-- dump date 20111121_012916 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762550000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 762550000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550000003 Walker A motif; other site 762550000004 ATP binding site [chemical binding]; other site 762550000005 Walker B motif; other site 762550000006 arginine finger; other site 762550000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762550000008 DnaA box-binding interface [nucleotide binding]; other site 762550000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 762550000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 762550000011 putative DNA binding surface [nucleotide binding]; other site 762550000012 dimer interface [polypeptide binding]; other site 762550000013 beta-clamp/clamp loader binding surface; other site 762550000014 beta-clamp/translesion DNA polymerase binding surface; other site 762550000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762550000016 recombination protein F; Reviewed; Region: recF; PRK00064 762550000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 762550000018 Walker A/P-loop; other site 762550000019 ATP binding site [chemical binding]; other site 762550000020 Q-loop/lid; other site 762550000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000022 ABC transporter signature motif; other site 762550000023 Walker B; other site 762550000024 D-loop; other site 762550000025 H-loop/switch region; other site 762550000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762550000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 762550000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 762550000029 anchoring element; other site 762550000030 dimer interface [polypeptide binding]; other site 762550000031 ATP binding site [chemical binding]; other site 762550000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762550000033 active site 762550000034 putative metal-binding site [ion binding]; other site 762550000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762550000036 DNA gyrase subunit A; Validated; Region: PRK05560 762550000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 762550000038 CAP-like domain; other site 762550000039 Active site [active] 762550000040 primary dimer interface [polypeptide binding]; other site 762550000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000047 PspC domain; Region: PspC; cl00864 762550000048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000049 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762550000050 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000051 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550000052 Walker A/P-loop; other site 762550000053 ATP binding site [chemical binding]; other site 762550000054 Q-loop/lid; other site 762550000055 ABC transporter signature motif; other site 762550000056 Walker B; other site 762550000057 D-loop; other site 762550000058 H-loop/switch region; other site 762550000059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762550000060 FtsX-like permease family; Region: FtsX; pfam02687 762550000061 C-terminal domain; Region: RGG_Cterm; TIGR01716 762550000062 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000063 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000064 Walker A/P-loop; other site 762550000065 ATP binding site [chemical binding]; other site 762550000066 Q-loop/lid; other site 762550000067 ABC transporter signature motif; other site 762550000068 Walker B; other site 762550000069 D-loop; other site 762550000070 H-loop/switch region; other site 762550000071 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650 762550000072 active site 762550000073 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 762550000074 active site 762550000075 tetramer interface [polypeptide binding]; other site 762550000076 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 762550000077 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 762550000078 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 762550000079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000081 DNA binding site [nucleotide binding] 762550000082 domain linker motif; other site 762550000083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550000084 dimerization interface [polypeptide binding]; other site 762550000085 ligand binding site [chemical binding]; other site 762550000086 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 762550000087 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 762550000088 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 762550000089 Walker A/P-loop; other site 762550000090 ATP binding site [chemical binding]; other site 762550000091 Q-loop/lid; other site 762550000092 ABC transporter signature motif; other site 762550000093 Walker B; other site 762550000094 D-loop; other site 762550000095 H-loop/switch region; other site 762550000096 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 762550000097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762550000098 TM-ABC transporter signature motif; other site 762550000099 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 762550000100 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 762550000101 ligand binding site [chemical binding]; other site 762550000102 dimerization interface [polypeptide binding]; other site 762550000103 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 762550000104 substrate binding site [chemical binding]; other site 762550000105 dimer interface [polypeptide binding]; other site 762550000106 ATP binding site [chemical binding]; other site 762550000107 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550000108 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000109 active site 762550000110 dimer interface [polypeptide binding]; other site 762550000111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550000112 Cupin domain; Region: Cupin_2; cl09118 762550000113 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762550000114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762550000115 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550000116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 762550000117 active site turn [active] 762550000118 phosphorylation site [posttranslational modification] 762550000119 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550000120 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762550000121 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550000122 substrate binding [chemical binding]; other site 762550000123 active site 762550000124 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762550000125 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 762550000126 HPr interaction site; other site 762550000127 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550000128 active site 762550000129 phosphorylation site [posttranslational modification] 762550000130 Predicted transcriptional regulator [Transcription]; Region: COG1395 762550000131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000132 non-specific DNA binding site [nucleotide binding]; other site 762550000133 salt bridge; other site 762550000134 sequence-specific DNA binding site [nucleotide binding]; other site 762550000135 Putative cyclase; Region: Cyclase; cl00814 762550000136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762550000137 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 762550000138 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 762550000139 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000141 dimer interface [polypeptide binding]; other site 762550000142 conserved gate region; other site 762550000143 putative PBP binding loops; other site 762550000144 ABC-ATPase subunit interface; other site 762550000145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550000146 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550000147 substrate binding pocket [chemical binding]; other site 762550000148 membrane-bound complex binding site; other site 762550000149 hinge residues; other site 762550000150 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550000151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000152 dimer interface [polypeptide binding]; other site 762550000153 conserved gate region; other site 762550000154 putative PBP binding loops; other site 762550000155 ABC-ATPase subunit interface; other site 762550000156 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000157 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762550000158 Walker A/P-loop; other site 762550000159 ATP binding site [chemical binding]; other site 762550000160 Q-loop/lid; other site 762550000161 ABC transporter signature motif; other site 762550000162 Walker B; other site 762550000163 D-loop; other site 762550000164 H-loop/switch region; other site 762550000165 aspartate aminotransferase; Provisional; Region: PRK08361 762550000166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550000167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000168 homodimer interface [polypeptide binding]; other site 762550000169 catalytic residue [active] 762550000170 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762550000171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000172 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000173 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762550000174 Walker A/P-loop; other site 762550000175 ATP binding site [chemical binding]; other site 762550000176 Q-loop/lid; other site 762550000177 ABC transporter signature motif; other site 762550000178 Walker B; other site 762550000179 D-loop; other site 762550000180 H-loop/switch region; other site 762550000181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000183 putative substrate translocation pore; other site 762550000184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762550000185 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 762550000186 putative active site [active] 762550000187 putative FMN binding site [chemical binding]; other site 762550000188 putative substrate binding site [chemical binding]; other site 762550000189 putative catalytic residue [active] 762550000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000192 putative substrate translocation pore; other site 762550000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000194 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 762550000195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000196 EamA-like transporter family; Region: EamA; cl01037 762550000197 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762550000198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762550000200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000201 non-specific DNA binding site [nucleotide binding]; other site 762550000202 salt bridge; other site 762550000203 sequence-specific DNA binding site [nucleotide binding]; other site 762550000204 potential frameshift: common BLAST hit: gi|116618234|ref|YP_818605.1| IS30 family transposase 762550000205 Integrase core domain; Region: rve; cl01316 762550000206 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762550000207 Citrate transporter; Region: CitMHS; pfam03600 762550000208 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 762550000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000210 NAD(P) binding site [chemical binding]; other site 762550000211 active site 762550000212 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550000213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000216 DNA binding site [nucleotide binding] 762550000217 domain linker motif; other site 762550000218 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 762550000219 putative dimerization interface [polypeptide binding]; other site 762550000220 putative ligand binding site [chemical binding]; other site 762550000221 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 762550000222 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 762550000223 DNA binding residues [nucleotide binding] 762550000224 putative dimer interface [polypeptide binding]; other site 762550000225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000226 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550000227 Walker A/P-loop; other site 762550000228 ATP