational modification]
557598004736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598004737	ATP binding site [chemical binding]; other site
557598004738	Mg2+ binding site [ion binding]; other site
557598004739	G-X-G motif; other site
557598004740	LrgB-like family; Region: LrgB; cl00596
557598004741	LrgA family; Region: LrgA; cl00608
557598004742	hypothetical protein; Provisional; Region: PRK01617
557598004743	SEC-C motif; Region: SEC-C; pfam02810
557598004744	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
557598004745	active site
557598004746	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
557598004747	trimer interface [polypeptide binding]; other site
557598004748	eyelet of channel; other site
557598004749	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
557598004750	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
557598004751	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
557598004752	nudix motif; other site
557598004753	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
557598004754	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598004755	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
557598004756	active site
557598004757	ATP binding site [chemical binding]; other site
557598004758	NlpC/P60 family; Region: NLPC_P60; cl11438
557598004759	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
557598004760	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
557598004761	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
557598004762	Walker A/P-loop; other site
557598004763	ATP binding site [chemical binding]; other site
557598004764	Q-loop/lid; other site
557598004765	ABC transporter signature motif; other site
557598004766	Walker B; other site
557598004767	D-loop; other site
557598004768	H-loop/switch region; other site
557598004769	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
557598004770	Mechanosensitive ion channel; Region: MS_channel; pfam00924
557598004771	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
557598004772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598004773	active site
557598004774	phosphorylation site [posttranslational modification]
557598004775	intermolecular recognition site; other site
557598004776	dimerization interface [polypeptide binding]; other site
557598004777	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598004778	DNA binding residues [nucleotide binding]
557598004779	dimerization interface [polypeptide binding]; other site
557598004780	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
557598004781	nudix motif; other site
557598004782	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
557598004783	active site
557598004784	DNA polymerase IV; Validated; Region: PRK02406
557598004785	DNA binding site [nucleotide binding]
557598004786	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
557598004787	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
557598004788	dimerization interface [polypeptide binding]; other site
557598004789	active site
557598004790	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
557598004791	Ferritin-like domain; Region: Ferritin; pfam00210
557598004792	dimerization interface [polypeptide binding]; other site
557598004793	DPS ferroxidase diiron center [ion binding]; other site
557598004794	ion pore; other site
557598004795	DNA gyrase subunit A; Validated; Region: PRK05560
557598004796	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
557598004797	CAP-like domain; other site
557598004798	active site
557598004799	primary dimer interface [polypeptide binding]; other site
557598004800	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004801	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004802	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004803	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004804	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004805	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
557598004806	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
557598004807	CoenzymeA binding site [chemical binding]; other site
557598004808	subunit interaction site [polypeptide binding]; other site
557598004809	PHB binding site; other site
557598004810	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
557598004811	CoenzymeA binding site [chemical binding]; other site
557598004812	subunit interaction site [polypeptide binding]; other site
557598004813	PHB binding site; other site
557598004814	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
557598004815	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
557598004816	homodimer interface [polypeptide binding]; other site
557598004817	substrate-cofactor binding pocket; other site
557598004818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598004819	catalytic residue [active]
557598004820	Chorismate mutase type II; Region: CM_2; cl00693
557598004821	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
557598004822	Prephenate dehydratase; Region: PDT; pfam00800
557598004823	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
557598004824	putative L-Phe binding site [chemical binding]; other site
557598004825	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
557598004826	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
557598004827	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598004828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598004829	homodimer interface [polypeptide binding]; other site
557598004830	catalytic residue [active]
557598004831	anthranilate synthase component I; Provisional; Region: PRK13565
557598004832	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
557598004833	chorismate binding enzyme; Region: Chorismate_bind; cl10555
557598004834	phosphoglycolate phosphatase; Provisional; Region: PRK13222
557598004835	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598004836	active site
557598004837	motif I; other site
557598004838	motif II; other site
557598004839	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
557598004840	putative active site [active]
557598004841	putative catalytic site [active]
557598004842	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
557598004843	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
557598004844	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
557598004845	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
557598004846	active site
557598004847	HIGH motif; other site
557598004848	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
557598004849	active site
557598004850	KMSKS motif; other site
557598004851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
557598004852	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
557598004853	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
557598004854	TRAM domain; Region: TRAM; cl01282
557598004855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598004856	S-adenosylmethionine binding site [chemical binding]; other site
557598004857	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
557598004858	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
557598004859	NAD binding site [chemical binding]; other site
557598004860	homotetramer interface [polypeptide binding]; other site
557598004861	homodimer interface [polypeptide binding]; other site
557598004862	substrate binding site [chemical binding]; other site
557598004863	active site
557598004864	GAF domain; Region: GAF; cl15785
557598004865	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
557598004866	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
557598004867	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
557598004868	enoyl-CoA hydratase; Provisional; Region: PRK06142
557598004869	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
557598004870	substrate binding site [chemical binding]; other site
557598004871	oxyanion hole (OAH) forming residues; other site
557598004872	trimer interface [polypeptide binding]; other site
557598004873	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
557598004874	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598004875	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598004876	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598004877	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
557598004878	Helix-turn-helix domains; Region: HTH; cl00088
557598004879	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
557598004880	Proline dehydrogenase; Region: Pro_dh; cl03282
557598004881	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
557598004882	Glutamate binding site [chemical binding]; other site
557598004883	NAD binding site [chemical binding]; other site
557598004884	catalytic residues [active]
557598004885	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
557598004886	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
557598004887	dimerization interface [polypeptide binding]; other site
557598004888	ligand binding site [chemical binding]; other site
557598004889	Cupin domain; Region: Cupin_2; cl09118
557598004890	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598004891	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
557598004892	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598004893	Helix-turn-helix domains; Region: HTH; cl00088
557598004894	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
557598004895	substrate binding pocket [chemical binding]; other site
557598004896	dimerization interface [polypeptide binding]; other site
557598004897	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
557598004898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598004899	Transglycosylase; Region: Transgly; cl07896
557598004900	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
557598004901	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
557598004902	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
557598004903	shikimate binding site; other site
557598004904	NAD(P) binding site [chemical binding]; other site
557598004905	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
557598004906	active site residue [active]
557598004907	glutamine synthetase; Provisional; Region: glnA; PRK09469
557598004908	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
557598004909	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
557598004910	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
557598004911	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
557598004912	ring oligomerisation interface [polypeptide binding]; other site
557598004913	ATP/Mg binding site [chemical binding]; other site
557598004914	stacking interactions; other site
557598004915	hinge regions; other site
557598004916	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
557598004917	oligomerisation interface [polypeptide binding]; other site
557598004918	mobile loop; other site
557598004919	roof hairpin; other site
557598004920	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
557598004921	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
557598004922	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
557598004923	Protein of unknown function (DUF465); Region: DUF465; cl01070
557598004924	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
557598004925	glutamate dehydrogenase; Provisional; Region: PRK09414
557598004926	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
557598004927	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
557598004928	NAD(P) binding site [chemical binding]; other site
557598004929	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
557598004930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598004931	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
557598004932	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
557598004933	substrate binding pocket [chemical binding]; other site
557598004934	membrane-bound complex binding site; other site
557598004935	hinge residues; other site
557598004936	Protein of unknown function (DUF2776); Region: DUF2776; pfam10951
557598004937	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
557598004938	lipoprotein; Provisional; Region: PRK10540
557598004939	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
557598004940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598004941	S-adenosylmethionine binding site [chemical binding]; other site
557598004942	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
557598004943	MgtE intracellular N domain; Region: MgtE_N; cl15244
557598004944	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
557598004945	Divalent cation transporter; Region: MgtE; cl00786
557598004946	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
557598004947	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
557598004948	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
557598004949	FAD binding pocket [chemical binding]; other site
557598004950	FAD binding motif [chemical binding]; other site
557598004951	phosphate binding motif [ion binding]; other site
557598004952	beta-alpha-beta structure motif; other site
557598004953	NAD binding pocket [chemical binding]; other site
557598004954	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
557598004955	homotrimer interaction site [polypeptide binding]; other site
557598004956	putative active site [active]
557598004957	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
557598004958	homotrimer interaction site [polypeptide binding]; other site
557598004959	putative active site [active]
557598004960	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
557598004961	homotrimer interaction site [polypeptide binding]; other site
557598004962	putative active site [active]
557598004963	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
557598004964	homotrimer interaction site [polypeptide binding]; other site
557598004965	putative active site [active]
557598004966	hypothetical protein; Provisional; Region: PRK09945
557598004967	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
557598004968	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
557598004969	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598004970	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598004971	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
557598004972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598004973	dimer interface [polypeptide binding]; other site
557598004974	phosphorylation site [posttranslational modification]
557598004975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598004976	ATP binding site [chemical binding]; other site
557598004977	Mg2+ binding site [ion binding]; other site
557598004978	G-X-G motif; other site
557598004979	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
557598004980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598004981	active site
557598004982	phosphorylation site [posttranslational modification]
557598004983	intermolecular recognition site; other site
557598004984	dimerization interface [polypeptide binding]; other site
557598004985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598004986	Walker A motif; other site
557598004987	ATP binding site [chemical binding]; other site
557598004988	Walker B motif; other site
557598004989	arginine finger; other site
557598004990	Helix-turn-helix domains; Region: HTH; cl00088
557598004991	hypothetical protein; Reviewed; Region: PRK00024
557598004992	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
557598004993	MPN+ (JAMM) motif; other site
557598004994	Zinc-binding site [ion binding]; other site
557598004995	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
557598004996	Flavoprotein; Region: Flavoprotein; cl08021
557598004997	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
557598004998	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
557598004999	trimer interface [polypeptide binding]; other site
557598005000	active site
557598005001	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
557598005002	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
557598005003	Walker A/P-loop; other site
557598005004	ATP binding site [chemical binding]; other site
557598005005	Q-loop/lid; other site
557598005006	ABC transporter signature motif; other site
557598005007	Walker B; other site
557598005008	D-loop; other site
557598005009	H-loop/switch region; other site
557598005010	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
557598005011	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
557598005012	Walker A/P-loop; other site
557598005013	ATP binding site [chemical binding]; other site
557598005014	Q-loop/lid; other site
557598005015	ABC transporter signature motif; other site
557598005016	Walker B; other site
557598005017	D-loop; other site
557598005018	H-loop/switch region; other site
557598005019	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
557598005020	TM-ABC transporter signature motif; other site
557598005021	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
557598005022	TM-ABC transporter signature motif; other site
557598005023	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
557598005024	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
557598005025	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
557598005026	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
557598005027	inhibitor-cofactor binding pocket; inhibition site
557598005028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598005029	catalytic residue [active]
557598005030	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
557598005031	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
557598005032	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
557598005033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005034	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
557598005035	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
557598005036	catalytic loop [active]
557598005037	iron binding site [ion binding]; other site
557598005038	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
557598005039	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
557598005040	RNase E interface [polypeptide binding]; other site
557598005041	trimer interface [polypeptide binding]; other site
557598005042	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
557598005043	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
557598005044	RNase E interface [polypeptide binding]; other site
557598005045	trimer interface [polypeptide binding]; other site
557598005046	active site
557598005047	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
557598005048	putative nucleic acid binding region [nucleotide binding]; other site
557598005049	G-X-X-G motif; other site
557598005050	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
557598005051	RNA binding site [nucleotide binding]; other site
557598005052	domain interface; other site
557598005053	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
557598005054	16S/18S rRNA binding site [nucleotide binding]; other site
557598005055	S13e-L30e interaction site [polypeptide binding]; other site
557598005056	25S rRNA binding site [nucleotide binding]; other site
557598005057	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
557598005058	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
557598005059	RNA binding site [nucleotide binding]; other site
557598005060	active site
557598005061	Ribosome-binding factor A; Region: RBFA; cl00542
557598005062	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
557598005063	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
557598005064	translation initiation factor IF-2; Region: IF-2; TIGR00487
557598005065	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
557598005066	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
557598005067	G1 box; other site
557598005068	putative GEF interaction site [polypeptide binding]; other site
557598005069	GTP/Mg2+ binding site [chemical binding]; other site
557598005070	Switch I region; other site
557598005071	G2 box; other site
557598005072	G3 box; other site
557598005073	Switch II region; other site
557598005074	G4 box; other site
557598005075	G5 box; other site
557598005076	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
557598005077	Translation-initiation factor 2; Region: IF-2; pfam11987
557598005078	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
557598005079	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
557598005080	NusA N-terminal domain; Region: NusA_N; pfam08529
557598005081	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
557598005082	RNA binding site [nucleotide binding]; other site
557598005083	homodimer interface [polypeptide binding]; other site
557598005084	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
557598005085	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
557598005086	G-X-X-G motif; other site
557598005087	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
557598005088	ribosome maturation protein RimP; Reviewed; Region: PRK00092
557598005089	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
557598005090	Sm1 motif; other site
557598005091	predicted subunit interaction site [polypeptide binding]; other site
557598005092	RNA binding pocket [nucleotide binding]; other site
557598005093	Sm2 motif; other site
557598005094	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
557598005095	AMP-binding enzyme; Region: AMP-binding; cl15778
557598005096	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598005097	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
557598005098	ArsC family; Region: ArsC; pfam03960
557598005099	putative catalytic residues [active]
557598005100	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
557598005101	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
557598005102	metal binding site [ion binding]; metal-binding site
557598005103	dimer interface [polypeptide binding]; other site
557598005104	MarC family integral membrane protein; Region: MarC; cl00919
557598005105	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
557598005106	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
557598005107	conserved cys residue [active]
557598005108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598005109	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598005110	Cupin domain; Region: Cupin_2; cl09118
557598005111	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
557598005112	nucleophile elbow; other site
557598005113	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
557598005114	Surface antigen; Region: Bac_surface_Ag; cl03097
557598005115	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
557598005116	active site
557598005117	dimerization interface [polypeptide binding]; other site
557598005118	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
557598005119	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598005120	FeS/SAM binding site; other site
557598005121	HemN C-terminal domain; Region: HemN_C; pfam06969
557598005122	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
557598005123	homotrimer interaction site [polypeptide binding]; other site
557598005124	putative active site [active]
557598005125	Mechanosensitive ion channel; Region: MS_channel; pfam00924
557598005126	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
557598005127	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
557598005128	dimer interface [polypeptide binding]; other site
557598005129	active site
557598005130	metal binding site [ion binding]; metal-binding site
557598005131	Protein of unknown function (DUF904); Region: DUF904; cl11531
557598005132	Uncharacterized conserved protein [Function unknown]; Region: COG2308
557598005133	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
557598005134	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
557598005135	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
557598005136	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
557598005137	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
557598005138	active site
557598005139	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
557598005140	putative FMN binding site [chemical binding]; other site
557598005141	Domain of unknown function (DUF296); Region: DUF296; cl00720
557598005142	Cobalt transport protein; Region: CbiQ; cl00463
557598005143	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
557598005144	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
557598005145	Walker A/P-loop; other site
557598005146	ATP binding site [chemical binding]; other site
557598005147	Q-loop/lid; other site
557598005148	ABC transporter signature motif; other site
557598005149	Walker B; other site
557598005150	D-loop; other site
557598005151	H-loop/switch region; other site
557598005152	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
557598005153	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
557598005154	Walker A/P-loop; other site
557598005155	ATP binding site [chemical binding]; other site
557598005156	Q-loop/lid; other site
557598005157	ABC transporter signature motif; other site
557598005158	Walker B; other site
557598005159	D-loop; other site
557598005160	H-loop/switch region; other site
557598005161	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
557598005162	quinone interaction residues [chemical binding]; other site
557598005163	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
557598005164	active site
557598005165	catalytic residues [active]
557598005166	FMN binding site [chemical binding]; other site
557598005167	substrate binding site [chemical binding]; other site
557598005168	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
557598005169	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
557598005170	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
557598005171	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
557598005172	dimerization interface [polypeptide binding]; other site
557598005173	ligand binding site [chemical binding]; other site
557598005174	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
557598005175	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
557598005176	active site
557598005177	metal binding site [ion binding]; metal-binding site
557598005178	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
557598005179	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
557598005180	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598005181	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
557598005182	Walker A/P-loop; other site
557598005183	ATP binding site [chemical binding]; other site
557598005184	Q-loop/lid; other site
557598005185	ABC transporter signature motif; other site
557598005186	Walker B; other site
557598005187	D-loop; other site
557598005188	H-loop/switch region; other site
557598005189	cyanophycin synthetase; Provisional; Region: PRK14016
557598005190	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598005191	cyanophycin synthetase; Provisional; Region: PRK14016
557598005192	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598005193	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598005194	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598005195	PAS fold; Region: PAS_4; pfam08448
557598005196	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598005197	putative active site [active]
557598005198	heme pocket [chemical binding]; other site
557598005199	putative diguanylate cyclase; Provisional; Region: PRK09776
557598005200	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
557598005201	PAS domain; Region: PAS_9; pfam13426
557598005202	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
557598005203	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598005204	metal binding site [ion binding]; metal-binding site
557598005205	active site
557598005206	I-site; other site
557598005207	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
557598005208	Cation efflux family; Region: Cation_efflux; cl00316
557598005209	putative metal dependent hydrolase; Provisional; Region: PRK11598
557598005210	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
557598005211	Sulfatase; Region: Sulfatase; cl10460
557598005212	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
557598005213	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
557598005214	MatE; Region: MatE; cl10513
557598005215	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
557598005216	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
557598005217	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
557598005218	zinc binding site [ion binding]; other site
557598005219	putative ligand binding site [chemical binding]; other site
557598005220	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
557598005221	TM-ABC transporter signature motif; other site
557598005222	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
557598005223	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598005224	Walker A/P-loop; other site
557598005225	ATP binding site [chemical binding]; other site
557598005226	Q-loop/lid; other site
557598005227	ABC transporter signature motif; other site
557598005228	Walker B; other site
557598005229	D-loop; other site
