-- dump date   	20120504_151551
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
297246000001	ParB-like nuclease domain; Region: ParBc; cl02129
297246000002	ParB-like partition proteins; Region: parB_part; TIGR00180
297246000003	Helix-turn-helix domains; Region: HTH; cl00088
297246000004	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
297246000005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
297246000006	P-loop; other site
297246000007	Magnesium ion binding site [ion binding]; other site
297246000008	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
297246000009	Magnesium ion binding site [ion binding]; other site
297246000010	ParB-like partition proteins; Region: parB_part; TIGR00180
297246000011	ParB-like nuclease domain; Region: ParBc; cl02129
297246000012	Initiator Replication protein; Region: Rep_3; cl03080
297246000013	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
297246000014	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246000015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246000016	Helix-turn-helix domains; Region: HTH; cl00088
297246000017	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246000018	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
297246000019	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
297246000020	ATP binding site [chemical binding]; other site
297246000021	substrate interface [chemical binding]; other site
297246000022	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
297246000023	active site residue [active]
297246000024	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
297246000025	YcaO-like family; Region: YcaO; pfam02624
297246000026	TfuA-like protein; Region: TfuA; pfam07812
297246000027	Global regulator protein family; Region: CsrA; cl00670
297246000028	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
297246000029	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
297246000030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
297246000031	Helix-turn-helix domains; Region: HTH; cl00088
297246000032	Integrase core domain; Region: rve; cl01316
297246000033	transposase/IS protein; Provisional; Region: PRK09183
297246000034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246000035	Walker A motif; other site
297246000036	ATP binding site [chemical binding]; other site
297246000037	Walker B motif; other site
297246000038	TraA; Region: TraA; cl11503
297246000039	TraL protein; Region: TraL; cl06278
297246000040	TraE protein; Region: TraE; cl05060
297246000041	TraK protein; Region: TraK; pfam06586
297246000042	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
297246000043	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
297246000044	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
297246000045	Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515
297246000046	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
297246000047	TraU protein; Region: TraU; cl06067
297246000048	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
297246000049	type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750
297246000050	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
297246000051	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
297246000052	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
297246000053	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
297246000054	Sodium:solute symporter family; Region: SSF; cl00456
297246000055	type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759
297246000056	F sex factor protein N terminal; Region: TraD_N; pfam12615
297246000057	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000058	Walker A motif; other site
297246000059	ATP binding site [chemical binding]; other site
297246000060	Walker B motif; other site
297246000061	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
297246000062	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
297246000063	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000064	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
297246000065	Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624
297246000066	Antirestriction protein; Region: Antirestrict; pfam03230
297246000067	Abi-like protein; Region: Abi_2; cl01988
297246000068	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
297246000069	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
297246000070	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
297246000071	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
297246000072	catalytic residues [active]
297246000073	catalytic nucleophile [active]
297246000074	Presynaptic Site I dimer interface [polypeptide binding]; other site
297246000075	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
297246000076	Synaptic Flat tetramer interface [polypeptide binding]; other site
297246000077	Synaptic Site I dimer interface [polypeptide binding]; other site
297246000078	DNA binding site [nucleotide binding]
297246000079	Helix-turn-helix domains; Region: HTH; cl00088
297246000080	DNA-binding interface [nucleotide binding]; DNA binding site
297246000081	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
297246000082	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
297246000083	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
297246000084	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246000085	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246000086	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
297246000087	Walker A/P-loop; other site
297246000088	ATP binding site [chemical binding]; other site
297246000089	Q-loop/lid; other site
297246000090	ABC transporter signature motif; other site
297246000091	Walker B; other site
297246000092	D-loop; other site
297246000093	H-loop/switch region; other site
297246000094	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
297246000095	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
297246000096	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246000097	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
297246000098	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246000099	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246000100	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246000101	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000102	Walker A/P-loop; other site
297246000103	ATP binding site [chemical binding]; other site
297246000104	Q-loop/lid; other site
297246000105	ABC transporter signature motif; other site
297246000106	Walker B; other site
297246000107	D-loop; other site
297246000108	H-loop/switch region; other site
297246000109	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
297246000110	active site
297246000111	NTP binding site [chemical binding]; other site
297246000112	metal binding triad [ion binding]; metal-binding site
297246000113	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
297246000114	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
297246000115	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000117	Coenzyme A binding pocket [chemical binding]; other site
297246000118	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000119	Coenzyme A binding pocket [chemical binding]; other site
297246000120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000121	Coenzyme A binding pocket [chemical binding]; other site
297246000122	N-acetylglutamate synthase; Validated; Region: PRK05279
297246000123	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
297246000124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000125	AAA domain; Region: AAA_28; pfam13521
297246000126	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
297246000127	DNA binding residues [nucleotide binding]
297246000128	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
297246000129	dimer interface [polypeptide binding]; other site
297246000130	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
297246000131	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246000132	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246000133	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246000134	Helix-turn-helix domains; Region: HTH; cl00088
297246000135	BlaR1 peptidase M56; Region: Peptidase_M56; cl15829
297246000136	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246000137	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246000138	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
297246000139	NodB motif; other site
297246000140	putative active site [active]
297246000141	putative catalytic site [active]
297246000142	putative Zn binding site [ion binding]; other site
297246000143	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246000144	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246000145	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
297246000146	active site
297246000147	metal binding site [ion binding]; metal-binding site
297246000148	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
297246000149	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
297246000150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246000151	S-adenosylmethionine binding site [chemical binding]; other site
297246000152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000153	Coenzyme A binding pocket [chemical binding]; other site
297246000154	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
297246000155	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
297246000156	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
297246000157	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
297246000158	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246000159	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
297246000160	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
297246000161	DNA binding residues [nucleotide binding]
297246000162	dimer interface [polypeptide binding]; other site
297246000163	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
297246000164	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
297246000165	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
297246000166	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
297246000167	aminoglycoside resistance protein; Provisional; Region: PRK13746
297246000168	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
297246000169	HEPN domain; Region: HEPN; cl00824
297246000170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
297246000171	dimerization interface [polypeptide binding]; other site
297246000172	putative DNA binding site [nucleotide binding]; other site
297246000173	putative Zn2+ binding site [ion binding]; other site
297246000174	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
297246000175	active site
297246000176	NTP binding site [chemical binding]; other site
297246000177	metal binding triad [ion binding]; metal-binding site
297246000178	antibiotic binding site [chemical binding]; other site
297246000179	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246000180	cyanophycin synthetase; Provisional; Region: PRK14016
297246000181	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
297246000182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246000183	active site
297246000184	phosphorylation site [posttranslational modification]
297246000185	intermolecular recognition site; other site
297246000186	dimerization interface [polypeptide binding]; other site
297246000187	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
297246000188	DNA binding site [nucleotide binding]
297246000189	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246000190	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246000191	sensor protein RstB; Provisional; Region: PRK10604
297246000192	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246000193	dimer interface [polypeptide binding]; other site
297246000194	phosphorylation site [posttranslational modification]
297246000195	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246000196	ATP binding site [chemical binding]; other site
297246000197	Mg2+ binding site [ion binding]; other site
297246000198	G-X-G motif; other site
297246000199	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
297246000200	active site
297246000201	NTP binding site [chemical binding]; other site
297246000202	metal binding triad [ion binding]; metal-binding site
297246000203	antibiotic binding site [chemical binding]; other site
297246000204	Cupin domain; Region: Cupin_2; cl09118
297246000205	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
297246000206	Phosphotransferase enzyme family; Region: APH; pfam01636
297246000207	Helix-turn-helix domains; Region: HTH; cl00088
297246000208	WYL domain; Region: WYL; cl14852
297246000209	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
297246000210	putative dimer interface [polypeptide binding]; other site
297246000211	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246000212	EVE domain; Region: EVE; cl00728
297246000213	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
297246000214	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
297246000215	A new structural DNA glycosylase; Region: AlkD_like; cd06561
297246000216	active site
297246000217	Phosphotransferase enzyme family; Region: APH; pfam01636
297246000218	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000219	C-terminal part similar to acetyltransferase;hypothetical protein
297246000220	LysE type translocator; Region: LysE; cl00565
297246000221	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246000222	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000223	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368
297246000224	Zn binding site [ion binding]; other site
297246000225	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
297246000226	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246000227	Putative esterase; Region: Esterase; pfam00756
297246000228	shikimate kinase; Reviewed; Region: aroK; PRK00131
297246000229	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
297246000230	ADP binding site [chemical binding]; other site
297246000231	magnesium binding site [ion binding]; other site
297246000232	putative shikimate binding site; other site
297246000233	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246000234	DNA binding residues [nucleotide binding]
297246000235	dimerization interface [polypeptide binding]; other site
297246000236	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246000237	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
297246000238	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155
297246000239	putative active site [active]
297246000240	putative substrate binding site [chemical binding]; other site
297246000241	ATP binding site [chemical binding]; other site
297246000242	Phosphotransferase enzyme family; Region: APH; pfam01636
297246000243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000245	Coenzyme A binding pocket [chemical binding]; other site
297246000246	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
297246000247	classical (c) SDRs; Region: SDR_c; cd05233
297246000248	NAD(P) binding site [chemical binding]; other site
297246000249	active site
297246000250	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000251	Cupin domain; Region: Cupin_2; cl09118
297246000252	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
297246000253	dimer interface [polypeptide binding]; other site
297246000254	catalytic triad [active]
297246000255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000256	Coenzyme A binding pocket [chemical binding]; other site
297246000257	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000258	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
297246000259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246000260	S-adenosylmethionine binding site [chemical binding]; other site
297246000261	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000262	Coenzyme A binding pocket [chemical binding]; other site
297246000263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
297246000264	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
297246000265	active site
297246000266	NTP binding site [chemical binding]; other site
297246000267	metal binding triad [ion binding]; metal-binding site
297246000268	antibiotic binding site [chemical binding]; other site
297246000269	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
297246000270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000271	Coenzyme A binding pocket [chemical binding]; other site
297246000272	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
297246000273	DNA binding residues [nucleotide binding]
297246000274	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
297246000275	dimer interface [polypeptide binding]; other site
297246000276	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000277	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
297246000278	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
297246000279	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
297246000280	putative deacylase active site [active]
297246000281	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
297246000282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246000283	non-specific DNA binding site [nucleotide binding]; other site
297246000284	salt bridge; other site
297246000285	sequence-specific DNA binding site [nucleotide binding]; other site
297246000286	Cupin domain; Region: Cupin_2; cl09118
297246000287	Phosphotransferase enzyme family; Region: APH; pfam01636
297246000288	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000289	active site
297246000290	ATP binding site [chemical binding]; other site
297246000291	substrate binding site [chemical binding]; other site
297246000292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246000293	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000294	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000295	topology modulation protein; Reviewed; Region: PRK08118
297246000296	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000297	RecX family; Region: RecX; cl00936
297246000298	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
297246000299	DNA binding site [nucleotide binding]
297246000300	Int/Topo IB signature motif; other site
297246000301	active site
297246000302	similar to ATP-dependent DNA helicase RecG(C-terminal part);hypothetical protein
297246000303	Similar to N-terminal part of ATP-dependent DNA helicase recG;hypothetical protein
297246000304	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
297246000305	DnaA N-terminal domain; Region: DnaA_N; pfam11638
297246000306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246000307	Walker A motif; other site
297246000308	ATP binding site [chemical binding]; other site
297246000309	Walker B motif; other site
297246000310	arginine finger; other site
297246000311	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
297246000312	DnaA box-binding interface [nucleotide binding]; other site
297246000313	DNA polymerase III subunit beta; Validated; Region: PRK05643
297246000314	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
297246000315	putative DNA binding surface [nucleotide binding]; other site
297246000316	dimer interface [polypeptide binding]; other site
297246000317	beta-clamp/clamp loader binding surface; other site
297246000318	beta-clamp/translesion DNA polymerase binding surface; other site
297246000319	recombination protein F; Reviewed; Region: recF; PRK00064
297246000320	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000321	Walker A/P-loop; other site
297246000322	ATP binding site [chemical binding]; other site
297246000323	Q-loop/lid; other site
297246000324	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000325	ABC transporter signature motif; other site
297246000326	Walker B; other site
297246000327	D-loop; other site
297246000328	H-loop/switch region; other site
297246000329	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
297246000330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246000331	Mg2+ binding site [ion binding]; other site
297246000332	G-X-G motif; other site
297246000333	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
297246000334	anchoring element; other site
297246000335	dimer interface [polypeptide binding]; other site
297246000336	ATP binding site [chemical binding]; other site
297246000337	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
297246000338	active site
297246000339	putative metal-binding site [ion binding]; other site
297246000340	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
297246000341	agmatine deiminase; Region: agmatine_aguA; TIGR03380
297246000342	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
297246000343	arginine decarboxylase; Provisional; Region: PRK05354
297246000344	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
297246000345	dimer interface [polypeptide binding]; other site
297246000346	active site
297246000347	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
297246000348	catalytic residues [active]
297246000349	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
297246000350	N-carbamolyputrescine amidase; Region: PLN02747
297246000351	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
297246000352	putative active site; other site
297246000353	catalytic triad [active]
297246000354	putative dimer interface [polypeptide binding]; other site
297246000355	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
297246000356	Sm1 motif; other site
297246000357	D3 - B interaction site; other site
297246000358	D1 - D2 interaction site; other site
297246000359	Hfq - Hfq interaction site; other site
297246000360	RNA binding pocket [nucleotide binding]; other site
297246000361	Sm2 motif; other site
297246000362	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
297246000363	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
297246000364	HflX GTPase family; Region: HflX; cd01878
297246000365	G1 box; other site
297246000366	GTP/Mg2+ binding site [chemical binding]; other site
297246000367	Switch I region; other site
297246000368	G2 box; other site
297246000369	G3 box; other site
297246000370	Switch II region; other site
297246000371	G4 box; other site
297246000372	G5 box; other site
297246000373	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
297246000374	catalytic residues [active]
297246000375	Pirin-related protein [General function prediction only]; Region: COG1741
297246000376	Cupin domain; Region: Cupin_2; cl09118
297246000377	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
297246000378	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
297246000379	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
297246000380	active site
297246000381	nucleophile elbow; other site
297246000382	Patatin phospholipase; Region: DUF3734; pfam12536
297246000383	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
297246000384	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000385	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000386	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
297246000387	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246000388	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
297246000389	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
297246000390	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
297246000391	active site
297246000392	Zn binding site [ion binding]; other site
297246000393	Protein of unknown function (DUF615); Region: DUF615; cl01147
297246000394	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
297246000395	THUMP domain; Region: THUMP; cl12076
297246000396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246000398	Protein of unknown function (DUF962); Region: DUF962; cl01879
297246000399	Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181
297246000400	amino acid transporter; Region: 2A0306; TIGR00909
297246000401	Spore germination protein; Region: Spore_permease; cl15802
297246000402	Spore germination protein; Region: Spore_permease; cl15802
297246000403	Phosphate transporter family; Region: PHO4; cl00396
297246000404	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
297246000405	diiron binding motif [ion binding]; other site
297246000406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246000407	PAS domain; Region: PAS_9; pfam13426
297246000408	putative active site [active]
297246000409	heme pocket [chemical binding]; other site
297246000410	PAS domain S-box; Region: sensory_box; TIGR00229
297246000411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246000412	putative active site [active]
297246000413	heme pocket [chemical binding]; other site
297246000414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246000415	PAS domain; Region: PAS_9; pfam13426
297246000416	putative active site [active]
297246000417	heme pocket [chemical binding]; other site
297246000418	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246000419	metal binding site [ion binding]; metal-binding site
297246000420	active site
297246000421	I-site; other site
297246000422	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246000423	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
297246000424	active site
297246000425	metal binding site [ion binding]; metal-binding site
297246000426	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
297246000427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246000428	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246000429	substrate binding pocket [chemical binding]; other site
297246000430	membrane-bound complex binding site; other site
297246000431	hinge residues; other site
297246000432	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246000433	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246000434	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246000435	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246000436	GIY-YIG motif/motif A; other site
297246000437	putative active site [active]
297246000438	putative metal binding site [ion binding]; other site
297246000439	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
297246000440	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246000441	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
297246000442	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
297246000443	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
297246000444	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
297246000445	trimer interface [polypeptide binding]; other site
297246000446	active site
297246000447	substrate binding site [chemical binding]; other site
297246000448	CoA binding site [chemical binding]; other site
297246000449	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
297246000450	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246000451	amino acid transporter; Region: 2A0306; TIGR00909
297246000452	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
297246000453	Protein of unknown function (DUF421); Region: DUF421; cl00990
297246000454	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
297246000455	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
297246000456	tetramer interface [polypeptide binding]; other site
297246000457	active site
297246000458	Mg2+/Mn2+ binding site [ion binding]; other site
297246000459	Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981
297246000460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246000461	Helix-turn-helix domains; Region: HTH; cl00088
297246000462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246000463	dimerization interface [polypeptide binding]; other site
297246000464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246000465	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
297246000466	putative active site [active]
297246000467	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
297246000468	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
297246000469	DNA binding residues [nucleotide binding]
297246000470	dimer interface [polypeptide binding]; other site
297246000471	mercury binding site [ion binding]; other site
297246000472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
297246000473	Predicted membrane protein [Function unknown]; Region: COG3428
297246000474	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
297246000475	HipA N-terminal domain; Region: Couple_hipA; cl11853
297246000476	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
297246000477	HipA-like N-terminal domain; Region: HipA_N; pfam07805
297246000478	HipA-like C-terminal domain; Region: HipA_C; pfam07804
297246000479	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246000480	non-specific DNA binding site [nucleotide binding]; other site
297246000481	salt bridge; other site
297246000482	sequence-specific DNA binding site [nucleotide binding]; other site
297246000483	hypothetical protein
297246000484	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246000485	integrase; Provisional; Region: PRK09692
297246000486	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
297246000487	active site
297246000488	Int/Topo IB signature motif; other site
297246000489	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
297246000490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246000491	non-specific DNA binding site [nucleotide binding]; other site
297246000492	salt bridge; other site
297246000493	sequence-specific DNA binding site [nucleotide binding]; other site
297246000494	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
297246000495	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
297246000496	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246000497	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000498	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000499	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246000500	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000501	activation loop (A-loop); other site
297246000502	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000503	Transposase domain (DUF772); Region: DUF772; cl15789
297246000504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246000505	Transposase domain (DUF772); Region: DUF772; cl15789
297246000506	aspartate aminotransferase; Provisional; Region: PRK05764
297246000507	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
297246000508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246000509	homodimer interface [polypeptide binding]; other site
297246000510	catalytic residue [active]
297246000511	excinuclease ABC subunit B; Provisional; Region: PRK05298
297246000512	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246000513	ATP binding site [chemical binding]; other site
297246000514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246000515	nucleotide binding region [chemical binding]; other site
297246000516	ATP-binding site [chemical binding]; other site
297246000517	Ultra-violet resistance protein B; Region: UvrB; pfam12344
297246000518	UvrB/uvrC motif; Region: UVR; pfam02151
297246000519	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246000520	metal binding site [ion binding]; metal-binding site
297246000521	active site
297246000522	I-site; other site
297246000523	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246000524	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
297246000525	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
297246000526	active site
297246000527	FMN binding site [chemical binding]; other site
297246000528	substrate binding site [chemical binding]; other site
297246000529	3Fe-4S cluster binding site [ion binding]; other site
297246000530	Cell division protein ZapA; Region: ZapA; cl01146
297246000531	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
297246000532	proline aminopeptidase P II; Provisional; Region: PRK10879
297246000533	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
297246000534	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
297246000535	active site
297246000536	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000537	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
297246000538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000539	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
297246000540	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246000541	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
297246000542	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
297246000543	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
297246000544	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
297246000545	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246000546	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246000547	substrate binding pocket [chemical binding]; other site
297246000548	membrane-bound complex binding site; other site
297246000549	hinge residues; other site
297246000550	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
297246000551	ribonuclease R; Region: RNase_R; TIGR02063
297246000552	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
297246000553	RNB domain; Region: RNB; pfam00773
297246000554	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
297246000555	RNA binding site [nucleotide binding]; other site
297246000556	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
297246000557	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
297246000558	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
297246000559	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
297246000560	tetramer (dimer of dimers) interface [polypeptide binding]; other site
297246000561	active site
297246000562	dimer interface [polypeptide binding]; other site
297246000563	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246000564	HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244
297246000565	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
297246000566	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246000567	similar to unknown protein, truncated;hypothetical protein
297246000568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246000569	active site
297246000570	phosphorylation site [posttranslational modification]
297246000571	intermolecular recognition site; other site
297246000572	DNA polymerase I; Provisional; Region: PRK05755
297246000573	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
297246000574	active site
297246000575	metal binding site 1 [ion binding]; metal-binding site
297246000576	putative 5' ssDNA interaction site; other site
297246000577	metal binding site 3; metal-binding site
297246000578	metal binding site 2 [ion binding]; metal-binding site
297246000579	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
297246000580	putative DNA binding site [nucleotide binding]; other site
297246000581	putative metal binding site [ion binding]; other site
297246000582	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
297246000583	active site
297246000584	catalytic site [active]
297246000585	substrate binding site [chemical binding]; other site
297246000586	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
297246000587	active site
297246000588	DNA binding site [nucleotide binding]
297246000589	catalytic site [active]
297246000590	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
297246000591	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
297246000592	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
297246000593	trimer interface [polypeptide binding]; other site
297246000594	active site
297246000595	UDP-GlcNAc binding site [chemical binding]; other site
297246000596	lipid binding site [chemical binding]; lipid-binding site
297246000597	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246000598	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
297246000599	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
297246000600	dimer interface [polypeptide binding]; other site
297246000601	active site
297246000602	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000603	Coenzyme A binding pocket [chemical binding]; other site
297246000604	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
297246000605	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000606	Coenzyme A binding pocket [chemical binding]; other site
297246000607	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
297246000608	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
297246000609	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
297246000610	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
297246000611	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
297246000612	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
297246000613	substrate binding pocket [chemical binding]; other site
297246000614	substrate-Mg2+ binding site; other site
297246000615	aspartate-rich region 1; other site
297246000616	aspartate-rich region 2; other site
297246000617	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246000618	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
297246000619	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246000620	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
297246000621	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
297246000622	tetramer interface [polypeptide binding]; other site
297246000623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246000624	catalytic residue [active]
297246000625	YCII-related domain; Region: YCII; cl00999
297246000626	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
297246000627	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
297246000628	tetramer interface [polypeptide binding]; other site
297246000629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246000630	catalytic residue [active]
297246000631	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
297246000632	lipoyl attachment site [posttranslational modification]; other site
297246000633	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
297246000634	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
297246000635	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
297246000636	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246000637	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
297246000638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246000639	dimer interface [polypeptide binding]; other site
297246000640	conserved gate region; other site
297246000641	putative PBP binding loops; other site
297246000642	ABC-ATPase subunit interface; other site
297246000643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
297246000644	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
297246000645	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
297246000646	Walker A/P-loop; other site
297246000647	ATP binding site [chemical binding]; other site
297246000648	Q-loop/lid; other site
297246000649	ABC transporter signature motif; other site
297246000650	Walker B; other site
297246000651	D-loop; other site
297246000652	H-loop/switch region; other site
297246000653	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
297246000654	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
297246000655	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
297246000656	catalytic residues [active]
297246000657	hinge region; other site
297246000658	alpha helical domain; other site
297246000659	Cytochrome c; Region: Cytochrom_C; cl11414
297246000660	Cytochrome c; Region: Cytochrom_C; cl11414
297246000661	Predicted GTPase [General function prediction only]; Region: COG0218
297246000662	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
297246000663	G1 box; other site
297246000664	GTP/Mg2+ binding site [chemical binding]; other site
297246000665	Switch I region; other site
297246000666	G2 box; other site
297246000667	G3 box; other site
297246000668	Switch II region; other site
297246000669	G4 box; other site
297246000670	G5 box; other site
297246000671	acetyl-CoA synthetase; Provisional; Region: PRK00174
297246000672	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
297246000673	AMP-binding enzyme; Region: AMP-binding; cl15778
297246000674	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246000675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000676	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
297246000677	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
297246000678	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246000679	tetrameric interface [polypeptide binding]; other site
297246000680	NAD binding site [chemical binding]; other site
297246000681	catalytic residues [active]
297246000682	Dodecin; Region: Dodecin; cl01328
297246000683	dihydrodipicolinate reductase; Provisional; Region: PRK00048
297246000684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000685	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
297246000686	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
297246000687	putative RNA binding sites [nucleotide binding]; other site
297246000688	MltA specific insert domain; Region: MltA; cl08398
297246000689	pyruvate kinase; Provisional; Region: PRK05826
297246000690	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
297246000691	domain interfaces; other site
297246000692	active site
297246000693	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
297246000694	Phosphoglycerate kinase; Region: PGK; pfam00162
297246000695	substrate binding site [chemical binding]; other site
297246000696	hinge regions; other site
297246000697	ADP binding site [chemical binding]; other site
297246000698	catalytic site [active]
297246000699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000700	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
297246000701	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
297246000702	transketolase; Reviewed; Region: PRK12753
297246000703	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
297246000704	TPP-binding site [chemical binding]; other site
297246000705	dimer interface [polypeptide binding]; other site
297246000706	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
297246000707	PYR/PP interface [polypeptide binding]; other site
297246000708	dimer interface [polypeptide binding]; other site
297246000709	TPP binding site [chemical binding]; other site
297246000710	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
297246000711	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
297246000712	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
297246000713	active site
297246000714	Zn binding site [ion binding]; other site
297246000715	hypothetical protein
297246000716	hypothetical protein
297246000717	CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704
297246000718	CRISPR-associated protein Cas9/Csx12, subtype II-B/NMENI; Region: cas_csx12; TIGR03031
297246000719	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
297246000720	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
297246000721	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
297246000722	similar to unknown proteins;hypothetical protein
297246000723	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
297246000724	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
297246000725	Catalytic site [active]
297246000726	Global regulator protein family; Region: CsrA; cl00670
297246000727	TrbC/VIRB2 family; Region: TrbC; cl01583
297246000728	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
297246000729	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
297246000730	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
297246000731	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
297246000732	Type IV secretion system proteins; Region: T4SS; pfam07996
297246000733	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
297246000734	VirB8 protein; Region: VirB8; cl01500
297246000735	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
297246000736	VirB7 interaction site; other site
297246000737	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
297246000738	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
297246000739	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
297246000740	Walker A motif; other site
297246000741	hexamer interface [polypeptide binding]; other site
297246000742	ATP binding site [chemical binding]; other site
297246000743	Walker B motif; other site
297246000744	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
297246000745	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000746	Walker A motif; other site
297246000747	ATP binding site [chemical binding]; other site
297246000748	Walker B motif; other site
297246000749	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000750	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
297246000751	MobA/MobL family; Region: MobA_MobL; pfam03389
297246000752	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000753	Family description; Region: UvrD_C_2; cl15862
297246000754	Conjugal transfer protein TraD; Region: TraD; cl05753
297246000755	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246000756	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
297246000757	nucleoside/Zn binding site; other site
297246000758	dimer interface [polypeptide binding]; other site
297246000759	catalytic motif [active]
297246000760	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
297246000761	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
297246000762	Predicted transcriptional regulator [Transcription]; Region: COG2932
297246000763	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246000764	non-specific DNA binding site [nucleotide binding]; other site
297246000765	sequence-specific DNA binding site [nucleotide binding]; other site
297246000766	salt bridge; other site
297246000767	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
297246000768	Catalytic site [active]
297246000769	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
297246000770	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
297246000771	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
297246000772	Int/Topo IB signature motif; other site
297246000773	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
297246000774	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
297246000775	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000776	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
297246000777	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000778	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
297246000779	Restriction endonuclease [Defense mechanisms]; Region: COG3587
297246000780	Helix-turn-helix domains; Region: HTH; cl00088
297246000781	similar to transposase;hypothetical protein
297246000782	Transposase IS200 like; Region: Y1_Tnp; cl00848
297246000783	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246000784	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246000785	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246000786	Transposase IS200 like; Region: Y1_Tnp; cl00848
297246000787	Similar to C-terminal part of phage integrase;hypothetical protein
297246000788	Transposase IS200 like; Region: Y1_Tnp; cl00848
297246000789	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
297246000790	active site
297246000791	Similar to transposase (ISL3 family);hypothetical protein
297246000792	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
297246000793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246000794	Coenzyme A binding pocket [chemical binding]; other site
297246000795	PAS domain; Region: PAS_9; pfam13426
297246000796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246000797	putative active site [active]
297246000798	heme pocket [chemical binding]; other site
297246000799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246000800	metal binding site [ion binding]; metal-binding site
297246000801	active site
297246000802	I-site; other site
297246000803	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246000804	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
297246000805	active site
297246000806	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
297246000807	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
297246000808	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246000809	Acyl transferase domain; Region: Acyl_transf_1; cl08282
297246000810	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
297246000811	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
297246000812	Protein of unknown function (DUF808); Region: DUF808; cl01002
297246000813	RF-1 domain; Region: RF-1; cl02875
297246000814	Protein of unknown function (DUF330); Region: DUF330; cl01135
297246000815	paraquat-inducible protein B; Provisional; Region: PRK10807
297246000816	mce related protein; Region: MCE; pfam02470
297246000817	Permease; Region: Permease; cl00510
297246000818	F-box domain; Region: F-box; cl02535
297246000819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246000820	Helix-turn-helix domains; Region: HTH; cl00088
297246000821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
297246000822	dimerization interface [polypeptide binding]; other site
297246000823	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
297246000824	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
297246000825	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
297246000826	substrate binding pocket [chemical binding]; other site
297246000827	active site
297246000828	iron coordination sites [ion binding]; other site
297246000829	hypothetical protein; Provisional; Region: PRK07190
297246000830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000832	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
297246000833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246000834	putative substrate translocation pore; other site
297246000835	hypothetical protein; Provisional; Region: PRK07206
297246000836	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246000837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246000838	S-adenosylmethionine binding site [chemical binding]; other site
297246000839	Peptidase family M48; Region: Peptidase_M48; cl12018
297246000840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000841	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
297246000842	hypothetical protein; Provisional; Region: PRK09133
297246000843	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
297246000844	putative metal binding site [ion binding]; other site
297246000845	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
297246000846	CoA-transferase family III; Region: CoA_transf_3; pfam02515
297246000847	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
297246000848	dimer interface [polypeptide binding]; other site
297246000849	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
297246000850	active site
297246000851	heme binding site [chemical binding]; other site
297246000852	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
297246000853	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
297246000854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
297246000855	Chitin binding domain; Region: Chitin_bind_3; cl03871
297246000856	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
297246000857	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
297246000858	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
297246000859	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
297246000860	Phospholipid methyltransferase; Region: PEMT; cl00763
297246000861	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
297246000862	DAK2 domain; Region: Dak2; cl03685
297246000863	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
297246000864	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
297246000865	classical (c) SDRs; Region: SDR_c; cd05233
297246000866	NAD(P) binding site [chemical binding]; other site
297246000867	active site
297246000868	similar to unknown protein (N-terminal part);hypothetical protein
297246000869	similar to unknown protein (C-terminal part);hypothetical protein
297246000870	Predicted membrane protein (DUF2177); Region: DUF2177; cl02014
297246000871	Catalytic domain of Protein Kinases; Region: PKc; cd00180
297246000872	active site
297246000873	ATP binding site [chemical binding]; other site
297246000874	substrate binding site [chemical binding]; other site
297246000875	activation loop (A-loop); other site
297246000876	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
297246000877	TspO/MBR family; Region: TspO_MBR; cl01379
297246000878	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
297246000879	DNA photolyase; Region: DNA_photolyase; pfam00875
297246000880	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
297246000881	LrgB-like family; Region: LrgB; cl00596
297246000882	LrgA family; Region: LrgA; cl00608
297246000883	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246000884	Helix-turn-helix domains; Region: HTH; cl00088
297246000885	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
297246000886	putative dimerization interface [polypeptide binding]; other site
297246000887	Domain of unknown function (DUF329); Region: DUF329; cl01144
297246000888	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
297246000889	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246000890	AIR carboxylase; Region: AIRC; cl00310
297246000891	Double zinc ribbon; Region: DZR; pfam12773
297246000892	Nitrogen regulatory protein P-II; Region: P-II; cl00412
297246000893	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
297246000894	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
297246000895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
297246000896	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246000897	Helix-turn-helix domains; Region: HTH; cl00088
297246000898	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246000899	dimerization interface [polypeptide binding]; other site
297246000900	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246000901	ATP binding site [chemical binding]; other site
297246000902	Walker A/P-loop; other site
297246000903	Q-loop/lid; other site
297246000904	ABC transporter signature motif; other site
297246000905	Walker B; other site
297246000906	D-loop; other site
297246000907	H-loop/switch region; other site
297246000908	HlyD family secretion protein; Region: HlyD; pfam00529
297246000909	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000910	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246000911	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246000912	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
297246000913	Spore germination protein; Region: Spore_permease; cl15802
297246000914	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
297246000915	heme binding pocket [chemical binding]; other site
297246000916	heme ligand [chemical binding]; other site
297246000917	hypothetical gene;hypothetical protein
297246000918	similar to unknown protein;hypothetical protein
297246000919	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
297246000920	classical (c) SDRs; Region: SDR_c; cd05233
297246000921	NAD(P) binding site [chemical binding]; other site
297246000922	active site
297246000923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246000924	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246000925	putative substrate translocation pore; other site
297246000926	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
297246000927	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
297246000928	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
297246000929	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
297246000930	D-pathway; other site
297246000931	Putative ubiquinol binding site [chemical binding]; other site
297246000932	Low-spin heme (heme b) binding site [chemical binding]; other site
297246000933	Putative water exit pathway; other site
297246000934	Binuclear center (heme o3/CuB) [ion binding]; other site
297246000935	K-pathway; other site
297246000936	Putative proton exit pathway; other site
297246000937	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
297246000938	Subunit I/III interface [polypeptide binding]; other site
297246000939	Subunit III/IV interface [polypeptide binding]; other site
297246000940	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
297246000941	CHASE3 domain; Region: CHASE3; cl05000
297246000942	PAS domain; Region: PAS_9; pfam13426
297246000943	GAF domain; Region: GAF; cl15785
297246000944	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246000945	metal binding site [ion binding]; metal-binding site
297246000946	active site
297246000947	I-site; other site
297246000948	CHASE3 domain; Region: CHASE3; cl05000
297246000949	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
297246000950	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246000951	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246000952	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
297246000953	metal binding site 2 [ion binding]; metal-binding site
297246000954	putative DNA binding helix; other site
297246000955	metal binding site 1 [ion binding]; metal-binding site
297246000956	dimer interface [polypeptide binding]; other site
297246000957	structural Zn2+ binding site [ion binding]; other site
297246000958	Dot/Icm substrate protein; Region: SidE; pfam12252
297246000959	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
297246000960	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246000961	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246000962	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
297246000963	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246000964	tetramerization interface [polypeptide binding]; other site
297246000965	NAD(P) binding site [chemical binding]; other site
297246000966	catalytic residues [active]
297246000967	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
297246000968	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
297246000969	inhibitor-cofactor binding pocket; inhibition site
297246000970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246000971	catalytic residue [active]
297246000972	Glutaminase; Region: Glutaminase; cl00907
297246000973	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
297246000974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000976	NAD(P) binding site [chemical binding]; other site
297246000977	active site
297246000978	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000979	mercuric reductase; Validated; Region: PRK06370
297246000980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246000981	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
297246000982	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
297246000983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246000984	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
297246000985	ArsC family; Region: ArsC; pfam03960
297246000986	catalytic residues [active]
297246000987	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
297246000988	Di-iron ligands [ion binding]; other site
297246000989	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246000990	helicase 45; Provisional; Region: PTZ00424
297246000991	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
297246000992	ATP binding site [chemical binding]; other site
297246000993	Mg++ binding site [ion binding]; other site
297246000994	motif III; other site
297246000995	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246000996	nucleotide binding region [chemical binding]; other site
297246000997	ATP-binding site [chemical binding]; other site
297246000998	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
297246000999	RNA/DNA binding site [nucleotide binding]; other site
297246001000	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
297246001001	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
297246001002	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246001003	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
297246001004	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
297246001005	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001006	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001007	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246001008	GIY-YIG motif/motif A; other site
297246001009	putative active site [active]
297246001010	putative metal binding site [ion binding]; other site
297246001011	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
297246001012	Fe-S cluster binding site [ion binding]; other site
297246001013	active site
297246001014	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
297246001015	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
297246001016	amidase catalytic site [active]
297246001017	Zn binding residues [ion binding]; other site
297246001018	substrate binding site [chemical binding]; other site
297246001019	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246001020	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246001021	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246001022	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