binding site [chemical binding]; other site 762550000229 Q-loop/lid; other site 762550000230 ABC transporter signature motif; other site 762550000231 Walker B; other site 762550000232 D-loop; other site 762550000233 H-loop/switch region; other site 762550000234 FtsX-like permease family; Region: FtsX; pfam02687 762550000235 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 762550000236 FtsX-like permease family; Region: FtsX; pfam02687 762550000237 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550000238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000239 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550000240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550000241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550000242 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550000243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550000245 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550000246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000247 Walker A/P-loop; other site 762550000248 ATP binding site [chemical binding]; other site 762550000249 Q-loop/lid; other site 762550000250 ABC transporter signature motif; other site 762550000251 Walker B; other site 762550000252 D-loop; other site 762550000253 H-loop/switch region; other site 762550000254 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550000255 Domain of unknown function DUF87; Region: DUF87; pfam01935 762550000256 AAA-like domain; Region: AAA_10; pfam12846 762550000257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000259 DNA binding site [nucleotide binding] 762550000260 domain linker motif; other site 762550000261 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550000262 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 762550000263 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550000264 substrate binding [chemical binding]; other site 762550000265 active site 762550000266 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762550000267 galactoside permease; Reviewed; Region: lacY; PRK09528 762550000268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000269 putative substrate translocation pore; other site 762550000270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550000271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000272 salt bridge; other site 762550000273 non-specific DNA binding site [nucleotide binding]; other site 762550000274 sequence-specific DNA binding site [nucleotide binding]; other site 762550000275 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 762550000276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000277 Walker A/P-loop; other site 762550000278 ATP binding site [chemical binding]; other site 762550000279 ABC transporter signature motif; other site 762550000280 Walker B; other site 762550000281 D-loop; other site 762550000282 H-loop/switch region; other site 762550000283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550000284 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550000285 putative transposase OrfB; Reviewed; Region: PHA02517 762550000286 Integrase core domain; Region: rve; cl01316 762550000287 Protein of unknown function (DUF975); Region: DUF975; cl10504 762550000288 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 762550000289 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762550000290 active site 762550000291 HIGH motif; other site 762550000292 dimer interface [polypeptide binding]; other site 762550000293 KMSKS motif; other site 762550000294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762550000295 D-lactate dehydrogenase; Validated; Region: PRK08605 762550000296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762550000298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000299 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 762550000300 putative transporter; Provisional; Region: PRK03699 762550000301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000302 putative substrate translocation pore; other site 762550000303 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762550000304 active site 762550000305 metal binding site [ion binding]; metal-binding site 762550000306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000307 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 762550000308 potential frameshift: common BLAST hit: gi|170016351|ref|YP_001727271.1| putative transfer protein 762550000309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550000310 active site 762550000311 motif I; other site 762550000312 motif II; other site 762550000313 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550000314 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 762550000315 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762550000316 minor groove reading motif; other site 762550000317 helix-hairpin-helix signature motif; other site 762550000318 substrate binding pocket [chemical binding]; other site 762550000319 active site 762550000320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550000321 S-adenosylmethionine binding site [chemical binding]; other site 762550000322 potential frameshift: common BLAST hit: gi|170017565|ref|YP_001728484.1| transposase 762550000323 putative transposase OrfB; Reviewed; Region: PHA02517 762550000324 YcaO-like family; Region: YcaO; cl09146 762550000325 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762550000326 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550000327 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550000328 potential frameshift: common BLAST hit: gi|81428617|ref|YP_395617.1| putative zinc-containing alcohol dehydrogenase (oxidoreductase) 762550000329 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762550000330 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762550000331 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762550000332 substrate binding site [chemical binding]; other site 762550000333 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762550000334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000335 Walker A/P-loop; other site 762550000336 ATP binding site [chemical binding]; other site 762550000337 Q-loop/lid; other site 762550000338 ABC transporter signature motif; other site 762550000339 Walker B; other site 762550000340 D-loop; other site 762550000341 H-loop/switch region; other site 762550000342 TOBE domain; Region: TOBE_2; cl01440 762550000343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000344 dimer interface [polypeptide binding]; other site 762550000345 conserved gate region; other site 762550000346 putative PBP binding loops; other site 762550000347 ABC-ATPase subunit interface; other site 762550000348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000349 dimer interface [polypeptide binding]; other site 762550000350 conserved gate region; other site 762550000351 putative PBP binding loops; other site 762550000352 ABC-ATPase subunit interface; other site 762550000353 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762550000354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550000355 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550000356 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762550000357 active site 762550000358 catalytic site [active] 762550000359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550000360 catalytic core [active] 762550000361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000362 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000363 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000364 putative NAD(P) binding site [chemical binding]; other site 762550000365 NlpC/P60 family; Region: NLPC_P60; cl11438 762550000366 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 762550000367 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 762550000368 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762550000369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 762550000370 active site 762550000371 phosphorylation site [posttranslational modification] 762550000372 intermolecular recognition site; other site 762550000373 dimerization interface [polypeptide binding]; other site 762550000374 LytTr DNA-binding domain; Region: LytTR; cl04498 762550000375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 762550000376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550000377 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550000378 active site 762550000379 motif I; other site 762550000380 motif II; other site 762550000381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550000382 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762550000383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762550000384 transcriptional antiterminator BglG; Provisional; Region: PRK09772 762550000385 CAT RNA binding domain; Region: CAT_RBD; pfam03123 762550000386 PRD domain; Region: PRD; pfam00874 762550000387 PRD domain; Region: PRD; pfam00874 762550000388 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 762550000389 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 762550000390 active site turn [active] 762550000391 phosphorylation site [posttranslational modification] 762550000392 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550000393 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 762550000394 HPr interaction site; other site 762550000395 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550000396 active site 762550000397 phosphorylation site [posttranslational modification] 762550000398 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762550000399 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 762550000400 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 762550000401 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 762550000402 dimer interface [polypeptide binding]; other site 762550000403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000404 catalytic residue [active] 762550000405 cystathionine beta-lyase; Provisional; Region: PRK07671 762550000406 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762550000407 homodimer interface [polypeptide binding]; other site 762550000408 substrate-cofactor binding pocket; other site 762550000409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000410 catalytic residue [active] 762550000411 serine O-acetyltransferase; Region: cysE; TIGR01172 762550000412 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 762550000413 trimer interface [polypeptide binding]; other site 762550000414 active site 762550000415 substrate binding site [chemical binding]; other site 762550000416 CoA binding site [chemical binding]; other site 762550000417 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 762550000418 Predicted transcriptional regulators [Transcription]; Region: COG1725 762550000419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550000420 DNA-binding site [nucleotide binding]; DNA binding site 762550000421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762550000422 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762550000423 Walker A/P-loop; other site 762550000424 ATP binding site [chemical binding]; other site 762550000425 Q-loop/lid; other site 762550000426 ABC transporter signature motif; other site 762550000427 Walker B; other site 762550000428 D-loop; other site 762550000429 H-loop/switch region; other site 762550000430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000431 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 762550000432 Walker A/P-loop; other site 762550000433 ATP binding site [chemical binding]; other site 762550000434 Q-loop/lid; other site 762550000435 ABC transporter signature motif; other site 762550000436 Walker B; other site 762550000437 D-loop; other site 762550000438 H-loop/switch region; other site 762550000439 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762550000440 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 762550000441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762550000442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550000443 active site 762550000444 catalytic tetrad [active] 762550000445 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 762550000446 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762550000447 metal binding site [ion binding]; metal-binding site 