557598005230	H-loop/switch region; other site
557598005231	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598005232	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
557598005233	Baseplate J-like protein; Region: Baseplate_J; cl01294
557598005234	Phage protein GP46; Region: GP46; cl01814
557598005235	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
557598005236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598005237	non-specific DNA binding site [nucleotide binding]; other site
557598005238	Predicted transcriptional regulator [Transcription]; Region: COG2932
557598005239	salt bridge; other site
557598005240	sequence-specific DNA binding site [nucleotide binding]; other site
557598005241	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
557598005242	Catalytic site [active]
557598005243	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
557598005244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598005245	S-adenosylmethionine binding site [chemical binding]; other site
557598005246	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598005247	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598005248	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
557598005249	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
557598005250	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598005251	hypothetical protein; Provisional; Region: PHA02515
557598005252	hypothetical protein; Provisional; Region: PHA02515
557598005253	Mor transcription activator family; Region: Mor; cl02360
557598005254	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
557598005255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005256	potential frameshift: common BLAST hit: gi|94310245|ref|YP_583455.1| integrase catalytic subunit
557598005257	Integrase core domain; Region: rve_3; cl15866
557598005258	Integrase core domain; Region: rve; cl01316
557598005259	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598005260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
557598005261	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
557598005262	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
557598005263	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
557598005264	putative cation:proton antiport protein; Provisional; Region: PRK10669
557598005265	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
557598005266	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
557598005267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005268	Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794
557598005269	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
557598005270	putative active site [active]
557598005271	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
557598005272	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
557598005273	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598005274	active site
557598005275	motif I; other site
557598005276	motif II; other site
557598005277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
557598005278	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
557598005279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
557598005280	OstA-like protein; Region: OstA; cl00844
557598005281	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
557598005282	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
557598005283	Walker A/P-loop; other site
557598005284	ATP binding site [chemical binding]; other site
557598005285	Q-loop/lid; other site
557598005286	ABC transporter signature motif; other site
557598005287	Walker B; other site
557598005288	D-loop; other site
557598005289	H-loop/switch region; other site
557598005290	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
557598005291	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
557598005292	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
557598005293	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
557598005294	30S subunit binding site; other site
557598005295	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
557598005296	active site
557598005297	phosphorylation site [posttranslational modification]
557598005298	HPr kinase/phosphorylase; Provisional; Region: PRK05428
557598005299	DRTGG domain; Region: DRTGG; cl12147
557598005300	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
557598005301	Hpr binding site; other site
557598005302	active site
557598005303	homohexamer subunit interaction site [polypeptide binding]; other site
557598005304	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
557598005305	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
557598005306	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
557598005307	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
557598005308	aromatic acid decarboxylase; Validated; Region: PRK05920
557598005309	Flavoprotein; Region: Flavoprotein; cl08021
557598005310	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
557598005311	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
557598005312	putative ATP binding site [chemical binding]; other site
557598005313	putative substrate binding site [chemical binding]; other site
557598005314	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
557598005315	RNA binding surface [nucleotide binding]; other site
557598005316	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
557598005317	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598005318	dimer interface [polypeptide binding]; other site
557598005319	putative CheW interface [polypeptide binding]; other site
557598005320	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
557598005321	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
557598005322	DNA repair protein RadA; Provisional; Region: PRK11823
557598005323	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
557598005324	Walker A motif/ATP binding site; other site
557598005325	ATP binding site [chemical binding]; other site
557598005326	Walker B motif; other site
557598005327	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
557598005328	short chain dehydrogenase; Provisional; Region: PRK08703
557598005329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005330	NAD(P) binding site [chemical binding]; other site
557598005331	active site
557598005332	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
557598005333	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
557598005334	catalytic residues [active]
557598005335	substrate binding pocket [chemical binding]; other site
557598005336	substrate-Mg2+ binding site; other site
557598005337	aspartate-rich region 1; other site
557598005338	aspartate-rich region 2; other site
557598005339	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
557598005340	active site lid residues [active]
557598005341	substrate binding pocket [chemical binding]; other site
557598005342	catalytic residues [active]
557598005343	substrate-Mg2+ binding site; other site
557598005344	aspartate-rich region 1; other site
557598005345	aspartate-rich region 2; other site
557598005346	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
557598005347	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
557598005348	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
557598005349	Walker A/P-loop; other site
557598005350	ATP binding site [chemical binding]; other site
557598005351	Q-loop/lid; other site
557598005352	ABC transporter signature motif; other site
557598005353	Walker B; other site
557598005354	D-loop; other site
557598005355	H-loop/switch region; other site
557598005356	NIL domain; Region: NIL; cl09633
557598005357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598005358	dimer interface [polypeptide binding]; other site
557598005359	conserved gate region; other site
557598005360	ABC-ATPase subunit interface; other site
557598005361	NMT1-like family; Region: NMT1_2; cl15260
557598005362	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
557598005363	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
557598005364	Walker A/P-loop; other site
557598005365	ATP binding site [chemical binding]; other site
557598005366	Q-loop/lid; other site
557598005367	ABC transporter signature motif; other site
557598005368	Walker B; other site
557598005369	D-loop; other site
557598005370	H-loop/switch region; other site
557598005371	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
557598005372	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
557598005373	FtsX-like permease family; Region: FtsX; cl15850
557598005374	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598005375	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598005376	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598005377	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
557598005378	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
557598005379	active site
557598005380	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
557598005381	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
557598005382	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
557598005383	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
557598005384	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
557598005385	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
557598005386	carboxyltransferase (CT) interaction site; other site
557598005387	biotinylation site [posttranslational modification]; other site
557598005388	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
557598005389	active site
557598005390	catalytic residues [active]
557598005391	metal binding site [ion binding]; metal-binding site
557598005392	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
557598005393	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
557598005394	AMP-binding enzyme; Region: AMP-binding; cl15778
557598005395	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598005396	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
557598005397	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
557598005398	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
557598005399	active site
557598005400	catalytic residues [active]
557598005401	metal binding site [ion binding]; metal-binding site
557598005402	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
557598005403	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
557598005404	AMP-binding enzyme; Region: AMP-binding; cl15778
557598005405	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598005406	Flagellin N-methylase; Region: FliB; cl00497
557598005407	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
557598005408	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
557598005409	FMN binding site [chemical binding]; other site
557598005410	active site
557598005411	catalytic residues [active]
557598005412	substrate binding site [chemical binding]; other site
557598005413	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
557598005414	Zn2+ binding site [ion binding]; other site
557598005415	Mg2+ binding site [ion binding]; other site
557598005416	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
557598005417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598005418	non-specific DNA binding site [nucleotide binding]; other site
557598005419	salt bridge; other site
557598005420	sequence-specific DNA binding site [nucleotide binding]; other site
557598005421	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
557598005422	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
557598005423	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
557598005424	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
557598005425	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
557598005426	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
557598005427	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
557598005428	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
557598005429	catalytic residue [active]
557598005430	putative FPP diphosphate  binding site; other site
557598005431	putative FPP binding hydrophobic cleft; other site
557598005432	dimer interface [polypeptide binding]; other site
557598005433	putative IPP diphosphate binding site; other site
557598005434	ribosome recycling factor; Reviewed; Region: frr; PRK00083
557598005435	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
557598005436	hinge region; other site
557598005437	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
557598005438	putative nucleotide binding site [chemical binding]; other site
557598005439	uridine monophosphate binding site [chemical binding]; other site
557598005440	homohexameric interface [polypeptide binding]; other site
557598005441	elongation factor Ts; Provisional; Region: tsf; PRK09377
557598005442	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
557598005443	Elongation factor TS; Region: EF_TS; pfam00889
557598005444	Elongation factor TS; Region: EF_TS; pfam00889
557598005445	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
557598005446	rRNA interaction site [nucleotide binding]; other site
557598005447	S8 interaction site; other site
557598005448	putative laminin-1 binding site; other site
557598005449	transcriptional regulator NarL; Provisional; Region: PRK10651
557598005450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598005451	active site
557598005452	phosphorylation site [posttranslational modification]
557598005453	intermolecular recognition site; other site
557598005454	dimerization interface [polypeptide binding]; other site
557598005455	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598005456	DNA binding residues [nucleotide binding]
557598005457	dimerization interface [polypeptide binding]; other site
557598005458	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
557598005459	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
557598005460	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598005461	dimerization interface [polypeptide binding]; other site
557598005462	GAF domain; Region: GAF; cl15785
557598005463	Histidine kinase; Region: HisKA_3; pfam07730
557598005464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598005465	ATP binding site [chemical binding]; other site
557598005466	Mg2+ binding site [ion binding]; other site
557598005467	G-X-G motif; other site
557598005468	ferredoxin-type protein; Provisional; Region: PRK10194
557598005469	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
557598005470	NapD protein; Region: NapD; cl01163
557598005471	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
557598005472	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
557598005473	[4Fe-4S] binding site [ion binding]; other site
557598005474	molybdopterin cofactor binding site; other site
557598005475	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
557598005476	molybdopterin cofactor binding site; other site
557598005477	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
557598005478	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
557598005479	4Fe-4S binding domain; Region: Fer4_5; pfam12801
557598005480	4Fe-4S binding domain; Region: Fer4_5; pfam12801
557598005481	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
557598005482	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
557598005483	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
557598005484	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
557598005485	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598005486	Walker A/P-loop; other site
557598005487	ATP binding site [chemical binding]; other site
557598005488	Q-loop/lid; other site
557598005489	ABC transporter signature motif; other site
557598005490	Walker B; other site
557598005491	D-loop; other site
557598005492	H-loop/switch region; other site
557598005493	CcmB protein; Region: CcmB; cl01016
557598005494	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
557598005495	Heme exporter protein D (CcmD); Region: CcmD; cl11475
557598005496	CcmE; Region: CcmE; cl00994
557598005497	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
557598005498	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
557598005499	catalytic residues [active]
557598005500	central insert; other site
557598005501	Cytochrome C biogenesis protein; Region: CcmH; cl01179
557598005502	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
557598005503	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
557598005504	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
557598005505	4Fe-4S binding domain; Region: Fer4; cl02805
557598005506	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
557598005507	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
557598005508	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598005509	DNA-binding site [nucleotide binding]; DNA binding site
557598005510	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598005511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598005512	homodimer interface [polypeptide binding]; other site
557598005513	catalytic residue [active]
557598005514	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
557598005515	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
557598005516	dimerization interface [polypeptide binding]; other site
557598005517	ligand binding site [chemical binding]; other site
557598005518	ScpA/B protein; Region: ScpA_ScpB; cl00598
557598005519	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
557598005520	active site
557598005521	HIGH motif; other site
557598005522	dimer interface [polypeptide binding]; other site
557598005523	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598005524	active site
557598005525	KMSKS motif; other site
557598005526	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
557598005527	active site
557598005528	putative substrate binding region [chemical binding]; other site
557598005529	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
557598005530	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
557598005531	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
557598005532	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
557598005533	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
557598005534	active site
557598005535	homodimer interface [polypeptide binding]; other site
557598005536	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
557598005537	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
557598005538	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
557598005539	homodimer interface [polypeptide binding]; other site
557598005540	substrate-cofactor binding pocket; other site
557598005541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598005542	catalytic residue [active]
557598005543	amidophosphoribosyltransferase; Provisional; Region: PRK09246
557598005544	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
557598005545	active site
557598005546	tetramer interface [polypeptide binding]; other site
557598005547	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598005548	active site
557598005549	Colicin V production protein; Region: Colicin_V; cl00567
557598005550	Sporulation related domain; Region: SPOR; cl10051
557598005551	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
557598005552	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598005553	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598005554	ABC transporter ATPase component; Reviewed; Region: PRK11147
557598005555	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598005556	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598005557	ABC transporter; Region: ABC_tran_2; pfam12848
557598005558	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
557598005559	NlpC/P60 family; Region: NLPC_P60; cl11438
557598005560	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
557598005561	AMP binding site [chemical binding]; other site
557598005562	metal binding site [ion binding]; metal-binding site
557598005563	active site
557598005564	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
557598005565	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598005566	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
557598005567	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
557598005568	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
557598005569	Int/Topo IB signature motif; other site
557598005570	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
557598005571	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
557598005572	[2Fe-2S] cluster binding site [ion binding]; other site
557598005573	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
557598005574	alpha subunit interface [polypeptide binding]; other site
557598005575	active site
557598005576	substrate binding site [chemical binding]; other site
557598005577	Fe binding site [ion binding]; other site
557598005578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598005579	putative substrate translocation pore; other site
557598005580	Protein of unknown function (DUF342); Region: DUF342; pfam03961
557598005581	Protein of unknown function (DUF342); Region: DUF342; pfam03961
557598005582	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
557598005583	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
557598005584	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598005585	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598005586	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
557598005587	Protein export membrane protein; Region: SecD_SecF; cl14618
557598005588	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
557598005589	transcriptional regulator BetI; Validated; Region: PRK00767
557598005590	Helix-turn-helix domains; Region: HTH; cl00088
557598005591	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
557598005592	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
557598005593	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
557598005594	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598005595	DEAD_2; Region: DEAD_2; pfam06733
557598005596	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598005597	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
557598005598	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
557598005599	ligand binding site [chemical binding]; other site
557598005600	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005601	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
557598005602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005603	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
557598005604	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
557598005605	proline aminopeptidase P II; Provisional; Region: PRK10879
557598005606	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
557598005607	active site
557598005608	VanZ like family; Region: VanZ; cl01971
557598005609	acyl-CoA synthetase; Validated; Region: PRK08162
557598005610	AMP-binding enzyme; Region: AMP-binding; cl15778
557598005611	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
557598005612	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
557598005613	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
557598005614	Predicted amidohydrolase [General function prediction only]; Region: COG0388
557598005615	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
557598005616	putative active site [active]
557598005617	catalytic triad [active]
557598005618	dimer interface [polypeptide binding]; other site
557598005619	TIGR02099 family protein; Region: TIGR02099
557598005620	AsmA-like C-terminal region; Region: AsmA_2; cl15864
557598005621	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
557598005622	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
557598005623	metal binding triad; other site
557598005624	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
557598005625	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
557598005626	metal binding triad; other site
557598005627	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
557598005628	homodimer interface [polypeptide binding]; other site
557598005629	substrate-cofactor binding pocket; other site
557598005630	catalytic residue [active]
557598005631	Zinc-finger domain; Region: zf-CHCC; cl01821
557598005632	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
557598005633	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
557598005634	putative active site [active]
557598005635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
557598005636	Helix-turn-helix domains; Region: HTH; cl00088
557598005637	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
557598005638	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
557598005639	G1 box; other site
557598005640	putative GEF interaction site [polypeptide binding]; other site
557598005641	GTP/Mg2+ binding site [chemical binding]; other site
557598005642	Switch I region; other site
557598005643	G2 box; other site
557598005644	G3 box; other site
557598005645	Switch II region; other site
557598005646	G4 box; other site
557598005647	G5 box; other site
557598005648	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
557598005649	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
557598005650	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
557598005651	active site
557598005652	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
557598005653	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
557598005654	substrate binding site [chemical binding]; other site
557598005655	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
557598005656	substrate binding site [chemical binding]; other site
557598005657	ligand binding site [chemical binding]; other site
557598005658	aconitate hydratase; Validated; Region: PRK09277
557598005659	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
557598005660	substrate binding site [chemical binding]; other site
557598005661	ligand binding site [chemical binding]; other site
557598005662	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
557598005663	substrate binding site [chemical binding]; other site
557598005664	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
557598005665	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
557598005666	tetramer interface [polypeptide binding]; other site
557598005667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598005668	catalytic residue [active]
557598005669	EamA-like transporter family; Region: EamA; cl01037
557598005670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598005671	PAS fold; Region: PAS_3; pfam08447
557598005672	putative active site [active]
557598005673	heme pocket [chemical binding]; other site
557598005674	Uncharacterized conserved protein [Function unknown]; Region: COG1315
557598005675	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
557598005676	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598005677	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
557598005678	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598005679	Cyclophilin-like; Region: Cyclophil_like; cl00950
557598005680	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
557598005681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598005682	putative substrate translocation pore; other site
557598005683	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598005684	Helix-turn-helix domains; Region: HTH; cl00088
557598005685	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
557598005686	putative effector binding pocket; other site
557598005687	putative dimerization interface [polypeptide binding]; other site
557598005688	Cache domain; Region: Cache_1; pfam02743
557598005689	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
557598005690	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598005691	dimerization interface [polypeptide binding]; other site
557598005692	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598005693	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598005694	dimer interface [polypeptide binding]; other site
557598005695	putative CheW interface [polypeptide binding]; other site
557598005696	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
557598005697	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
557598005698	NAD(P) binding site [chemical binding]; other site
557598005699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005700	FAD dependent oxidoreductase; Region: DAO; pfam01266
557598005701	N-carbamolyputrescine amidase; Region: PLN02747
557598005702	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
557598005703	putative active site; other site
557598005704	catalytic triad [active]
557598005705	putative dimer interface [polypeptide binding]; other site
557598005706	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
557598005707	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
557598005708	ANP binding site [chemical binding]; other site
557598005709	Substrate Binding Site II [chemical binding]; other site
557598005710	Substrate Binding Site I [chemical binding]; other site
557598005711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598005712	putative substrate translocation pore; other site
557598005713	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