297246001023	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
297246001024	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246001025	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
297246001026	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
297246001027	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
297246001028	active site
297246001029	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
297246001030	catalytic triad [active]
297246001031	metal binding site [ion binding]; metal-binding site
297246001032	conserved cis-peptide bond; other site
297246001033	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
297246001034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246001035	metal binding site [ion binding]; metal-binding site
297246001036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001037	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
297246001038	putative substrate translocation pore; other site
297246001039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246001040	Helix-turn-helix domains; Region: HTH; cl00088
297246001041	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
297246001042	putative effector binding pocket; other site
297246001043	dimerization interface [polypeptide binding]; other site
297246001044	Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485
297246001045	Ras interaction site [polypeptide binding]; other site
297246001046	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246001047	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
297246001048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246001049	active site
297246001050	phosphorylation site [posttranslational modification]
297246001051	intermolecular recognition site; other site
297246001052	dimerization interface [polypeptide binding]; other site
297246001053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246001054	PAS fold; Region: PAS_7; pfam12860
297246001055	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246001056	metal binding site [ion binding]; metal-binding site
297246001057	active site
297246001058	I-site; other site
297246001059	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246001060	putative active site [active]
297246001061	heme pocket [chemical binding]; other site
297246001062	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
297246001063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246001064	ATP binding site [chemical binding]; other site
297246001065	Mg2+ binding site [ion binding]; other site
297246001066	G-X-G motif; other site
297246001067	FIST N domain; Region: FIST; cl10701
297246001068	Uncharacterized conserved protein [Function unknown]; Region: COG3287
297246001069	FIST C domain; Region: FIST_C; pfam10442
297246001070	Helix-turn-helix domains; Region: HTH; cl00088
297246001071	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
297246001072	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
297246001073	dimerization interface [polypeptide binding]; other site
297246001074	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246001075	amino acid transporter; Region: 2A0306; TIGR00909
297246001076	Spore germination protein; Region: Spore_permease; cl15802
297246001077	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
297246001078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246001079	S-adenosylmethionine binding site [chemical binding]; other site
297246001080	formate dehydrogenase; Provisional; Region: PRK07574
297246001081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001082	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
297246001083	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
297246001084	putative NAD(P) binding site [chemical binding]; other site
297246001085	homodimer interface [polypeptide binding]; other site
297246001086	homotetramer interface [polypeptide binding]; other site
297246001087	active site
297246001088	elongation factor P; Validated; Region: PRK00529
297246001089	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
297246001090	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
297246001091	RNA binding site [nucleotide binding]; other site
297246001092	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
297246001093	RNA binding site [nucleotide binding]; other site
297246001094	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
297246001095	Radical SAM superfamily; Region: Radical_SAM; pfam04055
297246001096	polyphosphate kinase; Provisional; Region: PRK05443
297246001097	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
297246001098	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
297246001099	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
297246001100	putative active site [active]
297246001101	catalytic site [active]
297246001102	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
297246001103	putative domain interface [polypeptide binding]; other site
297246001104	putative active site [active]
297246001105	catalytic site [active]
297246001106	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
297246001107	nucleophile elbow; other site
297246001108	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
297246001109	Chromate transporter; Region: Chromate_transp; pfam02417
297246001110	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
297246001111	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
297246001112	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
297246001113	active site
297246001114	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
297246001115	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
297246001116	Substrate binding site; other site
297246001117	metal-binding site
297246001118	Phosphotransferase enzyme family; Region: APH; pfam01636
297246001119	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246001120	active site
297246001121	ATP binding site [chemical binding]; other site
297246001122	substrate binding site [chemical binding]; other site
297246001123	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
297246001124	OstA-like protein; Region: OstA; cl00844
297246001125	Organic solvent tolerance protein; Region: OstA_C; pfam04453
297246001126	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
297246001127	SurA N-terminal domain; Region: SurA_N_3; cl07813
297246001128	PPIC-type PPIASE domain; Region: Rotamase; cl08278
297246001129	PPIC-type PPIASE domain; Region: Rotamase; cl08278
297246001130	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
297246001131	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
297246001132	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
297246001133	folate binding site [chemical binding]; other site
297246001134	NADP+ binding site [chemical binding]; other site
297246001135	Repeats found in Drosophila proteins; Region: DM9; smart00696
297246001136	Protein of unknown function (DUF3421); Region: DUF3421; pfam11901
297246001137	Repeats found in Drosophila proteins; Region: DM9; smart00696
297246001138	elongation factor Tu; Reviewed; Region: PRK00049
297246001139	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
297246001140	G1 box; other site
297246001141	GEF interaction site [polypeptide binding]; other site
297246001142	GTP/Mg2+ binding site [chemical binding]; other site
297246001143	Switch I region; other site
297246001144	G2 box; other site
297246001145	G3 box; other site
297246001146	Switch II region; other site
297246001147	G4 box; other site
297246001148	G5 box; other site
297246001149	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
297246001150	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
297246001151	Antibiotic Binding Site [chemical binding]; other site
297246001152	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
297246001153	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
297246001154	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
297246001155	putative homodimer interface [polypeptide binding]; other site
297246001156	KOW motif; Region: KOW; cl00354
297246001157	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
297246001158	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
297246001159	23S rRNA interface [nucleotide binding]; other site
297246001160	L7/L12 interface [polypeptide binding]; other site
297246001161	putative thiostrepton binding site; other site
297246001162	L25 interface [polypeptide binding]; other site
297246001163	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
297246001164	mRNA/rRNA interface [nucleotide binding]; other site
297246001165	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
297246001166	23S rRNA interface [nucleotide binding]; other site
297246001167	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
297246001168	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
297246001169	peripheral dimer interface [polypeptide binding]; other site
297246001170	core dimer interface [polypeptide binding]; other site
297246001171	L10 interface [polypeptide binding]; other site
297246001172	L11 interface [polypeptide binding]; other site
297246001173	putative EF-Tu interaction site [polypeptide binding]; other site
297246001174	putative EF-G interaction site [polypeptide binding]; other site
297246001175	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
297246001176	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
297246001177	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
297246001178	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
297246001179	RPB11 interaction site [polypeptide binding]; other site
297246001180	RPB12 interaction site [polypeptide binding]; other site
297246001181	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
297246001182	RPB3 interaction site [polypeptide binding]; other site
297246001183	RPB1 interaction site [polypeptide binding]; other site
297246001184	RPB11 interaction site [polypeptide binding]; other site
297246001185	RPB10 interaction site [polypeptide binding]; other site
297246001186	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
297246001187	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
297246001188	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
297246001189	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
297246001190	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
297246001191	DNA-directed RNA polymerase subunit A''; Validated; Region: PRK04309
297246001192	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
297246001193	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
297246001194	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
297246001195	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
297246001196	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
297246001197	DNA binding site [nucleotide binding]
297246001198	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
297246001199	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
297246001200	S17 interaction site [polypeptide binding]; other site
297246001201	S8 interaction site; other site
297246001202	16S rRNA interaction site [nucleotide binding]; other site
297246001203	streptomycin interaction site [chemical binding]; other site
297246001204	23S rRNA interaction site [nucleotide binding]; other site
297246001205	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
297246001206	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
297246001207	elongation factor G; Reviewed; Region: PRK00007
297246001208	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
297246001209	G1 box; other site
297246001210	putative GEF interaction site [polypeptide binding]; other site
297246001211	GTP/Mg2+ binding site [chemical binding]; other site
297246001212	Switch I region; other site
297246001213	G2 box; other site
297246001214	G3 box; other site
297246001215	Switch II region; other site
297246001216	G4 box; other site
297246001217	G5 box; other site
297246001218	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
297246001219	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
297246001220	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
297246001221	elongation factor Tu; Reviewed; Region: PRK00049
297246001222	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
297246001223	G1 box; other site
297246001224	GEF interaction site [polypeptide binding]; other site
297246001225	GTP/Mg2+ binding site [chemical binding]; other site
297246001226	Switch I region; other site
297246001227	G2 box; other site
297246001228	G3 box; other site
297246001229	Switch II region; other site
297246001230	G4 box; other site
297246001231	G5 box; other site
297246001232	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
297246001233	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
297246001234	Antibiotic Binding Site [chemical binding]; other site
297246001235	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
297246001236	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
297246001237	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
297246001238	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
297246001239	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
297246001240	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
297246001241	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
297246001242	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
297246001243	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
297246001244	putative translocon binding site; other site
297246001245	protein-rRNA interface [nucleotide binding]; other site
297246001246	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
297246001247	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
297246001248	G-X-X-G motif; other site
297246001249	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
297246001250	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
297246001251	23S rRNA interface [nucleotide binding]; other site
297246001252	5S rRNA interface [nucleotide binding]; other site
297246001253	putative antibiotic binding site [chemical binding]; other site
297246001254	L25 interface [polypeptide binding]; other site
297246001255	L27 interface [polypeptide binding]; other site
297246001256	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
297246001257	putative translocon interaction site; other site
297246001258	23S rRNA interface [nucleotide binding]; other site
297246001259	signal recognition particle (SRP54) interaction site; other site
297246001260	L23 interface [polypeptide binding]; other site
297246001261	trigger factor interaction site; other site
297246001262	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
297246001263	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
297246001264	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
297246001265	KOW motif; Region: KOW; cl00354
297246001266	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
297246001267	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
297246001268	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
297246001269	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
297246001270	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
297246001271	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
297246001272	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
297246001273	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
297246001274	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
297246001275	23S rRNA interface [nucleotide binding]; other site
297246001276	L21e interface [polypeptide binding]; other site
297246001277	5S rRNA interface [nucleotide binding]; other site
297246001278	L27 interface [polypeptide binding]; other site
297246001279	L5 interface [polypeptide binding]; other site
297246001280	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
297246001281	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
297246001282	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
297246001283	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
297246001284	23S rRNA binding site [nucleotide binding]; other site
297246001285	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
297246001286	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
297246001287	SecY translocase; Region: SecY; pfam00344
297246001288	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
297246001289	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
297246001290	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
297246001291	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
297246001292	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
297246001293	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
297246001294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
297246001295	RNA binding surface [nucleotide binding]; other site
297246001296	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
297246001297	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
297246001298	alphaNTD homodimer interface [polypeptide binding]; other site
297246001299	alphaNTD - beta interaction site [polypeptide binding]; other site
297246001300	alphaNTD - beta' interaction site [polypeptide binding]; other site
297246001301	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
297246001302	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
297246001303	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
297246001304	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
297246001305	dimer interface [polypeptide binding]; other site
297246001306	ssDNA binding site [nucleotide binding]; other site
297246001307	tetramer (dimer of dimers) interface [polypeptide binding]; other site
297246001308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246001310	putative substrate translocation pore; other site
297246001311	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
297246001312	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
297246001313	putative NAD(P) binding site [chemical binding]; other site
297246001314	active site
297246001315	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246001316	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
297246001317	active site 2 [active]
297246001318	active site 1 [active]
297246001319	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
297246001320	active site 2 [active]
297246001321	dimer interface [polypeptide binding]; other site
297246001322	active site 1 [active]
297246001323	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
297246001324	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
297246001325	dimer interface [polypeptide binding]; other site
297246001326	active site
297246001327	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
297246001328	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
297246001329	dimer interface [polypeptide binding]; other site
297246001330	active site
297246001331	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
297246001332	putative acyl-acceptor binding pocket; other site
297246001333	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
297246001334	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
297246001335	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
297246001336	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
297246001337	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
297246001338	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246001339	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
297246001340	putative coenzyme Q binding site [chemical binding]; other site
297246001341	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
297246001342	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
297246001343	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
297246001344	metal binding site 2 [ion binding]; metal-binding site
297246001345	putative DNA binding helix; other site
297246001346	metal binding site 1 [ion binding]; metal-binding site
297246001347	dimer interface [polypeptide binding]; other site
297246001348	structural Zn2+ binding site [ion binding]; other site
297246001349	similar to choline dehydrogenase (N-terminal part);hypothetical protein
297246001350	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246001351	metal binding site [ion binding]; metal-binding site
297246001352	active site
297246001353	I-site; other site
297246001354	N-formylglutamate amidohydrolase; Region: FGase; cl01522
297246001355	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
297246001356	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
297246001357	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
297246001358	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246001359	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
297246001360	CoenzymeA binding site [chemical binding]; other site
297246001361	subunit interaction site [polypeptide binding]; other site
297246001362	PHB binding site; other site
297246001363	BON domain; Region: BON; cl02771
297246001364	BON domain; Region: BON; cl02771
297246001365	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246001366	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
297246001367	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
297246001368	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
297246001369	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
297246001370	LemA family; Region: LemA; cl00742
297246001371	Peptidase family M48; Region: Peptidase_M48; cl12018
297246001372	ABC-2 type transporter; Region: ABC2_membrane; cl11417
297246001373	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
297246001374	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246001375	Walker A/P-loop; other site
297246001376	ATP binding site [chemical binding]; other site
297246001377	Q-loop/lid; other site
297246001378	ABC transporter signature motif; other site
297246001379	Walker B; other site
297246001380	D-loop; other site
297246001381	H-loop/switch region; other site
297246001382	hypothetical protein
297246001383	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
297246001384	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246001385	Protein of unknown function DUF45; Region: DUF45; cl00636
297246001386	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
297246001387	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
297246001388	DNA binding site [nucleotide binding]
297246001389	active site
297246001390	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
297246001391	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
297246001392	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
297246001393	RimM N-terminal domain; Region: RimM; pfam01782
297246001394	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
297246001395	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
297246001396	signal recognition particle protein; Provisional; Region: PRK10867
297246001397	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
297246001398	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
297246001399	P loop; other site
297246001400	GTP binding site [chemical binding]; other site
297246001401	Signal peptide binding domain; Region: SRP_SPB; pfam02978
297246001402	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246001403	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246001404	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246001405	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
297246001406	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
297246001407	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
297246001408	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
297246001409	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
297246001410	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
297246001411	UbiA prenyltransferase family; Region: UbiA; cl00337
297246001412	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
297246001413	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
297246001414	Cu(I) binding site [ion binding]; other site
297246001415	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
297246001416	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246001417	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
297246001418	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
297246001419	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
297246001420	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
297246001421	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
297246001422	putative active site [active]
297246001423	Dehydratase family; Region: ILVD_EDD; cl00340
297246001424	6-phosphogluconate dehydratase; Region: edd; TIGR01196
297246001425	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
297246001426	glucokinase, proteobacterial type; Region: glk; TIGR00749
297246001427	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
297246001428	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
297246001429	active site
297246001430	intersubunit interface [polypeptide binding]; other site
297246001431	catalytic residue [active]
297246001432	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
297246001433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001434	putative substrate translocation pore; other site
297246001435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001436	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
297246001437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
297246001438	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
297246001439	ferrochelatase; Reviewed; Region: hemH; PRK00035
297246001440	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
297246001441	C-terminal domain interface [polypeptide binding]; other site
297246001442	active site
297246001443	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
297246001444	active site
297246001445	N-terminal domain interface [polypeptide binding]; other site
297246001446	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246001447	DNA-binding site [nucleotide binding]; DNA binding site
297246001448	RNA-binding motif; other site
297246001449	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
297246001450	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
297246001451	active site
297246001452	metal binding site [ion binding]; metal-binding site
297246001453	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246001454	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
297246001455	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001456	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001457	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
297246001458	Helix-turn-helix domains; Region: HTH; cl00088
297246001459	Uncharacterized conserved protein [Function unknown]; Region: COG4278
297246001460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001461	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246001462	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246001463	Protein of unknown function (DUF3773); Region: DUF3773; pfam12608
297246001464	Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; cl09711
297246001465	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
297246001466	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
297246001467	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246001468	ligand binding site [chemical binding]; other site
297246001469	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246001470	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
297246001471	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
297246001472	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
297246001473	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
297246001474	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
297246001475	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
297246001476	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
297246001477	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
297246001478	AAA-like domain; Region: AAA_10; pfam12846
297246001479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001480	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246001481	putative substrate translocation pore; other site
297246001482	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
297246001483	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
297246001484	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
297246001485	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
297246001486	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
297246001487	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
297246001488	purine monophosphate binding site [chemical binding]; other site
297246001489	dimer interface [polypeptide binding]; other site
297246001490	putative catalytic residues [active]
297246001491	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
297246001492	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
297246001493	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
297246001494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001495	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
297246001496	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
297246001497	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246001498	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
297246001499	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
297246001500	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
297246001501	carboxyltransferase (CT) interaction site; other site
297246001502	biotinylation site [posttranslational modification]; other site
297246001503	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
297246001504	trimer interface [polypeptide binding]; other site
297246001505	active site
297246001506	dimer interface [polypeptide binding]; other site
297246001507	pyruvate carboxylase subunit B; Provisional; Region: PRK14042
297246001508	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
297246001509	active site
297246001510	catalytic residues [active]
297246001511	metal binding site [ion binding]; metal-binding site
297246001512	homodimer binding site [polypeptide binding]; other site
297246001513	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
297246001514	carboxyltransferase (CT) interaction site; other site
297246001515	biotinylation site [posttranslational modification]; other site
297246001516	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
297246001517	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
297246001518	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
297246001519	active site
297246001520	Zn binding site [ion binding]; other site
297246001521	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246001522	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246001523	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
297246001524	putative catalytic site [active]
297246001525	putative metal binding site [ion binding]; other site
297246001526	putative phosphate binding site [ion binding]; other site
297246001527	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
297246001528	active site
297246001529	intersubunit interface [polypeptide binding]; other site
297246001530	catalytic residue [active]
297246001531	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
297246001532	ferredoxin-NADP reductase; Provisional; Region: PRK10926
297246001533	FAD binding pocket [chemical binding]; other site
297246001534	FAD binding motif [chemical binding]; other site
297246001535	phosphate binding motif [ion binding]; other site
297246001536	beta-alpha-beta structure motif; other site
297246001537	NAD binding pocket [chemical binding]; other site
297246001538	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
297246001539	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
297246001540	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
297246001541	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
297246001542	dimerization domain swap beta strand [polypeptide binding]; other site
297246001543	regulatory protein interface [polypeptide binding]; other site
297246001544	active site
297246001545	regulatory phosphorylation site [posttranslational modification]; other site
297246001546	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
297246001547	30S subunit binding site; other site
297246001548	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
297246001549	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
297246001550	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
297246001551	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
297246001552	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
297246001553	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
297246001554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246001555	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
297246001556	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
297246001557	oligomer interface [polypeptide binding]; other site
297246001558	active site
297246001559	metal binding site [ion binding]; metal-binding site
297246001560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001561	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246001562	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246001563	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
297246001564	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
297246001565	HflK protein; Region: hflK; TIGR01933
297246001566	FtsH protease regulator HflC; Provisional; Region: PRK11029
297246001567	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
297246001568	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
297246001569	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
297246001570	GDP-binding site [chemical binding]; other site
297246001571	ACT binding site; other site
297246001572	IMP binding site; other site
297246001573	Cysteine dioxygenase type I; Region: CDO_I; cl15835
297246001574	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
297246001575	Arginine repressor [Transcription]; Region: ArgR; COG1438
297246001576	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
297246001577	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246001578	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246001579	substrate binding pocket [chemical binding]; other site
297246001580	membrane-bound complex binding site; other site
297246001581	hinge residues; other site
297246001582	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
297246001583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246001584	dimer interface [polypeptide binding]; other site
297246001585	conserved gate region; other site
297246001586	putative PBP binding loops; other site
297246001587	ABC-ATPase subunit interface; other site
297246001588	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
297246001589	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246001590	Walker A/P-loop; other site
297246001591	ATP binding site [chemical binding]; other site
297246001592	Q-loop/lid; other site
297246001593	ABC transporter signature motif; other site
297246001594	Walker B; other site
297246001595	D-loop; other site
297246001596	H-loop/switch region; other site
297246001597	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
297246001598	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
297246001599	ANP binding site [chemical binding]; other site
297246001600	Substrate Binding Site II [chemical binding]; other site
297246001601	Substrate Binding Site I [chemical binding]; other site
297246001602	Lyase; Region: Lyase_1; pfam00206
297246001603	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
297246001604	active sites [active]
297246001605	tetramer interface [polypeptide binding]; other site
297246001606	ornithine carbamoyltransferase; Provisional; Region: PRK00779
297246001607	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
297246001608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001609	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
297246001610	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246001611	active site
297246001612	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
297246001613	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
297246001614	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
297246001615	C-terminal peptidase (prc); Region: prc; TIGR00225
297246001616	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
297246001617	protein binding site [polypeptide binding]; other site
297246001618	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
297246001619	Catalytic dyad [active]
297246001620	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
297246001621	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
297246001622	Sulfatase; Region: Sulfatase; cl10460
297246001623	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
297246001624	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
297246001625	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
297246001626	catalytic residue [active]
297246001627	putative FPP diphosphate  binding site; other site
297246001628	putative FPP binding hydrophobic cleft; other site
297246001629	dimer interface [polypeptide binding]; other site
297246001630	putative IPP diphosphate binding site; other site
297246001631	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
297246001632	zinc metallopeptidase RseP; Provisional; Region: PRK10779
297246001633	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
297246001634	active site
297246001635	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
297246001636	protein binding site [polypeptide binding]; other site
297246001637	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
297246001638	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
297246001639	putative substrate binding region [chemical binding]; other site
297246001640	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
297246001641	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
297246001642	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
297246001643	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
297246001644	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
297246001645	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
297246001646	Surface antigen; Region: Bac_surface_Ag; cl03097
297246001647	periplasmic chaperone; Provisional; Region: PRK10780
297246001648	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
297246001649	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
297246001650	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
297246001651	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
297246001652	trimer interface [polypeptide binding]; other site
297246001653	active site
297246001654	UDP-GlcNAc binding site [chemical binding]; other site
297246001655	lipid binding site [chemical binding]; lipid-binding site
297246001656	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
297246001657	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
297246001658	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
297246001659	active site
297246001660	CrcB-like protein; Region: CRCB; cl09114
297246001661	seryl-tRNA synthetase; Provisional; Region: PRK05431
297246001662	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
297246001663	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
297246001664	dimer interface [polypeptide binding]; other site
297246001665	active site
297246001666	motif 1; other site
297246001667	motif 2; other site
297246001668	motif 3; other site
297246001669	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
297246001670	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246001671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001672	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
297246001673	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
297246001674	active site
297246001675	catalytic tetrad [active]
297246001676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001677	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246001678	AAA domain; Region: AAA_18; pfam13238
297246001679	active site
297246001680	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
297246001681	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246001682	Coenzyme A binding pocket [chemical binding]; other site
297246001683	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
297246001684	Phosphotransferase enzyme family; Region: APH; pfam01636
297246001685	active site
297246001686	substrate binding site [chemical binding]; other site
297246001687	ATP binding site [chemical binding]; other site
297246001688	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
297246001689	dimer interface [polypeptide binding]; other site
297246001690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246001691	Mn binding site [ion binding]; other site
297246001692	K binding site; other site
297246001693	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
297246001694	RDD family; Region: RDD; cl00746
297246001695	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
297246001696	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
297246001697	Iron-sulfur protein interface; other site
297246001698	proximal quinone binding site [chemical binding]; other site
297246001699	SdhD (CybS) interface [polypeptide binding]; other site
297246001700	proximal heme binding site [chemical binding]; other site
297246001701	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
297246001702	SdhC subunit interface [polypeptide binding]; other site
297246001703	proximal heme binding site [chemical binding]; other site
297246001704	cardiolipin binding site; other site
297246001705	Iron-sulfur protein interface; other site
297246001706	proximal quinone binding site [chemical binding]; other site
297246001707	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
297246001708	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001709	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
297246001710	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
297246001711	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
297246001712	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
297246001713	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
297246001714	TPP-binding site [chemical binding]; other site
297246001715	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
297246001716	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
297246001717	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
297246001718	E3 interaction surface; other site
297246001719	lipoyl attachment site [posttranslational modification]; other site
297246001720	e3 binding domain; Region: E3_binding; pfam02817
297246001721	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
297246001722	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
297246001723	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246001724	CoA-ligase; Region: Ligase_CoA; cl02894
297246001725	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
297246001726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001727	CoA-ligase; Region: Ligase_CoA; cl02894
297246001728	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
297246001729	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
297246001730	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
297246001731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001732	D-galactonate transporter; Region: 2A0114; TIGR00893
297246001733	putative substrate translocation pore; other site
297246001734	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
297246001735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420
297246001736	Helix-turn-helix domains; Region: HTH; cl00088
297246001737	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
297246001738	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
297246001739	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246001740	active site
297246001741	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
297246001742	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
297246001743	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
297246001744	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
297246001745	active site
297246001746	(T/H)XGH motif; other site
297246001747	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
297246001748	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
297246001749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001750	FAD dependent oxidoreductase; Region: DAO; pfam01266
297246001751	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246001752	ligand binding site [chemical binding]; other site
297246001753	flexible hinge region; other site
297246001754	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
297246001755	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
297246001756	putative acyl-acceptor binding pocket; other site
297246001757	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
297246001758	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
297246001759	active site
297246001760	DNA polymerase IV; Validated; Region: PRK02406
297246001761	DNA binding site [nucleotide binding]
297246001762	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
297246001763	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
297246001764	DNA binding site [nucleotide binding]
297246001765	catalytic residue [active]
297246001766	H2TH interface [polypeptide binding]; other site
297246001767	putative catalytic residues [active]
297246001768	turnover-facilitating residue; other site
297246001769	intercalation triad [nucleotide binding]; other site
297246001770	8OG recognition residue [nucleotide binding]; other site
297246001771	putative reading head residues; other site
297246001772	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
297246001773	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
297246001774	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
297246001775	Di-iron ligands [ion binding]; other site
297246001776	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246001777	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
297246001778	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001779	NAD(P) binding site [chemical binding]; other site
297246001780	active site
297246001781	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
297246001782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001783	NAD(P) binding site [chemical binding]; other site
297246001784	active site
297246001785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
297246001786	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
297246001787	Phasin protein; Region: Phasin_2; cl11491
297246001788	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
297246001789	Nucleoside recognition; Region: Gate; cl00486
297246001790	Nucleoside recognition; Region: Gate; cl00486
297246001791	putative peptidase; Provisional; Region: PRK11649
297246001792	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
297246001793	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
297246001794	active site
297246001795	HIGH motif; other site
297246001796	dimer interface [polypeptide binding]; other site
297246001797	KMSKS motif; other site
297246001798	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
297246001799	RNA binding surface [nucleotide binding]; other site
297246001800	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
297246001801	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
297246001802	trimer interface [polypeptide binding]; other site
297246001803	putative metal binding site [ion binding]; other site
297246001804	glutathione reductase; Validated; Region: PRK06116
297246001805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001806	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246001807	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
297246001808	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
297246001809	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246001810	active site
297246001811	Phosphate transporter family; Region: PHO4; cl00396
297246001812	Phosphate transporter family; Region: PHO4; cl00396
297246001813	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
297246001814	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
297246001815	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
297246001816	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
297246001817	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
297246001818	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
297246001819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001820	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
297246001821	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
297246001822	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246001823	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
297246001824	Membrane fusogenic activity; Region: BMFP; cl01115
297246001825	Nitrogen regulatory protein P-II; Region: P-II; cl00412
297246001826	Nitrogen regulatory protein P-II; Region: P-II; smart00938
297246001827	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
297246001828	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
297246001829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246001830	catalytic residue [active]
297246001831	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
297246001832	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
297246001833	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
297246001834	putative acyl-acceptor binding pocket; other site
297246001835	AMP-binding enzyme; Region: AMP-binding; cl15778
297246001836	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
297246001837	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
297246001838	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
297246001839	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
297246001840	Helix-turn-helix domains; Region: HTH; cl00088
297246001841	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
297246001842	putative ABC transporter; Region: ycf24; CHL00085
297246001843	FeS assembly ATPase SufC; Region: sufC; TIGR01978
297246001844	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
297246001845	Walker A/P-loop; other site
297246001846	ATP binding site [chemical binding]; other site
297246001847	Q-loop/lid; other site
297246001848	ABC transporter signature motif; other site
297246001849	Walker B; other site
297246001850	D-loop; other site
297246001851	H-loop/switch region; other site
297246001852	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
297246001853	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
297246001854	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
297246001855	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
297246001856	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
297246001857	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246001858	catalytic residue [active]
297246001859	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
297246001860	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
297246001861	trimerization site [polypeptide binding]; other site
297246001862	active site
297246001863	Domain of unknown function DUF59; Region: DUF59; cl00941
297246001864	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
297246001865	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
297246001866	motif 1; other site
297246001867	dimer interface [polypeptide binding]; other site
297246001868	active site
297246001869	motif 2; other site
297246001870	motif 3; other site
297246001871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246001872	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
297246001873	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
297246001874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001875	putative substrate translocation pore; other site
297246001876	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246001877	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
297246001878	Domain of unknown function DUF21; Region: DUF21; pfam01595
297246001879	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
297246001880	Transporter associated domain; Region: CorC_HlyC; cl08393
297246001881	probable cinnamyl alcohol dehydrogenase; Region: PLN02586
297246001882	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
297246001883	putative NAD(P) binding site [chemical binding]; other site
297246001884	putative substrate binding site [chemical binding]; other site
297246001885	catalytic Zn binding site [ion binding]; other site
297246001886	structural Zn binding site [ion binding]; other site
297246001887	dimer interface [polypeptide binding]; other site
297246001888	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
297246001889	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
297246001890	active site
297246001891	catalytic residues [active]
297246001892	metal binding site [ion binding]; metal-binding site
297246001893	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
297246001894	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
297246001895	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
297246001896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001897	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
297246001898	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
297246001899	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
297246001900	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
297246001901	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
297246001902	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
297246001903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246001904	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
297246001905	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
297246001906	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
297246001907	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
297246001908	Competence protein; Region: Competence; cl00471
297246001909	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246001910	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246001911	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
297246001912	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
297246001913	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
297246001914	PilX N-terminal; Region: PilX_N; pfam14341
297246001915	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
297246001916	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246001917	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
297246001918	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246001919	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246001920	Type II transport protein GspH; Region: GspH; pfam12019
297246001921	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
297246001922	NodB motif; other site
297246001923	putative active site [active]
297246001924	putative catalytic site [active]
297246001925	putative Zn binding site [ion binding]; other site
297246001926	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
297246001927	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
297246001928	thymidine kinase; Provisional; Region: PRK04296
297246001929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001930	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246001931	putative substrate translocation pore; other site
297246001932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001933	putative substrate translocation pore; other site
297246001934	D-galactonate transporter; Region: 2A0114; TIGR00893
297246001935	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
297246001936	Sulfatase; Region: Sulfatase; cl10460
297246001937	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
297246001938	active site
297246001939	HslU subunit interaction site [polypeptide binding]; other site
297246001940	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
297246001941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246001942	Walker A motif; other site
297246001943	ATP binding site [chemical binding]; other site
297246001944	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246001945	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
297246001946	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
297246001947	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
297246001948	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
297246001949	metal ion-dependent adhesion site (MIDAS); other site
297246001950	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
297246001951	type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
297246001952	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
297246001953	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
297246001954	putative active site [active]
297246001955	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
297246001956	putative active site [active]
297246001957	putative DNA binding site [nucleotide binding]; other site
297246001958	putative phosphate binding site [ion binding]; other site
297246001959	putative catalytic site [active]
297246001960	metal binding site A [ion binding]; metal-binding site
297246001961	putative AP binding site [nucleotide binding]; other site
297246001962	putative metal binding site B [ion binding]; other site
297246001963	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
297246001964	putative phosphate binding site [ion binding]; other site
297246001965	putative catalytic site [active]
297246001966	active site
297246001967	metal binding site A [ion binding]; metal-binding site
297246001968	DNA binding site [nucleotide binding]
297246001969	putative AP binding site [nucleotide binding]; other site
297246001970	putative metal binding site B [ion binding]; other site
297246001971	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
297246001972	Malic enzyme, N-terminal domain; Region: malic; pfam00390
297246001973	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
297246001974	putative NAD(P) binding site [chemical binding]; other site
297246001975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001976	putative substrate translocation pore; other site
297246001977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246001978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246001979	putative substrate translocation pore; other site
297246001980	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246001981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246001982	Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776
297246001983	aromatic amino acid transport protein; Region: araaP; TIGR00837
297246001984	Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776
297246001985	aromatic amino acid transport protein; Region: araaP; TIGR00837
297246001986	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246001987	ligand binding site [chemical binding]; other site
297246001988	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001989	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
297246001990	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246001991	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
297246001992	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
297246001993	Walker A/P-loop; other site
297246001994	ATP binding site [chemical binding]; other site
297246001995	Q-loop/lid; other site
297246001996	ABC transporter signature motif; other site
297246001997	Walker B; other site
297246001998	D-loop; other site
297246001999	H-loop/switch region; other site
297246002000	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
297246002001	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002002	Walker A/P-loop; other site
297246002003	ATP binding site [chemical binding]; other site
297246002004	Q-loop/lid; other site
297246002005	ABC transporter signature motif; other site
297246002006	Walker B; other site
297246002007	D-loop; other site
297246002008	H-loop/switch region; other site
297246002009	ABC-2 type transporter; Region: ABC2_membrane; cl11417
297246002010	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246002011	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246002012	GIY-YIG motif/motif A; other site
297246002013	putative active site [active]
297246002014	putative metal binding site [ion binding]; other site
297246002015	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
297246002016	ABC-2 type transporter; Region: ABC2_membrane; cl11417
297246002017	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246002018	lytic murein transglycosylase; Provisional; Region: PRK11619
297246002019	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
297246002020	N-acetyl-D-glucosamine binding site [chemical binding]; other site
297246002021	catalytic residue [active]
297246002022	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