762550000448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000450 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550000451 Walker A/P-loop; other site 762550000452 ATP binding site [chemical binding]; other site 762550000453 Q-loop/lid; other site 762550000454 ABC transporter signature motif; other site 762550000455 Walker B; other site 762550000456 D-loop; other site 762550000457 H-loop/switch region; other site 762550000458 potential frameshift: common BLAST hit: gi|296110890|ref|YP_003621271.1| ABC transporter permease and substrate binding protein 762550000459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550000460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550000461 active site 762550000462 phosphorylation site [posttranslational modification] 762550000463 intermolecular recognition site; other site 762550000464 dimerization interface [polypeptide binding]; other site 762550000465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550000466 DNA binding site [nucleotide binding] 762550000467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550000468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550000469 ATP binding site [chemical binding]; other site 762550000470 Mg2+ binding site [ion binding]; other site 762550000471 G-X-G motif; other site 762550000472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000473 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 762550000474 Walker A/P-loop; other site 762550000475 ATP binding site [chemical binding]; other site 762550000476 Q-loop/lid; other site 762550000477 ABC transporter signature motif; other site 762550000478 Walker B; other site 762550000479 D-loop; other site 762550000480 H-loop/switch region; other site 762550000481 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 762550000482 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 762550000483 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762550000484 putative active site [active] 762550000485 catalytic site [active] 762550000486 putative metal binding site [ion binding]; other site 762550000487 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762550000488 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762550000489 Walker A/P-loop; other site 762550000490 ATP binding site [chemical binding]; other site 762550000491 Q-loop/lid; other site 762550000492 ABC transporter signature motif; other site 762550000493 Walker B; other site 762550000494 D-loop; other site 762550000495 H-loop/switch region; other site 762550000496 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000497 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762550000498 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762550000499 Walker A/P-loop; other site 762550000500 ATP binding site [chemical binding]; other site 762550000501 Q-loop/lid; other site 762550000502 ABC transporter signature motif; other site 762550000503 Walker B; other site 762550000504 D-loop; other site 762550000505 H-loop/switch region; other site 762550000506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000507 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762550000508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000509 dimer interface [polypeptide binding]; other site 762550000510 conserved gate region; other site 762550000511 putative PBP binding loops; other site 762550000512 ABC-ATPase subunit interface; other site 762550000513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000514 dimer interface [polypeptide binding]; other site 762550000515 conserved gate region; other site 762550000516 putative PBP binding loops; other site 762550000517 ABC-ATPase subunit interface; other site 762550000518 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762550000519 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762550000520 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 762550000521 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 762550000522 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 762550000523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000525 putative substrate translocation pore; other site 762550000526 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 762550000527 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550000528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550000529 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 762550000530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550000531 ATP binding site [chemical binding]; other site 762550000532 putative Mg++ binding site [ion binding]; other site 762550000533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550000534 nucleotide binding region [chemical binding]; other site 762550000535 ATP-binding site [chemical binding]; other site 762550000536 RQC domain; Region: RQC; pfam09382 762550000537 HRDC domain; Region: HRDC; cl02578 762550000538 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 762550000539 putative transporter; Provisional; Region: PRK11462 762550000540 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 762550000541 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 762550000542 inhibitor binding site; inhibition site 762550000543 active site 762550000544 WIF domain; Region: WIF; cl02623 762550000545 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 762550000546 catalytic residues [active] 762550000547 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762550000548 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550000549 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 762550000550 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550000551 D-xylulose kinase; Region: XylB; TIGR01312 762550000552 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 762550000553 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762550000554 Active site [active] 762550000555 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550000556 transmembrane helices; other site 762550000557 Domain of unknown function (DU1801); Region: DUF1801; cl01838 762550000558 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762550000559 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762550000560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000561 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550000562 putative peptidoglycan binding site; other site 762550000563 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550000564 putative peptidoglycan binding site; other site 762550000565 NlpC/P60 family; Region: NLPC_P60; cl11438 762550000566 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550000567 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 762550000568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762550000569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550000571 dimerization interface [polypeptide binding]; other site 762550000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000573 benzoate transport; Region: 2A0115; TIGR00895 762550000574 putative substrate translocation pore; other site 762550000575 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762550000576 nudix motif; other site 762550000577 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762550000578 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550000579 Protein of unknown function (DUF805); Region: DUF805; cl01224 762550000580 acetoin reductase; Validated; Region: PRK08643 762550000581 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 762550000582 NAD binding site [chemical binding]; other site 762550000583 homotetramer interface [polypeptide binding]; other site 762550000584 homodimer interface [polypeptide binding]; other site 762550000585 active site 762550000586 substrate binding site [chemical binding]; other site 762550000587 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 762550000588 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 762550000589 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762550000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000591 NAD(P) binding pocket [chemical binding]; other site 762550000592 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 762550000593 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550000594 active site 762550000595 nucleotide binding site [chemical binding]; other site 762550000596 HIGH motif; other site 762550000597 KMSKS motif; other site 762550000598 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 762550000599 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762550000600 citrate lyase, alpha subunit; Region: citF; TIGR01584 762550000601 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 762550000602 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 762550000603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762550000604 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 762550000605 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 762550000606 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 762550000607 putative catalytic cysteine [active] 762550000608 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 762550000609 putative active site [active] 762550000610 metal binding site [ion binding]; metal-binding site 762550000611 Predicted membrane protein [Function unknown]; Region: COG1511 762550000612 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550000613 Predicted transcriptional regulator [Transcription]; Region: COG1959 762550000614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000617 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550000618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550000619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550000620 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550000621 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000622 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000623 putative NAD(P) binding site [chemical binding]; other site 762550000624 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 762550000625 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550000626 MAEBL; Provisional; Region: PTZ00121 762550000627 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762550000628 active site 762550000629 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-...; Region: ClC_like; cd01033 762550000630 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 762550000631 putative ion selectivity filter; other site 762550000632 putative pore gating glutamate residue; other site 762550000633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000634 non-specific DNA binding site [nucleotide binding]; other site 762550000635 salt bridge; other site 762550000636 sequence-specific DNA binding site [nucleotide binding]; other site 762550000637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762550000638 active site 762550000639 metal binding site [ion binding]; metal-binding site 762550000640 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762550000641 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550000642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000643 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550000644 ABC transporter; Region: ABC_tran_2; pfam12848 762550000645 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550000646 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 762550000647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000648 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762550000649 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762550000650 BioY family; Region: BioY; cl00560 762550000651 hypothetical protein; Provisional; Region: PRK13679 762550000652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000653 alanine racemase; Reviewed; Region: alr; PRK00053 762550000654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762550000655 active site 762550000656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550000657 dimer interface [polypeptide binding]; other site 762550000658 substrate binding site [chemical binding]; other site 762550000659 catalytic residues [active] 762550000660 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 762550000661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000662 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 762550000663 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762550000664 