557598005714	Helix-turn-helix domains; Region: HTH; cl00088
557598005715	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
557598005716	dimerization interface [polypeptide binding]; other site
557598005717	substrate binding pocket [chemical binding]; other site
557598005718	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
557598005719	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
557598005720	IHF dimer interface [polypeptide binding]; other site
557598005721	IHF - DNA interface [nucleotide binding]; other site
557598005722	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
557598005723	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
557598005724	putative active site [active]
557598005725	putative dimer interface [polypeptide binding]; other site
557598005726	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
557598005727	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
557598005728	putative C-terminal domain interface [polypeptide binding]; other site
557598005729	putative GSH binding site (G-site) [chemical binding]; other site
557598005730	putative dimer interface [polypeptide binding]; other site
557598005731	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
557598005732	putative substrate binding pocket (H-site) [chemical binding]; other site
557598005733	putative N-terminal domain interface [polypeptide binding]; other site
557598005734	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
557598005735	active site
557598005736	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
557598005737	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
557598005738	dimerization interface [polypeptide binding]; other site
557598005739	domain crossover interface; other site
557598005740	redox-dependent activation switch; other site
557598005741	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
557598005742	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005743	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
557598005744	L-serine binding site [chemical binding]; other site
557598005745	ACT domain interface; other site
557598005746	Predicted membrane protein [Function unknown]; Region: COG2119
557598005747	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
557598005748	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
557598005749	Acylphosphatase; Region: Acylphosphatase; cl00551
557598005750	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
557598005751	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
557598005752	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
557598005753	NlpE N-terminal domain; Region: NlpE; cl01138
557598005754	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
557598005755	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
557598005756	RNA binding surface [nucleotide binding]; other site
557598005757	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
557598005758	probable active site [active]
557598005759	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
557598005760	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
557598005761	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
557598005762	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
557598005763	active site
557598005764	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
557598005765	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
557598005766	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
557598005767	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
557598005768	Walker A/P-loop; other site
557598005769	ATP binding site [chemical binding]; other site
557598005770	Q-loop/lid; other site
557598005771	ABC transporter signature motif; other site
557598005772	Walker B; other site
557598005773	D-loop; other site
557598005774	H-loop/switch region; other site
557598005775	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
557598005776	active site
557598005777	catalytic triad [active]
557598005778	oxyanion hole [active]
557598005779	switch loop; other site
557598005780	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
557598005781	two component system sensor kinase SsrA; Provisional; Region: PRK15347
557598005782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
557598005783	dimer interface [polypeptide binding]; other site
557598005784	phosphorylation site [posttranslational modification]
557598005785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
557598005786	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
557598005787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598005788	active site
557598005789	phosphorylation site [posttranslational modification]
557598005790	intermolecular recognition site; other site
557598005791	dimerization interface [polypeptide binding]; other site
557598005792	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
557598005793	DNA binding site [nucleotide binding]
557598005794	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
557598005795	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
557598005796	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
557598005797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005798	flagellar motor protein MotB; Validated; Region: motB; PRK09041
557598005799	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
557598005800	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
557598005801	ligand binding site [chemical binding]; other site
557598005802	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
557598005803	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
557598005804	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
557598005805	putative aminotransferase; Validated; Region: PRK07480
557598005806	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
557598005807	inhibitor-cofactor binding pocket; inhibition site
557598005808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598005809	catalytic residue [active]
557598005810	Peptidase C26; Region: Peptidase_C26; pfam07722
557598005811	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
557598005812	catalytic triad [active]
557598005813	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
557598005814	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
557598005815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598005816	Cupin domain; Region: Cupin_2; cl09118
557598005817	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
557598005818	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
557598005819	NAD(P) binding site [chemical binding]; other site
557598005820	catalytic residues [active]
557598005821	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
557598005822	active site residue [active]
557598005823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
557598005824	dimerization interface [polypeptide binding]; other site
557598005825	putative DNA binding site [nucleotide binding]; other site
557598005826	putative Zn2+ binding site [ion binding]; other site
557598005827	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
557598005828	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
557598005829	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
557598005830	putative active site [active]
557598005831	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
557598005832	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
557598005833	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
557598005834	RNA binding surface [nucleotide binding]; other site
557598005835	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
557598005836	active site
557598005837	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
557598005838	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
557598005839	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
557598005840	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
557598005841	DNA-binding site [nucleotide binding]; DNA binding site
557598005842	RNA-binding motif; other site
557598005843	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
557598005844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598005845	dimer interface [polypeptide binding]; other site
557598005846	conserved gate region; other site
557598005847	putative PBP binding loops; other site
557598005848	ABC-ATPase subunit interface; other site
557598005849	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
557598005850	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
557598005851	substrate binding pocket [chemical binding]; other site
557598005852	membrane-bound complex binding site; other site
557598005853	hinge residues; other site
557598005854	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
557598005855	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
557598005856	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
557598005857	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
557598005858	RNA binding site [nucleotide binding]; other site
557598005859	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
557598005860	EamA-like transporter family; Region: EamA; cl01037
557598005861	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
557598005862	TMAO/DMSO reductase; Reviewed; Region: PRK05363
557598005863	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
557598005864	Moco binding site; other site
557598005865	metal coordination site [ion binding]; other site
557598005866	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598005867	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
557598005868	peptidase T; Region: peptidase-T; TIGR01882
557598005869	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
557598005870	metal binding site [ion binding]; metal-binding site
557598005871	dimer interface [polypeptide binding]; other site
557598005872	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
557598005873	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
557598005874	ABC-2 type transporter; Region: ABC2_membrane; cl11417
557598005875	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
557598005876	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
557598005877	Walker A/P-loop; other site
557598005878	ATP binding site [chemical binding]; other site
557598005879	Q-loop/lid; other site
557598005880	ABC transporter signature motif; other site
557598005881	Walker B; other site
557598005882	D-loop; other site
557598005883	H-loop/switch region; other site
557598005884	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598005885	Walker A/P-loop; other site
557598005886	ATP binding site [chemical binding]; other site
557598005887	Q-loop/lid; other site
557598005888	ABC transporter signature motif; other site
557598005889	Walker B; other site
557598005890	D-loop; other site
557598005891	H-loop/switch region; other site
557598005892	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
557598005893	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
557598005894	ABC-2 type transporter; Region: ABC2_membrane; cl11417
557598005895	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598005896	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598005897	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598005898	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598005899	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
557598005900	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598005901	Dehydratase family; Region: ILVD_EDD; cl00340
557598005902	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
557598005903	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
557598005904	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
557598005905	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
557598005906	putative active site [active]
557598005907	putative metal binding residues [ion binding]; other site
557598005908	signature motif; other site
557598005909	putative dimer interface [polypeptide binding]; other site
557598005910	putative phosphate binding site [ion binding]; other site
557598005911	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
557598005912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598005913	Walker A motif; other site
557598005914	ATP binding site [chemical binding]; other site
557598005915	Walker B motif; other site
557598005916	arginine finger; other site
557598005917	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
557598005918	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
557598005919	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
557598005920	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
557598005921	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
557598005922	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
557598005923	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
557598005924	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
557598005925	ATP cone domain; Region: ATP-cone; pfam03477
557598005926	Class III ribonucleotide reductase; Region: RNR_III; cd01675
557598005927	effector binding site; other site
557598005928	active site
557598005929	Zn binding site [ion binding]; other site
557598005930	glycine loop; other site
557598005931	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
557598005932	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
557598005933	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
557598005934	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
557598005935	dimer interface [polypeptide binding]; other site
557598005936	ADP-ribose binding site [chemical binding]; other site
557598005937	active site
557598005938	nudix motif; other site
557598005939	metal binding site [ion binding]; metal-binding site
557598005940	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
557598005941	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
557598005942	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
557598005943	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
557598005944	active site
557598005945	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
557598005946	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
557598005947	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
557598005948	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
557598005949	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
557598005950	putative active site [active]
557598005951	dimerization interface [polypeptide binding]; other site
557598005952	putative tRNAtyr binding site [nucleotide binding]; other site
557598005953	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
557598005954	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
557598005955	homotrimer interaction site [polypeptide binding]; other site
557598005956	putative active site [active]
557598005957	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
557598005958	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
557598005959	E3 interaction surface; other site
557598005960	lipoyl attachment site [posttranslational modification]; other site
557598005961	e3 binding domain; Region: E3_binding; pfam02817
557598005962	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
557598005963	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
557598005964	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
557598005965	alpha subunit interface [polypeptide binding]; other site
557598005966	TPP binding site [chemical binding]; other site
557598005967	heterodimer interface [polypeptide binding]; other site
557598005968	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
557598005969	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
557598005970	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
557598005971	tetramer interface [polypeptide binding]; other site
557598005972	TPP-binding site [chemical binding]; other site
557598005973	heterodimer interface [polypeptide binding]; other site
557598005974	phosphorylation loop region [posttranslational modification]
557598005975	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
557598005976	active site
557598005977	catalytic site [active]
557598005978	substrate binding site [chemical binding]; other site
557598005979	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
557598005980	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598005981	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598005982	CHASE domain; Region: CHASE; cl01369
557598005983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598005984	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
557598005985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
557598005986	dimer interface [polypeptide binding]; other site
557598005987	phosphorylation site [posttranslational modification]
557598005988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598005989	ATP binding site [chemical binding]; other site
557598005990	Mg2+ binding site [ion binding]; other site
557598005991	G-X-G motif; other site
557598005992	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
557598005993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598005994	active site
557598005995	phosphorylation site [posttranslational modification]
557598005996	intermolecular recognition site; other site
557598005997	dimerization interface [polypeptide binding]; other site
557598005998	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598005999	DNA binding residues [nucleotide binding]
557598006000	dimerization interface [polypeptide binding]; other site
557598006001	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
557598006002	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598006003	ATP binding site [chemical binding]; other site
557598006004	putative Mg++ binding site [ion binding]; other site
557598006005	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598006006	Helicase associated domain (HA2); Region: HA2; cl04503
557598006007	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
557598006008	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
557598006009	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
557598006010	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
557598006011	Potassium binding sites [ion binding]; other site
557598006012	Cesium cation binding sites [ion binding]; other site
557598006013	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
557598006014	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
557598006015	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
557598006016	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
557598006017	active site
557598006018	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
557598006019	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
557598006020	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
557598006021	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
557598006022	trimer interface [polypeptide binding]; other site
557598006023	active site
557598006024	UDP-GlcNAc binding site [chemical binding]; other site
557598006025	lipid binding site [chemical binding]; lipid-binding site
557598006026	periplasmic chaperone; Provisional; Region: PRK10780
557598006027	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
557598006028	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
557598006029	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
557598006030	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
557598006031	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
557598006032	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
557598006033	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
557598006034	Surface antigen; Region: Bac_surface_Ag; cl03097
557598006035	zinc metallopeptidase RseP; Provisional; Region: PRK10779
557598006036	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
557598006037	active site
557598006038	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
557598006039	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
557598006040	protein binding site [polypeptide binding]; other site
557598006041	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
557598006042	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
557598006043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598006044	Helix-turn-helix domains; Region: HTH; cl00088
557598006045	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
557598006046	putative dimerization interface [polypeptide binding]; other site
557598006047	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
557598006048	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
557598006049	active site 1 [active]
557598006050	dimer interface [polypeptide binding]; other site
557598006051	hexamer interface [polypeptide binding]; other site
557598006052	active site 2 [active]
557598006053	Nucleoside recognition; Region: Gate; cl00486
557598006054	Nucleoside recognition; Region: Gate; cl00486
557598006055	Nucleoside recognition; Region: Gate; cl00486
557598006056	Chorismate mutase type II; Region: CM_2; cl00693
557598006057	MarC family integral membrane protein; Region: MarC; cl00919
557598006058	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
557598006059	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
557598006060	active site
557598006061	NTP binding site [chemical binding]; other site
557598006062	metal binding triad [ion binding]; metal-binding site
557598006063	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
557598006064	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
557598006065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
557598006066	MOSC domain; Region: MOSC; pfam03473
557598006067	Protein of unknown function (DUF328); Region: DUF328; cl01143
557598006068	putative cation:proton antiport protein; Provisional; Region: PRK10669
557598006069	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
557598006070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006071	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
557598006072	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
557598006073	dimer interface [polypeptide binding]; other site
557598006074	putative functional site; other site
557598006075	putative MPT binding site; other site
557598006076	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
557598006077	Walker A motif; other site
557598006078	aminotransferase; Validated; Region: PRK07337
557598006079	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598006080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598006081	homodimer interface [polypeptide binding]; other site
557598006082	catalytic residue [active]
557598006083	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
557598006084	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
557598006085	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
557598006086	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
557598006087	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
557598006088	NAD(P) binding site [chemical binding]; other site
557598006089	catalytic residues [active]
557598006090	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
557598006091	YfaZ precursor; Region: YfaZ; pfam07437
557598006092	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
557598006093	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
557598006094	tetramer interface [polypeptide binding]; other site
557598006095	active site
557598006096	Mg2+/Mn2+ binding site [ion binding]; other site
557598006097	Cupin domain; Region: Cupin_2; cl09118
557598006098	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
557598006099	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
557598006100	dimer interface [polypeptide binding]; other site
557598006101	active site
557598006102	citrylCoA binding site [chemical binding]; other site
557598006103	oxalacetate/citrate binding site [chemical binding]; other site
557598006104	coenzyme A binding site [chemical binding]; other site
557598006105	catalytic triad [active]
557598006106	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
557598006107	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
557598006108	substrate binding site [chemical binding]; other site
557598006109	ligand binding site [chemical binding]; other site
557598006110	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
557598006111	substrate binding site [chemical binding]; other site
557598006112	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
557598006113	PrpF protein; Region: PrpF; pfam04303
557598006114	Integrase core domain; Region: rve; cl01316
557598006115	Integrase core domain; Region: rve_3; cl15866
557598006116	Competence-damaged protein; Region: CinA; cl00666
557598006117	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
557598006118	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
557598006119	active site
557598006120	dimer interface [polypeptide binding]; other site
557598006121	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
557598006122	dimer interface [polypeptide binding]; other site
557598006123	active site
557598006124	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
557598006125	active site
557598006126	substrate binding site [chemical binding]; other site
557598006127	catalytic site [active]
557598006128	short chain dehydrogenase; Validated; Region: PRK06182
557598006129	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
557598006130	NADP binding site [chemical binding]; other site
557598006131	active site
557598006132	steroid binding site; other site
557598006133	Integral membrane protein TerC family; Region: TerC; cl10468
557598006134	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598006135	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
557598006136	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
557598006137	substrate binding pocket [chemical binding]; other site
557598006138	chain length determination region; other site
557598006139	substrate-Mg2+ binding site; other site
557598006140	catalytic residues [active]
557598006141	aspartate-rich region 1; other site
557598006142	active site lid residues [active]
557598006143	aspartate-rich region 2; other site
557598006144	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
557598006145	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
557598006146	TPP-binding site; other site
557598006147	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
557598006148	PYR/PP interface [polypeptide binding]; other site
557598006149	dimer interface [polypeptide binding]; other site
557598006150	TPP binding site [chemical binding]; other site
557598006151	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
557598006152	Predicted membrane protein [Function unknown]; Region: COG3174
557598006153	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
557598006154	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
557598006155	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
557598006156	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598006157	FeS/SAM binding site; other site
557598006158	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
557598006159	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
557598006160	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
557598006161	G1 box; other site
557598006162	GTP/Mg2+ binding site [chemical binding]; other site
557598006163	Switch I region; other site
557598006164	G2 box; other site
557598006165	Switch II region; other site
557598006166	G3 box; other site
557598006167	G4 box; other site
557598006168	G5 box; other site
557598006169	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
557598006170	catalytic loop [active]
557598006171	iron binding site [ion binding]; other site
557598006172	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
557598006173	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
557598006174	4Fe-4S binding domain; Region: Fer4; cl02805
557598006175	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
557598006176	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
557598006177	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
557598006178	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
557598006179	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
557598006180	biotin synthase; Provisional; Region: PRK07094
557598006181	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
557598006182	FeS/SAM binding site; other site
557598006183	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
557598006184	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
557598006185	dimer interface [polypeptide binding]; other site
557598006186	putative inhibitory loop; other site
557598006187	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
557598006188	hypothetical protein; Provisional; Region: PRK01254
557598006189	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
557598006190	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
557598006191	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
557598006192	feedback inhibition sensing region; other site
557598006193	homohexameric interface [polypeptide binding]; other site
557598006194	nucleotide binding site [chemical binding]; other site
557598006195	N-acetyl-L-glutamate binding site [chemical binding]; other site