297246002023	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
297246002024	substrate binding site [chemical binding]; other site
297246002025	hexamer interface [polypeptide binding]; other site
297246002026	metal binding site [ion binding]; metal-binding site
297246002027	DoxX; Region: DoxX; cl00976
297246002028	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
297246002029	Protein of unknown function (DUF692); Region: DUF692; cl01263
297246002030	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
297246002031	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
297246002032	nucleophile elbow; other site
297246002033	DoxX; Region: DoxX; cl00976
297246002034	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
297246002035	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246002036	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
297246002037	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
297246002038	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
297246002039	cyclase homology domain; Region: CHD; cd07302
297246002040	nucleotidyl binding site; other site
297246002041	metal binding site [ion binding]; metal-binding site
297246002042	dimer interface [polypeptide binding]; other site
297246002043	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
297246002044	Protein of unknown function (DUF692); Region: DUF692; cl01263
297246002045	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246002046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246002047	substrate binding pocket [chemical binding]; other site
297246002048	membrane-bound complex binding site; other site
297246002049	hinge residues; other site
297246002050	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
297246002051	metal binding triad; other site
297246002052	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
297246002053	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
297246002054	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
297246002055	metal binding triad; other site
297246002056	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
297246002057	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246002058	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
297246002059	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002060	Walker A/P-loop; other site
297246002061	ATP binding site [chemical binding]; other site
297246002062	Q-loop/lid; other site
297246002063	ABC transporter signature motif; other site
297246002064	Walker B; other site
297246002065	D-loop; other site
297246002066	H-loop/switch region; other site
297246002067	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
297246002068	ABC-2 type transporter; Region: ABC2_membrane; cl11417
297246002069	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
297246002070	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
297246002071	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246002072	FeS/SAM binding site; other site
297246002073	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
297246002074	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
297246002075	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
297246002076	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
297246002077	DsbD alpha interface [polypeptide binding]; other site
297246002078	catalytic residues [active]
297246002079	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
297246002080	oligomerisation interface [polypeptide binding]; other site
297246002081	mobile loop; other site
297246002082	roof hairpin; other site
297246002083	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
297246002084	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
297246002085	ring oligomerisation interface [polypeptide binding]; other site
297246002086	ATP/Mg binding site [chemical binding]; other site
297246002087	stacking interactions; other site
297246002088	hinge regions; other site
297246002089	Ferritin-like domain; Region: Ferritin; pfam00210
297246002090	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
297246002091	dimerization interface [polypeptide binding]; other site
297246002092	DPS ferroxidase diiron center [ion binding]; other site
297246002093	ion pore; other site
297246002094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246002095	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
297246002096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
297246002097	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
297246002098	anchoring element; other site
297246002099	dimer interface [polypeptide binding]; other site
297246002100	ATP binding site [chemical binding]; other site
297246002101	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
297246002102	active site
297246002103	metal binding site [ion binding]; metal-binding site
297246002104	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
297246002105	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
297246002106	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
297246002107	Walker A/P-loop; other site
297246002108	ATP binding site [chemical binding]; other site
297246002109	Q-loop/lid; other site
297246002110	ABC transporter signature motif; other site
297246002111	Walker B; other site
297246002112	D-loop; other site
297246002113	H-loop/switch region; other site
297246002114	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
297246002115	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
297246002116	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
297246002117	Walker A/P-loop; other site
297246002118	ATP binding site [chemical binding]; other site
297246002119	Q-loop/lid; other site
297246002120	ABC transporter signature motif; other site
297246002121	Walker B; other site
297246002122	D-loop; other site
297246002123	H-loop/switch region; other site
297246002124	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
297246002125	prolyl-tRNA synthetase; Provisional; Region: PRK09194
297246002126	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
297246002127	dimer interface [polypeptide binding]; other site
297246002128	motif 1; other site
297246002129	active site
297246002130	motif 2; other site
297246002131	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
297246002132	putative deacylase active site [active]
297246002133	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
297246002134	active site
297246002135	motif 3; other site
297246002136	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
297246002137	anticodon binding site; other site
297246002138	Fic family protein [Function unknown]; Region: COG3177
297246002139	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246002140	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246002141	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246002142	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246002143	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246002144	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246002145	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246002146	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246002147	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
297246002148	Sulfate transporter family; Region: Sulfate_transp; cl15842
297246002149	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
297246002150	active site clefts [active]
297246002151	zinc binding site [ion binding]; other site
297246002152	dimer interface [polypeptide binding]; other site
297246002153	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
297246002154	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
297246002155	Ligand Binding Site [chemical binding]; other site
297246002156	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
297246002157	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
297246002158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246002159	S-adenosylmethionine binding site [chemical binding]; other site
297246002160	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
297246002161	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
297246002162	substrate-cofactor binding pocket; other site
297246002163	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246002164	catalytic residue [active]
297246002165	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
297246002166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002167	NAD(P) binding site [chemical binding]; other site
297246002168	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
297246002169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002170	Walker A/P-loop; other site
297246002171	ATP binding site [chemical binding]; other site
297246002172	Q-loop/lid; other site
297246002173	ABC transporter signature motif; other site
297246002174	Walker B; other site
297246002175	D-loop; other site
297246002176	H-loop/switch region; other site
297246002177	ABC transporter; Region: ABC_tran_2; pfam12848
297246002178	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246002179	hypothetical protein; Provisional; Region: PRK06132
297246002180	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246002181	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
297246002182	Sulphur transport; Region: Sulf_transp; cl01018
297246002183	Predicted transporter component [General function prediction only]; Region: COG2391
297246002184	Sulphur transport; Region: Sulf_transp; cl01018
297246002185	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246002186	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246002187	Arginase family; Region: Arginase; cl00306
297246002188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002189	short chain dehydrogenase; Provisional; Region: PRK06924
297246002190	NAD(P) binding site [chemical binding]; other site
297246002191	active site
297246002192	imidazolonepropionase; Validated; Region: PRK09356
297246002193	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
297246002194	active site
297246002195	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
297246002196	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
297246002197	OPT oligopeptide transporter protein; Region: OPT; cl14607
297246002198	oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728
297246002199	similar to  integrase;hypothetical protein
297246002200	similar to transposase, partial;hypothetical protein
297246002201	Transposase domain (DUF772); Region: DUF772; cl15789
297246002202	Similar to transposase (IS5 family);hypothetical protein
297246002203	similar to transposase, partial;hypothetical protein
297246002204	similar to tranposase, partial;hypothetical protein
297246002205	similar to transposase;hypothetical protein
297246002206	Similar to transposase, partial;hypothetical protein
297246002207	similar to tranposase;hypothetical protein
297246002208	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
297246002209	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
297246002210	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373
297246002211	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
297246002212	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246002213	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
297246002214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246002215	dimer interface [polypeptide binding]; other site
297246002216	phosphorylation site [posttranslational modification]
297246002217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246002218	ATP binding site [chemical binding]; other site
297246002219	Mg2+ binding site [ion binding]; other site
297246002220	G-X-G motif; other site
297246002221	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
297246002222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246002223	active site
297246002224	phosphorylation site [posttranslational modification]
297246002225	intermolecular recognition site; other site
297246002226	dimerization interface [polypeptide binding]; other site
297246002227	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
297246002228	DNA binding site [nucleotide binding]
297246002229	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
297246002230	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
297246002231	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
297246002232	HIGH motif; other site
297246002233	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
297246002234	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
297246002235	active site
297246002236	KMSKS motif; other site
297246002237	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
297246002238	tRNA binding surface [nucleotide binding]; other site
297246002239	anticodon binding site; other site
297246002240	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
297246002241	multidrug efflux protein; Reviewed; Region: PRK09579
297246002242	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
297246002243	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246002244	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246002245	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246002246	BON domain; Region: BON; cl02771
297246002247	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
297246002248	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
297246002249	dimer interface [polypeptide binding]; other site
297246002250	glycine-pyridoxal phosphate binding site [chemical binding]; other site
297246002251	active site
297246002252	folate binding site [chemical binding]; other site
297246002253	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
297246002254	ATP cone domain; Region: ATP-cone; pfam03477
297246002255	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
297246002256	putative RNA binding site [nucleotide binding]; other site
297246002257	thiamine monophosphate kinase; Provisional; Region: PRK05731
297246002258	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
297246002259	ATP binding site [chemical binding]; other site
297246002260	dimerization interface [polypeptide binding]; other site
297246002261	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
297246002262	tetramer interfaces [polypeptide binding]; other site
297246002263	binuclear metal-binding site [ion binding]; other site
297246002264	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
297246002265	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246002266	NAD synthetase; Provisional; Region: PRK13981
297246002267	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
297246002268	multimer interface [polypeptide binding]; other site
297246002269	active site
297246002270	catalytic triad [active]
297246002271	protein interface 1 [polypeptide binding]; other site
297246002272	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
297246002273	homodimer interface [polypeptide binding]; other site
297246002274	NAD binding pocket [chemical binding]; other site
297246002275	ATP binding pocket [chemical binding]; other site
297246002276	Mg binding site [ion binding]; other site
297246002277	active-site loop [active]
297246002278	Uncharacterized conserved protein [Function unknown]; Region: COG4715
297246002279	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
297246002280	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246002281	ATP binding site [chemical binding]; other site
297246002282	putative Mg++ binding site [ion binding]; other site
297246002283	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246002284	nucleotide binding region [chemical binding]; other site
297246002285	ATP-binding site [chemical binding]; other site
297246002286	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
297246002287	replicative DNA helicase; Region: DnaB; TIGR00665
297246002288	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
297246002289	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
297246002290	Walker A motif; other site
297246002291	ATP binding site [chemical binding]; other site
297246002292	Walker B motif; other site
297246002293	DNA binding loops [nucleotide binding]
297246002294	alanine racemase; Reviewed; Region: alr; PRK00053
297246002295	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
297246002296	active site
297246002297	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
297246002298	substrate binding site [chemical binding]; other site
297246002299	catalytic residues [active]
297246002300	dimer interface [polypeptide binding]; other site
297246002301	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
297246002302	FOG: CBS domain [General function prediction only]; Region: COG0517
297246002303	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
297246002304	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
297246002305	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
297246002306	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
297246002307	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
297246002308	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246002309	metal binding site [ion binding]; metal-binding site
297246002310	active site
297246002311	I-site; other site
297246002312	lipoyl synthase; Provisional; Region: PRK05481
297246002313	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246002314	FeS/SAM binding site; other site
297246002315	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
297246002316	GIY-YIG motif/motif A; other site
297246002317	putative active site [active]
297246002318	putative metal binding site [ion binding]; other site
297246002319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246002320	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
297246002321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002322	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
297246002323	Ligand Binding Site [chemical binding]; other site
297246002324	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
297246002325	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
297246002326	substrate binding site [chemical binding]; other site
297246002327	glutamase interaction surface [polypeptide binding]; other site
297246002328	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
297246002329	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
297246002330	putative active site [active]
297246002331	oxyanion strand; other site
297246002332	catalytic triad [active]
297246002333	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
297246002334	ligand binding site; other site
297246002335	tetramer interface; other site
297246002336	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
297246002337	NeuB family; Region: NeuB; cl00496
297246002338	SAF domain; Region: SAF; cl00555
297246002339	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
297246002340	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
297246002341	active site
297246002342	homodimer interface [polypeptide binding]; other site
297246002343	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
297246002344	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
297246002345	putative trimer interface [polypeptide binding]; other site
297246002346	putative CoA binding site [chemical binding]; other site
297246002347	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
297246002348	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
297246002349	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
297246002350	inhibitor-cofactor binding pocket; inhibition site
297246002351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246002352	catalytic residue [active]
297246002353	Cupin domain; Region: Cupin_2; cl09118
297246002354	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
297246002355	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
297246002356	NADP binding site [chemical binding]; other site
297246002357	active site
297246002358	putative substrate binding site [chemical binding]; other site
297246002359	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
297246002360	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
297246002361	NAD binding site [chemical binding]; other site
297246002362	substrate binding site [chemical binding]; other site
297246002363	homodimer interface [polypeptide binding]; other site
297246002364	active site
297246002365	Phosphoglucose isomerase; Region: PGI; pfam00342
297246002366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002367	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
297246002368	active site
297246002369	dimer interface [polypeptide binding]; other site
297246002370	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
297246002371	dimer interface [polypeptide binding]; other site
297246002372	active site
297246002373	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
297246002374	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
297246002375	substrate binding site; other site
297246002376	tetramer interface; other site
297246002377	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
297246002378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002379	NAD(P) binding site [chemical binding]; other site
297246002380	active site
297246002381	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
297246002382	Mg++ binding site [ion binding]; other site
297246002383	putative catalytic motif [active]
297246002384	putative substrate binding site [chemical binding]; other site
297246002385	Similar to N-terminal part of Legionella hypothetical protein;hypothetical protein
297246002386	Similar to central part of Legionella hypothetical protein;hypothetical protein
297246002387	Similar to C-terminal part of Legionella hypothetical protein;hypothetical protein
297246002388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246002389	binding surface
297246002390	TPR motif; other site
297246002391	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246002392	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246002393	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
297246002394	NeuB family; Region: NeuB; cl00496
297246002395	SAF domain; Region: SAF; cl00555
297246002396	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
297246002397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246002398	S-adenosylmethionine binding site [chemical binding]; other site
297246002399	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
297246002400	ABC-2 type transporter; Region: ABC2_membrane; cl11417
297246002401	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
297246002402	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
297246002403	Walker A/P-loop; other site
297246002404	ATP binding site [chemical binding]; other site
297246002405	Q-loop/lid; other site
297246002406	ABC transporter signature motif; other site
297246002407	Walker B; other site
297246002408	D-loop; other site
297246002409	H-loop/switch region; other site
297246002410	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
297246002411	putative carbohydrate binding site [chemical binding]; other site
297246002412	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
297246002413	Probable Catalytic site; other site
297246002414	metal-binding site
297246002415	Acyltransferase family; Region: Acyl_transf_3; pfam01757
297246002416	OpgC protein; Region: OpgC_C; cl00792
297246002417	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
297246002418	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
297246002419	Probable Catalytic site; other site
297246002420	metal-binding site
297246002421	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
297246002422	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
297246002423	Probable Catalytic site; other site
297246002424	metal-binding site
297246002425	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246002426	Global regulator protein family; Region: CsrA; cl00670
297246002427	OpgC protein; Region: OpgC_C; cl00792
297246002428	Acyltransferase family; Region: Acyl_transf_3; pfam01757
297246002429	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
297246002430	Helix-turn-helix domains; Region: HTH; cl00088
297246002431	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
297246002432	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
297246002433	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
297246002434	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
297246002435	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246002436	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
297246002437	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
297246002438	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
297246002439	Ligand Binding Site [chemical binding]; other site
297246002440	TilS substrate binding domain; Region: TilS; pfam09179
297246002441	B3/4 domain; Region: B3_4; cl11458
297246002442	Transposase IS200 like; Region: Y1_Tnp; cl00848
297246002443	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
297246002444	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
297246002445	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
297246002446	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
297246002447	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
297246002448	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
297246002449	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
297246002450	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
297246002451	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
297246002452	muropeptide transporter; Validated; Region: ampG; PRK11010
297246002453	muropeptide transporter; Reviewed; Region: ampG; PRK11902
297246002454	Helix-turn-helix domains; Region: HTH; cl00088
297246002455	similar to transposase, partial;hypothetical protein
297246002456	similar to transposase, partial;hypothetical protein
297246002457	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
297246002458	Quinolinate synthetase A protein; Region: NadA; cl00420
297246002459	L-aspartate oxidase; Provisional; Region: PRK09077
297246002460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002461	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
297246002462	adenylosuccinate lyase; Provisional; Region: PRK09285
297246002463	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
297246002464	tetramer interface [polypeptide binding]; other site
297246002465	active site
297246002466	Sulfate transporter family; Region: Sulfate_transp; cl15842
297246002467	putative transporter; Provisional; Region: PRK11660
297246002468	Sulfate transporter family; Region: Sulfate_transp; cl15842
297246002469	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
297246002470	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
297246002471	active site
297246002472	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
297246002473	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
297246002474	active site
297246002475	phosphoenolpyruvate synthase; Validated; Region: PRK06464
297246002476	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
297246002477	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
297246002478	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
297246002479	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
297246002480	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
297246002481	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
297246002482	dimerization interface [polypeptide binding]; other site
297246002483	active site
297246002484	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
297246002485	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
297246002486	active site
297246002487	homodimer interface [polypeptide binding]; other site
297246002488	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
297246002489	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
297246002490	metal binding site [ion binding]; metal-binding site
297246002491	putative dimer interface [polypeptide binding]; other site
297246002492	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
297246002493	rod shape-determining protein MreB; Provisional; Region: PRK13927
297246002494	hypothetical protein; Provisional; Region: PRK10039
297246002495	Cell division protein FtsA; Region: FtsA; cl11496
297246002496	rod shape-determining protein MreC; Provisional; Region: PRK13922
297246002497	rod shape-determining protein MreC; Region: MreC; pfam04085
297246002498	rod shape-determining protein MreD; Region: MreD; cl01087
297246002499	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
297246002500	pseudouridine synthase; Region: TIGR00093
297246002501	active site
297246002502	isocitrate dehydrogenase; Validated; Region: PRK07362
297246002503	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
297246002504	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
297246002505	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
297246002506	Clp amino terminal domain; Region: Clp_N; pfam02861
297246002507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246002508	Walker A motif; other site
297246002509	ATP binding site [chemical binding]; other site
297246002510	Walker B motif; other site
297246002511	arginine finger; other site
297246002512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246002513	Walker A motif; other site
297246002514	ATP binding site [chemical binding]; other site
297246002515	Walker B motif; other site
297246002516	arginine finger; other site
297246002517	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
297246002518	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246002519	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246002520	GIY-YIG motif/motif A; other site
297246002521	putative active site [active]
297246002522	putative metal binding site [ion binding]; other site
297246002523	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
297246002524	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
297246002525	putative metal binding site; other site
297246002526	Rhomboid family; Region: Rhomboid; cl11446
297246002527	Peptidase family M23; Region: Peptidase_M23; pfam01551
297246002528	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
297246002529	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
297246002530	generic binding surface II; other site
297246002531	generic binding surface I; other site
297246002532	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
297246002533	Sporulation related domain; Region: SPOR; cl10051
297246002534	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
297246002535	biofilm formation regulator HmsP; Provisional; Region: PRK11829
297246002536	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
297246002537	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246002538	metal binding site [ion binding]; metal-binding site
297246002539	active site
297246002540	I-site; other site
297246002541	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246002542	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
297246002543	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
297246002544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002545	hypothetical protein; Provisional; Region: PRK06194
297246002546	classical (c) SDRs; Region: SDR_c; cd05233
297246002547	NAD(P) binding site [chemical binding]; other site
297246002548	active site
297246002549	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
297246002550	active site
297246002551	ribulose/triose binding site [chemical binding]; other site
297246002552	phosphate binding site [ion binding]; other site
297246002553	substrate (anthranilate) binding pocket [chemical binding]; other site
297246002554	product (indole) binding pocket [chemical binding]; other site
297246002555	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
297246002556	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
297246002557	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
297246002558	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
297246002559	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
297246002560	glutamine binding [chemical binding]; other site
297246002561	catalytic triad [active]
297246002562	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
297246002563	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
297246002564	Walker A/P-loop; other site
297246002565	ATP binding site [chemical binding]; other site
297246002566	Q-loop/lid; other site
297246002567	ABC transporter signature motif; other site
297246002568	Walker B; other site
297246002569	D-loop; other site
297246002570	H-loop/switch region; other site
297246002571	OstA-like protein; Region: OstA; cl00844
297246002572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
297246002573	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246002574	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
297246002575	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
297246002576	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
297246002577	putative active site [active]
297246002578	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
297246002579	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
297246002580	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
297246002581	Walker A/P-loop; other site
297246002582	ATP binding site [chemical binding]; other site
297246002583	Q-loop/lid; other site
297246002584	ABC transporter signature motif; other site
297246002585	Walker B; other site
297246002586	D-loop; other site
297246002587	H-loop/switch region; other site
297246002588	Permease; Region: Permease; cl00510
297246002589	mce related protein; Region: MCE; pfam02470
297246002590	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
297246002591	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
297246002592	anti sigma factor interaction site; other site
297246002593	regulatory phosphorylation site [posttranslational modification]; other site
297246002594	BolA-like protein; Region: BolA; cl00386
297246002595	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
297246002596	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
297246002597	hinge; other site
297246002598	active site
297246002599	Uncharacterized conserved protein [Function unknown]; Region: COG0327
297246002600	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
297246002601	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
297246002602	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
297246002603	Walker A/P-loop; other site
297246002604	ATP binding site [chemical binding]; other site
297246002605	Q-loop/lid; other site
297246002606	ABC transporter signature motif; other site
297246002607	Walker B; other site
297246002608	D-loop; other site
297246002609	H-loop/switch region; other site
297246002610	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
297246002611	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
297246002612	FtsX-like permease family; Region: FtsX; cl15850
297246002613	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246002614	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246002615	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246002616	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
297246002617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
297246002618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246002619	Walker A motif; other site
297246002620	ATP binding site [chemical binding]; other site
297246002621	Walker B motif; other site
297246002622	arginine finger; other site
297246002623	Helix-turn-helix domains; Region: HTH; cl00088
297246002624	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
297246002625	putative inner membrane peptidase; Provisional; Region: PRK11778
297246002626	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
297246002627	tandem repeat interface [polypeptide binding]; other site
297246002628	oligomer interface [polypeptide binding]; other site
297246002629	active site residues [active]
297246002630	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540
297246002631	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002632	Walker A/P-loop; other site
297246002633	ATP binding site [chemical binding]; other site
297246002634	Q-loop/lid; other site
297246002635	ABC transporter signature motif; other site
297246002636	Walker B; other site
297246002637	D-loop; other site
297246002638	H-loop/switch region; other site
297246002639	CcmB protein; Region: CcmB; cl01016
297246002640	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
297246002641	Heme exporter protein D (CcmD); Region: CcmD; cl11475
297246002642	CcmE; Region: CcmE; cl00994
297246002643	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
297246002644	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
297246002645	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
297246002646	catalytic residues [active]
297246002647	central insert; other site
297246002648	Cytochrome C biogenesis protein; Region: CcmH; cl01179
297246002649	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
297246002650	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246002651	binding surface
297246002652	TPR motif; other site
297246002653	Dodecin; Region: Dodecin; cl01328
297246002654	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
297246002655	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
297246002656	active site
297246002657	DNA binding site [nucleotide binding]
297246002658	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002659	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
297246002660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246002661	ATP binding site [chemical binding]; other site
297246002662	ATP binding site [chemical binding]; other site
297246002663	putative Mg++ binding site [ion binding]; other site
297246002664	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246002665	nucleotide binding region [chemical binding]; other site
297246002666	ATP-binding site [chemical binding]; other site
297246002667	RQC domain; Region: RQC; cl09632
297246002668	HRDC domain; Region: HRDC; cl02578
297246002669	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
297246002670	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
297246002671	active site
297246002672	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
297246002673	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
297246002674	substrate binding site [chemical binding]; other site
297246002675	oxyanion hole (OAH) forming residues; other site
297246002676	trimer interface [polypeptide binding]; other site
297246002677	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
297246002678	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
297246002679	substrate binding site [chemical binding]; other site
297246002680	oxyanion hole (OAH) forming residues; other site
297246002681	trimer interface [polypeptide binding]; other site
297246002682	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
297246002683	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
297246002684	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
297246002685	G1 box; other site
297246002686	putative GEF interaction site [polypeptide binding]; other site
297246002687	GTP/Mg2+ binding site [chemical binding]; other site
297246002688	Switch I region; other site
297246002689	G2 box; other site
297246002690	G3 box; other site
297246002691	Switch II region; other site
297246002692	G4 box; other site
297246002693	G5 box; other site
297246002694	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
297246002695	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
297246002696	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
297246002697	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
297246002698	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
297246002699	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
297246002700	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002701	NAD(P) binding site [chemical binding]; other site
297246002702	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
297246002703	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246002704	metal binding site [ion binding]; metal-binding site
297246002705	active site
297246002706	I-site; other site
297246002707	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
297246002708	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
297246002709	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
297246002710	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
297246002711	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
297246002712	metal binding site [ion binding]; metal-binding site
297246002713	dimer interface [polypeptide binding]; other site
297246002714	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
297246002715	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
297246002716	trimer interface [polypeptide binding]; other site
297246002717	active site
297246002718	substrate binding site [chemical binding]; other site
297246002719	CoA binding site [chemical binding]; other site
297246002720	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
297246002721	putative acyl-acceptor binding pocket; other site
297246002722	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
297246002723	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
297246002724	homodimer interface [polypeptide binding]; other site
297246002725	substrate-cofactor binding pocket; other site
297246002726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246002727	catalytic residue [active]
297246002728	PAS fold; Region: PAS_7; pfam12860
297246002729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246002730	PAS domain; Region: PAS_9; pfam13426
297246002731	putative active site [active]
297246002732	heme pocket [chemical binding]; other site
297246002733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246002734	metal binding site [ion binding]; metal-binding site
297246002735	active site
297246002736	I-site; other site
297246002737	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246002738	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
297246002739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002740	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
297246002741	FAD binding domain; Region: FAD_binding_4; pfam01565
297246002742	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
297246002743	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
297246002744	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246002745	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
297246002746	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
297246002747	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
297246002748	adenine DNA glycosylase; Provisional; Region: PRK10880
297246002749	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
297246002750	minor groove reading motif; other site
297246002751	helix-hairpin-helix signature motif; other site
297246002752	substrate binding pocket [chemical binding]; other site
297246002753	active site
297246002754	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
297246002755	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
297246002756	DNA binding and oxoG recognition site [nucleotide binding]
297246002757	AsmA family; Region: AsmA; pfam05170
297246002758	AsmA-like C-terminal region; Region: AsmA_2; cl15864
297246002759	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
297246002760	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
297246002761	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
297246002762	protein binding site [polypeptide binding]; other site
297246002763	Isochorismatase family; Region: Isochorismatase; pfam00857
297246002764	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
297246002765	catalytic triad [active]
297246002766	dimer interface [polypeptide binding]; other site
297246002767	conserved cis-peptide bond; other site
297246002768	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
297246002769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002770	NAD(P) binding site [chemical binding]; other site
297246002771	active site
297246002772	FlgN protein; Region: FlgN; cl09176
297246002773	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
297246002774	SAF domain; Region: SAF; cl00555
297246002775	SAF-like; Region: SAF_2; pfam13144
297246002776	Cytochrome c; Region: Cytochrom_C; cl11414
297246002777	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246002778	Type III pantothenate kinase; Region: Pan_kinase; cl09130
297246002779	cell division protein MraZ; Reviewed; Region: PRK00326
297246002780	MraZ protein; Region: MraZ; pfam02381
297246002781	MraZ protein; Region: MraZ; pfam02381
297246002782	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
297246002783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002784	Septum formation initiator; Region: DivIC; cl11433
297246002785	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
297246002786	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
297246002787	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246002788	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
297246002789	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
297246002790	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
297246002791	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246002792	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
297246002793	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002794	Domain of unknown function (DUF3410); Region: DUF3410; pfam11890
297246002795	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
297246002796	active site
297246002797	putative substrate binding region [chemical binding]; other site
297246002798	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
297246002799	active site
297246002800	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
297246002801	Ligand binding site [chemical binding]; other site
297246002802	Electron transfer flavoprotein domain; Region: ETF; pfam01012
297246002803	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
297246002804	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
297246002805	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
297246002806	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
297246002807	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
297246002808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246002809	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
297246002810	Transglycosylase; Region: Transgly; cl07896
297246002811	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246002812	Cell division protein FtsA; Region: FtsA; cl11496
297246002813	Competence protein A; Region: Competence_A; pfam11104
297246002814	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
297246002815	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
297246002816	Pilus assembly protein, PilO; Region: PilO; cl01234
297246002817	Pilus assembly protein, PilP; Region: PilP; cl01235
297246002818	AMIN domain; Region: AMIN; pfam11741
297246002819	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
297246002820	Secretin and TonB N terminus short domain; Region: STN; cl06624
297246002821	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
297246002822	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
297246002823	shikimate kinase; Reviewed; Region: aroK; PRK00131
297246002824	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
297246002825	ADP binding site [chemical binding]; other site
297246002826	magnesium binding site [ion binding]; other site
297246002827	putative shikimate binding site; other site
297246002828	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
297246002829	active site
297246002830	dimer interface [polypeptide binding]; other site
297246002831	metal binding site [ion binding]; metal-binding site
297246002832	AAA domain; Region: AAA_22; pfam13401
297246002833	Sporulation related domain; Region: SPOR; cl10051
297246002834	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
297246002835	Ligand Binding Site [chemical binding]; other site
297246002836	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
297246002837	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
297246002838	active site
297246002839	Riboflavin kinase; Region: Flavokinase; cl03312
297246002840	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
297246002841	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246002842	active site
297246002843	HIGH motif; other site
297246002844	nucleotide binding site [chemical binding]; other site
297246002845	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
297246002846	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
297246002847	active site
297246002848	KMSKS motif; other site
297246002849	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
297246002850	tRNA binding surface [nucleotide binding]; other site
297246002851	anticodon binding site; other site
297246002852	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
297246002853	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
297246002854	lipoprotein signal peptidase; Provisional; Region: PRK14787
297246002855	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
297246002856	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
297246002857	catalytic residue [active]
297246002858	GTPase Era; Reviewed; Region: era; PRK00089
297246002859	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
297246002860	G1 box; other site
297246002861	GTP/Mg2+ binding site [chemical binding]; other site
297246002862	Switch I region; other site
297246002863	G2 box; other site
297246002864	Switch II region; other site
297246002865	G3 box; other site
297246002866	G4 box; other site
297246002867	G5 box; other site
297246002868	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
297246002869	Recombination protein O N terminal; Region: RecO_N; cl15812
297246002870	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
297246002871	Recombination protein O C terminal; Region: RecO_C; pfam02565
297246002872	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246002873	Leucine-rich repeats; other site
297246002874	Substrate binding site [chemical binding]; other site
297246002875	Leucine rich repeat; Region: LRR_8; pfam13855
297246002876	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
297246002877	active site
297246002878	hydrophilic channel; other site
297246002879	dimerization interface [polypeptide binding]; other site
297246002880	catalytic residues [active]
297246002881	active site lid [active]
297246002882	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
297246002883	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
297246002884	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
297246002885	dimer interface [polypeptide binding]; other site
297246002886	PYR/PP interface [polypeptide binding]; other site
297246002887	TPP binding site [chemical binding]; other site
297246002888	substrate binding site [chemical binding]; other site
297246002889	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
297246002890	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
297246002891	TPP-binding site [chemical binding]; other site
297246002892	YccA-like proteins; Region: YccA_like; cd10433
297246002893	Predicted amidohydrolase [General function prediction only]; Region: COG0388
297246002894	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
297246002895	putative active site [active]
297246002896	catalytic triad [active]
297246002897	dimer interface [polypeptide binding]; other site
297246002898	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
297246002899	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
297246002900	hypothetical protein; Provisional; Region: PRK10279
297246002901	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
297246002902	active site
297246002903	nucleophile elbow; other site
297246002904	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
297246002905	AMP-binding enzyme; Region: AMP-binding; cl15778
297246002906	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
297246002907	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
297246002908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246002909	ATP binding site [chemical binding]; other site
297246002910	putative Mg++ binding site [ion binding]; other site
297246002911	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246002912	nucleotide binding region [chemical binding]; other site
297246002913	ATP-binding site [chemical binding]; other site
297246002914	TRCF domain; Region: TRCF; cl04088
297246002915	RmuC family; Region: RmuC; pfam02646
297246002916	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
297246002917	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
297246002918	nucleotide binding pocket [chemical binding]; other site
297246002919	K-X-D-G motif; other site
297246002920	catalytic site [active]
297246002921	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
297246002922	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
297246002923	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
297246002924	Dimer interface [polypeptide binding]; other site
297246002925	BRCT sequence motif; other site
297246002926	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
297246002927	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
297246002928	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
297246002929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246002930	dimer interface [polypeptide binding]; other site
297246002931	conserved gate region; other site
297246002932	putative PBP binding loops; other site
297246002933	ABC-ATPase subunit interface; other site
297246002934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246002935	dimer interface [polypeptide binding]; other site
297246002936	conserved gate region; other site
297246002937	putative PBP binding loops; other site
297246002938	ABC-ATPase subunit interface; other site
297246002939	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
297246002940	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
297246002941	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
297246002942	generic binding surface II; other site
297246002943	generic binding surface I; other site
297246002944	UbiA prenyltransferase family; Region: UbiA; cl00337
297246002945	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
297246002946	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
297246002947	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
297246002948	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
297246002949	NAD(P) binding site [chemical binding]; other site
297246002950	homodimer interface [polypeptide binding]; other site
297246002951	substrate binding site [chemical binding]; other site
297246002952	active site
297246002953	Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833
297246002954	GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl02218
297246002955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
297246002956	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246002957	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246002958	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
297246002959	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
297246002960	Catalytic site [active]
297246002961	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
297246002962	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
297246002963	active site
297246002964	DNA binding site [nucleotide binding]
297246002965	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
297246002966	Antirestriction protein (ArdA); Region: ArdA; cl01953
297246002967	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
297246002968	dimer interface [polypeptide binding]; other site
297246002969	ssDNA binding site [nucleotide binding]; other site
297246002970	tetramer (dimer of dimers) interface [polypeptide binding]; other site
297246002971	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
297246002972	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
297246002973	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
297246002974	similar to unknown protein;hypothetical protein
297246002975	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
297246002976	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246002977	Walker A motif; other site
297246002978	ATP binding site [chemical binding]; other site
297246002979	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
297246002980	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
297246002981	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
297246002982	TraU protein; Region: TraU; cl06067
297246002983	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
297246002984	Domain of unknown function DUF87; Region: DUF87; pfam01935
297246002985	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
297246002986	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
297246002987	bZIP transcription factor; Region: bZIP_1; cl02576
297246002988	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
297246002989	Protein of unknown function (DUF2895); Region: DUF2895; cl12968
297246002990	Protein of unknown function (DUF3487); Region: DUF3487; cl13432
297246002991	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
297246002992	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
297246002993	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
297246002994	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
297246002995	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
297246002996	Global regulator protein family; Region: CsrA; cl00670
297246002997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246002998	non-specific DNA binding site [nucleotide binding]; other site
297246002999	salt bridge; other site
297246003000	sequence-specific DNA binding site [nucleotide binding]; other site
297246003001	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
297246003002	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
297246003003	cofactor binding site; other site
297246003004	DNA binding site [nucleotide binding]
297246003005	substrate interaction site [chemical binding]; other site
297246003006	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
297246003007	additional DNA contacts [nucleotide binding]; other site
297246003008	mismatch recognition site; other site
297246003009	active site
297246003010	zinc binding site [ion binding]; other site
297246003011	DNA intercalation site [nucleotide binding]; other site
297246003012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003013	putative substrate translocation pore; other site
297246003014	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246003015	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
297246003016	active site
297246003017	catalytic residues [active]
297246003018	metal binding site [ion binding]; metal-binding site
297246003019	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
297246003020	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
297246003021	integrase; Provisional; Region: PRK09692
297246003022	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
297246003023	active site
297246003024	Int/Topo IB signature motif; other site
297246003025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246003026	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246003027	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
297246003028	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
297246003029	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
297246003030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246003031	S-adenosylmethionine binding site [chemical binding]; other site
297246003032	Fic family protein [Function unknown]; Region: COG3177
297246003033	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
297246003034	Fic/DOC family; Region: Fic; cl00960
297246003035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246003036	Coenzyme A binding pocket [chemical binding]; other site
297246003037	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
297246003038	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246003039	motif II; other site
297246003040	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
297246003041	Similar to transposase (IS5 family);hypothetical protein
297246003042	Similar to transposase (IS5 family);hypothetical protein
297246003043	hypothetical protein
297246003044	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246003045	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246003046	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246003047	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246003048	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246003049	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246003050	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246003051	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246003052	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246003053	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