putative active site [active] 762550000665 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550000666 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 762550000667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000668 Walker A/P-loop; other site 762550000669 ATP binding site [chemical binding]; other site 762550000670 Q-loop/lid; other site 762550000671 ABC transporter signature motif; other site 762550000672 Walker B; other site 762550000673 D-loop; other site 762550000674 H-loop/switch region; other site 762550000675 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 762550000676 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550000677 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 762550000678 Walker A/P-loop; other site 762550000679 ATP binding site [chemical binding]; other site 762550000680 Q-loop/lid; other site 762550000681 ABC transporter signature motif; other site 762550000682 Walker B; other site 762550000683 D-loop; other site 762550000684 H-loop/switch region; other site 762550000685 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000686 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762550000687 Walker A/P-loop; other site 762550000688 ATP binding site [chemical binding]; other site 762550000689 Q-loop/lid; other site 762550000690 ABC transporter signature motif; other site 762550000691 Walker B; other site 762550000692 D-loop; other site 762550000693 H-loop/switch region; other site 762550000694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550000695 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550000696 substrate binding pocket [chemical binding]; other site 762550000697 membrane-bound complex binding site; other site 762550000698 hinge residues; other site 762550000699 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550000700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000701 dimer interface [polypeptide binding]; other site 762550000702 conserved gate region; other site 762550000703 putative PBP binding loops; other site 762550000704 ABC-ATPase subunit interface; other site 762550000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000706 dimer interface [polypeptide binding]; other site 762550000707 putative PBP binding loops; other site 762550000708 ABC-ATPase subunit interface; other site 762550000709 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550000710 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550000711 peptide binding site [polypeptide binding]; other site 762550000712 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550000713 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550000714 peptide binding site [polypeptide binding]; other site 762550000715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762550000716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000717 dimer interface [polypeptide binding]; other site 762550000718 conserved gate region; other site 762550000719 putative PBP binding loops; other site 762550000720 ABC-ATPase subunit interface; other site 762550000721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762550000722 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762550000723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550000724 dimer interface [polypeptide binding]; other site 762550000725 conserved gate region; other site 762550000726 putative PBP binding loops; other site 762550000727 ABC-ATPase subunit interface; other site 762550000728 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762550000729 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762550000730 Walker A/P-loop; other site 762550000731 ATP binding site [chemical binding]; other site 762550000732 Q-loop/lid; other site 762550000733 ABC transporter signature motif; other site 762550000734 Walker B; other site 762550000735 D-loop; other site 762550000736 H-loop/switch region; other site 762550000737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000738 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762550000739 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 762550000740 Walker A/P-loop; other site 762550000741 ATP binding site [chemical binding]; other site 762550000742 Q-loop/lid; other site 762550000743 ABC transporter signature motif; other site 762550000744 Walker B; other site 762550000745 D-loop; other site 762550000746 H-loop/switch region; other site 762550000747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000748 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 762550000749 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 762550000750 active site 762550000751 Zn binding site [ion binding]; other site 762550000752 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762550000753 Protein of unknown function (DUF419); Region: DUF419; cl09948 762550000754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550000755 FeS assembly ATPase SufC; Region: sufC; TIGR01978 762550000756 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 762550000757 Walker A/P-loop; other site 762550000758 ATP binding site [chemical binding]; other site 762550000759 Q-loop/lid; other site 762550000760 ABC transporter signature motif; other site 762550000761 Walker B; other site 762550000762 D-loop; other site 762550000763 H-loop/switch region; other site 762550000764 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 762550000765 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 762550000766 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 762550000767 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762550000768 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 762550000769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550000770 catalytic residue [active] 762550000771 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762550000772 trimerization site [polypeptide binding]; other site 762550000773 active site 762550000774 FeS assembly protein SufB; Region: sufB; TIGR01980 762550000775 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 762550000776 Domain of unknown function DUF59; Region: DUF59; cl00941 762550000777 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 762550000778 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 762550000779 active site 762550000780 catalytic residues [active] 762550000781 metal binding site [ion binding]; metal-binding site 762550000782 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 762550000783 isocitrate dehydrogenase; Validated; Region: PRK06451 762550000784 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762550000785 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762550000786 substrate binding site [chemical binding]; other site 762550000787 ligand binding site [chemical binding]; other site 762550000788 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 762550000789 substrate binding site [chemical binding]; other site 762550000790 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 762550000791 High-affinity nickel-transport protein; Region: NicO; cl00964 762550000792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550000793 DNA-binding site [nucleotide binding]; DNA binding site 762550000794 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 762550000795 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 762550000796 putative dimerization interface [polypeptide binding]; other site 762550000797 putative ligand binding site [chemical binding]; other site 762550000798 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 762550000799 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 762550000800 hypothetical protein; Provisional; Region: PRK08185 762550000801 intersubunit interface [polypeptide binding]; other site 762550000802 active site 762550000803 zinc binding site [ion binding]; other site 762550000804 Na+ binding site [ion binding]; other site 762550000805 L-arabinose isomerase; Provisional; Region: PRK02929 762550000806 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 762550000807 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762550000808 trimer interface [polypeptide binding]; other site 762550000809 substrate binding site [chemical binding]; other site 762550000810 Mn binding site [ion binding]; other site 762550000811 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 762550000812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000813 putative substrate translocation pore; other site 762550000814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000815 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762550000816 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550000817 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 762550000818 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 762550000819 intersubunit interface [polypeptide binding]; other site 762550000820 active site 762550000821 Zn2+ binding site [ion binding]; other site 762550000822 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 762550000823 Aspartase; Region: Aspartase; cd01357 762550000824 active sites [active] 762550000825 tetramer interface [polypeptide binding]; other site 762550000826 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550000827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000828 active site 762550000829 dimer interface [polypeptide binding]; other site 762550000830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550000831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 762550000832 ABC-ATPase subunit interface; other site 762550000833 dimer interface [polypeptide binding]; other site 762550000834 putative PBP binding regions; other site 762550000835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550000836 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 762550000837 Walker A/P-loop; other site 762550000838 ATP binding site [chemical binding]; other site 762550000839 Q-loop/lid; other site 762550000840 ABC transporter signature motif; other site 762550000841 Walker B; other site 762550000842 D-loop; other site 762550000843 H-loop/switch region; other site 762550000844 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 762550000845 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762550000846 metal binding site [ion binding]; metal-binding site 762550000847 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762550000848 trimer interface [polypeptide binding]; other site 762550000849 active site 762550000850 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762550000851 DNA repair protein RadA; Provisional; Region: PRK11823 762550000852 Walker A motif/ATP binding site; other site 762550000853 ATP binding site [chemical binding]; other site 762550000854 Walker B motif; other site 762550000855 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762550000856 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550000857 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550000858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550000859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550000860 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762550000861 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762550000862 active site 762550000863 HIGH motif; other site 762550000864 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762550000865 active site 762550000866 KMSKS motif; other site 762550000867 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000868 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000869 putative NAD(P) binding site [chemical binding]; other site 762550000870 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 762550000871 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762550000872 NAD binding site [chemical binding]; other site 762550000873 substrate binding site [chemical binding]; other site 762550000874 catalytic Zn binding site [ion binding]; other site 762550000875 tetramer interface [polypeptide binding]; other site 762550000876 structural Zn binding site [ion binding]; other site 762550000877 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 762550000878 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 762550000879 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550000880 Walker A/P-loop; other site 762550000881 ATP binding site [chemical binding]; other site 762550000882 Q-loop/lid; other site 