557598006196	N-acetylglutamate synthase; Validated; Region: PRK05279
557598006197	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
557598006198	putative feedback inhibition sensing region; other site
557598006199	putative nucleotide binding site [chemical binding]; other site
557598006200	putative substrate binding site [chemical binding]; other site
557598006201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
557598006202	Coenzyme A binding pocket [chemical binding]; other site
557598006203	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
557598006204	Iron-sulfur protein interface; other site
557598006205	proximal heme binding site [chemical binding]; other site
557598006206	distal heme binding site [chemical binding]; other site
557598006207	dimer interface [polypeptide binding]; other site
557598006208	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
557598006209	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006210	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
557598006211	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
557598006212	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
557598006213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006214	SurA N-terminal domain; Region: SurA_N_3; cl07813
557598006215	periplasmic folding chaperone; Provisional; Region: PRK10788
557598006216	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598006217	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
557598006218	IHF dimer interface [polypeptide binding]; other site
557598006219	IHF - DNA interface [nucleotide binding]; other site
557598006220	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
557598006221	Found in ATP-dependent protease La (LON); Region: LON; smart00464
557598006222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598006223	Walker A motif; other site
557598006224	ATP binding site [chemical binding]; other site
557598006225	Walker B motif; other site
557598006226	arginine finger; other site
557598006227	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
557598006228	Transcriptional regulator; Region: Transcrip_reg; cl00361
557598006229	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
557598006230	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
557598006231	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598006232	FliP family; Region: FliP; cl00593
557598006233	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
557598006234	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
557598006235	flagellar motor switch protein; Validated; Region: fliN; PRK05698
557598006236	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
557598006237	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
557598006238	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
557598006239	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
557598006240	flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161
557598006241	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
557598006242	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
557598006243	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
557598006244	Walker A motif/ATP binding site; other site
557598006245	Walker B motif; other site
557598006246	Flagellar assembly protein FliH; Region: FliH; pfam02108
557598006247	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
557598006248	MgtE intracellular N domain; Region: MgtE_N; cl15244
557598006249	FliG C-terminal domain; Region: FliG_C; pfam01706
557598006250	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
557598006251	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
557598006252	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
557598006253	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
557598006254	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
557598006255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598006256	active site
557598006257	phosphorylation site [posttranslational modification]
557598006258	intermolecular recognition site; other site
557598006259	dimerization interface [polypeptide binding]; other site
557598006260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598006261	Walker A motif; other site
557598006262	ATP binding site [chemical binding]; other site
557598006263	Walker B motif; other site
557598006264	arginine finger; other site
557598006265	Helix-turn-helix domains; Region: HTH; cl00088
557598006266	CheB methylesterase; Region: CheB_methylest; pfam01339
557598006267	PAS fold; Region: PAS_3; pfam08447
557598006268	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598006269	PAS domain; Region: PAS_9; pfam13426
557598006270	putative active site [active]
557598006271	heme pocket [chemical binding]; other site
557598006272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598006273	PAS domain; Region: PAS_9; pfam13426
557598006274	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598006275	metal binding site [ion binding]; metal-binding site
557598006276	active site
557598006277	I-site; other site
557598006278	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598006279	Low molecular weight phosphatase family; Region: LMWPc; cd00115
557598006280	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
557598006281	active site
557598006282	OsmC-like protein; Region: OsmC; cl00767
557598006283	UGMP family protein; Validated; Region: PRK09604
557598006284	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
557598006285	recombination factor protein RarA; Reviewed; Region: PRK13342
557598006286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598006287	Walker A motif; other site
557598006288	ATP binding site [chemical binding]; other site
557598006289	Walker B motif; other site
557598006290	arginine finger; other site
557598006291	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
557598006292	OpgC protein; Region: OpgC_C; cl00792
557598006293	Acyltransferase family; Region: Acyl_transf_3; pfam01757
557598006294	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423
557598006295	putative active site [active]
557598006296	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
557598006297	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
557598006298	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
557598006299	substrate binding site [chemical binding]; other site
557598006300	catalytic Zn binding site [ion binding]; other site
557598006301	NAD binding site [chemical binding]; other site
557598006302	structural Zn binding site [ion binding]; other site
557598006303	dimer interface [polypeptide binding]; other site
557598006304	Predicted esterase [General function prediction only]; Region: COG0627
557598006305	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598006306	protoporphyrinogen oxidase; Region: PLN02576
557598006307	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006308	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
557598006309	acyl-CoA binding pocket [chemical binding]; other site
557598006310	CoA binding site [chemical binding]; other site
557598006311	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
557598006312	tetramer interfaces [polypeptide binding]; other site
557598006313	binuclear metal-binding site [ion binding]; other site
557598006314	thiamine monophosphate kinase; Provisional; Region: PRK05731
557598006315	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
557598006316	ATP binding site [chemical binding]; other site
557598006317	dimerization interface [polypeptide binding]; other site
557598006318	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
557598006319	putative RNA binding site [nucleotide binding]; other site
557598006320	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
557598006321	homopentamer interface [polypeptide binding]; other site
557598006322	active site
557598006323	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
557598006324	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
557598006325	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
557598006326	dimerization interface [polypeptide binding]; other site
557598006327	active site
557598006328	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
557598006329	Ligand Binding Site [chemical binding]; other site
557598006330	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
557598006331	Lumazine binding domain; Region: Lum_binding; pfam00677
557598006332	Lumazine binding domain; Region: Lum_binding; pfam00677
557598006333	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
557598006334	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
557598006335	G1 box; other site
557598006336	putative GEF interaction site [polypeptide binding]; other site
557598006337	GTP/Mg2+ binding site [chemical binding]; other site
557598006338	Switch I region; other site
557598006339	G2 box; other site
557598006340	G3 box; other site
557598006341	Switch II region; other site
557598006342	G4 box; other site
557598006343	G5 box; other site
557598006344	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
557598006345	Mechanosensitive ion channel; Region: MS_channel; pfam00924
557598006346	Helix-turn-helix domains; Region: HTH; cl00088
557598006347	Bacterial transcriptional repressor; Region: TetR; pfam13972
557598006348	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
557598006349	DHH family; Region: DHH; pfam01368
557598006350	DHHA1 domain; Region: DHHA1; pfam02272
557598006351	Sulfatase; Region: Sulfatase; cl10460
557598006352	Peptidase family M23; Region: Peptidase_M23; pfam01551
557598006353	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
557598006354	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
557598006355	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598006356	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
557598006357	ferrochelatase; Reviewed; Region: hemH; PRK00035
557598006358	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
557598006359	C-terminal domain interface [polypeptide binding]; other site
557598006360	active site
557598006361	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
557598006362	active site
557598006363	N-terminal domain interface [polypeptide binding]; other site
557598006364	aminopeptidase N; Provisional; Region: pepN; PRK14015
557598006365	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
557598006366	active site
557598006367	Zn binding site [ion binding]; other site
557598006368	SCP-2 sterol transfer family; Region: SCP2; cl01225
557598006369	Transcriptional regulators [Transcription]; Region: GntR; COG1802
557598006370	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598006371	DNA-binding site [nucleotide binding]; DNA binding site
557598006372	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
557598006373	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
557598006374	ligand binding site [chemical binding]; other site
557598006375	flexible hinge region; other site
557598006376	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
557598006377	non-specific DNA interactions [nucleotide binding]; other site
557598006378	DNA binding site [nucleotide binding]
557598006379	sequence specific DNA binding site [nucleotide binding]; other site
557598006380	putative cAMP binding site [chemical binding]; other site
557598006381	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
557598006382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598006383	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
557598006384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006385	CoA-ligase; Region: Ligase_CoA; cl02894
557598006386	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
557598006387	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598006388	CoA-ligase; Region: Ligase_CoA; cl02894
557598006389	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
557598006390	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
557598006391	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
557598006392	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
557598006393	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
557598006394	E3 interaction surface; other site
557598006395	lipoyl attachment site [posttranslational modification]; other site
557598006396	e3 binding domain; Region: E3_binding; pfam02817
557598006397	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
557598006398	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
557598006399	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
557598006400	TPP-binding site [chemical binding]; other site
557598006401	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
557598006402	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
557598006403	dimer interface [polypeptide binding]; other site
557598006404	Citrate synthase; Region: Citrate_synt; pfam00285
557598006405	active site
557598006406	citrylCoA binding site [chemical binding]; other site
557598006407	NADH binding [chemical binding]; other site
557598006408	cationic pore residues; other site
557598006409	oxalacetate/citrate binding site [chemical binding]; other site
557598006410	coenzyme A binding site [chemical binding]; other site
557598006411	catalytic triad [active]
557598006412	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
557598006413	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
557598006414	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
557598006415	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
557598006416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006417	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
557598006418	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
557598006419	SdhC subunit interface [polypeptide binding]; other site
557598006420	proximal heme binding site [chemical binding]; other site
557598006421	cardiolipin binding site; other site
557598006422	Iron-sulfur protein interface; other site
557598006423	proximal quinone binding site [chemical binding]; other site
557598006424	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
557598006425	Iron-sulfur protein interface; other site
557598006426	proximal quinone binding site [chemical binding]; other site
557598006427	SdhD (CybS) interface [polypeptide binding]; other site
557598006428	proximal heme binding site [chemical binding]; other site
557598006429	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
557598006430	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598006431	DNA-binding site [nucleotide binding]; DNA binding site
557598006432	UTRA domain; Region: UTRA; cl01230
557598006433	malate dehydrogenase; Provisional; Region: PRK05442
557598006434	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
557598006435	NAD(P) binding site [chemical binding]; other site
557598006436	dimer interface [polypeptide binding]; other site
557598006437	malate binding site [chemical binding]; other site
557598006438	peptide chain release factor 2; Validated; Region: prfB; PRK00578
557598006439	RF-1 domain; Region: RF-1; cl02875
557598006440	RF-1 domain; Region: RF-1; cl02875
557598006441	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
557598006442	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
557598006443	dimer interface [polypeptide binding]; other site
557598006444	putative anticodon binding site; other site
557598006445	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
557598006446	motif 1; other site
557598006447	active site
557598006448	motif 2; other site
557598006449	motif 3; other site
557598006450	Cache domain; Region: Cache_1; pfam02743
557598006451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
557598006452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598006453	dimerization interface [polypeptide binding]; other site
557598006454	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598006455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598006456	dimer interface [polypeptide binding]; other site
557598006457	putative CheW interface [polypeptide binding]; other site
557598006458	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598006459	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
557598006460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598006461	active site
557598006462	phosphorylation site [posttranslational modification]
557598006463	intermolecular recognition site; other site
557598006464	dimerization interface [polypeptide binding]; other site
557598006465	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
557598006466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598006467	active site
557598006468	phosphorylation site [posttranslational modification]
557598006469	intermolecular recognition site; other site
557598006470	dimerization interface [polypeptide binding]; other site
557598006471	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
557598006472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598006473	active site
557598006474	phosphorylation site [posttranslational modification]
557598006475	intermolecular recognition site; other site
557598006476	dimerization interface [polypeptide binding]; other site
557598006477	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
557598006478	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
557598006479	putative binding surface; other site
557598006480	active site
557598006481	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
557598006482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598006483	ATP binding site [chemical binding]; other site
557598006484	Mg2+ binding site [ion binding]; other site
557598006485	G-X-G motif; other site
557598006486	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
557598006487	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
557598006488	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
557598006489	dimer interface [polypeptide binding]; other site
557598006490	active site
557598006491	heme binding site [chemical binding]; other site
557598006492	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
557598006493	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
557598006494	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
557598006495	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
557598006496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598006497	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598006498	metal binding site [ion binding]; metal-binding site
557598006499	active site
557598006500	I-site; other site
557598006501	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598006502	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
557598006503	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
557598006504	trimer interface [polypeptide binding]; other site
557598006505	eyelet of channel; other site
557598006506	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
557598006507	putative catalytic site [active]
557598006508	putative phosphate binding site [ion binding]; other site
557598006509	active site
557598006510	metal binding site A [ion binding]; metal-binding site
557598006511	DNA binding site [nucleotide binding]
557598006512	putative AP binding site [nucleotide binding]; other site
557598006513	putative metal binding site B [ion binding]; other site
557598006514	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
557598006515	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
557598006516	dimer interface [polypeptide binding]; other site
557598006517	anticodon binding site; other site
557598006518	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
557598006519	homodimer interface [polypeptide binding]; other site
557598006520	motif 1; other site
557598006521	active site
557598006522	motif 2; other site
557598006523	GAD domain; Region: GAD; pfam02938
557598006524	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
557598006525	motif 3; other site
557598006526	Protein of unknown function (DUF502); Region: DUF502; cl01107
557598006527	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
557598006528	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
557598006529	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
557598006530	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
557598006531	Acetokinase family; Region: Acetate_kinase; cl01029
557598006532	propionate/acetate kinase; Provisional; Region: PRK12379
557598006533	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598006534	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
557598006535	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
557598006536	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
557598006537	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598006538	dimer interface [polypeptide binding]; other site
557598006539	putative CheW interface [polypeptide binding]; other site
557598006540	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
557598006541	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
557598006542	Helix-turn-helix domains; Region: HTH; cl00088
557598006543	TOBE domain; Region: TOBE_2; cl01440
557598006544	TOBE domain; Region: TOBE_2; cl01440
557598006545	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
557598006546	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598006547	TOBE domain; Region: TOBE_2; cl01440
557598006548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598006549	dimer interface [polypeptide binding]; other site
557598006550	conserved gate region; other site
557598006551	putative PBP binding loops; other site
557598006552	ABC-ATPase subunit interface; other site
557598006553	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
557598006554	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598006555	Walker A/P-loop; other site
557598006556	ATP binding site [chemical binding]; other site
557598006557	Q-loop/lid; other site
557598006558	ABC transporter signature motif; other site
557598006559	Walker B; other site
557598006560	D-loop; other site
557598006561	H-loop/switch region; other site
557598006562	TOBE domain; Region: TOBE_2; cl01440
557598006563	Protein of unknown function (DUF523); Region: DUF523; cl00733
557598006564	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
557598006565	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
557598006566	active site
557598006567	Int/Topo IB signature motif; other site
557598006568	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
557598006569	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
557598006570	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
557598006571	Domain of unknown function (DUF927); Region: DUF927; cl12098
557598006572	DoxX; Region: DoxX; cl00976
557598006573	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
557598006574	catalytic residues [active]
557598006575	hypothetical protein; Region: PHA00675
557598006576	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
557598006577	signal recognition particle protein; Provisional; Region: PRK10867
557598006578	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
557598006579	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
557598006580	GTP binding site [chemical binding]; other site
557598006581	Signal peptide binding domain; Region: SRP_SPB; pfam02978
557598006582	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598006583	adenylosuccinate lyase; Provisional; Region: PRK09285
557598006584	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
557598006585	tetramer interface [polypeptide binding]; other site
557598006586	active site
557598006587	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
557598006588	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
557598006589	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
557598006590	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
557598006591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006592	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
557598006593	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598006594	alanine aminotransferase; Validated; Region: PRK08363
557598006595	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598006596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598006597	homodimer interface [polypeptide binding]; other site
557598006598	catalytic residue [active]
557598006599	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598006600	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
557598006601	substrate binding site [chemical binding]; other site
557598006602	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
557598006603	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
557598006604	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
557598006605	putative [Fe4-S4] binding site [ion binding]; other site
557598006606	putative molybdopterin cofactor binding site [chemical binding]; other site
557598006607	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
557598006608	putative molybdopterin cofactor binding site; other site
557598006609	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
557598006610	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
557598006611	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869
557598006612	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
557598006613	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
557598006614	sensor protein ZraS; Provisional; Region: PRK10364
557598006615	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
557598006616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598006617	active site
557598006618	phosphorylation site [posttranslational modification]
557598006619	intermolecular recognition site; other site
557598006620	dimerization interface [polypeptide binding]; other site
557598006621	Helix-turn-helix domains; Region: HTH; cl00088
557598006622	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
557598006623	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
557598006624	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
557598006625	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
557598006626	AMIN domain; Region: AMIN; pfam11741
557598006627	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
557598006628	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
557598006629	active site
557598006630	metal binding site [ion binding]; metal-binding site
557598006631	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
557598006632	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
557598006633	transmembrane helices; other site
557598006634	SlyX; Region: SlyX; cl01090
557598006635	Predicted membrane protein [Function unknown]; Region: COG4125
557598006636	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
557598006637	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
557598006638	Transcriptional regulator [Transcription]; Region: LysR; COG0583
557598006639	Helix-turn-helix domains; Region: HTH; cl00088
557598006640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
557598006641	dimerization interface [polypeptide binding]; other site
557598006642	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
557598006643	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
557598006644	nucleoside/Zn binding site; other site
557598006645	dimer interface [polypeptide binding]; other site
557598006646	catalytic motif [active]
557598006647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
557598006648	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
557598006649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
557598006650	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
557598006651	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
557598006652	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
557598006653	Tetramer interface [polypeptide binding]; other site
557598006654	active site
557598006655	FMN-binding site [chemical binding]; other site
557598006656	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
557598006657	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
557598006658	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
557598006659	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
557598006660	Spore Coat Protein U domain; Region: SCPU; cl02253
557598006661	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
557598006662	active site
557598006663	catalytic site [active]
557598006664	substrate binding site [chemical binding]; other site
557598006665	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
557598006666	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
557598006667	GIY-YIG motif/motif A; other site
557598006668	active site
557598006669	catalytic site [active]
557598006670	putative DNA binding site [nucleotide binding]; other site
557598006671	metal binding site [ion binding]; metal-binding site
557598006672	Phasin protein; Region: Phasin_2; cl11491
557598006673	septum formation inhibitor; Reviewed; Region: minC; PRK04516
557598006674	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
557598006675	cell division inhibitor MinD; Provisional; Region: PRK10818
557598006676	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
557598006677	Switch I; other site