297246003054	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
297246003055	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
297246003056	EamA-like transporter family; Region: EamA; cl01037
297246003057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246003058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246003059	PAS domain; Region: PAS_9; pfam13426
297246003060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246003061	PAS domain; Region: PAS_9; pfam13426
297246003062	putative active site [active]
297246003063	heme pocket [chemical binding]; other site
297246003064	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246003065	metal binding site [ion binding]; metal-binding site
297246003066	active site
297246003067	I-site; other site
297246003068	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246003069	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
297246003070	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
297246003071	tetramer interface [polypeptide binding]; other site
297246003072	dimer interface [polypeptide binding]; other site
297246003073	circadian clock protein KaiC; Reviewed; Region: PRK09302
297246003074	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003075	Walker A motif; other site
297246003076	ATP binding site [chemical binding]; other site
297246003077	Walker B motif; other site
297246003078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003079	Walker A motif; other site
297246003080	ATP binding site [chemical binding]; other site
297246003081	Walker B motif; other site
297246003082	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
297246003083	active site
297246003084	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246003085	Coenzyme A binding pocket [chemical binding]; other site
297246003086	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246003087	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
297246003088	catalytic core [active]
297246003089	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
297246003090	N-acetyl-D-glucosamine binding site [chemical binding]; other site
297246003091	catalytic residue [active]
297246003092	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246003093	putative peptidoglycan binding site; other site
297246003094	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
297246003095	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
297246003096	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246003097	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246003098	substrate binding pocket [chemical binding]; other site
297246003099	membrane-bound complex binding site; other site
297246003100	hinge residues; other site
297246003101	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246003102	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246003103	substrate binding pocket [chemical binding]; other site
297246003104	membrane-bound complex binding site; other site
297246003105	hinge residues; other site
297246003106	plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517
297246003107	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
297246003108	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246003109	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
297246003110	AMP-binding enzyme; Region: AMP-binding; cl15778
297246003111	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246003112	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
297246003113	nucleoside/Zn binding site; other site
297246003114	dimer interface [polypeptide binding]; other site
297246003115	catalytic motif [active]
297246003116	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
297246003117	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
297246003118	dimerization interface [polypeptide binding]; other site
297246003119	cyclase homology domain; Region: CHD; cd07302
297246003120	nucleotidyl binding site; other site
297246003121	metal binding site [ion binding]; metal-binding site
297246003122	dimer interface [polypeptide binding]; other site
297246003123	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
297246003124	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246003126	S-adenosylmethionine binding site [chemical binding]; other site
297246003127	Nitronate monooxygenase; Region: NMO; pfam03060
297246003128	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
297246003129	FMN binding site [chemical binding]; other site
297246003130	substrate binding site [chemical binding]; other site
297246003131	putative catalytic residue [active]
297246003132	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
297246003133	Helix-turn-helix domains; Region: HTH; cl00088
297246003134	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
297246003135	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
297246003136	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246003137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
297246003138	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
297246003139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246003140	dimer interface [polypeptide binding]; other site
297246003141	conserved gate region; other site
297246003142	putative PBP binding loops; other site
297246003143	ABC-ATPase subunit interface; other site
297246003144	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
297246003145	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
297246003146	Walker A/P-loop; other site
297246003147	ATP binding site [chemical binding]; other site
297246003148	Q-loop/lid; other site
297246003149	ABC transporter signature motif; other site
297246003150	Walker B; other site
297246003151	D-loop; other site
297246003152	H-loop/switch region; other site
297246003153	TOBE domain; Region: TOBE_2; cl01440
297246003154	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246003155	GIY-YIG motif/motif A; other site
297246003156	putative active site [active]
297246003157	putative metal binding site [ion binding]; other site
297246003158	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
297246003159	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
297246003160	NADP binding site [chemical binding]; other site
297246003161	active site
297246003162	steroid binding site; other site
297246003163	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
297246003164	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
297246003165	active site
297246003166	Zn binding site [ion binding]; other site
297246003167	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246003168	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
297246003169	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
297246003170	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
297246003171	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
297246003172	DNA binding site [nucleotide binding]
297246003173	active site
297246003174	probable polyamine oxidase; Region: PLN02268
297246003175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003176	pyruvate decarboxylase; Region: PLN02573
297246003177	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
297246003178	dimer interface [polypeptide binding]; other site
297246003179	PYR/PP interface [polypeptide binding]; other site
297246003180	TPP binding site [chemical binding]; other site
297246003181	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
297246003182	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
297246003183	TPP-binding site [chemical binding]; other site
297246003184	dimer interface [polypeptide binding]; other site
297246003185	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
297246003186	metal binding site [ion binding]; metal-binding site
297246003187	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246003188	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246003189	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246003190	active site
297246003191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003192	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246003193	putative substrate translocation pore; other site
297246003194	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
297246003195	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
297246003196	metal binding site [ion binding]; metal-binding site
297246003197	putative dimer interface [polypeptide binding]; other site
297246003198	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003199	Protein of unknown function (DUF520); Region: DUF520; cl00723
297246003200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246003201	metal binding site [ion binding]; metal-binding site
297246003202	active site
297246003203	I-site; other site
297246003204	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246003205	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
297246003206	putative ligand binding pocket/active site [active]
297246003207	putative metal binding site [ion binding]; other site
297246003208	AMMECR1; Region: AMMECR1; cl00911
297246003209	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
297246003210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246003211	FeS/SAM binding site; other site
297246003212	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246003213	Sel1 repeat; Region: Sel1; cl02723
297246003214	Sel1 repeat; Region: Sel1; cl02723
297246003215	Sel1 repeat; Region: Sel1; cl02723
297246003216	Sel1 repeat; Region: Sel1; cl02723
297246003217	Sel1 repeat; Region: Sel1; cl02723
297246003218	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246003219	Sel1 repeat; Region: Sel1; cl02723
297246003220	Sel1 repeat; Region: Sel1; cl02723
297246003221	Sel1 repeat; Region: Sel1; cl02723
297246003222	Sel1 repeat; Region: Sel1; cl02723
297246003223	Sel1 repeat; Region: Sel1; cl02723
297246003224	Sel1 repeat; Region: Sel1; cl02723
297246003225	Sel1 repeat; Region: Sel1; cl02723
297246003226	sensory histidine kinase AtoS; Provisional; Region: PRK11360
297246003227	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246003228	dimer interface [polypeptide binding]; other site
297246003229	phosphorylation site [posttranslational modification]
297246003230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246003231	ATP binding site [chemical binding]; other site
297246003232	Mg2+ binding site [ion binding]; other site
297246003233	G-X-G motif; other site
297246003234	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
297246003235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246003236	active site
297246003237	phosphorylation site [posttranslational modification]
297246003238	intermolecular recognition site; other site
297246003239	dimerization interface [polypeptide binding]; other site
297246003240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246003241	Walker A motif; other site
297246003242	ATP binding site [chemical binding]; other site
297246003243	Walker B motif; other site
297246003244	arginine finger; other site
297246003245	Helix-turn-helix domains; Region: HTH; cl00088
297246003246	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246003247	Peptidase family M48; Region: Peptidase_M48; cl12018
297246003248	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
297246003249	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
297246003250	catalytic motif [active]
297246003251	Zn binding site [ion binding]; other site
297246003252	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
297246003253	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
297246003254	Lumazine binding domain; Region: Lum_binding; pfam00677
297246003255	Lumazine binding domain; Region: Lum_binding; pfam00677
297246003256	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
297246003257	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
297246003258	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
297246003259	dimerization interface [polypeptide binding]; other site
297246003260	active site
297246003261	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
297246003262	homopentamer interface [polypeptide binding]; other site
297246003263	active site
297246003264	CTP synthetase; Validated; Region: pyrG; PRK05380
297246003265	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
297246003266	Catalytic site [active]
297246003267	active site
297246003268	UTP binding site [chemical binding]; other site
297246003269	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
297246003270	active site
297246003271	putative oxyanion hole; other site
297246003272	catalytic triad [active]
297246003273	NeuB family; Region: NeuB; cl00496
297246003274	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
297246003275	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246003276	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
297246003277	Putative exonuclease, RdgC; Region: RdgC; cl01122
297246003278	K+ potassium transporter; Region: K_trans; cl15781
297246003279	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
297246003280	PUA domain; Region: PUA; cl00607
297246003281	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
297246003282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246003283	S-adenosylmethionine binding site [chemical binding]; other site
297246003284	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
297246003285	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
297246003286	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
297246003287	conserved cys residue [active]
297246003288	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
297246003289	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
297246003290	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
297246003291	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
297246003292	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
297246003293	substrate binding site [chemical binding]; other site
297246003294	glutamase interaction surface [polypeptide binding]; other site
297246003295	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
297246003296	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
297246003297	catalytic residues [active]
297246003298	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
297246003299	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
297246003300	putative active site [active]
297246003301	oxyanion strand; other site
297246003302	catalytic triad [active]
297246003303	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
297246003304	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246003305	active site
297246003306	motif I; other site
297246003307	motif II; other site
297246003308	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
297246003309	putative active site pocket [active]
297246003310	4-fold oligomerization interface [polypeptide binding]; other site
297246003311	metal binding residues [ion binding]; metal-binding site
297246003312	3-fold/trimer interface [polypeptide binding]; other site
297246003313	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
297246003314	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
297246003315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246003316	homodimer interface [polypeptide binding]; other site
297246003317	catalytic residue [active]
297246003318	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
297246003319	histidinol dehydrogenase; Region: hisD; TIGR00069
297246003320	NAD binding site [chemical binding]; other site
297246003321	dimerization interface [polypeptide binding]; other site
297246003322	product binding site; other site
297246003323	substrate binding site [chemical binding]; other site
297246003324	zinc binding site [ion binding]; other site
297246003325	catalytic residues [active]
297246003326	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
297246003327	ATP phosphoribosyltransferase; Region: HisG; cl15266
297246003328	HisG, C-terminal domain; Region: HisG_C; cl06867
297246003329	Helix-turn-helix domains; Region: HTH; cl00088
297246003330	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
297246003331	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
297246003332	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
297246003333	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
297246003334	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
297246003335	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246003336	active site
297246003337	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246003338	DNA-binding site [nucleotide binding]; DNA binding site
297246003339	RNA-binding motif; other site
297246003340	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
297246003341	30S subunit binding site; other site
297246003342	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
297246003343	putative deacylase active site [active]
297246003344	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
297246003345	Helix-turn-helix domains; Region: HTH; cl00088
297246003346	Helix-turn-helix domains; Region: HTH; cl00088
297246003347	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
297246003348	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
297246003349	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246003350	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246003351	LysE type translocator; Region: LysE; cl00565
297246003352	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
297246003353	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246003354	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003355	AAA domain; Region: AAA_28; pfam13521
297246003356	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
297246003357	HupE / UreJ protein; Region: HupE_UreJ; cl01011
297246003358	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
297246003359	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
297246003360	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
297246003361	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
297246003362	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
297246003363	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
297246003364	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
297246003365	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
297246003366	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
297246003367	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628
297246003368	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
297246003369	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
297246003370	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
297246003371	FlgD Ig-like domain; Region: FlgD_ig; cl15790
297246003372	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
297246003373	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
297246003374	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
297246003375	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
297246003376	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
297246003377	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
297246003378	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
297246003379	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
297246003380	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
297246003381	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
297246003382	Flagellar L-ring protein; Region: FlgH; cl00905
297246003383	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
297246003384	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
297246003385	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
297246003386	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710
297246003387	Rod binding protein; Region: Rod-binding; cl01626
297246003388	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
297246003389	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715
297246003390	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
297246003391	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
297246003392	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
297246003393	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
297246003394	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
297246003395	active site
297246003396	nucleophile elbow; other site
297246003397	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
297246003398	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
297246003399	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
297246003400	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
297246003401	transmembrane helices; other site
297246003402	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
297246003403	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
297246003404	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
297246003405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003406	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
297246003407	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
297246003408	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
297246003409	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246003410	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246003411	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003412	Walker A/P-loop; other site
297246003413	ATP binding site [chemical binding]; other site
297246003414	Q-loop/lid; other site
297246003415	ABC transporter signature motif; other site
297246003416	Walker B; other site
297246003417	D-loop; other site
297246003418	H-loop/switch region; other site
297246003419	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
297246003420	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325
297246003421	malate dehydrogenase; Provisional; Region: PRK13529
297246003422	Malic enzyme, N-terminal domain; Region: malic; pfam00390
297246003423	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
297246003424	NAD(P) binding site [chemical binding]; other site
297246003425	Survival protein SurE; Region: SurE; cl00448
297246003426	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246003427	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
297246003428	putative peptidoglycan binding site; other site
297246003429	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
297246003430	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
297246003431	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
297246003432	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
297246003433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
297246003434	DNA binding residues [nucleotide binding]
297246003435	Cupin domain; Region: Cupin_2; cl09118
297246003436	Transcriptional regulator; Region: Transcrip_reg; cl00361
297246003437	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
297246003438	active site
297246003439	putative DNA-binding cleft [nucleotide binding]; other site
297246003440	dimer interface [polypeptide binding]; other site
297246003441	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
297246003442	RuvA N terminal domain; Region: RuvA_N; pfam01330
297246003443	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
297246003444	sensor protein QseC; Provisional; Region: PRK10337
297246003445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246003446	dimer interface [polypeptide binding]; other site
297246003447	phosphorylation site [posttranslational modification]
297246003448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246003449	ATP binding site [chemical binding]; other site
297246003450	Mg2+ binding site [ion binding]; other site
297246003451	G-X-G motif; other site
297246003452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246003453	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
297246003454	active site
297246003455	phosphorylation site [posttranslational modification]
297246003456	intermolecular recognition site; other site
297246003457	dimerization interface [polypeptide binding]; other site
297246003458	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
297246003459	DNA binding site [nucleotide binding]
297246003460	Intracellular septation protein A; Region: IspA; cl01098
297246003461	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
297246003462	N-acetyl-D-glucosamine binding site [chemical binding]; other site
297246003463	catalytic residue [active]
297246003464	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246003465	putative peptidoglycan binding site; other site
297246003466	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
297246003467	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246003468	putative peptidoglycan binding site; other site
297246003469	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246003470	putative peptidoglycan binding site; other site
297246003471	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
297246003472	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246003473	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
297246003474	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
297246003475	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
297246003476	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
297246003477	homodimer interface [polypeptide binding]; other site
297246003478	NADP binding site [chemical binding]; other site
297246003479	substrate binding site [chemical binding]; other site
297246003480	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
297246003481	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
297246003482	ribonuclease E; Reviewed; Region: rne; PRK10811
297246003483	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
297246003484	Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335
297246003485	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
297246003486	NADH(P)-binding; Region: NAD_binding_10; pfam13460
297246003487	putative NAD(P) binding site [chemical binding]; other site
297246003488	active site
297246003489	DoxX-like family; Region: DoxX_3; pfam13781
297246003490	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
297246003491	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
297246003492	dimerization interface 3.5A [polypeptide binding]; other site
297246003493	active site
297246003494	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
297246003495	active site
297246003496	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
297246003497	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
297246003498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246003499	catalytic residue [active]
297246003500	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
297246003501	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
297246003502	substrate binding site [chemical binding]; other site
297246003503	active site
297246003504	catalytic residues [active]
297246003505	heterodimer interface [polypeptide binding]; other site
297246003506	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
297246003507	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246003508	active site
297246003509	HIGH motif; other site
297246003510	nucleotide binding site [chemical binding]; other site
297246003511	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
297246003512	KMSKS motif; other site
297246003513	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
297246003514	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
297246003515	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
297246003516	active site
297246003517	HIGH motif; other site
297246003518	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
297246003519	KMSKS motif; other site
297246003520	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
297246003521	tRNA binding surface [nucleotide binding]; other site
297246003522	anticodon binding site; other site
297246003523	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
297246003524	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
297246003525	Sulfatase; Region: Sulfatase; cl10460
297246003526	general secretory pathway protein E; Region: type_II_gspE; TIGR02533
297246003527	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
297246003528	Walker A motif; other site
297246003529	ATP binding site [chemical binding]; other site
297246003530	Walker B motif; other site
297246003531	Sporulation related domain; Region: SPOR; cl10051
297246003532	general secretion pathway protein D; Region: type_II_gspD; TIGR02517
297246003533	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
297246003534	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
297246003535	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
297246003536	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
297246003537	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
297246003538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003539	Cache domain; Region: Cache_1; pfam02743
297246003540	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
297246003541	cyclase homology domain; Region: CHD; cd07302
297246003542	nucleotidyl binding site; other site
297246003543	metal binding site [ion binding]; metal-binding site
297246003544	dimer interface [polypeptide binding]; other site
297246003545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003546	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
297246003547	putative substrate translocation pore; other site
297246003548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003549	putative substrate translocation pore; other site
297246003550	IucA / IucC family; Region: IucA_IucC; pfam04183
297246003551	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
297246003552	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
297246003553	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
297246003554	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
297246003555	Sporulation related domain; Region: SPOR; cl10051
297246003556	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246003557	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
297246003558	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
297246003559	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
297246003560	protein binding site [polypeptide binding]; other site
297246003561	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
297246003562	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
297246003563	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
297246003564	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
297246003565	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
297246003566	RNA binding surface [nucleotide binding]; other site
297246003567	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
297246003568	active site
297246003569	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
297246003570	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
297246003571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246003572	FeS/SAM binding site; other site
297246003573	TRAM domain; Region: TRAM; cl01282
297246003574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003575	putative substrate translocation pore; other site
297246003576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246003577	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246003578	Flagellar protein FliS; Region: FliS; cl00654
297246003579	flagellar capping protein; Provisional; Region: PRK12765
297246003580	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
297246003581	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
297246003582	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
297246003583	flagellin; Provisional; Region: PRK12806
297246003584	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
297246003585	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
297246003586	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
297246003587	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246003588	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
297246003589	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246003590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
297246003591	Sporulation related domain; Region: SPOR; cl10051
297246003592	Colicin V production protein; Region: Colicin_V; cl00567
297246003593	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
297246003594	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
297246003595	active site
297246003596	(T/H)XGH motif; other site
297246003597	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
297246003598	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
297246003599	Lipopolysaccharide-assembly; Region: LptE; cl01125
297246003600	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
297246003601	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
297246003602	HIGH motif; other site
297246003603	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
297246003604	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246003605	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246003606	active site
297246003607	KMSKS motif; other site
297246003608	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
297246003609	tRNA binding surface [nucleotide binding]; other site
297246003610	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
297246003611	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
297246003612	putative active site [active]
297246003613	catalytic triad [active]
297246003614	putative dimer interface [polypeptide binding]; other site
297246003615	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
297246003616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003617	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246003618	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
297246003619	tetrameric interface [polypeptide binding]; other site
297246003620	NAD binding site [chemical binding]; other site
297246003621	catalytic residues [active]
297246003622	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
297246003623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003624	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
297246003625	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
297246003626	substrate binding site [chemical binding]; other site
297246003627	oxyanion hole (OAH) forming residues; other site
297246003628	trimer interface [polypeptide binding]; other site
297246003629	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
297246003630	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
297246003631	dimer interface [polypeptide binding]; other site
297246003632	active site
297246003633	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
297246003634	oxyanion hole [active]
297246003635	Sel1 repeat; Region: Sel1; cl02723
297246003636	Sel1 repeat; Region: Sel1; cl02723
297246003637	Sel1 repeat; Region: Sel1; cl02723
297246003638	Sel1 repeat; Region: Sel1; cl02723
297246003639	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246003640	Sel1 repeat; Region: Sel1; cl02723
297246003641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246003642	PAS domain; Region: PAS_9; pfam13426
297246003643	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246003644	metal binding site [ion binding]; metal-binding site
297246003645	active site
297246003646	I-site; other site
297246003647	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246003648	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
297246003649	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246003650	general secretion pathway protein J; Region: gspJ; TIGR01711
297246003651	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
297246003652	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
297246003653	Type II transport protein GspH; Region: GspH; pfam12019
297246003654	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
297246003655	general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710
297246003656	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
297246003657	general secretion pathway protein F; Region: GspF; TIGR02120
297246003658	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
297246003659	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
297246003660	glutamine synthetase; Provisional; Region: glnA; PRK09469
297246003661	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
297246003662	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
297246003663	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
297246003664	Protein of unknown function (DUF328); Region: DUF328; cl01143
297246003665	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
297246003666	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
297246003667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246003668	catalytic residue [active]
297246003669	heat shock protein 90; Provisional; Region: PRK05218
297246003670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
297246003671	Helix-turn-helix domains; Region: HTH; cl00088
297246003672	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
297246003673	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
297246003674	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
297246003675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246003676	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
297246003677	RNA/DNA hybrid binding site [nucleotide binding]; other site
297246003678	active site
297246003679	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
297246003680	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
297246003681	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
297246003682	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246003683	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
297246003684	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
297246003685	Oligomerisation domain; Region: Oligomerisation; cl00519
297246003686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246003687	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
297246003688	urocanate hydratase; Provisional; Region: PRK05414
297246003689	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
297246003690	active sites [active]
297246003691	tetramer interface [polypeptide binding]; other site
297246003692	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
297246003693	NAD(P) binding site [chemical binding]; other site
297246003694	catalytic residues [active]
297246003695	short chain dehydrogenase; Provisional; Region: PRK08278
297246003696	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
297246003697	NAD(P) binding site [chemical binding]; other site
297246003698	homodimer interface [polypeptide binding]; other site
297246003699	active site
297246003700	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
297246003701	RNA/DNA hybrid binding site [nucleotide binding]; other site
297246003702	active site
297246003703	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
297246003704	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
297246003705	active site
297246003706	substrate binding site [chemical binding]; other site
297246003707	catalytic site [active]
297246003708	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246003709	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
297246003710	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
297246003711	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
297246003712	Ligand Binding Site [chemical binding]; other site
297246003713	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
297246003714	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
297246003715	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
297246003716	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
297246003717	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
297246003718	dimer interface [polypeptide binding]; other site
297246003719	active site
297246003720	CoA binding pocket [chemical binding]; other site
297246003721	Acyl transferase domain; Region: Acyl_transf_1; cl08282
297246003722	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
297246003723	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
297246003724	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
297246003725	NAD(P) binding site [chemical binding]; other site
297246003726	homotetramer interface [polypeptide binding]; other site
297246003727	homodimer interface [polypeptide binding]; other site
297246003728	active site
297246003729	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246003730	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
297246003731	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
297246003732	dimer interface [polypeptide binding]; other site
297246003733	active site
297246003734	YceG-like family; Region: YceG; pfam02618
297246003735	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
297246003736	dimerization interface [polypeptide binding]; other site
297246003737	thymidylate kinase; Validated; Region: tmk; PRK00698
297246003738	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
297246003739	TMP-binding site; other site
297246003740	ATP-binding site [chemical binding]; other site
297246003741	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
297246003742	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003743	PilZ domain; Region: PilZ; cl01260
297246003744	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
297246003745	active site
297246003746	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
297246003747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003748	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246003749	putative substrate translocation pore; other site
297246003750	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
297246003751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003752	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
297246003753	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
297246003754	Ligand binding site; other site
297246003755	Putative Catalytic site; other site
297246003756	DXD motif; other site
297246003757	GtrA-like protein; Region: GtrA; cl00971
297246003758	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
297246003759	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
297246003760	active site
297246003761	ATP binding site [chemical binding]; other site
297246003762	substrate binding site [chemical binding]; other site
297246003763	dimer interface [polypeptide binding]; other site
297246003764	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
297246003765	active site
297246003766	catalytic site [active]
297246003767	substrate binding site [chemical binding]; other site
297246003768	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
297246003769	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
297246003770	N-acetyl-D-glucosamine binding site [chemical binding]; other site
297246003771	catalytic residue [active]
297246003772	adenylate kinase; Reviewed; Region: adk; PRK00279
297246003773	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
297246003774	AMP-binding site [chemical binding]; other site
297246003775	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
297246003776	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
297246003777	catalytic residues [active]
297246003778	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
297246003779	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
297246003780	glycerol kinase; Region: glycerol_kin; TIGR01311
297246003781	N- and C-terminal domain interface [polypeptide binding]; other site
297246003782	active site
297246003783	MgATP binding site [chemical binding]; other site
297246003784	catalytic site [active]
297246003785	metal binding site [ion binding]; metal-binding site
297246003786	glycerol binding site [chemical binding]; other site
297246003787	homotetramer interface [polypeptide binding]; other site
297246003788	homodimer interface [polypeptide binding]; other site
297246003789	FBP binding site [chemical binding]; other site
297246003790	protein IIAGlc interface [polypeptide binding]; other site
297246003791	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
297246003792	dimer interface [polypeptide binding]; other site
297246003793	Citrate synthase; Region: Citrate_synt; pfam00285
297246003794	active site
297246003795	citrylCoA binding site [chemical binding]; other site
297246003796	NADH binding [chemical binding]; other site
297246003797	cationic pore residues; other site
297246003798	oxalacetate/citrate binding site [chemical binding]; other site
297246003799	coenzyme A binding site [chemical binding]; other site
297246003800	catalytic triad [active]
297246003801	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
297246003802	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
297246003803	DNA gyrase subunit A; Validated; Region: PRK05560
297246003804	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
297246003805	CAP-like domain; other site
297246003806	active site
297246003807	primary dimer interface [polypeptide binding]; other site
297246003808	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003809	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003810	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003811	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003812	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003813	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
297246003814	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
297246003815	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
297246003816	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246003817	catalytic residue [active]
297246003818	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
297246003819	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
297246003820	hinge; other site
297246003821	active site
297246003822	cytidylate kinase; Provisional; Region: cmk; PRK00023
297246003823	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
297246003824	CMP-binding site; other site
297246003825	The sites determining sugar specificity; other site
297246003826	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
297246003827	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
297246003828	RNA binding site [nucleotide binding]; other site
297246003829	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
297246003830	RNA binding site [nucleotide binding]; other site
297246003831	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
297246003832	RNA binding site [nucleotide binding]; other site
297246003833	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
297246003834	RNA binding site [nucleotide binding]; other site
297246003835	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
297246003836	RNA binding site [nucleotide binding]; other site
297246003837	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
297246003838	RNA binding site [nucleotide binding]; other site
297246003839	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
297246003840	tetratricopeptide repeat protein; Provisional; Region: PRK11788
297246003841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246003842	TPR motif; other site
297246003843	binding surface
297246003844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246003845	binding surface
297246003846	TPR motif; other site
297246003847	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
297246003848	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
297246003849	inhibitor-cofactor binding pocket; inhibition site
297246003850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246003851	catalytic residue [active]
297246003852	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
297246003853	active site
297246003854	dimer interface [polypeptide binding]; other site
297246003855	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
297246003856	active site
297246003857	nucleophile elbow; other site
297246003858	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
297246003859	classical (c) SDRs; Region: SDR_c; cd05233
297246003860	NAD(P) binding site [chemical binding]; other site
297246003861	active site
297246003862	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
297246003863	UTRA domain; Region: UTRA; cl01230
297246003864	UbiA prenyltransferase family; Region: UbiA; cl00337
297246003865	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
297246003866	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
297246003867	FAD binding domain; Region: FAD_binding_4; pfam01565
297246003868	Berberine and berberine like; Region: BBE; pfam08031
297246003869	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
297246003870	catalytic residue [active]
297246003871	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
297246003872	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
297246003873	active site
297246003874	catalytic motif [active]
297246003875	Zn binding site [ion binding]; other site
297246003876	two-component sensor protein; Provisional; Region: cpxA; PRK09470
297246003877	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
297246003878	dimerization interface [polypeptide binding]; other site
297246003879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246003880	dimer interface [polypeptide binding]; other site
297246003881	phosphorylation site [posttranslational modification]
297246003882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246003883	ATP binding site [chemical binding]; other site
297246003884	Mg2+ binding site [ion binding]; other site
297246003885	G-X-G motif; other site
297246003886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
297246003887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246003888	active site
297246003889	phosphorylation site [posttranslational modification]
297246003890	intermolecular recognition site; other site
297246003891	dimerization interface [polypeptide binding]; other site
297246003892	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
297246003893	DNA binding site [nucleotide binding]
297246003894	FOG: CBS domain [General function prediction only]; Region: COG0517
297246003895	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
297246003896	Transporter associated domain; Region: CorC_HlyC; cl08393
297246003897	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
297246003898	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
297246003899	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003900	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
297246003901	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
297246003902	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
297246003903	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
297246003904	active site
297246003905	HIGH motif; other site
297246003906	dimer interface [polypeptide binding]; other site
297246003907	KMSKS motif; other site
297246003908	ScpA/B protein; Region: ScpA_ScpB; cl00598
297246003909	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
297246003910	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
297246003911	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
297246003912	RNA binding surface [nucleotide binding]; other site
297246003913	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
297246003914	probable active site [active]
297246003915	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
297246003916	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246003917	DNA binding residues [nucleotide binding]
297246003918	dimerization interface [polypeptide binding]; other site
297246003919	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
297246003920	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
297246003921	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
297246003922	oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN02750
297246003923	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246003924	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
297246003925	substrate binding site [chemical binding]; other site
297246003926	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246003927	putative transporter; Provisional; Region: PRK10504
297246003928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246003929	putative substrate translocation pore; other site
297246003930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246003931	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
297246003932	TRAM domain; Region: TRAM; cl01282
297246003933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246003934	S-adenosylmethionine binding site [chemical binding]; other site
297246003935	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
297246003936	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246003937	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
297246003938	synthetase active site [active]
297246003939	NTP binding site [chemical binding]; other site
297246003940	metal binding site [ion binding]; metal-binding site
297246003941	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
297246003942	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
297246003943	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
297246003944	aminotransferase; Validated; Region: PRK08175
297246003945	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
297246003946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246003947	homodimer interface [polypeptide binding]; other site
297246003948	catalytic residue [active]
297246003949	Sulfatase; Region: Sulfatase; cl10460
297246003950	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
297246003951	DHH family; Region: DHH; pfam01368
297246003952	DHHA1 domain; Region: DHHA1; pfam02272
297246003953	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
297246003954	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
297246003955	FMN binding site [chemical binding]; other site
297246003956	active site
297246003957	catalytic residues [active]
297246003958	substrate binding site [chemical binding]; other site
297246003959	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104
297246003960	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003961	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
297246003962	SEC-C motif; Region: SEC-C; pfam02810
297246003963	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
297246003964	active site
297246003965	8-oxo-dGMP binding site [chemical binding]; other site
297246003966	nudix motif; other site
297246003967	metal binding site [ion binding]; metal-binding site
297246003968	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
297246003969	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
297246003970	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
297246003971	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
297246003972	CoA-binding site [chemical binding]; other site
297246003973	ATP-binding [chemical binding]; other site
297246003974	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246003975	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
297246003976	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246003977	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
297246003978	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
297246003979	inhibitor-cofactor binding pocket; inhibition site
297246003980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246003981	catalytic residue [active]
297246003982	biotin synthase; Region: bioB; TIGR00433
297246003983	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246003984	FeS/SAM binding site; other site
297246003985	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
297246003986	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
297246003987	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
297246003988	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246003989	catalytic residue [active]
297246003990	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
297246003991	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246003992	AAA domain; Region: AAA_26; pfam13500
297246003993	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246003994	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
297246003995	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
297246003996	Protein of unknown function (DUF502); Region: DUF502; cl01107
297246003997	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
297246003998	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
297246003999	dimer interface [polypeptide binding]; other site
297246004000	anticodon binding site; other site
297246004001	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
297246004002	homodimer interface [polypeptide binding]; other site
297246004003	motif 1; other site
297246004004	active site
297246004005	motif 2; other site
297246004006	GAD domain; Region: GAD; pfam02938
297246004007	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
297246004008	motif 3; other site
297246004009	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
297246004010	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
297246004011	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
297246004012	Mechanosensitive ion channel; Region: MS_channel; pfam00924
297246004013	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
297246004014	putative DNA-binding cleft [nucleotide binding]; other site
297246004015	putative DNA clevage site; other site
297246004016	molecular lever; other site
297246004017	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
297246004018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
297246004019	active site
297246004020	ATP binding site [chemical binding]; other site
297246004021	substrate binding site [chemical binding]; other site
297246004022	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246004023	substrate binding site [chemical binding]; other site
297246004024	activation loop (A-loop); other site
297246004025	activation loop (A-loop); other site
297246004026	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
297246004027	Helix-turn-helix domains; Region: HTH; cl00088
297246004028	Predicted acetyltransferase [General function prediction only]; Region: COG3153
297246004029	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246004030	Coenzyme A binding pocket [chemical binding]; other site
297246004031	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
297246004032	GAF domain; Region: GAF; cl15785
297246004033	cyclase homology domain; Region: CHD; cd07302
297246004034	nucleotidyl binding site; other site
297246004035	metal binding site [ion binding]; metal-binding site
297246004036	dimer interface [polypeptide binding]; other site
297246004037	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246004038	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
297246004039	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
297246004040	putative active site pocket [active]
297246004041	dimerization interface [polypeptide binding]; other site
297246004042	putative catalytic residue [active]
297246004043	Dot/Icm substrate protein; Region: SidE; pfam12252
297246004044	aminopeptidase N; Provisional; Region: pepN; PRK14015
297246004045	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
297246004046	Zn binding site [ion binding]; other site
297246004047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004048	NAD(P) binding site [chemical binding]; other site
297246004049	active site
297246004050	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
297246004051	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246004052	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
297246004053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004054	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246004055	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
297246004056	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
297246004057	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
297246004058	E3 interaction surface; other site
297246004059	lipoyl attachment site [posttranslational modification]; other site
297246004060	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
297246004061	E3 interaction surface; other site
297246004062	lipoyl attachment site [posttranslational modification]; other site
297246004063	e3 binding domain; Region: E3_binding; pfam02817
297246004064	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
297246004065	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
297246004066	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
297246004067	dimer interface [polypeptide binding]; other site
297246004068	TPP-binding site [chemical binding]; other site
297246004069	CobD/Cbib protein; Region: CobD_Cbib; cl00561
297246004070	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
297246004071	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
297246004072	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
297246004073	Sporulation related domain; Region: SPOR; cl10051
297246004074	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