762550000883 ABC transporter signature motif; other site 762550000884 Walker B; other site 762550000885 D-loop; other site 762550000886 H-loop/switch region; other site 762550000887 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 762550000888 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550000889 Walker A/P-loop; other site 762550000890 ATP binding site [chemical binding]; other site 762550000891 Q-loop/lid; other site 762550000892 ABC transporter signature motif; other site 762550000893 Walker B; other site 762550000894 D-loop; other site 762550000895 H-loop/switch region; other site 762550000896 Cobalt transport protein; Region: CbiQ; cl00463 762550000897 dipeptidase PepV; Reviewed; Region: PRK07318 762550000898 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762550000899 active site 762550000900 metal binding site [ion binding]; metal-binding site 762550000901 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 762550000902 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762550000903 dimer interface [polypeptide binding]; other site 762550000904 ssDNA binding site [nucleotide binding]; other site 762550000905 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000906 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 762550000907 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 762550000908 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 762550000909 DHH family; Region: DHH; pfam01368 762550000910 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762550000911 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762550000912 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762550000913 replicative DNA helicase; Region: DnaB; TIGR00665 762550000914 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762550000915 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762550000916 Walker A motif; other site 762550000917 ATP binding site [chemical binding]; other site 762550000918 Walker B motif; other site 762550000919 DNA binding loops [nucleotide binding] 762550000920 SprT homologues; Region: SprT; cl01182 762550000921 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 762550000922 putative deacylase active site [active] 762550000923 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550000924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550000925 DNA-binding site [nucleotide binding]; DNA binding site 762550000926 UTRA domain; Region: UTRA; cl06649 762550000927 putative phosphoketolase; Provisional; Region: PRK05261 762550000928 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762550000929 TPP-binding site [chemical binding]; other site 762550000930 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 762550000931 XFP C-terminal domain; Region: XFP_C; pfam09363 762550000932 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762550000933 nudix motif; other site 762550000934 sugar phosphate phosphatase; Provisional; Region: PRK10513 762550000935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550000936 active site 762550000937 motif I; other site 762550000938 motif II; other site 762550000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550000940 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 762550000941 dimer interface [polypeptide binding]; other site 762550000942 catalytic triad [active] 762550000943 peroxidatic and resolving cysteines [active] 762550000944 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 762550000945 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550000946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550000947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550000948 active site 762550000949 phosphorylation site [posttranslational modification] 762550000950 intermolecular recognition site; other site 762550000951 dimerization interface [polypeptide binding]; other site 762550000952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550000953 DNA binding site [nucleotide binding] 762550000954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 762550000955 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762550000956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762550000957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762550000958 dimer interface [polypeptide binding]; other site 762550000959 phosphorylation site [posttranslational modification] 762550000960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550000961 ATP binding site [chemical binding]; other site 762550000962 Mg2+ binding site [ion binding]; other site 762550000963 G-X-G motif; other site 762550000964 YycH protein; Region: YycH; pfam07435 762550000965 YycH protein; Region: YycI; cl02015 762550000966 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 762550000967 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 762550000968 protein binding site [polypeptide binding]; other site 762550000969 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 762550000970 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 762550000971 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550000972 dimer interface [polypeptide binding]; other site 762550000973 substrate binding site [chemical binding]; other site 762550000974 ATP binding site [chemical binding]; other site 762550000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000977 putative substrate translocation pore; other site 762550000978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000979 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762550000980 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762550000981 minor groove reading motif; other site 762550000982 helix-hairpin-helix signature motif; other site 762550000983 substrate binding pocket [chemical binding]; other site 762550000984 active site 762550000985 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 762550000986 DNA binding and oxoG recognition site [nucleotide binding] 762550000987 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762550000988 Domain of unknown function DUF20; Region: UPF0118; cl00465 762550000989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550000990 hypothetical protein; Validated; Region: PRK07668 762550000991 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550000992 TRAM domain; Region: TRAM; cl01282 762550000993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550000994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550000995 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 762550000996 Walker A motif; other site 762550000997 ATP binding site [chemical binding]; other site 762550000998 Walker B motif; other site 762550000999 arginine finger; other site 762550001000 UvrB/uvrC motif; Region: UVR; pfam02151 762550001001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001002 Walker A motif; other site 762550001003 ATP binding site [chemical binding]; other site 762550001004 Walker B motif; other site 762550001005 arginine finger; other site 762550001006 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550001007 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 762550001008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001009 DNA-binding site [nucleotide binding]; DNA binding site 762550001010 UTRA domain; Region: UTRA; cl06649 762550001011 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 762550001012 HPr interaction site; other site 762550001013 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550001014 active site 762550001015 phosphorylation site [posttranslational modification] 762550001016 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550001017 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 762550001018 active site turn [active] 762550001019 phosphorylation site [posttranslational modification] 762550001020 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550001021 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 762550001022 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 762550001023 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 762550001024 beta-phosphoglucomutase; Region: bPGM; TIGR01990 762550001025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550001026 Membrane transport protein; Region: Mem_trans; cl09117 762550001027 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762550001028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001029 sensory histidine kinase DcuS; Provisional; Region: PRK11086 762550001030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001031 ATP binding site [chemical binding]; other site 762550001032 Mg2+ binding site [ion binding]; other site 762550001033 G-X-G motif; other site 762550001034 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 762550001035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550001036 active site 762550001037 phosphorylation site [posttranslational modification] 762550001038 intermolecular recognition site; other site 762550001039 dimerization interface [polypeptide binding]; other site 762550001040 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 762550001041 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762550001042 nudix motif; other site 762550001043 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 762550001044 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762550001045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001046 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762550001047 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 762550001048 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762550001049 active site 762550001050 HIGH motif; other site 762550001051 dimer interface [polypeptide binding]; other site 762550001052 KMSKS motif; other site 762550001053 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550001054 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762550001055 active site 762550001056 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550001057 Amino acid permease; Region: AA_permease; pfam00324 762550001058 rod shape-determining protein MreB; Provisional; Region: PRK13930 762550001059 Cell division protein FtsA; Region: FtsA; cl11496 762550001060 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 762550001061 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 762550001062 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 762550001063 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 762550001064 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762550001065 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550001066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001067 non-specific DNA binding site [nucleotide binding]; other site 762550001068 salt bridge; other site 762550001069 sequence-specific DNA binding site [nucleotide binding]; other site 762550001070 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550001071 Ligand Binding Site [chemical binding]; other site 762550001072 recombination factor protein RarA; Reviewed; Region: PRK13342 762550001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001074 Walker A motif; other site 762550001075 ATP binding site [chemical binding]; other site 762550001076 Walker B motif; other site 762550001077 arginine finger; other site 762550001078 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 762550001079 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 762550001080 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762550001081 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762550001082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550001083 RNA binding surface [nucleotide binding]; other site 762550001084 septation ring formation regulator EzrA; Provisional; Region: PRK04778 762550001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550001086 Predicted membrane protein [Function unknown]; Region: COG1511 762550001087 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550001088 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550001089 Amastin surface glycoprotein; Region: Amastin; cl06401 762550001090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550001091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550001092 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 762550001093 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 762550001094 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762550001095 