557598006678	Switch II; other site
557598006679	Septum formation topological specificity factor MinE; Region: MinE; cl00538
557598006680	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
557598006681	Helix-turn-helix domains; Region: HTH; cl00088
557598006682	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
557598006683	dimerization interface [polypeptide binding]; other site
557598006684	multidrug efflux protein; Reviewed; Region: PRK01766
557598006685	MatE; Region: MatE; cl10513
557598006686	MatE; Region: MatE; cl10513
557598006687	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
557598006688	FAD binding domain; Region: FAD_binding_4; pfam01565
557598006689	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
557598006690	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
557598006691	hypothetical protein; Provisional; Region: PRK06132
557598006692	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
557598006693	Phosphate transporter family; Region: PHO4; cl00396
557598006694	Phosphate transporter family; Region: PHO4; cl00396
557598006695	putative transporter; Provisional; Region: PRK10504
557598006696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598006697	putative substrate translocation pore; other site
557598006698	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598006699	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
557598006700	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
557598006701	Fumarase C-terminus; Region: Fumerase_C; cl00795
557598006702	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
557598006703	Helix-turn-helix domains; Region: HTH; cl00088
557598006704	NAD-dependent deacetylase; Provisional; Region: PRK00481
557598006705	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
557598006706	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
557598006707	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
557598006708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598006709	catalytic residue [active]
557598006710	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
557598006711	DEAD-like helicases superfamily; Region: DEXDc; smart00487
557598006712	ATP binding site [chemical binding]; other site
557598006713	Mg++ binding site [ion binding]; other site
557598006714	motif III; other site
557598006715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598006716	nucleotide binding region [chemical binding]; other site
557598006717	ATP-binding site [chemical binding]; other site
557598006718	CobD/Cbib protein; Region: CobD_Cbib; cl00561
557598006719	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
557598006720	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
557598006721	hinge; other site
557598006722	active site
557598006723	BolA-like protein; Region: BolA; cl00386
557598006724	ABC-2 type transporter; Region: ABC2_membrane; cl11417
557598006725	ABC-2 type transporter; Region: ABC2_membrane; cl11417
557598006726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006727	Prephenate dehydrogenase; Region: PDH; pfam02153
557598006728	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
557598006729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598006730	catalytic residue [active]
557598006731	Uncharacterized conserved protein [Function unknown]; Region: COG5495
557598006732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006733	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
557598006734	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
557598006735	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
557598006736	homodimer interface [polypeptide binding]; other site
557598006737	substrate-cofactor binding pocket; other site
557598006738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598006739	catalytic residue [active]
557598006740	FOG: CBS domain [General function prediction only]; Region: COG0517
557598006741	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
557598006742	FOG: CBS domain [General function prediction only]; Region: COG0517
557598006743	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
557598006744	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598006745	PAS domain; Region: PAS_9; pfam13426
557598006746	putative active site [active]
557598006747	heme pocket [chemical binding]; other site
557598006748	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598006749	metal binding site [ion binding]; metal-binding site
557598006750	active site
557598006751	I-site; other site
557598006752	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598006753	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
557598006754	seryl-tRNA synthetase; Provisional; Region: PRK05431
557598006755	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
557598006756	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
557598006757	dimer interface [polypeptide binding]; other site
557598006758	active site
557598006759	motif 1; other site
557598006760	motif 2; other site
557598006761	motif 3; other site
557598006762	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
557598006763	EamA-like transporter family; Region: EamA; cl01037
557598006764	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
557598006765	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
557598006766	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
557598006767	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
557598006768	FAD binding domain; Region: FAD_binding_4; pfam01565
557598006769	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
557598006770	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
557598006771	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
557598006772	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
557598006773	MoxR-like ATPases [General function prediction only]; Region: COG0714
557598006774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598006775	Walker A motif; other site
557598006776	ATP binding site [chemical binding]; other site
557598006777	Walker B motif; other site
557598006778	arginine finger; other site
557598006779	ribonuclease R; Region: RNase_R; TIGR02063
557598006780	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
557598006781	RNB domain; Region: RNB; pfam00773
557598006782	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
557598006783	RNA binding site [nucleotide binding]; other site
557598006784	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
557598006785	putative tRNA-binding site [nucleotide binding]; other site
557598006786	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
557598006787	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
557598006788	B12 binding site [chemical binding]; other site
557598006789	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
557598006790	active site
557598006791	catalytic triad [active]
557598006792	oxyanion hole [active]
557598006793	EamA-like transporter family; Region: EamA; cl01037
557598006794	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
557598006795	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
557598006796	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
557598006797	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598006798	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
557598006799	Helix-turn-helix domains; Region: HTH; cl00088
557598006800	HipA-like N-terminal domain; Region: HipA_N; pfam07805
557598006801	HipA-like C-terminal domain; Region: HipA_C; pfam07804
557598006802	Phage-related protein [Function unknown]; Region: COG4695; cl01923
557598006803	phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540
557598006804	terminase ATPase subunit; Provisional; Region: P; PHA02535
557598006805	Helix-turn-helix domains; Region: HTH; cl00088
557598006806	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
557598006807	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
557598006808	terminase ATPase subunit; Provisional; Region: P; PHA02535
557598006809	Helix-turn-helix domains; Region: HTH; cl00088
557598006810	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
557598006811	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
557598006812	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
557598006813	terminase endonuclease subunit; Provisional; Region: M; PHA02537
557598006814	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
557598006815	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
557598006816	Phage Tail Protein X; Region: Phage_tail_X; cl02088
557598006817	Protein of unknown function (DUF754); Region: DUF754; pfam05449
557598006818	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
557598006819	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
557598006820	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
557598006821	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
557598006822	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
557598006823	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
557598006824	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
557598006825	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
557598006826	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
557598006827	Baseplate J-like protein; Region: Baseplate_J; cl01294
557598006828	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
557598006829	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
557598006830	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
557598006831	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
557598006832	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598006833	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
557598006834	Phage tail tube protein FII; Region: Phage_tube; cl01390
557598006835	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
557598006836	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
557598006837	Phage-related tail protein [Function unknown]; Region: COG5283
557598006838	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
557598006839	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
557598006840	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
557598006841	TIR domain; Region: TIR_2; cl15770
557598006842	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
557598006843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
557598006844	non-specific DNA binding site [nucleotide binding]; other site
557598006845	salt bridge; other site
557598006846	sequence-specific DNA binding site [nucleotide binding]; other site
557598006847	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
557598006848	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
557598006849	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
557598006850	active site
557598006851	DNA binding site [nucleotide binding]
557598006852	Int/Topo IB signature motif; other site
557598006853	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
557598006854	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
557598006855	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
557598006856	GIY-YIG motif/motif A; other site
557598006857	active site
557598006858	catalytic site [active]
557598006859	putative DNA binding site [nucleotide binding]; other site
557598006860	metal binding site [ion binding]; metal-binding site
557598006861	UvrB/uvrC motif; Region: UVR; pfam02151
557598006862	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
557598006863	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
557598006864	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
557598006865	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
557598006866	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
557598006867	active site
557598006868	Cupin superfamily protein; Region: Cupin_4; pfam08007
557598006869	JmjC domain, hydroxylase; Region: JmjC; cl15814
557598006870	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
557598006871	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
557598006872	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598006873	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
557598006874	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
557598006875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598006876	dimer interface [polypeptide binding]; other site
557598006877	conserved gate region; other site
557598006878	putative PBP binding loops; other site
557598006879	ABC-ATPase subunit interface; other site
557598006880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
557598006881	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
557598006882	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598006883	Walker A/P-loop; other site
557598006884	ATP binding site [chemical binding]; other site
557598006885	Q-loop/lid; other site
557598006886	ABC transporter signature motif; other site
557598006887	Walker B; other site
557598006888	D-loop; other site
557598006889	H-loop/switch region; other site
557598006890	TOBE domain; Region: TOBE_2; cl01440
557598006891	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
557598006892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598006893	Walker A motif; other site
557598006894	ATP binding site [chemical binding]; other site
557598006895	Walker B motif; other site
557598006896	arginine finger; other site
557598006897	Helix-turn-helix domains; Region: HTH; cl00088
557598006898	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423
557598006899	putative active site [active]
557598006900	ribonuclease PH; Reviewed; Region: rph; PRK00173
557598006901	Ribonuclease PH; Region: RNase_PH_bact; cd11362
557598006902	hexamer interface [polypeptide binding]; other site
557598006903	active site
557598006904	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598006905	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
557598006906	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598006907	metal binding site [ion binding]; metal-binding site
557598006908	active site
557598006909	I-site; other site
557598006910	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
557598006911	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
557598006912	GTP/Mg2+ binding site [chemical binding]; other site
557598006913	G4 box; other site
557598006914	G5 box; other site
557598006915	G1 box; other site
557598006916	Switch I region; other site
557598006917	G2 box; other site
557598006918	G3 box; other site
557598006919	Switch II region; other site
557598006920	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
557598006921	DNA photolyase; Region: DNA_photolyase; pfam00875
557598006922	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
557598006923	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
557598006924	FMN binding site [chemical binding]; other site
557598006925	active site
557598006926	substrate binding site [chemical binding]; other site
557598006927	catalytic residue [active]
557598006928	Sulfate transporter family; Region: Sulfate_transp; cl15842
557598006929	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
557598006930	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
557598006931	putative acyl-acceptor binding pocket; other site
557598006932	putative protease; Provisional; Region: PRK15452
557598006933	Peptidase family U32; Region: Peptidase_U32; cl03113
557598006934	Collagenase; Region: DUF3656; pfam12392
557598006935	PAS fold; Region: PAS_4; pfam08448
557598006936	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
557598006937	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598006938	metal binding site [ion binding]; metal-binding site
557598006939	active site
557598006940	I-site; other site
557598006941	Protein of unknown function (DUF917); Region: DUF917; pfam06032
557598006942	Protein of unknown function (DUF917); Region: DUF917; pfam06032
557598006943	OpgC protein; Region: OpgC_C; cl00792
557598006944	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
557598006945	ThiC-associated domain; Region: ThiC-associated; pfam13667
557598006946	ThiC family; Region: ThiC; cl08031
557598006947	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
557598006948	dimer interface [polypeptide binding]; other site
557598006949	substrate binding site [chemical binding]; other site
557598006950	ATP binding site [chemical binding]; other site
557598006951	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
557598006952	thiamine phosphate binding site [chemical binding]; other site
557598006953	active site
557598006954	pyrophosphate binding site [ion binding]; other site
557598006955	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
557598006956	substrate binding site [chemical binding]; other site
557598006957	multimerization interface [polypeptide binding]; other site
557598006958	ATP binding site [chemical binding]; other site
557598006959	EamA-like transporter family; Region: EamA; cl01037
557598006960	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
557598006961	EamA-like transporter family; Region: EamA; cl01037
557598006962	phosphoenolpyruvate synthase; Validated; Region: PRK06464
557598006963	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
557598006964	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
557598006965	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
557598006966	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
557598006967	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
557598006968	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
557598006969	dimer interface [polypeptide binding]; other site
557598006970	active site
557598006971	metal binding site [ion binding]; metal-binding site
557598006972	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
557598006973	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
557598006974	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
557598006975	active site
557598006976	HIGH motif; other site
557598006977	dimer interface [polypeptide binding]; other site
557598006978	KMSKS motif; other site
557598006979	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
557598006980	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
557598006981	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
557598006982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598006983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598006984	dimer interface [polypeptide binding]; other site
557598006985	conserved gate region; other site
557598006986	putative PBP binding loops; other site
557598006987	ABC-ATPase subunit interface; other site
557598006988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598006989	dimer interface [polypeptide binding]; other site
557598006990	conserved gate region; other site
557598006991	putative PBP binding loops; other site
557598006992	ABC-ATPase subunit interface; other site
557598006993	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598006994	ABC transporter signature motif; other site
557598006995	Walker B; other site
557598006996	D-loop; other site
557598006997	H-loop/switch region; other site
557598006998	TOBE domain; Region: TOBE_2; cl01440
557598006999	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
557598007000	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
557598007001	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598007002	catalytic residue [active]
557598007003	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598007004	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
557598007005	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
557598007006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598007008	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
557598007009	Ligand Binding Site [chemical binding]; other site
557598007010	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
557598007011	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
557598007012	FMN binding site [chemical binding]; other site
557598007013	substrate binding site [chemical binding]; other site
557598007014	putative catalytic residue [active]
557598007015	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598007016	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598007017	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598007018	dimer interface [polypeptide binding]; other site
557598007019	putative CheW interface [polypeptide binding]; other site
557598007020	Cache domain; Region: Cache_1; pfam02743
557598007021	AzlC protein; Region: AzlC; cl00570
557598007022	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
557598007023	EamA-like transporter family; Region: EamA; cl01037
557598007024	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
557598007025	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
557598007026	active site
557598007027	DNA polymerase III subunit delta'; Validated; Region: PRK08699
557598007028	thymidylate kinase; Validated; Region: tmk; PRK00698
557598007029	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
557598007030	TMP-binding site; other site
557598007031	ATP-binding site [chemical binding]; other site
557598007032	YceG-like family; Region: YceG; pfam02618
557598007033	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
557598007034	dimerization interface [polypeptide binding]; other site
557598007035	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
557598007036	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
557598007037	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
557598007038	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
557598007039	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
557598007040	flagellar capping protein; Reviewed; Region: fliD; PRK08032
557598007041	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
557598007042	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
557598007043	FlaG protein; Region: FlaG; cl00591
557598007044	flagellin; Provisional; Region: PRK12802
557598007045	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
557598007046	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
557598007047	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
557598007048	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598007049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007050	Integrase core domain; Region: rve; cl01316
557598007051	Integrase core domain; Region: rve_3; cl15866
557598007052	Transposase domain (DUF772); Region: DUF772; cl15789
557598007053	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
557598007054	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
557598007055	substrate binding site; other site
557598007056	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
557598007057	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
557598007058	NAD binding site [chemical binding]; other site
557598007059	homotetramer interface [polypeptide binding]; other site
557598007060	homodimer interface [polypeptide binding]; other site
557598007061	substrate binding site [chemical binding]; other site
557598007062	active site
557598007063	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
557598007064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007065	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
557598007066	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
557598007067	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
557598007068	inhibitor-cofactor binding pocket; inhibition site
557598007069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598007070	catalytic residue [active]
557598007071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
557598007072	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598007073	HTH-like domain; Region: HTH_21; pfam13276
557598007074	Integrase core domain; Region: rve; cl01316
557598007075	Integrase core domain; Region: rve_3; cl15866
557598007076	Helix-turn-helix domains; Region: HTH; cl00088
557598007077	glycine dehydrogenase; Provisional; Region: PRK05367
557598007078	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598007079	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598007080	catalytic residue [active]
557598007081	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
557598007082	tetramer interface [polypeptide binding]; other site
557598007083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598007084	catalytic residue [active]
557598007085	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
557598007086	lipoyl attachment site [posttranslational modification]; other site
557598007087	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
557598007088	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
557598007089	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
557598007090	heme binding pocket [chemical binding]; other site
557598007091	heme ligand [chemical binding]; other site
557598007092	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
557598007093	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598007094	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
557598007095	putative substrate binding site [chemical binding]; other site
557598007096	nucleotide binding site [chemical binding]; other site
557598007097	nucleotide binding site [chemical binding]; other site
557598007098	homodimer interface [polypeptide binding]; other site
557598007099	ornithine carbamoyltransferase; Validated; Region: PRK02102
557598007100	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
557598007101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007102	Amidinotransferase; Region: Amidinotransf; cl12043
557598007103	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
557598007104	arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810
557598007105	Spore germination protein; Region: Spore_permease; cl15802
557598007106	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
557598007107	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
557598007108	putative substrate binding site [chemical binding]; other site
557598007109	nucleotide binding site [chemical binding]; other site
557598007110	nucleotide binding site [chemical binding]; other site
557598007111	homodimer interface [polypeptide binding]; other site
557598007112	ornithine carbamoyltransferase; Validated; Region: PRK02102
557598007113	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
557598007114	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007115	Amidinotransferase; Region: Amidinotransf; cl12043
557598007116	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
557598007117	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
557598007118	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
557598007119	metal ion-dependent adhesion site (MIDAS); other site
557598007120	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
557598007121	type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
557598007122	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
557598007123	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
557598007124	chaperone protein DnaJ; Provisional; Region: PRK10767
557598007125	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
557598007126	HSP70 interaction site [polypeptide binding]; other site
557598007127	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
557598007128	substrate binding site [polypeptide binding]; other site
557598007129	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
557598007130	Zn binding sites [ion binding]; other site
557598007131	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
557598007132	dimer interface [polypeptide binding]; other site
557598007133	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
557598007134	heat shock protein GrpE; Provisional; Region: PRK14140
557598007135	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
557598007136	dimer interface [polypeptide binding]; other site
557598007137	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
557598007138	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
557598007139	tetramer interface [polypeptide binding]; other site
557598007140	active site
557598007141	Mg2+/Mn2+ binding site [ion binding]; other site
557598007142	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598007143	Walker A/P-loop; other site
557598007144	ATP binding site [chemical binding]; other site
557598007145	Q-loop/lid; other site
557598007146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598007147	dimer interface [polypeptide binding]; other site
557598007148	conserved gate region; other site
557598007149	putative PBP binding loops; other site
557598007150	ABC-ATPase subunit interface; other site
557598007151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598007152	dimer interface [polypeptide binding]; other site
557598007153	conserved gate region; other site
557598007154	putative PBP binding loops; other site
557598007155	ABC-ATPase subunit interface; other site
557598007156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598007157	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
557598007158	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
557598007159	IHF - DNA interface [nucleotide binding]; other site
557598007160	IHF dimer interface [polypeptide binding]; other site