297246004075	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246004076	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
297246004077	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
297246004078	homodimer interface [polypeptide binding]; other site
297246004079	substrate-cofactor binding pocket; other site
297246004080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246004081	catalytic residue [active]
297246004082	Protein of unknown function (DUF493); Region: DUF493; cl01102
297246004083	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
297246004084	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
297246004085	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
297246004086	active site
297246004087	LssY C-terminus; Region: LssY_C; pfam14067
297246004088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
297246004089	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421
297246004090	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
297246004091	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246004092	ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
297246004093	Walker A/P-loop; other site
297246004094	ATP binding site [chemical binding]; other site
297246004095	Q-loop/lid; other site
297246004096	ABC transporter signature motif; other site
297246004097	Walker B; other site
297246004098	D-loop; other site
297246004099	H-loop/switch region; other site
297246004100	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
297246004101	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246004102	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246004103	PAS domain S-box; Region: sensory_box; TIGR00229
297246004104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246004105	metal binding site [ion binding]; metal-binding site
297246004106	active site
297246004107	I-site; other site
297246004108	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246004109	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246004110	active site
297246004111	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
297246004112	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
297246004113	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
297246004114	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
297246004115	Walker A motif; other site
297246004116	ATP binding site [chemical binding]; other site
297246004117	Walker B motif; other site
297246004118	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
297246004119	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
297246004120	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
297246004121	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
297246004122	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
297246004123	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
297246004124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246004125	ligand binding site [chemical binding]; other site
297246004126	CAAX protease self-immunity; Region: Abi; cl00558
297246004127	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
297246004128	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
297246004129	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
297246004130	dimer interface [polypeptide binding]; other site
297246004131	Citrate synthase; Region: Citrate_synt; pfam00285
297246004132	active site
297246004133	citrylCoA binding site [chemical binding]; other site
297246004134	oxalacetate/citrate binding site [chemical binding]; other site
297246004135	coenzyme A binding site [chemical binding]; other site
297246004136	catalytic triad [active]
297246004137	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
297246004138	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
297246004139	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
297246004140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246004141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246004143	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
297246004144	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
297246004145	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
297246004146	inhibitor-cofactor binding pocket; inhibition site
297246004147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246004148	catalytic residue [active]
297246004149	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
297246004150	Rubredoxin; Region: Rubredoxin; pfam00301
297246004151	iron binding site [ion binding]; other site
297246004152	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
297246004153	Integral membrane protein TerC family; Region: TerC; cl10468
297246004154	poly(A) polymerase; Region: pcnB; TIGR01942
297246004155	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
297246004156	active site
297246004157	NTP binding site [chemical binding]; other site
297246004158	metal binding triad [ion binding]; metal-binding site
297246004159	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
297246004160	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
297246004161	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
297246004162	catalytic center binding site [active]
297246004163	ATP binding site [chemical binding]; other site
297246004164	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
297246004165	Ligand Binding Site [chemical binding]; other site
297246004166	GTP-binding protein Der; Reviewed; Region: PRK00093
297246004167	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
297246004168	G1 box; other site
297246004169	GTP/Mg2+ binding site [chemical binding]; other site
297246004170	Switch I region; other site
297246004171	G2 box; other site
297246004172	Switch II region; other site
297246004173	G3 box; other site
297246004174	G4 box; other site
297246004175	G5 box; other site
297246004176	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
297246004177	G1 box; other site
297246004178	GTP/Mg2+ binding site [chemical binding]; other site
297246004179	Switch I region; other site
297246004180	G2 box; other site
297246004181	G3 box; other site
297246004182	Switch II region; other site
297246004183	G4 box; other site
297246004184	G5 box; other site
297246004185	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
297246004186	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
297246004187	Trp docking motif [polypeptide binding]; other site
297246004188	active site
297246004189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
297246004190	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
297246004191	histidyl-tRNA synthetase; Region: hisS; TIGR00442
297246004192	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
297246004193	dimer interface [polypeptide binding]; other site
297246004194	motif 1; other site
297246004195	active site
297246004196	motif 2; other site
297246004197	motif 3; other site
297246004198	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
297246004199	anticodon binding site; other site
297246004200	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
297246004201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
297246004202	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
297246004203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246004204	binding surface
297246004205	TPR motif; other site
297246004206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246004207	binding surface
297246004208	TPR motif; other site
297246004209	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
297246004210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246004211	FeS/SAM binding site; other site
297246004212	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
297246004213	active site
297246004214	multimer interface [polypeptide binding]; other site
297246004215	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
297246004216	active site
297246004217	dinuclear metal binding site [ion binding]; other site
297246004218	dimerization interface [polypeptide binding]; other site
297246004219	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
297246004220	putative active site [active]
297246004221	putative metal binding site [ion binding]; other site
297246004222	septum formation inhibitor; Reviewed; Region: minC; PRK00339
297246004223	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
297246004224	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
297246004225	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
297246004226	AMP-binding enzyme; Region: AMP-binding; cl15778
297246004227	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246004228	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
297246004229	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
297246004230	substrate binding pocket [chemical binding]; other site
297246004231	membrane-bound complex binding site; other site
297246004232	hinge residues; other site
297246004233	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
297246004234	putative active site [active]
297246004235	putative CoA binding site [chemical binding]; other site
297246004236	nudix motif; other site
297246004237	metal binding site [ion binding]; metal-binding site
297246004238	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
297246004239	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
297246004240	chorismate binding enzyme; Region: Chorismate_bind; cl10555
297246004241	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
297246004242	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
297246004243	TPP-binding site [chemical binding]; other site
297246004244	tetramer interface [polypeptide binding]; other site
297246004245	heterodimer interface [polypeptide binding]; other site
297246004246	phosphorylation loop region [posttranslational modification]
297246004247	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
297246004248	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
297246004249	alpha subunit interface [polypeptide binding]; other site
297246004250	TPP binding site [chemical binding]; other site
297246004251	heterodimer interface [polypeptide binding]; other site
297246004252	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
297246004253	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
297246004254	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
297246004255	E3 interaction surface; other site
297246004256	lipoyl attachment site [posttranslational modification]; other site
297246004257	e3 binding domain; Region: E3_binding; pfam02817
297246004258	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
297246004259	Mechanosensitive ion channel; Region: MS_channel; pfam00924
297246004260	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
297246004261	mercuric reductase; Validated; Region: PRK06370
297246004262	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246004263	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
297246004264	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434
297246004265	NMT1/THI5 like; Region: NMT1; pfam09084
297246004266	NMT1-like family; Region: NMT1_2; cl15260
297246004267	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004268	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
297246004269	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
297246004270	thiS-thiF/thiG interaction site; other site
297246004271	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
297246004272	ThiS interaction site; other site
297246004273	putative active site [active]
297246004274	tetramer interface [polypeptide binding]; other site
297246004275	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
297246004276	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
297246004277	dimer interface [polypeptide binding]; other site
297246004278	substrate binding site [chemical binding]; other site
297246004279	ATP binding site [chemical binding]; other site
297246004280	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
297246004281	thiamine phosphate binding site [chemical binding]; other site
297246004282	active site
297246004283	pyrophosphate binding site [ion binding]; other site
297246004284	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
297246004285	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
297246004286	ATP binding site [chemical binding]; other site
297246004287	substrate interface [chemical binding]; other site
297246004288	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
297246004289	active site residue [active]
297246004290	S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265
297246004291	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
297246004292	TolB amino-terminal domain; Region: TolB_N; cl00639
297246004293	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
297246004294	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
297246004295	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
297246004296	TolA protein; Region: tolA_full; TIGR02794
297246004297	Gram-negative bacterial tonB protein; Region: TonB; cl10048
297246004298	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
297246004299	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
297246004300	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
297246004301	active site
297246004302	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
297246004303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004304	Walker A motif; other site
297246004305	ATP binding site [chemical binding]; other site
297246004306	Walker B motif; other site
297246004307	arginine finger; other site
297246004308	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
297246004309	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
297246004310	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
297246004311	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
297246004312	DNA binding residues [nucleotide binding]
297246004313	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
297246004314	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
297246004315	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
297246004316	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
297246004317	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
297246004318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
297246004320	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246004321	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246004322	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
297246004323	NAD(P) binding site [chemical binding]; other site
297246004324	catalytic residues [active]
297246004325	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
297246004326	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
297246004327	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
297246004328	putative catalytic residue [active]
297246004329	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
297246004330	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
297246004331	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
297246004332	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
297246004333	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
297246004334	Global regulator protein family; Region: CsrA; cl00670
297246004335	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
297246004336	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246004337	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
297246004338	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
297246004339	substrate binding site [chemical binding]; other site
297246004340	oxyanion hole (OAH) forming residues; other site
297246004341	trimer interface [polypeptide binding]; other site
297246004342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004343	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
297246004344	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
297246004345	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
297246004346	dimer interface [polypeptide binding]; other site
297246004347	active site
297246004348	Helix-turn-helix domains; Region: HTH; cl00088
297246004349	Winged helix-turn helix; Region: HTH_29; pfam13551
297246004350	Helix-turn-helix domains; Region: HTH; cl00088
297246004351	Integrase core domain; Region: rve; cl01316
297246004352	hypothetical protein
297246004353	hypothetical protein
297246004354	similar to transposase;hypothetical protein
297246004355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
297246004356	Helix-turn-helix domains; Region: HTH; cl00088
297246004357	Integrase core domain; Region: rve; cl01316
297246004358	transposase/IS protein; Provisional; Region: PRK09183
297246004359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004360	Walker A motif; other site
297246004361	ATP binding site [chemical binding]; other site
297246004362	Walker B motif; other site
297246004363	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
297246004364	Helix-turn-helix domains; Region: HTH; cl00088
297246004365	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
297246004366	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246004367	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246004368	Leucine-rich repeats; other site
297246004369	Substrate binding site [chemical binding]; other site
297246004370	RES domain; Region: RES; cl02411
297246004371	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
297246004372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246004373	S-adenosylmethionine binding site [chemical binding]; other site
297246004374	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
297246004375	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
297246004376	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
297246004377	nudix motif; other site
297246004378	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
297246004379	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
297246004380	putative catalytic cysteine [active]
297246004381	gamma-glutamyl kinase; Provisional; Region: PRK05429
297246004382	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
297246004383	nucleotide binding site [chemical binding]; other site
297246004384	homotetrameric interface [polypeptide binding]; other site
297246004385	putative phosphate binding site [ion binding]; other site
297246004386	putative allosteric binding site; other site
297246004387	PUA domain; Region: PUA; cl00607
297246004388	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246004389	Coenzyme A binding pocket [chemical binding]; other site
297246004390	Phosphotransferase enzyme family; Region: APH; pfam01636
297246004391	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246004392	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
297246004393	putative active site [active]
297246004394	Similar to transposase (IS5 family);hypothetical protein
297246004395	Similar to transposase (IS5 family);hypothetical protein
297246004396	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
297246004397	DNA binding residues [nucleotide binding]
297246004398	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
297246004399	dimer interface [polypeptide binding]; other site
297246004400	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
297246004401	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
297246004402	active site
297246004403	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
297246004404	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
297246004405	DNA binding residues [nucleotide binding]
297246004406	dimer interface [polypeptide binding]; other site
297246004407	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
297246004408	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246004409	Coenzyme A binding pocket [chemical binding]; other site
297246004410	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
297246004411	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246004412	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246004413	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246004414	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246004415	Walker A/P-loop; other site
297246004416	ATP binding site [chemical binding]; other site
297246004417	Q-loop/lid; other site
297246004418	ABC transporter signature motif; other site
297246004419	Walker B; other site
297246004420	D-loop; other site
297246004421	H-loop/switch region; other site
297246004422	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
297246004423	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246004424	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
297246004425	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246004426	Cytochrome c; Region: Cytochrom_C; cl11414
297246004427	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246004428	BlaR1 peptidase M56; Region: Peptidase_M56; cl15829
297246004429	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246004430	Helix-turn-helix domains; Region: HTH; cl00088
297246004431	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
297246004432	PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575
297246004433	Permutation of conserved domain; other site
297246004434	active site
297246004435	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
297246004436	putative hydrolase; Provisional; Region: PRK10985
297246004437	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
297246004438	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246004439	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246004440	AMP-binding enzyme; Region: AMP-binding; cl15778
297246004441	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
297246004442	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246004443	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
297246004444	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004445	NAD(P) binding site [chemical binding]; other site
297246004446	active site
297246004447	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
297246004448	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
297246004449	dimer interface [polypeptide binding]; other site
297246004450	active site
297246004451	CoA binding pocket [chemical binding]; other site
297246004452	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
297246004453	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
297246004454	putative ADP-binding pocket [chemical binding]; other site
297246004455	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
297246004456	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
297246004457	FAD binding domain; Region: FAD_binding_4; pfam01565
297246004458	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
297246004459	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
297246004460	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
297246004461	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
297246004462	active site
297246004463	catalytic site [active]
297246004464	tetramer interface [polypeptide binding]; other site
297246004465	enterobactin exporter EntS; Provisional; Region: PRK10489
297246004466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246004467	putative substrate translocation pore; other site
297246004468	Predicted membrane protein [Function unknown]; Region: COG2119
297246004469	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
297246004470	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
297246004471	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
297246004472	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
297246004473	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
297246004474	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246004475	C-terminal part of L. pneumophila sidB protein;hypothetical protein
297246004476	Similar to N-terminal part of sidB protein;hypothetical protein
297246004477	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
297246004478	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
297246004479	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246004480	catalytic residue [active]
297246004481	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246004482	Dot/Icm substrate protein; Region: SidE; pfam12252
297246004483	YceI-like domain; Region: YceI; cl01001
297246004484	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
297246004485	YceI-like domain; Region: YceI; cl01001
297246004486	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
297246004487	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
297246004488	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
297246004489	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
297246004490	dimer interface [polypeptide binding]; other site
297246004491	PYR/PP interface [polypeptide binding]; other site
297246004492	TPP binding site [chemical binding]; other site
297246004493	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
297246004494	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
297246004495	TPP-binding site; other site
297246004496	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
297246004497	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
297246004498	substrate binding site [chemical binding]; other site
297246004499	ATP binding site [chemical binding]; other site
297246004500	KduI/IolB family; Region: KduI; cl01508
297246004501	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
297246004502	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004503	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
297246004504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246004505	putative substrate translocation pore; other site
297246004506	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
297246004507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246004508	Tetratricopeptide repeat; Region: TPR_12; pfam13424
297246004509	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
297246004510	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
297246004511	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
297246004512	active site
297246004513	Zn binding site [ion binding]; other site
297246004514	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246004515	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
297246004516	Amidinotransferase; Region: Amidinotransf; cl12043
297246004517	Amino acid permease; Region: AA_permease_2; pfam13520
297246004518	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246004519	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
297246004520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246004521	putative substrate translocation pore; other site
297246004522	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
297246004523	Transglycosylase; Region: Transgly; cl07896
297246004524	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246004525	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
297246004526	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
297246004527	MG2 domain; Region: A2M_N; pfam01835
297246004528	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
297246004529	Alpha-2-macroglobulin family; Region: A2M; pfam00207
297246004530	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
297246004531	surface patch; other site
297246004532	thioester region; other site
297246004533	specificity defining residues; other site
297246004534	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
297246004535	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
297246004536	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
297246004537	active site
297246004538	catalytic site [active]
297246004539	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
297246004540	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
297246004541	active site
297246004542	substrate binding site [chemical binding]; other site
297246004543	cosubstrate binding site; other site
297246004544	catalytic site [active]
297246004545	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
297246004546	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
297246004547	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246004548	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
297246004549	amidophosphoribosyltransferase; Provisional; Region: PRK09246
297246004550	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
297246004551	active site
297246004552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246004553	active site
297246004554	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
297246004555	ATP binding site [chemical binding]; other site
297246004556	active site
297246004557	substrate binding site [chemical binding]; other site
297246004558	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
297246004559	putative active site [active]
297246004560	catalytic triad [active]
297246004561	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
297246004562	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
297246004563	dimerization interface [polypeptide binding]; other site
297246004564	putative ATP binding site [chemical binding]; other site
297246004565	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
297246004566	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
297246004567	dimerization interface [polypeptide binding]; other site
297246004568	ATP binding site [chemical binding]; other site
297246004569	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
297246004570	dimerization interface [polypeptide binding]; other site
297246004571	ATP binding site [chemical binding]; other site
297246004572	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
297246004573	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
297246004574	DsbD alpha interface [polypeptide binding]; other site
297246004575	catalytic residues [active]
297246004576	short chain dehydrogenase; Validated; Region: PRK06182
297246004577	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
297246004578	NADP binding site [chemical binding]; other site
297246004579	active site
297246004580	steroid binding site; other site
297246004581	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
297246004582	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
297246004583	aconitate hydratase; Validated; Region: PRK09277
297246004584	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
297246004585	substrate binding site [chemical binding]; other site
297246004586	ligand binding site [chemical binding]; other site
297246004587	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
297246004588	substrate binding site [chemical binding]; other site
297246004589	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
297246004590	Spore germination protein; Region: Spore_permease; cl15802
297246004591	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
297246004592	Proline dehydrogenase; Region: Pro_dh; cl03282
297246004593	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
297246004594	Glutamate binding site [chemical binding]; other site
297246004595	NAD binding site [chemical binding]; other site
297246004596	catalytic residues [active]
297246004597	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
297246004598	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
297246004599	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
297246004600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246004601	S-adenosylmethionine binding site [chemical binding]; other site
297246004602	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
297246004603	ligand binding site [chemical binding]; other site
297246004604	active site
297246004605	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
297246004606	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
297246004607	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
297246004608	active site
297246004609	DNA binding site [nucleotide binding]
297246004610	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
297246004611	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
297246004612	Catalytic site [active]
297246004613	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
297246004614	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
297246004615	metal binding site [ion binding]; metal-binding site
297246004616	dimer interface [polypeptide binding]; other site
297246004617	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
297246004618	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246004619	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
297246004620	NAD(P) binding site [chemical binding]; other site
297246004621	catalytic residues [active]
297246004622	Succinylarginine dihydrolase; Region: AstB; cl01511
297246004623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246004624	Cytochrome c; Region: Cytochrom_C; cl11414
297246004625	ribosome recycling factor; Reviewed; Region: frr; PRK00083
297246004626	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
297246004627	hinge region; other site
297246004628	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
297246004629	putative nucleotide binding site [chemical binding]; other site
297246004630	uridine monophosphate binding site [chemical binding]; other site
297246004631	homohexameric interface [polypeptide binding]; other site
297246004632	elongation factor Ts; Provisional; Region: tsf; PRK09377
297246004633	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
297246004634	Elongation factor TS; Region: EF_TS; pfam00889
297246004635	Elongation factor TS; Region: EF_TS; pfam00889
297246004636	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
297246004637	rRNA interaction site [nucleotide binding]; other site
297246004638	S8 interaction site; other site
297246004639	putative laminin-1 binding site; other site
297246004640	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
297246004641	dimer interface [polypeptide binding]; other site
297246004642	SET domain; Region: SET; cl02566
297246004643	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246004644	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246004645	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
297246004646	active site
297246004647	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
297246004648	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
297246004649	metal binding triad; other site
297246004650	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
297246004651	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246004652	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
297246004653	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
297246004654	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
297246004655	nucleoside/Zn binding site; other site
297246004656	dimer interface [polypeptide binding]; other site
297246004657	catalytic motif [active]
297246004658	GMP synthase; Reviewed; Region: guaA; PRK00074
297246004659	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
297246004660	AMP/PPi binding site [chemical binding]; other site
297246004661	candidate oxyanion hole; other site
297246004662	catalytic triad [active]
297246004663	potential glutamine specificity residues [chemical binding]; other site
297246004664	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
297246004665	ATP Binding subdomain [chemical binding]; other site
297246004666	Ligand Binding sites [chemical binding]; other site
297246004667	Dimerization subdomain; other site
297246004668	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
297246004669	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
297246004670	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
297246004671	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
297246004672	active site
297246004673	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
297246004674	Switch I; other site
297246004675	Switch II; other site
297246004676	Septum formation topological specificity factor MinE; Region: MinE; cl00538
297246004677	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
297246004678	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
297246004679	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
297246004680	active site
297246004681	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
297246004682	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246004683	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
297246004684	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
297246004685	Walker A/P-loop; other site
297246004686	ATP binding site [chemical binding]; other site
297246004687	Q-loop/lid; other site
297246004688	ABC transporter signature motif; other site
297246004689	Walker B; other site
297246004690	D-loop; other site
297246004691	H-loop/switch region; other site
297246004692	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
297246004693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246004694	dimer interface [polypeptide binding]; other site
297246004695	conserved gate region; other site
297246004696	putative PBP binding loops; other site
297246004697	ABC-ATPase subunit interface; other site
297246004698	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
297246004699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246004700	dimer interface [polypeptide binding]; other site
297246004701	conserved gate region; other site
297246004702	putative PBP binding loops; other site
297246004703	ABC-ATPase subunit interface; other site
297246004704	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
297246004705	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
297246004706	NAD(P) binding site [chemical binding]; other site
297246004707	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
297246004708	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
297246004709	Cl- selectivity filter; other site
297246004710	Cl- binding residues [ion binding]; other site
297246004711	pore gating glutamate residue; other site
297246004712	dimer interface [polypeptide binding]; other site
297246004713	H+/Cl- coupling transport residue; other site
297246004714	anthranilate synthase; Provisional; Region: PRK13566
297246004715	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
297246004716	chorismate binding enzyme; Region: Chorismate_bind; cl10555
297246004717	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
297246004718	glutamine binding [chemical binding]; other site
297246004719	catalytic triad [active]
297246004720	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
297246004721	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
297246004722	Amidase; Region: Amidase; cl11426
297246004723	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
297246004724	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
297246004725	GatB domain; Region: GatB_Yqey; cl11497
297246004726	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246004727	CHASE2 domain; Region: CHASE2; cl01732
297246004728	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
297246004729	cyclase homology domain; Region: CHD; cd07302
297246004730	nucleotidyl binding site; other site
297246004731	metal binding site [ion binding]; metal-binding site
297246004732	dimer interface [polypeptide binding]; other site
297246004733	FecR protein; Region: FecR; pfam04773
297246004734	Helix-turn-helix domains; Region: HTH; cl00088
297246004735	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
297246004736	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
297246004737	trimerization site [polypeptide binding]; other site
297246004738	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
297246004739	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
297246004740	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246004741	catalytic residue [active]
297246004742	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
297246004743	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
297246004744	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
297246004745	active site
297246004746	dimerization interface [polypeptide binding]; other site
297246004747	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
297246004748	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
297246004749	tandem repeat interface [polypeptide binding]; other site
297246004750	oligomer interface [polypeptide binding]; other site
297246004751	active site residues [active]
297246004752	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
297246004753	Clp amino terminal domain; Region: Clp_N; pfam02861
297246004754	Clp amino terminal domain; Region: Clp_N; pfam02861
297246004755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004756	Walker A motif; other site
297246004757	ATP binding site [chemical binding]; other site
297246004758	Walker B motif; other site
297246004759	arginine finger; other site
297246004760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004761	Walker A motif; other site
297246004762	ATP binding site [chemical binding]; other site
297246004763	Walker B motif; other site
297246004764	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
297246004765	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
297246004766	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
297246004767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
297246004768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246004769	TIGR02099 family protein; Region: TIGR02099
297246004770	AsmA-like C-terminal region; Region: AsmA_2; cl15864
297246004771	flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161
297246004772	Flagellar FliJ protein; Region: FliJ; pfam02050
297246004773	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
297246004774	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
297246004775	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
297246004776	Walker A motif/ATP binding site; other site
297246004777	Walker B motif; other site
297246004778	Flagellar assembly protein FliH; Region: FliH; pfam02108
297246004779	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
297246004780	FliG C-terminal domain; Region: FliG_C; pfam01706
297246004781	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
297246004782	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
297246004783	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
297246004784	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
297246004785	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
297246004786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246004787	active site
297246004788	phosphorylation site [posttranslational modification]
297246004789	intermolecular recognition site; other site
297246004790	dimerization interface [polypeptide binding]; other site
297246004791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004792	Walker A motif; other site
297246004793	ATP binding site [chemical binding]; other site
297246004794	Walker B motif; other site
297246004795	arginine finger; other site
297246004796	Helix-turn-helix domains; Region: HTH; cl00088
297246004797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
297246004798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246004799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246004800	dimer interface [polypeptide binding]; other site
297246004801	phosphorylation site [posttranslational modification]
297246004802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246004803	ATP binding site [chemical binding]; other site
297246004804	G-X-G motif; other site
297246004805	recombination factor protein RarA; Reviewed; Region: PRK13342
297246004806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246004807	Walker A motif; other site
297246004808	ATP binding site [chemical binding]; other site
297246004809	Walker B motif; other site
297246004810	arginine finger; other site
297246004811	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
297246004812	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
297246004813	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
297246004814	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
297246004815	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246004816	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
297246004817	thioredoxin reductase; Provisional; Region: PRK10262
297246004818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
297246004819	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246004820	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
297246004821	active site residue [active]
297246004822	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
297246004823	rRNA binding site [nucleotide binding]; other site
297246004824	predicted 30S ribosome binding site; other site
297246004825	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
297246004826	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
297246004827	Predicted periplasmic protein [Function unknown]; Region: COG3698
297246004828	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
297246004829	JmjC domain, hydroxylase; Region: JmjC; cl15814
297246004830	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
297246004831	ATP cone domain; Region: ATP-cone; pfam03477
297246004832	ATP cone domain; Region: ATP-cone; pfam03477
297246004833	Class I ribonucleotide reductase; Region: RNR_I; cd01679
297246004834	active site
297246004835	dimer interface [polypeptide binding]; other site
297246004836	catalytic residues [active]
297246004837	effector binding site; other site
297246004838	R2 peptide binding site; other site
297246004839	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
297246004840	dimer interface [polypeptide binding]; other site
297246004841	putative radical transfer pathway; other site
297246004842	diiron center [ion binding]; other site
297246004843	tyrosyl radical; other site
297246004844	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
297246004845	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
297246004846	dimer interface [polypeptide binding]; other site
297246004847	putative anticodon binding site; other site
297246004848	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
297246004849	motif 1; other site
297246004850	active site
297246004851	motif 2; other site
297246004852	motif 3; other site
297246004853	peptide chain release factor 2; Validated; Region: prfB; PRK00578
297246004854	RF-1 domain; Region: RF-1; cl02875
297246004855	RF-1 domain; Region: RF-1; cl02875
297246004856	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
297246004857	flagellar motor protein MotD; Reviewed; Region: PRK09038
297246004858	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
297246004859	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246004860	ligand binding site [chemical binding]; other site
297246004861	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
297246004862	flagellar motor protein MotA; Validated; Region: PRK08124
297246004863	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
297246004864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
297246004865	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
297246004866	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
297246004867	DNA binding residues [nucleotide binding]
297246004868	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
297246004869	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
297246004870	P-loop; other site
297246004871	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
297246004872	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
297246004873	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246004874	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
297246004875	FHIPEP family; Region: FHIPEP; pfam00771
297246004876	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
297246004877	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
297246004878	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
297246004879	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
297246004880	FliP family; Region: FliP; cl00593
297246004881	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
297246004882	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
297246004883	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
297246004884	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
297246004885	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
297246004886	FAD binding domain; Region: FAD_binding_4; pfam01565
297246004887	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
297246004888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004889	NAD(P) binding site [chemical binding]; other site
297246004890	active site
297246004891	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246004892	Helix-turn-helix domains; Region: HTH; cl00088
297246004893	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
297246004894	dimerization interface [polypeptide binding]; other site
297246004895	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
297246004896	GTPase interaction site; other site
297246004897	catalytic residue [active]
297246004898	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
297246004899	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
297246004900	motif 1; other site
297246004901	active site
297246004902	motif 2; other site
297246004903	motif 3; other site
297246004904	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
297246004905	RecX family; Region: RecX; cl00936
297246004906	recombinase A; Provisional; Region: recA; PRK09354
297246004907	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
297246004908	hexamer interface [polypeptide binding]; other site
297246004909	Walker A motif; other site
297246004910	ATP binding site [chemical binding]; other site
297246004911	Walker B motif; other site
297246004912	Competence-damaged protein; Region: CinA; cl00666
297246004913	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
297246004914	MutS domain I; Region: MutS_I; pfam01624
297246004915	MutS domain II; Region: MutS_II; pfam05188
297246004916	MutS family domain IV; Region: MutS_IV; pfam05190
297246004917	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
297246004918	Walker A/P-loop; other site
297246004919	ATP binding site [chemical binding]; other site
297246004920	Q-loop/lid; other site
297246004921	ABC transporter signature motif; other site
297246004922	Walker B; other site
297246004923	D-loop; other site
297246004924	H-loop/switch region; other site
297246004925	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
297246004926	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
297246004927	Surface antigen; Region: Bac_surface_Ag; cl03097
297246004928	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
297246004929	Family of unknown function (DUF490); Region: DUF490; pfam04357
297246004930	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
297246004931	dimer interface [polypeptide binding]; other site
297246004932	active site
297246004933	Schiff base residues; other site
297246004934	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
297246004935	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
297246004936	AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259
297246004937	putative catalytic residues [active]
297246004938	putative nucleotide binding site [chemical binding]; other site
297246004939	putative aspartate binding site [chemical binding]; other site
297246004940	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
297246004941	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920
297246004942	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840
297246004943	active site
297246004944	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
297246004945	substrate binding site [chemical binding]; other site
297246004946	catalytic residues [active]
297246004947	dimer interface [polypeptide binding]; other site
297246004948	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
297246004949	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246004950	Family description; Region: UvrD_C_2; cl15862
297246004951	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
297246004952	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
297246004953	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
297246004954	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
297246004955	Helix-turn-helix domains; Region: HTH; cl00088
297246004956	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
297246004957	dimerization interface [polypeptide binding]; other site
297246004958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246004959	putative substrate translocation pore; other site
297246004960	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
297246004961	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
297246004962	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
297246004963	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246004964	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
297246004965	Walker A/P-loop; other site
297246004966	ATP binding site [chemical binding]; other site
297246004967	Q-loop/lid; other site
297246004968	ABC transporter signature motif; other site
297246004969	Walker B; other site
297246004970	D-loop; other site
297246004971	H-loop/switch region; other site
297246004972	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246004973	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
297246004974	quinone interaction residues [chemical binding]; other site
297246004975	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
297246004976	active site
297246004977	catalytic residues [active]
297246004978	FMN binding site [chemical binding]; other site
297246004979	substrate binding site [chemical binding]; other site
297246004980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246004981	isovaleryl-CoA dehydrogenase; Region: PLN02519
297246004982	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
297246004983	substrate binding site [chemical binding]; other site
297246004984	FAD binding site [chemical binding]; other site
297246004985	catalytic base [active]
297246004986	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
297246004987	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
297246004988	dimer interface [polypeptide binding]; other site
297246004989	active site
297246004990	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
297246004991	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246004992	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246004993	enoyl-CoA hydratase; Provisional; Region: PRK05995
297246004994	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
297246004995	substrate binding site [chemical binding]; other site
297246004996	oxyanion hole (OAH) forming residues; other site
297246004997	trimer interface [polypeptide binding]; other site
297246004998	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
297246004999	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
297246005000	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
297246005001	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246005002	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
297246005003	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
297246005004	carboxyltransferase (CT) interaction site; other site
297246005005	biotinylation site [posttranslational modification]; other site
297246005006	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
297246005007	active site
297246005008	catalytic residues [active]
297246005009	metal binding site [ion binding]; metal-binding site
297246005010	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
297246005011	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
297246005012	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005013	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246005014	VirK protein; Region: VirK; pfam06903
297246005015	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
297246005016	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
297246005017	Walker A/P-loop; other site
297246005018	ATP binding site [chemical binding]; other site
297246005019	Q-loop/lid; other site
297246005020	ABC transporter signature motif; other site
297246005021	Walker B; other site
297246005022	D-loop; other site
297246005023	H-loop/switch region; other site
297246005024	NIL domain; Region: NIL; cl09633
297246005025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
297246005026	dimer interface [polypeptide binding]; other site
297246005027	conserved gate region; other site
297246005028	ABC-ATPase subunit interface; other site
297246005029	NMT1-like family; Region: NMT1_2; cl15260
297246005030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005031	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
297246005032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246005033	active site
297246005034	motif I; other site
297246005035	motif II; other site
297246005036	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
297246005037	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
297246005038	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
297246005039	dimer interface [polypeptide binding]; other site
297246005040	motif 1; other site
297246005041	active site
297246005042	motif 2; other site
297246005043	motif 3; other site
297246005044	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
297246005045	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
297246005046	catalytic residues [active]
297246005047	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
297246005048	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005049	Family description; Region: UvrD_C_2; cl15862
297246005050	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
297246005051	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
297246005052	putative active site [active]
297246005053	dimerization interface [polypeptide binding]; other site
297246005054	putative tRNAtyr binding site [nucleotide binding]; other site
297246005055	VacJ like lipoprotein; Region: VacJ; cl01073
297246005056	glutathione synthetase; Provisional; Region: PRK05246
297246005057	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
297246005058	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246005059	Glutamate-cysteine ligase; Region: GshA; pfam08886
297246005060	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
297246005061	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246005062	GIY-YIG motif/motif A; other site
297246005063	putative active site [active]
297246005064	putative metal binding site [ion binding]; other site
297246005065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246005066	EamA-like transporter family; Region: EamA; cl01037
297246005067	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
297246005068	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
297246005069	active site residue [active]
297246005070	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
297246005071	PglZ domain; Region: PglZ; pfam08665
297246005072	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
297246005073	Sugar specificity; other site
297246005074	Pyrimidine base specificity; other site
297246005075	ATP-binding site [chemical binding]; other site
297246005076	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
297246005077	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
297246005078	NAD binding site [chemical binding]; other site
297246005079	homotetramer interface [polypeptide binding]; other site
297246005080	homodimer interface [polypeptide binding]; other site
297246005081	substrate binding site [chemical binding]; other site
297246005082	active site
297246005083	periplasmic folding chaperone; Provisional; Region: PRK10788
297246005084	SurA N-terminal domain; Region: SurA_N_3; cl07813
297246005085	PPIC-type PPIASE domain; Region: Rotamase; cl08278
297246005086	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
297246005087	IHF dimer interface [polypeptide binding]; other site
297246005088	IHF - DNA interface [nucleotide binding]; other site
297246005089	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
297246005090	Found in ATP-dependent protease La (LON); Region: LON; smart00464
297246005091	Found in ATP-dependent protease La (LON); Region: LON; smart00464
297246005092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246005093	Walker A motif; other site
297246005094	ATP binding site [chemical binding]; other site
297246005095	Walker B motif; other site
297246005096	arginine finger; other site
297246005097	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
297246005098	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
297246005099	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
297246005100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246005101	Walker A motif; other site
297246005102	ATP binding site [chemical binding]; other site
297246005103	Walker B motif; other site
297246005104	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
297246005105	Clp protease; Region: CLP_protease; pfam00574
