-- dump date 20120504_151437 -- class Genbank::misc_feature -- table misc_feature_note -- id note 661367000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 661367000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 661367000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000004 Walker A motif; other site 661367000005 ATP binding site [chemical binding]; other site 661367000006 Walker B motif; other site 661367000007 arginine finger; other site 661367000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 661367000009 DnaA box-binding interface [nucleotide binding]; other site 661367000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 661367000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 661367000012 putative DNA binding surface [nucleotide binding]; other site 661367000013 dimer interface [polypeptide binding]; other site 661367000014 beta-clamp/clamp loader binding surface; other site 661367000015 beta-clamp/translesion DNA polymerase binding surface; other site 661367000016 recombination protein F; Reviewed; Region: recF; PRK00064 661367000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000018 Walker A/P-loop; other site 661367000019 ATP binding site [chemical binding]; other site 661367000020 Q-loop/lid; other site 661367000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000022 ABC transporter signature motif; other site 661367000023 Walker B; other site 661367000024 D-loop; other site 661367000025 H-loop/switch region; other site 661367000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 661367000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367000028 Mg2+ binding site [ion binding]; other site 661367000029 G-X-G motif; other site 661367000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 661367000031 anchoring element; other site 661367000032 dimer interface [polypeptide binding]; other site 661367000033 ATP binding site [chemical binding]; other site 661367000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 661367000035 active site 661367000036 putative metal-binding site [ion binding]; other site 661367000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 661367000038 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 661367000039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000040 active site 661367000041 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 661367000042 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 661367000043 agmatine deiminase; Region: agmatine_aguA; TIGR03380 661367000044 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 661367000045 arginine decarboxylase; Provisional; Region: PRK05354 661367000046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 661367000047 dimer interface [polypeptide binding]; other site 661367000048 active site 661367000049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367000050 catalytic residues [active] 661367000051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 661367000052 N-carbamolyputrescine amidase; Region: PLN02747 661367000053 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 661367000054 putative active site; other site 661367000055 catalytic triad [active] 661367000056 putative dimer interface [polypeptide binding]; other site 661367000057 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 661367000058 Sm1 motif; other site 661367000059 D3 - B interaction site; other site 661367000060 D1 - D2 interaction site; other site 661367000061 Hfq - Hfq interaction site; other site 661367000062 RNA binding pocket [nucleotide binding]; other site 661367000063 Sm2 motif; other site 661367000064 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 661367000065 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 661367000066 HflX GTPase family; Region: HflX; cd01878 661367000067 G1 box; other site 661367000068 GTP/Mg2+ binding site [chemical binding]; other site 661367000069 Switch I region; other site 661367000070 G2 box; other site 661367000071 G3 box; other site 661367000072 Switch II region; other site 661367000073 G4 box; other site 661367000074 G5 box; other site 661367000075 Phosphotransferase enzyme family; Region: APH; pfam01636 661367000076 thymidine kinase; Provisional; Region: PRK04296 661367000077 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 661367000078 catalytic residues [active] 661367000079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367000080 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 661367000081 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367000082 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367000083 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367000084 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367000085 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 661367000086 Transposase domain (DUF772); Region: DUF772; cl15789 661367000087 Transposase domain (DUF772); Region: DUF772; cl15789 661367000088 Transposase domain (DUF772); Region: DUF772; cl15789 661367000089 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367000090 Phosphotransferase enzyme family; Region: APH; pfam01636 661367000091 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 661367000092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367000093 ATP binding site [chemical binding]; other site 661367000094 putative Mg++ binding site [ion binding]; other site 661367000095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367000096 nucleotide binding region [chemical binding]; other site 661367000097 ATP-binding site [chemical binding]; other site 661367000098 Helicase associated domain (HA2); Region: HA2; cl04503 661367000099 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 661367000100 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367000101 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000102 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000103 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000104 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000105 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367000106 active site 661367000107 ATP binding site [chemical binding]; other site 661367000108 substrate binding site [chemical binding]; other site 661367000109 activation loop (A-loop); other site 661367000110 Pirin-related protein [General function prediction only]; Region: COG1741 661367000111 Cupin domain; Region: Cupin_2; cl09118 661367000112 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 661367000113 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 661367000114 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 661367000115 Sporulation related domain; Region: SPOR; cl10051 661367000116 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367000117 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 661367000118 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 661367000119 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 661367000120 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 661367000121 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 661367000122 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367000123 active site 661367000124 Zn binding site [ion binding]; other site 661367000125 Protein of unknown function (DUF615); Region: DUF615; cl01147 661367000126 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 661367000127 THUMP domain; Region: THUMP; cl12076 661367000128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367000130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000131 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 661367000132 active site 661367000133 Protein of unknown function (DUF962); Region: DUF962; cl01879 661367000134 Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181 661367000135 amino acid transporter; Region: 2A0306; TIGR00909 661367000136 Spore germination protein; Region: Spore_permease; cl15802 661367000137 Spore germination protein; Region: Spore_permease; cl15802 661367000138 Phosphate transporter family; Region: PHO4; cl00396 661367000139 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 661367000140 diiron binding motif [ion binding]; other site 661367000141 acetylornithine aminotransferase; Provisional; Region: PRK02627 661367000142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367000143 inhibitor-cofactor binding pocket; inhibition site 661367000144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367000145 catalytic residue [active] 661367000146 superoxide dismutase; Provisional; Region: PRK10543 661367000147 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 661367000148 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 661367000149 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 661367000150 putative GSH binding site [chemical binding]; other site 661367000151 catalytic residues [active] 661367000152 peroxidase; Provisional; Region: PRK15000 661367000153 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 661367000154 dimer interface [polypeptide binding]; other site 661367000155 decamer (pentamer of dimers) interface [polypeptide binding]; other site 661367000156 catalytic triad [active] 661367000157 peroxidatic and resolving cysteines [active] 661367000158 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 661367000159 active site 661367000160 catalytic site [active] 661367000161 substrate binding site [chemical binding]; other site 661367000162 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 661367000163 active site 661367000164 substrate binding pocket [chemical binding]; other site 661367000165 dimer interface [polypeptide binding]; other site 661367000166 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000167 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000168 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367000169 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 661367000170 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 661367000171 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 661367000172 dimer interface [polypeptide binding]; other site 661367000173 active site residues [active] 661367000174 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 661367000175 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 661367000176 JmjC domain, hydroxylase; Region: JmjC; cl15814 661367000177 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 661367000178 trimer interface [polypeptide binding]; other site 661367000179 active site 661367000180 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367000181 IHF dimer interface [polypeptide binding]; other site 661367000182 IHF - DNA interface [nucleotide binding]; other site 661367000183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367000184 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 661367000185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 661367000186 dimer interface [polypeptide binding]; other site 661367000187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367000188 catalytic residue [active] 661367000189 fumarate hydratase; Reviewed; Region: fumC; PRK00485 661367000190 Class II fumarases; Region: Fumarase_classII; cd01362 661367000191 active site 661367000192 tetramer interface [polypeptide binding]; other site 661367000193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 661367000194 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 661367000195 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 661367000196 catalytic residues [active] 661367000197 transcription termination factor Rho; Provisional; Region: rho; PRK09376 661367000198 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 661367000199 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 661367000200 RNA binding site [nucleotide binding]; other site 661367000201 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 661367000202 multimer interface [polypeptide binding]; other site 661367000203 Walker A motif; other site 661367000204 ATP binding site [chemical binding]; other site 661367000205 Walker B motif; other site 661367000206 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 661367000207 FMN reductase; Validated; Region: fre; PRK08051 661367000208 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 661367000209 FAD binding pocket [chemical binding]; other site 661367000210 FAD binding motif [chemical binding]; other site 661367000211 phosphate binding motif [ion binding]; other site 661367000212 beta-alpha-beta structure motif; other site 661367000213 NAD binding pocket [chemical binding]; other site 661367000214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000215 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000216 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 661367000217 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 661367000218 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 661367000219 putative diguanylate cyclase; Provisional; Region: PRK09776 661367000220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367000221 putative active site [active] 661367000222 heme pocket [chemical binding]; other site 661367000223 GAF domain; Region: GAF; cl15785 661367000224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367000225 metal binding site [ion binding]; metal-binding site 661367000226 active site 661367000227 I-site; other site 661367000228 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 661367000229 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 661367000230 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367000231 DNA-binding site [nucleotide binding]; DNA binding site 661367000232 RNA-binding motif; other site 661367000233 Haemolysin-III related; Region: HlyIII; cl03831 661367000234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 661367000235 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 661367000236 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 661367000237 active site 661367000238 Zn binding site [ion binding]; other site 661367000239 DDE domain; Region: DDE_Tnp_IS240; pfam13610 661367000240 Integrase core domain; Region: rve; cl01316 661367000241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367000242 DNA binding site [nucleotide binding] 661367000243 Int/Topo IB signature motif; other site 661367000244 active site 661367000245 Transposase domain (DUF772); Region: DUF772; cl15789 661367000246 Transposase domain (DUF772); Region: DUF772; cl15789 661367000247 Transposase domain (DUF772); Region: DUF772; cl15789 661367000248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367000249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 661367000250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367000251 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 661367000252 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367000253 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000255 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367000256 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 661367000257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 661367000258 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367000259 Ligand Binding Site [chemical binding]; other site 661367000260 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 661367000261 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 661367000262 putative active site [active] 661367000263 putative metal binding site [ion binding]; other site 661367000264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367000265 active site 661367000266 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 661367000267 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 661367000268 tetramerization interface [polypeptide binding]; other site 661367000269 active site 661367000270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000271 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 661367000272 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 661367000273 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 661367000274 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 661367000275 active site 661367000276 metal binding site [ion binding]; metal-binding site 661367000277 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367000278 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367000279 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367000280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 661367000281 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 661367000282 Walker A/P-loop; other site 661367000283 ATP binding site [chemical binding]; other site 661367000284 Q-loop/lid; other site 661367000285 ABC transporter signature motif; other site 661367000286 Walker B; other site 661367000287 D-loop; other site 661367000288 H-loop/switch region; other site 661367000289 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367000290 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 661367000291 FtsX-like permease family; Region: FtsX; cl15850 661367000292 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 661367000293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367000295 Helix-turn-helix domains; Region: HTH; cl00088 661367000296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367000297 dimerization interface [polypeptide binding]; other site 661367000298 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 661367000299 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 661367000300 Transglycosylase SLT domain; Region: SLT_2; pfam13406 661367000301 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 661367000302 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 661367000303 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 661367000304 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 661367000305 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 661367000306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367000307 Coenzyme A binding pocket [chemical binding]; other site 661367000308 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 661367000309 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 661367000310 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367000311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 661367000312 active site 661367000313 ATP binding site [chemical binding]; other site 661367000314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 661367000315 SCP-2 sterol transfer family; Region: SCP2; cl01225 661367000316 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 661367000317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000318 S-adenosylmethionine binding site [chemical binding]; other site 661367000319 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 661367000320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367000321 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 661367000322 LysE type translocator; Region: LysE; cl00565 661367000323 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 661367000324 Cytochrome c; Region: Cytochrom_C; cl11414 661367000325 Cytochrome c; Region: Cytochrom_C; cl11414 661367000326 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 661367000327 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 661367000328 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367000329 Cytochrome c; Region: Cytochrom_C; cl11414 661367000330 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 661367000331 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 661367000332 Subunit I/III interface [polypeptide binding]; other site 661367000333 D-pathway; other site 661367000334 Subunit I/VIIc interface [polypeptide binding]; other site 661367000335 Subunit I/IV interface [polypeptide binding]; other site 661367000336 Subunit I/II interface [polypeptide binding]; other site 661367000337 Low-spin heme (heme a) binding site [chemical binding]; other site 661367000338 Subunit I/VIIa interface [polypeptide binding]; other site 661367000339 Subunit I/VIa interface [polypeptide binding]; other site 661367000340 Dimer interface; other site 661367000341 Putative water exit pathway; other site 661367000342 Binuclear center (heme a3/CuB) [ion binding]; other site 661367000343 K-pathway; other site 661367000344 Subunit I/Vb interface [polypeptide binding]; other site 661367000345 Putative proton exit pathway; other site 661367000346 Subunit I/VIb interface; other site 661367000347 Subunit I/VIc interface [polypeptide binding]; other site 661367000348 Electron transfer pathway; other site 661367000349 Subunit I/VIIIb interface [polypeptide binding]; other site 661367000350 Subunit I/VIIb interface [polypeptide binding]; other site 661367000351 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 661367000352 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 661367000353 Subunit III/VIIa interface [polypeptide binding]; other site 661367000354 Phospholipid binding site [chemical binding]; other site 661367000355 Subunit I/III interface [polypeptide binding]; other site 661367000356 Subunit III/VIb interface [polypeptide binding]; other site 661367000357 Subunit III/VIa interface; other site 661367000358 Subunit III/Vb interface [polypeptide binding]; other site 661367000359 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367000360 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 661367000361 active site 661367000362 catalytic residues [active] 661367000363 ParB-like partition proteins; Region: parB_part; TIGR00180 661367000364 ParB-like nuclease domain; Region: ParBc; cl02129 661367000365 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 661367000366 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367000367 P-loop; other site 661367000368 Magnesium ion binding site [ion binding]; other site 661367000369 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367000370 Magnesium ion binding site [ion binding]; other site 661367000371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367000372 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 661367000373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000375 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 661367000376 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367000377 Oxygen tolerance; Region: BatD; pfam13584 661367000378 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 661367000379 TPR repeat; Region: TPR_11; pfam13414 661367000380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367000381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 661367000382 metal ion-dependent adhesion site (MIDAS); other site 661367000383 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 661367000384 metal ion-dependent adhesion site (MIDAS); other site 661367000385 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 661367000386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 661367000387 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 661367000388 metal ion-dependent adhesion site (MIDAS); other site 661367000389 MoxR-like ATPases [General function prediction only]; Region: COG0714 661367000390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000391 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 661367000392 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 661367000393 FMN binding site [chemical binding]; other site 661367000394 active site 661367000395 catalytic residues [active] 661367000396 substrate binding site [chemical binding]; other site 661367000397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367000398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000399 pteridine reductase; Provisional; Region: PRK09135 661367000400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000401 NAD(P) binding site [chemical binding]; other site 661367000402 active site 661367000403 Uncharacterized conserved protein [Function unknown]; Region: COG1565 661367000404 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 661367000405 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 661367000406 primosome assembly protein PriA; Validated; Region: PRK05580 661367000407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367000408 ATP binding site [chemical binding]; other site 661367000409 putative Mg++ binding site [ion binding]; other site 661367000410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000411 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 661367000412 active site 661367000413 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367000414 CHASE2 domain; Region: CHASE2; cl01732 661367000415 cyclase homology domain; Region: CHD; cd07302 661367000416 nucleotidyl binding site; other site 661367000417 metal binding site [ion binding]; metal-binding site 661367000418 dimer interface [polypeptide binding]; other site 661367000419 FecR protein; Region: FecR; pfam04773 661367000420 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 661367000421 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 661367000422 dimerization interface [polypeptide binding]; other site 661367000423 active site 661367000424 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 661367000425 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 661367000426 GAF domain; Region: GAF; cl15785 661367000427 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 661367000428 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 661367000429 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 661367000430 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 661367000431 putative active site [active] 661367000432 Ap4A binding site [chemical binding]; other site 661367000433 nudix motif; other site 661367000434 putative metal binding site [ion binding]; other site 661367000435 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 661367000436 active site 661367000437 homodimer interface [polypeptide binding]; other site 661367000438 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 661367000439 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 661367000440 Substrate binding site; other site 661367000441 Mg++ binding site; other site 661367000442 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 661367000443 active site 661367000444 substrate binding site [chemical binding]; other site 661367000445 CoA binding site [chemical binding]; other site 661367000446 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 661367000447 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 661367000448 endonuclease III; Provisional; Region: PRK10702 661367000449 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367000450 minor groove reading motif; other site 661367000451 helix-hairpin-helix signature motif; other site 661367000452 substrate binding pocket [chemical binding]; other site 661367000453 active site 661367000454 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 661367000455 electron transport complex protein RnfB; Provisional; Region: PRK05113 661367000456 Putative Fe-S cluster; Region: FeS; pfam04060 661367000457 4Fe-4S binding domain; Region: Fer4; cl02805 661367000458 electron transport complex protein RnfC; Provisional; Region: PRK05035 661367000459 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 661367000460 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 661367000461 active site 661367000462 HIGH motif; other site 661367000463 KMSKS motif; other site 661367000464 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 661367000465 tRNA binding surface [nucleotide binding]; other site 661367000466 anticodon binding site; other site 661367000467 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 661367000468 Ligand Binding Site [chemical binding]; other site 661367000469 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 661367000470 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 661367000471 Substrate binding site; other site 661367000472 Cupin domain; Region: Cupin_2; cl09118 661367000473 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 661367000474 B1 nucleotide binding pocket [chemical binding]; other site 661367000475 B2 nucleotide binding pocket [chemical binding]; other site 661367000476 CAS motifs; other site 661367000477 active site 661367000478 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 661367000479 Esterase/lipase [General function prediction only]; Region: COG1647 661367000480 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 661367000481 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 661367000482 active site 661367000483 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 661367000484 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 661367000485 putative active site [active] 661367000486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000487 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 661367000488 catalytic triad [active] 661367000489 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 661367000490 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 661367000491 SmpB-tmRNA interface; other site 661367000492 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 661367000493 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 661367000494 active site residue [active] 661367000495 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367000496 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367000497 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367000498 active site 661367000499 oxyanion hole [active] 661367000500 catalytic triad [active] 661367000501 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 661367000502 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 661367000503 glutaminase active site [active] 661367000504 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 661367000505 dimer interface [polypeptide binding]; other site 661367000506 active site 661367000507 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 661367000508 dimer interface [polypeptide binding]; other site 661367000509 active site 661367000510 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 661367000511 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 661367000512 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 661367000513 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 661367000514 RNA binding site [nucleotide binding]; other site 661367000515 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 661367000516 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 661367000517 Lumazine binding domain; Region: Lum_binding; pfam00677 661367000518 Lumazine binding domain; Region: Lum_binding; pfam00677 661367000519 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 661367000520 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 661367000521 putative ion selectivity filter; other site 661367000522 putative pore gating glutamate residue; other site 661367000523 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 661367000524 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 661367000525 active site 661367000526 homodimer interface [polypeptide binding]; other site 661367000527 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 661367000528 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 661367000529 NAD binding site [chemical binding]; other site 661367000530 homotetramer interface [polypeptide binding]; other site 661367000531 homodimer interface [polypeptide binding]; other site 661367000532 substrate binding site [chemical binding]; other site 661367000533 active site 661367000534 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 661367000535 substrate binding site; other site 661367000536 GtrA-like protein; Region: GtrA; cl00971 661367000537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000538 S-adenosylmethionine binding site [chemical binding]; other site 661367000539 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 661367000540 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 661367000541 Ligand binding site; other site 661367000542 Putative Catalytic site; other site 661367000543 DXD motif; other site 661367000544 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 661367000545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000546 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 661367000547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367000548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000549 OpgC protein; Region: OpgC_C; cl00792 661367000550 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367000551 MatE; Region: MatE; cl10513 661367000552 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367000553 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 661367000554 putative active site [active] 661367000555 putative metal binding site [ion binding]; other site 661367000556 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 661367000557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 661367000558 active site 661367000559 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367000560 OpgC protein; Region: OpgC_C; cl00792 661367000561 putative glycosyl transferase; Provisional; Region: PRK10307 661367000562 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 661367000563 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 661367000564 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 661367000565 NADP binding site [chemical binding]; other site 661367000566 active site 661367000567 putative substrate binding site [chemical binding]; other site 661367000568 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 661367000569 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 661367000570 NAD(P) binding site [chemical binding]; other site 661367000571 homodimer interface [polypeptide binding]; other site 661367000572 substrate binding site [chemical binding]; other site 661367000573 active site 661367000574 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 661367000575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367000576 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 661367000577 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 661367000578 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 661367000579 homotetramer interface [polypeptide binding]; other site 661367000580 FMN binding site [chemical binding]; other site 661367000581 homodimer contacts [polypeptide binding]; other site 661367000582 putative active site [active] 661367000583 putative substrate binding site [chemical binding]; other site 661367000584 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 661367000585 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367000586 DNA-binding site [nucleotide binding]; DNA binding site 661367000587 RNA-binding motif; other site 661367000588 putative transporter; Provisional; Region: PRK10504 661367000589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367000590 putative substrate translocation pore; other site 661367000591 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 661367000592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000593 Family description; Region: UvrD_C_2; cl15862 661367000594 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 661367000595 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 661367000596 dimerization interface [polypeptide binding]; other site 661367000597 domain crossover interface; other site 661367000598 redox-dependent activation switch; other site 661367000599 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367000600 Caleosin related protein; Region: Caleosin; pfam05042 661367000601 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 661367000602 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 661367000603 G1 box; other site 661367000604 putative GEF interaction site [polypeptide binding]; other site 661367000605 GTP/Mg2+ binding site [chemical binding]; other site 661367000606 Switch I region; other site 661367000607 G2 box; other site 661367000608 G3 box; other site 661367000609 Switch II region; other site 661367000610 G4 box; other site 661367000611 G5 box; other site 661367000612 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 661367000613 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 661367000614 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 661367000615 recombination and repair protein; Provisional; Region: PRK10869 661367000616 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 661367000617 Walker A/P-loop; other site 661367000618 ATP binding site [chemical binding]; other site 661367000619 Q-loop/lid; other site 661367000620 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 661367000621 ABC transporter signature motif; other site 661367000622 Walker B; other site 661367000623 D-loop; other site 661367000624 H-loop/switch region; other site 661367000625 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 661367000626 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 661367000627 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 661367000628 metal binding site [ion binding]; metal-binding site 661367000629 SpoVR family protein; Provisional; Region: PRK11767 661367000630 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 661367000631 Uncharacterized conserved protein [Function unknown]; Region: COG2718 661367000632 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 661367000633 PrkA family serine protein kinase; Provisional; Region: PRK15455 661367000634 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 661367000635 aminopeptidase N; Provisional; Region: pepN; PRK14015 661367000636 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 661367000637 active site 661367000638 Zn binding site [ion binding]; other site 661367000639 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 661367000640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367000641 ligand binding site [chemical binding]; other site 661367000642 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 661367000643 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 661367000644 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 661367000645 shikimate binding site; other site 661367000646 NAD(P) binding site [chemical binding]; other site 661367000647 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367000648 nucleophile elbow; other site 661367000649 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 661367000650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367000651 putative substrate translocation pore; other site 661367000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367000653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367000654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367000655 substrate binding pocket [chemical binding]; other site 661367000656 membrane-bound complex binding site; other site 661367000657 hinge residues; other site 661367000658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000659 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 661367000660 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367000661 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 661367000662 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 661367000663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367000664 S-adenosylmethionine binding site [chemical binding]; other site 661367000665 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 661367000666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000667 Walker A motif; other site 661367000668 ATP binding site [chemical binding]; other site 661367000669 Walker B motif; other site 661367000670 arginine finger; other site 661367000671 Peptidase family M41; Region: Peptidase_M41; pfam01434 661367000672 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 661367000673 dihydropteroate synthase; Region: DHPS; TIGR01496 661367000674 substrate binding pocket [chemical binding]; other site 661367000675 dimer interface [polypeptide binding]; other site 661367000676 inhibitor binding site; inhibition site 661367000677 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 661367000678 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 661367000679 active site 661367000680 substrate binding site [chemical binding]; other site 661367000681 metal binding site [ion binding]; metal-binding site 661367000682 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 661367000683 substrate binding site [chemical binding]; other site 661367000684 dimer interface [polypeptide binding]; other site 661367000685 catalytic triad [active] 661367000686 Preprotein translocase SecG subunit; Region: SecG; cl09123 661367000687 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 661367000688 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 661367000689 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 661367000690 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 661367000691 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 661367000692 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 661367000693 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 661367000694 putative dimer interface [polypeptide binding]; other site 661367000695 [2Fe-2S] cluster binding site [ion binding]; other site 661367000696 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 661367000697 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 661367000698 SLBB domain; Region: SLBB; pfam10531 661367000699 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 661367000700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 661367000701 NADH dehydrogenase subunit G; Validated; Region: PRK09129 661367000702 catalytic loop [active] 661367000703 iron binding site [ion binding]; other site 661367000704 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 661367000705 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 661367000706 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 661367000707 molybdopterin cofactor binding site; other site 661367000708 NADH dehydrogenase; Region: NADHdh; cl00469 661367000709 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 661367000710 4Fe-4S binding domain; Region: Fer4; cl02805 661367000711 4Fe-4S binding domain; Region: Fer4; cl02805 661367000712 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 661367000713 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 661367000714 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 661367000715 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 661367000716 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 661367000717 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 661367000718 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 661367000719 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 661367000720 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 661367000721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 661367000722 ribosome maturation protein RimP; Reviewed; Region: PRK00092 661367000723 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 661367000724 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 661367000725 Sm1 motif; other site 661367000726 D3 - B interaction site; other site 661367000727 D1 - D2 interaction site; other site 661367000728 Hfq - Hfq interaction site; other site 661367000729 RNA binding pocket [nucleotide binding]; other site 661367000730 Sm2 motif; other site 661367000731 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 661367000732 NusA N-terminal domain; Region: NusA_N; pfam08529 661367000733 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 661367000734 RNA binding site [nucleotide binding]; other site 661367000735 homodimer interface [polypeptide binding]; other site 661367000736 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 661367000737 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 661367000738 G-X-X-G motif; other site 661367000739 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 661367000740 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 661367000741 translation initiation factor IF-2; Validated; Region: infB; PRK05306 661367000742 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 661367000743 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 661367000744 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 661367000745 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 661367000746 G1 box; other site 661367000747 putative GEF interaction site [polypeptide binding]; other site 661367000748 GTP/Mg2+ binding site [chemical binding]; other site 661367000749 Switch I region; other site 661367000750 G2 box; other site 661367000751 G3 box; other site 661367000752 Switch II region; other site 661367000753 G4 box; other site 661367000754 G5 box; other site 661367000755 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 661367000756 Translation-initiation factor 2; Region: IF-2; pfam11987 661367000757 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 661367000758 Ribosome-binding factor A; Region: RBFA; cl00542 661367000759 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 661367000760 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 661367000761 RNA binding site [nucleotide binding]; other site 661367000762 active site 661367000763 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 661367000764 16S/18S rRNA binding site [nucleotide binding]; other site 661367000765 S13e-L30e interaction site [polypeptide binding]; other site 661367000766 25S rRNA binding site [nucleotide binding]; other site 661367000767 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 661367000768 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 661367000769 RNase E interface [polypeptide binding]; other site 661367000770 trimer interface [polypeptide binding]; other site 661367000771 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 661367000772 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 661367000773 RNase E interface [polypeptide binding]; other site 661367000774 trimer interface [polypeptide binding]; other site 661367000775 active site 661367000776 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 661367000777 putative nucleic acid binding region [nucleotide binding]; other site 661367000778 G-X-X-G motif; other site 661367000779 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 661367000780 RNA binding site [nucleotide binding]; other site 661367000781 domain interface; other site 661367000782 GTP cyclohydrolase I; Provisional; Region: PLN03044 661367000783 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 661367000784 homodecamer interface [polypeptide binding]; other site 661367000785 active site 661367000786 putative catalytic site residues [active] 661367000787 zinc binding site [ion binding]; other site 661367000788 GTP-CH-I/GFRP interaction surface; other site 661367000789 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 661367000790 nucleotide binding site/active site [active] 661367000791 HIT family signature motif; other site 661367000792 catalytic residue [active] 661367000793 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 661367000794 dimer interface [polypeptide binding]; other site 661367000795 substrate binding site [chemical binding]; other site 661367000796 metal binding sites [ion binding]; metal-binding site 661367000797 hypothetical protein; Provisional; Region: PRK11573 661367000798 Domain of unknown function DUF21; Region: DUF21; pfam01595 661367000799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367000800 Transporter associated domain; Region: CorC_HlyC; cl08393 661367000801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367000802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367000803 active site 661367000804 dimerization interface [polypeptide binding]; other site 661367000805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367000806 DNA binding site [nucleotide binding] 661367000807 Protein of unknown function, DUF547; Region: DUF547; pfam04784 661367000808 recombination protein RecR; Reviewed; Region: recR; PRK00076 661367000809 RecR protein; Region: RecR; pfam02132 661367000810 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 661367000811 putative active site [active] 661367000812 putative metal-binding site [ion binding]; other site 661367000813 tetramer interface [polypeptide binding]; other site 661367000814 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 661367000815 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 661367000816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367000817 Walker A motif; other site 661367000818 ATP binding site [chemical binding]; other site 661367000819 Walker B motif; other site 661367000820 arginine finger; other site 661367000821 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 661367000822 GTPase RsgA; Reviewed; Region: PRK12288 661367000823 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 661367000824 RNA binding site [nucleotide binding]; other site 661367000825 homodimer interface [polypeptide binding]; other site 661367000826 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 661367000827 GTPase/Zn-binding domain interface [polypeptide binding]; other site 661367000828 GTP/Mg2+ binding site [chemical binding]; other site 661367000829 G4 box; other site 661367000830 G5 box; other site 661367000831 G1 box; other site 661367000832 Switch I region; other site 661367000833 G2 box; other site 661367000834 G3 box; other site 661367000835 Switch II region; other site 661367000836 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 661367000837 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367000838 active site 661367000839 NTP binding site [chemical binding]; other site 661367000840 metal binding triad [ion binding]; metal-binding site 661367000841 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367000842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 661367000843 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 661367000844 putative active site [active] 661367000845 putative substrate binding site [chemical binding]; other site 661367000846 catalytic site [active] 661367000847 dimer interface [polypeptide binding]; other site 661367000848 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 661367000849 Cation efflux family; Region: Cation_efflux; cl00316 661367000850 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 661367000851 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 661367000852 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 661367000853 NAD binding site [chemical binding]; other site 661367000854 homotetramer interface [polypeptide binding]; other site 661367000855 homodimer interface [polypeptide binding]; other site 661367000856 substrate binding site [chemical binding]; other site 661367000857 active site 661367000858 V-type ATP synthase subunit B; Provisional; Region: PRK02118 661367000859 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 661367000860 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 661367000861 Walker A motif homologous position; other site 661367000862 Walker B motif; other site 661367000863 ATP synthase subunit D; Region: ATP-synt_D; cl00613 661367000864 V-type ATP synthase subunit I; Validated; Region: PRK05771 661367000865 V-type ATP synthase subunit K; Provisional; Region: PRK09621 661367000866 Plant ATP synthase F0; Region: YMF19; cl07975 661367000867 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 661367000868 V-type ATP synthase subunit A; Provisional; Region: PRK04192 661367000869 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 661367000870 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 661367000871 Walker A motif/ATP binding site; other site 661367000872 Walker B motif; other site 661367000873 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 661367000874 HemY protein N-terminus; Region: HemY_N; pfam07219 661367000875 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 661367000876 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 661367000877 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 661367000878 active site 661367000879 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 661367000880 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 661367000881 domain interfaces; other site 661367000882 active site 661367000883 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 661367000884 Ras interaction site [polypeptide binding]; other site 661367000885 Cytochrome c; Region: Cytochrom_C; cl11414 661367000886 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 661367000887 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367000888 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 661367000889 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 661367000890 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 661367000891 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 661367000892 substrate binding site [chemical binding]; other site 661367000893 Predicted membrane protein [Function unknown]; Region: COG2860 661367000894 UPF0126 domain; Region: UPF0126; pfam03458 661367000895 UPF0126 domain; Region: UPF0126; pfam03458 661367000896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367000897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 661367000898 Helix-turn-helix domains; Region: HTH; cl00088 661367000899 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367000900 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367000901 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 661367000902 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 661367000903 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 661367000904 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 661367000905 active site 661367000906 dimer interface [polypeptide binding]; other site 661367000907 motif 1; other site 661367000908 motif 2; other site 661367000909 motif 3; other site 661367000910 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 661367000911 anticodon binding site; other site 661367000912 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 661367000913 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 661367000914 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 661367000915 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 661367000916 23S rRNA binding site [nucleotide binding]; other site 661367000917 L21 binding site [polypeptide binding]; other site 661367000918 L13 binding site [polypeptide binding]; other site 661367000919 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 661367000920 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 661367000921 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 661367000922 dimer interface [polypeptide binding]; other site 661367000923 motif 1; other site 661367000924 active site 661367000925 motif 2; other site 661367000926 motif 3; other site 661367000927 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 661367000928 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 661367000929 putative tRNA-binding site [nucleotide binding]; other site 661367000930 B3/4 domain; Region: B3_4; cl11458 661367000931 tRNA synthetase B5 domain; Region: B5; cl08394 661367000932 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 661367000933 dimer interface [polypeptide binding]; other site 661367000934 motif 1; other site 661367000935 motif 3; other site 661367000936 motif 2; other site 661367000937 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 661367000938 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367000939 IHF dimer interface [polypeptide binding]; other site 661367000940 IHF - DNA interface [nucleotide binding]; other site 661367000941 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 661367000942 dimer interface [polypeptide binding]; other site 661367000943 [2Fe-2S] cluster binding site [ion binding]; other site 661367000944 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 661367000945 23S rRNA interface [nucleotide binding]; other site 661367000946 L3 interface [polypeptide binding]; other site 661367000947 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 661367000948 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 661367000949 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 661367000950 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 661367000951 [2Fe-2S] cluster binding site [ion binding]; other site 661367000952 cytochrome b; Validated; Region: CYTB; MTH00016 661367000953 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 661367000954 Qi binding site; other site 661367000955 intrachain domain interface; other site 661367000956 interchain domain interface [polypeptide binding]; other site 661367000957 heme bH binding site [chemical binding]; other site 661367000958 heme bL binding site [chemical binding]; other site 661367000959 Qo binding site; other site 661367000960 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 661367000961 interchain domain interface [polypeptide binding]; other site 661367000962 intrachain domain interface; other site 661367000963 Qi binding site; other site 661367000964 Qo binding site; other site 661367000965 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 661367000966 stringent starvation protein A; Provisional; Region: sspA; PRK09481 661367000967 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 661367000968 C-terminal domain interface [polypeptide binding]; other site 661367000969 putative GSH binding site (G-site) [chemical binding]; other site 661367000970 dimer interface [polypeptide binding]; other site 661367000971 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 661367000972 dimer interface [polypeptide binding]; other site 661367000973 N-terminal domain interface [polypeptide binding]; other site 661367000974 Stringent starvation protein B; Region: SspB; cl01120 661367000975 putative carbohydrate kinase; Provisional; Region: PRK10565 661367000976 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 661367000977 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 661367000978 putative substrate binding site [chemical binding]; other site 661367000979 putative ATP binding site [chemical binding]; other site 661367000980 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 661367000981 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 661367000982 AMIN domain; Region: AMIN; pfam11741 661367000983 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 661367000984 active site 661367000985 metal binding site [ion binding]; metal-binding site 661367000986 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 661367000987 putative peptidoglycan binding site; other site 661367000988 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 661367000989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 661367000990 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 661367000991 ATP binding site [chemical binding]; other site 661367000992 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 661367000993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367000994 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 661367000995 Zinc-finger domain; Region: zf-CHCC; cl01821 661367000996 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 661367000997 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 661367000998 putative active site [active] 661367000999 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 661367001000 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 661367001001 metal-binding site [ion binding] 661367001002 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367001003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367001004 motif II; other site 661367001005 Phagosome trafficking protein DotA; Region: DotA; pfam11388 661367001006 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 661367001007 active site 661367001008 catalytic residues [active] 661367001009 metal binding site [ion binding]; metal-binding site 661367001010 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 661367001011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367001012 Walker A motif; other site 661367001013 ATP binding site [chemical binding]; other site 661367001014 Walker B motif; other site 661367001015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001016 S-adenosylmethionine binding site [chemical binding]; other site 661367001017 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 661367001018 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 661367001019 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 661367001020 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 661367001021 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 661367001022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 661367001023 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 661367001024 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 661367001025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 661367001026 P loop; other site 661367001027 GTP binding site [chemical binding]; other site 661367001028 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 661367001029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367001030 Walker A/P-loop; other site 661367001031 ATP binding site [chemical binding]; other site 661367001032 Q-loop/lid; other site 661367001033 ABC transporter signature motif; other site 661367001034 Walker B; other site 661367001035 D-loop; other site 661367001036 H-loop/switch region; other site 661367001037 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 661367001038 FtsX-like permease family; Region: FtsX; cl15850 661367001039 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 661367001040 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367001041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367001042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367001043 DNA binding residues [nucleotide binding] 661367001044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367001045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367001046 Dienelactone hydrolase family; Region: DLH; pfam01738 661367001047 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 661367001048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001049 binding surface 661367001050 TPR motif; other site 661367001051 TPR repeat; Region: TPR_11; pfam13414 661367001052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001053 binding surface 661367001054 TPR repeat; Region: TPR_11; pfam13414 661367001055 TPR motif; other site 661367001056 TPR repeat; Region: TPR_11; pfam13414 661367001057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001058 binding surface 661367001059 TPR motif; other site 661367001060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 661367001061 TPR repeat; Region: TPR_11; pfam13414 661367001062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001063 binding surface 661367001064 TPR motif; other site 661367001065 TPR repeat; Region: TPR_11; pfam13414 661367001066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367001067 binding surface 661367001068 TPR repeat; Region: TPR_11; pfam13414 661367001069 TPR motif; other site 661367001070 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 661367001071 Tetratricopeptide repeat; Region: TPR_6; pfam13174 661367001072 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367001073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001074 NAD(P) binding site [chemical binding]; other site 661367001075 active site 661367001076 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 661367001077 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 661367001078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001079 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367001080 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 661367001081 DXD motif; other site 661367001082 pantoate--beta-alanine ligase; Region: panC; TIGR00018 661367001083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367001084 active site 661367001085 nucleotide binding site [chemical binding]; other site 661367001086 HIGH motif; other site 661367001087 KMSKS motif; other site 661367001088 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 661367001089 oligomerization interface [polypeptide binding]; other site 661367001090 active site 661367001091 metal binding site [ion binding]; metal-binding site 661367001092 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 661367001093 Predicted ATPase [General function prediction only]; Region: COG1485 661367001094 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 661367001095 Walker A/P-loop; other site 661367001096 ATP binding site [chemical binding]; other site 661367001097 ABC transporter signature motif; other site 661367001098 Walker B; other site 661367001099 D-loop; other site 661367001100 H-loop/switch region; other site 661367001101 FeoA domain; Region: FeoA; cl00838 661367001102 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 661367001103 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 661367001104 G1 box; other site 661367001105 GTP/Mg2+ binding site [chemical binding]; other site 661367001106 Switch I region; other site 661367001107 G2 box; other site 661367001108 G3 box; other site 661367001109 Switch II region; other site 661367001110 G4 box; other site 661367001111 G5 box; other site 661367001112 Nucleoside recognition; Region: Gate; cl00486 661367001113 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 661367001114 Nucleoside recognition; Region: Gate; cl00486 661367001115 Helix-turn-helix domains; Region: HTH; cl00088 661367001116 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 661367001117 Iron-sulfur protein interface; other site 661367001118 proximal quinone binding site [chemical binding]; other site 661367001119 SdhD (CybS) interface [polypeptide binding]; other site 661367001120 proximal heme binding site [chemical binding]; other site 661367001121 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 661367001122 SdhC subunit interface [polypeptide binding]; other site 661367001123 proximal heme binding site [chemical binding]; other site 661367001124 cardiolipin binding site; other site 661367001125 Iron-sulfur protein interface; other site 661367001126 proximal quinone binding site [chemical binding]; other site 661367001127 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 661367001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001129 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367001130 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 661367001131 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 661367001132 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 661367001133 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 661367001134 TPP-binding site [chemical binding]; other site 661367001135 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 661367001136 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 661367001137 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367001138 E3 interaction surface; other site 661367001139 lipoyl attachment site [posttranslational modification]; other site 661367001140 e3 binding domain; Region: E3_binding; pfam02817 661367001141 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 661367001142 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 661367001143 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367001144 CoA-ligase; Region: Ligase_CoA; cl02894 661367001145 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 661367001146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001147 CoA-ligase; Region: Ligase_CoA; cl02894 661367001148 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 661367001149 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 661367001150 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 661367001151 Ribosome modulation factor; Region: RMF; cl01207 661367001152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001153 D-galactonate transporter; Region: 2A0114; TIGR00893 661367001154 putative substrate translocation pore; other site 661367001155 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 661367001156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 661367001157 Helix-turn-helix domains; Region: HTH; cl00088 661367001158 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 661367001159 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 661367001160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001161 active site 661367001162 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 661367001163 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 661367001164 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 661367001165 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 661367001166 active site 661367001167 (T/H)XGH motif; other site 661367001168 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 661367001169 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 661367001170 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 661367001171 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 661367001172 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 661367001173 DXD motif; other site 661367001174 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367001175 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001176 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 661367001177 putative acyl-acceptor binding pocket; other site 661367001178 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 661367001179 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 661367001180 DNA binding site [nucleotide binding] 661367001181 catalytic residue [active] 661367001182 H2TH interface [polypeptide binding]; other site 661367001183 putative catalytic residues [active] 661367001184 turnover-facilitating residue; other site 661367001185 intercalation triad [nucleotide binding]; other site 661367001186 8OG recognition residue [nucleotide binding]; other site 661367001187 putative reading head residues; other site 661367001188 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 661367001189 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 661367001190 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367001191 Di-iron ligands [ion binding]; other site 661367001192 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367001193 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 661367001194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001195 NAD(P) binding site [chemical binding]; other site 661367001196 active site 661367001197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001198 NAD(P) binding site [chemical binding]; other site 661367001199 active site 661367001200 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 661367001201 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 661367001202 Phasin protein; Region: Phasin_2; cl11491 661367001203 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 661367001204 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 661367001205 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 661367001206 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 661367001207 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001208 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001209 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001210 Dot/Icm substrate protein; Region: SidE; pfam12252 661367001211 Pirin-related protein [General function prediction only]; Region: COG1741 661367001212 Cupin domain; Region: Cupin_2; cl09118 661367001213 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 661367001214 malate dehydrogenase; Provisional; Region: PRK13529 661367001215 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367001216 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 661367001217 NAD(P) binding site [chemical binding]; other site 661367001218 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 661367001219 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 661367001220 putative C-terminal domain interface [polypeptide binding]; other site 661367001221 putative GSH binding site [chemical binding]; other site 661367001222 putative dimer interface [polypeptide binding]; other site 661367001223 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 661367001224 putative N-terminal domain interface [polypeptide binding]; other site 661367001225 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 661367001226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367001227 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367001228 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 661367001229 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 661367001230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367001231 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367001232 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367001233 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367001234 OpgC protein; Region: OpgC_C; cl00792 661367001235 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367001236 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 661367001237 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 661367001238 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 661367001239 substrate binding site [chemical binding]; other site 661367001240 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 661367001241 nucleotide binding site/active site [active] 661367001242 HIT family signature motif; other site 661367001243 catalytic residue [active] 661367001244 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 661367001245 catalytic residues [active] 661367001246 dimer interface [polypeptide binding]; other site 661367001247 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367001248 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 661367001249 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367001250 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367001251 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 661367001252 Walker A/P-loop; other site 661367001253 ATP binding site [chemical binding]; other site 661367001254 Q-loop/lid; other site 661367001255 ABC transporter signature motif; other site 661367001256 Walker B; other site 661367001257 D-loop; other site 661367001258 H-loop/switch region; other site 661367001259 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367001260 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001261 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001262 YhhN-like protein; Region: YhhN; cl01505 661367001263 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 661367001264 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348 661367001265 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 661367001266 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 661367001267 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 661367001268 substrate binding site [chemical binding]; other site 661367001269 ATP binding site [chemical binding]; other site 661367001270 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 661367001271 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367001272 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 661367001273 putative dimer interface [polypeptide binding]; other site 661367001274 N-terminal domain interface [polypeptide binding]; other site 661367001275 putative substrate binding pocket (H-site) [chemical binding]; other site 661367001276 aconitate hydratase; Validated; Region: PRK07229 661367001277 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 661367001278 substrate binding site [chemical binding]; other site 661367001279 ligand binding site [chemical binding]; other site 661367001280 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 661367001281 substrate binding site [chemical binding]; other site 661367001282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001283 active site 661367001284 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 661367001285 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 661367001286 putative NAD(P) binding site [chemical binding]; other site 661367001287 homotetramer interface [polypeptide binding]; other site 661367001288 homodimer interface [polypeptide binding]; other site 661367001289 active site 661367001290 elongation factor P; Validated; Region: PRK00529 661367001291 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 661367001292 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 661367001293 RNA binding site [nucleotide binding]; other site 661367001294 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 661367001295 RNA binding site [nucleotide binding]; other site 661367001296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 661367001297 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 661367001298 dimer interface [polypeptide binding]; other site 661367001299 catalytic triad [active] 661367001300 polyphosphate kinase; Provisional; Region: PRK05443 661367001301 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 661367001302 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 661367001303 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 661367001304 putative active site [active] 661367001305 catalytic site [active] 661367001306 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 661367001307 putative domain interface [polypeptide binding]; other site 661367001308 putative active site [active] 661367001309 catalytic site [active] 661367001310 Chromate transporter; Region: Chromate_transp; pfam02417 661367001311 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 661367001312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367001313 active site 661367001314 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 661367001315 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 661367001316 Substrate binding site; other site 661367001317 metal-binding site 661367001318 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367001319 Phosphotransferase enzyme family; Region: APH; pfam01636 661367001320 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 661367001321 OstA-like protein; Region: OstA; cl00844 661367001322 Organic solvent tolerance protein; Region: OstA_C; pfam04453 661367001323 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 661367001324 SurA N-terminal domain; Region: SurA_N_3; cl07813 661367001325 PPIC-type PPIASE domain; Region: Rotamase; cl08278 661367001326 PPIC-type PPIASE domain; Region: Rotamase; cl08278 661367001327 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 661367001328 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 661367001329 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 661367001330 folate binding site [chemical binding]; other site 661367001331 NADP+ binding site [chemical binding]; other site 661367001332 elongation factor Tu; Reviewed; Region: PRK00049 661367001333 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 661367001334 G1 box; other site 661367001335 GEF interaction site [polypeptide binding]; other site 661367001336 GTP/Mg2+ binding site [chemical binding]; other site 661367001337 Switch I region; other site 661367001338 G2 box; other site 661367001339 G3 box; other site 661367001340 Switch II region; other site 661367001341 G4 box; other site 661367001342 G5 box; other site 661367001343 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 661367001344 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 661367001345 Antibiotic Binding Site [chemical binding]; other site 661367001346 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 661367001347 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 661367001348 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 661367001349 putative homodimer interface [polypeptide binding]; other site 661367001350 KOW motif; Region: KOW; cl00354 661367001351 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 661367001352 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 661367001353 23S rRNA interface [nucleotide binding]; other site 661367001354 L7/L12 interface [polypeptide binding]; other site 661367001355 putative thiostrepton binding site; other site 661367001356 L25 interface [polypeptide binding]; other site 661367001357 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 661367001358 mRNA/rRNA interface [nucleotide binding]; other site 661367001359 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 661367001360 23S rRNA interface [nucleotide binding]; other site 661367001361 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 661367001362 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 661367001363 peripheral dimer interface [polypeptide binding]; other site 661367001364 core dimer interface [polypeptide binding]; other site 661367001365 L10 interface [polypeptide binding]; other site 661367001366 L11 interface [polypeptide binding]; other site 661367001367 putative EF-Tu interaction site [polypeptide binding]; other site 661367001368 putative EF-G interaction site [polypeptide binding]; other site 661367001369 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 661367001370 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 661367001371 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 661367001372 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 661367001373 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 661367001374 RPB11 interaction site [polypeptide binding]; other site 661367001375 RPB12 interaction site [polypeptide binding]; other site 661367001376 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 661367001377 RPB3 interaction site [polypeptide binding]; other site 661367001378 RPB1 interaction site [polypeptide binding]; other site 661367001379 RPB11 interaction site [polypeptide binding]; other site 661367001380 RPB10 interaction site [polypeptide binding]; other site 661367001381 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 661367001382 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 661367001383 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 661367001384 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 661367001385 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 661367001386 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 661367001387 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 661367001388 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 661367001389 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 661367001390 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 661367001391 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 661367001392 DNA binding site [nucleotide binding] 661367001393 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 661367001394 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 661367001395 S17 interaction site [polypeptide binding]; other site 661367001396 S8 interaction site; other site 661367001397 16S rRNA interaction site [nucleotide binding]; other site 661367001398 streptomycin interaction site [chemical binding]; other site 661367001399 23S rRNA interaction site [nucleotide binding]; other site 661367001400 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 661367001401 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 661367001402 elongation factor G; Reviewed; Region: PRK00007 661367001403 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 661367001404 G1 box; other site 661367001405 putative GEF interaction site [polypeptide binding]; other site 661367001406 GTP/Mg2+ binding site [chemical binding]; other site 661367001407 Switch I region; other site 661367001408 G2 box; other site 661367001409 G3 box; other site 661367001410 Switch II region; other site 661367001411 G4 box; other site 661367001412 G5 box; other site 661367001413 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 661367001414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 661367001415 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 661367001416 elongation factor Tu; Reviewed; Region: PRK00049 661367001417 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 661367001418 G1 box; other site 661367001419 GEF interaction site [polypeptide binding]; other site 661367001420 GTP/Mg2+ binding site [chemical binding]; other site 661367001421 Switch I region; other site 661367001422 G2 box; other site 661367001423 G3 box; other site 661367001424 Switch II region; other site 661367001425 G4 box; other site 661367001426 G5 box; other site 661367001427 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 661367001428 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 661367001429 Antibiotic Binding Site [chemical binding]; other site 661367001430 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 661367001431 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 661367001432 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 661367001433 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 661367001434 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 661367001435 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 661367001436 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 661367001437 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 661367001438 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 661367001439 putative translocon binding site; other site 661367001440 protein-rRNA interface [nucleotide binding]; other site 661367001441 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 661367001442 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 661367001443 G-X-X-G motif; other site 661367001444 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 661367001445 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 661367001446 23S rRNA interface [nucleotide binding]; other site 661367001447 5S rRNA interface [nucleotide binding]; other site 661367001448 putative antibiotic binding site [chemical binding]; other site 661367001449 L25 interface [polypeptide binding]; other site 661367001450 L27 interface [polypeptide binding]; other site 661367001451 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 661367001452 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 661367001453 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 661367001454 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 661367001455 KOW motif; Region: KOW; cl00354 661367001456 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 661367001457 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 661367001458 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 661367001459 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 661367001460 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 661367001461 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 661367001462 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 661367001463 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 661367001464 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 661367001465 23S rRNA interface [nucleotide binding]; other site 661367001466 L21e interface [polypeptide binding]; other site 661367001467 5S rRNA interface [nucleotide binding]; other site 661367001468 L27 interface [polypeptide binding]; other site 661367001469 L5 interface [polypeptide binding]; other site 661367001470 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 661367001471 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 661367001472 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 661367001473 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 661367001474 23S rRNA binding site [nucleotide binding]; other site 661367001475 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 661367001476 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 661367001477 SecY translocase; Region: SecY; pfam00344 661367001478 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 661367001479 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 661367001480 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 661367001481 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 661367001482 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 661367001483 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367001484 RNA binding surface [nucleotide binding]; other site 661367001485 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 661367001486 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 661367001487 alphaNTD homodimer interface [polypeptide binding]; other site 661367001488 alphaNTD - beta interaction site [polypeptide binding]; other site 661367001489 alphaNTD - beta' interaction site [polypeptide binding]; other site 661367001490 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 661367001491 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 661367001492 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 661367001493 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 661367001494 dimer interface [polypeptide binding]; other site 661367001495 ssDNA binding site [nucleotide binding]; other site 661367001496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 661367001497 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 661367001498 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 661367001499 DNA binding residues [nucleotide binding] 661367001500 dimer interface [polypeptide binding]; other site 661367001501 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 661367001502 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 661367001503 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 661367001504 chaperone protein HchA; Provisional; Region: PRK04155 661367001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367001507 putative substrate translocation pore; other site 661367001508 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 661367001509 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 661367001510 putative NAD(P) binding site [chemical binding]; other site 661367001511 active site 661367001512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367001513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 661367001514 active site 2 [active] 661367001515 active site 1 [active] 661367001516 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 661367001517 active site 2 [active] 661367001518 dimer interface [polypeptide binding]; other site 661367001519 active site 1 [active] 661367001520 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367001521 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367001522 dimer interface [polypeptide binding]; other site 661367001523 active site 661367001524 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 661367001525 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367001526 dimer interface [polypeptide binding]; other site 661367001527 active site 661367001528 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 661367001529 putative acyl-acceptor binding pocket; other site 661367001530 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 661367001531 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 661367001532 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 661367001533 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 661367001534 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367001535 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 661367001536 putative coenzyme Q binding site [chemical binding]; other site 661367001537 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 661367001538 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 661367001539 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 661367001540 metal binding site 2 [ion binding]; metal-binding site 661367001541 putative DNA binding helix; other site 661367001542 metal binding site 1 [ion binding]; metal-binding site 661367001543 dimer interface [polypeptide binding]; other site 661367001544 structural Zn2+ binding site [ion binding]; other site 661367001545 cyclase homology domain; Region: CHD; cd07302 661367001546 nucleotidyl binding site; other site 661367001547 metal binding site [ion binding]; metal-binding site 661367001548 dimer interface [polypeptide binding]; other site 661367001549 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367001550 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 661367001551 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367001552 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001553 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001554 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001555 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 661367001556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367001557 putative substrate translocation pore; other site 661367001558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367001559 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 661367001560 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001561 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001562 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001563 Entericidin EcnA/B family; Region: Entericidin; cl02322 661367001564 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 661367001565 AMP-binding enzyme; Region: AMP-binding; cl15778 661367001566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367001567 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367001568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001569 NAD(P) binding site [chemical binding]; other site 661367001570 active site 661367001571 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 661367001572 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367001573 dimer interface [polypeptide binding]; other site 661367001574 active site 661367001575 CoA binding pocket [chemical binding]; other site 661367001576 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001577 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367001578 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001579 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001580 multidrug efflux protein; Reviewed; Region: PRK09579 661367001581 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 661367001582 CoenzymeA binding site [chemical binding]; other site 661367001583 subunit interaction site [polypeptide binding]; other site 661367001584 PHB binding site; other site 661367001585 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367001586 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 661367001587 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 661367001588 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 661367001589 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 661367001590 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 661367001591 LemA family; Region: LemA; cl00742 661367001592 Peptidase family M48; Region: Peptidase_M48; cl12018 661367001593 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 661367001594 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 661367001595 putative metal binding site [ion binding]; other site 661367001596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367001597 HSP70 interaction site [polypeptide binding]; other site 661367001598 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 661367001599 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 661367001600 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367001601 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 661367001602 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 661367001603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001604 S-adenosylmethionine binding site [chemical binding]; other site 661367001605 peptide chain release factor 1; Validated; Region: prfA; PRK00591 661367001606 RF-1 domain; Region: RF-1; cl02875 661367001607 RF-1 domain; Region: RF-1; cl02875 661367001608 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 661367001609 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 661367001610 tRNA; other site 661367001611 putative tRNA binding site [nucleotide binding]; other site 661367001612 putative NADP binding site [chemical binding]; other site 661367001613 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 661367001614 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 661367001615 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367001616 active site 661367001617 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367001618 protein binding site [polypeptide binding]; other site 661367001619 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 661367001620 putative substrate binding region [chemical binding]; other site 661367001621 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 661367001622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367001623 active site 661367001624 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 661367001625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001626 S-adenosylmethionine binding site [chemical binding]; other site 661367001627 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367001628 substrate binding pocket [chemical binding]; other site 661367001629 chain length determination region; other site 661367001630 substrate-Mg2+ binding site; other site 661367001631 catalytic residues [active] 661367001632 aspartate-rich region 1; other site 661367001633 active site lid residues [active] 661367001634 aspartate-rich region 2; other site 661367001635 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 661367001636 DNA repair protein RadA; Provisional; Region: PRK11823 661367001637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367001638 Walker A motif; other site 661367001639 ATP binding site [chemical binding]; other site 661367001640 Walker B motif; other site 661367001641 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 661367001642 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 661367001643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367001644 Walker A motif; other site 661367001645 ATP binding site [chemical binding]; other site 661367001646 Walker B motif; other site 661367001647 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367001648 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 661367001649 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367001650 GIY-YIG motif/motif A; other site 661367001651 putative active site [active] 661367001652 putative metal binding site [ion binding]; other site 661367001653 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 661367001654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001655 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 661367001656 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 661367001657 SecA binding site; other site 661367001658 Preprotein binding site; other site 661367001659 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 661367001660 GSH binding site [chemical binding]; other site 661367001661 catalytic residues [active] 661367001662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367001663 active site residue [active] 661367001664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 661367001665 Smr domain; Region: Smr; cl02619 661367001666 HemK family putative methylases; Region: hemK_fam; TIGR00536 661367001667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001668 S-adenosylmethionine binding site [chemical binding]; other site 661367001669 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 661367001670 Tetramer interface [polypeptide binding]; other site 661367001671 active site 661367001672 FMN-binding site [chemical binding]; other site 661367001673 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 661367001674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001675 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 661367001676 Smr domain; Region: Smr; cl02619 661367001677 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367001678 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367001679 hypothetical protein; Provisional; Region: PRK13682 661367001680 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367001681 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 661367001682 putative NAD(P) binding site [chemical binding]; other site 661367001683 putative substrate binding site [chemical binding]; other site 661367001684 catalytic Zn binding site [ion binding]; other site 661367001685 structural Zn binding site [ion binding]; other site 661367001686 dimer interface [polypeptide binding]; other site 661367001687 ribonuclease E; Reviewed; Region: rne; PRK10811 661367001688 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 661367001689 homodimer interface [polypeptide binding]; other site 661367001690 oligonucleotide binding site [chemical binding]; other site 661367001691 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 661367001692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 661367001693 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 661367001694 active site 661367001695 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 661367001696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367001697 motif II; other site 661367001698 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367001699 EamA-like transporter family; Region: EamA; cl01037 661367001700 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 661367001701 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367001702 FtsX-like permease family; Region: FtsX; cl15850 661367001703 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 661367001704 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 661367001705 Walker A/P-loop; other site 661367001706 ATP binding site [chemical binding]; other site 661367001707 Q-loop/lid; other site 661367001708 ABC transporter signature motif; other site 661367001709 Walker B; other site 661367001710 D-loop; other site 661367001711 H-loop/switch region; other site 661367001712 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 661367001713 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 661367001714 putative dimer interface [polypeptide binding]; other site 661367001715 putative anticodon binding site; other site 661367001716 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 661367001717 homodimer interface [polypeptide binding]; other site 661367001718 motif 1; other site 661367001719 motif 2; other site 661367001720 active site 661367001721 motif 3; other site 661367001722 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 661367001723 maleylacetoacetate isomerase; Region: maiA; TIGR01262 661367001724 C-terminal domain interface [polypeptide binding]; other site 661367001725 GSH binding site (G-site) [chemical binding]; other site 661367001726 putative dimer interface [polypeptide binding]; other site 661367001727 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 661367001728 dimer interface [polypeptide binding]; other site 661367001729 N-terminal domain interface [polypeptide binding]; other site 661367001730 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 661367001731 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 661367001732 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 661367001733 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 661367001734 dimer interface [polypeptide binding]; other site 661367001735 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 661367001736 active site 661367001737 Fe binding site [ion binding]; other site 661367001738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001739 O-methyltransferase; Region: Methyltransf_3; pfam01596 661367001740 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 661367001741 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 661367001742 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 661367001743 NAD binding site [chemical binding]; other site 661367001744 Phe binding site; other site 661367001745 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 661367001746 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 661367001747 putative active site [active] 661367001748 catalytic site [active] 661367001749 putative metal binding site [ion binding]; other site 661367001750 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 661367001751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 661367001752 lytic murein transglycosylase; Provisional; Region: PRK11619 661367001753 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 661367001754 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367001755 catalytic residue [active] 661367001756 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 661367001757 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 661367001758 substrate binding site [chemical binding]; other site 661367001759 hexamer interface [polypeptide binding]; other site 661367001760 metal binding site [ion binding]; metal-binding site 661367001761 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 661367001762 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 661367001763 metal binding triad; other site 661367001764 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 661367001765 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 661367001766 metal binding triad; other site 661367001767 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 661367001768 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 661367001769 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367001770 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 661367001771 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 661367001772 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367001773 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 661367001774 DsbD alpha interface [polypeptide binding]; other site 661367001775 catalytic residues [active] 661367001776 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 661367001777 oligomerisation interface [polypeptide binding]; other site 661367001778 mobile loop; other site 661367001779 roof hairpin; other site 661367001780 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 661367001781 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 661367001782 ring oligomerisation interface [polypeptide binding]; other site 661367001783 ATP/Mg binding site [chemical binding]; other site 661367001784 stacking interactions; other site 661367001785 hinge regions; other site 661367001786 Ferritin-like domain; Region: Ferritin; pfam00210 661367001787 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 661367001788 dimerization interface [polypeptide binding]; other site 661367001789 DPS ferroxidase diiron center [ion binding]; other site 661367001790 ion pore; other site 661367001791 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 661367001792 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 661367001793 classical (c) SDRs; Region: SDR_c; cd05233 661367001794 NAD(P) binding site [chemical binding]; other site 661367001795 active site 661367001796 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 661367001797 dihydrodipicolinate synthase; Region: dapA; TIGR00674 661367001798 dimer interface [polypeptide binding]; other site 661367001799 active site 661367001800 catalytic residue [active] 661367001801 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 661367001802 conserved hypothetical protein; Region: QEGLA; TIGR02421 661367001803 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 661367001804 Zeta toxin; Region: Zeta_toxin; pfam06414 661367001805 16S rRNA methyltransferase B; Provisional; Region: PRK10901 661367001806 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 661367001807 putative RNA binding site [nucleotide binding]; other site 661367001808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367001809 S-adenosylmethionine binding site [chemical binding]; other site 661367001810 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 661367001811 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 661367001812 putative active site [active] 661367001813 substrate binding site [chemical binding]; other site 661367001814 putative cosubstrate binding site; other site 661367001815 catalytic site [active] 661367001816 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 661367001817 substrate binding site [chemical binding]; other site 661367001818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 661367001819 active site 661367001820 catalytic residues [active] 661367001821 metal binding site [ion binding]; metal-binding site 661367001822 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 661367001823 putative peptidoglycan binding site; other site 661367001824 hypothetical protein; Provisional; Region: PRK10736 661367001825 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 661367001826 Protein of unknown function (DUF494); Region: DUF494; cl01103 661367001827 DNA topoisomerase I; Validated; Region: PRK06599 661367001828 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 661367001829 active site 661367001830 interdomain interaction site; other site 661367001831 putative metal-binding site [ion binding]; other site 661367001832 nucleotide binding site [chemical binding]; other site 661367001833 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 661367001834 domain I; other site 661367001835 DNA binding groove [nucleotide binding] 661367001836 phosphate binding site [ion binding]; other site 661367001837 domain II; other site 661367001838 domain III; other site 661367001839 nucleotide binding site [chemical binding]; other site 661367001840 catalytic site [active] 661367001841 domain IV; other site 661367001842 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001843 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 661367001844 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001845 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 661367001846 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 661367001847 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 661367001848 tetramer interface [polypeptide binding]; other site 661367001849 TPP-binding site [chemical binding]; other site 661367001850 heterodimer interface [polypeptide binding]; other site 661367001851 phosphorylation loop region [posttranslational modification] 661367001852 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 661367001853 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 661367001854 alpha subunit interface [polypeptide binding]; other site 661367001855 TPP binding site [chemical binding]; other site 661367001856 heterodimer interface [polypeptide binding]; other site 661367001857 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367001858 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367001859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367001860 active site 661367001861 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 661367001862 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) [Translation, ribosomal structure and biogenesis]; Region: Pnp; COG1185 661367001863 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 661367001864 Uncharacterized conserved protein [Function unknown]; Region: COG3410 661367001865 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 661367001866 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 661367001867 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 661367001868 active site 661367001869 Zn binding site [ion binding]; other site 661367001870 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 661367001871 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367001872 Divergent AAA domain; Region: AAA_4; pfam04326 661367001873 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 661367001874 integrase; Provisional; Region: PRK09692 661367001875 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 661367001876 active site 661367001877 Int/Topo IB signature motif; other site 661367001878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367001879 non-specific DNA binding site [nucleotide binding]; other site 661367001880 salt bridge; other site 661367001881 sequence-specific DNA binding site [nucleotide binding]; other site 661367001882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367001883 PAS fold; Region: PAS_4; pfam08448 661367001884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 661367001885 Zn2+ binding site [ion binding]; other site 661367001886 Mg2+ binding site [ion binding]; other site 661367001887 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 661367001888 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367001889 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 661367001890 putative NAD(P) binding site [chemical binding]; other site 661367001891 FOG: CBS domain [General function prediction only]; Region: COG0517 661367001892 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619 661367001893 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 661367001894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 661367001895 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 661367001896 Iron-sulfur protein interface; other site 661367001897 proximal quinone binding site [chemical binding]; other site 661367001898 SdhD (CybS) interface [polypeptide binding]; other site 661367001899 proximal heme binding site [chemical binding]; other site 661367001900 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 661367001901 SdhC subunit interface [polypeptide binding]; other site 661367001902 proximal heme binding site [chemical binding]; other site 661367001903 cardiolipin binding site; other site 661367001904 Iron-sulfur protein interface; other site 661367001905 proximal quinone binding site [chemical binding]; other site 661367001906 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 661367001907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367001908 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367001909 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367001910 endonuclease III; Region: ENDO3c; smart00478 661367001911 minor groove reading motif; other site 661367001912 helix-hairpin-helix signature motif; other site 661367001913 substrate binding pocket [chemical binding]; other site 661367001914 active site 661367001915 Protein of unknown function, DUF488; Region: DUF488; cl01246 661367001916 aconitate hydratase; Validated; Region: PRK09277 661367001917 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367001918 substrate binding site [chemical binding]; other site 661367001919 ligand binding site [chemical binding]; other site 661367001920 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367001921 substrate binding site [chemical binding]; other site 661367001922 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 661367001923 Rubredoxin; Region: Rubredoxin; pfam00301 661367001924 iron binding site [ion binding]; other site 661367001925 OsmC-like protein; Region: OsmC; cl00767 661367001926 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 661367001927 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367001928 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104 661367001929 Predicted acetyltransferase [General function prediction only]; Region: COG3393 661367001930 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367001931 Protein of unknown function (DUF812); Region: DUF812; pfam05667 661367001932 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 661367001933 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 661367001934 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 661367001935 Protein of unknown function (DUF423); Region: DUF423; cl01008 661367001936 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 661367001937 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 661367001938 Helix-turn-helix domains; Region: HTH; cl00088 661367001939 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 661367001940 motif 1; other site 661367001941 dimer interface [polypeptide binding]; other site 661367001942 active site 661367001943 motif 2; other site 661367001944 motif 3; other site 661367001945 large T antigen; Provisional; Region: PHA02624 661367001946 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367001947 HSP70 interaction site [polypeptide binding]; other site 661367001948 Cupin domain; Region: Cupin_2; cl09118 661367001949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 661367001950 sensory histidine kinase AtoS; Provisional; Region: PRK11360 661367001951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367001952 dimer interface [polypeptide binding]; other site 661367001953 phosphorylation site [posttranslational modification] 661367001954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367001955 ATP binding site [chemical binding]; other site 661367001956 Mg2+ binding site [ion binding]; other site 661367001957 G-X-G motif; other site 661367001958 Response regulator receiver domain; Region: Response_reg; pfam00072 661367001959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367001960 active site 661367001961 phosphorylation site [posttranslational modification] 661367001962 intermolecular recognition site; other site 661367001963 dimerization interface [polypeptide binding]; other site 661367001964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367001965 dimer interface [polypeptide binding]; other site 661367001966 phosphorylation site [posttranslational modification] 661367001967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367001968 ATP binding site [chemical binding]; other site 661367001969 Mg2+ binding site [ion binding]; other site 661367001970 G-X-G motif; other site 661367001971 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367001972 putative active site [active] 661367001973 GIY-YIG motif/motif A; other site 661367001974 putative metal binding site [ion binding]; other site 661367001975 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 661367001976 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367001977 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001978 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367001979 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367001980 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367001981 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367001982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367001983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367001984 P-loop motif; other site 661367001985 ATP binding site [chemical binding]; other site 661367001986 Chloramphenicol (Cm) binding site [chemical binding]; other site 661367001987 catalytic residue [active] 661367001988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 661367001989 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367001990 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367001991 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 661367001992 metal binding site 2 [ion binding]; metal-binding site 661367001993 putative DNA binding helix; other site 661367001994 metal binding site 1 [ion binding]; metal-binding site 661367001995 dimer interface [polypeptide binding]; other site 661367001996 structural Zn2+ binding site [ion binding]; other site 661367001997 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367001998 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367001999 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367002000 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367002001 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 661367002002 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 661367002003 hypothetical protein; Reviewed; Region: PRK09588 661367002004 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 661367002005 EamA-like transporter family; Region: EamA; cl01037 661367002006 EamA-like transporter family; Region: EamA; cl01037 661367002007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 661367002008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 661367002009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002010 S-adenosylmethionine binding site [chemical binding]; other site 661367002011 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002012 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002013 active site 661367002014 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002015 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002016 active site 661367002017 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367002018 putative NADP binding site [chemical binding]; other site 661367002019 active site 661367002020 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002021 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002022 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002023 active site 661367002024 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 661367002025 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 661367002026 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367002027 putative NADP binding site [chemical binding]; other site 661367002028 active site 661367002029 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002030 Condensation domain; Region: Condensation; pfam00668 661367002031 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 661367002032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367002033 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367002034 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 661367002035 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 661367002036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002037 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 661367002038 L-serine binding site [chemical binding]; other site 661367002039 ACT domain interface; other site 661367002040 phosphoserine phosphatase SerB; Region: serB; TIGR00338 661367002041 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367002042 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367002043 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367002044 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367002045 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367002046 ligand binding site [chemical binding]; other site 661367002047 flexible hinge region; other site 661367002048 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367002049 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 661367002050 Erythromycin esterase; Region: Erythro_esteras; pfam05139 661367002051 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 661367002052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367002053 Walker A motif; other site 661367002054 ATP binding site [chemical binding]; other site 661367002055 Walker B motif; other site 661367002056 arginine finger; other site 661367002057 Peptidase family M41; Region: Peptidase_M41; pfam01434 661367002058 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367002059 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367002060 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 661367002061 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 661367002062 Predicted transporter component [General function prediction only]; Region: COG2391 661367002063 Sulphur transport; Region: Sulf_transp; cl01018 661367002064 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 661367002065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002066 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 661367002067 Isochorismatase family; Region: Isochorismatase; pfam00857 661367002068 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 661367002069 catalytic triad [active] 661367002070 conserved cis-peptide bond; other site 661367002071 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367002072 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 661367002073 putative FMN binding site [chemical binding]; other site 661367002074 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 661367002075 dimer interface [polypeptide binding]; other site 661367002076 catalytic triad [active] 661367002077 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 661367002078 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 661367002079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367002080 motif II; other site 661367002081 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 661367002082 active site 661367002083 catalytic residues [active] 661367002084 metal binding site [ion binding]; metal-binding site 661367002085 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367002086 ligand binding site [chemical binding]; other site 661367002087 flexible hinge region; other site 661367002088 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367002089 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 661367002090 active site 661367002091 nucleophile elbow; other site 661367002092 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 661367002093 MASE1; Region: MASE1; pfam05231 661367002094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367002095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367002096 dimer interface [polypeptide binding]; other site 661367002097 phosphorylation site [posttranslational modification] 661367002098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002099 ATP binding site [chemical binding]; other site 661367002100 Mg2+ binding site [ion binding]; other site 661367002101 G-X-G motif; other site 661367002102 Response regulator receiver domain; Region: Response_reg; pfam00072 661367002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367002104 active site 661367002105 phosphorylation site [posttranslational modification] 661367002106 intermolecular recognition site; other site 661367002107 dimerization interface [polypeptide binding]; other site 661367002108 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367002109 cyclase homology domain; Region: CHD; cd07302 661367002110 nucleotidyl binding site; other site 661367002111 metal binding site [ion binding]; metal-binding site 661367002112 dimer interface [polypeptide binding]; other site 661367002113 Protein of unknown function (DUF692); Region: DUF692; cl01263 661367002114 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 661367002115 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 661367002116 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 661367002117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367002118 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 661367002119 active site 661367002120 metal binding site [ion binding]; metal-binding site 661367002121 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 661367002122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367002123 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 661367002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002125 Mg2+ binding site [ion binding]; other site 661367002126 G-X-G motif; other site 661367002127 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 661367002128 anchoring element; other site 661367002129 dimer interface [polypeptide binding]; other site 661367002130 ATP binding site [chemical binding]; other site 661367002131 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 661367002132 active site 661367002133 metal binding site [ion binding]; metal-binding site 661367002134 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 661367002135 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 661367002136 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 661367002137 Walker A/P-loop; other site 661367002138 ATP binding site [chemical binding]; other site 661367002139 Q-loop/lid; other site 661367002140 ABC transporter signature motif; other site 661367002141 Walker B; other site 661367002142 D-loop; other site 661367002143 H-loop/switch region; other site 661367002144 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 661367002145 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 661367002146 