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762550001096 putative homodimer interface [polypeptide binding]; other site 762550001097 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762550001098 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762550001099 23S rRNA interface [nucleotide binding]; other site 762550001100 L7/L12 interface [polypeptide binding]; other site 762550001101 putative thiostrepton binding site; other site 762550001102 L25 interface [polypeptide binding]; other site 762550001103 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 762550001104 mRNA/rRNA interface [nucleotide binding]; other site 762550001105 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 762550001106 23S rRNA interface [nucleotide binding]; other site 762550001107 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762550001108 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762550001109 peripheral dimer interface [polypeptide binding]; other site 762550001110 core dimer interface [polypeptide binding]; other site 762550001111 L10 interface [polypeptide binding]; other site 762550001112 L11 interface [polypeptide binding]; other site 762550001113 putative EF-Tu interaction site [polypeptide binding]; other site 762550001114 putative EF-G interaction site [polypeptide binding]; other site 762550001115 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 762550001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550001117 S-adenosylmethionine binding site [chemical binding]; other site 762550001118 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762550001119 nucleoside/Zn binding site; other site 762550001120 dimer interface [polypeptide binding]; other site 762550001121 catalytic motif [active] 762550001122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550001123 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 762550001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001125 Walker A motif; other site 762550001126 ATP binding site [chemical binding]; other site 762550001127 Walker B motif; other site 762550001128 recombination protein RecR; Reviewed; Region: recR; PRK00076 762550001129 RecR protein; Region: RecR; pfam02132 762550001130 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762550001131 putative active site [active] 762550001132 putative metal-binding site [ion binding]; other site 762550001133 tetramer interface [polypeptide binding]; other site 762550001134 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 762550001135 thymidylate kinase; Validated; Region: tmk; PRK00698 762550001136 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 762550001137 TMP-binding site; other site 762550001138 ATP-binding site [chemical binding]; other site 762550001139 Nitrogen regulatory protein P-II; Region: P-II; cl00412 762550001140 DNA polymerase III subunit delta'; Validated; Region: PRK08058 762550001141 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550001142 Predicted methyltransferases [General function prediction only]; Region: COG0313 762550001143 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 762550001144 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 762550001145 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 762550001146 active site 762550001147 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762550001148 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 762550001149 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762550001150 NAD binding site [chemical binding]; other site 762550001151 homodimer interface [polypeptide binding]; other site 762550001152 active site 762550001153 substrate binding site [chemical binding]; other site 762550001154 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 762550001155 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762550001156 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 762550001157 Substrate-binding site [chemical binding]; other site 762550001158 Substrate specificity [chemical binding]; other site 762550001159 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 762550001160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001161 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 762550001162 active site 762550001163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762550001164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 762550001166 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762550001167 ATP binding site [chemical binding]; other site 762550001168 putative Mg++ binding site [ion binding]; other site 762550001169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001170 nucleotide binding region [chemical binding]; other site 762550001171 ATP-binding site [chemical binding]; other site 762550001172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550001174 active site 762550001175 phosphorylation site [posttranslational modification] 762550001176 intermolecular recognition site; other site 762550001177 dimerization interface [polypeptide binding]; other site 762550001178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550001179 DNA binding site [nucleotide binding] 762550001180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762550001181 dimer interface [polypeptide binding]; other site 762550001182 phosphorylation site [posttranslational modification] 762550001183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001184 ATP binding site [chemical binding]; other site 762550001185 Mg2+ binding site [ion binding]; other site 762550001186 G-X-G motif; other site 762550001187 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 762550001188 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550001189 catalytic residues [active] 762550001190 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762550001191 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 762550001192 substrate binding site [chemical binding]; other site 762550001193 THF binding site; other site 762550001194 zinc-binding site [ion binding]; other site 762550001195 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 762550001196 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550001197 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550001198 peptide binding site [polypeptide binding]; other site 762550001199 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 762550001200 Peptidase C26; Region: Peptidase_C26; pfam07722 762550001201 catalytic triad [active] 762550001202 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762550001203 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 762550001204 catalytic triad [active] 762550001205 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550001206 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 762550001207 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550001208 NlpC/P60 family; Region: NLPC_P60; cl11438 762550001209 Thymidine kinase; Region: TK; cl00631 762550001210 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762550001211 RF-1 domain; Region: RF-1; cl02875 762550001212 RF-1 domain; Region: RF-1; cl02875 762550001213 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762550001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550001215 S-adenosylmethionine binding site [chemical binding]; other site 762550001216 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 762550001217 SUA5 domain; Region: SUA5; pfam03481 762550001218 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762550001219 dimerization domain swap beta strand [polypeptide binding]; other site 762550001220 regulatory protein interface [polypeptide binding]; other site 762550001221 active site 762550001222 regulatory phosphorylation site [posttranslational modification]; other site 762550001223 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762550001224 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762550001225 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 762550001226 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762550001227 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 762550001228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550001229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550001230 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 762550001231 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762550001232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550001233 Coenzyme A binding pocket [chemical binding]; other site 762550001234 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762550001235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550001236 UGMP family protein; Validated; Region: PRK09604 762550001237 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 762550001238 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 762550001239 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 762550001240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001241 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762550001242 FemAB family; Region: FemAB; cl11444 762550001243 FemAB family; Region: FemAB; cl11444 762550001244 GtrA-like protein; Region: GtrA; cl00971 762550001245 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550001246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550001247 active site 762550001248 motif I; other site 762550001249 motif II; other site 762550001250 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 762550001251 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 762550001252 dimer interface [polypeptide binding]; other site 762550001253 FMN binding site [chemical binding]; other site 762550001254 NADPH bind site [chemical binding]; other site 762550001255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001256 non-specific DNA binding site [nucleotide binding]; other site 762550001257 salt bridge; other site 762550001258 sequence-specific DNA binding site [nucleotide binding]; other site 762550001259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001260 non-specific DNA binding site [nucleotide binding]; other site 762550001261 salt bridge; other site 762550001262 sequence-specific DNA binding site [nucleotide binding]; other site 762550001263 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550001264 MucBP domain; Region: MucBP; pfam06458 762550001265 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 762550001266 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 762550001267 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 762550001268 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 762550001269 active pocket/dimerization site; other site 762550001270 active site 762550001271 phosphorylation site [posttranslational modification] 762550001272 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 762550001273 active site 762550001274 phosphorylation site [posttranslational modification] 762550001275 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 762550001276 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 762550001277 Domain of unknown function (DUF956); Region: DUF956; cl01917 762550001278 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550001279 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550001280 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 762550001281 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 762550001282 oligomerisation interface [polypeptide binding]; other site 762550001283 mobile loop; other site 762550001284 roof hairpin; other site 762550001285 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762550001286 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762550001287 ring oligomerisation interface [polypeptide binding]; other site 762550001288 ATP/Mg binding site [chemical binding]; other site 762550001289 stacking interactions; other site 762550001290 hinge regions; other site 762550001291 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550001292 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 762550001293 trimer interface [polypeptide binding]; other site 762550001294 active site 762550001295 G bulge; other site 762550001296 UbiA prenyltransferase family; Region: UbiA; cl00337 762550001297 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 762550001298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 762550001299 