297246005106	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
297246005107	oligomer interface [polypeptide binding]; other site
297246005108	active site residues [active]
297246005109	trigger factor; Provisional; Region: tig; PRK01490
297246005110	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
297246005111	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
297246005112	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
297246005113	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
297246005114	Int/Topo IB signature motif; other site
297246005115	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
297246005116	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005117	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005118	ABC transporter; Region: ABC_tran_2; pfam12848
297246005119	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005120	ribonuclease III; Reviewed; Region: rnc; PRK00102
297246005121	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
297246005122	dimerization interface [polypeptide binding]; other site
297246005123	active site
297246005124	metal binding site [ion binding]; metal-binding site
297246005125	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
297246005126	dsRNA binding site [nucleotide binding]; other site
297246005127	signal peptidase I; Provisional; Region: PRK10861
297246005128	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
297246005129	Catalytic site [active]
297246005130	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
297246005131	GTP-binding protein LepA; Provisional; Region: PRK05433
297246005132	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
297246005133	G1 box; other site
297246005134	putative GEF interaction site [polypeptide binding]; other site
297246005135	GTP/Mg2+ binding site [chemical binding]; other site
297246005136	Switch I region; other site
297246005137	G2 box; other site
297246005138	G3 box; other site
297246005139	Switch II region; other site
297246005140	G4 box; other site
297246005141	G5 box; other site
297246005142	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
297246005143	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
297246005144	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
297246005145	Transglycosylase SLT domain; Region: SLT_2; pfam13406
297246005146	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
297246005147	N-acetyl-D-glucosamine binding site [chemical binding]; other site
297246005148	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
297246005149	GspL periplasmic domain; Region: GspL_C; cl14909
297246005150	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
297246005151	Sporulation related domain; Region: SPOR; cl10051
297246005152	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
297246005153	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246005154	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
297246005155	DNA repair protein RecN; Region: recN; TIGR00634
297246005156	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
297246005157	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
297246005158	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
297246005159	dimer interface [polypeptide binding]; other site
297246005160	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246005161	active site
297246005162	metal binding site [ion binding]; metal-binding site
297246005163	glutathione binding site [chemical binding]; other site
297246005164	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
297246005165	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246005166	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
297246005167	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246005168	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246005169	GIY-YIG motif/motif A; other site
297246005170	putative active site [active]
297246005171	putative metal binding site [ion binding]; other site
297246005172	Acylphosphatase; Region: Acylphosphatase; cl00551
297246005173	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
297246005174	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
297246005175	putative active site [active]
297246005176	catalytic site [active]
297246005177	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246005178	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
297246005179	substrate binding pocket [chemical binding]; other site
297246005180	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246005181	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246005182	Leucine-rich repeats; other site
297246005183	Substrate binding site [chemical binding]; other site
297246005184	Leucine rich repeat; Region: LRR_8; pfam13855
297246005185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246005186	D-galactonate transporter; Region: 2A0114; TIGR00893
297246005187	putative substrate translocation pore; other site
297246005188	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
297246005189	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
297246005190	putative ion selectivity filter; other site
297246005191	putative pore gating glutamate residue; other site
297246005192	Transposase domain (DUF772); Region: DUF772; cl15789
297246005193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
297246005194	SEC-C motif; Region: SEC-C; pfam02810
297246005195	SEC-C motif; Region: SEC-C; pfam02810
297246005196	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
297246005197	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
297246005198	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
297246005199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005200	Similar to hypothetical protein;hypothetical protein
297246005201	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
297246005202	putative active site [active]
297246005203	Transposase domain (DUF772); Region: DUF772; cl15789
297246005204	MoxR-like ATPases [General function prediction only]; Region: COG0714
297246005205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246005206	Walker A motif; other site
297246005207	ATP binding site [chemical binding]; other site
297246005208	Walker B motif; other site
297246005209	arginine finger; other site
297246005210	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
297246005211	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
297246005212	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
297246005213	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
297246005214	Uncharacterized conserved protein [Function unknown]; Region: COG2850
297246005215	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246005216	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246005217	EamA-like transporter family; Region: EamA; cl01037
297246005218	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
297246005219	GDA1/CD39 (nucleoside phosphatase) family; Region: GDA1_CD39; cl02218
297246005220	Protein of unknown function, DUF462; Region: DUF462; cl01190
297246005221	glutathionine S-transferase; Provisional; Region: PRK10542
297246005222	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
297246005223	C-terminal domain interface [polypeptide binding]; other site
297246005224	GSH binding site (G-site) [chemical binding]; other site
297246005225	dimer interface [polypeptide binding]; other site
297246005226	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
297246005227	N-terminal domain interface [polypeptide binding]; other site
297246005228	dimer interface [polypeptide binding]; other site
297246005229	substrate binding pocket (H-site) [chemical binding]; other site
297246005230	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246005231	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
297246005232	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
297246005233	HIGH motif; other site
297246005234	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
297246005235	active site
297246005236	KMSKS motif; other site
297246005237	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
297246005238	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
297246005239	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246005240	dimer interface [polypeptide binding]; other site
297246005241	phosphorylation site [posttranslational modification]
297246005242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246005243	ATP binding site [chemical binding]; other site
297246005244	Mg2+ binding site [ion binding]; other site
297246005245	G-X-G motif; other site
297246005246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
297246005247	active site
297246005248	phosphorylation site [posttranslational modification]
297246005249	dimerization interface [polypeptide binding]; other site
297246005250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246005251	active site
297246005252	phosphorylation site [posttranslational modification]
297246005253	intermolecular recognition site; other site
297246005254	dimerization interface [polypeptide binding]; other site
297246005255	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
297246005256	putative binding surface; other site
297246005257	active site
297246005258	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
297246005259	active site
297246005260	ADP/pyrophosphate binding site [chemical binding]; other site
297246005261	dimerization interface [polypeptide binding]; other site
297246005262	allosteric effector site; other site
297246005263	fructose-1,6-bisphosphate binding site; other site
297246005264	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
297246005265	Pilin (bacterial filament); Region: Pilin; pfam00114
297246005266	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
297246005267	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
297246005268	Pilin (bacterial filament); Region: Pilin; pfam00114
297246005269	BolA-like protein; Region: BolA; cl00386
297246005270	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
297246005271	Calcium-activated chloride channel; Region: Anoctamin; pfam04547
297246005272	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
297246005273	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
297246005274	Ligand binding site; other site
297246005275	oligomer interface; other site
297246005276	Trm112p-like protein; Region: Trm112p; cl01066
297246005277	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
297246005278	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
297246005279	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005280	Ferredoxin [Energy production and conversion]; Region: COG1146
297246005281	4Fe-4S binding domain; Region: Fer4; cl02805
297246005282	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
297246005283	PilZ domain; Region: PilZ; cl01260
297246005284	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
297246005285	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
297246005286	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005287	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005288	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005289	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005290	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005291	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005292	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005293	similar to N-terminal part of  transposase (IS91 family);hypothetical protein
297246005294	hypothetical protein
297246005295	hypothetical protein
297246005296	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
297246005297	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005298	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
297246005299	HipA N-terminal domain; Region: Couple_hipA; cl11853
297246005300	HipA-like N-terminal domain; Region: HipA_N; pfam07805
297246005301	HipA-like C-terminal domain; Region: HipA_C; pfam07804
297246005302	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246005303	non-specific DNA binding site [nucleotide binding]; other site
297246005304	salt bridge; other site
297246005305	sequence-specific DNA binding site [nucleotide binding]; other site
297246005306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246005308	S-adenosylmethionine binding site [chemical binding]; other site
297246005309	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
297246005310	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005311	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
297246005312	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
297246005313	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
297246005314	active site
297246005315	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
297246005316	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005317	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005318	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
297246005319	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
297246005320	active site
297246005321	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
297246005322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005323	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
297246005324	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246005325	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
297246005326	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
297246005327	active site
297246005328	nucleophile elbow; other site
297246005329	Patatin phospholipase; Region: DUF3734; pfam12536
297246005330	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246005331	PAS fold; Region: PAS_4; pfam08448
297246005332	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246005333	DNA binding residues [nucleotide binding]
297246005334	dimerization interface [polypeptide binding]; other site
297246005335	Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171
297246005336	active site/putative ARF binding site [active]
297246005337	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
297246005338	putative lipid kinase; Reviewed; Region: PRK00861
297246005339	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
297246005340	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
297246005341	active site
297246005342	metal binding site [ion binding]; metal-binding site
297246005343	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
297246005344	DctM-like transporters; Region: DctM; pfam06808
297246005345	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
297246005346	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
297246005347	active site
297246005348	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246005349	Leucine-rich repeats; other site
297246005350	Substrate binding site [chemical binding]; other site
297246005351	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
297246005352	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246005353	GIY-YIG motif/motif A; other site
297246005354	putative active site [active]
297246005355	putative metal binding site [ion binding]; other site
297246005356	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246005357	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
297246005358	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
297246005359	active site
297246005360	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
297246005361	Helix-turn-helix domains; Region: HTH; cl00088
297246005362	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246005363	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
297246005364	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
297246005365	C-terminal domain interface [polypeptide binding]; other site
297246005366	GSH binding site (G-site) [chemical binding]; other site
297246005367	dimer interface [polypeptide binding]; other site
297246005368	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
297246005369	N-terminal domain interface [polypeptide binding]; other site
297246005370	dimer interface [polypeptide binding]; other site
297246005371	substrate binding pocket (H-site) [chemical binding]; other site
297246005372	OsmC-like protein; Region: OsmC; cl00767
297246005373	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
297246005374	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
297246005375	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
297246005376	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
297246005377	intracellular protease, PfpI family; Region: PfpI; TIGR01382
297246005378	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
297246005379	conserved cys residue [active]
297246005380	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
297246005381	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
297246005382	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
297246005383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005384	TPR repeat; Region: TPR_11; pfam13414
297246005385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246005386	binding surface
297246005387	TPR motif; other site
297246005388	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246005389	substrate binding site [chemical binding]; other site
297246005390	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
297246005391	guanine deaminase; Provisional; Region: PRK09228
297246005392	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246005393	active site
297246005394	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
297246005395	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
297246005396	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
297246005397	catalytic core [active]
297246005398	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
297246005399	MAPEG family; Region: MAPEG; cl09190
297246005400	YhhN-like protein; Region: YhhN; cl01505
297246005401	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
297246005402	NodB motif; other site
297246005403	putative active site [active]
297246005404	putative catalytic site [active]
297246005405	putative Zn binding site [ion binding]; other site
297246005406	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
297246005407	MltA specific insert domain; Region: MltA; cl08398
297246005408	3D domain; Region: 3D; cl01439
297246005409	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
297246005410	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
297246005411	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
297246005412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246005413	homodimer interface [polypeptide binding]; other site
297246005414	catalytic residue [active]
297246005415	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
297246005416	aromatic arch; other site
297246005417	DCoH dimer interaction site [polypeptide binding]; other site
297246005418	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
297246005419	DCoH tetramer interaction site [polypeptide binding]; other site
297246005420	substrate binding site [chemical binding]; other site
297246005421	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
297246005422	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
297246005423	Protein export membrane protein; Region: SecD_SecF; cl14618
297246005424	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
297246005425	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
297246005426	Protein export membrane protein; Region: SecD_SecF; cl14618
297246005427	Preprotein translocase subunit; Region: YajC; cl00806
297246005428	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
297246005429	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
297246005430	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
297246005431	ABC transporter ATPase component; Reviewed; Region: PRK11147
297246005432	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005433	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005434	ABC transporter; Region: ABC_tran_2; pfam12848
297246005435	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
297246005436	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
297246005437	catalytic motif [active]
297246005438	Catalytic residue [active]
297246005439	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
297246005440	homotrimer interaction site [polypeptide binding]; other site
297246005441	putative active site [active]
297246005442	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
297246005443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246005444	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
297246005445	synthetase active site [active]
297246005446	NTP binding site [chemical binding]; other site
297246005447	metal binding site [ion binding]; metal-binding site
297246005448	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
297246005449	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
297246005450	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
297246005451	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
297246005452	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
297246005453	catalytic site [active]
297246005454	G-X2-G-X-G-K; other site
297246005455	hypothetical protein; Provisional; Region: PRK11820
297246005456	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
297246005457	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
297246005458	ribonuclease PH; Reviewed; Region: rph; PRK00173
297246005459	Ribonuclease PH; Region: RNase_PH_bact; cd11362
297246005460	hexamer interface [polypeptide binding]; other site
297246005461	active site
297246005462	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
297246005463	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
297246005464	Walker A motif; other site
297246005465	ATP binding site [chemical binding]; other site
297246005466	Walker B motif; other site
297246005467	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
297246005468	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
297246005469	catalytic residue [active]
297246005470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005471	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
297246005472	YGGT family; Region: YGGT; cl00508
297246005473	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
297246005474	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
297246005475	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
297246005476	active site
297246005477	catalytic residues [active]
297246005478	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
297246005479	Helix-turn-helix domain; Region: HTH_18; pfam12833
297246005480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
297246005481	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
297246005482	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
297246005483	oligomerization interface [polypeptide binding]; other site
297246005484	active site
297246005485	NAD+ binding site [chemical binding]; other site
297246005486	S-adenosylmethionine synthetase; Validated; Region: PRK05250
297246005487	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
297246005488	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
297246005489	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
297246005490	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
297246005491	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
297246005492	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
297246005493	catalytic site [active]
297246005494	subunit interface [polypeptide binding]; other site
297246005495	chaperone protein DnaJ; Provisional; Region: PRK10767
297246005496	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
297246005497	HSP70 interaction site [polypeptide binding]; other site
297246005498	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
297246005499	substrate binding site [polypeptide binding]; other site
297246005500	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
297246005501	Zn binding sites [ion binding]; other site
297246005502	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
297246005503	dimer interface [polypeptide binding]; other site
297246005504	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
297246005505	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
297246005506	dimer interface [polypeptide binding]; other site
297246005507	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
297246005508	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
297246005509	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
297246005510	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
297246005511	substrate binding site [chemical binding]; other site
297246005512	active site
297246005513	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
297246005514	homooctamer interface [polypeptide binding]; other site
297246005515	active site
297246005516	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
297246005517	Sporulation related domain; Region: SPOR; cl10051
297246005518	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
297246005519	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
297246005520	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246005521	active site
297246005522	HIGH motif; other site
297246005523	nucleotide binding site [chemical binding]; other site
297246005524	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
297246005525	KMSK motif region; other site
297246005526	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
297246005527	tRNA binding surface [nucleotide binding]; other site
297246005528	anticodon binding site; other site
297246005529	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
297246005530	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
297246005531	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
297246005532	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
297246005533	generic binding surface II; other site
297246005534	ssDNA binding site; other site
297246005535	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246005536	ATP binding site [chemical binding]; other site
297246005537	putative Mg++ binding site [ion binding]; other site
297246005538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246005539	nucleotide binding region [chemical binding]; other site
297246005540	ATP-binding site [chemical binding]; other site
297246005541	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
297246005542	Cation efflux family; Region: Cation_efflux; cl00316
297246005543	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
297246005544	ZIP Zinc transporter; Region: Zip; pfam02535
297246005545	Maf-like protein; Region: Maf; pfam02545
297246005546	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
297246005547	active site
297246005548	dimer interface [polypeptide binding]; other site
297246005549	enolase; Provisional; Region: eno; PRK00077
297246005550	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
297246005551	dimer interface [polypeptide binding]; other site
297246005552	metal binding site [ion binding]; metal-binding site
297246005553	substrate binding pocket [chemical binding]; other site
297246005554	Septum formation initiator; Region: DivIC; cl11433
297246005555	mevalonate kinase; Region: mevalon_kin; TIGR00549
297246005556	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
297246005557	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
297246005558	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
297246005559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246005560	FeS/SAM binding site; other site
297246005561	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
297246005562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
297246005563	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246005564	ligand binding site [chemical binding]; other site
297246005565	Protein of unknown function (DUF330); Region: DUF330; cl01135
297246005566	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
297246005567	mce related protein; Region: MCE; pfam02470
297246005568	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
297246005569	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005570	Walker A/P-loop; other site
297246005571	ATP binding site [chemical binding]; other site
297246005572	Q-loop/lid; other site
297246005573	ABC transporter signature motif; other site
297246005574	Walker B; other site
297246005575	D-loop; other site
297246005576	H-loop/switch region; other site
297246005577	Permease; Region: Permease; cl00510
297246005578	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246005579	active site
297246005580	ATP binding site [chemical binding]; other site
297246005581	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
297246005582	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
297246005583	homotetramer interface [polypeptide binding]; other site
297246005584	FMN binding site [chemical binding]; other site
297246005585	homodimer contacts [polypeptide binding]; other site
297246005586	putative active site [active]
297246005587	putative substrate binding site [chemical binding]; other site
297246005588	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
297246005589	homodimer interface [polypeptide binding]; other site
297246005590	NAD binding site [chemical binding]; other site
297246005591	catalytic residues [active]
297246005592	substrate binding pocket [chemical binding]; other site
297246005593	flexible flap; other site
297246005594	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
297246005595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
297246005596	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246005597	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
297246005598	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
297246005599	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
297246005600	Similar to transposase (ISL3 family);hypothetical protein
297246005601	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246005602	DNA-binding site [nucleotide binding]; DNA binding site
297246005603	RNA-binding motif; other site
297246005604	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
297246005605	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
297246005606	ATP binding site [chemical binding]; other site
297246005607	Mg++ binding site [ion binding]; other site
297246005608	motif III; other site
297246005609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246005610	nucleotide binding region [chemical binding]; other site
297246005611	ATP-binding site [chemical binding]; other site
297246005612	DbpA RNA binding domain; Region: DbpA; pfam03880
297246005613	Cation efflux family; Region: Cation_efflux; cl00316
297246005614	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
297246005615	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
297246005616	Transposase domain (DUF772); Region: DUF772; cl15789
297246005617	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246005618	Transposase domain (DUF772); Region: DUF772; cl15789
297246005619	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
297246005620	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
297246005621	Similar to transposase (IS5 family);hypothetical protein
297246005622	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246005623	GIY-YIG motif/motif A; other site
297246005624	putative active site [active]
297246005625	putative metal binding site [ion binding]; other site
297246005626	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246005627	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
297246005628	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246005629	GIY-YIG motif/motif A; other site
297246005630	putative active site [active]
297246005631	putative metal binding site [ion binding]; other site
297246005632	Transposase domain (DUF772); Region: DUF772; cl15789
297246005633	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246005634	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005635	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246005636	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005637	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005638	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246005639	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005640	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005641	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005642	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246005643	Helix-turn-helix domains; Region: HTH; cl00088
297246005644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
297246005645	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246005646	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005647	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005648	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005649	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005650	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005651	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005652	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005653	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246005654	ligand binding site [chemical binding]; other site
297246005655	K+ potassium transporter; Region: K_trans; cl15781
297246005656	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005657	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005658	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246005659	Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143
297246005660	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246005661	PAS domain S-box; Region: sensory_box; TIGR00229
297246005662	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246005663	putative active site [active]
297246005664	heme pocket [chemical binding]; other site
297246005665	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246005666	metal binding site [ion binding]; metal-binding site
297246005667	active site
297246005668	I-site; other site
297246005669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246005670	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246005671	putative substrate translocation pore; other site
297246005672	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
297246005673	Protein export membrane protein; Region: SecD_SecF; cl14618
297246005674	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
297246005675	carboxyltransferase (CT) interaction site; other site
297246005676	biotinylation site [posttranslational modification]; other site
297246005677	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246005678	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
297246005679	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246005680	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246005681	active site
297246005682	ATP binding site [chemical binding]; other site
297246005683	substrate binding site [chemical binding]; other site
297246005684	activation loop (A-loop); other site
297246005685	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246005686	Helix-turn-helix domains; Region: HTH; cl00088
297246005687	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246005688	dimerization interface [polypeptide binding]; other site
297246005689	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
297246005690	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
297246005691	Helix-turn-helix domains; Region: HTH; cl00088
297246005692	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
297246005693	classical (c) SDRs; Region: SDR_c; cd05233
297246005694	NAD(P) binding site [chemical binding]; other site
297246005695	active site
297246005696	F-box domain; Region: F-box; cl02535
297246005697	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
297246005698	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005699	Response regulator receiver domain; Region: Response_reg; pfam00072
297246005700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246005701	active site
297246005702	phosphorylation site [posttranslational modification]
297246005703	intermolecular recognition site; other site
297246005704	dimerization interface [polypeptide binding]; other site
297246005705	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246005706	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
297246005707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246005708	dimer interface [polypeptide binding]; other site
297246005709	phosphorylation site [posttranslational modification]
297246005710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246005711	ATP binding site [chemical binding]; other site
297246005712	Mg2+ binding site [ion binding]; other site
297246005713	G-X-G motif; other site
297246005714	Response regulator receiver domain; Region: Response_reg; pfam00072
297246005715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246005716	active site
297246005717	phosphorylation site [posttranslational modification]
297246005718	intermolecular recognition site; other site
297246005719	dimerization interface [polypeptide binding]; other site
297246005720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246005721	dimer interface [polypeptide binding]; other site
297246005722	phosphorylation site [posttranslational modification]
297246005723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246005724	ATP binding site [chemical binding]; other site
297246005725	Mg2+ binding site [ion binding]; other site
297246005726	G-X-G motif; other site
297246005727	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
297246005728	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
297246005729	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246005730	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246005731	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
297246005732	Walker A/P-loop; other site
297246005733	ATP binding site [chemical binding]; other site
297246005734	Q-loop/lid; other site
297246005735	ABC transporter signature motif; other site
297246005736	Walker B; other site
297246005737	D-loop; other site
297246005738	H-loop/switch region; other site
297246005739	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005740	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005741	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005742	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005743	Dot/Icm substrate protein; Region: SidE; pfam12252
297246005744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246005745	S-adenosylmethionine binding site [chemical binding]; other site
297246005746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246005748	S-adenosylmethionine binding site [chemical binding]; other site
297246005749	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
297246005750	Helix-turn-helix domains; Region: HTH; cl00088
297246005751	WYL domain; Region: WYL; cl14852
297246005752	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
297246005753	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246005754	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
297246005755	putative dimer interface [polypeptide binding]; other site
297246005756	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246005757	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246005758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246005759	Coenzyme A binding pocket [chemical binding]; other site
297246005760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005761	active site
297246005762	NAD+ binding site [chemical binding]; other site
297246005763	oligomerization interface [polypeptide binding]; other site
297246005764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246005765	non-specific DNA binding site [nucleotide binding]; other site
297246005766	salt bridge; other site
297246005767	sequence-specific DNA binding site [nucleotide binding]; other site
297246005768	hypothetical protein; Validated; Region: PRK07078
297246005769	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
297246005770	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
297246005771	active site
297246005772	metal binding site [ion binding]; metal-binding site
297246005773	interdomain interaction site; other site
297246005774	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005775	Walker A motif; other site
297246005776	ATP binding site [chemical binding]; other site
297246005777	Walker B motif; other site
297246005778	Helix-turn-helix domain; Region: HTH_39; pfam14090
297246005779	integrase; Provisional; Region: int; PHA02601
297246005780	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
297246005781	DNA binding site [nucleotide binding]
297246005782	Int/Topo IB signature motif; other site
297246005783	active site
297246005784	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
297246005785	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246005786	active site
297246005787	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
297246005788	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
297246005789	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246005790	catalytic residue [active]
297246005791	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246005792	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246005793	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246005794	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
297246005795	N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649
297246005796	putative active site [active]
297246005797	putative substrate binding site [chemical binding]; other site
297246005798	putative cosubstrate binding site; other site
297246005799	catalytic site [active]
297246005800	C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700
297246005801	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
297246005802	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005803	acyl-CoA synthetase; Validated; Region: PRK08308
297246005804	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246005805	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
297246005806	PAS domain; Region: PAS_9; pfam13426
297246005807	PAS fold; Region: PAS_4; pfam08448
297246005808	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
297246005809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246005810	dimer interface [polypeptide binding]; other site
297246005811	phosphorylation site [posttranslational modification]
297246005812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246005813	ATP binding site [chemical binding]; other site
297246005814	Mg2+ binding site [ion binding]; other site
297246005815	G-X-G motif; other site
297246005816	Response regulator receiver domain; Region: Response_reg; pfam00072
297246005817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246005818	active site
297246005819	phosphorylation site [posttranslational modification]
297246005820	intermolecular recognition site; other site
297246005821	dimerization interface [polypeptide binding]; other site
297246005822	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
297246005823	putative binding surface; other site
297246005824	active site
297246005825	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
297246005826	Response regulator receiver domain; Region: Response_reg; pfam00072
297246005827	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246005828	active site
297246005829	phosphorylation site [posttranslational modification]
297246005830	intermolecular recognition site; other site
297246005831	dimerization interface [polypeptide binding]; other site
297246005832	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
297246005833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246005834	S-adenosylmethionine binding site [chemical binding]; other site
297246005835	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
297246005836	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
297246005837	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
297246005838	active site
297246005839	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
297246005840	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
297246005841	active site
297246005842	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
297246005843	NADP binding site [chemical binding]; other site
297246005844	active site
297246005845	acyl-CoA synthetase; Validated; Region: PRK06060
297246005846	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246005847	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
297246005848	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
297246005849	active site
297246005850	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
297246005851	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
297246005852	putative NADP binding site [chemical binding]; other site
297246005853	active site
297246005854	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246005855	Condensation domain; Region: Condensation; pfam00668
297246005856	Integral membrane protein TerC family; Region: TerC; cl10468
297246005857	Peptidase C80 family; Region: Peptidase_C80; pfam11713
297246005858	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246005859	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246005860	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
297246005861	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
297246005862	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
297246005863	putative dimer interface [polypeptide binding]; other site
297246005864	Sulfate transporter family; Region: Sulfate_transp; cl15842
297246005865	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
297246005866	active site clefts [active]
297246005867	zinc binding site [ion binding]; other site
297246005868	dimer interface [polypeptide binding]; other site
297246005869	ornithine cyclodeaminase; Validated; Region: PRK08618
297246005870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005871	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
297246005872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246005873	S-adenosylmethionine binding site [chemical binding]; other site
297246005874	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
297246005875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246005876	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
297246005877	hypothetical protein; Reviewed; Region: PRK09588
297246005878	Archease protein family (MTH1598/TM1083); Region: Archease; cl00606
297246005879	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
297246005880	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
297246005881	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
297246005882	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
297246005883	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
297246005884	putative NAD(P) binding site [chemical binding]; other site
297246005885	dimer interface [polypeptide binding]; other site
297246005886	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
297246005887	substrate binding site [chemical binding]; other site
297246005888	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
297246005889	YARHG domain; Region: YARHG; pfam13308
297246005890	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
297246005891	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
297246005892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246005893	TIGR01777 family protein; Region: yfcH
297246005894	NAD(P) binding site [chemical binding]; other site
297246005895	active site
297246005896	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246005897	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246005898	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
297246005899	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
297246005900	nudix motif; other site
297246005901	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
297246005902	active site
297246005903	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
297246005904	iron-sulfur cluster [ion binding]; other site
297246005905	[2Fe-2S] cluster binding site [ion binding]; other site
297246005906	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
297246005907	hydrophobic ligand binding site; other site
297246005908	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
297246005909	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
297246005910	putative trimer interface [polypeptide binding]; other site
297246005911	putative CoA binding site [chemical binding]; other site
297246005912	Sel1 repeat; Region: Sel1; cl02723
297246005913	Sel1 repeat; Region: Sel1; cl02723
297246005914	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246005915	Sel1 repeat; Region: Sel1; cl02723
297246005916	Sel1 repeat; Region: Sel1; cl02723
297246005917	Sel1 repeat; Region: Sel1; cl02723
297246005918	Sel1 repeat; Region: Sel1; cl02723
297246005919	Sel1 repeat; Region: Sel1; cl02723
297246005920	Sel1 repeat; Region: Sel1; cl02723
297246005921	GH3 auxin-responsive promoter; Region: GH3; cl04006
297246005922	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
297246005923	active site
297246005924	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
297246005925	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246005926	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246005927	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
297246005928	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
297246005929	active site
297246005930	acyl-CoA synthetase; Validated; Region: PRK05850
297246005931	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005932	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
297246005933	AMP-binding enzyme; Region: AMP-binding; cl15778
297246005934	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
297246005935	classical (c) SDRs; Region: SDR_c; cd05233
297246005936	NAD(P) binding site [chemical binding]; other site
297246005937	active site
297246005938	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
297246005939	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
297246005940	dimer interface [polypeptide binding]; other site
297246005941	active site
297246005942	CoA binding pocket [chemical binding]; other site
297246005943	Phosphopantetheine attachment site; Region: PP-binding; cl09936
297246005944	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
297246005945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246005946	putative substrate translocation pore; other site
297246005947	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
297246005948	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
297246005949	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
297246005950	Low-spin heme binding site [chemical binding]; other site
297246005951	D-pathway; other site
297246005952	Putative water exit pathway; other site
297246005953	Binuclear center (active site) [active]
297246005954	K-pathway; other site
297246005955	Putative proton exit pathway; other site
297246005956	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
297246005957	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
297246005958	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246005959	Walker A/P-loop; other site
297246005960	ATP binding site [chemical binding]; other site
297246005961	Q-loop/lid; other site
297246005962	ABC transporter signature motif; other site
297246005963	Walker B; other site
297246005964	D-loop; other site
297246005965	H-loop/switch region; other site
297246005966	MAPEG family; Region: MAPEG; cl09190
297246005967	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246005968	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246005969	hypothetical protein; Validated; Region: PRK07198
297246005970	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
297246005971	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
297246005972	dimerization interface [polypeptide binding]; other site
297246005973	active site
297246005974	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
297246005975	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246005976	active site
297246005977	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
297246005978	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
297246005979	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
297246005980	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
297246005981	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
297246005982	catalytic triad [active]
297246005983	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
297246005984	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
297246005985	putative active site [active]
297246005986	metal binding site [ion binding]; metal-binding site
297246005987	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
297246005988	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
297246005989	NAD(P) binding site [chemical binding]; other site
297246005990	catalytic residues [active]
297246005991	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
297246005992	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
297246005993	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
297246005994	Protein of unknown function (DUF692); Region: DUF692; cl01263
297246005995	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
297246005996	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246005997	Beta-Casp domain; Region: Beta-Casp; cl12567
297246005998	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
297246005999	BON domain; Region: BON; cl02771
297246006000	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
297246006001	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
297246006002	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
297246006003	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
297246006004	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
297246006005	dimer interaction site [polypeptide binding]; other site
297246006006	substrate-binding tunnel; other site
297246006007	active site
297246006008	catalytic site [active]
297246006009	substrate binding site [chemical binding]; other site
297246006010	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
297246006011	Acetokinase family; Region: Acetate_kinase; cl01029
297246006012	propionate/acetate kinase; Provisional; Region: PRK12379
297246006013	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
297246006014	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
297246006015	HSP70 interaction site [polypeptide binding]; other site
297246006016	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
297246006017	substrate binding site [polypeptide binding]; other site
297246006018	dimer interface [polypeptide binding]; other site
297246006019	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
297246006020	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
297246006021	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
297246006022	putative acyl-acceptor binding pocket; other site
297246006023	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
297246006024	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246006025	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
297246006026	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
297246006027	active site
297246006028	probable DNA repair protein; Region: TIGR03623
297246006029	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
297246006030	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
297246006031	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
297246006032	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
297246006033	putative NAD(P) binding site [chemical binding]; other site
297246006034	Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290
297246006035	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
297246006036	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
297246006037	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
297246006038	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
297246006039	putative active site [active]
297246006040	catalytic site [active]
297246006041	putative metal binding site [ion binding]; other site
297246006042	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
297246006043	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
297246006044	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
297246006045	NAD binding site [chemical binding]; other site
297246006046	Phe binding site; other site
297246006047	O-methyltransferase; Region: Methyltransf_3; pfam01596
297246006048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006049	S-adenosylmethionine binding site [chemical binding]; other site
297246006050	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
297246006051	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
297246006052	dimer interface [polypeptide binding]; other site
297246006053	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
297246006054	active site
297246006055	Fe binding site [ion binding]; other site
297246006056	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
297246006057	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
297246006058	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
297246006059	maleylacetoacetate isomerase; Region: maiA; TIGR01262
297246006060	C-terminal domain interface [polypeptide binding]; other site
297246006061	GSH binding site (G-site) [chemical binding]; other site
297246006062	putative dimer interface [polypeptide binding]; other site
297246006063	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
297246006064	dimer interface [polypeptide binding]; other site
297246006065	N-terminal domain interface [polypeptide binding]; other site
297246006066	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
297246006067	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
297246006068	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
297246006069	putative dimer interface [polypeptide binding]; other site
297246006070	putative anticodon binding site; other site
297246006071	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
297246006072	homodimer interface [polypeptide binding]; other site
297246006073	motif 1; other site
297246006074	motif 2; other site
297246006075	active site
297246006076	motif 3; other site
297246006077	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
297246006078	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
297246006079	Walker A/P-loop; other site
297246006080	ATP binding site [chemical binding]; other site
297246006081	Q-loop/lid; other site
297246006082	ABC transporter signature motif; other site
297246006083	Walker B; other site
297246006084	D-loop; other site
297246006085	H-loop/switch region; other site
297246006086	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
297246006087	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
297246006088	FtsX-like permease family; Region: FtsX; cl15850
297246006089	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
297246006090	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
297246006091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246006092	motif II; other site
297246006093	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
297246006094	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
297246006095	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
297246006096	active site
297246006097	ribonuclease E; Reviewed; Region: rne; PRK10811
297246006098	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
297246006099	homodimer interface [polypeptide binding]; other site
297246006100	oligonucleotide binding site [chemical binding]; other site
297246006101	Similar to transposase (IS4 family);hypothetical protein
297246006102	Similar to transposase (IS4 family);hypothetical protein
297246006103	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
297246006104	ATP-dependent helicase HepA; Validated; Region: PRK04914
297246006105	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246006106	ATP binding site [chemical binding]; other site
297246006107	putative Mg++ binding site [ion binding]; other site
297246006108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246006109	nucleotide binding region [chemical binding]; other site
297246006110	ATP-binding site [chemical binding]; other site
297246006111	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246006112	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
297246006113	Smr domain; Region: Smr; cl02619
297246006114	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
297246006115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006116	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
297246006117	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
297246006118	Tetramer interface [polypeptide binding]; other site
297246006119	active site
297246006120	FMN-binding site [chemical binding]; other site
297246006121	HemK family putative methylases; Region: hemK_fam; TIGR00536
297246006122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006123	S-adenosylmethionine binding site [chemical binding]; other site