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 661367002147 Walker A/P-loop; other site 661367002148 ATP binding site [chemical binding]; other site 661367002149 Q-loop/lid; other site 661367002150 ABC transporter signature motif; other site 661367002151 Walker B; other site 661367002152 D-loop; other site 661367002153 H-loop/switch region; other site 661367002154 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367002155 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 661367002156 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 661367002157 DJ-1 family protein; Region: not_thiJ; TIGR01383 661367002158 conserved cys residue [active] 661367002159 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367002160 NodB motif; other site 661367002161 putative active site [active] 661367002162 putative catalytic site [active] 661367002163 putative Zn binding site [ion binding]; other site 661367002164 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 661367002165 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 661367002166 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 661367002167 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 661367002168 Ligand binding site; other site 661367002169 Putative Catalytic site; other site 661367002170 DXD motif; other site 661367002171 GtrA-like protein; Region: GtrA; cl00971 661367002172 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 661367002173 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 661367002174 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 661367002175 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 661367002176 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 661367002177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367002178 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 661367002179 ATP-dependent helicase; Provisional; Region: PRK13767 661367002180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002181 ATP binding site [chemical binding]; other site 661367002182 putative Mg++ binding site [ion binding]; other site 661367002183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002184 nucleotide binding region [chemical binding]; other site 661367002185 ATP-binding site [chemical binding]; other site 661367002186 DEAD/H associated; Region: DEAD_assoc; pfam08494 661367002187 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367002188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002189 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 661367002190 catalytic triad [active] 661367002191 metal binding site [ion binding]; metal-binding site 661367002192 conserved cis-peptide bond; other site 661367002193 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 661367002194 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 661367002195 active site 661367002196 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 661367002197 putative active site [active] 661367002198 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 661367002199 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 661367002200 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 661367002201 putative NAD(P) binding site [chemical binding]; other site 661367002202 Nitronate monooxygenase; Region: NMO; pfam03060 661367002203 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 661367002204 FMN binding site [chemical binding]; other site 661367002205 substrate binding site [chemical binding]; other site 661367002206 putative catalytic residue [active] 661367002207 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367002208 GIY-YIG motif/motif A; other site 661367002209 active site 661367002210 catalytic site [active] 661367002211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 661367002212 MORN repeat; Region: MORN; cl14787 661367002213 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 661367002214 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 661367002215 active site clefts [active] 661367002216 zinc binding site [ion binding]; other site 661367002217 dimer interface [polypeptide binding]; other site 661367002218 Cysteine dioxygenase type I; Region: CDO_I; cl15835 661367002219 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 661367002220 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 661367002221 prolyl-tRNA synthetase; Provisional; Region: PRK09194 661367002222 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 661367002223 dimer interface [polypeptide binding]; other site 661367002224 motif 1; other site 661367002225 active site 661367002226 motif 2; other site 661367002227 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 661367002228 putative deacylase active site [active] 661367002229 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 661367002230 active site 661367002231 motif 3; other site 661367002232 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 661367002233 anticodon binding site; other site 661367002234 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367002235 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367002236 active site clefts [active] 661367002237 zinc binding site [ion binding]; other site 661367002238 dimer interface [polypeptide binding]; other site 661367002239 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 661367002240 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 661367002241 Ligand Binding Site [chemical binding]; other site 661367002242 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 661367002243 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 661367002244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002245 S-adenosylmethionine binding site [chemical binding]; other site 661367002246 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 661367002247 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 661367002248 substrate-cofactor binding pocket; other site 661367002249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367002250 catalytic residue [active] 661367002251 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 661367002252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002253 NAD(P) binding site [chemical binding]; other site 661367002254 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 661367002255 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002256 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002257 ABC transporter; Region: ABC_tran_2; pfam12848 661367002258 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 661367002260 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367002261 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367002262 Arginase family; Region: Arginase; cl00306 661367002263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002264 short chain dehydrogenase; Provisional; Region: PRK06924 661367002265 NAD(P) binding site [chemical binding]; other site 661367002266 active site 661367002267 imidazolonepropionase; Validated; Region: PRK09356 661367002268 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 661367002269 active site 661367002270 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 661367002271 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 661367002272 OPT oligopeptide transporter protein; Region: OPT; cl14607 661367002273 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 661367002274 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 661367002275 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 661367002276 HIGH motif; other site 661367002277 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367002278 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 661367002279 active site 661367002280 KMSKS motif; other site 661367002281 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 661367002282 tRNA binding surface [nucleotide binding]; other site 661367002283 anticodon binding site; other site 661367002284 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 661367002285 multidrug efflux protein; Reviewed; Region: PRK09579 661367002286 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367002287 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367002288 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367002289 BON domain; Region: BON; cl02771 661367002290 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 661367002291 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 661367002292 dimer interface [polypeptide binding]; other site 661367002293 glycine-pyridoxal phosphate binding site [chemical binding]; other site 661367002294 active site 661367002295 folate binding site [chemical binding]; other site 661367002296 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 661367002297 ATP cone domain; Region: ATP-cone; pfam03477 661367002298 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 661367002299 putative RNA binding site [nucleotide binding]; other site 661367002300 thiamine monophosphate kinase; Provisional; Region: PRK05731 661367002301 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 661367002302 ATP binding site [chemical binding]; other site 661367002303 dimerization interface [polypeptide binding]; other site 661367002304 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 661367002305 tetramer interfaces [polypeptide binding]; other site 661367002306 binuclear metal-binding site [ion binding]; other site 661367002307 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 661367002308 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 661367002309 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367002310 NAD synthetase; Provisional; Region: PRK13981 661367002311 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 661367002312 multimer interface [polypeptide binding]; other site 661367002313 active site 661367002314 catalytic triad [active] 661367002315 protein interface 1 [polypeptide binding]; other site 661367002316 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 661367002317 homodimer interface [polypeptide binding]; other site 661367002318 NAD binding pocket [chemical binding]; other site 661367002319 ATP binding pocket [chemical binding]; other site 661367002320 Mg binding site [ion binding]; other site 661367002321 active-site loop [active] 661367002322 Uncharacterized conserved protein [Function unknown]; Region: COG4715 661367002323 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 661367002324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002325 ATP binding site [chemical binding]; other site 661367002326 putative Mg++ binding site [ion binding]; other site 661367002327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002328 nucleotide binding region [chemical binding]; other site 661367002329 ATP-binding site [chemical binding]; other site 661367002330 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 661367002331 replicative DNA helicase; Region: DnaB; TIGR00665 661367002332 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 661367002333 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 661367002334 Walker A motif; other site 661367002335 ATP binding site [chemical binding]; other site 661367002336 Walker B motif; other site 661367002337 DNA binding loops [nucleotide binding] 661367002338 alanine racemase; Reviewed; Region: alr; PRK00053 661367002339 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 661367002340 active site 661367002341 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367002342 substrate binding site [chemical binding]; other site 661367002343 catalytic residues [active] 661367002344 dimer interface [polypeptide binding]; other site 661367002345 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 661367002346 DNA polymerase II large subunit DP2; Region: PolC_DP2; pfam03833 661367002347 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 661367002348 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 661367002349 metal binding site [ion binding]; metal-binding site 661367002350 dimer interface [polypeptide binding]; other site 661367002351 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 661367002352 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 661367002353 trimer interface [polypeptide binding]; other site 661367002354 active site 661367002355 substrate binding site [chemical binding]; other site 661367002356 CoA binding site [chemical binding]; other site 661367002357 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 661367002358 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 661367002359 homodimer interface [polypeptide binding]; other site 661367002360 substrate-cofactor binding pocket; other site 661367002361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367002362 catalytic residue [active] 661367002363 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 661367002364 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367002365 adenine DNA glycosylase; Provisional; Region: PRK10880 661367002366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 661367002367 minor groove reading motif; other site 661367002368 helix-hairpin-helix signature motif; other site 661367002369 substrate binding pocket [chemical binding]; other site 661367002370 active site 661367002371 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 661367002372 DNA binding and oxoG recognition site [nucleotide binding] 661367002373 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 661367002374 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 661367002375 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367002376 protein binding site [polypeptide binding]; other site 661367002377 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 661367002378 Isochorismatase family; Region: Isochorismatase; pfam00857 661367002379 dimer interface [polypeptide binding]; other site 661367002380 catalytic triad [active] 661367002381 conserved cis-peptide bond; other site 661367002382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 661367002383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002384 NAD(P) binding site [chemical binding]; other site 661367002385 active site 661367002386 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 661367002387 Cytochrome c; Region: Cytochrom_C; cl11414 661367002388 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367002389 Type III pantothenate kinase; Region: Pan_kinase; cl09130 661367002390 cell division protein MraZ; Reviewed; Region: PRK00326 661367002391 MraZ protein; Region: MraZ; pfam02381 661367002392 MraZ protein; Region: MraZ; pfam02381 661367002393 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 661367002394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002395 Septum formation initiator; Region: DivIC; cl11433 661367002396 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 661367002397 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 661367002398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367002399 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 661367002400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367002401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367002402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367002403 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 661367002404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002405 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 661367002406 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 661367002407 active site 661367002408 putative substrate binding region [chemical binding]; other site 661367002409 Amino acid permease; Region: AA_permease_2; pfam13520 661367002410 potassium transporter; Provisional; Region: PLN00149 661367002411 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 661367002412 active site 661367002413 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 661367002414 Ligand binding site [chemical binding]; other site 661367002415 Electron transfer flavoprotein domain; Region: ETF; pfam01012 661367002416 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 661367002417 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 661367002418 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 661367002419 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 661367002420 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 661367002421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002422 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 661367002423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002424 S-adenosylmethionine binding site [chemical binding]; other site 661367002425 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 661367002426 Transglycosylase; Region: Transgly; cl07896 661367002427 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367002428 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367002429 Competence protein A; Region: Competence_A; pfam11104 661367002430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002431 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 661367002432 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 661367002433 Pilus assembly protein, PilO; Region: PilO; cl01234 661367002434 Pilus assembly protein, PilP; Region: PilP; cl01235 661367002435 AMIN domain; Region: AMIN; pfam11741 661367002436 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 661367002437 Secretin and TonB N terminus short domain; Region: STN; cl06624 661367002438 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367002439 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 661367002440 shikimate kinase; Reviewed; Region: aroK; PRK00131 661367002441 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 661367002442 ADP binding site [chemical binding]; other site 661367002443 magnesium binding site [ion binding]; other site 661367002444 putative shikimate binding site; other site 661367002445 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 661367002446 active site 661367002447 dimer interface [polypeptide binding]; other site 661367002448 metal binding site [ion binding]; metal-binding site 661367002449 AAA domain; Region: AAA_22; pfam13401 661367002450 hypothetical protein; Reviewed; Region: PRK11901 661367002451 Sporulation related domain; Region: SPOR; cl10051 661367002452 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 661367002453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002454 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 661367002455 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 661367002456 active site 661367002457 dimer interface [polypeptide binding]; other site 661367002458 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 661367002459 dimer interface [polypeptide binding]; other site 661367002460 active site 661367002461 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 661367002462 active site 661367002463 tetramer interface; other site 661367002464 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 661367002465 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 661367002466 Permutation of conserved domain; other site 661367002467 active site 661367002468 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 661367002469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367002470 metal binding site [ion binding]; metal-binding site 661367002471 active site 661367002472 I-site; other site 661367002473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002474 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 661367002475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367002476 ATP binding site [chemical binding]; other site 661367002477 ATP binding site [chemical binding]; other site 661367002478 putative Mg++ binding site [ion binding]; other site 661367002479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367002480 nucleotide binding region [chemical binding]; other site 661367002481 ATP-binding site [chemical binding]; other site 661367002482 RQC domain; Region: RQC; cl09632 661367002483 HRDC domain; Region: HRDC; cl02578 661367002484 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 661367002485 active site 661367002486 DNA binding site [nucleotide binding] 661367002487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367002488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367002489 active site 661367002490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367002491 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 661367002492 substrate binding site [chemical binding]; other site 661367002493 oxyanion hole (OAH) forming residues; other site 661367002494 trimer interface [polypeptide binding]; other site 661367002495 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 661367002496 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367002497 substrate binding site [chemical binding]; other site 661367002498 oxyanion hole (OAH) forming residues; other site 661367002499 trimer interface [polypeptide binding]; other site 661367002500 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 661367002501 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 661367002502 YGGT family; Region: YGGT; cl00508 661367002503 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 661367002504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367002505 catalytic residue [active] 661367002506 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 661367002507 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 661367002508 Walker A motif; other site 661367002509 ATP binding site [chemical binding]; other site 661367002510 Walker B motif; other site 661367002511 GSCFA family; Region: GSCFA; pfam08885 661367002512 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367002513 Substrate binding site [chemical binding]; other site 661367002514 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367002515 Leucine-rich repeats; other site 661367002516 Substrate binding site [chemical binding]; other site 661367002517 ribonuclease PH; Reviewed; Region: rph; PRK00173 661367002518 Ribonuclease PH; Region: RNase_PH_bact; cd11362 661367002519 hexamer interface [polypeptide binding]; other site 661367002520 active site 661367002521 hypothetical protein; Provisional; Region: PRK11820 661367002522 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 661367002523 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 661367002524 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 661367002525 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 661367002526 catalytic site [active] 661367002527 G-X2-G-X-G-K; other site 661367002528 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 661367002529 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 661367002530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 661367002531 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 661367002532 synthetase active site [active] 661367002533 NTP binding site [chemical binding]; other site 661367002534 metal binding site [ion binding]; metal-binding site 661367002535 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 661367002536 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 661367002537 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 661367002538 homotrimer interaction site [polypeptide binding]; other site 661367002539 putative active site [active] 661367002540 ABC transporter ATPase component; Reviewed; Region: PRK11147 661367002541 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002542 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002543 ABC transporter; Region: ABC_tran_2; pfam12848 661367002544 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367002545 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 661367002546 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 661367002547 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 661367002548 NMT1/THI5 like; Region: NMT1; pfam09084 661367002549 NMT1-like family; Region: NMT1_2; cl15260 661367002550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002551 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 661367002552 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 661367002553 thiS-thiF/thiG interaction site; other site 661367002554 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 661367002555 ThiS interaction site; other site 661367002556 putative active site [active] 661367002557 tetramer interface [polypeptide binding]; other site 661367002558 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 661367002559 ATP binding site [chemical binding]; other site 661367002560 substrate binding site [chemical binding]; other site 661367002561 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 661367002562 thiamine phosphate binding site [chemical binding]; other site 661367002563 active site 661367002564 pyrophosphate binding site [ion binding]; other site 661367002565 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367002566 HSP70 interaction site [polypeptide binding]; other site 661367002567 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 661367002568 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 661367002569 iron-sulfur cluster [ion binding]; other site 661367002570 [2Fe-2S] cluster binding site [ion binding]; other site 661367002571 hypothetical protein; Provisional; Region: PRK06849 661367002572 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367002573 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 661367002574 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 661367002575 ATP binding site [chemical binding]; other site 661367002576 substrate interface [chemical binding]; other site 661367002577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367002578 active site residue [active] 661367002579 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367002580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367002581 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367002582 Preprotein translocase subunit; Region: YajC; cl00806 661367002583 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 661367002584 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 661367002585 Protein export membrane protein; Region: SecD_SecF; cl14618 661367002586 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 661367002587 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 661367002588 Protein export membrane protein; Region: SecD_SecF; cl14618 661367002589 UbiA prenyltransferase family; Region: UbiA; cl00337 661367002590 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 661367002591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002592 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 661367002593 NAD(P) binding site [chemical binding]; other site 661367002594 homodimer interface [polypeptide binding]; other site 661367002595 substrate binding site [chemical binding]; other site 661367002596 active site 661367002597 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 661367002598 dimer interface [polypeptide binding]; other site 661367002599 putative tRNA-binding site [nucleotide binding]; other site 661367002600 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 661367002601 Z1 domain; Region: Z1; pfam10593 661367002602 Fic/DOC family; Region: Fic; cl00960 661367002603 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 661367002604 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 661367002605 Domain of unknown function (DUF927); Region: DUF927; cl12098 661367002606 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 661367002607 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 661367002608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002609 Walker B; other site 661367002610 D-loop; other site 661367002611 H-loop/switch region; other site 661367002612 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 661367002613 putative active site [active] 661367002614 putative metal-binding site [ion binding]; other site 661367002615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 661367002616 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 661367002617 AAA domain; Region: AAA_13; pfam13166 661367002618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002619 ABC transporter signature motif; other site 661367002620 Walker B; other site 661367002621 D-loop; other site 661367002622 H-loop/switch region; other site 661367002623 Fic family protein [Function unknown]; Region: COG3177 661367002624 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 661367002625 Fic/DOC family; Region: Fic; cl00960 661367002626 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367002627 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367002628 DNA binding site [nucleotide binding] 661367002629 Int/Topo IB signature motif; other site 661367002630 active site 661367002631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367002632 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367002633 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367002634 DNA-binding site [nucleotide binding]; DNA binding site 661367002635 RNA-binding motif; other site 661367002636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002637 Ligand Binding Site [chemical binding]; other site 661367002638 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002639 Ligand Binding Site [chemical binding]; other site 661367002640 putative cation:proton antiport protein; Provisional; Region: PRK10669 661367002641 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367002642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002643 universal stress protein UspE; Provisional; Region: PRK11175 661367002644 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 661367002645 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367002646 Ligand Binding Site [chemical binding]; other site 661367002647 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367002648 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 661367002649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367002650 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367002651 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367002652 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367002653 Uncharacterized conserved protein [Function unknown]; Region: COG2128 661367002654 CAAX protease self-immunity; Region: Abi; cl00558 661367002655 BNR repeat-like domain; Region: BNR_2; pfam13088 661367002656 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367002657 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 661367002658 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 661367002659 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 661367002660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367002661 non-specific DNA binding site [nucleotide binding]; other site 661367002662 salt bridge; other site 661367002663 sequence-specific DNA binding site [nucleotide binding]; other site 661367002664 Cupin domain; Region: Cupin_2; cl09118 661367002665 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 661367002666 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367002667 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 661367002668 NAD(P) binding site [chemical binding]; other site 661367002669 Condensation domain; Region: Condensation; pfam00668 661367002670 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 661367002671 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 661367002672 AMP-binding enzyme; Region: AMP-binding; cl15778 661367002673 acyl-CoA synthetase; Validated; Region: PRK08308 661367002674 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002676 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002677 active site 661367002678 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 661367002679 putative NADP binding site [chemical binding]; other site 661367002680 active site 661367002681 peptide synthase; Provisional; Region: PRK12467 661367002682 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002683 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 661367002684 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367002685 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367002686 active site 661367002687 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367002688 Acyl transferase domain; Region: Acyl_transf_1; cl08282 661367002689 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002690 peptide synthase; Provisional; Region: PRK12316 661367002691 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 661367002692 AMP-binding enzyme; Region: AMP-binding; cl15778 661367002693 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002694 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 661367002695 Nonribosomal peptide synthase; Region: NRPS; pfam08415 661367002696 AMP-binding enzyme; Region: AMP-binding; cl15778 661367002697 acyl-CoA synthetase; Validated; Region: PRK08308 661367002698 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002699 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 661367002700 putative FMN binding site [chemical binding]; other site 661367002701 NADPH bind site [chemical binding]; other site 661367002702 acyl-CoA synthetase; Validated; Region: PRK05850 661367002703 AMP-binding enzyme; Region: AMP-binding; cl15778 661367002704 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367002705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 661367002706 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 661367002707 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 661367002708 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367002709 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 661367002710 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367002711 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367002712 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 661367002713 Walker A/P-loop; other site 661367002714 ATP binding site [chemical binding]; other site 661367002715 Q-loop/lid; other site 661367002716 ABC transporter signature motif; other site 661367002717 Walker B; other site 661367002718 D-loop; other site 661367002719 H-loop/switch region; other site 661367002720 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 661367002721 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367002722 Phosphotransferase enzyme family; Region: APH; pfam01636 661367002723 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 661367002724 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 661367002725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367002726 S-adenosylmethionine binding site [chemical binding]; other site 661367002727 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 661367002728 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002729 Q-loop/lid; other site 661367002730 ABC transporter signature motif; other site 661367002731 Walker B; other site 661367002732 D-loop; other site 661367002733 H-loop/switch region; other site 661367002734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002735 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367002736 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cd00159 661367002737 GTPase interaction site; other site 661367002738 catalytic residue [active] 661367002739 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 661367002740 MatE; Region: MatE; cl10513 661367002741 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 661367002742 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367002743 active site 661367002744 oxyanion hole [active] 661367002745 catalytic triad [active] 661367002746 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 661367002747 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 661367002748 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 661367002749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002750 Family description; Region: UvrD_C_2; cl15862 661367002751 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367002752 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367002753 Leucine carboxyl methyltransferase; Region: LCM; cl01306 661367002754 Domain of unknown function DUF87; Region: DUF87; pfam01935 661367002755 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 661367002756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002757 Domain of unknown function (DUF305); Region: DUF305; cl15795 661367002758 Ferritin-like domain; Region: Ferritin; pfam00210 661367002759 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 661367002760 dinuclear metal binding motif [ion binding]; other site 661367002761 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 661367002762 nucleotide binding site [chemical binding]; other site 661367002763 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 661367002764 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367002765 active site 661367002766 cyclase homology domain; Region: CHD; cd07302 661367002767 nucleotidyl binding site; other site 661367002768 metal binding site [ion binding]; metal-binding site 661367002769 dimer interface [polypeptide binding]; other site 661367002770 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 661367002771 catalytic core [active] 661367002772 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 661367002773 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 661367002774 active site 661367002775 Zn binding site [ion binding]; other site 661367002776 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 661367002777 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367002778 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 661367002779 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 661367002780 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 661367002781 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367002782 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 661367002783 substrate binding site [chemical binding]; other site 661367002784 multimerization interface [polypeptide binding]; other site 661367002785 ATP binding site [chemical binding]; other site 661367002786 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 661367002787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367002788 FeS/SAM binding site; other site 661367002789 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 661367002790 CoenzymeA binding site [chemical binding]; other site 661367002791 subunit interaction site [polypeptide binding]; other site 661367002792 PHB binding site; other site 661367002793 Acylphosphatase; Region: Acylphosphatase; cl00551 661367002794 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367002795 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 661367002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367002797 putative substrate translocation pore; other site 661367002798 Protein of unknown function (DUF520); Region: DUF520; cl00723 661367002799 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 661367002800 Peptidase family M48; Region: Peptidase_M48; cl12018 661367002801 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 661367002802 catalytic motif [active] 661367002803 Zn binding site [ion binding]; other site 661367002804 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 661367002805 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 661367002806 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 661367002807 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 661367002808 dimerization interface [polypeptide binding]; other site 661367002809 active site 661367002810 CTP synthetase; Validated; Region: pyrG; PRK05380 661367002811 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 661367002812 Catalytic site [active] 661367002813 active site 661367002814 UTP binding site [chemical binding]; other site 661367002815 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 661367002816 active site 661367002817 putative oxyanion hole; other site 661367002818 catalytic triad [active] 661367002819 NeuB family; Region: NeuB; cl00496 661367002820 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 661367002821 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002822 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367002823 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367002824 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367002825 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 661367002826 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 661367002827 NAD binding site [chemical binding]; other site 661367002828 homotetramer interface [polypeptide binding]; other site 661367002829 homodimer interface [polypeptide binding]; other site 661367002830 substrate binding site [chemical binding]; other site 661367002831 active site 661367002832 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 661367002833 Sugar specificity; other site 661367002834 Pyrimidine base specificity; other site 661367002835 ATP-binding site [chemical binding]; other site 661367002836 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 661367002837 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367002838 active site residue [active] 661367002839 Glutamate-cysteine ligase; Region: GshA; pfam08886 661367002840 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 661367002841 glutathione synthetase; Provisional; Region: PRK05246 661367002842 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 661367002843 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367002844 VacJ like lipoprotein; Region: VacJ; cl01073 661367002845 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 661367002846 putative active site [active] 661367002847 dimerization interface [polypeptide binding]; other site 661367002848 putative tRNAtyr binding site [nucleotide binding]; other site 661367002849 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 661367002850 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 661367002851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002852 Family description; Region: UvrD_C_2; cl15862 661367002853 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 661367002854 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 661367002855 catalytic residues [active] 661367002856 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 661367002857 dimer interface [polypeptide binding]; other site 661367002858 motif 1; other site 661367002859 active site 661367002860 motif 2; other site 661367002861 motif 3; other site 661367002862 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 661367002863 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 661367002864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002865 regulatory protein UhpC; Provisional; Region: PRK11663 661367002866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367002867 putative substrate translocation pore; other site 661367002868 NMT1-like family; Region: NMT1_2; cl15260 661367002869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367002870 dimer interface [polypeptide binding]; other site 661367002871 conserved gate region; other site 661367002872 ABC-ATPase subunit interface; other site 661367002873 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 661367002874 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 661367002875 Walker A/P-loop; other site 661367002876 ATP binding site [chemical binding]; other site 661367002877 Q-loop/lid; other site 661367002878 ABC transporter signature motif; other site 661367002879 Walker B; other site 661367002880 D-loop; other site 661367002881 H-loop/switch region; other site 661367002882 NIL domain; Region: NIL; cl09633 661367002883 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 661367002884 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 661367002885 AMP-binding enzyme; Region: AMP-binding; cl15778 661367002886 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367002887 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 661367002888 active site 661367002889 catalytic residues [active] 661367002890 metal binding site [ion binding]; metal-binding site 661367002891 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 661367002892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367002893 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367002894 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 661367002895 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 661367002896 carboxyltransferase (CT) interaction site; other site 661367002897 biotinylation site [posttranslational modification]; other site 661367002898 enoyl-CoA hydratase; Provisional; Region: PRK05995 661367002899 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367002900 substrate binding site [chemical binding]; other site 661367002901 oxyanion hole (OAH) forming residues; other site 661367002902 trimer interface [polypeptide binding]; other site 661367002903 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 661367002904 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367002905 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367002906 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 661367002907 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367002908 dimer interface [polypeptide binding]; other site 661367002909 active site 661367002910 isovaleryl-CoA dehydrogenase; Region: PLN02519 661367002911 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 661367002912 substrate binding site [chemical binding]; other site 661367002913 FAD binding site [chemical binding]; other site 661367002914 catalytic base [active] 661367002915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002916 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 661367002917 quinone interaction residues [chemical binding]; other site 661367002918 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 661367002919 active site 661367002920 catalytic residues [active] 661367002921 FMN binding site [chemical binding]; other site 661367002922 substrate binding site [chemical binding]; other site 661367002923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367002924 Coenzyme A binding pocket [chemical binding]; other site 661367002925 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 661367002926 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367002927 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 661367002928 Walker A/P-loop; other site 661367002929 ATP binding site [chemical binding]; other site 661367002930 Q-loop/lid; other site 661367002931 ABC transporter signature motif; other site 661367002932 Walker B; other site 661367002933 D-loop; other site 661367002934 H-loop/switch region; other site 661367002935 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 661367002936 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 661367002937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367002938 putative substrate translocation pore; other site 661367002939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367002940 oligomerization interface [polypeptide binding]; other site 661367002941 active site 661367002942 NAD+ binding site [chemical binding]; other site 661367002943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367002944 Helix-turn-helix domains; Region: HTH; cl00088 661367002945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367002946 dimerization interface [polypeptide binding]; other site 661367002947 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 661367002948 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 661367002949 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 661367002950 Walker A motif; other site 661367002951 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 661367002952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367002953 putative recombination protein RecB; Provisional; Region: PRK13909 661367002954 Family description; Region: UvrD_C_2; cl15862 661367002955 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 661367002956 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 661367002957 nucleotide binding site [chemical binding]; other site 661367002958 substrate binding site [chemical binding]; other site 661367002959 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 661367002960 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 661367002961 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 661367002962 active site 661367002963 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367002964 substrate binding site [chemical binding]; other site 661367002965 catalytic residues [active] 661367002966 dimer interface [polypeptide binding]; other site 661367002967 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367002968 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367002969 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367002970 putative active site [active] 661367002971 putative NTP binding site [chemical binding]; other site 661367002972 putative nucleic acid binding site [nucleotide binding]; other site 661367002973 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 661367002974 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 661367002975 dimer interface [polypeptide binding]; other site 661367002976 active site 661367002977 Schiff base residues; other site 661367002978 Family of unknown function (DUF490); Region: DUF490; pfam04357 661367002979 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 661367002980 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 661367002981 Surface antigen; Region: Bac_surface_Ag; cl03097 661367002982 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 661367002983 MutS domain I; Region: MutS_I; pfam01624 661367002984 MutS domain II; Region: MutS_II; pfam05188 661367002985 MutS family domain IV; Region: MutS_IV; pfam05190 661367002986 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 661367002987 Walker A/P-loop; other site 661367002988 ATP binding site [chemical binding]; other site 661367002989 Q-loop/lid; other site 661367002990 ABC transporter signature motif; other site 661367002991 Walker B; other site 661367002992 D-loop; other site 661367002993 H-loop/switch region; other site 661367002994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367002995 dimer interface [polypeptide binding]; other site 661367002996 phosphorylation site [posttranslational modification] 661367002997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367002998 ATP binding site [chemical binding]; other site 661367002999 G-X-G motif; other site 661367003000 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 661367003001 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 661367003002 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367003003 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 661367003004 NAD(P) binding site [chemical binding]; other site 661367003005 catalytic residues [active] 661367003006 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 661367003007 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 661367003008 putative active site [active] 661367003009 metal binding site [ion binding]; metal-binding site 661367003010 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 661367003011 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 661367003012 catalytic triad [active] 661367003013 Competence-damaged protein; Region: CinA; cl00666 661367003014 recombinase A; Provisional; Region: recA; PRK09354 661367003015 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 661367003016 hexamer interface [polypeptide binding]; other site 661367003017 Walker A motif; other site 661367003018 ATP binding site [chemical binding]; other site 661367003019 Walker B motif; other site 661367003020 RecX family; Region: RecX; cl00936 661367003021 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 661367003022 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 661367003023 motif 1; other site 661367003024 active site 661367003025 motif 2; other site 661367003026 motif 3; other site 661367003027 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 661367003028 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 661367003029 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 661367003030 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 661367003031 conserved cys residue [active] 661367003032 Zeta toxin; Region: Zeta_toxin; pfam06414 661367003033 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 661367003034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003035 NAD(P) binding site [chemical binding]; other site 661367003036 active site 661367003037 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 661367003038 FAD binding domain; Region: FAD_binding_4; pfam01565 661367003039 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 661367003040 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 661367003041 P-loop; other site 661367003042 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 661367003043 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 661367003044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367003045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367003046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367003047 DNA binding residues [nucleotide binding] 661367003048 peptide chain release factor 2; Validated; Region: prfB; PRK00578 661367003049 RF-1 domain; Region: RF-1; cl02875 661367003050 RF-1 domain; Region: RF-1; cl02875 661367003051 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 661367003052 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 661367003053 dimer interface [polypeptide binding]; other site 661367003054 putative anticodon binding site; other site 661367003055 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 661367003056 motif 1; other site 661367003057 active site 661367003058 motif 2; other site 661367003059 motif 3; other site 661367003060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367003061 Helix-turn-helix domains; Region: HTH; cl00088 661367003062 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 661367003063 substrate binding pocket [chemical binding]; other site 661367003064 dimerization interface [polypeptide binding]; other site 661367003065 Protein kinase domain; Region: Pkinase; pfam00069 661367003066 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367003067 active site 661367003068 ATP binding site [chemical binding]; other site 661367003069 substrate binding site [chemical binding]; other site 661367003070 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367003071 substrate binding site [chemical binding]; other site 661367003072 activation loop (A-loop); other site 661367003073 activation loop (A-loop); other site 661367003074 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 661367003075 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 661367003076 active site 661367003077 zinc binding site [ion binding]; other site 661367003078 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 661367003079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367003080 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367003081 active site 661367003082 metal binding site [ion binding]; metal-binding site 661367003083 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003084 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003085 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367003087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003088 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 661367003089 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 661367003090 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 661367003091 malate dehydrogenase; Provisional; Region: PRK13529 661367003092 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367003093 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 661367003094 NAD(P) binding site [chemical binding]; other site 661367003095 Survival protein SurE; Region: SurE; cl00448 661367003096 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 661367003097 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 661367003098 putative peptidoglycan binding site; other site 661367003099 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 661367003100 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367003101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367003102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367003103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367003104 DNA binding residues [nucleotide binding] 661367003105 VirK protein; Region: VirK; pfam06903 661367003106 Cupin domain; Region: Cupin_2; cl09118 661367003107 Transcriptional regulator; Region: Transcrip_reg; cl00361 661367003108 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 661367003109 active site 661367003110 putative DNA-binding cleft [nucleotide binding]; other site 661367003111 dimer interface [polypeptide binding]; other site 661367003112 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 661367003113 RuvA N terminal domain; Region: RuvA_N; pfam01330 661367003114 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 661367003115 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 661367003116 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367003117 sensor protein QseC; Provisional; Region: PRK10337 661367003118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367003119 dimer interface [polypeptide binding]; other site 661367003120 phosphorylation site [posttranslational modification] 661367003121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003122 ATP binding site [chemical binding]; other site 661367003123 Mg2+ binding site [ion binding]; other site 661367003124 G-X-G motif; other site 661367003125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003126 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 661367003127 active site 661367003128 phosphorylation site [posttranslational modification] 661367003129 intermolecular recognition site; other site 661367003130 dimerization interface [polypeptide binding]; other site 661367003131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367003132 DNA binding site [nucleotide binding] 661367003133 Intracellular septation protein A; Region: IspA; cl01098 661367003134 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 661367003135 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367003136 catalytic residue [active] 661367003137 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 661367003138 putative peptidoglycan binding site; other site 661367003139 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 661367003140 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 661367003141 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 661367003142 putative peptidoglycan binding site; other site 661367003143 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367003144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367003145 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 661367003146 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 661367003147 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 661367003148 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 661367003149 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 661367003150 homodimer interface [polypeptide binding]; other site 661367003151 NADP binding site [chemical binding]; other site 661367003152 substrate binding site [chemical binding]; other site 661367003153 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 661367003154 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 661367003155 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 661367003156 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 661367003157 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003158 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003159 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003160 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003161 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367003162 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367003163 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 661367003164 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 661367003165 dimerization interface 3.5A [polypeptide binding]; other site 661367003166 active site 661367003167 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 661367003168 active site 661367003169 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 661367003170 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 661367003171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003172 catalytic residue [active] 661367003173 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 661367003174 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 661367003175 substrate binding site [chemical binding]; other site 661367003176 active site 661367003177 catalytic residues [active] 661367003178 heterodimer interface [polypeptide binding]; other site 661367003179 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 661367003180 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367003181 active site 661367003182 HIGH motif; other site 661367003183 nucleotide binding site [chemical binding]; other site 661367003184 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 661367003185 KMSKS motif; other site 661367003186 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 661367003187 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 661367003188 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 661367003189 active site 661367003190 HIGH motif; other site 661367003191 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 661367003192 KMSKS motif; other site 661367003193 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 661367003194 tRNA binding surface [nucleotide binding]; other site 661367003195 anticodon binding site; other site 661367003196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003197 putative substrate translocation pore; other site 661367003198 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 661367003199 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 661367003200 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367003201 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367003202 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367003203 GIY-YIG motif/motif A; other site 661367003204 putative active site [active] 661367003205 putative metal binding site [ion binding]; other site 661367003206 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 661367003207 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 661367003208 Walker A motif; other site 661367003209 ATP binding site [chemical binding]; other site 661367003210 Walker B motif; other site 661367003211 Sporulation related domain; Region: SPOR; cl10051 661367003212 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 661367003213 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003214 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003215 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 661367003216 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 661367003217 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 661367003218 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367003219 MutS2 family protein; Region: mutS2; TIGR01069 661367003220 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367003221 HSP70 interaction site [polypeptide binding]; other site 661367003222 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 661367003223 putative FMN binding site [chemical binding]; other site 661367003224 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 661367003225 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 661367003226 GAF domain; Region: GAF; cl15785 661367003227 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 661367003228 GAF domain; Region: GAF; cl15785 661367003229 PAS domain; Region: PAS_9; pfam13426 661367003230 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367003231 