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762550001300 putative active site [active] 762550001301 catalytic residue [active] 762550001302 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762550001303 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 762550001304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550001305 ATP binding site [chemical binding]; other site 762550001306 putative Mg++ binding site [ion binding]; other site 762550001307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001308 nucleotide binding region [chemical binding]; other site 762550001309 ATP-binding site [chemical binding]; other site 762550001310 TRCF domain; Region: TRCF; pfam03461 762550001311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762550001312 Septum formation initiator; Region: DivIC; cl11433 762550001313 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762550001314 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762550001315 Ligand Binding Site [chemical binding]; other site 762550001316 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550001317 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 762550001318 FtsH Extracellular; Region: FtsH_ext; pfam06480 762550001319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001320 Walker A motif; other site 762550001321 ATP binding site [chemical binding]; other site 762550001322 Walker B motif; other site 762550001323 arginine finger; other site 762550001324 Peptidase family M41; Region: Peptidase_M41; pfam01434 762550001325 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 762550001326 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 762550001327 dimerization interface [polypeptide binding]; other site 762550001328 domain crossover interface; other site 762550001329 redox-dependent activation switch; other site 762550001330 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762550001331 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 762550001332 dimer interface [polypeptide binding]; other site 762550001333 putative anticodon binding site; other site 762550001334 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762550001335 motif 1; other site 762550001336 active site 762550001337 motif 2; other site 762550001338 motif 3; other site 762550001339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550001340 putative substrate translocation pore; other site 762550001341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550001342 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762550001343 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550001344 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 762550001345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550001346 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550001347 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550001348 Walker A/P-loop; other site 762550001349 ATP binding site [chemical binding]; other site 762550001350 Q-loop/lid; other site 762550001351 ABC transporter signature motif; other site 762550001352 Walker B; other site 762550001353 D-loop; other site 762550001354 H-loop/switch region; other site 762550001355 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550001356 active site 762550001357 HIGH motif; other site 762550001358 nucleotide binding site [chemical binding]; other site 762550001359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001360 sequence-specific DNA binding site [nucleotide binding]; other site 762550001361 salt bridge; other site 762550001362 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 762550001363 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762550001364 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762550001365 Sulfate transporter family; Region: Sulfate_transp; cl00967 762550001366 Permease family; Region: Xan_ur_permease; pfam00860 762550001367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550001368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550001369 ABC transporter signature motif; other site 762550001370 Walker B; other site 762550001371 D-loop; other site 762550001372 H-loop/switch region; other site 762550001373 LytTr DNA-binding domain; Region: LytTR; cl04498 762550001374 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 762550001375 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_3; cd02653 762550001376 active site 762550001377 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550001378 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762550001379 active site 762550001380 putative interdomain interaction site [polypeptide binding]; other site 762550001381 putative metal-binding site [ion binding]; other site 762550001382 putative nucleotide binding site [chemical binding]; other site 762550001383 DNA topoisomerase; Region: Topoisom_bac; pfam01131 762550001384 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 762550001385 domain I; other site 762550001386 DNA binding groove [nucleotide binding] 762550001387 phosphate binding site [ion binding]; other site 762550001388 domain II; other site 762550001389 domain III; other site 762550001390 nucleotide binding site [chemical binding]; other site 762550001391 catalytic site [active] 762550001392 domain IV; other site 762550001393 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550001394 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762550001395 substrate binding site [chemical binding]; other site 762550001396 dimer interface [polypeptide binding]; other site 762550001397 catalytic triad [active] 762550001398 competence damage-inducible protein A; Provisional; Region: PRK00549 762550001399 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 762550001400 putative MPT binding site; other site 762550001401 Competence-damaged protein; Region: CinA; cl00666 762550001402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001403 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762550001404 NAD(P) binding site [chemical binding]; other site 762550001405 active site 762550001406 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 762550001407 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 762550001408 dimer interface [polypeptide binding]; other site 762550001409 active site 762550001410 metal binding site [ion binding]; metal-binding site 762550001411 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 762550001412 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001413 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550001414 Walker A/P-loop; other site 762550001415 ATP binding site [chemical binding]; other site 762550001416 Q-loop/lid; other site 762550001417 ABC transporter signature motif; other site 762550001418 Walker B; other site 762550001419 D-loop; other site 762550001420 H-loop/switch region; other site 762550001421 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001422 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550001423 Walker A/P-loop; other site 762550001424 ATP binding site [chemical binding]; other site 762550001425 Q-loop/lid; other site 762550001426 ABC transporter signature motif; other site 762550001427 Walker B; other site 762550001428 D-loop; other site 762550001429 H-loop/switch region; other site 762550001430 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 762550001431 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 762550001432 folate binding site [chemical binding]; other site 762550001433 NADP+ binding site [chemical binding]; other site 762550001434 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 762550001435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550001436 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762550001437 tetramer interfaces [polypeptide binding]; other site 762550001438 binuclear metal-binding site [ion binding]; other site 762550001439 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 762550001440 active site 762550001441 dimer interface [polypeptide binding]; other site 762550001442 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550001443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001444 DNA-binding site [nucleotide binding]; DNA binding site 762550001445 UTRA domain; Region: UTRA; cl06649 762550001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 762550001447 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 762550001448 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 762550001449 Walker A/P-loop; other site 762550001450 ATP binding site [chemical binding]; other site 762550001451 Q-loop/lid; other site 762550001452 ABC transporter signature motif; other site 762550001453 Walker B; other site 762550001454 D-loop; other site 762550001455 H-loop/switch region; other site 762550001456 NIL domain; Region: NIL; pfam09383 762550001457 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 762550001458 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 762550001459 metal binding site [ion binding]; metal-binding site 762550001460 dimer interface [polypeptide binding]; other site 762550001461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001463 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 762550001464 Predicted membrane protein [Function unknown]; Region: COG4907 762550001465 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 762550001466 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762550001467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550001468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550001469 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762550001470 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762550001471 metal binding site 2 [ion binding]; metal-binding site 762550001472 putative DNA binding helix; other site 762550001473 metal binding site 1 [ion binding]; metal-binding site 762550001474 dimer interface [polypeptide binding]; other site 762550001475 structural Zn2+ binding site [ion binding]; other site 762550001476 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762550001477 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762550001478 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 762550001479 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 762550001480 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762550001481 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762550001482 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762550001483 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762550001484 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 762550001485 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762550001486 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 762550001487 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 762550001488 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 762550001489 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762550001490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550001491 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762550001492 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 762550001493 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 762550001494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550001495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550001496 elongation factor P; Validated; Region: PRK00529 762550001497 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762550001498 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 762550001499 RNA binding site [nucleotide binding]; other site 762550001500 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 762550001501 RNA binding site [nucleotide binding]; other site 762550001502 Protein of unknown function (DUF322); Region: DUF322; cl00574 762550001503 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 762550001504 putative RNA binding site [nucleotide binding]; other site 762550001505 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762550001506 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 762550001507 active site 762550001508 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 762550001509 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 762550001510 putative active site [active] 762550001511 putative metal binding site [ion binding]; other site 762550001512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550001513 