557598007161	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
557598007162	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
557598007163	putative tRNA-binding site [nucleotide binding]; other site
557598007164	B3/4 domain; Region: B3_4; cl11458
557598007165	tRNA synthetase B5 domain; Region: B5; cl08394
557598007166	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
557598007167	dimer interface [polypeptide binding]; other site
557598007168	motif 1; other site
557598007169	motif 3; other site
557598007170	motif 2; other site
557598007171	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
557598007172	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
557598007173	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
557598007174	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
557598007175	dimer interface [polypeptide binding]; other site
557598007176	motif 1; other site
557598007177	active site
557598007178	motif 2; other site
557598007179	motif 3; other site
557598007180	ribosomal protein L20; Region: rpl20; CHL00068
557598007181	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
557598007182	23S rRNA binding site [nucleotide binding]; other site
557598007183	L21 binding site [polypeptide binding]; other site
557598007184	L13 binding site [polypeptide binding]; other site
557598007185	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
557598007186	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
557598007187	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
557598007188	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
557598007189	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
557598007190	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
557598007191	active site
557598007192	dimer interface [polypeptide binding]; other site
557598007193	motif 1; other site
557598007194	motif 2; other site
557598007195	motif 3; other site
557598007196	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
557598007197	anticodon binding site; other site
557598007198	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
557598007199	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
557598007200	Preprotein translocase subunit; Region: YajC; cl00806
557598007201	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
557598007202	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
557598007203	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
557598007204	Protein export membrane protein; Region: SecD_SecF; cl14618
557598007205	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
557598007206	dimerization interface [polypeptide binding]; other site
557598007207	putative DNA binding site [nucleotide binding]; other site
557598007208	putative Zn2+ binding site [ion binding]; other site
557598007209	Sulfatase; Region: Sulfatase; cl10460
557598007210	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
557598007211	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598007212	Peptidase family M23; Region: Peptidase_M23; pfam01551
557598007213	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
557598007214	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
557598007215	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
557598007216	protein binding site [polypeptide binding]; other site
557598007217	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
557598007218	Catalytic dyad [active]
557598007219	N-acetylglutamate synthase; Validated; Region: PRK05279
557598007220	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
557598007221	putative feedback inhibition sensing region; other site
557598007222	putative nucleotide binding site [chemical binding]; other site
557598007223	putative substrate binding site [chemical binding]; other site
557598007224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
557598007225	Coenzyme A binding pocket [chemical binding]; other site
557598007226	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
557598007227	UDP-glucose 4-epimerase; Region: PLN02240
557598007228	NAD binding site [chemical binding]; other site
557598007229	homodimer interface [polypeptide binding]; other site
557598007230	active site
557598007231	substrate binding site [chemical binding]; other site
557598007232	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
557598007233	heterotetramer interface [polypeptide binding]; other site
557598007234	active site pocket [active]
557598007235	cleavage site
557598007236	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
557598007237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598007238	ATP binding site [chemical binding]; other site
557598007239	putative Mg++ binding site [ion binding]; other site
557598007240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598007241	nucleotide binding region [chemical binding]; other site
557598007242	ATP-binding site [chemical binding]; other site
557598007243	RQC domain; Region: RQC; cl09632
557598007244	HRDC domain; Region: HRDC; cl02578
557598007245	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
557598007246	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
557598007247	P-loop; other site
557598007248	Magnesium ion binding site [ion binding]; other site
557598007249	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
557598007250	Magnesium ion binding site [ion binding]; other site
557598007251	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
557598007252	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
557598007253	ssDNA binding site; other site
557598007254	generic binding surface II; other site
557598007255	DEAD-like helicases superfamily; Region: DEXDc; smart00487
557598007256	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598007257	ATP binding site [chemical binding]; other site
557598007258	putative Mg++ binding site [ion binding]; other site
557598007259	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598007260	nucleotide binding region [chemical binding]; other site
557598007261	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
557598007262	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
557598007263	23S rRNA interface [nucleotide binding]; other site
557598007264	L3 interface [polypeptide binding]; other site
557598007265	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
557598007266	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
557598007267	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
557598007268	synthetase active site [active]
557598007269	NTP binding site [chemical binding]; other site
557598007270	metal binding site [ion binding]; metal-binding site
557598007271	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
557598007272	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
557598007273	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
557598007274	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
557598007275	minor groove reading motif; other site
557598007276	helix-hairpin-helix signature motif; other site
557598007277	substrate binding pocket [chemical binding]; other site
557598007278	active site
557598007279	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
557598007280	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
557598007281	DNA binding and oxoG recognition site [nucleotide binding]
557598007282	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
557598007283	THUMP domain; Region: THUMP; cl12076
557598007284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007285	MarC family integral membrane protein; Region: MarC; cl00919
557598007286	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
557598007287	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
557598007288	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
557598007289	NAD(P) binding site [chemical binding]; other site
557598007290	homodimer interface [polypeptide binding]; other site
557598007291	substrate binding site [chemical binding]; other site
557598007292	active site
557598007293	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
557598007294	Mg++ binding site [ion binding]; other site
557598007295	putative catalytic motif [active]
557598007296	putative substrate binding site [chemical binding]; other site
557598007297	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
557598007298	putative glycosyl transferase; Provisional; Region: PRK10307
557598007299	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598007300	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
557598007301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
557598007302	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
557598007303	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
557598007304	active site
557598007305	dimer interface [polypeptide binding]; other site
557598007306	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
557598007307	Ligand Binding Site [chemical binding]; other site
557598007308	Molecular Tunnel; other site
557598007309	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
557598007310	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
557598007311	active site
557598007312	dimer interface [polypeptide binding]; other site
557598007313	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
557598007314	Ligand Binding Site [chemical binding]; other site
557598007315	Molecular Tunnel; other site
557598007316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598007317	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598007318	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
557598007319	active site
557598007320	catalytic triad [active]
557598007321	oxyanion hole [active]
557598007322	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_6; cd08820
557598007323	putative active site [active]
557598007324	putative substrate binding site [chemical binding]; other site
557598007325	putative cosubstrate binding site; other site
557598007326	catalytic site [active]
557598007327	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
557598007328	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
557598007329	Walker A/P-loop; other site
557598007330	ATP binding site [chemical binding]; other site
557598007331	Q-loop/lid; other site
557598007332	ABC transporter signature motif; other site
557598007333	Walker B; other site
557598007334	D-loop; other site
557598007335	H-loop/switch region; other site
557598007336	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
557598007337	putative carbohydrate binding site [chemical binding]; other site
557598007338	ABC-2 type transporter; Region: ABC2_membrane; cl11417
557598007339	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
557598007340	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007341	NAD(P) binding site [chemical binding]; other site
557598007342	active site
557598007343	Bordetella bronchiseptica enzymes WbmH and WbmG-like, extended (e) SDRs; Region: WbmH_like_SDR_e; cd08957
557598007344	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
557598007345	NAD binding site [chemical binding]; other site
557598007346	homodimer interface [polypeptide binding]; other site
557598007347	active site
557598007348	putative substrate binding site [chemical binding]; other site
557598007349	Bordetella bronchiseptica enzymes WbmH and WbmG-like, extended (e) SDRs; Region: WbmH_like_SDR_e; cd08957
557598007350	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
557598007351	NAD binding site [chemical binding]; other site
557598007352	homodimer interface [polypeptide binding]; other site
557598007353	active site
557598007354	putative substrate binding site [chemical binding]; other site
557598007355	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
557598007356	active site
557598007357	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
557598007358	homodimer interface [polypeptide binding]; other site
557598007359	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
557598007360	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
557598007361	inhibitor-cofactor binding pocket; inhibition site
557598007362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598007363	catalytic residue [active]
557598007364	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
557598007365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007366	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
557598007367	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
557598007368	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
557598007369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007370	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
557598007371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
557598007372	putative DNA binding site [nucleotide binding]; other site
557598007373	putative Zn2+ binding site [ion binding]; other site
557598007374	Helix-turn-helix domains; Region: HTH; cl00088
557598007375	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
557598007376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598007377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
557598007378	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
557598007379	putative metal binding site [ion binding]; other site
557598007380	putative homodimer interface [polypeptide binding]; other site
557598007381	putative homotetramer interface [polypeptide binding]; other site
557598007382	putative homodimer-homodimer interface [polypeptide binding]; other site
557598007383	putative allosteric switch controlling residues; other site
557598007384	High-affinity nickel-transport protein; Region: NicO; cl00964
557598007385	High-affinity nickel-transport protein; Region: NicO; cl00964
557598007386	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
557598007387	transcriptional activator RfaH; Region: RfaH; TIGR01955
557598007388	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598007389	PAS domain; Region: PAS_9; pfam13426
557598007390	putative active site [active]
557598007391	heme pocket [chemical binding]; other site
557598007392	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
557598007393	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598007394	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
557598007395	Zn2+ binding site [ion binding]; other site
557598007396	Mg2+ binding site [ion binding]; other site
557598007397	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
557598007398	MltA specific insert domain; Region: MltA; cl08398
557598007399	3D domain; Region: 3D; cl01439
557598007400	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598007401	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007402	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007403	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
557598007404	Protein export membrane protein; Region: SecD_SecF; cl14618
557598007405	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
557598007406	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
557598007407	substrate binding site [chemical binding]; other site
557598007408	active site
557598007409	primosome assembly protein PriA; Validated; Region: PRK05580
557598007410	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
557598007411	ATP binding site [chemical binding]; other site
557598007412	putative Mg++ binding site [ion binding]; other site
557598007413	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598007414	ATP-binding site [chemical binding]; other site
557598007415	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
557598007416	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
557598007417	tetramerization interface [polypeptide binding]; other site
557598007418	NAD(P) binding site [chemical binding]; other site
557598007419	catalytic residues [active]
557598007420	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
557598007421	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
557598007422	inhibitor-cofactor binding pocket; inhibition site
557598007423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598007424	catalytic residue [active]
557598007425	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
557598007426	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
557598007427	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
557598007428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
557598007429	Helix-turn-helix domains; Region: HTH; cl00088
557598007430	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
557598007431	feedback inhibition sensing region; other site
557598007432	homohexameric interface [polypeptide binding]; other site
557598007433	nucleotide binding site [chemical binding]; other site
557598007434	N-acetyl-L-glutamate binding site [chemical binding]; other site
557598007435	FOG: CBS domain [General function prediction only]; Region: COG0517
557598007436	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
557598007437	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
557598007438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
557598007439	motif II; other site
557598007440	VanZ like family; Region: VanZ; cl01971
557598007441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598007442	dimer interface [polypeptide binding]; other site
557598007443	putative CheW interface [polypeptide binding]; other site
557598007444	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
557598007445	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
557598007446	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598007447	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
557598007448	GSH binding site [chemical binding]; other site
557598007449	catalytic residues [active]
557598007450	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
557598007451	SecA binding site; other site
557598007452	Preprotein binding site; other site
557598007453	Bacterial SH3 domain; Region: SH3_3; cl02551
557598007454	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
557598007455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007456	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
557598007457	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
557598007458	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
557598007459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
557598007460	DNA-binding site [nucleotide binding]; DNA binding site
557598007461	FCD domain; Region: FCD; cl11656
557598007462	Cysteine-rich domain; Region: CCG; pfam02754
557598007463	Cysteine-rich domain; Region: CCG; pfam02754
557598007464	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
557598007465	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
557598007466	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
557598007467	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
557598007468	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
557598007469	FAD binding domain; Region: FAD_binding_4; pfam01565
557598007470	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
557598007471	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
557598007472	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
557598007473	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
557598007474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007475	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
557598007476	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
557598007477	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
557598007478	RmuC family; Region: RmuC; pfam02646
557598007479	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
557598007480	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598007481	metal binding site [ion binding]; metal-binding site
557598007482	active site
557598007483	I-site; other site
557598007484	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598007485	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
557598007486	trimer interface [polypeptide binding]; other site
557598007487	active site
557598007488	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
557598007489	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
557598007490	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
557598007491	Isochorismatase family; Region: Isochorismatase; pfam00857
557598007492	catalytic triad [active]
557598007493	dimer interface [polypeptide binding]; other site
557598007494	conserved cis-peptide bond; other site
557598007495	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820
557598007496	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
557598007497	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
557598007498	putative deacylase active site [active]
557598007499	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
557598007500	catalytic loop [active]
557598007501	iron binding site [ion binding]; other site
557598007502	chaperone protein HscA; Provisional; Region: hscA; PRK05183
557598007503	co-chaperone HscB; Provisional; Region: hscB; PRK03578
557598007504	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
557598007505	HSP70 interaction site [polypeptide binding]; other site
557598007506	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
557598007507	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
557598007508	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
557598007509	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
557598007510	trimerization site [polypeptide binding]; other site
557598007511	active site
557598007512	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
557598007513	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
557598007514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
557598007515	catalytic residue [active]
557598007516	Helix-turn-helix domains; Region: HTH; cl00088
557598007517	Rrf2 family protein; Region: rrf2_super; TIGR00738
557598007518	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
557598007519	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
557598007520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007521	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
557598007522	Helix-turn-helix domains; Region: HTH; cl00088
557598007523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007524	NAD(P) binding site [chemical binding]; other site
557598007525	active site
557598007526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598007527	active site
557598007528	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
557598007529	active site
557598007530	tetramer interface; other site
557598007531	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
557598007532	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
557598007533	nucleotide binding pocket [chemical binding]; other site
557598007534	K-X-D-G motif; other site
557598007535	catalytic site [active]
557598007536	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
557598007537	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
557598007538	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
557598007539	Dimer interface [polypeptide binding]; other site
557598007540	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
557598007541	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
557598007542	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
557598007543	Walker A/P-loop; other site
557598007544	ATP binding site [chemical binding]; other site
557598007545	Q-loop/lid; other site
557598007546	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
557598007547	ABC transporter signature motif; other site
557598007548	Walker B; other site
557598007549	D-loop; other site
557598007550	H-loop/switch region; other site
557598007551	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
557598007552	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
557598007553	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
557598007554	Stringent starvation protein B; Region: SspB; cl01120
557598007555	stringent starvation protein A; Provisional; Region: sspA; PRK09481
557598007556	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
557598007557	C-terminal domain interface [polypeptide binding]; other site
557598007558	putative GSH binding site (G-site) [chemical binding]; other site
557598007559	dimer interface [polypeptide binding]; other site
557598007560	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
557598007561	dimer interface [polypeptide binding]; other site
557598007562	N-terminal domain interface [polypeptide binding]; other site
557598007563	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
557598007564	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
557598007565	Qi binding site; other site
557598007566	intrachain domain interface; other site
557598007567	interchain domain interface [polypeptide binding]; other site
557598007568	cytochrome b; Provisional; Region: CYTB; MTH00156
557598007569	heme bH binding site [chemical binding]; other site
557598007570	heme bL binding site [chemical binding]; other site
557598007571	Qo binding site; other site
557598007572	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
557598007573	interchain domain interface [polypeptide binding]; other site
557598007574	intrachain domain interface; other site
557598007575	Qi binding site; other site
557598007576	Qo binding site; other site
557598007577	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
557598007578	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
557598007579	[2Fe-2S] cluster binding site [ion binding]; other site
557598007580	Uncharacterized conserved protein [Function unknown]; Region: COG0327
557598007581	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
557598007582	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
557598007583	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007584	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
557598007585	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
557598007586	acyl-coenzyme A oxidase; Region: PLN02526
557598007587	FAD binding site [chemical binding]; other site
557598007588	substrate binding pocket [chemical binding]; other site
557598007589	catalytic base [active]
557598007590	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
557598007591	dimer interface [polypeptide binding]; other site
557598007592	active site
557598007593	aspartate-rich active site metal binding site; other site
557598007594	allosteric magnesium binding site [ion binding]; other site
557598007595	Schiff base residues; other site
557598007596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598007597	dimerization interface [polypeptide binding]; other site
557598007598	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598007599	metal binding site [ion binding]; metal-binding site
557598007600	active site
557598007601	I-site; other site
557598007602	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598007603	NMT1-like family; Region: NMT1_2; cl15260
557598007604	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
557598007605	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
557598007606	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
557598007607	active site
557598007608	substrate binding site [chemical binding]; other site
557598007609	metal binding site [ion binding]; metal-binding site
557598007610	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
557598007611	dihydropteroate synthase; Region: DHPS; TIGR01496
557598007612	substrate binding pocket [chemical binding]; other site
557598007613	dimer interface [polypeptide binding]; other site
557598007614	inhibitor binding site; inhibition site
557598007615	FtsH Extracellular; Region: FtsH_ext; pfam06480
557598007616	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
557598007617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598007618	Walker A motif; other site
557598007619	ATP binding site [chemical binding]; other site
557598007620	Walker B motif; other site
557598007621	arginine finger; other site
557598007622	Peptidase family M41; Region: Peptidase_M41; pfam01434
557598007623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598007624	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
557598007625	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
557598007626	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
557598007627	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
557598007628	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
557598007629	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
557598007630	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
557598007631	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
557598007632	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598007633	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
557598007634	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
557598007635	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598007636	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
557598007637	IMP binding site; other site
557598007638	dimer interface [polypeptide binding]; other site
557598007639	interdomain contacts; other site
557598007640	partial ornithine binding site; other site
557598007641	LysE type translocator; Region: LysE; cl00565