cyclase homology domain; Region: CHD; cd07302 661367003232 nucleotidyl binding site; other site 661367003233 metal binding site [ion binding]; metal-binding site 661367003234 dimer interface [polypeptide binding]; other site 661367003235 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 661367003236 Helix-turn-helix domains; Region: HTH; cl00088 661367003237 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 661367003238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367003239 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367003240 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 661367003241 DNA binding residues [nucleotide binding] 661367003242 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 661367003243 dimer interface [polypeptide binding]; other site 661367003244 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 661367003245 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 661367003246 active site 661367003247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 661367003248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003249 Coenzyme A binding pocket [chemical binding]; other site 661367003250 CoA-transferase family III; Region: CoA_transf_3; pfam02515 661367003251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003252 Coenzyme A binding pocket [chemical binding]; other site 661367003253 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367003254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367003255 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 661367003256 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367003257 ABC transporter; Region: ABC_tran_2; pfam12848 661367003258 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 661367003259 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367003260 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367003261 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003263 Walker A/P-loop; other site 661367003264 ATP binding site [chemical binding]; other site 661367003265 Q-loop/lid; other site 661367003266 ABC transporter signature motif; other site 661367003267 Walker B; other site 661367003268 D-loop; other site 661367003269 H-loop/switch region; other site 661367003270 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 661367003271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367003272 Coenzyme A binding pocket [chemical binding]; other site 661367003273 Helix-turn-helix domains; Region: HTH; cl00088 661367003274 WYL domain; Region: WYL; cl14852 661367003275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 661367003276 putative dimer interface [polypeptide binding]; other site 661367003277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367003278 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 661367003279 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 661367003280 putative active site [active] 661367003281 putative substrate binding site [chemical binding]; other site 661367003282 ATP binding site [chemical binding]; other site 661367003283 Phosphotransferase enzyme family; Region: APH; pfam01636 661367003284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003285 S-adenosylmethionine binding site [chemical binding]; other site 661367003286 Cache domain; Region: Cache_1; pfam02743 661367003287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367003288 cyclase homology domain; Region: CHD; cd07302 661367003289 nucleotidyl binding site; other site 661367003290 metal binding site [ion binding]; metal-binding site 661367003291 dimer interface [polypeptide binding]; other site 661367003292 Spore germination protein; Region: Spore_permease; cl15802 661367003293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367003294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367003295 substrate binding pocket [chemical binding]; other site 661367003296 membrane-bound complex binding site; other site 661367003297 hinge residues; other site 661367003298 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 661367003299 PilZ domain; Region: PilZ; cl01260 661367003300 Ferredoxin [Energy production and conversion]; Region: COG1146 661367003301 4Fe-4S binding domain; Region: Fer4; cl02805 661367003302 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 661367003303 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 661367003304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003305 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003306 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 661367003307 Trm112p-like protein; Region: Trm112p; cl01066 661367003308 Transposase domain (DUF772); Region: DUF772; cl15789 661367003309 Transposase domain (DUF772); Region: DUF772; cl15789 661367003310 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367003311 BolA-like protein; Region: BolA; cl00386 661367003312 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 661367003313 Pilin (bacterial filament); Region: Pilin; pfam00114 661367003314 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 661367003315 active site 661367003316 ADP/pyrophosphate binding site [chemical binding]; other site 661367003317 dimerization interface [polypeptide binding]; other site 661367003318 allosteric effector site; other site 661367003319 fructose-1,6-bisphosphate binding site; other site 661367003320 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 661367003321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367003322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367003323 dimer interface [polypeptide binding]; other site 661367003324 phosphorylation site [posttranslational modification] 661367003325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003326 ATP binding site [chemical binding]; other site 661367003327 Mg2+ binding site [ion binding]; other site 661367003328 G-X-G motif; other site 661367003329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 661367003330 active site 661367003331 phosphorylation site [posttranslational modification] 661367003332 dimerization interface [polypeptide binding]; other site 661367003333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003334 active site 661367003335 phosphorylation site [posttranslational modification] 661367003336 intermolecular recognition site; other site 661367003337 dimerization interface [polypeptide binding]; other site 661367003338 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367003339 putative binding surface; other site 661367003340 active site 661367003341 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 661367003342 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 661367003343 HIGH motif; other site 661367003344 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 661367003345 active site 661367003346 KMSKS motif; other site 661367003347 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 661367003348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367003349 glutathionine S-transferase; Provisional; Region: PRK10542 661367003350 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 661367003351 C-terminal domain interface [polypeptide binding]; other site 661367003352 GSH binding site (G-site) [chemical binding]; other site 661367003353 dimer interface [polypeptide binding]; other site 661367003354 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 661367003355 dimer interface [polypeptide binding]; other site 661367003356 N-terminal domain interface [polypeptide binding]; other site 661367003357 substrate binding pocket (H-site) [chemical binding]; other site 661367003358 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 661367003359 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 661367003360 Protein of unknown function, DUF462; Region: DUF462; cl01190 661367003361 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367003362 catalytic site [active] 661367003363 metal binding site [ion binding]; metal-binding site 661367003364 GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl02218 661367003365 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 661367003366 Uncharacterized conserved protein [Function unknown]; Region: COG2850 661367003367 JmjC domain, hydroxylase; Region: JmjC; cl15814 661367003368 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 661367003369 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367003370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003371 hypothetical protein; Provisional; Region: PRK01617 661367003372 SEC-C motif; Region: SEC-C; pfam02810 661367003373 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 661367003374 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 661367003375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367003376 active site 661367003377 phosphorylation site [posttranslational modification] 661367003378 intermolecular recognition site; other site 661367003379 dimerization interface [polypeptide binding]; other site 661367003380 PAS domain S-box; Region: sensory_box; TIGR00229 661367003381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367003382 metal binding site [ion binding]; metal-binding site 661367003383 active site 661367003384 I-site; other site 661367003385 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367003386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367003387 PAS domain; Region: PAS_9; pfam13426 661367003388 putative active site [active] 661367003389 heme pocket [chemical binding]; other site 661367003390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367003391 ATP binding site [chemical binding]; other site 661367003392 Mg2+ binding site [ion binding]; other site 661367003393 G-X-G motif; other site 661367003394 Uncharacterized conserved protein [Function unknown]; Region: COG3287 661367003395 FIST N domain; Region: FIST; cl10701 661367003396 FIST C domain; Region: FIST_C; pfam10442 661367003397 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 661367003398 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367003399 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367003400 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 661367003401 Protein export membrane protein; Region: SecD_SecF; cl14618 661367003402 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 661367003403 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367003404 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 661367003405 active site 661367003406 homopentamer interface [polypeptide binding]; other site 661367003407 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 661367003408 active site 661367003409 homopentamer interface [polypeptide binding]; other site 661367003410 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 661367003411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367003412 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367003413 substrate binding pocket [chemical binding]; other site 661367003414 membrane-bound complex binding site; other site 661367003415 hinge residues; other site 661367003416 Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653 661367003417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003418 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367003419 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 661367003420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 661367003421 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 661367003422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 661367003423 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 661367003424 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 661367003425 GspL periplasmic domain; Region: GspL_C; cl14909 661367003426 Transglycosylase SLT domain; Region: SLT_2; pfam13406 661367003427 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 661367003428 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367003429 GTP-binding protein LepA; Provisional; Region: PRK05433 661367003430 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 661367003431 G1 box; other site 661367003432 putative GEF interaction site [polypeptide binding]; other site 661367003433 GTP/Mg2+ binding site [chemical binding]; other site 661367003434 Switch I region; other site 661367003435 G2 box; other site 661367003436 G3 box; other site 661367003437 Switch II region; other site 661367003438 G4 box; other site 661367003439 G5 box; other site 661367003440 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 661367003441 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 661367003442 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 661367003443 signal peptidase I; Provisional; Region: PRK10861 661367003444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 661367003445 Catalytic site [active] 661367003446 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 661367003447 ribonuclease III; Reviewed; Region: rnc; PRK00102 661367003448 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 661367003449 dimerization interface [polypeptide binding]; other site 661367003450 active site 661367003451 metal binding site [ion binding]; metal-binding site 661367003452 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 661367003453 dsRNA binding site [nucleotide binding]; other site 661367003454 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 661367003455 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367003456 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367003457 ABC transporter; Region: ABC_tran_2; pfam12848 661367003458 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367003459 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367003460 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 661367003461 Int/Topo IB signature motif; other site 661367003462 trigger factor; Provisional; Region: tig; PRK01490 661367003463 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 661367003464 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 661367003465 Clp protease; Region: CLP_protease; pfam00574 661367003466 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 661367003467 oligomer interface [polypeptide binding]; other site 661367003468 active site residues [active] 661367003469 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 661367003470 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 661367003471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367003472 Walker A motif; other site 661367003473 ATP binding site [chemical binding]; other site 661367003474 Walker B motif; other site 661367003475 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 661367003476 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 661367003477 Found in ATP-dependent protease La (LON); Region: LON; smart00464 661367003478 Found in ATP-dependent protease La (LON); Region: LON; smart00464 661367003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367003480 Walker A motif; other site 661367003481 ATP binding site [chemical binding]; other site 661367003482 Walker B motif; other site 661367003483 arginine finger; other site 661367003484 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 661367003485 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367003486 IHF dimer interface [polypeptide binding]; other site 661367003487 IHF - DNA interface [nucleotide binding]; other site 661367003488 periplasmic folding chaperone; Provisional; Region: PRK10788 661367003489 SurA N-terminal domain; Region: SurA_N_3; cl07813 661367003490 PPIC-type PPIASE domain; Region: Rotamase; cl08278 661367003491 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 661367003492 Outer membrane lipoprotein; Region: YfiO; pfam13525 661367003493 Putative exonuclease, RdgC; Region: RdgC; cl01122 661367003494 K+ potassium transporter; Region: K_trans; cl15781 661367003495 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 661367003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003497 S-adenosylmethionine binding site [chemical binding]; other site 661367003498 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 661367003499 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 661367003500 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 661367003501 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 661367003502 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 661367003503 substrate binding site [chemical binding]; other site 661367003504 glutamase interaction surface [polypeptide binding]; other site 661367003505 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 661367003506 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 661367003507 catalytic residues [active] 661367003508 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 661367003509 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 661367003510 putative active site [active] 661367003511 oxyanion strand; other site 661367003512 catalytic triad [active] 661367003513 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 661367003514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367003515 active site 661367003516 motif I; other site 661367003517 motif II; other site 661367003518 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 661367003519 putative active site pocket [active] 661367003520 4-fold oligomerization interface [polypeptide binding]; other site 661367003521 metal binding residues [ion binding]; metal-binding site 661367003522 3-fold/trimer interface [polypeptide binding]; other site 661367003523 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 661367003524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003526 homodimer interface [polypeptide binding]; other site 661367003527 catalytic residue [active] 661367003528 histidinol dehydrogenase; Region: hisD; TIGR00069 661367003529 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 661367003530 NAD binding site [chemical binding]; other site 661367003531 dimerization interface [polypeptide binding]; other site 661367003532 product binding site; other site 661367003533 substrate binding site [chemical binding]; other site 661367003534 zinc binding site [ion binding]; other site 661367003535 catalytic residues [active] 661367003536 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 661367003537 ATP phosphoribosyltransferase; Region: HisG; cl15266 661367003538 HisG, C-terminal domain; Region: HisG_C; cl06867 661367003539 Helix-turn-helix domains; Region: HTH; cl00088 661367003540 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 661367003541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367003542 active site 661367003543 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367003544 DNA-binding site [nucleotide binding]; DNA binding site 661367003545 RNA-binding motif; other site 661367003546 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 661367003547 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 661367003548 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 661367003549 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 661367003550 putative active site [active] 661367003551 putative metal binding site [ion binding]; other site 661367003552 Acyl transferase domain; Region: Acyl_transf_1; cl08282 661367003553 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367003554 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367003555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003557 putative substrate translocation pore; other site 661367003558 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 661367003559 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 661367003560 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 661367003561 FlgD Ig-like domain; Region: FlgD_ig; cl15790 661367003562 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 661367003563 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 661367003564 active site 661367003565 catalytic site [active] 661367003566 tetramer interface [polypeptide binding]; other site 661367003567 GCN5-related N-acetyltransferases (GNAT) represent a large superfamily of functionally diverse enzymes that catalyze the transfer of an acetyl group from acetyl-Coenzyme A to the primary amine of a wide range of acceptor substrates. Members of this...; Region: GNAT; cl00443 661367003568 Coenzyme A binding pocket; other site 661367003569 Phospholipid methyltransferase; Region: PEMT; cl00763 661367003570 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367003571 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 661367003572 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 661367003573 PhnA protein; Region: PhnA; pfam03831 661367003574 aspartate aminotransferase; Provisional; Region: PRK05764 661367003575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003577 homodimer interface [polypeptide binding]; other site 661367003578 catalytic residue [active] 661367003579 Chorismate mutase type II; Region: CM_2; cl00693 661367003580 Prephenate dehydratase; Region: PDT; pfam00800 661367003581 NeuB family; Region: NeuB; cl00496 661367003582 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 661367003583 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 661367003584 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367003585 ATP binding site [chemical binding]; other site 661367003586 Mg++ binding site [ion binding]; other site 661367003587 motif III; other site 661367003588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367003589 nucleotide binding region [chemical binding]; other site 661367003590 ATP-binding site [chemical binding]; other site 661367003591 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 661367003592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367003593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367003594 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 661367003595 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 661367003596 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 661367003597 generic binding surface II; other site 661367003598 generic binding surface I; other site 661367003599 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 661367003600 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 661367003601 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 661367003602 aromatic arch; other site 661367003603 DCoH dimer interaction site [polypeptide binding]; other site 661367003604 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 661367003605 DCoH tetramer interaction site [polypeptide binding]; other site 661367003606 substrate binding site [chemical binding]; other site 661367003607 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 661367003608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367003609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367003610 homodimer interface [polypeptide binding]; other site 661367003611 catalytic residue [active] 661367003612 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 661367003613 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 661367003614 MltA specific insert domain; Region: MltA; cl08398 661367003615 3D domain; Region: 3D; cl01439 661367003616 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367003617 NodB motif; other site 661367003618 putative active site [active] 661367003619 putative catalytic site [active] 661367003620 putative Zn binding site [ion binding]; other site 661367003621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003622 putative substrate translocation pore; other site 661367003623 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 661367003624 substrate binding pocket [chemical binding]; other site 661367003625 catalytic residues [active] 661367003626 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 661367003627 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 661367003628 tetramer interface [polypeptide binding]; other site 661367003629 heme binding pocket [chemical binding]; other site 661367003630 NADPH binding site [chemical binding]; other site 661367003631 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367003632 active site clefts [active] 661367003633 zinc binding site [ion binding]; other site 661367003634 dimer interface [polypeptide binding]; other site 661367003635 pyruvate dehydrogenase; Provisional; Region: PRK09124 661367003636 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 661367003637 PYR/PP interface [polypeptide binding]; other site 661367003638 tetramer interface [polypeptide binding]; other site 661367003639 dimer interface [polypeptide binding]; other site 661367003640 TPP binding site [chemical binding]; other site 661367003641 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 661367003642 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 661367003643 TPP-binding site [chemical binding]; other site 661367003644 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367003645 Uncharacterized conserved protein [Function unknown]; Region: COG4278 661367003646 Helix-turn-helix domains; Region: HTH; cl00088 661367003647 multidrug efflux protein; Reviewed; Region: PRK01766 661367003648 MatE; Region: MatE; cl10513 661367003649 MatE; Region: MatE; cl10513 661367003650 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003651 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003652 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003653 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367003654 cyanophycin synthetase; Provisional; Region: PRK14016 661367003655 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 661367003656 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 661367003657 Ligand Binding Site [chemical binding]; other site 661367003658 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367003659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367003660 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 661367003661 active site 661367003662 HIGH motif; other site 661367003663 nucleotide binding site [chemical binding]; other site 661367003664 MASE1; Region: MASE1; pfam05231 661367003665 CHASE domain; Region: CHASE; cl01369 661367003666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 661367003667 PAS domain; Region: PAS_9; pfam13426 661367003668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367003669 metal binding site [ion binding]; metal-binding site 661367003670 active site 661367003671 I-site; other site 661367003672 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 661367003673 mce related protein; Region: MCE; pfam02470 661367003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 661367003675 Protein of unknown function (DUF330); Region: DUF330; cl01135 661367003676 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 661367003677 active site 661367003678 catalytic residues [active] 661367003679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003680 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 661367003681 GIY-YIG motif/motif A; other site 661367003682 putative active site [active] 661367003683 putative metal binding site [ion binding]; other site 661367003684 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 661367003685 diiron binding motif [ion binding]; other site 661367003686 tellurite resistance protein TehB; Provisional; Region: PRK12335 661367003687 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 661367003688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003689 S-adenosylmethionine binding site [chemical binding]; other site 661367003690 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 661367003691 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 661367003692 Low-spin heme binding site [chemical binding]; other site 661367003693 Putative water exit pathway; other site 661367003694 Binuclear center (active site) [active] 661367003695 K-pathway; other site 661367003696 Putative proton exit pathway; other site 661367003697 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367003698 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367003699 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 661367003700 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 661367003701 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 661367003702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367003703 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003704 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367003705 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367003706 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 661367003707 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 661367003708 catalytic triad [active] 661367003709 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 661367003710 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 661367003711 active site/putative ARF binding site [active] 661367003712 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367003713 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367003714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367003715 catalytic residue [active] 661367003716 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 661367003717 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 661367003718 maturation of RBCL 1; Provisional; Region: PLN03218 661367003719 PPR repeat family; Region: PPR_2; pfam13041 661367003720 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 661367003721 putative catalytic site [active] 661367003722 putative metal binding site [ion binding]; other site 661367003723 putative phosphate binding site [ion binding]; other site 661367003724 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 661367003725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003726 S-adenosylmethionine binding site [chemical binding]; other site 661367003727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003728 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367003729 putative substrate translocation pore; other site 661367003730 Conserved TM helix; Region: TM_helix; pfam05552 661367003731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367003732 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 661367003733 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367003734 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 661367003735 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367003736 HSP70 interaction site [polypeptide binding]; other site 661367003737 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 661367003738 Helix-turn-helix domains; Region: HTH; cl00088 661367003739 Double zinc ribbon; Region: DZR; pfam12773 661367003740 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003741 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367003742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003743 Walker A/P-loop; other site 661367003744 ATP binding site [chemical binding]; other site 661367003745 Q-loop/lid; other site 661367003746 ABC transporter signature motif; other site 661367003747 Walker B; other site 661367003748 D-loop; other site 661367003749 H-loop/switch region; other site 661367003750 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 661367003751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003752 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367003753 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 661367003754 putative di-iron ligands [ion binding]; other site 661367003755 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 661367003756 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367003757 ligand binding site [chemical binding]; other site 661367003758 flexible hinge region; other site 661367003759 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 661367003760 putative switch regulator; other site 661367003761 non-specific DNA interactions [nucleotide binding]; other site 661367003762 DNA binding site [nucleotide binding] 661367003763 sequence specific DNA binding site [nucleotide binding]; other site 661367003764 putative cAMP binding site [chemical binding]; other site 661367003765 short chain dehydrogenase; Provisional; Region: PRK12827 661367003766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003767 NAD(P) binding site [chemical binding]; other site 661367003768 active site 661367003769 MoxR-like ATPases [General function prediction only]; Region: COG0714 661367003770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367003771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003772 Walker A/P-loop; other site 661367003773 ATP binding site [chemical binding]; other site 661367003774 Q-loop/lid; other site 661367003775 ABC transporter signature motif; other site 661367003776 Walker B; other site 661367003777 D-loop; other site 661367003778 H-loop/switch region; other site 661367003779 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 661367003780 dimer interface [polypeptide binding]; other site 661367003781 putative radical transfer pathway; other site 661367003782 diiron center [ion binding]; other site 661367003783 tyrosyl radical; other site 661367003784 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 661367003785 ATP cone domain; Region: ATP-cone; pfam03477 661367003786 ATP cone domain; Region: ATP-cone; pfam03477 661367003787 Class I ribonucleotide reductase; Region: RNR_I; cd01679 661367003788 active site 661367003789 dimer interface [polypeptide binding]; other site 661367003790 catalytic residues [active] 661367003791 effector binding site; other site 661367003792 R2 peptide binding site; other site 661367003793 Predicted periplasmic protein [Function unknown]; Region: COG3698 661367003794 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 661367003795 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 661367003796 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 661367003797 Sel1 repeat; Region: Sel1; cl02723 661367003798 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367003799 Sel1 repeat; Region: Sel1; cl02723 661367003800 Sel1 repeat; Region: Sel1; cl02723 661367003801 Sel1 repeat; Region: Sel1; cl02723 661367003802 Sel1 repeat; Region: Sel1; cl02723 661367003803 Sel1 repeat; Region: Sel1; cl02723 661367003804 Sel1 repeat; Region: Sel1; cl02723 661367003805 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 661367003806 general secretion pathway protein J; Region: gspJ; TIGR01711 661367003807 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 661367003808 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 661367003809 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367003810 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 661367003811 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 661367003812 general secretion pathway protein F; Region: GspF; TIGR02120 661367003813 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 661367003814 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 661367003815 glutamine synthetase; Provisional; Region: glnA; PRK09469 661367003816 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 661367003817 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 661367003818 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 661367003819 Protein of unknown function (DUF328); Region: DUF328; cl01143 661367003820 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 661367003821 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 661367003822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367003823 catalytic residue [active] 661367003824 heat shock protein 90; Provisional; Region: PRK05218 661367003825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 661367003826 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 661367003828 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367003829 Helix-turn-helix domains; Region: HTH; cl00088 661367003830 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 661367003831 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 661367003832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003834 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 661367003835 RNA/DNA hybrid binding site [nucleotide binding]; other site 661367003836 active site 661367003837 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 661367003838 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 661367003839 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 661367003840 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367003841 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 661367003842 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 661367003843 Oligomerisation domain; Region: Oligomerisation; cl00519 661367003844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367003845 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 661367003846 urocanate hydratase; Provisional; Region: PRK05414 661367003847 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 661367003848 active sites [active] 661367003849 tetramer interface [polypeptide binding]; other site 661367003850 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 661367003851 RNA/DNA hybrid binding site [nucleotide binding]; other site 661367003852 active site 661367003853 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 661367003854 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 661367003855 active site 661367003856 substrate binding site [chemical binding]; other site 661367003857 catalytic site [active] 661367003858 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367003859 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 661367003860 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 661367003861 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 661367003862 Ligand Binding Site [chemical binding]; other site 661367003863 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 661367003864 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 661367003865 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 661367003866 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 661367003867 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367003868 dimer interface [polypeptide binding]; other site 661367003869 active site 661367003870 CoA binding pocket [chemical binding]; other site 661367003871 Acyl transferase domain; Region: Acyl_transf_1; cl08282 661367003872 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367003873 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 661367003874 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 661367003875 NAD(P) binding site [chemical binding]; other site 661367003876 homotetramer interface [polypeptide binding]; other site 661367003877 homodimer interface [polypeptide binding]; other site 661367003878 active site 661367003879 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367003880 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367003881 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367003882 dimer interface [polypeptide binding]; other site 661367003883 active site 661367003884 YceG-like family; Region: YceG; pfam02618 661367003885 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 661367003886 dimerization interface [polypeptide binding]; other site 661367003887 thymidylate kinase; Validated; Region: tmk; PRK00698 661367003888 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 661367003889 TMP-binding site; other site 661367003890 ATP-binding site [chemical binding]; other site 661367003891 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 661367003892 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367003893 PilZ domain; Region: PilZ; cl01260 661367003894 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 661367003895 active site 661367003896 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 661367003897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367003898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003899 putative substrate translocation pore; other site 661367003900 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 661367003901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367003902 putative substrate translocation pore; other site 661367003903 F-box domain; Region: F-box; cl02535 661367003904 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 661367003905 Phosphotransferase enzyme family; Region: APH; pfam01636 661367003906 active site 661367003907 ATP binding site [chemical binding]; other site 661367003908 substrate binding site [chemical binding]; other site 661367003909 dimer interface [polypeptide binding]; other site 661367003910 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 661367003911 active site 661367003912 catalytic site [active] 661367003913 substrate binding site [chemical binding]; other site 661367003914 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 661367003915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 661367003916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 661367003917 catalytic residue [active] 661367003918 adenylate kinase; Reviewed; Region: adk; PRK00279 661367003919 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 661367003920 AMP-binding site [chemical binding]; other site 661367003921 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 661367003922 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 661367003923 catalytic residues [active] 661367003924 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 661367003925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367003926 glycerol kinase; Provisional; Region: glpK; PRK00047 661367003927 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 661367003928 N- and C-terminal domain interface [polypeptide binding]; other site 661367003929 active site 661367003930 MgATP binding site [chemical binding]; other site 661367003931 catalytic site [active] 661367003932 metal binding site [ion binding]; metal-binding site 661367003933 glycerol binding site [chemical binding]; other site 661367003934 homotetramer interface [polypeptide binding]; other site 661367003935 homodimer interface [polypeptide binding]; other site 661367003936 FBP binding site [chemical binding]; other site 661367003937 protein IIAGlc interface [polypeptide binding]; other site 661367003938 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 661367003939 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 661367003940 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 661367003941 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 661367003942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367003943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367003944 DNA binding residues [nucleotide binding] 661367003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367003946 S-adenosylmethionine binding site [chemical binding]; other site 661367003947 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367003948 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 661367003949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367003950 Walker A motif; other site 661367003951 ATP binding site [chemical binding]; other site 661367003952 Walker B motif; other site 661367003953 arginine finger; other site 661367003954 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 661367003955 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 661367003956 active site 661367003957 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 661367003958 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 661367003959 TolA protein; Region: tolA_full; TIGR02794 661367003960 Gram-negative bacterial tonB protein; Region: TonB; cl10048 661367003961 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 661367003962 TolB amino-terminal domain; Region: TolB_N; cl00639 661367003963 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367003964 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367003965 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367003966 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 661367003967 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 661367003968 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367003969 E3 interaction surface; other site 661367003970 lipoyl attachment site [posttranslational modification]; other site 661367003971 e3 binding domain; Region: E3_binding; pfam02817 661367003972 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 661367003973 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 661367003974 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 661367003975 alpha subunit interface [polypeptide binding]; other site 661367003976 TPP binding site [chemical binding]; other site 661367003977 heterodimer interface [polypeptide binding]; other site 661367003978 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367003979 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 661367003980 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 661367003981 TPP-binding site [chemical binding]; other site 661367003982 tetramer interface [polypeptide binding]; other site 661367003983 heterodimer interface [polypeptide binding]; other site 661367003984 phosphorylation loop region [posttranslational modification] 661367003985 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 661367003986 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 661367003987 chorismate binding enzyme; Region: Chorismate_bind; cl10555 661367003988 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 661367003989 putative active site [active] 661367003990 putative CoA binding site [chemical binding]; other site 661367003991 nudix motif; other site 661367003992 metal binding site [ion binding]; metal-binding site 661367003993 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 661367003994 AMP-binding enzyme; Region: AMP-binding; cl15778 661367003995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367003996 septum formation inhibitor; Reviewed; Region: minC; PRK04804 661367003997 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 661367003998 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 661367003999 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 661367004000 putative active site [active] 661367004001 putative metal binding site [ion binding]; other site 661367004002 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 661367004003 active site 661367004004 dinuclear metal binding site [ion binding]; other site 661367004005 dimerization interface [polypeptide binding]; other site 661367004006 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 661367004007 active site 661367004008 multimer interface [polypeptide binding]; other site 661367004009 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 661367004010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367004011 FeS/SAM binding site; other site 661367004012 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 661367004013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367004014 binding surface 661367004015 TPR motif; other site 661367004016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367004017 binding surface 661367004018 TPR motif; other site 661367004019 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 661367004020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367004021 histidyl-tRNA synthetase; Region: hisS; TIGR00442 661367004022 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 661367004023 dimer interface [polypeptide binding]; other site 661367004024 motif 1; other site 661367004025 active site 661367004026 motif 2; other site 661367004027 motif 3; other site 661367004028 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 661367004029 anticodon binding site; other site 661367004030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 661367004031 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 661367004032 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 661367004033 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 661367004034 Trp docking motif [polypeptide binding]; other site 661367004035 active site 661367004036 GTP-binding protein Der; Reviewed; Region: PRK00093 661367004037 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 661367004038 G1 box; other site 661367004039 GTP/Mg2+ binding site [chemical binding]; other site 661367004040 Switch I region; other site 661367004041 G2 box; other site 661367004042 Switch II region; other site 661367004043 G3 box; other site 661367004044 G4 box; other site 661367004045 G5 box; other site 661367004046 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 661367004047 G1 box; other site 661367004048 GTP/Mg2+ binding site [chemical binding]; other site 661367004049 Switch I region; other site 661367004050 G2 box; other site 661367004051 G3 box; other site 661367004052 Switch II region; other site 661367004053 G4 box; other site 661367004054 G5 box; other site 661367004055 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367004056 ligand binding site [chemical binding]; other site 661367004057 flexible hinge region; other site 661367004058 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 661367004059 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367004060 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367004061 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 661367004062 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 661367004063 putative active site [active] 661367004064 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367004065 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 661367004066 Walker A/P-loop; other site 661367004067 ATP binding site [chemical binding]; other site 661367004068 Q-loop/lid; other site 661367004069 ABC transporter signature motif; other site 661367004070 Walker B; other site 661367004071 D-loop; other site 661367004072 H-loop/switch region; other site 661367004073 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 661367004074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004075 Walker A/P-loop; other site 661367004076 ATP binding site [chemical binding]; other site 661367004077 Q-loop/lid; other site 661367004078 ABC transporter signature motif; other site 661367004079 Walker B; other site 661367004080 D-loop; other site 661367004081 H-loop/switch region; other site 661367004082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367004083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367004084 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 661367004085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367004086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367004087 Ligand Binding Site [chemical binding]; other site 661367004088 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 661367004089 catalytic center binding site [active] 661367004090 ATP binding site [chemical binding]; other site 661367004091 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 661367004092 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367004093 active site 661367004094 NTP binding site [chemical binding]; other site 661367004095 metal binding triad [ion binding]; metal-binding site 661367004096 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367004097 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 661367004098 Integral membrane protein TerC family; Region: TerC; cl10468 661367004099 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 661367004100 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 661367004101 Rubredoxin; Region: Rubredoxin; pfam00301 661367004102 iron binding site [ion binding]; other site 661367004103 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 661367004104 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367004105 inhibitor-cofactor binding pocket; inhibition site 661367004106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004107 catalytic residue [active] 661367004108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367004109 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 661367004110 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 661367004111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367004112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004113 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 661367004114 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 661367004115 tetramer interface [polypeptide binding]; other site 661367004116 active site 661367004117 Mg2+/Mn2+ binding site [ion binding]; other site 661367004118 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 661367004119 dimer interface [polypeptide binding]; other site 661367004120 Citrate synthase; Region: Citrate_synt; pfam00285 661367004121 active site 661367004122 citrylCoA binding site [chemical binding]; other site 661367004123 oxalacetate/citrate binding site [chemical binding]; other site 661367004124 coenzyme A binding site [chemical binding]; other site 661367004125 catalytic triad [active] 661367004126 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 661367004127 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 661367004128 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 661367004129 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 661367004130 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 661367004131 Spore germination protein; Region: Spore_permease; cl15802 661367004132 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 661367004133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367004134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004135 putative substrate translocation pore; other site 661367004136 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 661367004137 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 661367004138 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 661367004139 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 661367004140 putative NAD(P) binding site [chemical binding]; other site 661367004141 putative substrate binding site [chemical binding]; other site 661367004142 catalytic Zn binding site [ion binding]; other site 661367004143 structural Zn binding site [ion binding]; other site 661367004144 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367004145 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367004146 putative dimer interface [polypeptide binding]; other site 661367004147 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367004148 active site residue [active] 661367004149 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 661367004150 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367004151 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367004152 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 661367004153 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 661367004154 FAD binding domain; Region: FAD_binding_3; pfam01494 661367004155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 661367004156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 661367004157 active site 661367004158 catalytic tetrad [active] 661367004159 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367004160 classical (c) SDRs; Region: SDR_c; cd05233 661367004161 NAD(P) binding site [chemical binding]; other site 661367004162 active site 661367004163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367004164 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 661367004165 30S subunit binding site; other site 661367004166 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367004167 DNA-binding site [nucleotide binding]; DNA binding site 661367004168 RNA-binding motif; other site 661367004169 FOG: CBS domain [General function prediction only]; Region: COG0517 661367004170 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 661367004171 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 661367004172 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 661367004173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367004174 motif II; other site 661367004175 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 661367004176 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 661367004177 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 661367004178 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 661367004179 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 661367004180 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 661367004181 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 661367004182 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 661367004183 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 661367004184 Walker A motif; other site 661367004185 ATP binding site [chemical binding]; other site 661367004186 Walker B motif; other site 661367004187 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 661367004188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 661367004189 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 661367004190 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367004191 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 661367004192 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367004193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367004194 ligand binding site [chemical binding]; other site 661367004195 flexible hinge region; other site 661367004196 aminopeptidase N; Provisional; Region: pepN; PRK14015 661367004197 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 661367004198 Zn binding site [ion binding]; other site 661367004199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367004200 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 661367004201 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 661367004202 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 661367004203 GIY-YIG motif/motif A; other site 661367004204 putative active site [active] 661367004205 Preprotein translocase subunit SecA (ATPase, RNA helicase) [Intracellular trafficking and secretion]; Region: SecA; COG0653 661367004206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367004207 nucleotide binding region [chemical binding]; other site 661367004208 ATP-binding site [chemical binding]; other site 661367004209 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 661367004210 MG2 domain; Region: A2M_N; pfam01835 661367004211 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 661367004212 Alpha-2-macroglobulin family; Region: A2M; pfam00207 661367004213 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 661367004214 surface patch; other site 661367004215 thioester region; other site 661367004216 specificity defining residues; other site 661367004217 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 661367004218 Transglycosylase; Region: Transgly; cl07896 661367004219 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367004220 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 661367004221 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 661367004222 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 661367004223 malonyl-CoA binding site [chemical binding]; other site 661367004224 dimer interface [polypeptide binding]; other site 661367004225 active site 661367004226 product binding site; other site 661367004227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 661367004228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004229 S-adenosylmethionine binding site [chemical binding]; other site 661367004230 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 661367004231 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 661367004232 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367004233 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 661367004234 LysE type translocator; Region: LysE; cl00565 661367004235 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 661367004236 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367004237 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004238 catalytic residue [active] 661367004239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367004240 Helix-turn-helix domains; Region: HTH; cl00088 661367004241 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367004242 putative effector binding pocket; other site 661367004243 dimerization interface [polypeptide binding]; other site 661367004244 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 661367004245 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 661367004246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004247 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004248 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 661367004249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004250 DNA binding residues [nucleotide binding] 661367004251 dimerization interface [polypeptide binding]; other site 661367004252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004253 non-specific DNA binding site [nucleotide binding]; other site 661367004254 salt bridge; other site 661367004255 sequence-specific DNA binding site [nucleotide binding]; other site 661367004256 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 661367004257 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 661367004258 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 661367004259 catalytic residues [active] 661367004260 catalytic nucleophile [active] 661367004261 Presynaptic Site I dimer interface [polypeptide binding]; other site 661367004262 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 661367004263 Synaptic Flat tetramer interface [polypeptide binding]; other site 661367004264 Synaptic Site I dimer interface [polypeptide binding]; other site 661367004265 DNA binding site [nucleotide binding] 661367004266 Helix-turn-helix domains; Region: HTH; cl00088 661367004267 Restriction endonuclease; Region: Mrr_cat; cl00516 661367004268 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 661367004269 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367004270 Transposase domain (DUF772); Region: DUF772; cl15789 661367004271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367004272 Transposase domain (DUF772); Region: DUF772; cl15789 661367004273 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 661367004274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004275 non-specific DNA binding site [nucleotide binding]; other site 661367004276 salt bridge; other site 661367004277 sequence-specific DNA binding site [nucleotide binding]; other site 661367004278 shikimate kinase; Reviewed; Region: aroK; PRK00131 661367004279 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 661367004280 ADP binding site [chemical binding]; other site 661367004281 magnesium binding site [ion binding]; other site 661367004282 putative shikimate binding site; other site 661367004283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004284 DNA binding residues [nucleotide binding] 661367004285 dimerization interface [polypeptide binding]; other site 661367004286 Cupin domain; Region: Cupin_2; cl09118 661367004287 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367004288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004289 S-adenosylmethionine binding site [chemical binding]; other site 661367004290 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367004291 Substrate binding site [chemical binding]; other site 661367004292 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 661367004293 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004294 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367004295 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004300 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367004301 Protein required for attachment to host cells; Region: Host_attach; cl02398 661367004302 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 661367004303 Domain of unknown function DUF21; Region: DUF21; pfam01595 661367004304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367004305 Transporter associated domain; Region: CorC_HlyC; cl08393 661367004306 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 661367004307 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 661367004308 classical (c) SDRs; Region: SDR_c; cd05233 661367004309 NAD(P) binding site [chemical binding]; other site 661367004310 active site 661367004311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367004312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367004313 substrate binding pocket [chemical binding]; other site 661367004314 membrane-bound complex binding site; other site 661367004315 hinge residues; other site 661367004316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004317 Zeta toxin; Region: Zeta_toxin; pfam06414 661367004318 OpgC protein; Region: OpgC_C; cl00792 661367004319 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367004320 Uncharacterized conserved protein [Function unknown]; Region: COG1912 661367004321 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 661367004322 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 661367004323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 661367004324 active site 661367004325 catalytic tetrad [active] 661367004326 OpgC protein; Region: OpgC_C; cl00792 661367004327 Acyltransferase family; Region: Acyl_transf_3; pfam01757 661367004328 amidase; Provisional; Region: PRK08137 661367004329 Amidase; Region: Amidase; cl11426 661367004330 formate dehydrogenase; Provisional; Region: PRK07574 661367004331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004332 Cache domain; Region: Cache_1; pfam02743 661367004333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367004334 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367004335 cyclase homology domain; Region: CHD; cd07302 661367004336 nucleotidyl binding site; other site 661367004337 metal binding site [ion binding]; metal-binding site 661367004338 dimer interface [polypeptide binding]; other site 661367004339 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 661367004340 dimer interface [polypeptide binding]; other site 661367004341 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 661367004342 Amidase; Region: Amidase; cl11426 661367004343 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 661367004344 classical (c) SDRs; Region: SDR_c; cd05233 661367004345 NAD(P) binding site [chemical binding]; other site 661367004346 active site 661367004347 Helix-turn-helix domains; Region: HTH; cl00088 661367004348 DDE domain; Region: DDE_Tnp_IS240; pfam13610 661367004349 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 661367004350 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367004351 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367004352 active site 661367004353 ATP binding site [chemical binding]; other site 661367004354 substrate binding site [chemical binding]; other site 661367004355 activation loop (A-loop); other site 661367004356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367004357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367004358 active site 661367004359 ATP binding site [chemical binding]; other site 661367004360 substrate binding site [chemical binding]; other site 661367004361 activation loop (A-loop); other site 661367004362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004363 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367004364 putative substrate translocation pore; other site 661367004365 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 661367004366 putative DNA-binding cleft [nucleotide binding]; other site 661367004367 putative DNA clevage site; other site 661367004368 molecular lever; other site 661367004369 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 661367004370 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367004371 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367004372 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 661367004373 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 661367004374 dimer interface [polypeptide binding]; other site 661367004375 anticodon binding site; other site 661367004376 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 661367004377 homodimer interface [polypeptide binding]; other site 661367004378 motif 1; other site 661367004379 active site 661367004380 motif 2; other site 661367004381 GAD domain; Region: GAD; pfam02938 661367004382 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 661367004383 motif 3; other site 661367004384 Protein of unknown function (DUF502); Region: DUF502; cl01107 661367004385 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 661367004386 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 661367004387 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 661367004388 PAS domain; Region: PAS_9; pfam13426 661367004389 Response regulator receiver domain; Region: Response_reg; pfam00072 661367004390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367004391 active site 661367004392 phosphorylation site [posttranslational modification] 661367004393 intermolecular recognition site; other site 661367004394 dimerization interface [polypeptide binding]; other site 661367004395 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 661367004396 short chain dehydrogenase; Validated; Region: PRK06182 661367004397 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 661367004398 NADP binding site [chemical binding]; other site 661367004399 active site 661367004400 steroid binding site; other site 661367004401 aconitate hydratase; Validated; Region: PRK09277 661367004402 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367004403 substrate binding site [chemical binding]; other site 661367004404 ligand binding site [chemical binding]; other site 661367004405 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367004406 substrate binding site [chemical binding]; other site 661367004407 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367004408 Spore germination protein; Region: Spore_permease; cl15802 661367004409 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 661367004410 Proline dehydrogenase; Region: Pro_dh; cl03282 661367004411 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 661367004412 Glutamate binding site [chemical binding]; other site 661367004413 NAD binding site [chemical binding]; other site 661367004414 catalytic residues [active] 661367004415 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367004416 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 661367004417 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 661367004418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004419 S-adenosylmethionine binding site [chemical binding]; other site 661367004420 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 661367004421 ligand binding site [chemical binding]; other site 661367004422 active site 661367004423 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 661367004424 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 661367004425 metal binding site [ion binding]; metal-binding site 661367004426 dimer interface [polypeptide binding]; other site 661367004427 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 661367004428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367004429 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 661367004430 NAD(P) binding site [chemical binding]; other site 661367004431 catalytic residues [active] 661367004432 Succinylarginine dihydrolase; Region: AstB; cl01511 661367004433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367004434 Omptin family; Region: Omptin; cl01886 661367004435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004436 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367004437 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 661367004438 Rab subfamily motif 1 (RabSF1); other site 661367004439 G1 box; other site 661367004440 GTP/Mg2+ binding site [chemical binding]; other site 661367004441 Rab subfamily motif 2 (RabSF2); other site 661367004442 Switch I region; other site 661367004443 G2 box; other site 661367004444 effector interaction site; other site 661367004445 GDI interaction site; other site 661367004446 Rab family motif 1 (RabF1); other site 661367004447 GEF interaction site [polypeptide binding]; other site 661367004448 Rab family motif 2 (RabF2); other site 661367004449 G3 box; other site 661367004450 Switch II region; other site 661367004451 Rab family motif 3 (RabF3); other site 661367004452 Rab family motif 4 (RabF4); other site 661367004453 Rab family motif 5 (RabF5); other site 661367004454 Rab subfamily motif 3 (RabSF3); other site 661367004455 G4 box; other site 661367004456 G5 box; other site 661367004457 Rab subfamily motif 4 (RabSF4); other site 661367004458 ribosome recycling factor; Reviewed; Region: frr; PRK00083 661367004459 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 661367004460 hinge region; other site 661367004461 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 661367004462 putative nucleotide binding site [chemical binding]; other site 661367004463 uridine monophosphate binding site [chemical binding]; other site 661367004464 homohexameric interface [polypeptide binding]; other site 661367004465 elongation factor Ts; Provisional; Region: tsf; PRK09377 661367004466 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 661367004467 Elongation factor TS; Region: EF_TS; pfam00889 661367004468 Elongation factor TS; Region: EF_TS; pfam00889 661367004469 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 661367004470 rRNA interaction site [nucleotide binding]; other site 661367004471 S8 interaction site; other site 661367004472 putative laminin-1 binding site; other site 661367004473 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 661367004474 dimer interface [polypeptide binding]; other site 661367004475 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 661367004476 YceI-like domain; Region: YceI; cl01001 661367004477 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 661367004478 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 661367004479 AAA domain; Region: AAA_26; pfam13500 661367004480 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004481 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 661367004482 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367004483 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 661367004484 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367004485 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004486 catalytic residue [active] 661367004487 biotin synthase; Region: bioB; TIGR00433 661367004488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367004489 FeS/SAM binding site; other site 661367004490 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 661367004491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367004492 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 661367004493 inhibitor-cofactor binding pocket; inhibition site 661367004494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004495 catalytic residue [active] 661367004496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367004497 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 661367004498 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 661367004499 CoA-binding site [chemical binding]; other site 661367004500 ATP-binding [chemical binding]; other site 661367004501 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 661367004502 active site 661367004503 8-oxo-dGMP binding site [chemical binding]; other site 661367004504 nudix motif; other site 661367004505 metal binding site [ion binding]; metal-binding site 661367004506 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 661367004507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004508 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 661367004509 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004510 nucleotide binding region [chemical binding]; other site 661367004511 SEC-C motif; Region: SEC-C; pfam02810 661367004512 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 661367004513 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 661367004514 FMN binding site [chemical binding]; other site 661367004515 active site 661367004516 catalytic residues [active] 661367004517 substrate binding site [chemical binding]; other site 661367004518 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004519 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367004520 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004521 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004522 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004523 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 661367004524 DHH family; Region: DHH; pfam01368 661367004525 DHHA1 domain; Region: DHHA1; pfam02272 661367004526 Sulfatase; Region: Sulfatase; cl10460 661367004527 aminotransferase; Validated; Region: PRK08175 661367004528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367004529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004530 homodimer interface [polypeptide binding]; other site 661367004531 catalytic residue [active] 661367004532 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 661367004533 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 661367004534 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367004535 active site 661367004536 nucleophile elbow; other site 661367004537 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 661367004538 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 661367004539 cyclase homology domain; Region: CHD; cd07302 661367004540 nucleotidyl binding site; other site 661367004541 metal binding site [ion binding]; metal-binding site 661367004542 dimer interface [polypeptide binding]; other site 661367004543 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 661367004544 active site 661367004545 GIY-YIG motif/motif A; other site 661367004546 catalytic site [active] 661367004547 metal binding site [ion binding]; metal-binding site 661367004548 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 661367004549 Protein of unknown function (DUF692); Region: DUF692; cl01263 661367004550 YceI-like domain; Region: YceI; cl01001 661367004551 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 661367004552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 661367004553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 661367004554 synthetase active site [active] 661367004555 NTP binding site [chemical binding]; other site 661367004556 metal binding site [ion binding]; metal-binding site 661367004557 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 661367004558 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 661367004559 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 661367004560 TRAM domain; Region: TRAM; cl01282 661367004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004562 S-adenosylmethionine binding site [chemical binding]; other site 661367004563 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 661367004564 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367004565 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 661367004566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367004568 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367004569 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 661367004570 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367004571 E3 interaction surface; other site 661367004572 lipoyl attachment site [posttranslational modification]; other site 661367004573 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367004574 E3 interaction surface; other site 661367004575 lipoyl attachment site [posttranslational modification]; other site 661367004576 e3 binding domain; Region: E3_binding; pfam02817 661367004577 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 661367004578 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 661367004579 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 661367004580 dimer interface [polypeptide binding]; other site 661367004581 TPP-binding site [chemical binding]; other site 661367004582 CobD/Cbib protein; Region: CobD_Cbib; cl00561 661367004583 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367004584 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367004585 rare lipoprotein A; Provisional; Region: PRK10672 661367004586 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 661367004587 Sporulation related domain; Region: SPOR; cl10051 661367004588 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 661367004589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367004590 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 661367004591 Protein of unknown function (DUF493); Region: DUF493; cl01102 661367004592 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 661367004593 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 661367004594 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 661367004595 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 661367004596 active site 661367004597 LssY C-terminus; Region: LssY_C; pfam14067 661367004598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 661367004599 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 661367004600 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367004601 RNA binding surface [nucleotide binding]; other site 661367004602 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 661367004603 probable active site [active] 661367004604 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 661367004605 ScpA/B protein; Region: ScpA_ScpB; cl00598 661367004606 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 661367004607 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 661367004608 active site 661367004609 HIGH motif; other site 661367004610 dimer interface [polypeptide binding]; other site 661367004611 KMSKS motif; other site 661367004612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367004613 active site 661367004614 KMSKS motif; other site 661367004615 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 661367004616 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 661367004617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004618 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 661367004619 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 661367004620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 661367004621 Transporter associated domain; Region: CorC_HlyC; cl08393 661367004622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367004624 active site 661367004625 phosphorylation site [posttranslational modification] 661367004626 intermolecular recognition site; other site 661367004627 dimerization interface [polypeptide binding]; other site 661367004628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367004629 DNA binding site [nucleotide binding] 661367004630 two-component sensor protein; Provisional; Region: cpxA; PRK09470 661367004631 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 661367004632 dimerization interface [polypeptide binding]; other site 661367004633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367004634 dimer interface [polypeptide binding]; other site 661367004635 phosphorylation site [posttranslational modification] 661367004636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367004637 ATP binding site [chemical binding]; other site 661367004638 Mg2+ binding site [ion binding]; other site 661367004639 G-X-G motif; other site 661367004640 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 661367004641 active site 661367004642 catalytic motif [active] 661367004643 Zn binding site [ion binding]; other site 661367004644 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 661367004645 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 661367004646 catalytic residue [active] 661367004647 UbiA prenyltransferase family; Region: UbiA; cl00337 661367004648 UTRA domain; Region: UTRA; cl01230 661367004649 Type II transport protein GspH; Region: GspH; pfam12019 661367004650 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 661367004651 active site 661367004652 nucleophile elbow; other site 661367004653 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 661367004654 active site 661367004655 dimer interface [polypeptide binding]; other site 661367004656 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 661367004657 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 661367004658 inhibitor-cofactor binding pocket; inhibition site 661367004659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367004660 catalytic residue [active] 661367004661 tetratricopeptide repeat protein; Provisional; Region: PRK11788 661367004662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367004663 TPR motif; other site 661367004664 binding surface 661367004665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367004666 binding surface 661367004667 TPR motif; other site 661367004668 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 661367004669 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 661367004670 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 661367004671 RNA binding site [nucleotide binding]; other site 661367004672 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 661367004673 RNA binding site [nucleotide binding]; other site 661367004674 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 661367004675 RNA binding site [nucleotide binding]; other site 661367004676 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 661367004677 RNA binding site [nucleotide binding]; other site 661367004678 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367004679 RNA binding site [nucleotide binding]; other site 661367004680 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 661367004681 RNA binding site [nucleotide binding]; other site 661367004682 cytidylate kinase; Provisional; Region: cmk; PRK00023 661367004683 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 661367004684 CMP-binding site; other site 661367004685 The sites determining sugar specificity; other site 661367004686 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 661367004687 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 661367004688 hinge; other site 661367004689 active site 661367004690 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367004691 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367004692 catalytic residue [active] 661367004693 DNA gyrase subunit A; Validated; Region: PRK05560 661367004694 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 661367004695 CAP-like domain; other site 661367004696 active site 661367004697 primary dimer interface [polypeptide binding]; other site 661367004698 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004699 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004700 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004701 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004702 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 661367004703 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 661367004704 dimer interface [polypeptide binding]; other site 661367004705 Citrate synthase; Region: Citrate_synt; pfam00285 661367004706 active site 661367004707 citrylCoA binding site [chemical binding]; other site 661367004708 NADH binding [chemical binding]; other site 661367004709 cationic pore residues; other site 661367004710 oxalacetate/citrate binding site [chemical binding]; other site 661367004711 coenzyme A binding site [chemical binding]; other site 661367004712 catalytic triad [active] 661367004713 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 661367004714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004715 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367004716 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 661367004717 NAD(P) binding site [chemical binding]; other site 661367004718 catalytic residues [active] 661367004719 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367004720 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 661367004721 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 661367004722 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 661367004723 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 661367004724 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 661367004725 Global regulator protein family; Region: CsrA; cl00670 661367004726 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 661367004727 active site 661367004728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 661367004729 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367004730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367004731 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 661367004732 substrate binding site [chemical binding]; other site 661367004733 oxyanion hole (OAH) forming residues; other site 661367004734 trimer interface [polypeptide binding]; other site 661367004735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004736 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 661367004737 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 661367004738 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367004739 dimer interface [polypeptide binding]; other site 661367004740 active site 661367004741 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 661367004742 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 661367004743 Int/Topo IB signature motif; other site 661367004744 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 661367004745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367004746 DNA binding residues [nucleotide binding] 661367004747 dimerization interface [polypeptide binding]; other site 661367004748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004749 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367004750 putative substrate translocation pore; other site 661367004751 Methyltransferase domain; Region: Methyltransf_31; pfam13847 661367004752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367004753 S-adenosylmethionine binding site [chemical binding]; other site 661367004754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367004755 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 661367004756 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 661367004757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004758 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 661367004759 F sex factor protein N terminal; Region: TraD_N; pfam12615 661367004760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004761 Walker A motif; other site 661367004762 ATP binding site [chemical binding]; other site 661367004763 Walker B motif; other site 661367004764 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 661367004765 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 661367004766 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367004767 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367004768 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 661367004769 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 661367004770 TraU protein; Region: TraU; cl06067 661367004771 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 661367004772 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515 661367004773 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 661367004774 Domain of unknown function DUF87; Region: DUF87; pfam01935 661367004775 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 661367004776 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 661367004777 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 661367004778 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 661367004779 TraE protein; Region: TraE; cl05060 661367004780 TraL protein; Region: TraL; cl06278 661367004781 Global regulator protein family; Region: CsrA; cl00670 661367004782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367004783 non-specific DNA binding site [nucleotide binding]; other site 661367004784 salt bridge; other site 661367004785 sequence-specific DNA binding site [nucleotide binding]; other site 661367004786 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367004787 Catalytic site [active] 661367004788 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367004789 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367004790 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367004791 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 661367004792 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 661367004793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004794 DEAD_2; Region: DEAD_2; pfam06733 661367004795 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367004796 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 661367004797 active site 661367004798 catalytic site [active] 661367004799 substrate binding site [chemical binding]; other site 661367004800 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 661367004801 GIY-YIG motif/motif A; other site 661367004802 active site 661367004803 catalytic site [active] 661367004804 putative DNA binding site [nucleotide binding]; other site 661367004805 metal binding site [ion binding]; metal-binding site 661367004806 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367004807 active site 661367004808 DNA polymerase IV; Validated; Region: PRK02406 661367004809 DNA binding site [nucleotide binding] 661367004810 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367004811 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367004812 active site 661367004813 DNA binding site [nucleotide binding] 661367004814 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367004815 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367004816 Catalytic site [active] 661367004817 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 661367004818 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367004819 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 661367004820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367004821 Ligand Binding Site [chemical binding]; other site 661367004822 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367004823 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367004824 putative active site [active] 661367004825 putative NTP binding site [chemical binding]; other site 661367004826 putative nucleic acid binding site [nucleotide binding]; other site 661367004827 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 661367004828 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367004829 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367004830 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367004831 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367004832 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367004833 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 661367004834 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 661367004835 active site 661367004836 dimer interface [polypeptide binding]; other site 661367004837 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 661367004838 Ligand Binding Site [chemical binding]; other site 661367004839 Molecular Tunnel; other site 661367004840 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 661367004841 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 661367004842 putative active site [active] 661367004843 Zn binding site [ion binding]; other site 661367004844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367004845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367004846 putative substrate translocation pore; other site 661367004847 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367004848 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 661367004849 putative active site [active] 661367004850 putative NTP binding site [chemical binding]; other site 661367004851 putative nucleic acid binding site [nucleotide binding]; other site 661367004852 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367004853 Transposase domain (DUF772); Region: DUF772; cl15789 661367004854 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 661367004855 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367004856 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 661367004857 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 661367004858 Cl- selectivity filter; other site 661367004859 Cl- binding residues [ion binding]; other site 661367004860 pore gating glutamate residue; other site 661367004861 dimer interface [polypeptide binding]; other site 661367004862 H+/Cl- coupling transport residue; other site 661367004863 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 661367004864 Immunoglobulin I-set domain; Region: I-set; pfam07679 661367004865 Immunoglobulin domain; Region: Ig; cl11960 661367004866 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 661367004867 Immunoglobulin I-set domain; Region: I-set; pfam07679 661367004868 Immunoglobulin domain; Region: Ig; cl11960 661367004869 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 661367004870 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 661367004871 Asp-box motif; other site 661367004872 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 661367004873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367004874 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004875 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004876 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004877 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367004878 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367004879 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367004880 ligand binding site [chemical binding]; other site 661367004881 CAAX protease self-immunity; Region: Abi; cl00558 661367004882 Zeta toxin; Region: Zeta_toxin; pfam06414 661367004883 TROVE domain; Region: TROVE; pfam05731 661367004884 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 661367004885 Cupin domain; Region: Cupin_2; cl09118 661367004886 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367004887 MepB protein; Region: MepB; cl01985 661367004888 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367004889 Integrase core domain; Region: rve; cl01316 661367004890 elongation factor G; Reviewed; Region: PRK00007 661367004891 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 661367004892 G1 box; other site 661367004893 putative GEF interaction site [polypeptide binding]; other site 661367004894 GTP/Mg2+ binding site [chemical binding]; other site 661367004895 Switch I region; other site 661367004896 G2 box; other site 661367004897 G3 box; other site 661367004898 Switch II region; other site 661367004899 G4 box; other site 661367004900 G5 box; other site 661367004901 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 661367004902 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 661367004903 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 661367004904 RES domain; Region: RES; cl02411 661367004905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367004906 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 661367004907 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 661367004908 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367004909 YCII-related domain; Region: YCII; cl00999 661367004910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367004911 dimer interface [polypeptide binding]; other site 661367004912 conserved gate region; other site 661367004913 putative PBP binding loops; other site 661367004914 ABC-ATPase subunit interface; other site 661367004915 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 661367004916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367004917 dimer interface [polypeptide binding]; other site 661367004918 putative PBP binding loops; other site 661367004919 ABC-ATPase subunit interface; other site 661367004920 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 661367004921 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 661367004922 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 661367004923 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 661367004924 nucleotide binding pocket [chemical binding]; other site 661367004925 K-X-D-G motif; other site 661367004926 catalytic site [active] 661367004927 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 661367004928 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 661367004929 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 661367004930 Dimer interface [polypeptide binding]; other site 661367004931 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 661367004932 RmuC family; Region: RmuC; pfam02646 661367004933 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 661367004934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 661367004935 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 661367004936 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 661367004937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367004938 ATP binding site [chemical binding]; other site 661367004939 putative Mg++ binding site [ion binding]; other site 661367004940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367004941 nucleotide binding region [chemical binding]; other site 661367004942 ATP-binding site [chemical binding]; other site 661367004943 TRCF domain; Region: TRCF; cl04088 661367004944 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 661367004945 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 661367004946 Predicted amidohydrolase [General function prediction only]; Region: COG0388 661367004947 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 661367004948 putative active site [active] 661367004949 catalytic triad [active] 661367004950 dimer interface [polypeptide binding]; other site 661367004951 YccA-like proteins; Region: YccA_like; cd10433 661367004952 PAS fold; Region: PAS; pfam00989 661367004953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 661367004954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367004955 metal binding site [ion binding]; metal-binding site 661367004956 active site 661367004957 I-site; other site 661367004958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367004959 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 661367004960 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 661367004961 TPP-binding site [chemical binding]; other site 661367004962 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 661367004963 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 661367004964 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 661367004965 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 661367004966 dimer interface [polypeptide binding]; other site 661367004967 PYR/PP interface [polypeptide binding]; other site 661367004968 TPP binding site [chemical binding]; other site 661367004969 substrate binding site [chemical binding]; other site 661367004970 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 661367004971 active site 661367004972 hydrophilic channel; other site 661367004973 dimerization interface [polypeptide binding]; other site 661367004974 catalytic residues [active] 661367004975 active site lid [active] 661367004976 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 661367004977 Recombination protein O N terminal; Region: RecO_N; cl15812 661367004978 Recombination protein O C terminal; Region: RecO_C; pfam02565 661367004979 GTPase Era; Reviewed; Region: era; PRK00089 661367004980 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 661367004981 G1 box; other site 661367004982 GTP/Mg2+ binding site [chemical binding]; other site 661367004983 Switch I region; other site 661367004984 G2 box; other site 661367004985 Switch II region; other site 661367004986 G3 box; other site 661367004987 G4 box; other site 661367004988 G5 box; other site 661367004989 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 661367004990 chromosome segregation protein; Provisional; Region: PRK03918 661367004991 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 661367004992 active site 661367004993 intersubunit interface [polypeptide binding]; other site 661367004994 catalytic residue [active] 661367004995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367004996 Helix-turn-helix domains; Region: HTH; cl00088 661367004997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367004998 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 661367004999 lipoprotein signal peptidase; Provisional; Region: PRK14787 661367005000 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 661367005001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367005002 active site 661367005003 HIGH motif; other site 661367005004 nucleotide binding site [chemical binding]; other site 661367005005 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367005006 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 661367005007 active site 661367005008 KMSKS motif; other site 661367005009 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 661367005010 tRNA binding surface [nucleotide binding]; other site 661367005011 anticodon binding site; other site 661367005012 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 661367005013 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 661367005014 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 661367005015 active site 661367005016 Riboflavin kinase; Region: Flavokinase; cl03312 661367005017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367005018 Ligand Binding Site [chemical binding]; other site 661367005019 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 661367005020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367005021 binding surface 661367005022 TPR motif; other site 661367005023 Cytochrome C biogenesis protein; Region: CcmH; cl01179 661367005024 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 661367005025 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 661367005026 catalytic residues [active] 661367005027 central insert; other site 661367005028 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 661367005029 CcmE; Region: CcmE; cl00994 661367005030 Heme exporter protein D (CcmD); Region: CcmD; cl11475 661367005031 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 661367005032 CcmB protein; Region: CcmB; cl01016 661367005033 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 661367005034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005035 Walker A/P-loop; other site 661367005036 ATP binding site [chemical binding]; other site 661367005037 Q-loop/lid; other site 661367005038 ABC transporter signature motif; other site 661367005039 Walker B; other site 661367005040 D-loop; other site 661367005041 H-loop/switch region; other site 661367005042 Helix-turn-helix domains; Region: HTH; cl00088 661367005043 putative transposase OrfB; Reviewed; Region: PHA02517 661367005044 HTH-like domain; Region: HTH_21; pfam13276 661367005045 Integrase core domain; Region: rve; cl01316 661367005046 Integrase core domain; Region: rve_3; cl15866 661367005047 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 661367005048 putative active site [active] 661367005049 metal binding site [ion binding]; metal-binding site 661367005050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005051 Helix-turn-helix domains; Region: HTH; cl00088 661367005052 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367005053 putative effector binding pocket; other site 661367005054 dimerization interface [polypeptide binding]; other site 661367005055 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 661367005056 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 661367005057 Zn binding site [ion binding]; other site 661367005058 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005059 active site 661367005060 ATP binding site [chemical binding]; other site 661367005061 substrate binding site [chemical binding]; other site 661367005062 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005063 substrate binding site [chemical binding]; other site 661367005064 activation loop (A-loop); other site 661367005065 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367005066 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367005067 active site 661367005068 DNA binding site [nucleotide binding] 661367005069 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367005070 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367005071 Catalytic site [active] 661367005072 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 661367005073 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 661367005074 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367005075 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 661367005076 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367005077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367005078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367005079 catalytic residue [active] 661367005080 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367005081 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 661367005082 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367005083 active site 661367005084 metal binding site [ion binding]; metal-binding site 661367005085 TspO/MBR family; Region: TspO_MBR; cl01379 661367005086 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 661367005087 putative NAD(P) binding site [chemical binding]; other site 661367005088 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367005089 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 661367005090 DNA photolyase; Region: DNA_photolyase; pfam00875 661367005091 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 661367005092 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 661367005093 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 661367005094 Sensors of blue-light using FAD; Region: BLUF; cl04855 661367005095 PAS domain S-box; Region: sensory_box; TIGR00229 661367005096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005097 putative active site [active] 661367005098 heme pocket [chemical binding]; other site 661367005099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005100 PAS domain; Region: PAS_9; pfam13426 661367005101 putative active site [active] 661367005102 heme pocket [chemical binding]; other site 661367005103 PAS domain S-box; Region: sensory_box; TIGR00229 661367005104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 661367005105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367005106 metal binding site [ion binding]; metal-binding site 661367005107 active site 661367005108 I-site; other site 661367005109 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 661367005110 putative inner membrane peptidase; Provisional; Region: PRK11778 661367005111 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 661367005112 tandem repeat interface [polypeptide binding]; other site 661367005113 oligomer interface [polypeptide binding]; other site 661367005114 active site residues [active] 661367005115 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367005116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 661367005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005118 Walker A motif; other site 661367005119 ATP binding site [chemical binding]; other site 661367005120 Walker B motif; other site 661367005121 arginine finger; other site 661367005122 Helix-turn-helix domains; Region: HTH; cl00088 661367005123 Uncharacterized conserved protein [Function unknown]; Region: COG0327 661367005124 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 661367005125 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 661367005126 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 661367005127 hinge; other site 661367005128 active site 661367005129 BolA-like protein; Region: BolA; cl00386 661367005130 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 661367005131 anti sigma factor interaction site; other site 661367005132 regulatory phosphorylation site [posttranslational modification]; other site 661367005133 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 661367005134 mce related protein; Region: MCE; pfam02470 661367005135 Permease; Region: Permease; cl00510 661367005136 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 661367005137 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 661367005138 Walker A/P-loop; other site 661367005139 ATP binding site [chemical binding]; other site 661367005140 Q-loop/lid; other site 661367005141 ABC transporter signature motif; other site 661367005142 Walker B; other site 661367005143 D-loop; other site 661367005144 H-loop/switch region; other site 661367005145 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 661367005146 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 661367005147 putative active site [active] 661367005148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 661367005149 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 661367005150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005151 active site 661367005152 motif I; other site 661367005153 motif II; other site 661367005154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 661367005155 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 661367005156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 661367005157 OstA-like protein; Region: OstA; cl00844 661367005158 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 661367005159 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 661367005160 Walker A/P-loop; other site 661367005161 ATP binding site [chemical binding]; other site 661367005162 Q-loop/lid; other site 661367005163 ABC transporter signature motif; other site 661367005164 Walker B; other site 661367005165 D-loop; other site 661367005166 H-loop/switch region; other site 661367005167 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 661367005168 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 661367005169 glutamine binding [chemical binding]; other site 661367005170 catalytic triad [active] 661367005171 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 661367005172 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 661367005173 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 661367005174 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 661367005175 active site 661367005176 ribulose/triose binding site [chemical binding]; other site 661367005177 phosphate binding site [ion binding]; other site 661367005178 substrate (anthranilate) binding pocket [chemical binding]; other site 661367005179 product (indole) binding pocket [chemical binding]; other site 661367005180 hypothetical protein; Provisional; Region: PRK06194 661367005181 classical (c) SDRs; Region: SDR_c; cd05233 661367005182 NAD(P) binding site [chemical binding]; other site 661367005183 active site 661367005184 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 661367005185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005186 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 661367005187 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 661367005188 generic binding surface II; other site 661367005189 generic binding surface I; other site 661367005190 Rhomboid family; Region: Rhomboid; cl11446 661367005191 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 661367005192 dimer interface [polypeptide binding]; other site 661367005193 substrate binding site [chemical binding]; other site 661367005194 ATP binding site [chemical binding]; other site 661367005195 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 661367005196 O-Antigen ligase; Region: Wzy_C; cl04850 661367005197 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 661367005198 putative metal binding site; other site 661367005199 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 661367005200 Clp amino terminal domain; Region: Clp_N; pfam02861 661367005201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005202 Walker A motif; other site 661367005203 ATP binding site [chemical binding]; other site 661367005204 Walker B motif; other site 661367005205 arginine finger; other site 661367005206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005207 Walker A motif; other site 661367005208 ATP binding site [chemical binding]; other site 661367005209 Walker B motif; other site 661367005210 arginine finger; other site 661367005211 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 661367005212 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 661367005213 isocitrate dehydrogenase; Validated; Region: PRK07362 661367005214 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 661367005215 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 661367005216 pseudouridine synthase; Region: TIGR00093 661367005217 active site 661367005218 rod shape-determining protein MreD; Region: MreD; cl01087 661367005219 rod shape-determining protein MreC; Provisional; Region: PRK13922 661367005220 rod shape-determining protein MreC; Region: MreC; pfam04085 661367005221 rod shape-determining protein MreB; Provisional; Region: PRK13927 661367005222 hypothetical protein; Provisional; Region: PRK10039 661367005223 Cell division protein FtsA; Region: FtsA; cl11496 661367005224 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 661367005225 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 661367005226 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 661367005227 metal binding site [ion binding]; metal-binding site 661367005228 putative dimer interface [polypeptide binding]; other site 661367005229 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 661367005230 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 661367005231 active site 661367005232 homodimer interface [polypeptide binding]; other site 661367005233 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 661367005234 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 661367005235 dimerization interface [polypeptide binding]; other site 661367005236 active site 661367005237 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367005238 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367005239 phosphoenolpyruvate synthase; Validated; Region: PRK06464 661367005240 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 661367005241 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 661367005242 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 661367005243 adenylosuccinate lyase; Provisional; Region: PRK09285 661367005244 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 661367005245 tetramer interface [polypeptide binding]; other site 661367005246 active site 661367005247 L-aspartate oxidase; Provisional; Region: PRK09077 661367005248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005249 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 661367005250 Quinolinate synthetase A protein; Region: NadA; cl00420 661367005251 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 661367005252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367005253 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367005254 muropeptide transporter; Validated; Region: ampG; PRK11010 661367005255 muropeptide transporter; Reviewed; Region: ampG; PRK11902 661367005256 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 661367005257 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 661367005258 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 661367005259 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 661367005260 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 661367005261 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 661367005262 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 661367005263 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 661367005264 Ligand Binding Site [chemical binding]; other site 661367005265 TilS substrate binding domain; Region: TilS; pfam09179 661367005266 B3/4 domain; Region: B3_4; cl11458 661367005267 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367005268 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 661367005269 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 661367005270 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 661367005271 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 661367005272 Helix-turn-helix domains; Region: HTH; cl00088 661367005273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 661367005274 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 661367005275 Global regulator protein family; Region: CsrA; cl00670 661367005276 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 661367005277 Mg++ binding site [ion binding]; other site 661367005278 putative catalytic motif [active] 661367005279 putative substrate binding site [chemical binding]; other site 661367005280 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367005281 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 661367005282 putative NAD(P) binding site [chemical binding]; other site 661367005283 active site 661367005284 putative substrate binding site [chemical binding]; other site 661367005285 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 661367005286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367005288 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 661367005289 lipoyl synthase; Provisional; Region: PRK05481 661367005290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367005291 FeS/SAM binding site; other site 661367005292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367005293 FOG: CBS domain [General function prediction only]; Region: COG0517 661367005294 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 661367005295 BON domain; Region: BON; cl02771 661367005296 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 661367005297 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367005298 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 661367005299 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367005300 HSP70 interaction site [polypeptide binding]; other site 661367005301 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 661367005302 substrate binding site [polypeptide binding]; other site 661367005303 dimer interface [polypeptide binding]; other site 661367005304 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 661367005305 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 661367005306 Septum formation initiator; Region: DivIC; cl11433 661367005307 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 661367005308 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 661367005309 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 661367005310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367005311 binding surface 661367005312 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 661367005313 TPR motif; other site 661367005314 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 661367005315 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367005316 ligand binding site [chemical binding]; other site 661367005317 Protein of unknown function (DUF330); Region: DUF330; cl01135 661367005318 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 661367005319 mce related protein; Region: MCE; pfam02470 661367005320 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 661367005321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005322 Walker A/P-loop; other site 661367005323 ATP binding site [chemical binding]; other site 661367005324 Q-loop/lid; other site 661367005325 ABC transporter signature motif; other site 661367005326 Walker B; other site 661367005327 D-loop; other site 661367005328 H-loop/switch region; other site 661367005329 Permease; Region: Permease; cl00510 661367005330 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 661367005331 homodimer interface [polypeptide binding]; other site 661367005332 NAD binding site [chemical binding]; other site 661367005333 catalytic residues [active] 661367005334 substrate binding pocket [chemical binding]; other site 661367005335 flexible flap; other site 661367005336 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 661367005337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367005338 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 661367005339 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 661367005340 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 661367005341 Cupin domain; Region: Cupin_2; cl09118 661367005342 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 661367005343 F-box domain; Region: F-box; cl02535 661367005344 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 661367005345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005346 Uncharacterized conserved protein [Function unknown]; Region: COG3496 661367005347 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 661367005348 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 661367005349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367005350 S-adenosylmethionine binding site [chemical binding]; other site 661367005351 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 661367005352 Phospholipid methyltransferase; Region: PEMT; cl00763 661367005353 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 661367005354 Fatty acid desaturase; Region: FA_desaturase; pfam00487 661367005355 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005356 Di-iron ligands [ion binding]; other site 661367005357 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005358 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 661367005359 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 661367005360 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 661367005361 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 661367005362 classical (c) SDRs; Region: SDR_c; cd05233 661367005363 NAD(P) binding site [chemical binding]; other site 661367005364 active site 661367005365 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 661367005366 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 661367005367 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367005368 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005369 hypothetical protein; Region: PHA00727 661367005370 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005371 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 661367005372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005373 Q-loop/lid; other site 661367005374 ABC transporter signature motif; other site 661367005375 Walker B; other site 661367005376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005377 Helix-turn-helix domains; Region: HTH; cl00088 661367005378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 661367005379 dimerization interface [polypeptide binding]; other site 661367005380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 661367005381 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 661367005382 Nitrogen regulatory protein P-II; Region: P-II; cl00412 661367005383 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 661367005384 Helix-turn-helix domains; Region: HTH; cl00088 661367005385 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 661367005386 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005387 ligand binding site [chemical binding]; other site 661367005388 CAAX protease self-immunity; Region: Abi; cl00558 661367005389 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 661367005390 FMN binding site [chemical binding]; other site 661367005391 active site 661367005392 substrate binding site [chemical binding]; other site 661367005393 catalytic residue [active] 661367005394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367005395 dimerization interface [polypeptide binding]; other site 661367005396 putative DNA binding site [nucleotide binding]; other site 661367005397 putative Zn2+ binding site [ion binding]; other site 661367005398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367005399 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 661367005400 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367005402 