297246006124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
297246006125	Smr domain; Region: Smr; cl02619
297246006126	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
297246006127	active site residue [active]
297246006128	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
297246006129	GSH binding site [chemical binding]; other site
297246006130	catalytic residues [active]
297246006131	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
297246006132	SecA binding site; other site
297246006133	Preprotein binding site; other site
297246006134	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
297246006135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006136	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
297246006137	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
297246006138	conserved hypothetical protein; Region: QEGLA; TIGR02421
297246006139	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
297246006140	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
297246006141	dihydrodipicolinate synthase; Region: dapA; TIGR00674
297246006142	dimer interface [polypeptide binding]; other site
297246006143	active site
297246006144	catalytic residue [active]
297246006145	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
297246006146	classical (c) SDRs; Region: SDR_c; cd05233
297246006147	NAD(P) binding site [chemical binding]; other site
297246006148	active site
297246006149	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
297246006150	nucleophile elbow; other site
297246006151	Patatin phospholipase; Region: DUF3734; pfam12536
297246006152	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
297246006153	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
297246006154	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
297246006155	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
297246006156	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246006157	ligand binding site [chemical binding]; other site
297246006158	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
297246006159	Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776
297246006160	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
297246006161	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246006162	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
297246006163	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006164	ATP binding site [chemical binding]; other site
297246006165	Walker B motif; other site
297246006166	sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678
297246006167	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246006168	DNA repair protein RadA; Provisional; Region: PRK11823
297246006169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006170	Walker A motif; other site
297246006171	ATP binding site [chemical binding]; other site
297246006172	Walker B motif; other site
297246006173	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
297246006174	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
297246006175	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
297246006176	substrate binding pocket [chemical binding]; other site
297246006177	chain length determination region; other site
297246006178	substrate-Mg2+ binding site; other site
297246006179	catalytic residues [active]
297246006180	aspartate-rich region 1; other site
297246006181	active site lid residues [active]
297246006182	aspartate-rich region 2; other site
297246006183	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
297246006184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006185	S-adenosylmethionine binding site [chemical binding]; other site
297246006186	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
297246006187	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246006188	active site
297246006189	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
297246006190	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
297246006191	active site
297246006192	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
297246006193	protein binding site [polypeptide binding]; other site
297246006194	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
297246006195	putative substrate binding region [chemical binding]; other site
297246006196	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
297246006197	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
297246006198	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
297246006199	tRNA; other site
297246006200	putative tRNA binding site [nucleotide binding]; other site
297246006201	putative NADP binding site [chemical binding]; other site
297246006202	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
297246006203	peptide chain release factor 1; Validated; Region: prfA; PRK00591
297246006204	RF-1 domain; Region: RF-1; cl02875
297246006205	RF-1 domain; Region: RF-1; cl02875
297246006206	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
297246006207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006208	S-adenosylmethionine binding site [chemical binding]; other site
297246006209	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
297246006210	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246006211	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
297246006212	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
297246006213	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
297246006214	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
297246006215	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
297246006216	putative metal binding site [ion binding]; other site
297246006217	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
297246006218	HSP70 interaction site [polypeptide binding]; other site
297246006219	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
297246006220	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
297246006221	active site
297246006222	catalytic triad [active]
297246006223	oxyanion hole [active]
297246006224	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
297246006225	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
297246006226	ATP binding site [chemical binding]; other site
297246006227	Mg++ binding site [ion binding]; other site
297246006228	motif III; other site
297246006229	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
297246006230	nucleotide binding region [chemical binding]; other site
297246006231	ATP-binding site [chemical binding]; other site
297246006232	DbpA RNA binding domain; Region: DbpA; pfam03880
297246006233	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
297246006234	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
297246006235	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
297246006236	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
297246006237	active site
297246006238	FMN binding site [chemical binding]; other site
297246006239	2,4-decadienoyl-CoA binding site; other site
297246006240	catalytic residue [active]
297246006241	4Fe-4S cluster binding site [ion binding]; other site
297246006242	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006243	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
297246006244	E-class dimer interface [polypeptide binding]; other site
297246006245	P-class dimer interface [polypeptide binding]; other site
297246006246	active site
297246006247	Cu2+ binding site [ion binding]; other site
297246006248	Zn2+ binding site [ion binding]; other site
297246006249	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
297246006250	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
297246006251	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
297246006252	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
297246006253	dimer interface [polypeptide binding]; other site
297246006254	decamer (pentamer of dimers) interface [polypeptide binding]; other site
297246006255	catalytic triad [active]
297246006256	peroxidatic and resolving cysteines [active]
297246006257	malate dehydrogenase; Provisional; Region: PRK05442
297246006258	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
297246006259	NAD(P) binding site [chemical binding]; other site
297246006260	dimer interface [polypeptide binding]; other site
297246006261	malate binding site [chemical binding]; other site
297246006262	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
297246006263	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
297246006264	dimer interface [polypeptide binding]; other site
297246006265	ADP-ribose binding site [chemical binding]; other site
297246006266	active site
297246006267	nudix motif; other site
297246006268	metal binding site [ion binding]; metal-binding site
297246006269	HemN family oxidoreductase; Provisional; Region: PRK05660
297246006270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
297246006271	FeS/SAM binding site; other site
297246006272	HemN C-terminal domain; Region: HemN_C; pfam06969
297246006273	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
297246006274	Amidase; Region: Amidase; cl11426
297246006275	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
297246006276	UGMP family protein; Validated; Region: PRK09604
297246006277	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
297246006278	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
297246006279	GatB domain; Region: GatB_Yqey; cl11497
297246006280	DNA primase; Validated; Region: dnaG; PRK05667
297246006281	CHC2 zinc finger; Region: zf-CHC2; cl15369
297246006282	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
297246006283	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
297246006284	active site
297246006285	metal binding site [ion binding]; metal-binding site
297246006286	interdomain interaction site; other site
297246006287	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
297246006288	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
297246006289	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
297246006290	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
297246006291	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
297246006292	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
297246006293	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
297246006294	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
297246006295	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
297246006296	DNA binding residues [nucleotide binding]
297246006297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
297246006298	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246006299	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
297246006300	DNA binding site [nucleotide binding]
297246006301	Int/Topo IB signature motif; other site
297246006302	active site
297246006303	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246006304	Coenzyme A binding pocket [chemical binding]; other site
297246006305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006306	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246006307	putative substrate translocation pore; other site
297246006308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
297246006309	Coenzyme A binding pocket [chemical binding]; other site
297246006310	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246006311	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246006312	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246006313	DNA binding residues [nucleotide binding]
297246006314	dimerization interface [polypeptide binding]; other site
297246006315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006316	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246006317	DNA-binding site [nucleotide binding]; DNA binding site
297246006318	RNA-binding motif; other site
297246006319	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
297246006320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006321	NAD(P) binding site [chemical binding]; other site
297246006322	active site
297246006323	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
297246006324	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
297246006325	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
297246006326	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246006327	metal binding site [ion binding]; metal-binding site
297246006328	active site
297246006329	I-site; other site
297246006330	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246006331	Heme NO binding; Region: HNOB; cl15268
297246006332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246006333	non-specific DNA binding site [nucleotide binding]; other site
297246006334	salt bridge; other site
297246006335	sequence-specific DNA binding site [nucleotide binding]; other site
297246006336	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
297246006337	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
297246006338	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
297246006339	alpha subunit interaction interface [polypeptide binding]; other site
297246006340	Walker A motif; other site
297246006341	ATP binding site [chemical binding]; other site
297246006342	Walker B motif; other site
297246006343	inhibitor binding site; inhibition site
297246006344	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
297246006345	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
297246006346	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
297246006347	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
297246006348	ATP synthase A chain; Region: ATP-synt_A; cl00413
297246006349	ATP synthase subunit C; Region: ATP-synt_C; cl00466
297246006350	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
297246006351	Plant ATP synthase F0; Region: YMF19; cl07975
297246006352	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
297246006353	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006354	Walker A motif; other site
297246006355	ATP binding site [chemical binding]; other site
297246006356	Walker B motif; other site
297246006357	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
297246006358	ATP synthase; Region: ATP-synt; cl00365
297246006359	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
297246006360	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
297246006361	FAD binding pocket [chemical binding]; other site
297246006362	FAD binding motif [chemical binding]; other site
297246006363	phosphate binding motif [ion binding]; other site
297246006364	beta-alpha-beta structure motif; other site
297246006365	NAD binding pocket [chemical binding]; other site
297246006366	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
297246006367	catalytic loop [active]
297246006368	iron binding site [ion binding]; other site
297246006369	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
297246006370	heme-binding residues [chemical binding]; other site
297246006371	Phospholipid methyltransferase; Region: PEMT; cl00763
297246006372	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
297246006373	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
297246006374	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
297246006375	NAD(P) binding site [chemical binding]; other site
297246006376	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246006377	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246006378	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246006379	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
297246006380	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
297246006381	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
297246006382	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
297246006383	Protein export membrane protein; Region: SecD_SecF; cl14618
297246006384	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
297246006385	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
297246006386	carboxyltransferase (CT) interaction site; other site
297246006387	biotinylation site [posttranslational modification]; other site
297246006388	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246006389	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
297246006390	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246006391	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
297246006392	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246006393	metal binding site [ion binding]; metal-binding site
297246006394	active site
297246006395	I-site; other site
297246006396	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
297246006397	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246006398	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246006399	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
297246006400	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
297246006401	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
297246006402	active site
297246006403	thymidine phosphorylase; Provisional; Region: PRK04350
297246006404	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
297246006405	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
297246006406	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
297246006407	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
297246006408	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246006409	Beta-Casp domain; Region: Beta-Casp; cl12567
297246006410	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
297246006411	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
297246006412	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
297246006413	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246006414	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246006415	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
297246006416	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
297246006417	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246006418	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
297246006419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246006420	motif II; other site
297246006421	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
297246006422	Domain of unknown function DUF302; Region: DUF302; cl01364
297246006423	similar to cadmium-transporting ATPase (C-terminal part);hypothetical protein
297246006424	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
297246006425	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
297246006426	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246006427	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246006428	heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914
297246006429	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
297246006430	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
297246006431	E3 interaction surface; other site
297246006432	lipoyl attachment site [posttranslational modification]; other site
297246006433	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246006434	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246006435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246006436	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
297246006437	non-specific DNA binding site [nucleotide binding]; other site
297246006438	salt bridge; other site
297246006439	sequence-specific DNA binding site [nucleotide binding]; other site
297246006440	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
297246006441	Catalytic site [active]
297246006442	Global regulator protein family; Region: CsrA; cl00670
297246006443	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
297246006444	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
297246006445	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
297246006446	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
297246006447	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
297246006448	Protein of unknown function (DUF3487); Region: DUF3487; cl13432
297246006449	Protein of unknown function (DUF2895); Region: DUF2895; cl12968
297246006450	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
297246006451	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
297246006452	bZIP transcription factor; Region: bZIP_1; cl02576
297246006453	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
297246006454	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
297246006455	Domain of unknown function DUF87; Region: DUF87; pfam01935
297246006456	TraU protein; Region: TraU; cl06067
297246006457	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
297246006458	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
297246006459	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
297246006460	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006461	Walker A motif; other site
297246006462	ATP binding site [chemical binding]; other site
297246006463	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
297246006464	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
297246006465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
297246006466	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246006467	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
297246006468	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
297246006469	EamA-like transporter family; Region: EamA; cl01037
297246006470	Antirestriction protein (ArdA); Region: ArdA; cl01953
297246006471	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
297246006472	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
297246006473	Transposase; Region: DDE_Tnp_ISL3; pfam01610
297246006474	Similar to transposase (ISL3 family) - partial;hypothetical protein
297246006475	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
297246006476	similar to unknown proteins;hypothetical protein
297246006477	Similar to transposase - partial;hypothetical protein
297246006478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006479	S-adenosylmethionine binding site [chemical binding]; other site
297246006480	Transposase IS200 like; Region: Y1_Tnp; cl00848
297246006481	similar to unknown protein;hypothetical protein
297246006482	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
297246006483	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
297246006484	non-specific DNA binding site [nucleotide binding]; other site
297246006485	salt bridge; other site
297246006486	sequence-specific DNA binding site [nucleotide binding]; other site
297246006487	HipA N-terminal domain; Region: Couple_hipA; cl11853
297246006488	similar to transposase, partial;hypothetical protein
297246006489	Cupin domain; Region: Cupin_2; cl09118
297246006490	hypothetical protein; Provisional; Region: PRK07206
297246006491	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246006492	H+ Antiporter protein; Region: 2A0121; TIGR00900
297246006493	Flavin Reductases; Region: FlaRed; cl00801
297246006494	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
297246006495	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
297246006496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006497	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246006498	putative substrate translocation pore; other site
297246006499	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
297246006500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246006501	Helix-turn-helix domains; Region: HTH; cl00088
297246006502	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
297246006503	substrate binding pocket [chemical binding]; other site
297246006504	dimerization interface [polypeptide binding]; other site
297246006505	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246006506	Helix-turn-helix domains; Region: HTH; cl00088
297246006507	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
297246006508	putative effector binding pocket; other site
297246006509	dimerization interface [polypeptide binding]; other site
297246006510	potassium uptake protein; Region: kup; TIGR00794
297246006511	K+ potassium transporter; Region: K_trans; cl15781
297246006512	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
297246006513	universal stress protein UspE; Provisional; Region: PRK11175
297246006514	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
297246006515	Ligand Binding Site [chemical binding]; other site
297246006516	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
297246006517	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
297246006518	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246006519	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
297246006520	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246006521	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
297246006522	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006523	AAA domain; Region: AAA_18; pfam13238
297246006524	Omptin family; Region: Omptin; cl01886
297246006525	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
297246006526	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
297246006527	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
297246006528	dimer interface [polypeptide binding]; other site
297246006529	active site
297246006530	heme binding site [chemical binding]; other site
297246006531	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
297246006532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006533	metabolite-proton symporter; Region: 2A0106; TIGR00883
297246006534	putative substrate translocation pore; other site
297246006535	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
297246006536	Substrate binding site [chemical binding]; other site
297246006537	Ferritin-like domain; Region: Ferritin; pfam00210
297246006538	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
297246006539	dinuclear metal binding motif [ion binding]; other site
297246006540	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
297246006541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006542	S-adenosylmethionine binding site [chemical binding]; other site
297246006543	Peptidase family M23; Region: Peptidase_M23; pfam01551
297246006544	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
297246006545	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246006546	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
297246006547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339; cl15420
297246006548	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246006549	Transcriptional regulator [Transcription]; Region: LysR; COG0583
297246006550	Helix-turn-helix domains; Region: HTH; cl00088
297246006551	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
297246006552	putative substrate binding pocket [chemical binding]; other site
297246006553	putative dimerization interface [polypeptide binding]; other site
297246006554	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
297246006555	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
297246006556	nudix motif; other site
297246006557	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246006558	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
297246006559	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
297246006560	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246006561	metal binding site [ion binding]; metal-binding site
297246006562	active site
297246006563	I-site; other site
297246006564	GAF domain; Region: GAF_2; pfam13185
297246006565	GAF domain; Region: GAF; cl15785
297246006566	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
297246006567	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
297246006568	active site
297246006569	nucleophile elbow; other site
297246006570	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246006571	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
297246006572	F-box domain; Region: F-box; cl02535
297246006573	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
297246006574	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
297246006575	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
297246006576	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
297246006577	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
297246006578	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246006579	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
297246006580	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913
297246006581	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
297246006582	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
297246006583	Acyl transferase domain; Region: Acyl_transf_1; cl08282
297246006584	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
297246006585	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
297246006586	active site
297246006587	metal binding site [ion binding]; metal-binding site
297246006588	Cupin domain; Region: Cupin_2; cl09118
297246006589	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
297246006590	Avidin family; Region: Avidin; pfam01382
297246006591	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
297246006592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006593	putative substrate translocation pore; other site
297246006594	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
297246006595	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
297246006596	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
297246006597	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
297246006598	putative dimer interface [polypeptide binding]; other site
297246006599	N-terminal domain interface [polypeptide binding]; other site
297246006600	putative substrate binding pocket (H-site) [chemical binding]; other site
297246006601	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
297246006602	dimer interface [polypeptide binding]; other site
297246006603	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
297246006604	dimer interface [polypeptide binding]; other site
297246006605	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
297246006606	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
297246006607	N-acetyltransferase; Region: Acetyltransf_2; cl00949
297246006608	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
297246006609	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
297246006610	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246006611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246006612	active site
297246006613	phosphorylation site [posttranslational modification]
297246006614	intermolecular recognition site; other site
297246006615	dimerization interface [polypeptide binding]; other site
297246006616	PAS domain S-box; Region: sensory_box; TIGR00229
297246006617	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
297246006618	putative active site [active]
297246006619	heme pocket [chemical binding]; other site
297246006620	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
297246006621	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246006622	dimer interface [polypeptide binding]; other site
297246006623	phosphorylation site [posttranslational modification]
297246006624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246006625	ATP binding site [chemical binding]; other site
297246006626	Mg2+ binding site [ion binding]; other site
297246006627	G-X-G motif; other site
297246006628	Heme NO binding; Region: HNOB; cl15268
297246006629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
297246006630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246006632	putative substrate translocation pore; other site
297246006633	Cupin domain; Region: Cupin_2; cl09118
297246006634	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
297246006635	nickel binding site [ion binding]; other site
297246006636	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
297246006637	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
297246006638	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
297246006639	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
297246006640	FAD binding pocket [chemical binding]; other site
297246006641	FAD binding motif [chemical binding]; other site
297246006642	phosphate binding motif [ion binding]; other site
297246006643	beta-alpha-beta structure motif; other site
297246006644	NAD binding pocket [chemical binding]; other site
297246006645	Iron coordination center [ion binding]; other site
297246006646	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
297246006647	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
297246006648	dimerization interface [polypeptide binding]; other site
297246006649	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
297246006650	ATP binding site [chemical binding]; other site
297246006651	Hydrogenase formation hypA family; Region: HypD; cl12072
297246006652	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
297246006653	HupF/HypC family; Region: HupF_HypC; cl00394
297246006654	Acylphosphatase; Region: Acylphosphatase; cl00551
297246006655	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
297246006656	HypF finger; Region: zf-HYPF; pfam07503
297246006657	HypF finger; Region: zf-HYPF; pfam07503
297246006658	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
297246006659	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246006660	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
297246006661	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
297246006662	High-affinity nickel-transport protein; Region: NicO; cl00964
297246006663	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
297246006664	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
297246006665	Ligand binding site; other site
297246006666	Putative Catalytic site; other site
297246006667	DXD motif; other site
297246006668	YdjC-like protein; Region: YdjC; cl01344
297246006669	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
297246006670	EamA-like transporter family; Region: EamA; cl01037
297246006671	EamA-like transporter family; Region: EamA; cl01037
297246006672	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246006673	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
297246006674	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
297246006675	active site
297246006676	dimerization interface [polypeptide binding]; other site
297246006677	TPR repeat; Region: TPR_11; pfam13414
297246006678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246006679	binding surface
297246006680	TPR motif; other site
297246006681	TPR repeat; Region: TPR_11; pfam13414
297246006682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246006683	binding surface
297246006684	TPR repeat; Region: TPR_11; pfam13414
297246006685	TPR motif; other site
297246006686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246006687	TPR motif; other site
297246006688	TPR repeat; Region: TPR_11; pfam13414
297246006689	binding surface
297246006690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246006691	binding surface
297246006692	TPR repeat; Region: TPR_11; pfam13414
297246006693	TPR motif; other site
297246006694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
297246006695	binding surface
297246006696	TPR motif; other site
297246006697	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
297246006698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006700	S-adenosylmethionine binding site [chemical binding]; other site
297246006701	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
297246006702	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
297246006703	active site
297246006704	substrate binding site [chemical binding]; other site
297246006705	metal binding site [ion binding]; metal-binding site
297246006706	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
297246006707	trimer interface [polypeptide binding]; other site
297246006708	active site
297246006709	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
297246006710	Flavoprotein; Region: Flavoprotein; cl08021
297246006711	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
297246006712	hypothetical protein; Reviewed; Region: PRK00024
297246006713	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
297246006714	MPN+ (JAMM) motif; other site
297246006715	Zinc-binding site [ion binding]; other site
297246006716	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246006717	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246006718	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
297246006719	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
297246006720	FOG: CBS domain [General function prediction only]; Region: COG0517
297246006721	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
297246006722	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
297246006723	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
297246006724	putative NAD(P) binding site [chemical binding]; other site
297246006725	putative substrate binding site [chemical binding]; other site
297246006726	catalytic Zn binding site [ion binding]; other site
297246006727	structural Zn binding site [ion binding]; other site
297246006728	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
297246006729	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
297246006730	putative dimer interface [polypeptide binding]; other site
297246006731	Putative cyclase; Region: Cyclase; cl00814
297246006732	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
297246006733	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
297246006734	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
297246006735	Thiamine pyrophosphokinase; Region: TPK; cd07995
297246006736	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
297246006737	active site
297246006738	dimerization interface [polypeptide binding]; other site
297246006739	thiamine binding site [chemical binding]; other site
297246006740	PQ loop repeat; Region: PQ-loop; cl12056
297246006741	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
297246006742	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
297246006743	active site clefts [active]
297246006744	zinc binding site [ion binding]; other site
297246006745	dimer interface [polypeptide binding]; other site
297246006746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006747	Major Facilitator Superfamily; Region: MFS_1; pfam07690
297246006748	putative substrate translocation pore; other site
297246006749	acyltransferase PapA5; Provisional; Region: PRK09294
297246006750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
297246006751	dimer interface [polypeptide binding]; other site
297246006752	phosphorylation site [posttranslational modification]
297246006753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246006754	ATP binding site [chemical binding]; other site
297246006755	Mg2+ binding site [ion binding]; other site
297246006756	G-X-G motif; other site
297246006757	Dot/Icm substrate protein; Region: SidE; pfam12252
297246006758	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
297246006759	Protein export membrane protein; Region: SecD_SecF; cl14618
297246006760	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246006761	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246006762	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246006763	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
297246006764	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
297246006765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006766	D-galactonate transporter; Region: 2A0114; TIGR00893
297246006767	putative substrate translocation pore; other site
297246006768	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
297246006769	Helix-turn-helix domains; Region: HTH; cl00088
297246006770	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
297246006771	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
297246006772	dimer interface [polypeptide binding]; other site
297246006773	active site
297246006774	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
297246006775	substrate binding site [chemical binding]; other site
297246006776	catalytic residue [active]
297246006777	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
297246006778	active site
297246006779	catalytic site [active]
297246006780	NeuB family; Region: NeuB; cl00496
297246006781	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
297246006782	Prephenate dehydratase; Region: PDT; pfam00800
297246006783	Chorismate mutase type II; Region: CM_2; cl00693
297246006784	aspartate aminotransferase; Provisional; Region: PRK05764
297246006785	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
297246006786	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246006787	homodimer interface [polypeptide binding]; other site
297246006788	catalytic residue [active]
297246006789	tellurite resistance protein TehB; Provisional; Region: PRK12335
297246006790	Domain of unknown function (DUF1971); Region: DUF1971; cl01451
297246006791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006792	S-adenosylmethionine binding site [chemical binding]; other site
297246006793	Helix-turn-helix domains; Region: HTH; cl00088
297246006794	Rrf2 family protein; Region: rrf2_super; TIGR00738
297246006795	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
297246006796	apolar tunnel; other site
297246006797	heme binding site [chemical binding]; other site
297246006798	dimerization interface [polypeptide binding]; other site
297246006799	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
297246006800	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
297246006801	catalytic loop [active]
297246006802	iron binding site [ion binding]; other site
297246006803	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
297246006804	FAD binding pocket [chemical binding]; other site
297246006805	FAD binding motif [chemical binding]; other site
297246006806	phosphate binding motif [ion binding]; other site
297246006807	beta-alpha-beta structure motif; other site
297246006808	NAD binding pocket [chemical binding]; other site
297246006809	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
297246006810	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
297246006811	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
297246006812	MltA specific insert domain; Region: MltA; cl08398
297246006813	3D domain; Region: 3D; cl01439
297246006814	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
297246006815	dimer interface [polypeptide binding]; other site
297246006816	putative tRNA-binding site [nucleotide binding]; other site
297246006817	EamA-like transporter family; Region: EamA; cl01037
297246006818	EamA-like transporter family; Region: EamA; cl01037
297246006819	Helix-turn-helix domain; Region: HTH_18; pfam12833
297246006820	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
297246006821	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
297246006822	putative active site pocket [active]
297246006823	dimerization interface [polypeptide binding]; other site
297246006824	putative catalytic residue [active]
297246006825	EamA-like transporter family; Region: EamA; cl01037
297246006826	EamA-like transporter family; Region: EamA; cl01037
297246006827	regulatory protein UhpC; Provisional; Region: PRK11663
297246006828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006829	putative substrate translocation pore; other site
297246006830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246006831	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
297246006832	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
297246006833	active site
297246006834	motif I; other site
297246006835	motif II; other site
297246006836	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
297246006837	Catalytic domain of Protein Kinases; Region: PKc; cd00180
297246006838	active site
297246006839	ATP binding site [chemical binding]; other site
297246006840	substrate binding site [chemical binding]; other site
297246006841	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246006842	substrate binding site [chemical binding]; other site
297246006843	activation loop (A-loop); other site
297246006844	activation loop (A-loop); other site
297246006845	PAS fold; Region: PAS_4; pfam08448
297246006846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246006847	DNA binding residues [nucleotide binding]
297246006848	dimerization interface [polypeptide binding]; other site
297246006849	Protein of unknown function, DUF488; Region: DUF488; cl01246
297246006850	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
297246006851	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
297246006852	active site
297246006853	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
297246006854	tetramer interface [polypeptide binding]; other site
297246006855	TPP-binding site [chemical binding]; other site
297246006856	heterodimer interface [polypeptide binding]; other site
297246006857	phosphorylation loop region [posttranslational modification]
297246006858	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
297246006859	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
297246006860	PYR/PP interface [polypeptide binding]; other site
297246006861	dimer interface [polypeptide binding]; other site
297246006862	TPP binding site [chemical binding]; other site
297246006863	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
297246006864	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
297246006865	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
297246006866	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
297246006867	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
297246006868	active site
297246006869	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
297246006870	active site
297246006871	catalytic triad [active]
297246006872	oxyanion hole [active]
297246006873	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
297246006874	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
297246006875	active site
297246006876	metal binding site [ion binding]; metal-binding site
297246006877	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
297246006878	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
297246006879	ParB-like nuclease domain; Region: ParBc; cl02129
297246006880	ParB-like partition proteins; Region: parB_part; TIGR00180
297246006881	16S rRNA methyltransferase B; Provisional; Region: PRK10901
297246006882	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
297246006883	putative RNA binding site [nucleotide binding]; other site
297246006884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246006885	S-adenosylmethionine binding site [chemical binding]; other site
297246006886	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
297246006887	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
297246006888	putative active site [active]
297246006889	substrate binding site [chemical binding]; other site
297246006890	putative cosubstrate binding site; other site
297246006891	catalytic site [active]
297246006892	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
297246006893	substrate binding site [chemical binding]; other site
297246006894	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
297246006895	active site
297246006896	catalytic residues [active]
297246006897	metal binding site [ion binding]; metal-binding site
297246006898	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
297246006899	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246006900	putative peptidoglycan binding site; other site
297246006901	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
297246006902	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
297246006903	Protein of unknown function (DUF494); Region: DUF494; cl01103
297246006904	DNA topoisomerase I; Validated; Region: PRK06599
297246006905	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
297246006906	active site
297246006907	interdomain interaction site; other site
297246006908	putative metal-binding site [ion binding]; other site
297246006909	nucleotide binding site [chemical binding]; other site
297246006910	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
297246006911	domain I; other site
297246006912	DNA binding groove [nucleotide binding]
297246006913	phosphate binding site [ion binding]; other site
297246006914	domain II; other site
297246006915	domain III; other site
297246006916	nucleotide binding site [chemical binding]; other site
297246006917	catalytic site [active]
297246006918	domain IV; other site
297246006919	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
297246006920	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
297246006921	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
297246006922	OpgC protein; Region: OpgC_C; cl00792
297246006923	Acyltransferase family; Region: Acyl_transf_3; pfam01757
297246006924	Bacterial PH domain; Region: DUF304; cl01348
297246006925	Protein of unknown function (DUF721); Region: DUF721; cl02324
297246006926	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246006927	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
297246006928	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246006929	Uncharacterized conserved protein [Function unknown]; Region: COG4278
297246006930	TIGR03442 family protein; Region: TIGR03442
297246006931	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
297246006932	putative active site [active]
297246006933	putative dimer interface [polypeptide binding]; other site
297246006934	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
297246006935	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
297246006936	active site
297246006937	Zn binding site [ion binding]; other site
297246006938	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
297246006939	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
297246006940	cell division protein FtsZ; Validated; Region: PRK09330
297246006941	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
297246006942	nucleotide binding site [chemical binding]; other site
297246006943	SulA interaction site; other site
297246006944	cell division protein FtsA; Region: ftsA; TIGR01174
297246006945	Cell division protein FtsA; Region: FtsA; cl11496
297246006946	Cell division protein FtsA; Region: FtsA; cl11496
297246006947	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
297246006948	Cell division protein FtsQ; Region: FtsQ; pfam03799
297246006949	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
297246006950	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
297246006951	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246006952	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
297246006953	FAD binding domain; Region: FAD_binding_4; pfam01565
297246006954	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
297246006955	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
297246006956	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
297246006957	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
297246006958	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246006959	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
297246006960	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
297246006961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246006962	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
297246006963	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246006964	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
297246006965	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
297246006966	Mg++ binding site [ion binding]; other site
297246006967	putative catalytic motif [active]
297246006968	putative substrate binding site [chemical binding]; other site
297246006969	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
297246006970	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
297246006971	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
297246006972	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
297246006973	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
297246006974	FtsZ protein binding site [polypeptide binding]; other site
297246006975	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
297246006976	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
297246006977	Walker A/P-loop; other site
297246006978	ATP binding site [chemical binding]; other site
297246006979	Q-loop/lid; other site
297246006980	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
297246006981	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
297246006982	Q-loop/lid; other site
297246006983	ABC transporter signature motif; other site
297246006984	Walker B; other site
297246006985	D-loop; other site
297246006986	H-loop/switch region; other site
297246006987	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
297246006988	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
297246006989	active site
297246006990	Tim44-like domain; Region: Tim44; cl09208
297246006991	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
297246006992	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
297246006993	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
297246006994	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
297246006995	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
297246006996	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246006997	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
297246006998	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
297246006999	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246007000	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
297246007001	IMP binding site; other site
297246007002	dimer interface [polypeptide binding]; other site
297246007003	interdomain contacts; other site
297246007004	partial ornithine binding site; other site
297246007005	HI0933-like protein; Region: HI0933_like; pfam03486
297246007006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007008	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
297246007009	putative active site [active]
297246007010	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
297246007011	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
297246007012	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
297246007013	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
297246007014	multifunctional aminopeptidase A; Provisional; Region: PRK00913
297246007015	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
297246007016	interface (dimer of trimers) [polypeptide binding]; other site
297246007017	Substrate-binding/catalytic site; other site
297246007018	Zn-binding sites [ion binding]; other site
297246007019	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
297246007020	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
297246007021	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
297246007022	interface (dimer of trimers) [polypeptide binding]; other site
297246007023	Substrate-binding/catalytic site; other site
297246007024	Zn-binding sites [ion binding]; other site
297246007025	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
297246007026	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
297246007027	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246007028	Sel1 repeat; Region: Sel1; cl02723
297246007029	Sel1 repeat; Region: Sel1; cl02723
297246007030	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246007031	Sel1 repeat; Region: Sel1; cl02723
297246007032	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246007033	Sel1 repeat; Region: Sel1; cl02723
297246007034	Sel1 repeat; Region: Sel1; cl02723
297246007035	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
297246007036	Sel1 repeat; Region: Sel1; cl02723
297246007037	Sel1 repeat; Region: Sel1; cl02723
297246007038	Sel1 repeat; Region: Sel1; cl02723
297246007039	Sel1 repeat; Region: Sel1; cl02723
297246007040	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
297246007041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
297246007042	GAF domain; Region: GAF; cl15785
297246007043	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246007044	metal binding site [ion binding]; metal-binding site
297246007045	active site
297246007046	I-site; other site
297246007047	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
297246007048	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
297246007049	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
297246007050	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
297246007051	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
297246007052	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
297246007053	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
297246007054	GIY-YIG motif/motif A; other site
297246007055	active site
297246007056	catalytic site [active]
297246007057	putative DNA binding site [nucleotide binding]; other site
297246007058	metal binding site [ion binding]; metal-binding site
297246007059	UvrB/uvrC motif; Region: UVR; pfam02151
297246007060	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
297246007061	response regulator; Provisional; Region: PRK09483
297246007062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246007063	active site
297246007064	phosphorylation site [posttranslational modification]
297246007065	intermolecular recognition site; other site
297246007066	dimerization interface [polypeptide binding]; other site
297246007067	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
297246007068	DNA binding residues [nucleotide binding]
297246007069	dimerization interface [polypeptide binding]; other site
297246007070	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
297246007071	cofactor binding site; other site
297246007072	metal binding site [ion binding]; metal-binding site
297246007073	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
297246007074	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
297246007075	putative MPT binding site; other site
297246007076	GTPase CgtA; Reviewed; Region: obgE; PRK12299
297246007077	GTP1/OBG; Region: GTP1_OBG; pfam01018
297246007078	Obg GTPase; Region: Obg; cd01898
297246007079	G1 box; other site
297246007080	GTP/Mg2+ binding site [chemical binding]; other site
297246007081	Switch I region; other site
297246007082	G2 box; other site
297246007083	G3 box; other site
297246007084	Switch II region; other site
297246007085	G4 box; other site
297246007086	G5 box; other site
297246007087	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
297246007088	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
297246007089	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
297246007090	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
297246007091	5S rRNA interface [nucleotide binding]; other site
297246007092	CTC domain interface [polypeptide binding]; other site
297246007093	L16 interface [polypeptide binding]; other site
297246007094	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
297246007095	putative active site [active]
297246007096	catalytic residue [active]
297246007097	GTP-binding protein YchF; Reviewed; Region: PRK09601
297246007098	YchF GTPase; Region: YchF; cd01900
297246007099	G1 box; other site
297246007100	GTP/Mg2+ binding site [chemical binding]; other site
297246007101	Switch I region; other site
297246007102	G2 box; other site
297246007103	Switch II region; other site
297246007104	G3 box; other site
297246007105	G4 box; other site
297246007106	G5 box; other site
297246007107	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
297246007108	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
297246007109	metal binding site [ion binding]; metal-binding site
297246007110	active site
297246007111	I-site; other site
297246007112	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
297246007113	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
297246007114	substrate binding pocket [chemical binding]; other site
297246007115	chain length determination region; other site
297246007116	substrate-Mg2+ binding site; other site
297246007117	catalytic residues [active]
297246007118	aspartate-rich region 1; other site
297246007119	active site lid residues [active]
297246007120	aspartate-rich region 2; other site
297246007121	Helix-turn-helix domains; Region: HTH; cl00088
297246007122	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
297246007123	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
297246007124	G1 box; other site
297246007125	GTP/Mg2+ binding site [chemical binding]; other site
297246007126	Switch I region; other site
297246007127	G2 box; other site
297246007128	G3 box; other site
297246007129	Switch II region; other site
297246007130	G4 box; other site
297246007131	G5 box; other site
297246007132	Nucleoside recognition; Region: Gate; cl00486
297246007133	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
297246007134	Nucleoside recognition; Region: Gate; cl00486
297246007135	FeoA domain; Region: FeoA; cl00838
297246007136	Predicted ATPase [General function prediction only]; Region: COG1485
297246007137	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007138	Walker A motif; other site
297246007139	ATP binding site [chemical binding]; other site