557598007642	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
557598007643	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
557598007644	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
557598007645	catalytic site [active]
557598007646	subunit interface [polypeptide binding]; other site
557598007647	Sulfatase; Region: Sulfatase; cl10460
557598007648	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
557598007649	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
557598007650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
557598007651	active site
557598007652	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
557598007653	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
557598007654	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
557598007655	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
557598007656	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
557598007657	Electron transfer flavoprotein domain; Region: ETF; pfam01012
557598007658	Ligand binding site [chemical binding]; other site
557598007659	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
557598007660	dimer interaction site [polypeptide binding]; other site
557598007661	substrate-binding tunnel; other site
557598007662	active site
557598007663	catalytic site [active]
557598007664	substrate binding site [chemical binding]; other site
557598007665	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
557598007666	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
557598007667	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598007668	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598007669	metal binding site [ion binding]; metal-binding site
557598007670	active site
557598007671	I-site; other site
557598007672	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598007673	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
557598007674	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
557598007675	metal ion-dependent adhesion site (MIDAS); other site
557598007676	PA14 domain; Region: PA14; cl08459
557598007677	Hemolysin-type calcium-binding repeat (2 copies); Region: HemolysinCabind; pfam00353
557598007678	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
557598007679	type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
557598007680	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
557598007681	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
557598007682	DNA binding residues [nucleotide binding]
557598007683	dimerization interface [polypeptide binding]; other site
557598007684	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
557598007685	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007686	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007687	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421
557598007688	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
557598007689	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598007690	ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
557598007691	Walker A/P-loop; other site
557598007692	ATP binding site [chemical binding]; other site
557598007693	Q-loop/lid; other site
557598007694	ABC transporter signature motif; other site
557598007695	Walker B; other site
557598007696	D-loop; other site
557598007697	H-loop/switch region; other site
557598007698	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
557598007699	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
557598007700	active site
557598007701	Zn binding site [ion binding]; other site
557598007702	Ion channel; Region: Ion_trans_2; cl11596
557598007703	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
557598007704	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
557598007705	trimer interface [polypeptide binding]; other site
557598007706	putative metal binding site [ion binding]; other site
557598007707	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
557598007708	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
557598007709	Helix-turn-helix domains; Region: HTH; cl00088
557598007710	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
557598007711	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
557598007712	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007713	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598007714	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
557598007715	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598007716	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
557598007717	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
557598007718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598007719	homodimer interface [polypeptide binding]; other site
557598007720	catalytic residue [active]
557598007721	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
557598007722	Nitrogen regulatory protein P-II; Region: P-II; cl00412
557598007723	Nitrogen regulatory protein P-II; Region: P-II; smart00938
557598007724	Membrane fusogenic activity; Region: BMFP; cl01115
557598007725	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
557598007726	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
557598007727	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598007728	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
557598007729	Sporulation related domain; Region: SPOR; cl10051
557598007730	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
557598007731	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
557598007732	catalytic residues [active]
557598007733	hinge region; other site
557598007734	alpha helical domain; other site
557598007735	Bacitracin resistance protein BacA; Region: BacA; cl00858
557598007736	Cytochrome c; Region: Cytochrom_C; cl11414
557598007737	Cytochrome c; Region: Cytochrom_C; cl11414
557598007738	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
557598007739	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
557598007740	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
557598007741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007742	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
557598007743	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
557598007744	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
557598007745	active pocket/dimerization site; other site
557598007746	active site
557598007747	phosphorylation site [posttranslational modification]
557598007748	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
557598007749	dimerization domain swap beta strand [polypeptide binding]; other site
557598007750	regulatory protein interface [polypeptide binding]; other site
557598007751	active site
557598007752	regulatory phosphorylation site [posttranslational modification]; other site
557598007753	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
557598007754	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
557598007755	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
557598007756	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
557598007757	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
557598007758	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
557598007759	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
557598007760	Walker A/P-loop; other site
557598007761	ATP binding site [chemical binding]; other site
557598007762	Q-loop/lid; other site
557598007763	ABC transporter signature motif; other site
557598007764	Walker B; other site
557598007765	D-loop; other site
557598007766	H-loop/switch region; other site
557598007767	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
557598007768	putative metal binding site; other site
557598007769	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
557598007770	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598007771	active site
557598007772	O-Antigen ligase; Region: Wzy_C; cl04850
557598007773	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
557598007774	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
557598007775	active site
557598007776	dimer interface [polypeptide binding]; other site
557598007777	metal binding site [ion binding]; metal-binding site
557598007778	shikimate kinase; Reviewed; Region: aroK; PRK00131
557598007779	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
557598007780	ADP binding site [chemical binding]; other site
557598007781	magnesium binding site [ion binding]; other site
557598007782	putative shikimate binding site; other site
557598007783	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
557598007784	Transglycosylase; Region: Transgly; cl07896
557598007785	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598007786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598007787	S-adenosylmethionine binding site [chemical binding]; other site
557598007788	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598007789	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
557598007790	radical SAM protein, TIGR01212 family; Region: TIGR01212
557598007791	phosphoethanolamine transferase; Provisional; Region: PRK11560
557598007792	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
557598007793	Sulfatase; Region: Sulfatase; cl10460
557598007794	Mechanosensitive ion channel; Region: MS_channel; pfam00924
557598007795	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
557598007796	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
557598007797	substrate binding pocket [chemical binding]; other site
557598007798	chain length determination region; other site
557598007799	substrate-Mg2+ binding site; other site
557598007800	catalytic residues [active]
557598007801	aspartate-rich region 1; other site
557598007802	active site lid residues [active]
557598007803	aspartate-rich region 2; other site
557598007804	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
557598007805	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
557598007806	GTPase CgtA; Reviewed; Region: obgE; PRK12299
557598007807	GTP1/OBG; Region: GTP1_OBG; pfam01018
557598007808	Obg GTPase; Region: Obg; cd01898
557598007809	G1 box; other site
557598007810	GTP/Mg2+ binding site [chemical binding]; other site
557598007811	Switch I region; other site
557598007812	G2 box; other site
557598007813	G3 box; other site
557598007814	Switch II region; other site
557598007815	G4 box; other site
557598007816	G5 box; other site
557598007817	muropeptide transporter; Validated; Region: ampG; PRK11010
557598007818	AmpG-related permease; Region: 2A0125; TIGR00901
557598007819	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
557598007820	putative deacylase active site [active]
557598007821	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
557598007822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598007823	putative substrate translocation pore; other site
557598007824	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
557598007825	ArsC family; Region: ArsC; pfam03960
557598007826	catalytic residues [active]
557598007827	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
557598007828	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
557598007829	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
557598007830	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
557598007831	EamA-like transporter family; Region: EamA; cl01037
557598007832	EamA-like transporter family; Region: EamA; cl01037
557598007833	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
557598007834	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
557598007835	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
557598007836	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
557598007837	Zn2+ binding site [ion binding]; other site
557598007838	Mg2+ binding site [ion binding]; other site
557598007839	DNA polymerase I; Provisional; Region: PRK05755
557598007840	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
557598007841	active site
557598007842	metal binding site 1 [ion binding]; metal-binding site
557598007843	putative 5' ssDNA interaction site; other site
557598007844	metal binding site 3; metal-binding site
557598007845	metal binding site 2 [ion binding]; metal-binding site
557598007846	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
557598007847	putative DNA binding site [nucleotide binding]; other site
557598007848	putative metal binding site [ion binding]; other site
557598007849	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
557598007850	active site
557598007851	catalytic site [active]
557598007852	substrate binding site [chemical binding]; other site
557598007853	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
557598007854	active site
557598007855	DNA binding site [nucleotide binding]
557598007856	catalytic site [active]
557598007857	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
557598007858	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
557598007859	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
557598007860	Phosphotransferase enzyme family; Region: APH; pfam01636
557598007861	putative active site [active]
557598007862	putative substrate binding site [chemical binding]; other site
557598007863	ATP binding site [chemical binding]; other site
557598007864	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
557598007865	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
557598007866	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
557598007867	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598007868	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
557598007869	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
557598007870	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
557598007871	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
557598007872	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
557598007873	FAD binding pocket [chemical binding]; other site
557598007874	FAD binding motif [chemical binding]; other site
557598007875	phosphate binding motif [ion binding]; other site
557598007876	beta-alpha-beta structure motif; other site
557598007877	NAD binding pocket [chemical binding]; other site
557598007878	Cupin domain; Region: Cupin_2; cl09118
557598007879	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
557598007880	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
557598007881	substrate binding site; other site
557598007882	tetramer interface; other site
557598007883	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
557598007884	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
557598007885	NADP binding site [chemical binding]; other site
557598007886	active site
557598007887	putative substrate binding site [chemical binding]; other site
557598007888	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
557598007889	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
557598007890	NAD binding site [chemical binding]; other site
557598007891	substrate binding site [chemical binding]; other site
557598007892	homodimer interface [polypeptide binding]; other site
557598007893	active site
557598007894	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
557598007895	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
557598007896	glutaminase active site [active]
557598007897	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
557598007898	dimer interface [polypeptide binding]; other site
557598007899	active site
557598007900	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
557598007901	dimer interface [polypeptide binding]; other site
557598007902	active site
557598007903	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
557598007904	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
557598007905	Substrate binding site; other site
557598007906	Mg++ binding site; other site
557598007907	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
557598007908	active site
557598007909	substrate binding site [chemical binding]; other site
557598007910	CoA binding site [chemical binding]; other site
557598007911	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
557598007912	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
557598007913	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
557598007914	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
557598007915	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
557598007916	alpha subunit interaction interface [polypeptide binding]; other site
557598007917	Walker A motif; other site
557598007918	ATP binding site [chemical binding]; other site
557598007919	Walker B motif; other site
557598007920	inhibitor binding site; inhibition site
557598007921	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
557598007922	ATP synthase; Region: ATP-synt; cl00365
557598007923	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
557598007924	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
557598007925	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
557598007926	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
557598007927	beta subunit interaction interface [polypeptide binding]; other site
557598007928	Walker A motif; other site
557598007929	ATP binding site [chemical binding]; other site
557598007930	Walker B motif; other site
557598007931	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
557598007932	Plant ATP synthase F0; Region: YMF19; cl07975
557598007933	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
557598007934	Plant ATP synthase F0; Region: YMF19; cl07975
557598007935	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
557598007936	ATP synthase subunit C; Region: ATP-synt_C; cl00466
557598007937	ATP synthase A chain; Region: ATP-synt_A; cl00413
557598007938	ATP synthase I chain; Region: ATP_synt_I; cl09170
557598007939	ParB-like partition proteins; Region: parB_part; TIGR00180
557598007940	ParB-like nuclease domain; Region: ParBc; cl02129
557598007941	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
557598007942	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
557598007943	P-loop; other site
557598007944	Magnesium ion binding site [ion binding]; other site
557598007945	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
557598007946	Magnesium ion binding site [ion binding]; other site
557598007947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598007948	S-adenosylmethionine binding site [chemical binding]; other site
557598007949	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
557598007950	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598007951	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
557598007952	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
557598007953	Protein of unknown function (DUF445); Region: DUF445; pfam04286
557598007954	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
557598007955	homodimer interaction site [polypeptide binding]; other site
557598007956	cofactor binding site; other site
557598007957	Tim44-like domain; Region: Tim44; cl09208
557598007958	Integral membrane protein TerC family; Region: TerC; cl10468
557598007959	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
557598007960	Transporter associated domain; Region: CorC_HlyC; cl08393
557598007961	outer membrane lipoprotein; Provisional; Region: PRK11023
557598007962	outer membrane lipoprotein; Provisional; Region: PRK11023
557598007963	BON domain; Region: BON; cl02771
557598007964	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
557598007965	dimer interface [polypeptide binding]; other site
557598007966	active site
557598007967	Restriction endonuclease; Region: Mrr_cat; cl00516
557598007968	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
557598007969	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
557598007970	Predicted methyltransferases [General function prediction only]; Region: COG0313
557598007971	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
557598007972	Cache domain; Region: Cache_1; pfam02743
557598007973	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
557598007974	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598007975	dimerization interface [polypeptide binding]; other site
557598007976	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598007977	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598007978	dimer interface [polypeptide binding]; other site
557598007979	putative CheW interface [polypeptide binding]; other site
557598007980	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
557598007981	Helix-turn-helix domains; Region: HTH; cl00088
557598007982	The C-terminal substrate domain of LysR-type transcriptional regulator AmpR that involved in control of the expression of beta-lactamase gene ampC, contains the type 2 periplasmic binding fold; Region: PBP2_AmpR; cd08488
557598007983	putative dimerization interface [polypeptide binding]; other site
557598007984	putative substrate binding pocket [chemical binding]; other site
557598007985	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598007986	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
557598007987	active site
557598007988	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
557598007989	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
557598007990	putative homodimer interface [polypeptide binding]; other site
557598007991	putative homotetramer interface [polypeptide binding]; other site
557598007992	putative allosteric switch controlling residues; other site
557598007993	putative metal binding site [ion binding]; other site
557598007994	putative homodimer-homodimer interface [polypeptide binding]; other site
557598007995	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
557598007996	metal-binding site [ion binding]
557598007997	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
557598007998	metal-binding site [ion binding]
557598007999	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
557598008000	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
557598008001	metal-binding site [ion binding]
557598008002	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
557598008003	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
557598008004	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
557598008005	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
557598008006	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
557598008007	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
557598008008	inhibitor-cofactor binding pocket; inhibition site
557598008009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
557598008010	catalytic residue [active]
557598008011	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
557598008012	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598008013	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
557598008014	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598008015	nucleotide binding region [chemical binding]; other site
557598008016	ATP-binding site [chemical binding]; other site
557598008017	SEC-C motif; Region: SEC-C; pfam02810
557598008018	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
557598008019	FeoA domain; Region: FeoA; cl00838
557598008020	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
557598008021	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
557598008022	G1 box; other site
557598008023	GTP/Mg2+ binding site [chemical binding]; other site
557598008024	Switch I region; other site
557598008025	G2 box; other site
557598008026	G3 box; other site
557598008027	Switch II region; other site
557598008028	G4 box; other site
557598008029	G5 box; other site
557598008030	Nucleoside recognition; Region: Gate; cl00486
557598008031	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
557598008032	Nucleoside recognition; Region: Gate; cl00486
557598008033	Helix-turn-helix domains; Region: HTH; cl00088
557598008034	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
557598008035	trimer interface [polypeptide binding]; other site
557598008036	dimer interface [polypeptide binding]; other site
557598008037	putative active site [active]
557598008038	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
557598008039	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
557598008040	cell division protein FtsZ; Validated; Region: PRK09330
557598008041	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
557598008042	nucleotide binding site [chemical binding]; other site
557598008043	SulA interaction site; other site
557598008044	cell division protein FtsA; Region: ftsA; TIGR01174
557598008045	Cell division protein FtsA; Region: FtsA; cl11496
557598008046	Cell division protein FtsA; Region: FtsA; cl11496
557598008047	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
557598008048	Cell division protein FtsQ; Region: FtsQ; pfam03799
557598008049	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
557598008050	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
557598008051	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598008052	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
557598008053	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
557598008054	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598008055	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598008056	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
557598008057	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
557598008058	active site
557598008059	homodimer interface [polypeptide binding]; other site
557598008060	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
557598008061	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308
557598008062	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598008063	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598008064	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
557598008065	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
557598008066	Mg++ binding site [ion binding]; other site
557598008067	putative catalytic motif [active]
557598008068	putative substrate binding site [chemical binding]; other site
557598008069	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
557598008070	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
557598008071	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598008072	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598008073	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
557598008074	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
557598008075	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
557598008076	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
557598008077	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
557598008078	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
557598008079	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598008080	Septum formation initiator; Region: DivIC; cl11433
557598008081	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
557598008082	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598008083	MraZ protein; Region: MraZ; pfam02381
557598008084	cell division protein MraZ; Reviewed; Region: PRK00326
557598008085	MraZ protein; Region: MraZ; pfam02381
557598008086	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
557598008087	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
557598008088	GatB domain; Region: GatB_Yqey; cl11497
557598008089	Amidase; Region: Amidase; cl11426
557598008090	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
557598008091	rod shape-determining protein MreB; Provisional; Region: PRK13927
557598008092	Cell division protein FtsA; Region: FtsA; cl11496
557598008093	rod shape-determining protein MreC; Provisional; Region: PRK13922
557598008094	rod shape-determining protein MreC; Region: MreC; pfam04085
557598008095	rod shape-determining protein MreD; Region: MreD; cl01087
557598008096	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
557598008097	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
557598008098	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
557598008099	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
557598008100	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
557598008101	EamA-like transporter family; Region: EamA; cl01037
557598008102	EamA-like transporter family; Region: EamA; cl01037
557598008103	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
557598008104	EamA-like transporter family; Region: EamA; cl01037
557598008105	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
557598008106	Amidinotransferase; Region: Amidinotransf; cl12043
557598008107	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
557598008108	ATP binding site [chemical binding]; other site
557598008109	active site
557598008110	substrate binding site [chemical binding]; other site
557598008111	LabA_like proteins; Region: LabA_like; cd06167
557598008112	putative metal binding site [ion binding]; other site
557598008113	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
557598008114	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598008115	AIR carboxylase; Region: AIRC; cl00310
557598008116	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
557598008117	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
557598008118	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