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 661367005403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 661367005404 FtsX-like permease family; Region: FtsX; cl15850 661367005405 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 661367005406 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 661367005407 Walker A/P-loop; other site 661367005408 ATP binding site [chemical binding]; other site 661367005409 Q-loop/lid; other site 661367005410 ABC transporter signature motif; other site 661367005411 Walker B; other site 661367005412 D-loop; other site 661367005413 H-loop/switch region; other site 661367005414 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 661367005415 TM2 domain; Region: TM2; cl00984 661367005416 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 661367005417 active site 661367005418 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 661367005419 putative FMN binding site [chemical binding]; other site 661367005420 NADPH bind site [chemical binding]; other site 661367005421 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367005422 DNA-binding site [nucleotide binding]; DNA binding site 661367005423 RNA-binding motif; other site 661367005424 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 661367005425 RNA/DNA binding site [nucleotide binding]; other site 661367005426 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 661367005427 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 661367005428 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 661367005429 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367005430 catalytic residue [active] 661367005431 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367005432 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367005433 Leucine-rich repeats; other site 661367005434 Substrate binding site [chemical binding]; other site 661367005435 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 661367005436 Predicted membrane protein [Function unknown]; Region: COG1971 661367005437 Domain of unknown function DUF; Region: DUF204; pfam02659 661367005438 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005439 ATP binding pocket; other site 661367005440 catalytic loop; other site 661367005441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005442 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367005443 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 661367005444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005445 TIGR01777 family protein; Region: yfcH 661367005446 NAD(P) binding site [chemical binding]; other site 661367005447 active site 661367005448 TIGR03442 family protein; Region: TIGR03442 661367005449 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 661367005450 putative active site [active] 661367005451 putative dimer interface [polypeptide binding]; other site 661367005452 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367005453 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367005454 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 661367005455 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 661367005456 inhibitor-cofactor binding pocket; inhibition site 661367005457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367005458 catalytic residue [active] 661367005459 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367005460 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367005461 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 661367005462 DNA binding residues [nucleotide binding] 661367005463 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 661367005464 dimer interface [polypeptide binding]; other site 661367005465 mercury binding site [ion binding]; other site 661367005466 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367005467 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367005468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367005469 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367005470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367005471 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367005472 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 661367005473 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 661367005474 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367005475 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 661367005476 Cache domain; Region: Cache_1; pfam02743 661367005477 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 661367005478 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 661367005479 cyclase homology domain; Region: CHD; cd07302 661367005480 nucleotidyl binding site; other site 661367005481 metal binding site [ion binding]; metal-binding site 661367005482 dimer interface [polypeptide binding]; other site 661367005483 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 661367005484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367005485 Beta-Casp domain; Region: Beta-Casp; cl12567 661367005486 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 661367005487 thymidine phosphorylase; Provisional; Region: PRK04350 661367005488 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 661367005489 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 661367005490 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 661367005491 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 661367005492 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 661367005493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367005494 active site 661367005495 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367005496 MltA specific insert domain; Region: MltA; cl08398 661367005497 3D domain; Region: 3D; cl01439 661367005498 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 661367005499 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 661367005500 catalytic site [active] 661367005501 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367005502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367005503 Coenzyme A binding pocket [chemical binding]; other site 661367005504 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 661367005505 Chromate transporter; Region: Chromate_transp; pfam02417 661367005506 Chromate transporter; Region: Chromate_transp; pfam02417 661367005507 Dot/Icm substrate protein; Region: SidE; pfam12252 661367005508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005509 Helix-turn-helix domains; Region: HTH; cl00088 661367005510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367005511 dimerization interface [polypeptide binding]; other site 661367005512 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367005513 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 661367005514 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367005515 substrate binding pocket [chemical binding]; other site 661367005516 active site 661367005517 iron coordination sites [ion binding]; other site 661367005518 hypothetical protein; Provisional; Region: PRK07190 661367005519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005521 hypothetical protein; Provisional; Region: PRK07206 661367005522 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367005523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367005524 PAS domain; Region: PAS_9; pfam13426 661367005525 putative active site [active] 661367005526 heme pocket [chemical binding]; other site 661367005527 Response regulator receiver domain; Region: Response_reg; pfam00072 661367005528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367005529 active site 661367005530 phosphorylation site [posttranslational modification] 661367005531 intermolecular recognition site; other site 661367005532 dimerization interface [polypeptide binding]; other site 661367005533 PAS fold; Region: PAS_4; pfam08448 661367005534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367005535 DNA binding residues [nucleotide binding] 661367005536 dimerization interface [polypeptide binding]; other site 661367005537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 661367005538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367005539 active site 661367005540 ATP binding site [chemical binding]; other site 661367005541 substrate binding site [chemical binding]; other site 661367005542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005543 substrate binding site [chemical binding]; other site 661367005544 activation loop (A-loop); other site 661367005545 activation loop (A-loop); other site 661367005546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005547 active site 661367005548 motif I; other site 661367005549 motif II; other site 661367005550 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 661367005551 active site 661367005552 catalytic triad [active] 661367005553 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367005554 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367005555 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 661367005556 AMP-binding enzyme; Region: AMP-binding; cl15778 661367005557 peptide synthase; Validated; Region: PRK05691 661367005558 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367005559 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367005560 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 661367005561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005562 NAD(P) binding site [chemical binding]; other site 661367005563 active site 661367005564 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 661367005565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367005566 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 661367005567 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 661367005568 probable polyamine oxidase; Region: PLN02268 661367005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005571 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 661367005572 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 661367005573 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 661367005574 PYR/PP interface [polypeptide binding]; other site 661367005575 dimer interface [polypeptide binding]; other site 661367005576 TPP binding site [chemical binding]; other site 661367005577 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 661367005578 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 661367005579 TPP-binding site; other site 661367005580 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 661367005581 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 661367005582 substrate binding site [chemical binding]; other site 661367005583 ATP binding site [chemical binding]; other site 661367005584 KduI/IolB family; Region: KduI; cl01508 661367005585 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 661367005586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005587 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 661367005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367005590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005591 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 661367005592 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 661367005593 active site 661367005594 FMN binding site [chemical binding]; other site 661367005595 substrate binding site [chemical binding]; other site 661367005596 3Fe-4S cluster binding site [ion binding]; other site 661367005597 enterobactin exporter EntS; Provisional; Region: PRK10489 661367005598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005599 putative substrate translocation pore; other site 661367005600 putative metal dependent hydrolase; Provisional; Region: PRK11598 661367005601 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 661367005602 Sulfatase; Region: Sulfatase; cl10460 661367005603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 661367005604 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 661367005605 active site 661367005606 PII uridylyl-transferase; Provisional; Region: PRK05007 661367005607 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 661367005608 metal binding triad [ion binding]; metal-binding site 661367005609 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 661367005610 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 661367005611 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 661367005612 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 661367005613 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005614 Switch II region; other site 661367005615 G4 box; other site 661367005616 G5 box; other site 661367005617 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 661367005618 nucleoside/Zn binding site; other site 661367005619 dimer interface [polypeptide binding]; other site 661367005620 catalytic motif [active] 661367005621 GMP synthase; Reviewed; Region: guaA; PRK00074 661367005622 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 661367005623 AMP/PPi binding site [chemical binding]; other site 661367005624 candidate oxyanion hole; other site 661367005625 catalytic triad [active] 661367005626 potential glutamine specificity residues [chemical binding]; other site 661367005627 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 661367005628 ATP Binding subdomain [chemical binding]; other site 661367005629 Ligand Binding sites [chemical binding]; other site 661367005630 Dimerization subdomain; other site 661367005631 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 661367005632 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 661367005633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 661367005634 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 661367005635 active site 661367005636 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 661367005637 Switch I; other site 661367005638 Switch II; other site 661367005639 Septum formation topological specificity factor MinE; Region: MinE; cl00538 661367005640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367005641 Helix-turn-helix domains; Region: HTH; cl00088 661367005642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367005643 dimerization interface [polypeptide binding]; other site 661367005644 FecR protein; Region: FecR; pfam04773 661367005645 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 661367005646 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 661367005647 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 661367005648 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 661367005649 active site 661367005650 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 661367005651 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367005652 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 661367005653 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 661367005654 Walker A/P-loop; other site 661367005655 ATP binding site [chemical binding]; other site 661367005656 Q-loop/lid; other site 661367005657 ABC transporter signature motif; other site 661367005658 Walker B; other site 661367005659 D-loop; other site 661367005660 H-loop/switch region; other site 661367005661 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 661367005662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005663 dimer interface [polypeptide binding]; other site 661367005664 conserved gate region; other site 661367005665 ABC-ATPase subunit interface; other site 661367005666 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 661367005667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005668 dimer interface [polypeptide binding]; other site 661367005669 conserved gate region; other site 661367005670 putative PBP binding loops; other site 661367005671 ABC-ATPase subunit interface; other site 661367005672 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 661367005673 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 661367005674 NAD(P) binding site [chemical binding]; other site 661367005675 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 661367005676 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 661367005677 Cl- selectivity filter; other site 661367005678 Cl- binding residues [ion binding]; other site 661367005679 pore gating glutamate residue; other site 661367005680 dimer interface [polypeptide binding]; other site 661367005681 H+/Cl- coupling transport residue; other site 661367005682 anthranilate synthase; Provisional; Region: PRK13566 661367005683 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 661367005684 chorismate binding enzyme; Region: Chorismate_bind; cl10555 661367005685 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 661367005686 glutamine binding [chemical binding]; other site 661367005687 catalytic triad [active] 661367005688 D123; Region: D123; pfam07065 661367005689 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367005690 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 661367005691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005692 motif II; other site 661367005693 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367005694 Predicted membrane protein [Function unknown]; Region: COG1289 661367005695 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 661367005696 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005697 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005698 Uncharacterized conserved protein [Function unknown]; Region: COG3268 661367005699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005700 NAD(P) binding site [chemical binding]; other site 661367005701 Lyase; Region: Lyase_1; pfam00206 661367005702 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 661367005703 active sites [active] 661367005704 tetramer interface [polypeptide binding]; other site 661367005705 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 661367005706 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 661367005707 ANP binding site [chemical binding]; other site 661367005708 Substrate Binding Site II [chemical binding]; other site 661367005709 Substrate Binding Site I [chemical binding]; other site 661367005710 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 661367005711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005712 Walker A/P-loop; other site 661367005713 ATP binding site [chemical binding]; other site 661367005714 Q-loop/lid; other site 661367005715 ABC transporter signature motif; other site 661367005716 Walker B; other site 661367005717 D-loop; other site 661367005718 H-loop/switch region; other site 661367005719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367005720 dimer interface [polypeptide binding]; other site 661367005721 conserved gate region; other site 661367005722 putative PBP binding loops; other site 661367005723 ABC-ATPase subunit interface; other site 661367005724 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367005725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367005726 substrate binding pocket [chemical binding]; other site 661367005727 membrane-bound complex binding site; other site 661367005728 hinge residues; other site 661367005729 Arginine repressor [Transcription]; Region: ArgR; COG1438 661367005730 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 661367005731 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 661367005732 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 661367005733 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367005734 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367005735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005736 Walker A/P-loop; other site 661367005737 ATP binding site [chemical binding]; other site 661367005738 Q-loop/lid; other site 661367005739 ABC transporter signature motif; other site 661367005740 Walker B; other site 661367005741 D-loop; other site 661367005742 H-loop/switch region; other site 661367005743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 661367005744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005745 ligand binding site [chemical binding]; other site 661367005746 flexible hinge region; other site 661367005747 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367005748 ligand binding site [chemical binding]; other site 661367005749 flexible hinge region; other site 661367005750 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 661367005751 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367005752 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 661367005753 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005754 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005755 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367005756 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005757 Di-iron ligands [ion binding]; other site 661367005758 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 661367005759 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 661367005760 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 661367005761 Amidase; Region: Amidase; cl11426 661367005762 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 661367005763 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 661367005764 GatB domain; Region: GatB_Yqey; cl11497 661367005765 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367005766 nucleophile elbow; other site 661367005767 Patatin phospholipase; Region: DUF3734; pfam12536 661367005768 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 661367005769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367005770 Helix-turn-helix domains; Region: HTH; cl00088 661367005771 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 661367005772 active site 661367005773 dimerization interface [polypeptide binding]; other site 661367005774 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 661367005775 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 661367005776 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367005777 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 661367005778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367005779 catalytic residue [active] 661367005780 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 661367005781 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 661367005782 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 661367005783 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 661367005784 tandem repeat interface [polypeptide binding]; other site 661367005785 oligomer interface [polypeptide binding]; other site 661367005786 active site residues [active] 661367005787 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 661367005788 Clp amino terminal domain; Region: Clp_N; pfam02861 661367005789 Clp amino terminal domain; Region: Clp_N; pfam02861 661367005790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005791 Walker A motif; other site 661367005792 ATP binding site [chemical binding]; other site 661367005793 Walker B motif; other site 661367005794 arginine finger; other site 661367005795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005796 Walker A motif; other site 661367005797 ATP binding site [chemical binding]; other site 661367005798 Walker B motif; other site 661367005799 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 661367005800 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 661367005801 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 661367005802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367005803 active site 661367005804 motif I; other site 661367005805 motif II; other site 661367005806 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 661367005807 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367005808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367005809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367005810 Predicted membrane protein [Function unknown]; Region: COG3164 661367005811 AsmA-like C-terminal region; Region: AsmA_2; cl15864 661367005812 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367005813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367005814 active site 661367005815 phosphorylation site [posttranslational modification] 661367005816 intermolecular recognition site; other site 661367005817 dimerization interface [polypeptide binding]; other site 661367005818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005819 Walker A motif; other site 661367005820 ATP binding site [chemical binding]; other site 661367005821 Walker B motif; other site 661367005822 arginine finger; other site 661367005823 Helix-turn-helix domains; Region: HTH; cl00088 661367005824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 661367005825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 661367005826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367005827 dimer interface [polypeptide binding]; other site 661367005828 phosphorylation site [posttranslational modification] 661367005829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367005830 ATP binding site [chemical binding]; other site 661367005831 Mg2+ binding site [ion binding]; other site 661367005832 G-X-G motif; other site 661367005833 recombination factor protein RarA; Reviewed; Region: PRK13342 661367005834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367005835 Walker A motif; other site 661367005836 ATP binding site [chemical binding]; other site 661367005837 Walker B motif; other site 661367005838 arginine finger; other site 661367005839 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 661367005840 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 661367005841 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 661367005842 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 661367005843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005844 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 661367005845 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 661367005846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367005847 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367005848 Src homology 2 (SH2) domain; Region: SH2; cl15255 661367005849 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 661367005850 rRNA binding site [nucleotide binding]; other site 661367005851 predicted 30S ribosome binding site; other site 661367005852 Rab GTPase; Provisional; Region: PLN03110 661367005853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367005854 G1 box; other site 661367005855 GTP/Mg2+ binding site [chemical binding]; other site 661367005856 G2 box; other site 661367005857 Switch I region; other site 661367005858 G3 box; other site 661367005859 Switch II region; other site 661367005860 G4 box; other site 661367005861 G5 box; other site 661367005862 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 661367005863 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 661367005864 dimer interface [polypeptide binding]; other site 661367005865 active site 661367005866 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 661367005867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005868 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 661367005869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 661367005870 substrate binding site [chemical binding]; other site 661367005871 oxyanion hole (OAH) forming residues; other site 661367005872 trimer interface [polypeptide binding]; other site 661367005873 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 661367005874 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367005875 tetrameric interface [polypeptide binding]; other site 661367005876 NAD binding site [chemical binding]; other site 661367005877 catalytic residues [active] 661367005878 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 661367005879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005880 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 661367005881 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 661367005882 putative active site [active] 661367005883 catalytic triad [active] 661367005884 putative dimer interface [polypeptide binding]; other site 661367005885 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 661367005886 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 661367005887 HIGH motif; other site 661367005888 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 661367005889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367005890 active site 661367005891 KMSKS motif; other site 661367005892 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 661367005893 tRNA binding surface [nucleotide binding]; other site 661367005894 Lipopolysaccharide-assembly; Region: LptE; cl01125 661367005895 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 661367005896 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 661367005897 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 661367005898 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 661367005899 active site 661367005900 (T/H)XGH motif; other site 661367005901 Colicin V production protein; Region: Colicin_V; cl00567 661367005902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 661367005903 Sporulation related domain; Region: SPOR; cl10051 661367005904 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 661367005905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367005906 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 661367005907 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367005908 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367005909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005910 putative substrate translocation pore; other site 661367005911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367005912 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 661367005913 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 661367005914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367005915 FeS/SAM binding site; other site 661367005916 TRAM domain; Region: TRAM; cl01282 661367005917 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 661367005918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367005919 RNA binding surface [nucleotide binding]; other site 661367005920 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 661367005921 active site 661367005922 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 661367005923 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 661367005924 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 661367005925 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 661367005926 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367005927 protein binding site [polypeptide binding]; other site 661367005928 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 661367005929 Cytochrome c; Region: Cytochrom_C; cl11414 661367005930 Smr domain; Region: Smr; cl02619 661367005931 Ataxin-2 C-terminal region; Region: PAM2; pfam07145 661367005932 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 661367005933 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 661367005934 nudix motif; other site 661367005935 Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015 661367005936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367005937 S-adenosylmethionine binding site [chemical binding]; other site 661367005938 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367005939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367005940 catalytic residue [active] 661367005941 Chitin binding domain; Region: Chitin_bind_3; cl03871 661367005942 Acetokinase family; Region: Acetate_kinase; cl01029 661367005943 propionate/acetate kinase; Provisional; Region: PRK12379 661367005944 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 661367005945 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 661367005946 dimer interaction site [polypeptide binding]; other site 661367005947 substrate-binding tunnel; other site 661367005948 active site 661367005949 catalytic site [active] 661367005950 substrate binding site [chemical binding]; other site 661367005951 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 661367005952 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367005953 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005954 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367005955 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367005956 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367005957 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 661367005958 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 661367005959 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367005960 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367005961 RF-1 domain; Region: RF-1; cl02875 661367005962 chaperone protein DnaJ; Provisional; Region: PRK14290 661367005963 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367005964 HSP70 interaction site [polypeptide binding]; other site 661367005965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367005966 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 661367005967 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 661367005968 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 661367005969 siderophore binding site; other site 661367005970 ParB-like nuclease domain; Region: ParBc; cl02129 661367005971 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 661367005972 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 661367005973 dimer interface [polypeptide binding]; other site 661367005974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367005975 catalytic residue [active] 661367005976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367005977 dimer interface [polypeptide binding]; other site 661367005978 ABC-ATPase subunit interface; other site 661367005979 putative PBP binding regions; other site 661367005980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367005981 ABC-ATPase subunit interface; other site 661367005982 dimer interface [polypeptide binding]; other site 661367005983 putative PBP binding regions; other site 661367005984 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 661367005985 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 661367005986 Walker A/P-loop; other site 661367005987 ATP binding site [chemical binding]; other site 661367005988 Q-loop/lid; other site 661367005989 ABC transporter signature motif; other site 661367005990 Walker B; other site 661367005991 D-loop; other site 661367005992 H-loop/switch region; other site 661367005993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367005995 putative substrate translocation pore; other site 661367005996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367005997 TMPIT-like protein; Region: TMPIT; pfam07851 661367005998 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 661367005999 Di-iron ligands [ion binding]; other site 661367006000 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 661367006001 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 661367006002 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367006003 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006004 ligand binding site [chemical binding]; other site 661367006005 potassium uptake protein; Region: kup; TIGR00794 661367006006 K+ potassium transporter; Region: K_trans; cl15781 661367006007 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367006008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006009 putative substrate translocation pore; other site 661367006010 EamA-like transporter family; Region: EamA; cl01037 661367006011 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367006012 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367006013 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 661367006014 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 661367006015 active site 661367006016 nucleophile elbow; other site 661367006017 Patatin phospholipase; Region: DUF3734; pfam12536 661367006018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420 661367006019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 661367006020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006021 dimer interface [polypeptide binding]; other site 661367006022 phosphorylation site [posttranslational modification] 661367006023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006024 ATP binding site [chemical binding]; other site 661367006025 Mg2+ binding site [ion binding]; other site 661367006026 G-X-G motif; other site 661367006027 Response regulator receiver domain; Region: Response_reg; pfam00072 661367006028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006029 active site 661367006030 phosphorylation site [posttranslational modification] 661367006031 intermolecular recognition site; other site 661367006032 dimerization interface [polypeptide binding]; other site 661367006033 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 661367006034 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 661367006035 metal binding site [ion binding]; metal-binding site 661367006036 putative dimer interface [polypeptide binding]; other site 661367006037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006038 D-galactonate transporter; Region: 2A0114; TIGR00893 661367006039 putative substrate translocation pore; other site 661367006040 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 661367006041 Helix-turn-helix domains; Region: HTH; cl00088 661367006042 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367006043 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 661367006044 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367006045 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367006046 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367006047 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 661367006048 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 661367006049 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 661367006050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367006051 G4 box; other site 661367006052 G5 box; other site 661367006053 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367006054 Ligand Binding Site [chemical binding]; other site 661367006055 Zeta toxin; Region: Zeta_toxin; pfam06414 661367006056 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 661367006057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367006058 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 661367006059 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 661367006060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 661367006061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367006062 active site 661367006063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367006064 active site 661367006065 ATP binding site [chemical binding]; other site 661367006066 substrate binding site [chemical binding]; other site 661367006067 activation loop (A-loop); other site 661367006068 High-affinity nickel-transport protein; Region: NicO; cl00964 661367006069 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 661367006070 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 661367006071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367006072 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 661367006073 Acylphosphatase; Region: Acylphosphatase; cl00551 661367006074 HypF finger; Region: zf-HYPF; pfam07503 661367006075 HypF finger; Region: zf-HYPF; pfam07503 661367006076 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 661367006077 HupF/HypC family; Region: HupF_HypC; cl00394 661367006078 Hydrogenase formation hypA family; Region: HypD; cl12072 661367006079 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 661367006080 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 661367006081 dimerization interface [polypeptide binding]; other site 661367006082 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 661367006083 ATP binding site [chemical binding]; other site 661367006084 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 661367006085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 661367006086 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 661367006087 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 661367006088 FAD binding pocket [chemical binding]; other site 661367006089 FAD binding motif [chemical binding]; other site 661367006090 phosphate binding motif [ion binding]; other site 661367006091 beta-alpha-beta structure motif; other site 661367006092 NAD binding pocket [chemical binding]; other site 661367006093 Iron coordination center [ion binding]; other site 661367006094 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 661367006095 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 661367006096 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 661367006097 nickel binding site [ion binding]; other site 661367006098 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 661367006099 Fe-S cluster binding site [ion binding]; other site 661367006100 active site 661367006101 LicD family; Region: LicD; cl01378 661367006102 Zeta toxin; Region: Zeta_toxin; pfam06414 661367006103 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 661367006104 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 661367006105 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 661367006106 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 661367006107 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367006108 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367006109 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006110 ligand binding site [chemical binding]; other site 661367006111 flexible hinge region; other site 661367006112 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 661367006113 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 661367006114 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367006115 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367006116 K+-transporting ATPase, c chain; Region: KdpC; cl00944 661367006117 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 661367006118 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 661367006119 Ligand Binding Site [chemical binding]; other site 661367006120 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 661367006121 GAF domain; Region: GAF; cl15785 661367006122 GAF domain; Region: GAF_2; pfam13185 661367006123 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 661367006124 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 661367006125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006127 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 661367006128 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 661367006129 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 661367006130 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006131 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 661367006132 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 661367006133 G1 box; other site 661367006134 putative GEF interaction site [polypeptide binding]; other site 661367006135 GTP/Mg2+ binding site [chemical binding]; other site 661367006136 Switch I region; other site 661367006137 G2 box; other site 661367006138 G3 box; other site 661367006139 Switch II region; other site 661367006140 G4 box; other site 661367006141 G5 box; other site 661367006142 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 661367006143 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 661367006144 Predicted esterase [General function prediction only]; Region: COG0627 661367006145 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367006146 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 661367006147 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 661367006148 substrate binding site [chemical binding]; other site 661367006149 catalytic Zn binding site [ion binding]; other site 661367006150 NAD binding site [chemical binding]; other site 661367006151 structural Zn binding site [ion binding]; other site 661367006152 dimer interface [polypeptide binding]; other site 661367006153 putative hydrolase; Provisional; Region: PRK10985 661367006154 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 661367006155 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 661367006156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367006157 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 661367006158 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 661367006159 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 661367006160 NAD(P) binding site [chemical binding]; other site 661367006161 catalytic residues [active] 661367006162 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 661367006163 PAS fold; Region: PAS_4; pfam08448 661367006164 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 661367006165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 661367006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006167 dimer interface [polypeptide binding]; other site 661367006168 phosphorylation site [posttranslational modification] 661367006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006170 ATP binding site [chemical binding]; other site 661367006171 Mg2+ binding site [ion binding]; other site 661367006172 G-X-G motif; other site 661367006173 Response regulator receiver domain; Region: Response_reg; pfam00072 661367006174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006175 active site 661367006176 phosphorylation site [posttranslational modification] 661367006177 intermolecular recognition site; other site 661367006178 dimerization interface [polypeptide binding]; other site 661367006179 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367006180 putative binding surface; other site 661367006181 active site 661367006182 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 661367006183 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 661367006184 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 661367006185 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367006186 Substrate binding site [chemical binding]; other site 661367006187 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 661367006188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367006189 Coenzyme A binding pocket [chemical binding]; other site 661367006190 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 661367006191 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 661367006192 E-class dimer interface [polypeptide binding]; other site 661367006193 P-class dimer interface [polypeptide binding]; other site 661367006194 active site 661367006195 Cu2+ binding site [ion binding]; other site 661367006196 Zn2+ binding site [ion binding]; other site 661367006197 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 661367006198 active site 661367006199 catalytic residues [active] 661367006200 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 661367006201 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 661367006202 oligomerization interface [polypeptide binding]; other site 661367006203 active site 661367006204 NAD+ binding site [chemical binding]; other site 661367006205 S-adenosylmethionine synthetase; Validated; Region: PRK05250 661367006206 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 661367006207 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 661367006208 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 661367006209 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 661367006210 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 661367006211 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 661367006212 catalytic site [active] 661367006213 subunit interface [polypeptide binding]; other site 661367006214 chaperone protein DnaJ; Provisional; Region: PRK10767 661367006215 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 661367006216 HSP70 interaction site [polypeptide binding]; other site 661367006217 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 661367006218 Zn binding sites [ion binding]; other site 661367006219 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 661367006220 dimer interface [polypeptide binding]; other site 661367006221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 661367006222 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 661367006223 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 661367006224 dimer interface [polypeptide binding]; other site 661367006225 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 661367006226 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 661367006227 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 661367006228 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 661367006229 substrate binding site [chemical binding]; other site 661367006230 active site 661367006231 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 661367006232 active site 661367006233 Sporulation related domain; Region: SPOR; cl10051 661367006234 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 661367006235 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 661367006236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 661367006237 active site 661367006238 HIGH motif; other site 661367006239 nucleotide binding site [chemical binding]; other site 661367006240 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 661367006241 KMSK motif region; other site 661367006242 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 661367006243 tRNA binding surface [nucleotide binding]; other site 661367006244 anticodon binding site; other site 661367006245 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 661367006246 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 661367006247 generic binding surface II; other site 661367006248 ssDNA binding site; other site 661367006249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367006250 ATP binding site [chemical binding]; other site 661367006251 putative Mg++ binding site [ion binding]; other site 661367006252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367006253 nucleotide binding region [chemical binding]; other site 661367006254 ATP-binding site [chemical binding]; other site 661367006255 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 661367006256 Cation efflux family; Region: Cation_efflux; cl00316 661367006257 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 661367006258 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 661367006259 active site 661367006260 dimer interface [polypeptide binding]; other site 661367006261 enolase; Provisional; Region: eno; PRK00077 661367006262 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 661367006263 dimer interface [polypeptide binding]; other site 661367006264 metal binding site [ion binding]; metal-binding site 661367006265 substrate binding pocket [chemical binding]; other site 661367006266 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 661367006267 nucleoside/Zn binding site; other site 661367006268 dimer interface [polypeptide binding]; other site 661367006269 catalytic motif [active] 661367006270 chromosome segregation protein; Provisional; Region: PRK03918 661367006271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 661367006272 putative DNA binding site [nucleotide binding]; other site 661367006273 dimerization interface [polypeptide binding]; other site 661367006274 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 661367006275 putative Zn2+ binding site [ion binding]; other site 661367006276 Helix-turn-helix domains; Region: HTH; cl00088 661367006277 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 661367006278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367006279 Coenzyme A binding pocket [chemical binding]; other site 661367006280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367006281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 661367006282 putative acyl-acceptor binding pocket; other site 661367006283 probable DNA repair protein; Region: TIGR03623 661367006284 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 661367006285 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 661367006286 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367006287 ligand binding site [chemical binding]; other site 661367006288 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 661367006289 aromatic amino acid transport protein; Region: araaP; TIGR00837 661367006290 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 661367006291 aromatic amino acid transport protein; Region: araaP; TIGR00837 661367006292 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 661367006293 catalytic nucleophile [active] 661367006294 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 661367006295 proposed catalytic triad [active] 661367006296 active site nucleophile [active] 661367006297 cyanophycin synthetase; Provisional; Region: PRK14016 661367006298 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367006299 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367006300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006302 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 661367006303 CsbD-like; Region: CsbD; cl15799 661367006304 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 661367006305 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 661367006306 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 661367006307 catalytic residues [active] 661367006308 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367006309 ligand binding site [chemical binding]; other site 661367006310 flexible hinge region; other site 661367006311 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 661367006312 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 661367006313 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367006314 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 661367006315 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367006316 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 661367006317 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 661367006318 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367006319 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367006320 putative dimer interface [polypeptide binding]; other site 661367006321 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 661367006322 active site clefts [active] 661367006323 zinc binding site [ion binding]; other site 661367006324 dimer interface [polypeptide binding]; other site 661367006325 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 661367006326 active site 661367006327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006328 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367006329 putative substrate translocation pore; other site 661367006330 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367006331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006333 putative substrate translocation pore; other site 661367006334 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006336 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 661367006337 putative substrate translocation pore; other site 661367006338 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 661367006339 Malic enzyme, N-terminal domain; Region: malic; pfam00390 661367006340 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 661367006341 putative NAD(P) binding site [chemical binding]; other site 661367006342 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 661367006343 Ferritin-like domain; Region: Ferritin; pfam00210 661367006344 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 661367006345 dimerization interface [polypeptide binding]; other site 661367006346 DPS ferroxidase diiron center [ion binding]; other site 661367006347 ion pore; other site 661367006348 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 661367006349 putative phosphate binding site [ion binding]; other site 661367006350 putative catalytic site [active] 661367006351 active site 661367006352 metal binding site A [ion binding]; metal-binding site 661367006353 DNA binding site [nucleotide binding] 661367006354 putative AP binding site [nucleotide binding]; other site 661367006355 putative metal binding site B [ion binding]; other site 661367006356 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 661367006357 putative active site [active] 661367006358 putative DNA binding site [nucleotide binding]; other site 661367006359 putative phosphate binding site [ion binding]; other site 661367006360 putative catalytic site [active] 661367006361 metal binding site A [ion binding]; metal-binding site 661367006362 putative AP binding site [nucleotide binding]; other site 661367006363 putative metal binding site B [ion binding]; other site 661367006364 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 661367006365 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 661367006366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006367 Walker A motif; other site 661367006368 ATP binding site [chemical binding]; other site 661367006369 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367006370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 661367006371 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 661367006372 active site 661367006373 HslU subunit interaction site [polypeptide binding]; other site 661367006374 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 661367006375 Sulfatase; Region: Sulfatase; cl10460 661367006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367006378 putative substrate translocation pore; other site 661367006379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006380 putative substrate translocation pore; other site 661367006381 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 661367006382 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 661367006383 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 661367006384 NodB motif; other site 661367006385 putative active site [active] 661367006386 putative catalytic site [active] 661367006387 putative Zn binding site [ion binding]; other site 661367006388 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367006389 Type II transport protein GspH; Region: GspH; pfam12019 661367006390 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 661367006391 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367006392 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 661367006393 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367006394 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 661367006395 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 661367006396 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 661367006397 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 661367006398 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 661367006399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 661367006400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 661367006401 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 661367006402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 661367006403 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 661367006404 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 661367006405 Walker A/P-loop; other site 661367006406 ATP binding site [chemical binding]; other site 661367006407 Q-loop/lid; other site 661367006408 ABC transporter signature motif; other site 661367006409 Walker B; other site 661367006410 D-loop; other site 661367006411 H-loop/switch region; other site 661367006412 TOBE domain; Region: TOBE_2; cl01440 661367006413 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 661367006414 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 661367006415 Competence protein; Region: Competence; cl00471 661367006416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 661367006417 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 661367006418 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 661367006419 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 661367006420 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 661367006421 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 661367006422 DNA binding site [nucleotide binding] 661367006423 active site 661367006424 Mechanosensitive ion channel; Region: MS_channel; pfam00924 661367006425 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 661367006426 heme-binding site [chemical binding]; other site 661367006427 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 661367006428 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 661367006429 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 661367006430 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 661367006431 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 661367006432 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 661367006433 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 661367006434 putative trimer interface [polypeptide binding]; other site 661367006435 putative CoA binding site [chemical binding]; other site 661367006436 GH3 auxin-responsive promoter; Region: GH3; cl04006 661367006437 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 661367006438 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 661367006439 active site 661367006440 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 661367006441 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367006442 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 661367006443 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 661367006444 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 661367006445 active site 661367006446 acyl-CoA synthetase; Validated; Region: PRK05850 661367006447 AMP-binding enzyme; Region: AMP-binding; cl15778 661367006448 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 661367006449 AMP-binding enzyme; Region: AMP-binding; cl15778 661367006450 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367006451 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367006452 classical (c) SDRs; Region: SDR_c; cd05233 661367006453 NAD(P) binding site [chemical binding]; other site 661367006454 active site 661367006455 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 661367006456 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 661367006457 dimer interface [polypeptide binding]; other site 661367006458 active site 661367006459 CoA binding pocket [chemical binding]; other site 661367006460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367006461 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367006462 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 661367006463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006464 putative substrate translocation pore; other site 661367006465 MAPEG family; Region: MAPEG; cl09190 661367006466 hypothetical protein; Validated; Region: PRK07198 661367006467 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 661367006468 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 661367006469 dimerization interface [polypeptide binding]; other site 661367006470 active site 661367006471 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 661367006472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367006473 active site 661367006474 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 661367006475 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 661367006476 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 661367006477 ParB-like nuclease domain; Region: ParBc; cl02129 661367006478 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 661367006479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367006480 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367006481 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367006482 active site 661367006483 metal binding site [ion binding]; metal-binding site 661367006484 OsmC-like protein; Region: OsmC; cl00767 661367006485 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367006486 active site 661367006487 catalytic triad [active] 661367006488 oxyanion hole [active] 661367006489 