297246007140	Walker B motif; other site
297246007141	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
297246007142	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
297246007143	oligomerization interface [polypeptide binding]; other site
297246007144	active site
297246007145	metal binding site [ion binding]; metal-binding site
297246007146	pantoate--beta-alanine ligase; Region: panC; TIGR00018
297246007147	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
297246007148	active site
297246007149	nucleotide binding site [chemical binding]; other site
297246007150	HIGH motif; other site
297246007151	KMSKS motif; other site
297246007152	AAA domain; Region: AAA_28; pfam13521
297246007153	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007154	pyruvate carboxylase subunit A; Validated; Region: PRK07178
297246007155	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
297246007156	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246007157	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
297246007158	Dienelactone hydrolase family; Region: DLH; pfam01738
297246007159	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
297246007160	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
297246007161	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
297246007162	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
297246007163	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
297246007164	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
297246007165	DNA binding residues [nucleotide binding]
297246007166	FtsX-like permease family; Region: FtsX; cl15850
297246007167	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
297246007168	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
297246007169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007170	Walker A/P-loop; other site
297246007171	ATP binding site [chemical binding]; other site
297246007172	Q-loop/lid; other site
297246007173	ABC transporter signature motif; other site
297246007174	Walker B; other site
297246007175	D-loop; other site
297246007176	H-loop/switch region; other site
297246007177	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
297246007178	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
297246007179	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
297246007180	P loop; other site
297246007181	GTP binding site [chemical binding]; other site
297246007182	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
297246007183	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
297246007184	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
297246007185	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
297246007186	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
297246007187	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
297246007188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007189	S-adenosylmethionine binding site [chemical binding]; other site
297246007190	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
297246007191	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007192	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007193	Walker A/P-loop; other site
297246007194	Walker A motif; other site
297246007195	ATP binding site [chemical binding]; other site
297246007196	ATP binding site [chemical binding]; other site
297246007197	Walker B motif; other site
297246007198	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
297246007199	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
297246007200	putative active site [active]
297246007201	putative metal binding site [ion binding]; other site
297246007202	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
297246007203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246007204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007205	S-adenosylmethionine binding site [chemical binding]; other site
297246007206	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
297246007207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007208	ATP-grasp domain; Region: ATP-grasp_4; cl03087
297246007209	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
297246007210	active site
297246007211	catalytic residues [active]
297246007212	metal binding site [ion binding]; metal-binding site
297246007213	tartrate dehydrogenase; Provisional; Region: PRK08194
297246007214	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
297246007215	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
297246007216	Dienelactone hydrolase family; Region: DLH; pfam01738
297246007217	tricarballylate utilization protein B; Provisional; Region: PRK15033
297246007218	Phagosome trafficking protein DotA; Region: DotA; pfam11388
297246007219	putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539
297246007220	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
297246007221	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
297246007222	metal-binding site [ion binding]
297246007223	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
297246007224	Methyltransferase domain; Region: Methyltransf_31; pfam13847
297246007225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007226	S-adenosylmethionine binding site [chemical binding]; other site
297246007227	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
297246007228	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
297246007229	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
297246007230	putative active site [active]
297246007231	Zinc-finger domain; Region: zf-CHCC; cl01821
297246007232	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007233	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
297246007234	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
297246007235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246007236	ATP binding site [chemical binding]; other site
297246007237	Mg2+ binding site [ion binding]; other site
297246007238	G-X-G motif; other site
297246007239	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
297246007240	ATP binding site [chemical binding]; other site
297246007241	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
297246007242	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
297246007243	AMIN domain; Region: AMIN; pfam11741
297246007244	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
297246007245	active site
297246007246	metal binding site [ion binding]; metal-binding site
297246007247	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
297246007248	putative peptidoglycan binding site; other site
297246007249	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
297246007250	putative carbohydrate kinase; Provisional; Region: PRK10565
297246007251	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
297246007252	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
297246007253	putative substrate binding site [chemical binding]; other site
297246007254	putative ATP binding site [chemical binding]; other site
297246007255	Stringent starvation protein B; Region: SspB; cl01120
297246007256	stringent starvation protein A; Provisional; Region: sspA; PRK09481
297246007257	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
297246007258	C-terminal domain interface [polypeptide binding]; other site
297246007259	putative GSH binding site (G-site) [chemical binding]; other site
297246007260	dimer interface [polypeptide binding]; other site
297246007261	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
297246007262	dimer interface [polypeptide binding]; other site
297246007263	N-terminal domain interface [polypeptide binding]; other site
297246007264	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
297246007265	cytochrome b; Provisional; Region: CYTB; MTH00145
297246007266	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
297246007267	Qi binding site; other site
297246007268	intrachain domain interface; other site
297246007269	interchain domain interface [polypeptide binding]; other site
297246007270	heme bH binding site [chemical binding]; other site
297246007271	heme bL binding site [chemical binding]; other site
297246007272	Qo binding site; other site
297246007273	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
297246007274	interchain domain interface [polypeptide binding]; other site
297246007275	intrachain domain interface; other site
297246007276	Qi binding site; other site
297246007277	Qo binding site; other site
297246007278	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
297246007279	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
297246007280	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
297246007281	[2Fe-2S] cluster binding site [ion binding]; other site
297246007282	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
297246007283	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
297246007284	23S rRNA interface [nucleotide binding]; other site
297246007285	L3 interface [polypeptide binding]; other site
297246007286	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
297246007287	dimer interface [polypeptide binding]; other site
297246007288	[2Fe-2S] cluster binding site [ion binding]; other site
297246007289	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
297246007290	IHF dimer interface [polypeptide binding]; other site
297246007291	IHF - DNA interface [nucleotide binding]; other site
297246007292	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
297246007293	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
297246007294	putative tRNA-binding site [nucleotide binding]; other site
297246007295	B3/4 domain; Region: B3_4; cl11458
297246007296	tRNA synthetase B5 domain; Region: B5; cl08394
297246007297	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
297246007298	dimer interface [polypeptide binding]; other site
297246007299	motif 1; other site
297246007300	motif 3; other site
297246007301	motif 2; other site
297246007302	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
297246007303	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
297246007304	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
297246007305	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
297246007306	dimer interface [polypeptide binding]; other site
297246007307	motif 1; other site
297246007308	active site
297246007309	motif 2; other site
297246007310	motif 3; other site
297246007311	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
297246007312	23S rRNA binding site [nucleotide binding]; other site
297246007313	L21 binding site [polypeptide binding]; other site
297246007314	L13 binding site [polypeptide binding]; other site
297246007315	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
297246007316	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
297246007317	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
297246007318	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
297246007319	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
297246007320	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
297246007321	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
297246007322	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
297246007323	active site
297246007324	dimer interface [polypeptide binding]; other site
297246007325	motif 1; other site
297246007326	motif 2; other site
297246007327	motif 3; other site
297246007328	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
297246007329	anticodon binding site; other site
297246007330	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
297246007331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
297246007332	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
297246007333	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
297246007334	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246007335	ligand binding site [chemical binding]; other site
297246007336	flexible hinge region; other site
297246007337	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246007338	ligand binding site [chemical binding]; other site
297246007339	flexible hinge region; other site
297246007340	TIGR03442 family protein; Region: TIGR03442
297246007341	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
297246007342	putative active site [active]
297246007343	putative dimer interface [polypeptide binding]; other site
297246007344	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
297246007345	FMN binding site [chemical binding]; other site
297246007346	active site
297246007347	substrate binding site [chemical binding]; other site
297246007348	catalytic residue [active]
297246007349	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
297246007350	dimerization interface [polypeptide binding]; other site
297246007351	putative DNA binding site [nucleotide binding]; other site
297246007352	putative Zn2+ binding site [ion binding]; other site
297246007353	Predicted membrane protein [Function unknown]; Region: COG2860
297246007354	UPF0126 domain; Region: UPF0126; pfam03458
297246007355	UPF0126 domain; Region: UPF0126; pfam03458
297246007356	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
297246007357	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
297246007358	substrate binding site [chemical binding]; other site
297246007359	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
297246007360	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
297246007361	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
297246007362	Cytochrome c; Region: Cytochrom_C; cl11414
297246007363	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
297246007364	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
297246007365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
297246007366	catalytic residue [active]
297246007367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246007368	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
297246007369	active site
297246007370	phosphorylation site [posttranslational modification]
297246007371	intermolecular recognition site; other site
297246007372	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
297246007373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
297246007374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
297246007375	ATP binding site [chemical binding]; other site
297246007376	Mg2+ binding site [ion binding]; other site
297246007377	G-X-G motif; other site
297246007378	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
297246007379	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
297246007380	domain interfaces; other site
297246007381	active site
297246007382	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
297246007383	active site
297246007384	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
297246007385	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
297246007386	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
297246007387	HemY protein N-terminus; Region: HemY_N; pfam07219
297246007388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
297246007389	TPR motif; other site
297246007390	binding surface
297246007391	Cation efflux family; Region: Cation_efflux; cl00316
297246007392	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
297246007393	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
297246007394	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
297246007395	putative active site [active]
297246007396	putative substrate binding site [chemical binding]; other site
297246007397	catalytic site [active]
297246007398	dimer interface [polypeptide binding]; other site
297246007399	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
297246007400	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
297246007401	active site
297246007402	NTP binding site [chemical binding]; other site
297246007403	metal binding triad [ion binding]; metal-binding site
297246007404	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
297246007405	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
297246007406	GTPase RsgA; Reviewed; Region: PRK12288
297246007407	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
297246007408	RNA binding site [nucleotide binding]; other site
297246007409	homodimer interface [polypeptide binding]; other site
297246007410	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
297246007411	GTPase/Zn-binding domain interface [polypeptide binding]; other site
297246007412	GTP/Mg2+ binding site [chemical binding]; other site
297246007413	G4 box; other site
297246007414	G5 box; other site
297246007415	G1 box; other site
297246007416	Switch I region; other site
297246007417	G2 box; other site
297246007418	G3 box; other site
297246007419	Switch II region; other site
297246007420	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
297246007421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246007422	Walker A motif; other site
297246007423	ATP binding site [chemical binding]; other site
297246007424	Walker B motif; other site
297246007425	arginine finger; other site
297246007426	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
297246007427	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
297246007428	recombination protein RecR; Reviewed; Region: recR; PRK00076
297246007429	RecR protein; Region: RecR; pfam02132
297246007430	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
297246007431	putative active site [active]
297246007432	putative metal-binding site [ion binding]; other site
297246007433	tetramer interface [polypeptide binding]; other site
297246007434	Protein of unknown function, DUF547; Region: DUF547; pfam04784
297246007435	Sulfatase; Region: Sulfatase; cl10460
297246007436	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
297246007437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
297246007438	active site
297246007439	dimerization interface [polypeptide binding]; other site
297246007440	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
297246007441	DNA binding site [nucleotide binding]
297246007442	hypothetical protein; Provisional; Region: PRK11573
297246007443	Domain of unknown function DUF21; Region: DUF21; pfam01595
297246007444	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
297246007445	Transporter associated domain; Region: CorC_HlyC; cl08393
297246007446	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
297246007447	dimer interface [polypeptide binding]; other site
297246007448	substrate binding site [chemical binding]; other site
297246007449	metal binding sites [ion binding]; metal-binding site
297246007450	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
297246007451	nucleotide binding site/active site [active]
297246007452	HIT family signature motif; other site
297246007453	catalytic residue [active]
297246007454	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
297246007455	GTP cyclohydrolase I; Provisional; Region: PLN03044
297246007456	homodecamer interface [polypeptide binding]; other site
297246007457	active site
297246007458	putative catalytic site residues [active]
297246007459	zinc binding site [ion binding]; other site
297246007460	GTP-CH-I/GFRP interaction surface; other site
297246007461	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
297246007462	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
297246007463	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
297246007464	RNase E interface [polypeptide binding]; other site
297246007465	trimer interface [polypeptide binding]; other site
297246007466	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
297246007467	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
297246007468	RNase E interface [polypeptide binding]; other site
297246007469	trimer interface [polypeptide binding]; other site
297246007470	active site
297246007471	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
297246007472	putative nucleic acid binding region [nucleotide binding]; other site
297246007473	G-X-X-G motif; other site
297246007474	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
297246007475	RNA binding site [nucleotide binding]; other site
297246007476	domain interface; other site
297246007477	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
297246007478	16S/18S rRNA binding site [nucleotide binding]; other site
297246007479	S13e-L30e interaction site [polypeptide binding]; other site
297246007480	25S rRNA binding site [nucleotide binding]; other site
297246007481	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
297246007482	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
297246007483	RNA binding site [nucleotide binding]; other site
297246007484	active site
297246007485	Ribosome-binding factor A; Region: RBFA; cl00542
297246007486	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
297246007487	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
297246007488	translation initiation factor IF-2; Region: IF-2; TIGR00487
297246007489	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
297246007490	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
297246007491	G1 box; other site
297246007492	putative GEF interaction site [polypeptide binding]; other site
297246007493	GTP/Mg2+ binding site [chemical binding]; other site
297246007494	Switch I region; other site
297246007495	G2 box; other site
297246007496	G3 box; other site
297246007497	Switch II region; other site
297246007498	G4 box; other site
297246007499	G5 box; other site
297246007500	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
297246007501	Translation-initiation factor 2; Region: IF-2; pfam11987
297246007502	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
297246007503	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
297246007504	NusA N-terminal domain; Region: NusA_N; pfam08529
297246007505	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
297246007506	RNA binding site [nucleotide binding]; other site
297246007507	homodimer interface [polypeptide binding]; other site
297246007508	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
297246007509	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
297246007510	G-X-X-G motif; other site
297246007511	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
297246007512	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
297246007513	ribosome maturation protein RimP; Reviewed; Region: PRK00092
297246007514	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
297246007515	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
297246007516	Sm1 motif; other site
297246007517	D3 - B interaction site; other site
297246007518	D1 - D2 interaction site; other site
297246007519	Hfq - Hfq interaction site; other site
297246007520	RNA binding pocket [nucleotide binding]; other site
297246007521	Sm2 motif; other site
297246007522	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
297246007523	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
297246007524	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
297246007525	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
297246007526	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
297246007527	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
297246007528	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
297246007529	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
297246007530	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
297246007531	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
297246007532	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
297246007533	4Fe-4S binding domain; Region: Fer4; cl02805
297246007534	4Fe-4S binding domain; Region: Fer4; cl02805
297246007535	NADH dehydrogenase; Region: NADHdh; cl00469
297246007536	NADH dehydrogenase subunit G; Validated; Region: PRK09129
297246007537	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
297246007538	catalytic loop [active]
297246007539	iron binding site [ion binding]; other site
297246007540	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
297246007541	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
297246007542	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
297246007543	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
297246007544	SLBB domain; Region: SLBB; pfam10531
297246007545	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
297246007546	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
297246007547	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
297246007548	putative dimer interface [polypeptide binding]; other site
297246007549	[2Fe-2S] cluster binding site [ion binding]; other site
297246007550	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
297246007551	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
297246007552	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
297246007553	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
297246007554	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
297246007555	Preprotein translocase SecG subunit; Region: SecG; cl09123
297246007556	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
297246007557	substrate binding site [chemical binding]; other site
297246007558	dimer interface [polypeptide binding]; other site
297246007559	catalytic triad [active]
297246007560	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
297246007561	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
297246007562	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
297246007563	active site
297246007564	substrate binding site [chemical binding]; other site
297246007565	metal binding site [ion binding]; metal-binding site
297246007566	dihydropteroate synthase; Region: DHPS; TIGR01496
297246007567	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
297246007568	substrate binding pocket [chemical binding]; other site
297246007569	dimer interface [polypeptide binding]; other site
297246007570	inhibitor binding site; inhibition site
297246007571	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
297246007572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246007573	Walker A motif; other site
297246007574	ATP binding site [chemical binding]; other site
297246007575	Walker B motif; other site
297246007576	arginine finger; other site
297246007577	Peptidase family M41; Region: Peptidase_M41; pfam01434
297246007578	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
297246007579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007580	S-adenosylmethionine binding site [chemical binding]; other site
297246007581	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
297246007582	OpgC protein; Region: OpgC_C; cl00792
297246007583	Acyltransferase family; Region: Acyl_transf_3; pfam01757
297246007584	IucA / IucC family; Region: IucA_IucC; pfam04183
297246007585	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
297246007586	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
297246007587	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007588	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
297246007589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
297246007590	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
297246007591	CCC1-related family of proteins; Region: CCC1_like; cl00278
297246007592	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
297246007593	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
297246007594	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
297246007595	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
297246007596	shikimate binding site; other site
297246007597	NAD(P) binding site [chemical binding]; other site
297246007598	aminopeptidase N; Provisional; Region: pepN; PRK14015
297246007599	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
297246007600	active site
297246007601	Zn binding site [ion binding]; other site
297246007602	PrkA family serine protein kinase; Provisional; Region: PRK15455
297246007603	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
297246007604	Uncharacterized conserved protein [Function unknown]; Region: COG2718
297246007605	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
297246007606	SpoVR family protein; Provisional; Region: PRK11767
297246007607	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
297246007608	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
297246007609	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
297246007610	catalytic triad [active]
297246007611	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
297246007612	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
297246007613	inhibitor site; inhibition site
297246007614	active site
297246007615	dimer interface [polypeptide binding]; other site
297246007616	catalytic residue [active]
297246007617	Cupin domain; Region: Cupin_2; cl09118
297246007618	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
297246007619	Helix-turn-helix domains; Region: HTH; cl00088
297246007620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
297246007621	dimerization interface [polypeptide binding]; other site
297246007622	similar to resolvase (partial);hypothetical protein
297246007623	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
297246007624	active site
297246007625	metal binding site [ion binding]; metal-binding site
297246007626	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
297246007627	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007628	Family description; Region: UvrD_C_2; cl15862
297246007629	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
297246007630	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
297246007631	dimerization interface [polypeptide binding]; other site
297246007632	domain crossover interface; other site
297246007633	redox-dependent activation switch; other site
297246007634	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
297246007635	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
297246007636	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
297246007637	active site
297246007638	catalytic tetrad [active]
297246007639	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
297246007640	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
297246007641	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
297246007642	G1 box; other site
297246007643	putative GEF interaction site [polypeptide binding]; other site
297246007644	GTP/Mg2+ binding site [chemical binding]; other site
297246007645	Switch I region; other site
297246007646	G2 box; other site
297246007647	G3 box; other site
297246007648	Switch II region; other site
297246007649	G4 box; other site
297246007650	G5 box; other site
297246007651	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
297246007652	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
297246007653	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
297246007654	recombination and repair protein; Provisional; Region: PRK10869
297246007655	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
297246007656	Walker A/P-loop; other site
297246007657	ATP binding site [chemical binding]; other site
297246007658	Q-loop/lid; other site
297246007659	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
297246007660	ABC transporter signature motif; other site
297246007661	Walker B; other site
297246007662	D-loop; other site
297246007663	H-loop/switch region; other site
297246007664	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246007665	DNA-binding site [nucleotide binding]; DNA binding site
297246007666	RNA-binding motif; other site
297246007667	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246007668	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
297246007669	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246007670	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
297246007671	Amidinotransferase; Region: Amidinotransf; cl12043
297246007672	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
297246007673	substrate of the Legionella pneumophila Dot/Icm system, truncated C_terminal part
297246007674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
297246007675	Helix-turn-helix domains; Region: HTH; cl00088
297246007676	Integrase core domain; Region: rve; cl01316
297246007677	transposase/IS protein; Provisional; Region: PRK09183
297246007678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
297246007679	Walker A motif; other site
297246007680	ATP binding site [chemical binding]; other site
297246007681	Walker B motif; other site
297246007682	substrates of the Legionella pneumophila Dot/Icm system, truncated N_terminal part
297246007683	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348
297246007684	RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cl15348
297246007685	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
297246007686	active site
297246007687	nucleophile elbow; other site
297246007688	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
297246007689	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
297246007690	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
297246007691	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
297246007692	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
297246007693	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
297246007694	RNA binding site [nucleotide binding]; other site
297246007695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007696	S-adenosylmethionine binding site [chemical binding]; other site
297246007697	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
297246007698	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
297246007699	glutaminase active site [active]
297246007700	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
297246007701	dimer interface [polypeptide binding]; other site
297246007702	active site
297246007703	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
297246007704	dimer interface [polypeptide binding]; other site
297246007705	active site
297246007706	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
297246007707	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
297246007708	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
297246007709	active site
297246007710	oxyanion hole [active]
297246007711	catalytic triad [active]
297246007712	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
297246007713	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
297246007714	GIY-YIG motif/motif A; other site
297246007715	putative active site [active]
297246007716	putative metal binding site [ion binding]; other site
297246007717	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
297246007718	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
297246007719	active site residue [active]
297246007720	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
297246007721	SmpB-tmRNA interface; other site
297246007722	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
297246007723	catalytic triad [active]
297246007724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
297246007725	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
297246007726	putative substrate translocation pore; other site
297246007727	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
297246007728	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
297246007729	putative active site [active]
297246007730	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007731	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
297246007732	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
297246007733	active site
297246007734	Esterase/lipase [General function prediction only]; Region: COG1647
297246007735	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
297246007736	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
297246007737	B1 nucleotide binding pocket [chemical binding]; other site
297246007738	B2 nucleotide binding pocket [chemical binding]; other site
297246007739	CAS motifs; other site
297246007740	active site
297246007741	TPR repeat; Region: TPR_11; pfam13414
297246007742	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
297246007743	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
297246007744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007745	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
297246007746	DNA-binding site [nucleotide binding]; DNA binding site
297246007747	RNA-binding motif; other site
297246007748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007749	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
297246007750	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
297246007751	Amidase; Region: Amidase; cl11426
297246007752	Oxygen tolerance; Region: BatD; pfam13584
297246007753	Tetratricopeptide repeat; Region: TPR_16; pfam13432
297246007754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
297246007755	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
297246007756	metal ion-dependent adhesion site (MIDAS); other site
297246007757	Aerotolerance regulator N-terminal; Region: BatA; cl06567
297246007758	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
297246007759	metal ion-dependent adhesion site (MIDAS); other site
297246007760	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
297246007761	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
297246007762	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
297246007763	MoxR-like ATPases [General function prediction only]; Region: COG0714
297246007764	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007765	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
297246007766	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
297246007767	FMN binding site [chemical binding]; other site
297246007768	active site
297246007769	catalytic residues [active]
297246007770	substrate binding site [chemical binding]; other site
297246007771	pteridine reductase; Provisional; Region: PRK09135
297246007772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007773	NAD(P) binding site [chemical binding]; other site
297246007774	active site
297246007775	Uncharacterized conserved protein [Function unknown]; Region: COG1565
297246007776	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
297246007777	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
297246007778	primosome assembly protein PriA; Validated; Region: PRK05580
297246007779	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
297246007780	ATP binding site [chemical binding]; other site
297246007781	putative Mg++ binding site [ion binding]; other site
297246007782	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246007783	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
297246007784	active site
297246007785	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
297246007786	dimerization interface [polypeptide binding]; other site
297246007787	active site
297246007788	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
297246007789	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
297246007790	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
297246007791	GAF domain; Region: GAF; cl00853
297246007792	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
297246007793	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
297246007794	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
297246007795	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
297246007796	putative active site [active]
297246007797	Ap4A binding site [chemical binding]; other site
297246007798	nudix motif; other site
297246007799	putative metal binding site [ion binding]; other site
297246007800	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
297246007801	active site
297246007802	homodimer interface [polypeptide binding]; other site
297246007803	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
297246007804	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
297246007805	Substrate binding site; other site
297246007806	Mg++ binding site; other site
297246007807	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
297246007808	active site
297246007809	substrate binding site [chemical binding]; other site
297246007810	CoA binding site [chemical binding]; other site
297246007811	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
297246007812	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
297246007813	transmembrane helices; other site
297246007814	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
297246007815	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
297246007816	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
297246007817	endonuclease III; Provisional; Region: PRK10702
297246007818	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
297246007819	minor groove reading motif; other site
297246007820	helix-hairpin-helix signature motif; other site
297246007821	substrate binding pocket [chemical binding]; other site
297246007822	active site
297246007823	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
297246007824	ferredoxin; Provisional; Region: PRK06991
297246007825	Putative Fe-S cluster; Region: FeS; pfam04060
297246007826	4Fe-4S binding domain; Region: Fer4; cl02805
297246007827	4Fe-4S binding domain; Region: Fer4; cl02805
297246007828	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
297246007829	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
297246007830	active site
297246007831	HIGH motif; other site
297246007832	KMSKS motif; other site
297246007833	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
297246007834	tRNA binding surface [nucleotide binding]; other site
297246007835	anticodon binding site; other site
297246007836	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
297246007837	dimer interface [polypeptide binding]; other site
297246007838	putative tRNA-binding site [nucleotide binding]; other site
297246007839	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
297246007840	Flavoprotein; Region: Flavoprotein; cl08021
297246007841	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
297246007842	Ligand Binding Site [chemical binding]; other site
297246007843	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
297246007844	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
297246007845	Substrate binding site; other site
297246007846	Cupin domain; Region: Cupin_2; cl09118
297246007847	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
297246007848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007850	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
297246007851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246007852	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
297246007853	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
297246007854	P-loop; other site
297246007855	Magnesium ion binding site [ion binding]; other site
297246007856	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
297246007857	Magnesium ion binding site [ion binding]; other site
297246007858	ParB-like partition proteins; Region: parB_part; TIGR00180
297246007859	ParB-like nuclease domain; Region: ParBc; cl02129
297246007860	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
297246007861	putative active site [active]
297246007862	Transposase domain (DUF772); Region: DUF772; cl15789
297246007863	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
297246007864	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246007865	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
297246007866	Subunit III/VIIa interface [polypeptide binding]; other site
297246007867	Phospholipid binding site [chemical binding]; other site
297246007868	Subunit I/III interface [polypeptide binding]; other site
297246007869	Subunit III/VIb interface [polypeptide binding]; other site
297246007870	Subunit III/VIa interface; other site
297246007871	Subunit III/Vb interface [polypeptide binding]; other site
297246007872	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
297246007873	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
297246007874	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
297246007875	Subunit I/III interface [polypeptide binding]; other site
297246007876	D-pathway; other site
297246007877	Subunit I/VIIc interface [polypeptide binding]; other site
297246007878	Subunit I/IV interface [polypeptide binding]; other site
297246007879	Subunit I/II interface [polypeptide binding]; other site
297246007880	Low-spin heme (heme a) binding site [chemical binding]; other site
297246007881	Subunit I/VIIa interface [polypeptide binding]; other site
297246007882	Subunit I/VIa interface [polypeptide binding]; other site
297246007883	Dimer interface; other site
297246007884	Putative water exit pathway; other site
297246007885	Binuclear center (heme a3/CuB) [ion binding]; other site
297246007886	K-pathway; other site
297246007887	Subunit I/Vb interface [polypeptide binding]; other site
297246007888	Putative proton exit pathway; other site
297246007889	Subunit I/VIb interface; other site
297246007890	Subunit I/VIc interface [polypeptide binding]; other site
297246007891	Electron transfer pathway; other site
297246007892	Subunit I/VIIIb interface [polypeptide binding]; other site
297246007893	Subunit I/VIIb interface [polypeptide binding]; other site
297246007894	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
297246007895	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
297246007896	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
297246007897	Cytochrome c; Region: Cytochrom_C; cl11414
297246007898	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
297246007899	Cytochrome c; Region: Cytochrom_C; cl11414
297246007900	Cytochrome c; Region: Cytochrom_C; cl11414
297246007901	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
297246007902	iron-sulfur cluster [ion binding]; other site
297246007903	[2Fe-2S] cluster binding site [ion binding]; other site
297246007904	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
297246007905	LysE type translocator; Region: LysE; cl00565
297246007906	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
297246007907	active site
297246007908	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
297246007909	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
297246007910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246007911	S-adenosylmethionine binding site [chemical binding]; other site
297246007912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
297246007913	SCP-2 sterol transfer family; Region: SCP2; cl01225
297246007914	SCP-2 sterol transfer family; Region: SCP2; cl01225
297246007915	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
297246007916	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246007917	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
297246007918	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
297246007919	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
297246007920	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
297246007921	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
297246007922	tyramine oxidase; Provisional; Region: tynA; PRK11504
297246007923	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
297246007924	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
297246007925	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
297246007926	Mitochondrial carrier protein; Region: Mito_carr; pfam00153
297246007927	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
297246007928	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
297246007929	Transglycosylase SLT domain; Region: SLT_2; pfam13406
297246007930	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
297246007931	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
297246007932	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
297246007933	FtsX-like permease family; Region: FtsX; cl15850
297246007934	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
297246007935	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
297246007936	Walker A/P-loop; other site
297246007937	ATP binding site [chemical binding]; other site
297246007938	Q-loop/lid; other site
297246007939	ABC transporter signature motif; other site
297246007940	Walker B; other site
297246007941	D-loop; other site
297246007942	H-loop/switch region; other site
297246007943	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
297246007944	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246007945	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
297246007946	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
297246007947	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
297246007948	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
297246007949	active site
297246007950	metal binding site [ion binding]; metal-binding site
297246007951	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
297246007952	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
297246007953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007954	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
297246007955	tetramerization interface [polypeptide binding]; other site
297246007956	active site
297246007957	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
297246007958	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
297246007959	FMN reductase; Validated; Region: fre; PRK08051
297246007960	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
297246007961	FAD binding pocket [chemical binding]; other site
297246007962	FAD binding motif [chemical binding]; other site
297246007963	phosphate binding motif [ion binding]; other site
297246007964	beta-alpha-beta structure motif; other site
297246007965	NAD binding pocket [chemical binding]; other site
297246007966	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
297246007967	transcription termination factor Rho; Provisional; Region: rho; PRK09376
297246007968	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
297246007969	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
297246007970	RNA binding site [nucleotide binding]; other site
297246007971	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
297246007972	multimer interface [polypeptide binding]; other site
297246007973	Walker A motif; other site
297246007974	ATP binding site [chemical binding]; other site
297246007975	Walker B motif; other site
297246007976	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
297246007977	catalytic residues [active]
297246007978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
297246007979	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
297246007980	fumarate hydratase; Reviewed; Region: fumC; PRK00485
297246007981	Class II fumarases; Region: Fumarase_classII; cd01362
297246007982	active site
297246007983	tetramer interface [polypeptide binding]; other site
297246007984	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
297246007985	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
297246007986	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
297246007987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246007988	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
297246007989	putative acyl-acceptor binding pocket; other site
297246007990	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
297246007991	putative acyl-acceptor binding pocket; other site
297246007992	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
297246007993	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
297246007994	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
297246007995	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
297246007996	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
297246007997	trimer interface [polypeptide binding]; other site
297246007998	active site
297246007999	UDP-GlcNAc binding site [chemical binding]; other site
297246008000	lipid binding site [chemical binding]; lipid-binding site
297246008001	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
297246008002	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
297246008003	active site
297246008004	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
297246008005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
297246008006	S-adenosylmethionine binding site [chemical binding]; other site
297246008007	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
297246008008	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
297246008009	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
297246008010	dimer interface [polypeptide binding]; other site
297246008011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246008012	catalytic residue [active]
297246008013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
297246008014	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
297246008015	IHF dimer interface [polypeptide binding]; other site
297246008016	IHF - DNA interface [nucleotide binding]; other site
297246008017	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
297246008018	trimer interface [polypeptide binding]; other site
297246008019	active site
297246008020	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
297246008021	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
297246008022	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
297246008023	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
297246008024	dimer interface [polypeptide binding]; other site
297246008025	active site residues [active]
297246008026	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
297246008027	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
297246008028	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
297246008029	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
297246008030	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
297246008031	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
297246008032	ligand binding site [chemical binding]; other site
297246008033	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
297246008034	active site
297246008035	substrate binding pocket [chemical binding]; other site
297246008036	dimer interface [polypeptide binding]; other site
297246008037	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
297246008038	dimer interface [polypeptide binding]; other site
297246008039	putative active site [active]
297246008040	putative substrate binding site [chemical binding]; other site
297246008041	catalytic site [active]
297246008042	peroxidase; Provisional; Region: PRK15000
297246008043	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
297246008044	dimer interface [polypeptide binding]; other site
297246008045	decamer (pentamer of dimers) interface [polypeptide binding]; other site
297246008046	catalytic triad [active]
297246008047	peroxidatic and resolving cysteines [active]
297246008048	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
297246008049	putative GSH binding site [chemical binding]; other site
297246008050	catalytic residues [active]
297246008051	superoxide dismutase; Provisional; Region: PRK10543
297246008052	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
297246008053	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
297246008054	acetylornithine aminotransferase; Provisional; Region: PRK02627
297246008055	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
297246008056	inhibitor-cofactor binding pocket; inhibition site
297246008057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
297246008058	catalytic residue [active]
297246008059	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
297246008060	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
297246008061	active site
297246008062	catalytic site [active]
297246008063	malate dehydrogenase; Provisional; Region: PRK13529
297246008064	Malic enzyme, N-terminal domain; Region: malic; pfam00390
297246008065	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
297246008066	NAD(P) binding site [chemical binding]; other site
297246008067	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
297246008068	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
297246008069	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
297246008070	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
297246008071	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
297246008072	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
297246008073	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
297246008074	active site
297246008075	Zn binding site [ion binding]; other site
297246008076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
297246008077	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
297246008078	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
297246008079	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
297246008080	CAP-like domain; other site
297246008081	active site
297246008082	primary dimer interface [polypeptide binding]; other site
297246008083	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
297246008084	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
297246008085	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
297246008086	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
297246008087	alpha subunit interaction interface [polypeptide binding]; other site
297246008088	Walker A motif; other site
297246008089	ATP binding site [chemical binding]; other site
297246008090	Walker B motif; other site
297246008091	inhibitor binding site; inhibition site
297246008092	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
297246008093	ATP synthase; Region: ATP-synt; cl00365
297246008094	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
297246008095	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
297246008096	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
297246008097	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
297246008098	beta subunit interaction interface [polypeptide binding]; other site
297246008099	Walker A motif; other site
297246008100	ATP binding site [chemical binding]; other site
297246008101	Walker B motif; other site
297246008102	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
297246008103	Plant ATP synthase F0; Region: YMF19; cl07975
297246008104	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
297246008105	Plant ATP synthase F0; Region: YMF19; cl07975
297246008106	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
297246008107	ATP synthase subunit C; Region: ATP-synt_C; cl00466
297246008108	ATP synthase A chain; Region: ATP-synt_A; cl00413
297246008109	ATP synthase I chain; Region: ATP_synt_I; cl09170
297246008110	outer membrane lipoprotein; Provisional; Region: PRK11023
297246008111	BON domain; Region: BON; cl02771
297246008112	outer membrane lipoprotein; Provisional; Region: PRK11023
297246008113	BON domain; Region: BON; cl02771
297246008114	BON domain; Region: BON; cl02771
297246008115	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
297246008116	dimer interface [polypeptide binding]; other site
297246008117	active site
297246008118	Restriction endonuclease; Region: Mrr_cat; cl00516
297246008119	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
297246008120	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
297246008121	putative ligand binding site [chemical binding]; other site
297246008122	Predicted methyltransferases [General function prediction only]; Region: COG0313
297246008123	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
297246008124	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
297246008125	Di-iron ligands [ion binding]; other site
297246008126	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
297246008127	Sulfate transporter family; Region: Sulfate_transp; cl15842
297246008128	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
297246008129	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
297246008130	ligand binding site [chemical binding]; other site
297246008131	flexible hinge region; other site
297246008132	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
297246008133	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
297246008134	active site
297246008135	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
297246008136	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
297246008137	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
297246008138	GTP/Mg2+ binding site [chemical binding]; other site
297246008139	G4 box; other site
297246008140	G5 box; other site
297246008141	trmE is a tRNA modification GTPase; Region: trmE; cd04164
297246008142	G1 box; other site
297246008143	G1 box; other site
297246008144	GTP/Mg2+ binding site [chemical binding]; other site
297246008145	Switch I region; other site
297246008146	Switch I region; other site
297246008147	G2 box; other site
297246008148	G2 box; other site
297246008149	Switch II region; other site
297246008150	G3 box; other site
297246008151	G4 box; other site
297246008152	G5 box; other site
297246008153	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
297246008154	membrane protein insertase; Provisional; Region: PRK01318
297246008155	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
297246008156	Haemolytic domain; Region: Haemolytic; cl00506
297246008157	Ribonuclease P; Region: Ribonuclease_P; cl00457
297246008158	Ribosomal protein L34; Region: Ribosomal_L34; cl00370