557598008119	substrate binding site [chemical binding]; other site
557598008120	ATP binding site [chemical binding]; other site
557598008121	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
557598008122	Glutamate-cysteine ligase; Region: GshA; pfam08886
557598008123	Dihaem cytochrome c; Region: DHC; pfam09626
557598008124	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
557598008125	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
557598008126	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
557598008127	Rubredoxin [Energy production and conversion]; Region: COG1773
557598008128	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
557598008129	iron binding site [ion binding]; other site
557598008130	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
557598008131	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
557598008132	glutathione synthetase; Provisional; Region: PRK05246
557598008133	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
557598008134	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598008135	ApbE family; Region: ApbE; cl00643
557598008136	Predicted GTPase [General function prediction only]; Region: COG0218
557598008137	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
557598008138	G1 box; other site
557598008139	GTP/Mg2+ binding site [chemical binding]; other site
557598008140	Switch I region; other site
557598008141	G2 box; other site
557598008142	G3 box; other site
557598008143	Switch II region; other site
557598008144	G4 box; other site
557598008145	G5 box; other site
557598008146	Cytochrome c; Region: Cytochrom_C; cl11414
557598008147	Cytochrome c; Region: Cytochrom_C; cl11414
557598008148	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
557598008149	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
557598008150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598008151	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
557598008152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
557598008153	glycerol kinase; Provisional; Region: glpK; PRK00047
557598008154	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
557598008155	N- and C-terminal domain interface [polypeptide binding]; other site
557598008156	active site
557598008157	MgATP binding site [chemical binding]; other site
557598008158	catalytic site [active]
557598008159	metal binding site [ion binding]; metal-binding site
557598008160	glycerol binding site [chemical binding]; other site
557598008161	homotetramer interface [polypeptide binding]; other site
557598008162	homodimer interface [polypeptide binding]; other site
557598008163	FBP binding site [chemical binding]; other site
557598008164	protein IIAGlc interface [polypeptide binding]; other site
557598008165	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
557598008166	Helix-turn-helix domains; Region: HTH; cl00088
557598008167	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
557598008168	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
557598008169	Ligand Binding Site [chemical binding]; other site
557598008170	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
557598008171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598008172	S-adenosylmethionine binding site [chemical binding]; other site
557598008173	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
557598008174	Protein of unknown function (DUF454); Region: DUF454; cl01063
557598008175	peptide chain release factor 1; Validated; Region: prfA; PRK00591
557598008176	RF-1 domain; Region: RF-1; cl02875
557598008177	RF-1 domain; Region: RF-1; cl02875
557598008178	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
557598008179	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
557598008180	tRNA; other site
557598008181	putative tRNA binding site [nucleotide binding]; other site
557598008182	putative NADP binding site [chemical binding]; other site
557598008183	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
557598008184	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
557598008185	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
557598008186	FAD binding domain; Region: FAD_binding_4; pfam01565
557598008187	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
557598008188	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
557598008189	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
557598008190	Cysteine-rich domain; Region: CCG; pfam02754
557598008191	Cysteine-rich domain; Region: CCG; pfam02754
557598008192	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
557598008193	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
557598008194	active site
557598008195	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
557598008196	RuvA N terminal domain; Region: RuvA_N; pfam01330
557598008197	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
557598008198	UbiA prenyltransferase family; Region: UbiA; cl00337
557598008199	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
557598008200	nucleophile elbow; other site
557598008201	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
557598008202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598008203	S-adenosylmethionine binding site [chemical binding]; other site
557598008204	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
557598008205	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
557598008206	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
557598008207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
557598008208	S-adenosylmethionine binding site [chemical binding]; other site
557598008209	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
557598008210	active site
557598008211	intersubunit interface [polypeptide binding]; other site
557598008212	catalytic residue [active]
557598008213	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
557598008214	Cache domain; Region: Cache_2; cl07034
557598008215	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598008216	dimer interface [polypeptide binding]; other site
557598008217	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
557598008218	putative CheW interface [polypeptide binding]; other site
557598008219	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
557598008220	EamA-like transporter family; Region: EamA; cl01037
557598008221	EamA-like transporter family; Region: EamA; cl01037
557598008222	argininosuccinate lyase; Provisional; Region: PRK00855
557598008223	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
557598008224	active sites [active]
557598008225	tetramer interface [polypeptide binding]; other site
557598008226	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
557598008227	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598008228	dimerization interface [polypeptide binding]; other site
557598008229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598008230	metal binding site [ion binding]; metal-binding site
557598008231	active site
557598008232	I-site; other site
557598008233	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598008234	Predicted deacylase [General function prediction only]; Region: COG3608
557598008235	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
557598008236	active site
557598008237	Zn binding site [ion binding]; other site
557598008238	CNP1-like family; Region: CNP1; pfam08750
557598008239	NRDE protein; Region: NRDE; cl01315
557598008240	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
557598008241	CPxP  motif; other site
557598008242	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
557598008243	active site
557598008244	substrate binding pocket [chemical binding]; other site
557598008245	dimer interface [polypeptide binding]; other site
557598008246	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
557598008247	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
557598008248	ATP binding site [chemical binding]; other site
557598008249	Mg++ binding site [ion binding]; other site
557598008250	motif III; other site
557598008251	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
557598008252	nucleotide binding region [chemical binding]; other site
557598008253	ATP-binding site [chemical binding]; other site
557598008254	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
557598008255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
557598008256	putative substrate translocation pore; other site
557598008257	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
557598008258	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598008259	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
557598008260	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
557598008261	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
557598008262	GAF domain; Region: GAF; cl15785
557598008263	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
557598008264	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
557598008265	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
557598008266	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
557598008267	domain interfaces; other site
557598008268	active site
557598008269	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
557598008270	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
557598008271	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
557598008272	Helix-turn-helix domains; Region: HTH; cl00088
557598008273	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
557598008274	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
557598008275	AzlC protein; Region: AzlC; cl00570
557598008276	DNA topoisomerase I; Validated; Region: PRK06599
557598008277	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
557598008278	active site
557598008279	interdomain interaction site; other site
557598008280	putative metal-binding site [ion binding]; other site
557598008281	nucleotide binding site [chemical binding]; other site
557598008282	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
557598008283	domain I; other site
557598008284	DNA binding groove [nucleotide binding]
557598008285	phosphate binding site [ion binding]; other site
557598008286	domain II; other site
557598008287	domain III; other site
557598008288	nucleotide binding site [chemical binding]; other site
557598008289	catalytic site [active]
557598008290	domain IV; other site
557598008291	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
557598008292	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
557598008293	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
557598008294	Protein of unknown function (DUF494); Region: DUF494; cl01103
557598008295	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
557598008296	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
557598008297	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
557598008298	active site
557598008299	catalytic residues [active]
557598008300	metal binding site [ion binding]; metal-binding site
557598008301	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
557598008302	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
557598008303	putative active site [active]
557598008304	putative cosubstrate binding site; other site
557598008305	substrate binding site [chemical binding]; other site
557598008306	catalytic site [active]
557598008307	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
557598008308	substrate binding site [chemical binding]; other site
557598008309	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
557598008310	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
557598008311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
557598008312	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
557598008313	active site
557598008314	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
557598008315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598008316	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
557598008317	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
557598008318	putative ATP binding site [chemical binding]; other site
557598008319	putative substrate interface [chemical binding]; other site
557598008320	Domain of unknown function DUF302; Region: DUF302; cl01364
557598008321	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
557598008322	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
557598008323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598008324	dimer interface [polypeptide binding]; other site
557598008325	conserved gate region; other site
557598008326	putative PBP binding loops; other site
557598008327	ABC-ATPase subunit interface; other site
557598008328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
557598008329	dimer interface [polypeptide binding]; other site
557598008330	conserved gate region; other site
557598008331	putative PBP binding loops; other site
557598008332	ABC-ATPase subunit interface; other site
557598008333	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
557598008334	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
557598008335	Walker A/P-loop; other site
557598008336	ATP binding site [chemical binding]; other site
557598008337	Q-loop/lid; other site
557598008338	ABC transporter signature motif; other site
557598008339	Walker B; other site
557598008340	D-loop; other site
557598008341	H-loop/switch region; other site
557598008342	TOBE-like domain; Region: TOBE_3; pfam12857
557598008343	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
557598008344	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
557598008345	dimer interface [polypeptide binding]; other site
557598008346	putative CheW interface [polypeptide binding]; other site
557598008347	Endonuclease I; Region: Endonuclease_1; cl01003
557598008348	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
557598008349	nucleotide binding site/active site [active]
557598008350	HIT family signature motif; other site
557598008351	catalytic residue [active]
557598008352	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
557598008353	Domain of unknown function DUF21; Region: DUF21; pfam01595
557598008354	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
557598008355	Transporter associated domain; Region: CorC_HlyC; cl08393
557598008356	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
557598008357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598008358	active site
557598008359	phosphorylation site [posttranslational modification]
557598008360	intermolecular recognition site; other site
557598008361	dimerization interface [polypeptide binding]; other site
557598008362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
557598008363	active site
557598008364	phosphorylation site [posttranslational modification]
557598008365	intermolecular recognition site; other site
557598008366	dimerization interface [polypeptide binding]; other site
557598008367	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
557598008368	Tetratricopeptide repeat; Region: TPR_6; pfam13174
557598008369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
557598008370	ligand binding site [chemical binding]; other site
557598008371	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
557598008372	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
557598008373	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
557598008374	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
557598008375	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
557598008376	Gram-negative bacterial tonB protein; Region: TonB; cl10048
557598008377	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
557598008378	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
557598008379	catalytic residues [active]
557598008380	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
557598008381	active site
557598008382	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
557598008383	Gram-negative bacterial tonB protein; Region: TonB; cl10048
557598008384	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
557598008385	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598008386	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
557598008387	putative active site [active]
557598008388	heme pocket [chemical binding]; other site
557598008389	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
557598008390	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598008391	metal binding site [ion binding]; metal-binding site
557598008392	active site
557598008393	I-site; other site
557598008394	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
557598008395	Ferritin-like domain; Region: Ferritin; pfam00210
557598008396	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
557598008397	dimerization interface [polypeptide binding]; other site
557598008398	DPS ferroxidase diiron center [ion binding]; other site
557598008399	ion pore; other site
557598008400	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
557598008401	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
557598008402	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
557598008403	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
557598008404	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
557598008405	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
557598008406	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
557598008407	DsbD alpha interface [polypeptide binding]; other site
557598008408	catalytic residues [active]
557598008409	Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566
557598008410	Predicted acetyltransferase [General function prediction only]; Region: COG3153
557598008411	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
557598008412	Coenzyme A binding pocket [chemical binding]; other site
557598008413	prolyl-tRNA synthetase; Provisional; Region: PRK09194
557598008414	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
557598008415	dimer interface [polypeptide binding]; other site
557598008416	motif 1; other site
557598008417	active site
557598008418	motif 2; other site
557598008419	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
557598008420	putative deacylase active site [active]
557598008421	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
557598008422	active site
557598008423	motif 3; other site
557598008424	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
557598008425	anticodon binding site; other site
557598008426	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
557598008427	active site
557598008428	putative DNA-binding cleft [nucleotide binding]; other site
557598008429	dimer interface [polypeptide binding]; other site
557598008430	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
557598008431	Substrate binding site; other site
557598008432	metal-binding site
557598008433	Phosphotransferase enzyme family; Region: APH; pfam01636
557598008434	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
557598008435	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
557598008436	Organic solvent tolerance protein; Region: OstA_C; pfam04453
557598008437	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
557598008438	SurA N-terminal domain; Region: SurA_N_3; cl07813
557598008439	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598008440	PPIC-type PPIASE domain; Region: Rotamase; cl08278
557598008441	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
557598008442	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
557598008443	RNA binding surface [nucleotide binding]; other site
557598008444	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
557598008445	active site
557598008446	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
557598008447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
557598008448	dimerization interface [polypeptide binding]; other site
557598008449	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
557598008450	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
557598008451	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
557598008452	metal binding site [ion binding]; metal-binding site
557598008453	active site
557598008454	I-site; other site
557598008455	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
557598008456	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
557598008457	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
557598008458	putative catalytic cysteine [active]
557598008459	Protein of unknown function (DUF3422); Region: DUF3422; cl02073
557598008460	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
557598008461	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
557598008462	FMN binding site [chemical binding]; other site
557598008463	active site
557598008464	catalytic residues [active]
557598008465	substrate binding site [chemical binding]; other site
557598008466	Helix-turn-helix domains; Region: HTH; cl00088
557598008467	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
557598008468	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
557598008469	purine monophosphate binding site [chemical binding]; other site
557598008470	dimer interface [polypeptide binding]; other site
557598008471	putative catalytic residues [active]
557598008472	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
557598008473	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
557598008474	Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181
557598008475	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
557598008476	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
557598008477	ATP-grasp domain; Region: ATP-grasp_4; cl03087
557598008478	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
557598008479	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
557598008480	dimer interface [polypeptide binding]; other site
557598008481	FMN binding site [chemical binding]; other site
557598008482	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
557598008483	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
557598008484	active site
557598008485	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
557598008486	putative active site [active]
557598008487	putative catalytic site [active]
557598008488	putative DNA binding site [nucleotide binding]; other site
557598008489	putative phosphate binding site [ion binding]; other site
557598008490	metal binding site A [ion binding]; metal-binding site
557598008491	putative AP binding site [nucleotide binding]; other site
557598008492	putative metal binding site B [ion binding]; other site
557598008493	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
557598008494	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
557598008495	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
557598008496	Cell division protein ZapA; Region: ZapA; cl01146
557598008497	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
557598008498	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
557598008499	cobalamin binding residues [chemical binding]; other site
557598008500	putative BtuC binding residues; other site
557598008501	dimer interface [polypeptide binding]; other site
557598008502	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
557598008503	homotrimer interface [polypeptide binding]; other site
557598008504	Walker A motif; other site
557598008505	GTP binding site [chemical binding]; other site
557598008506	Walker B motif; other site
557598008507	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
557598008508	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
557598008509	N-terminal plug; other site
557598008510	ligand-binding site [chemical binding]; other site
557598008511	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
557598008512	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
557598008513	putative dimer interface [polypeptide binding]; other site
557598008514	active site pocket [active]
557598008515	putative cataytic base [active]
557598008516	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
557598008517	catalytic core [active]
557598008518	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
557598008519	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
557598008520	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
557598008521	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
557598008522	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
557598008523	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
557598008524	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
557598008525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
557598008526	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
557598008527	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
557598008528	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
557598008529	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
557598008530	trmE is a tRNA modification GTPase; Region: trmE; cd04164
557598008531	G1 box; other site
557598008532	GTP/Mg2+ binding site [chemical binding]; other site
557598008533	Switch I region; other site
557598008534	G2 box; other site
557598008535	Switch II region; other site
557598008536	G3 box; other site
557598008537	G4 box; other site
557598008538	G5 box; other site
557598008539	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
557598008540	membrane protein insertase; Provisional; Region: PRK01318
557598008541	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
557598008542	Haemolytic domain; Region: Haemolytic; cl00506
557598008543	Ribonuclease P; Region: Ribonuclease_P; cl00457
557598008544	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
557598008545	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
557598008546	DnaA N-terminal domain; Region: DnaA_N; pfam11638
557598008547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
557598008548	Walker A motif; other site
557598008549	ATP binding site [chemical binding]; other site
557598008550	Walker B motif; other site
557598008551	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
557598008552	arginine finger; other site
557598008553	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
557598008554	DnaA box-binding interface [nucleotide binding]; other site
557598008555	DNA polymerase III subunit beta; Validated; Region: PRK05643
557598008556	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
557598008557	putative DNA binding surface [nucleotide binding]; other site
557598008558	dimer interface [polypeptide binding]; other site
557598008559	beta-clamp/translesion DNA polymerase binding surface; other site
557598008560	beta-clamp/clamp loader binding surface; other site
557598008561	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
557598008562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
557598008563	Mg2+ binding site [ion binding]; other site
557598008564	G-X-G motif; other site
557598008565	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
557598008566	anchoring element; other site
557598008567	dimer interface [polypeptide binding]; other site
557598008568	ATP binding site [chemical binding]; other site
557598008569	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
557598008570	active site
557598008571	putative metal-binding site [ion binding]; other site
557598008572	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
557598008573	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
557598008574	additional DNA contacts [nucleotide binding]; other site
557598008575	mismatch recognition site; other site
557598008576	active site
557598008577	zinc binding site [ion binding]; other site
557598008578	DNA intercalation site [nucleotide binding]; other site
557598008579	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
557598008580	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
557598008581	cofactor binding site; other site
557598008582	DNA binding site [nucleotide binding]
557598008583	substrate interaction site [chemical binding]; other site
557598008584	LysR family transcriptional regulator; Provisional; Region: PRK14997
557598008585	Helix-turn-helix domains; Region: HTH; cl00088
557598008586	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
557598008587	putative effector binding pocket; other site
557598008588	putative dimerization interface [polypeptide binding]; other site
557598008589	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
557598008590	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
557598008591	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
557598008592	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
557598008593	dinuclear metal binding motif [ion binding]; other site
557598008594	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
557598008595	active site
557598008596	HIGH motif; other site
557598008597	nucleotide binding site [chemical binding]; other site
557598008598	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
557598008599	Helix-turn-helix domains; Region: HTH; cl00088
557598008600	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
557598008601	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
557598008602	Type III pantothenate kinase; Region: Pan_kinase; cl09130
557598008603	Sporulation related domain; Region: SPOR; cl10051
557598008604	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609