glutathione reductase; Validated; Region: PRK06116 661367006490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367006492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367006493 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 661367006494 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 661367006495 trimer interface [polypeptide binding]; other site 661367006496 putative metal binding site [ion binding]; other site 661367006497 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 661367006498 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 661367006499 active site 661367006500 HIGH motif; other site 661367006501 dimer interface [polypeptide binding]; other site 661367006502 KMSKS motif; other site 661367006503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 661367006504 RNA binding surface [nucleotide binding]; other site 661367006505 putative peptidase; Provisional; Region: PRK11649 661367006506 NADH dehydrogenase; Region: NADHdh; cl00469 661367006507 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367006508 active site residue [active] 661367006509 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 661367006510 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 661367006511 Nucleoside recognition; Region: Gate; cl00486 661367006512 Nucleoside recognition; Region: Gate; cl00486 661367006513 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 661367006514 multifunctional aminopeptidase A; Provisional; Region: PRK00913 661367006515 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 661367006516 interface (dimer of trimers) [polypeptide binding]; other site 661367006517 Substrate-binding/catalytic site; other site 661367006518 Zn-binding sites [ion binding]; other site 661367006519 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 661367006520 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 661367006521 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 661367006522 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 661367006523 interface (dimer of trimers) [polypeptide binding]; other site 661367006524 Substrate-binding/catalytic site; other site 661367006525 Zn-binding sites [ion binding]; other site 661367006526 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 661367006527 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 661367006528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 661367006529 TPR motif; other site 661367006530 binding surface 661367006531 putative transporter; Provisional; Region: PRK11660 661367006532 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367006533 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367006534 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367006535 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006536 Sel1 repeat; Region: Sel1; cl02723 661367006537 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006538 Sel1 repeat; Region: Sel1; cl02723 661367006539 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 661367006540 Sel1 repeat; Region: Sel1; cl02723 661367006541 Sel1 repeat; Region: Sel1; cl02723 661367006542 Sel1 repeat; Region: Sel1; cl02723 661367006543 Sel1 repeat; Region: Sel1; cl02723 661367006544 Sel1 repeat; Region: Sel1; cl02723 661367006545 Sel1 repeat; Region: Sel1; cl02723 661367006546 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367006547 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 661367006548 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 661367006549 GIY-YIG motif/motif A; other site 661367006550 active site 661367006551 catalytic site [active] 661367006552 putative DNA binding site [nucleotide binding]; other site 661367006553 metal binding site [ion binding]; metal-binding site 661367006554 UvrB/uvrC motif; Region: UVR; pfam02151 661367006555 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 661367006556 response regulator; Provisional; Region: PRK09483 661367006557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006558 active site 661367006559 phosphorylation site [posttranslational modification] 661367006560 intermolecular recognition site; other site 661367006561 dimerization interface [polypeptide binding]; other site 661367006562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367006563 DNA binding residues [nucleotide binding] 661367006564 dimerization interface [polypeptide binding]; other site 661367006565 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 661367006566 cofactor binding site; other site 661367006567 metal binding site [ion binding]; metal-binding site 661367006568 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367006569 Integrase core domain; Region: rve; cl01316 661367006570 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367006571 active site 661367006572 DNA polymerase IV; Validated; Region: PRK02406 661367006573 DNA binding site [nucleotide binding] 661367006574 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367006575 Catalytic site [active] 661367006576 GTPase CgtA; Reviewed; Region: obgE; PRK12299 661367006577 GTP1/OBG; Region: GTP1_OBG; pfam01018 661367006578 Obg GTPase; Region: Obg; cd01898 661367006579 G1 box; other site 661367006580 GTP/Mg2+ binding site [chemical binding]; other site 661367006581 Switch I region; other site 661367006582 G2 box; other site 661367006583 G3 box; other site 661367006584 Switch II region; other site 661367006585 G4 box; other site 661367006586 G5 box; other site 661367006587 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 661367006588 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 661367006589 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 661367006590 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 661367006591 5S rRNA interface [nucleotide binding]; other site 661367006592 CTC domain interface [polypeptide binding]; other site 661367006593 L16 interface [polypeptide binding]; other site 661367006594 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 661367006595 putative active site [active] 661367006596 catalytic residue [active] 661367006597 GTP-binding protein YchF; Reviewed; Region: PRK09601 661367006598 YchF GTPase; Region: YchF; cd01900 661367006599 G1 box; other site 661367006600 GTP/Mg2+ binding site [chemical binding]; other site 661367006601 Switch I region; other site 661367006602 G2 box; other site 661367006603 Switch II region; other site 661367006604 G3 box; other site 661367006605 G4 box; other site 661367006606 G5 box; other site 661367006607 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 661367006608 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 661367006609 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367006610 substrate binding pocket [chemical binding]; other site 661367006611 chain length determination region; other site 661367006612 substrate-Mg2+ binding site; other site 661367006613 catalytic residues [active] 661367006614 aspartate-rich region 1; other site 661367006615 active site lid residues [active] 661367006616 aspartate-rich region 2; other site 661367006617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006618 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367006619 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006620 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367006621 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367006622 active site 661367006623 Zn binding site [ion binding]; other site 661367006624 Autoinducer binding domain; Region: Autoind_bind; pfam03472 661367006625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367006626 DNA binding residues [nucleotide binding] 661367006627 dimerization interface [polypeptide binding]; other site 661367006628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006629 hypothetical protein; Validated; Region: PRK05868 661367006630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006631 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 661367006632 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 661367006633 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367006634 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 661367006635 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367006636 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367006637 ChaB; Region: ChaB; cl01887 661367006638 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 661367006639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367006640 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 661367006641 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367006642 seryl-tRNA synthetase; Provisional; Region: PRK05431 661367006643 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 661367006644 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 661367006645 dimer interface [polypeptide binding]; other site 661367006646 active site 661367006647 motif 1; other site 661367006648 motif 2; other site 661367006649 motif 3; other site 661367006650 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 661367006651 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 661367006652 active site 661367006653 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 661367006654 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 661367006655 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 661367006656 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 661367006657 trimer interface [polypeptide binding]; other site 661367006658 active site 661367006659 UDP-GlcNAc binding site [chemical binding]; other site 661367006660 lipid binding site [chemical binding]; lipid-binding site 661367006661 periplasmic chaperone; Provisional; Region: PRK10780 661367006662 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 661367006663 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 661367006664 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 661367006665 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 661367006666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 661367006667 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 661367006668 Surface antigen; Region: Bac_surface_Ag; cl03097 661367006669 zinc metallopeptidase RseP; Provisional; Region: PRK10779 661367006670 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367006671 active site 661367006672 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367006673 protein binding site [polypeptide binding]; other site 661367006674 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 661367006675 protein binding site [polypeptide binding]; other site 661367006676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 661367006677 putative substrate binding region [chemical binding]; other site 661367006678 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 661367006679 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 661367006680 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 661367006681 catalytic residue [active] 661367006682 putative FPP diphosphate binding site; other site 661367006683 putative FPP binding hydrophobic cleft; other site 661367006684 dimer interface [polypeptide binding]; other site 661367006685 putative IPP diphosphate binding site; other site 661367006686 Sulfatase; Region: Sulfatase; cl10460 661367006687 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 661367006688 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 661367006689 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 661367006690 C-terminal peptidase (prc); Region: prc; TIGR00225 661367006691 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 661367006692 protein binding site [polypeptide binding]; other site 661367006693 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 661367006694 Catalytic dyad [active] 661367006695 Peptidase family M48; Region: Peptidase_M48; cl12018 661367006696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 661367006697 Helix-turn-helix domains; Region: HTH; cl00088 661367006698 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 661367006699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367006700 active site 661367006701 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 661367006702 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 661367006703 GDP-binding site [chemical binding]; other site 661367006704 ACT binding site; other site 661367006705 IMP binding site; other site 661367006706 FtsH protease regulator HflC; Provisional; Region: PRK11029 661367006707 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 661367006708 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 661367006709 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 661367006710 HflK protein; Region: hflK; TIGR01933 661367006711 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 661367006712 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 661367006713 dimer interface [polypeptide binding]; other site 661367006714 active site 661367006715 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 661367006716 substrate binding site [chemical binding]; other site 661367006717 catalytic residue [active] 661367006718 LysE type translocator; Region: LysE; cl00565 661367006719 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367006720 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367006721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367006722 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 661367006723 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 661367006724 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 661367006725 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 661367006726 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 661367006727 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 661367006728 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 661367006729 30S subunit binding site; other site 661367006730 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 661367006731 dimerization domain swap beta strand [polypeptide binding]; other site 661367006732 regulatory protein interface [polypeptide binding]; other site 661367006733 active site 661367006734 regulatory phosphorylation site [posttranslational modification]; other site 661367006735 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 661367006736 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 661367006737 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 661367006738 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 661367006739 FAD binding pocket [chemical binding]; other site 661367006740 FAD binding motif [chemical binding]; other site 661367006741 phosphate binding motif [ion binding]; other site 661367006742 beta-alpha-beta structure motif; other site 661367006743 NAD binding pocket [chemical binding]; other site 661367006744 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 661367006745 active site 661367006746 intersubunit interface [polypeptide binding]; other site 661367006747 catalytic residue [active] 661367006748 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 661367006749 putative catalytic site [active] 661367006750 putative metal binding site [ion binding]; other site 661367006751 putative phosphate binding site [ion binding]; other site 661367006752 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 661367006753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367006754 nucleophilic elbow; other site 661367006755 catalytic triad; other site 661367006756 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 661367006757 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 661367006758 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 661367006759 active site 661367006760 Zn binding site [ion binding]; other site 661367006761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006762 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 661367006763 putative substrate translocation pore; other site 661367006764 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 661367006765 trimer interface [polypeptide binding]; other site 661367006766 active site 661367006767 dimer interface [polypeptide binding]; other site 661367006768 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 661367006769 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 661367006770 carboxyltransferase (CT) interaction site; other site 661367006771 biotinylation site [posttranslational modification]; other site 661367006772 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 661367006773 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367006774 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367006775 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 661367006776 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 661367006777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367006778 S-adenosylmethionine binding site [chemical binding]; other site 661367006779 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 661367006780 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 661367006781 purine monophosphate binding site [chemical binding]; other site 661367006782 dimer interface [polypeptide binding]; other site 661367006783 putative catalytic residues [active] 661367006784 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 661367006785 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 661367006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006787 NAD(P) binding site [chemical binding]; other site 661367006788 active site 661367006789 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 661367006790 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 661367006791 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 661367006792 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367006793 putative acyl-acceptor binding pocket; other site 661367006794 AMP-binding enzyme; Region: AMP-binding; cl15778 661367006795 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 661367006796 homodimer interface [polypeptide binding]; other site 661367006797 substrate-cofactor binding pocket; other site 661367006798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367006799 catalytic residue [active] 661367006800 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 661367006801 Nitrogen regulatory protein P-II; Region: P-II; cl00412 661367006802 Nitrogen regulatory protein P-II; Region: P-II; smart00938 661367006803 Membrane fusogenic activity; Region: BMFP; cl01115 661367006804 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 661367006805 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 661367006806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367006807 Walker A motif; other site 661367006808 ATP binding site [chemical binding]; other site 661367006809 Walker B motif; other site 661367006810 arginine finger; other site 661367006811 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 661367006812 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 661367006813 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 661367006814 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 661367006815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367006816 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 661367006817 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 661367006818 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 661367006819 Phosphate transporter family; Region: PHO4; cl00396 661367006820 Phosphate transporter family; Region: PHO4; cl00396 661367006821 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 661367006822 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 661367006823 active site 661367006824 Bacterial PH domain; Region: DUF304; cl01348 661367006825 Protein of unknown function (DUF721); Region: DUF721; cl02324 661367006826 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367006827 active site 661367006828 motif I; other site 661367006829 motif II; other site 661367006830 Uncharacterized conserved protein [Function unknown]; Region: COG4278 661367006831 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 661367006832 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 661367006833 active site 661367006834 Zn binding site [ion binding]; other site 661367006835 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 661367006836 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 661367006837 cell division protein FtsZ; Validated; Region: PRK09330 661367006838 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 661367006839 nucleotide binding site [chemical binding]; other site 661367006840 SulA interaction site; other site 661367006841 cell division protein FtsA; Region: ftsA; TIGR01174 661367006842 Cell division protein FtsA; Region: FtsA; cl11496 661367006843 Cell division protein FtsA; Region: FtsA; cl11496 661367006844 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 661367006845 Cell division protein FtsQ; Region: FtsQ; pfam03799 661367006846 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 661367006847 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 661367006848 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367006849 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 661367006850 FAD binding domain; Region: FAD_binding_4; pfam01565 661367006851 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 661367006852 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 661367006853 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367006854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006856 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 661367006857 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 661367006858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006860 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 661367006861 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 661367006862 Mg++ binding site [ion binding]; other site 661367006863 putative catalytic motif [active] 661367006864 putative substrate binding site [chemical binding]; other site 661367006865 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 661367006866 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 661367006867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 661367006868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 661367006869 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 661367006870 FtsZ protein binding site [polypeptide binding]; other site 661367006871 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367006872 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 661367006873 Walker A/P-loop; other site 661367006874 ATP binding site [chemical binding]; other site 661367006875 Q-loop/lid; other site 661367006876 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 661367006877 Q-loop/lid; other site 661367006878 ABC transporter signature motif; other site 661367006879 Walker B; other site 661367006880 D-loop; other site 661367006881 H-loop/switch region; other site 661367006882 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367006883 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 661367006884 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 661367006885 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 661367006886 PspC domain; Region: PspC; cl00864 661367006887 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 661367006888 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 661367006889 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 661367006890 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 661367006891 dimer interface [polypeptide binding]; other site 661367006892 decamer (pentamer of dimers) interface [polypeptide binding]; other site 661367006893 catalytic triad [active] 661367006894 peroxidatic and resolving cysteines [active] 661367006895 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 661367006896 Helix-turn-helix domains; Region: HTH; cl00088 661367006897 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 661367006898 dimerization interface [polypeptide binding]; other site 661367006899 T-complex protein 11; Region: Tcp11; pfam05794 661367006900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 661367006901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367006902 active site 661367006903 phosphorylation site [posttranslational modification] 661367006904 intermolecular recognition site; other site 661367006905 dimerization interface [polypeptide binding]; other site 661367006906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 661367006907 DNA binding site [nucleotide binding] 661367006908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367006909 dimer interface [polypeptide binding]; other site 661367006910 phosphorylation site [posttranslational modification] 661367006911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367006912 ATP binding site [chemical binding]; other site 661367006913 Mg2+ binding site [ion binding]; other site 661367006914 G-X-G motif; other site 661367006915 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 661367006916 AAA-like domain; Region: AAA_10; pfam12846 661367006917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 661367006918 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006919 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006920 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006921 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006922 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006923 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006924 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006925 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006926 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006927 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 661367006928 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 661367006929 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 661367006930 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367006931 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 661367006932 ligand binding site [chemical binding]; other site 661367006933 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 661367006934 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 661367006935 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 661367006936 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; cl09711 661367006937 Protein of unknown function (DUF3773); Region: DUF3773; pfam12608 661367006938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 661367006939 DNA-binding site [nucleotide binding]; DNA binding site 661367006940 RNA-binding motif; other site 661367006941 ferrochelatase; Reviewed; Region: hemH; PRK00035 661367006942 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 661367006943 C-terminal domain interface [polypeptide binding]; other site 661367006944 active site 661367006945 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 661367006946 active site 661367006947 N-terminal domain interface [polypeptide binding]; other site 661367006948 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367006949 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367006950 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 661367006951 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 661367006952 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 661367006953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006954 putative substrate translocation pore; other site 661367006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367006956 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 661367006957 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 661367006958 active site 661367006959 intersubunit interface [polypeptide binding]; other site 661367006960 catalytic residue [active] 661367006961 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 661367006962 glucokinase, proteobacterial type; Region: glk; TIGR00749 661367006963 Dehydratase family; Region: ILVD_EDD; cl00340 661367006964 6-phosphogluconate dehydratase; Region: edd; TIGR01196 661367006965 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 661367006966 putative active site [active] 661367006967 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 661367006968 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 661367006969 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 661367006970 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 661367006971 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367006972 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 661367006973 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367006974 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 661367006975 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 661367006976 Cu(I) binding site [ion binding]; other site 661367006977 UbiA prenyltransferase family; Region: UbiA; cl00337 661367006978 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 661367006979 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 661367006980 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 661367006981 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367006982 ATP binding site [chemical binding]; other site 661367006983 Mg++ binding site [ion binding]; other site 661367006984 motif III; other site 661367006985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367006986 nucleotide binding region [chemical binding]; other site 661367006987 ATP-binding site [chemical binding]; other site 661367006988 DbpA RNA binding domain; Region: DbpA; pfam03880 661367006989 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 661367006990 active site 661367006991 catalytic triad [active] 661367006992 oxyanion hole [active] 661367006993 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 661367006994 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367006995 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 661367006996 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367006997 Walker A/P-loop; other site 661367006998 ATP binding site [chemical binding]; other site 661367006999 Q-loop/lid; other site 661367007000 ABC transporter signature motif; other site 661367007001 Walker B; other site 661367007002 D-loop; other site 661367007003 H-loop/switch region; other site 661367007004 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 661367007005 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 661367007006 active site 661367007007 substrate binding site [chemical binding]; other site 661367007008 FMN binding site [chemical binding]; other site 661367007009 putative catalytic residues [active] 661367007010 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 661367007011 AMP-binding enzyme; Region: AMP-binding; cl15778 661367007012 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 661367007013 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 661367007014 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367007015 Protein of unknown function DUF45; Region: DUF45; cl00636 661367007016 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 661367007017 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 661367007018 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 661367007019 RimM N-terminal domain; Region: RimM; pfam01782 661367007020 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 661367007021 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 661367007022 signal recognition particle protein; Provisional; Region: PRK10867 661367007023 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 661367007024 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 661367007025 P loop; other site 661367007026 GTP binding site [chemical binding]; other site 661367007027 Signal peptide binding domain; Region: SRP_SPB; pfam02978 661367007028 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 661367007029 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 661367007030 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 661367007031 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 661367007032 active site 661367007033 FMN binding site [chemical binding]; other site 661367007034 2,4-decadienoyl-CoA binding site; other site 661367007035 catalytic residue [active] 661367007036 4Fe-4S cluster binding site [ion binding]; other site 661367007037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007038 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 661367007039 EamA-like transporter family; Region: EamA; cl01037 661367007040 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 661367007041 malate dehydrogenase; Provisional; Region: PRK05442 661367007042 NAD(P) binding site [chemical binding]; other site 661367007043 dimer interface [polypeptide binding]; other site 661367007044 malate binding site [chemical binding]; other site 661367007045 HemN family oxidoreductase; Provisional; Region: PRK05660 661367007046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 661367007047 FeS/SAM binding site; other site 661367007048 HemN C-terminal domain; Region: HemN_C; pfam06969 661367007049 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 661367007050 UGMP family protein; Validated; Region: PRK09604 661367007051 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 661367007052 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 661367007053 GatB domain; Region: GatB_Yqey; cl11497 661367007054 DNA primase; Validated; Region: dnaG; PRK05667 661367007055 CHC2 zinc finger; Region: zf-CHC2; cl15369 661367007056 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 661367007057 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 661367007058 active site 661367007059 metal binding site [ion binding]; metal-binding site 661367007060 interdomain interaction site; other site 661367007061 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 661367007062 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 661367007063 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 661367007064 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 661367007065 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 661367007066 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 661367007067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 661367007068 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 661367007069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 661367007070 DNA binding residues [nucleotide binding] 661367007071 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 661367007072 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367007073 DNA binding site [nucleotide binding] 661367007074 Int/Topo IB signature motif; other site 661367007075 active site 661367007076 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 661367007077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367007078 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 661367007079 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 661367007080 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 661367007081 HsdM N-terminal domain; Region: HsdM_N; pfam12161 661367007082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007083 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 661367007084 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 661367007085 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 661367007086 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 661367007087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367007088 ATP binding site [chemical binding]; other site 661367007089 putative Mg++ binding site [ion binding]; other site 661367007090 AAA domain; Region: AAA_13; pfam13166 661367007091 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 661367007092 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 661367007093 active site 661367007094 metal binding site [ion binding]; metal-binding site 661367007095 DNA binding site [nucleotide binding] 661367007096 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 661367007097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007098 Walker A/P-loop; other site 661367007099 ATP binding site [chemical binding]; other site 661367007100 Q-loop/lid; other site 661367007101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007102 non-specific DNA binding site [nucleotide binding]; other site 661367007103 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 661367007104 salt bridge; other site 661367007105 sequence-specific DNA binding site [nucleotide binding]; other site 661367007106 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367007107 Catalytic site [active] 661367007108 Global regulator protein family; Region: CsrA; cl00670 661367007109 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 661367007110 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 661367007111 ATP binding site [chemical binding]; other site 661367007112 Walker A motif; other site 661367007113 hexamer interface [polypeptide binding]; other site 661367007114 Walker B motif; other site 661367007115 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007116 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007117 TrbC/VIRB2 family; Region: TrbC; cl01583 661367007118 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 661367007119 conjugal transfer protein TrbE; Provisional; Region: PRK13891 661367007120 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 661367007121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007122 Walker A motif; other site 661367007123 ATP binding site [chemical binding]; other site 661367007124 VirB8 protein; Region: VirB8; cl01500 661367007125 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 661367007126 VirB7 interaction site; other site 661367007127 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 661367007128 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 661367007129 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 661367007130 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 661367007131 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 661367007132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007133 Walker A motif; other site 661367007134 ATP binding site [chemical binding]; other site 661367007135 Walker B motif; other site 661367007136 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 661367007137 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 661367007138 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 661367007139 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 661367007140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 661367007141 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 661367007142 active site 661367007143 metal binding site [ion binding]; metal-binding site 661367007144 interdomain interaction site; other site 661367007145 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 661367007146 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 661367007147 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 661367007148 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 661367007149 P-loop; other site 661367007150 Transcriptional activator TraM; Region: Activator-TraM; cl11943 661367007151 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 661367007152 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 661367007153 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367007154 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 661367007155 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39C; cd02419 661367007156 putative active site [active] 661367007157 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 661367007158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007159 Walker A/P-loop; other site 661367007160 ATP binding site [chemical binding]; other site 661367007161 Q-loop/lid; other site 661367007162 ABC transporter signature motif; other site 661367007163 Walker B; other site 661367007164 D-loop; other site 661367007165 H-loop/switch region; other site 661367007166 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 661367007167 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367007168 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367007169 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 661367007170 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007171 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007172 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 661367007173 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007174 Walker A/P-loop; other site 661367007175 ATP binding site [chemical binding]; other site 661367007176 Q-loop/lid; other site 661367007177 ABC transporter signature motif; other site 661367007178 Walker B; other site 661367007179 D-loop; other site 661367007180 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367007181 Transposase; Region: DEDD_Tnp_IS110; pfam01548 661367007182 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 661367007183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007184 salt bridge; other site 661367007185 non-specific DNA binding site [nucleotide binding]; other site 661367007186 sequence-specific DNA binding site [nucleotide binding]; other site 661367007187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367007188 Catalytic site [active] 661367007189 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 661367007190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007191 ATP binding site [chemical binding]; other site 661367007192 substrate interface [chemical binding]; other site 661367007193 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 661367007194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367007196 putative substrate translocation pore; other site 661367007197 aconitate hydratase; Validated; Region: PRK09277 661367007198 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 661367007199 substrate binding site [chemical binding]; other site 661367007200 ligand binding site [chemical binding]; other site 661367007201 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 661367007202 substrate binding site [chemical binding]; other site 661367007203 Protein of unknown function, DUF488; Region: DUF488; cl01246 661367007204 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 661367007205 FAD binding pocket [chemical binding]; other site 661367007206 conserved FAD binding motif [chemical binding]; other site 661367007207 phosphate binding motif [ion binding]; other site 661367007208 beta-alpha-beta structure motif; other site 661367007209 NAD binding pocket [chemical binding]; other site 661367007210 OsmC-like protein; Region: OsmC; cl00767 661367007211 Protein of unknown function, DUF488; Region: DUF488; cl01246 661367007212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007213 Ligand Binding Site [chemical binding]; other site 661367007214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007215 Ligand Binding Site [chemical binding]; other site 661367007216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007217 Ligand Binding Site [chemical binding]; other site 661367007218 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007219 Ligand Binding Site [chemical binding]; other site 661367007220 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367007221 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 661367007222 putative dimer interface [polypeptide binding]; other site 661367007223 N-terminal domain interface [polypeptide binding]; other site 661367007224 putative substrate binding pocket (H-site) [chemical binding]; other site 661367007225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007226 Ligand Binding Site [chemical binding]; other site 661367007227 putative cation:proton antiport protein; Provisional; Region: PRK10669 661367007228 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367007229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007230 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 661367007231 putative active site [active] 661367007232 metal binding site [ion binding]; metal-binding site 661367007233 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 661367007234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 661367007235 Transposase; Region: DDE_Tnp_ISL3; pfam01610 661367007236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007237 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 661367007238 Domain of unknown function (DUF927); Region: DUF927; cl12098 661367007239 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 661367007240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007241 AAA domain; Region: AAA_22; pfam13401 661367007242 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 661367007243 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 661367007244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 661367007245 active site 661367007246 metal binding site [ion binding]; metal-binding site 661367007247 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 661367007248 Helix-turn-helix domains; Region: HTH; cl00088 661367007249 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367007250 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367007251 DNA binding site [nucleotide binding] 661367007252 Int/Topo IB signature motif; other site 661367007253 active site 661367007254 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 661367007255 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 661367007256 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007257 Ligand Binding Site [chemical binding]; other site 661367007258 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367007259 Ligand Binding Site [chemical binding]; other site 661367007260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 661367007261 non-specific DNA binding site [nucleotide binding]; other site 661367007262 salt bridge; other site 661367007263 sequence-specific DNA binding site [nucleotide binding]; other site 661367007264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 661367007265 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 661367007266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007267 putative substrate translocation pore; other site 661367007268 acyl-CoA synthetase; Validated; Region: PRK09192 661367007269 AMP-binding enzyme; Region: AMP-binding; cl15778 661367007270 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 661367007271 putative acyl-acceptor binding pocket; other site 661367007272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 661367007273 ABC-ATPase subunit interface; other site 661367007274 dimer interface [polypeptide binding]; other site 661367007275 putative PBP binding regions; other site 661367007276 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 661367007277 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007278 Walker A/P-loop; other site 661367007279 ATP binding site [chemical binding]; other site 661367007280 Q-loop/lid; other site 661367007281 ABC transporter signature motif; other site 661367007282 Walker B; other site 661367007283 D-loop; other site 661367007284 H-loop/switch region; other site 661367007285 Predicted membrane protein [Function unknown]; Region: COG3174 661367007286 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 661367007287 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 661367007288 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367007289 putative dimer interface [polypeptide binding]; other site 661367007290 mercuric reductase; Validated; Region: PRK06370 661367007291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 661367007292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 661367007293 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 661367007294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367007295 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367007296 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 661367007297 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 661367007298 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367007299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 661367007300 catalytic core [active] 661367007301 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367007302 substrate binding site [chemical binding]; other site 661367007303 activation loop (A-loop); other site 661367007304 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 661367007305 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 661367007306 hypothetical protein; Provisional; Region: PRK05713 661367007307 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 661367007308 catalytic loop [active] 661367007309 iron binding site [ion binding]; other site 661367007310 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 661367007311 FAD binding pocket [chemical binding]; other site 661367007312 FAD binding motif [chemical binding]; other site 661367007313 phosphate binding motif [ion binding]; other site 661367007314 beta-alpha-beta structure motif; other site 661367007315 NAD binding pocket [chemical binding]; other site 661367007316 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 661367007317 apolar tunnel; other site 661367007318 heme binding site [chemical binding]; other site 661367007319 dimerization interface [polypeptide binding]; other site 661367007320 Helix-turn-helix domains; Region: HTH; cl00088 661367007321 Rrf2 family protein; Region: rrf2_super; TIGR00738 661367007322 amino acid transporter; Region: 2A0306; TIGR00909 661367007323 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 661367007324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 661367007325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367007326 catalytic residue [active] 661367007327 MarC family integral membrane protein; Region: MarC; cl00919 661367007328 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 661367007329 peptidase domain interface [polypeptide binding]; other site 661367007330 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 661367007331 active site 661367007332 catalytic triad [active] 661367007333 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 661367007334 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 661367007335 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 661367007336 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 661367007337 active site 661367007338 substrate binding site [chemical binding]; other site 661367007339 cosubstrate binding site; other site 661367007340 catalytic site [active] 661367007341 Cupin domain; Region: Cupin_2; cl09118 661367007342 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 661367007343 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 661367007344 classical (c) SDRs; Region: SDR_c; cd05233 661367007345 NAD(P) binding site [chemical binding]; other site 661367007346 active site 661367007347 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367007348 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 661367007349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367007350 Walker A/P-loop; other site 661367007351 ATP binding site [chemical binding]; other site 661367007352 Q-loop/lid; other site 661367007353 ABC transporter signature motif; other site 661367007354 Walker B; other site 661367007355 D-loop; other site 661367007356 H-loop/switch region; other site 661367007357 ABC transporter; Region: ABC_tran_2; pfam12848 661367007358 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 661367007359 DDE superfamily endonuclease; Region: DDE_5; cl02413 661367007360 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 661367007361 Repeats found in Drosophila proteins; Region: DM9; smart00696 661367007362 FkbH-like domain; Region: FkbH; TIGR01686 661367007363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 661367007364 active site 661367007365 motif I; other site 661367007366 motif II; other site 661367007367 short chain dehydrogenase; Provisional; Region: PRK06180 661367007368 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 661367007369 NADP binding site [chemical binding]; other site 661367007370 active site 661367007371 steroid binding site; other site 661367007372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367007373 Helix-turn-helix domains; Region: HTH; cl00088 661367007374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367007375 dimerization interface [polypeptide binding]; other site 661367007376 ornithine carbamoyltransferase; Provisional; Region: PRK00779 661367007377 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 661367007378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007379 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367007380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367007381 substrate binding pocket [chemical binding]; other site 661367007382 membrane-bound complex binding site; other site 661367007383 hinge residues; other site 661367007384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 661367007385 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 661367007386 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 661367007387 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 661367007388 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 661367007389 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 661367007390 putative active site [active] 661367007391 putative catalytic site [active] 661367007392 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 661367007393 TIGR03442 family protein; Region: TIGR03442 661367007394 putative active site [active] 661367007395 putative dimer interface [polypeptide binding]; other site 661367007396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 661367007397 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367007398 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 661367007399 FAD binding domain; Region: FAD_binding_4; pfam01565 661367007400 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 661367007401 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 661367007402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007404 PAS fold; Region: PAS_7; pfam12860 661367007405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007406 PAS domain; Region: PAS_9; pfam13426 661367007407 putative active site [active] 661367007408 heme pocket [chemical binding]; other site 661367007409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007410 metal binding site [ion binding]; metal-binding site 661367007411 active site 661367007412 I-site; other site 661367007413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367007414 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 661367007415 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 661367007416 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 661367007417 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 661367007418 putative NADH binding site [chemical binding]; other site 661367007419 putative active site [active] 661367007420 nudix motif; other site 661367007421 putative metal binding site [ion binding]; other site 661367007422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 661367007423 LysE type translocator; Region: LysE; cl00565 661367007424 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 661367007425 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 661367007426 Catalytic domain of Protein Kinases; Region: PKc; cd00180 661367007427 active site 661367007428 ATP binding site [chemical binding]; other site 661367007429 substrate binding site [chemical binding]; other site 661367007430 activation loop (A-loop); other site 661367007431 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 661367007432 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 661367007433 Ligand binding site; other site 661367007434 Putative Catalytic site; other site 661367007435 DXD motif; other site 661367007436 GtrA-like protein; Region: GtrA; cl00971 661367007437 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 661367007438 CrcB-like protein; Region: CRCB; cl09114 661367007439 YdjC-like protein; Region: YdjC; cl01344 661367007440 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 661367007441 EamA-like transporter family; Region: EamA; cl01037 661367007442 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 661367007443 active site 661367007444 dimerization interface [polypeptide binding]; other site 661367007445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007446 Tetratricopeptide repeat; Region: TPR_16; pfam13432 661367007447 binding surface 661367007448 TPR motif; other site 661367007449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007450 binding surface 661367007451 TPR motif; other site 661367007452 TPR repeat; Region: TPR_11; pfam13414 661367007453 TPR repeat; Region: TPR_11; pfam13414 661367007454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007455 binding surface 661367007456 TPR motif; other site 661367007457 TPR repeat; Region: TPR_11; pfam13414 661367007458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007459 binding surface 661367007460 TPR motif; other site 661367007461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 661367007462 binding surface 661367007463 TPR motif; other site 661367007464 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 661367007465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007466 PAS fold; Region: PAS_4; pfam08448 661367007467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 661367007468 DNA binding residues [nucleotide binding] 661367007469 dimerization interface [polypeptide binding]; other site 661367007470 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367007471 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007473 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 661367007474 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 661367007475 active site 661367007476 substrate binding site [chemical binding]; other site 661367007477 metal binding site [ion binding]; metal-binding site 661367007478 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 661367007479 trimer interface [polypeptide binding]; other site 661367007480 active site 661367007481 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 661367007482 Flavoprotein; Region: Flavoprotein; cl08021 661367007483 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 661367007484 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 661367007485 MPN+ (JAMM) motif; other site 661367007486 Zinc-binding site [ion binding]; other site 661367007487 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 661367007488 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 661367007489 motif 1; other site 661367007490 dimer interface [polypeptide binding]; other site 661367007491 active site 661367007492 motif 2; other site 661367007493 motif 3; other site 661367007494 Domain of unknown function DUF59; Region: DUF59; cl00941 661367007495 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 661367007496 trimerization site [polypeptide binding]; other site 661367007497 active site 661367007498 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 661367007499 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 661367007500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 661367007501 catalytic residue [active] 661367007502 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 661367007503 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 661367007504 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 661367007505 FeS assembly ATPase SufC; Region: sufC; TIGR01978 661367007506 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 661367007507 Walker A/P-loop; other site 661367007508 ATP binding site [chemical binding]; other site 661367007509 Q-loop/lid; other site 661367007510 ABC transporter signature motif; other site 661367007511 Walker B; other site 661367007512 D-loop; other site 661367007513 H-loop/switch region; other site 661367007514 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 661367007515 putative ABC transporter; Region: ycf24; CHL00085 661367007516 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 661367007517 Helix-turn-helix domains; Region: HTH; cl00088 661367007518 Helix-turn-helix domains; Region: HTH; cl00088 661367007519 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 661367007520 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 661367007521 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 661367007522 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 661367007523 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 661367007524 Tim44-like domain; Region: Tim44; cl09208 661367007525 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367007526 active site 661367007527 nucleophile elbow; other site 661367007528 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367007529 Mitochondrial carrier protein; Region: Mito_carr; pfam00153 661367007530 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367007531 putative binding surface; other site 661367007532 active site 661367007533 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367007534 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007536 active site 661367007537 phosphorylation site [posttranslational modification] 661367007538 intermolecular recognition site; other site 661367007539 dimerization interface [polypeptide binding]; other site 661367007540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007541 metal binding site [ion binding]; metal-binding site 661367007542 active site 661367007543 I-site; other site 661367007544 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007546 active site 661367007547 phosphorylation site [posttranslational modification] 661367007548 intermolecular recognition site; other site 661367007549 dimerization interface [polypeptide binding]; other site 661367007550 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 661367007551 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007552 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007553 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 661367007554 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 661367007555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007556 putative active site [active] 661367007557 heme pocket [chemical binding]; other site 661367007558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367007559 dimer interface [polypeptide binding]; other site 661367007560 phosphorylation site [posttranslational modification] 661367007561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367007562 ATP binding site [chemical binding]; other site 661367007563 Mg2+ binding site [ion binding]; other site 661367007564 G-X-G motif; other site 661367007565 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007567 active site 661367007568 phosphorylation site [posttranslational modification] 661367007569 intermolecular recognition site; other site 661367007570 dimerization interface [polypeptide binding]; other site 661367007571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007572 active site 661367007573 phosphorylation site [posttranslational modification] 661367007574 intermolecular recognition site; other site 661367007575 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 661367007576 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 661367007577 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 661367007578 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 661367007579 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367007580 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367007581 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 661367007582 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 661367007583 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367007584 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 661367007585 IMP binding site; other site 661367007586 dimer interface [polypeptide binding]; other site 661367007587 interdomain contacts; other site 661367007588 partial ornithine binding site; other site 661367007589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007590 HI0933-like protein; Region: HI0933_like; pfam03486 661367007591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007592 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007593 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007594 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 661367007595 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007596 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367007597 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007598 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367007599 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007600 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367007601 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367007602 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 661367007603 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 661367007604 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007605 Dot/Icm substrate protein; Region: SidE; pfam12252 661367007606 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 661367007607 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 661367007608 active site 661367007609 purine riboside binding site [chemical binding]; other site 661367007610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367007611 FAD binding domain; Region: FAD_binding_3; pfam01494 661367007612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007614 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 661367007615 amidase catalytic site [active] 661367007616 Zn binding residues [ion binding]; other site 661367007617 substrate binding site [chemical binding]; other site 661367007618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367007619 Helix-turn-helix domains; Region: HTH; cl00088 661367007620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 661367007621 dimerization interface [polypeptide binding]; other site 661367007622 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 661367007623 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 661367007624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 661367007625 Walker A motif; other site 661367007626 ATP binding site [chemical binding]; other site 661367007627 Walker B motif; other site 661367007628 arginine finger; other site 661367007629 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 661367007630 PQ loop repeat; Region: PQ-loop; cl12056 661367007631 Thiamine pyrophosphokinase; Region: TPK; cd07995 661367007632 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 661367007633 active site 661367007634 dimerization interface [polypeptide binding]; other site 661367007635 thiamine binding site [chemical binding]; other site 661367007636 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 661367007637 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 661367007638 ArsC family; Region: ArsC; pfam03960 661367007639 catalytic residues [active] 661367007640 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367007641 Leucine-rich repeats; other site 661367007642 Substrate binding site [chemical binding]; other site 661367007643 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 661367007644 Leucine-rich repeats; other site 661367007645 Substrate binding site [chemical binding]; other site 661367007646 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 661367007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007648 putative substrate translocation pore; other site 661367007649 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 661367007650 MltA specific insert domain; Region: MltA; cl08398 661367007651 3D domain; Region: 3D; cl01439 661367007652 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 661367007653 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 661367007654 putative NAD(P) binding site [chemical binding]; other site 661367007655 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 661367007656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007657 active site 661367007658 phosphorylation site [posttranslational modification] 661367007659 intermolecular recognition site; other site 661367007660 dimerization interface [polypeptide binding]; other site 661367007661 PAS domain S-box; Region: sensory_box; TIGR00229 661367007662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 661367007663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007664 metal binding site [ion binding]; metal-binding site 661367007665 active site 661367007666 I-site; other site 661367007667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367007668 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 661367007669 aromatic acid decarboxylase; Validated; Region: PRK05920 661367007670 Flavoprotein; Region: Flavoprotein; cl08021 661367007671 IucA / IucC family; Region: IucA_IucC; pfam04183 661367007672 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 661367007673 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367007674 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 661367007675 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 661367007676 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367007677 Y-family of DNA polymerases; Region: PolY; cl12025 661367007678 acetolactate synthase; Reviewed; Region: PRK08322 661367007679 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 661367007680 PYR/PP interface [polypeptide binding]; other site 661367007681 dimer interface [polypeptide binding]; other site 661367007682 TPP binding site [chemical binding]; other site 661367007683 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 661367007684 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 661367007685 TPP-binding site [chemical binding]; other site 661367007686 dimer interface [polypeptide binding]; other site 661367007687 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367007688 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 661367007689 NAD(P) binding site [chemical binding]; other site 661367007690 catalytic residues [active] 661367007691 Glutaminase; Region: Glutaminase; cl00907 661367007692 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 661367007693 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 661367007694 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 661367007695 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 661367007696 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 661367007697 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 661367007698 Substrate binding site; other site 661367007699 Cupin domain; Region: Cupin_2; cl09118 661367007700 polysaccharide export protein Wza; Provisional; Region: PRK15078 661367007701 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 661367007702 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 661367007703 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 661367007704 Walker A/P-loop; other site 661367007705 ATP binding site [chemical binding]; other site 661367007706 Q-loop/lid; other site 661367007707 ABC transporter signature motif; other site 661367007708 Walker B; other site 661367007709 D-loop; other site 661367007710 H-loop/switch region; other site 661367007711 ABC-2 type transporter; Region: ABC2_membrane; cl11417 661367007712 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 661367007713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 661367007714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367007715 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 661367007716 putative ADP-binding pocket [chemical binding]; other site 661367007717 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 661367007718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007719 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 661367007720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007721 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 661367007722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007723 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 661367007724 Protein of unknown function (DUF972); Region: DUF972; pfam06156 661367007725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007726 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 661367007727 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 661367007728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 661367007729 active site 661367007730 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 661367007731 ligand binding site; other site 661367007732 tetramer interface; other site 661367007733 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 661367007734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007735 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 661367007736 classical (c) SDRs; Region: SDR_c; cd05233 661367007737 NAD(P) binding site [chemical binding]; other site 661367007738 active site 661367007739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 661367007740 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 661367007741 UDP-glucose 4-epimerase; Region: PLN02240 661367007742 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 661367007743 NAD binding site [chemical binding]; other site 661367007744 homodimer interface [polypeptide binding]; other site 661367007745 active site 661367007746 substrate binding site [chemical binding]; other site 661367007747 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 661367007748 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 661367007749 NADP-binding site; other site 661367007750 homotetramer interface [polypeptide binding]; other site 661367007751 substrate binding site [chemical binding]; other site 661367007752 homodimer interface [polypeptide binding]; other site 661367007753 active site 661367007754 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 661367007755 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 661367007756 active site 661367007757 tetramer interface; other site 661367007758 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 661367007759 UDP-glucose 4-epimerase; Region: PLN02240 661367007760 NAD binding site [chemical binding]; other site 661367007761 homodimer interface [polypeptide binding]; other site 661367007762 active site 661367007763 substrate binding site [chemical binding]; other site 661367007764 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 661367007765 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 661367007766 NADP binding site [chemical binding]; other site 661367007767 active site 661367007768 putative substrate binding site [chemical binding]; other site 661367007769 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 661367007770 metal-binding site 661367007771 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 661367007772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007773 NAD(P) binding site [chemical binding]; other site 661367007774 active site 661367007775 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 661367007776 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 661367007777 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 661367007778 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 661367007779 substrate-cofactor binding pocket; other site 661367007780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367007781 catalytic residue [active] 661367007782 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367007783 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 661367007784 active site 661367007785 Acyl transferase domain; Region: Acyl_transf_1; cl08282 661367007786 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 661367007787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007788 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 661367007789 Enoylreductase; Region: PKS_ER; smart00829 661367007790 NAD(P) binding site [chemical binding]; other site 661367007791 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 661367007792 putative NADP binding site [chemical binding]; other site 661367007793 active site 661367007794 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367007795 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 661367007796 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 661367007797 putative NAD(P) binding site [chemical binding]; other site 661367007798 active site 661367007799 putative substrate binding site [chemical binding]; other site 661367007800 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 661367007801 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 661367007802 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 661367007803 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 661367007804 Response regulator receiver domain; Region: Response_reg; pfam00072 661367007805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367007806 active site 661367007807 phosphorylation site [posttranslational modification] 661367007808 intermolecular recognition site; other site 661367007809 dimerization interface [polypeptide binding]; other site 661367007810 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 661367007811 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 661367007812 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367007813 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367007814 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367007815 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 661367007816 Uncharacterized conserved protein [Function unknown]; Region: COG2128 661367007817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007818 metabolite-proton symporter; Region: 2A0106; TIGR00883 661367007819 putative substrate translocation pore; other site 661367007820 gamma-glutamyl kinase; Provisional; Region: PRK05429 661367007821 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 661367007822 nucleotide binding site [chemical binding]; other site 661367007823 homotetrameric interface [polypeptide binding]; other site 661367007824 putative phosphate binding site [ion binding]; other site 661367007825 putative allosteric binding site; other site 661367007826 PUA domain; Region: PUA; cl00607 661367007827 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 661367007828 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 661367007829 putative catalytic cysteine [active] 661367007830 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 661367007831 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367007832 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 661367007833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007834 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 661367007835 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367007836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367007837 Helix-turn-helix domains; Region: HTH; cl00088 661367007838 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 661367007839 putative effector binding pocket; other site 661367007840 dimerization interface [polypeptide binding]; other site 661367007841 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 661367007842 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367007843 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367007844 TIGR03440 family protein; Region: unchr_TIGR03440 661367007845 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 661367007846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367007847 S-adenosylmethionine binding site [chemical binding]; other site 661367007848 Maf-like protein; Region: Maf; pfam02545 661367007849 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 661367007850 active site 661367007851 dimer interface [polypeptide binding]; other site 661367007852 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 661367007853 active site 661367007854 nucleophile elbow; other site 661367007855 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 661367007856 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 661367007857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367007858 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367007859 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 661367007860 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 661367007861 active site 661367007862 dimer interface [polypeptide binding]; other site 661367007863 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 661367007864 Ligand Binding Site [chemical binding]; other site 661367007865 Molecular Tunnel; other site 661367007866 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367007867 ArsC family; Region: ArsC; pfam03960 661367007868 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 661367007869 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 661367007870 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 661367007871 transmembrane helices; other site 661367007872 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 661367007873 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 661367007874 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 661367007875 active site 661367007876 NTP binding site [chemical binding]; other site 661367007877 metal binding triad [ion binding]; metal-binding site 661367007878 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 661367007879 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 661367007880 putative dimer interface [polypeptide binding]; other site 661367007881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007882 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 661367007883 Domain of unknown function (DUF296); Region: DUF296; cl00720 661367007884 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 661367007885 transmembrane helices; other site 661367007886 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 661367007887 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 661367007888 transmembrane helices; other site 661367007889 Cupin domain; Region: Cupin_2; cl09118 661367007890 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 661367007891 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 661367007892 Helix-turn-helix domains; Region: HTH; cl00088 661367007893 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 661367007894 putative dimerization interface [polypeptide binding]; other site 661367007895 LrgA family; Region: LrgA; cl00608 661367007896 LrgB-like family; Region: LrgB; cl00596 661367007897 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 661367007898 Cation efflux family; Region: Cation_efflux; cl00316 661367007899 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 661367007900 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 661367007901 ATP binding site [chemical binding]; other site 661367007902 Mg++ binding site [ion binding]; other site 661367007903 motif III; other site 661367007904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367007905 nucleotide binding region [chemical binding]; other site 661367007906 ATP-binding site [chemical binding]; other site 661367007907 DbpA RNA binding domain; Region: DbpA; pfam03880 661367007908 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 661367007909 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 661367007910 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 661367007911 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 661367007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367007913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367007914 putative substrate translocation pore; other site 661367007915 PAS domain S-box; Region: sensory_box; TIGR00229 661367007916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007917 putative active site [active] 661367007918 heme pocket [chemical binding]; other site 661367007919 PAS domain S-box; Region: sensory_box; TIGR00229 661367007920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367007921 putative active site [active] 661367007922 heme pocket [chemical binding]; other site 661367007923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367007924 metal binding site [ion binding]; metal-binding site 661367007925 active site 661367007926 I-site; other site 661367007927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367007928 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 661367007929 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 661367007930 active site 661367007931 nucleophile elbow; other site 661367007932 Uncharacterized conserved protein [Function unknown]; Region: COG2128 661367007933 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 661367007934 Family description; Region: VCBS; pfam13517 661367007935 Family description; Region: VCBS; pfam13517 661367007936 Family description; Region: VCBS; pfam13517 661367007937 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 661367007938 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 661367007939 active site 661367007940 Zn binding site [ion binding]; other site 661367007941 transketolase; Reviewed; Region: PRK12753 661367007942 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 661367007943 TPP-binding site [chemical binding]; other site 661367007944 dimer interface [polypeptide binding]; other site 661367007945 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 661367007946 PYR/PP interface [polypeptide binding]; other site 661367007947 dimer interface [polypeptide binding]; other site 661367007948 TPP binding site [chemical binding]; other site 661367007949 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 661367007950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007951 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 661367007952 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 661367007953 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 661367007954 Phosphoglycerate kinase; Region: PGK; pfam00162 661367007955 substrate binding site [chemical binding]; other site 661367007956 hinge regions; other site 661367007957 ADP binding site [chemical binding]; other site 661367007958 catalytic site [active] 661367007959 pyruvate kinase; Provisional; Region: PRK05826 661367007960 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 661367007961 domain interfaces; other site 661367007962 active site 661367007963 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 661367007964 putative RNA binding sites [nucleotide binding]; other site 661367007965 dihydrodipicolinate reductase; Provisional; Region: PRK00048 661367007966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007967 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 661367007968 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 661367007969 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 661367007970 tetrameric interface [polypeptide binding]; other site 661367007971 NAD binding site [chemical binding]; other site 661367007972 catalytic residues [active] 661367007973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367007974 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 661367007975 acetyl-CoA synthetase; Provisional; Region: PRK00174 661367007976 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 661367007977 AMP-binding enzyme; Region: AMP-binding; cl15778 661367007978 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 661367007979 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 661367007980 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 661367007981 dimerization interface [polypeptide binding]; other site 661367007982 ATP binding site [chemical binding]; other site 661367007983 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 661367007984 dimerization interface [polypeptide binding]; other site 661367007985 ATP binding site [chemical binding]; other site 661367007986 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 661367007987 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 661367007988 dimerization interface [polypeptide binding]; other site 661367007989 putative ATP binding site [chemical binding]; other site 661367007990 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 661367007991 conserved cys residue [active] 661367007992 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 661367007993 active site 661367007994 ATP binding site [chemical binding]; other site 661367007995 substrate binding site [chemical binding]; other site 661367007996 amidophosphoribosyltransferase; Provisional; Region: PRK09246 661367007997 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 661367007998 active site 661367007999 tetramer interface [polypeptide binding]; other site 661367008000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 661367008001 active site 661367008002 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 661367008003 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 661367008004 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367008005 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 661367008006 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 661367008007 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 661367008008 active site 661367008009 substrate binding site [chemical binding]; other site 661367008010 cosubstrate binding site; other site 661367008011 catalytic site [active] 661367008012 AIR carboxylase; Region: AIRC; cl00310 661367008013 Fic/DOC family; Region: Fic; cl00960 661367008014 high affinity sulphate transporter 1; Region: sulP; TIGR00815 661367008015 Sulfate transporter family; Region: Sulfate_transp; cl15842 661367008016 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 661367008017 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367008018 ligand binding site [chemical binding]; other site 661367008019 flexible hinge region; other site 661367008020 Predicted GTPase [General function prediction only]; Region: COG0218 661367008021 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 661367008022 G1 box; other site 661367008023 GTP/Mg2+ binding site [chemical binding]; other site 661367008024 Switch I region; other site 661367008025 G2 box; other site 661367008026 G3 box; other site 661367008027 Switch II region; other site 661367008028 G4 box; other site 661367008029 G5 box; other site 661367008030 Cytochrome c; Region: Cytochrom_C; cl11414 661367008031 Cytochrome c; Region: Cytochrom_C; cl11414 661367008032 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 661367008033 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 661367008034 catalytic residues [active] 661367008035 hinge region; other site 661367008036 alpha helical domain; other site 661367008037 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 661367008038 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 661367008039 Rab subfamily motif 1 (RabSF1); other site 661367008040 G1 box; other site 661367008041 GTP/Mg2+ binding site [chemical binding]; other site 661367008042 Rab subfamily motif 2 (RabSF2); other site 661367008043 Switch I region; other site 661367008044 G2 box; other site 661367008045 effector interaction site; other site 661367008046 GDI interaction site; other site 661367008047 Rab family motif 1 (RabF1); other site 661367008048 GEF interaction site [polypeptide binding]; other site 661367008049 Rab family motif 2 (RabF2); other site 661367008050 G3 box; other site 661367008051 Switch II region; other site 661367008052 Rab family motif 3 (RabF3); other site 661367008053 Rab family motif 4 (RabF4); other site 661367008054 Rab family motif 5 (RabF5); other site 661367008055 Rab subfamily motif 3 (RabSF3); other site 661367008056 G4 box; other site 661367008057 G5 box; other site 661367008058 Rab subfamily motif 4 (RabSF4); other site 661367008059 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 661367008060 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 661367008061 Walker A/P-loop; other site 661367008062 ATP binding site [chemical binding]; other site 661367008063 Q-loop/lid; other site 661367008064 ABC transporter signature motif; other site 661367008065 Walker B; other site 661367008066 D-loop; other site 661367008067 H-loop/switch region; other site 661367008068 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 661367008069 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 661367008070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 661367008071 dimer interface [polypeptide binding]; other site 661367008072 conserved gate region; other site 661367008073 putative PBP binding loops; other site 661367008074 ABC-ATPase subunit interface; other site 661367008075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 661367008076 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 661367008077 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 661367008078 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 661367008079 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 661367008080 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 661367008081 lipoyl attachment site [posttranslational modification]; other site 661367008082 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 661367008083 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 661367008084 tetramer interface [polypeptide binding]; other site 661367008085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008086 catalytic residue [active] 661367008087 YCII-related domain; Region: YCII; cl00999 661367008088 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 661367008089 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 661367008090 tetramer interface [polypeptide binding]; other site 661367008091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008092 catalytic residue [active] 661367008093 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 661367008094 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 661367008095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008096 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 661367008097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367008098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 661367008099 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 661367008100 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 661367008101 dimer interface [polypeptide binding]; other site 661367008102 putative CheW interface [polypeptide binding]; other site 661367008103 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 661367008104 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367008105 putative binding surface; other site 661367008106 active site 661367008107 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 661367008108 putative binding surface; other site 661367008109 active site 661367008110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008111 ATP binding site [chemical binding]; other site 661367008112 Mg2+ binding site [ion binding]; other site 661367008113 G-X-G motif; other site 661367008114 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 661367008115 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 661367008116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008117 active site 661367008118 phosphorylation site [posttranslational modification] 661367008119 intermolecular recognition site; other site 661367008120 dimerization interface [polypeptide binding]; other site 661367008121 CheB methylesterase; Region: CheB_methylest; pfam01339 661367008122 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008124 active site 661367008125 phosphorylation site [posttranslational modification] 661367008126 intermolecular recognition site; other site 661367008127 dimerization interface [polypeptide binding]; other site 661367008128 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 661367008129 cyclase homology domain; Region: CHD; cd07302 661367008130 nucleotidyl binding site; other site 661367008131 metal binding site [ion binding]; metal-binding site 661367008132 dimer interface [polypeptide binding]; other site 661367008133 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 661367008134 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 661367008135 oligomer interface [polypeptide binding]; other site 661367008136 active site 661367008137 metal binding site [ion binding]; metal-binding site 661367008138 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 661367008139 Ligand binding site; other site 661367008140 oligomer interface; other site 661367008141 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 661367008142 catalytic core [active] 661367008143 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 661367008144 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 661367008145 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367008146 Predicted acetyltransferase [General function prediction only]; Region: COG3153 661367008147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367008148 Coenzyme A binding pocket [chemical binding]; other site 661367008149 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 661367008150 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 661367008151 dimer interface [polypeptide binding]; other site 661367008152 active site 661367008153 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 661367008154 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 661367008155 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 661367008156 trimer interface [polypeptide binding]; other site 661367008157 active site 661367008158 UDP-GlcNAc binding site [chemical binding]; other site 661367008159 lipid binding site [chemical binding]; lipid-binding site 661367008160 DNA polymerase I; Provisional; Region: PRK05755 661367008161 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 661367008162 active site 661367008163 metal binding site 1 [ion binding]; metal-binding site 661367008164 putative 5' ssDNA interaction site; other site 661367008165 metal binding site 3; metal-binding site 661367008166 metal binding site 2 [ion binding]; metal-binding site 661367008167 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 661367008168 putative DNA binding site [nucleotide binding]; other site 661367008169 putative metal binding site [ion binding]; other site 661367008170 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 661367008171 active site 661367008172 catalytic site [active] 661367008173 substrate binding site [chemical binding]; other site 661367008174 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 661367008175 active site 661367008176 DNA binding site [nucleotide binding] 661367008177 catalytic site [active] 661367008178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008179 active site 661367008180 phosphorylation site [posttranslational modification] 661367008181 intermolecular recognition site; other site 661367008182 dimerization interface [polypeptide binding]; other site 661367008183 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008185 active site 661367008186 phosphorylation site [posttranslational modification] 661367008187 intermolecular recognition site; other site 661367008188 dimerization interface [polypeptide binding]; other site 661367008189 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 661367008190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367008191 putative active site [active] 661367008192 heme pocket [chemical binding]; other site 661367008193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367008194 dimer interface [polypeptide binding]; other site 661367008195 phosphorylation site [posttranslational modification] 661367008196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008197 ATP binding site [chemical binding]; other site 661367008198 Mg2+ binding site [ion binding]; other site 661367008199 G-X-G motif; other site 661367008200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008201 active site 661367008202 phosphorylation site [posttranslational modification] 661367008203 intermolecular recognition site; other site 661367008204 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367008205 HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244 661367008206 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 661367008207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 661367008208 active site 661367008209 dimer interface [polypeptide binding]; other site 661367008210 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 661367008211 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 661367008212 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 661367008213 ribonuclease R; Region: RNase_R; TIGR02063 661367008214 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367008215 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 661367008216 RNB domain; Region: RNB; pfam00773 661367008217 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 661367008218 RNA binding site [nucleotide binding]; other site 661367008219 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008221 substrate binding pocket [chemical binding]; other site 661367008222 membrane-bound complex binding site; other site 661367008223 hinge residues; other site 661367008224 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008226 substrate binding pocket [chemical binding]; other site 661367008227 membrane-bound complex binding site; other site 661367008228 hinge residues; other site 661367008229 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 661367008230 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 661367008231 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 661367008232 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 661367008233 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367008234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008235 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 661367008236 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 661367008237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008238 proline aminopeptidase P II; Provisional; Region: PRK10879 661367008239 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 661367008240 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 661367008241 active site 661367008242 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 661367008243 Cell division protein ZapA; Region: ZapA; cl01146 661367008244 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 661367008245 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 661367008246 active site 661367008247 FMN binding site [chemical binding]; other site 661367008248 substrate binding site [chemical binding]; other site 661367008249 3Fe-4S cluster binding site [ion binding]; other site 661367008250 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 661367008251 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 661367008252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008253 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008254 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 661367008255 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 661367008256 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 661367008257 substrate binding pocket [chemical binding]; other site 661367008258 chain length determination region; other site 661367008259 substrate-Mg2+ binding site; other site 661367008260 catalytic residues [active] 661367008261 aspartate-rich region 1; other site 661367008262 active site lid residues [active] 661367008263 aspartate-rich region 2; other site 661367008264 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 661367008265 putative catalytic residue [active] 661367008266 excinuclease ABC subunit B; Provisional; Region: PRK05298 661367008267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367008268 ATP binding site [chemical binding]; other site 661367008269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367008270 nucleotide binding region [chemical binding]; other site 661367008271 ATP-binding site [chemical binding]; other site 661367008272 Ultra-violet resistance protein B; Region: UvrB; pfam12344 661367008273 UvrB/uvrC motif; Region: UVR; pfam02151 661367008274 aspartate aminotransferase; Provisional; Region: PRK05764 661367008275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 661367008276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 661367008277 homodimer interface [polypeptide binding]; other site 661367008278 catalytic residue [active] 661367008279 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367008280 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 661367008281 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008282 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008283 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008284 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008285 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008286 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008287 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008288 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008289 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008290 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008291 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 661367008292 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 661367008293 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 661367008294 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 661367008295 DNA binding site [nucleotide binding] 661367008296 active site 661367008297 Int/Topo IB signature motif; other site 661367008298 catalytic residues [active] 661367008299 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 661367008300 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 661367008301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 661367008302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008303 putative substrate translocation pore; other site 661367008304 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 661367008305 active site 661367008306 iron coordination sites [ion binding]; other site 661367008307 substrate binding pocket [chemical binding]; other site 661367008308 Flavin Reductases; Region: FlaRed; cl00801 661367008309 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 661367008310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 661367008311 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367008312 putative transporter; Provisional; Region: PRK10054 661367008313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 661367008314 putative substrate translocation pore; other site 661367008315 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 661367008316 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 661367008317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 661367008318 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 661367008319 DNA binding site [nucleotide binding] 661367008320 Int/Topo IB signature motif; other site 661367008321 active site 661367008322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 661367008323 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367008324 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 661367008325 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 661367008326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367008327 S-adenosylmethionine binding site [chemical binding]; other site 661367008328 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008329 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008330 substrate binding pocket [chemical binding]; other site 661367008331 membrane-bound complex binding site; other site 661367008332 hinge residues; other site 661367008333 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 661367008334 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 661367008335 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 661367008336 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 661367008337 active site 661367008338 catalytic site [active] 661367008339 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367008340 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 661367008341 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367008342 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367008343 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367008344 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 661367008345 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 661367008346 C-terminal domain interface [polypeptide binding]; other site 661367008347 GSH binding site (G-site) [chemical binding]; other site 661367008348 dimer interface [polypeptide binding]; other site 661367008349 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 661367008350 N-terminal domain interface [polypeptide binding]; other site 661367008351 dimer interface [polypeptide binding]; other site 661367008352 substrate binding pocket (H-site) [chemical binding]; other site 661367008353 ATP-dependent helicase HepA; Validated; Region: PRK04914 661367008354 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 661367008355 ATP binding site [chemical binding]; other site 661367008356 putative Mg++ binding site [ion binding]; other site 661367008357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 661367008358 nucleotide binding region [chemical binding]; other site 661367008359 ATP-binding site [chemical binding]; other site 661367008360 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 661367008361 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 661367008362 iron-sulfur cluster [ion binding]; other site 661367008363 [2Fe-2S] cluster binding site [ion binding]; other site 661367008364 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 661367008365 putative deacylase active site [active] 661367008366 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367008367 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 661367008368 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 661367008369 Dot/Icm substrate protein; Region: SidE; pfam12252 661367008370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008371 metal binding site [ion binding]; metal-binding site 661367008372 active site 661367008373 I-site; other site 661367008374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 661367008375 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 661367008376 putative active site [active] 661367008377 putative NTP binding site [chemical binding]; other site 661367008378 putative nucleic acid binding site [nucleotide binding]; other site 661367008379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 661367008380 ligand binding site [chemical binding]; other site 661367008381 flexible hinge region; other site 661367008382 CAAX protease self-immunity; Region: Abi; cl00558 661367008383 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 661367008384 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 661367008385 putative active site [active] 661367008386 Zn binding site [ion binding]; other site 661367008387 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 661367008388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 661367008389 S-adenosylmethionine binding site [chemical binding]; other site 661367008390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 661367008391 Helix-turn-helix domains; Region: HTH; cl00088 661367008392 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 661367008393 substrate binding pocket [chemical binding]; other site 661367008394 dimerization interface [polypeptide binding]; other site 661367008395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008396 TIGR01777 family protein; Region: yfcH 661367008397 NAD(P) binding site [chemical binding]; other site 661367008398 active site 661367008399 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 661367008400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008401 NAD(P) binding pocket [chemical binding]; other site 661367008402 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 661367008403 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 661367008404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008405 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 661367008406 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 661367008407 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 661367008408 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367008409 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 661367008410 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 661367008411 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 661367008412 CAP-like domain; other site 661367008413 active site 661367008414 primary dimer interface [polypeptide binding]; other site 661367008415 CHASE3 domain; Region: CHASE3; cl05000 661367008416 PAS fold; Region: PAS_4; pfam08448 661367008417 GAF domain; Region: GAF_2; pfam13185 661367008418 GAF domain; Region: GAF; cl15785 661367008419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008420 metal binding site [ion binding]; metal-binding site 661367008421 active site 661367008422 I-site; other site 661367008423 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 661367008424 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 661367008425 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 661367008426 E3 interaction surface; other site 661367008427 lipoyl attachment site [posttranslational modification]; other site 661367008428 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 661367008429 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 661367008430 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 661367008431 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 661367008432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 661367008433 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 661367008434 alpha subunit interaction interface [polypeptide binding]; other site 661367008435 Walker A motif; other site 661367008436 ATP binding site [chemical binding]; other site 661367008437 Walker B motif; other site 661367008438 inhibitor binding site; inhibition site 661367008439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 661367008440 ATP synthase; Region: ATP-synt; cl00365 661367008441 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 661367008442 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 661367008443 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 661367008444 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 661367008445 beta subunit interaction interface [polypeptide binding]; other site 661367008446 Walker A motif; other site 661367008447 ATP binding site [chemical binding]; other site 661367008448 Walker B motif; other site 661367008449 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 661367008450 Plant ATP synthase F0; Region: YMF19; cl07975 661367008451 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 661367008452 Plant ATP synthase F0; Region: YMF19; cl07975 661367008453 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 661367008454 ATP synthase subunit C; Region: ATP-synt_C; cl00466 661367008455 ATP synthase A chain; Region: ATP-synt_A; cl00413 661367008456 ATP synthase I chain; Region: ATP_synt_I; cl09170 661367008457 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 661367008458 dimer interface [polypeptide binding]; other site 661367008459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367008460 active site 661367008461 metal binding site [ion binding]; metal-binding site 661367008462 glutathione binding site [chemical binding]; other site 661367008463 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 661367008464 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 661367008465 outer membrane lipoprotein; Provisional; Region: PRK11023 661367008466 BON domain; Region: BON; cl02771 661367008467 BON domain; Region: BON; cl02771 661367008468 BON domain; Region: BON; cl02771 661367008469 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 661367008470 dimer interface [polypeptide binding]; other site 661367008471 active site 661367008472 Restriction endonuclease; Region: Mrr_cat; cl00516 661367008473 LppC putative lipoprotein; Region: LppC; pfam04348 661367008474 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 661367008475 putative ligand binding site [chemical binding]; other site 661367008476 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 661367008477 Predicted methyltransferases [General function prediction only]; Region: COG0313 661367008478 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 661367008479 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 661367008480 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 661367008481 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 661367008482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 661367008483 dimer interface [polypeptide binding]; other site 661367008484 phosphorylation site [posttranslational modification] 661367008485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 661367008486 ATP binding site [chemical binding]; other site 661367008487 Mg2+ binding site [ion binding]; other site 661367008488 G-X-G motif; other site 661367008489 Response regulator receiver domain; Region: Response_reg; pfam00072 661367008490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 661367008491 active site 661367008492 phosphorylation site [posttranslational modification] 661367008493 intermolecular recognition site; other site 661367008494 dimerization interface [polypeptide binding]; other site 661367008495 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 661367008496 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 661367008497 AMP-binding enzyme; Region: AMP-binding; cl15778 661367008498 AMP-binding enzyme; Region: AMP-binding; cl15778 661367008499 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367008500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 661367008501 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 661367008502 active site 661367008503 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 661367008504 Acyl transferase domain; Region: Acyl_transf_1; cl08282 661367008505 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 661367008506 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 661367008507 putative NADP binding site [chemical binding]; other site 661367008508 active site 661367008509 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 661367008510 Phosphopantetheine attachment site; Region: PP-binding; cl09936 661367008511 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 661367008512 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 661367008513 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 661367008514 trmE is a tRNA modification GTPase; Region: trmE; cd04164 661367008515 G1 box; other site 661367008516 GTP/Mg2+ binding site [chemical binding]; other site 661367008517 Switch I region; other site 661367008518 G2 box; other site 661367008519 Switch II region; other site 661367008520 G3 box; other site 661367008521 G4 box; other site 661367008522 G5 box; other site 661367008523 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 661367008524 membrane protein insertase; Provisional; Region: PRK01318 661367008525 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 661367008526 Haemolytic domain; Region: Haemolytic; cl00506 661367008527 Ribonuclease P; Region: Ribonuclease_P; cl00457 661367008528 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 661367008529 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 661367008530 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367008531 P-loop; other site 661367008532 Magnesium ion binding site [ion binding]; other site 661367008533 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 661367008534 Magnesium ion binding site [ion binding]; other site 661367008535 ParB-like nuclease domain; Region: ParBc; cl02129 661367008536 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 661367008537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 661367008538 ATP-grasp domain; Region: ATP-grasp_4; cl03087 661367008539 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 661367008540 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 661367008541 ATP binding site [chemical binding]; other site 661367008542 substrate interface [chemical binding]; other site 661367008543 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 661367008544 active site residue [active] 661367008545 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 661367008546 YcaO-like family; Region: YcaO; pfam02624 661367008547 TfuA-like protein; Region: TfuA; pfam07812 661367008548 TraA; Region: TraA; cl11503 661367008549 TraL protein; Region: TraL; cl06278 661367008550 TraE protein; Region: TraE; cl05060 661367008551 TraK protein; Region: TraK; pfam06586 661367008552 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 661367008553 YebO-like protein; Region: YebO; pfam13974 661367008554 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 661367008555 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 661367008556 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 661367008557 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515 661367008558 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 661367008559 TraU protein; Region: TraU; cl06067 661367008560 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 661367008561 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 661367008562 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367008563 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 661367008564 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 661367008565 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 661367008566 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 661367008567 F sex factor protein N terminal; Region: TraD_N; pfam12615 661367008568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367008569 Walker A motif; other site 661367008570 ATP binding site [chemical binding]; other site 661367008571 Walker B motif; other site 661367008572 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 661367008573 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 661367008574 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 661367008575 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 661367008576 Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624 661367008577 Domain of unknown function (DUF932); Region: DUF932; cl12129 661367008578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 661367008579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 661367008580 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 661367008581 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 661367008582 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 661367008583 catalytic residues [active] 661367008584 catalytic nucleophile [active] 661367008585 Presynaptic Site I dimer interface [polypeptide binding]; other site 661367008586 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 661367008587 Synaptic Flat tetramer interface [polypeptide binding]; other site 661367008588 Synaptic Site I dimer interface [polypeptide binding]; other site 661367008589 DNA binding site [nucleotide binding] 661367008590 Helix-turn-helix domains; Region: HTH; cl00088 661367008591 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 661367008592 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 661367008593 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 661367008594 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 661367008595 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 661367008596 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 661367008597 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 661367008598 universal stress protein UspE; Provisional; Region: PRK11175 661367008599 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 661367008600 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 661367008601 Ligand Binding Site [chemical binding]; other site 661367008602 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 661367008603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 661367008604 NAD(P) binding site [chemical binding]; other site 661367008605 active site 661367008606 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 661367008607 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 661367008608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 661367008609 substrate binding pocket [chemical binding]; other site 661367008610 membrane-bound complex binding site; other site 661367008611 hinge residues; other site 661367008612 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 661367008613 equals pllo0049b; putative transposase (partial) 661367008614 equals pllo0049a; putative transposase (partial) 661367008615 equals pllo0050; putative transposase (partial) 661367008616 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 661367008617 IHF dimer interface [polypeptide binding]; other site 661367008618 IHF - DNA interface [nucleotide binding]; other site 661367008619 equals pllo0052; putative single-stranded DNA-binding protein 661367008620 equals pllo0053; putative exonuclease (C-terminal part) 661367008621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 661367008622 Helix-turn-helix domains; Region: HTH; cl00088 661367008623 PAS domain S-box; Region: sensory_box; TIGR00229 661367008624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 661367008625 putative active site [active] 661367008626 heme pocket [chemical binding]; other site 661367008627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 661367008628 metal binding site [ion binding]; metal-binding site 661367008629 active site 661367008630 I-site; other site 661367008631 Transposase; Region: HTH_Tnp_IS630; pfam01710 661367008632 equals pllo0057; putative transposase (N-terminal part) 661367008633 equals pllo0058; putative transposase (C-terminal part) 661367008634 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 661367008635 dimer interface [polypeptide binding]; other site 661367008636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 661367008637 metal binding site [ion binding]; metal-binding site 661367008638 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 661367008639 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 661367008640 active site 661367008641 substrate binding site [chemical binding]; other site 661367008642 catalytic site [active] 661367008643 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 661367008644 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 661367008645 Helix-turn-helix domains; Region: HTH; cl00088 661367008646 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 661367008647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 661367008648 Coenzyme A binding pocket [chemical binding]; other site 661367008649 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 661367008650 active site 661367008651 DNA polymerase IV; Validated; Region: PRK02406 661367008652 DNA binding site [nucleotide binding] 661367008653 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 661367008654 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 661367008655 active site 661367008656 DNA binding site [nucleotide binding] 661367008657 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 661367008658 SOS regulatory protein LexA; Region: lexA; TIGR00498 661367008659 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 661367008660 Catalytic site [active] 661367008661 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 661367008662 DNA-specific endonuclease I; Provisional; Region: PRK15137 661367008663 Endonuclease I; Region: Endonuclease_1; cl01003 661367008664 equals pllo0069; hypothetical protein (truncated) 661367008665 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346