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 762550001514 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 762550001515 intersubunit interface [polypeptide binding]; other site 762550001516 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001517 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 762550001518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 762550001519 pur operon repressor; Provisional; Region: PRK09213 762550001520 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 762550001521 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550001522 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 762550001523 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762550001524 Substrate binding site [chemical binding]; other site 762550001525 Mg++ binding site [ion binding]; other site 762550001526 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762550001527 active site 762550001528 substrate binding site [chemical binding]; other site 762550001529 CoA binding site [chemical binding]; other site 762550001530 SLBB domain; Region: SLBB; pfam10531 762550001531 comEA protein; Region: comE; TIGR01259 762550001532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 762550001533 Competence protein; Region: Competence; cl00471 762550001534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550001535 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 762550001536 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762550001537 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 762550001538 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 762550001539 16S/18S rRNA binding site [nucleotide binding]; other site 762550001540 S13e-L30e interaction site [polypeptide binding]; other site 762550001541 25S rRNA binding site [nucleotide binding]; other site 762550001542 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 762550001543 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762550001544 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 762550001545 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762550001546 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762550001547 GatB domain; Region: GatB_Yqey; cl11497 762550001548 putative lipid kinase; Reviewed; Region: PRK13055 762550001549 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 762550001550 TRAM domain; Region: TRAM; cl01282 762550001551 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550001552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550001553 CTP synthetase; Validated; Region: pyrG; PRK05380 762550001554 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 762550001555 Catalytic site [active] 762550001556 Active site [active] 762550001557 UTP binding site [chemical binding]; other site 762550001558 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762550001559 active site 762550001560 putative oxyanion hole; other site 762550001561 catalytic triad [active] 762550001562 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762550001563 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 762550001564 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762550001565 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 762550001566 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762550001567 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762550001568 Walker A/P-loop; other site 762550001569 ATP binding site [chemical binding]; other site 762550001570 Q-loop/lid; other site 762550001571 ABC transporter signature motif; other site 762550001572 Walker B; other site 762550001573 D-loop; other site 762550001574 H-loop/switch region; other site 762550001575 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762550001576 GTPase CgtA; Reviewed; Region: obgE; PRK12297 762550001577 GTP1/OBG; Region: GTP1_OBG; pfam01018 762550001578 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 762550001579 G1 box; other site 762550001580 GTP/Mg2+ binding site [chemical binding]; other site 762550001581 Switch I region; other site 762550001582 G2 box; other site 762550001583 G3 box; other site 762550001584 Switch II region; other site 762550001585 G4 box; other site 762550001586 G5 box; other site 762550001587 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 762550001588 acetolactate synthase; Reviewed; Region: PRK08617 762550001589 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762550001590 PYR/PP interface [polypeptide binding]; other site 762550001591 dimer interface [polypeptide binding]; other site 762550001592 TPP binding site [chemical binding]; other site 762550001593 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762550001594 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 762550001595 TPP-binding site [chemical binding]; other site 762550001596 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 762550001597 Class III ribonucleotide reductase; Region: RNR_III; cd01675 762550001598 effector binding site; other site 762550001599 active site 762550001600 Zn binding site [ion binding]; other site 762550001601 glycine loop; other site 762550001602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 762550001603 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 762550001604 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 762550001605 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 762550001606 Walker A/P-loop; other site 762550001607 ATP binding site [chemical binding]; other site 762550001608 Q-loop/lid; other site 762550001609 ABC transporter signature motif; other site 762550001610 Walker B; other site 762550001611 D-loop; other site 762550001612 H-loop/switch region; other site 762550001613 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762550001614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550001615 active site 762550001616 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762550001617 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762550001618 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 762550001619 Ligand binding site [chemical binding]; other site 762550001620 Putative Catalytic site [active] 762550001621 DXD motif; other site 762550001622 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 762550001623 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762550001624 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762550001625 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762550001626 Probable Catalytic site [active] 762550001627 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 762550001628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762550001629 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550001630 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 762550001631 SecY translocase; Region: SecY; pfam00344 762550001632 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 762550001633 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550001634 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550001635 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762550001636 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 762550001637 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 762550001638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 762550001639 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762550001640 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550001641 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 762550001642 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550001643 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 762550001644 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 762550001645 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550001646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762550001647 active site 762550001648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550001649 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762550001650 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762550001651 dimerization interface [polypeptide binding]; other site 762550001652 active site 762550001653 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 762550001654 catalytic motif [active] 762550001655 Zn binding site [ion binding]; other site 762550001656 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 762550001657 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762550001658 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762550001659 homodimer interface [polypeptide binding]; other site 762550001660 NADP binding site [chemical binding]; other site 762550001661 substrate binding site [chemical binding]; other site 762550001662 BioY family; Region: BioY; cl00560 762550001663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001664 DNA-binding site [nucleotide binding]; DNA binding site 762550001665 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550001666 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 762550001667 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 762550001668 Walker A/P-loop; other site 762550001669 ATP binding site [chemical binding]; other site 762550001670 Q-loop/lid; other site 762550001671 ABC transporter signature motif; other site 762550001672 Walker B; other site 762550001673 D-loop; other site 762550001674 H-loop/switch region; other site 762550001675 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 762550001676 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762550001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550001678 dimer interface [polypeptide binding]; other site 762550001679 conserved gate region; other site 762550001680 putative PBP binding loops; other site 762550001681 ABC-ATPase subunit interface; other site 762550001682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001683 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762550001684 putative transporter; Provisional; Region: PRK11462 762550001685 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762550001686 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 762550001687 HPr interaction site; other site 762550001688 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550001689 active site 762550001690 phosphorylation site [posttranslational modification] 762550001691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550001692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl02583 762550001693 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550001694 galactokinase; Provisional; Region: PRK05322 762550001695 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 762550001696 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 762550001697 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550001698 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 762550001699 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 762550001700 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 762550001701 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 762550001702 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 762550001703 active site 762550001704 catalytic residues [active] 762550001705 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 762550001706 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762550001707 domain; Region: Glyco_hydro_2; pfam00703 762550001708 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 762550001709 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 762550001710 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762550001711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762550001712 active site 762550001713 catalytic tetrad [active] 762550001714 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762550001715 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 762550001716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550001717 Walker A/P-loop; other site 762550001718 ATP binding site [chemical binding]; other site 762550001719 Q-loop/lid; other site 762550001720 ABC transporter signature motif; other site 762550001721 Walker B; other site 762550001722 D-loop; other site 762550001723 H-loop/switch region; other site 762550001724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001725 non-specific DNA binding site [nucleotide binding]; other site 762550001726 salt bridge; other site 762550001727 sequence-specific DNA binding site [nucleotide binding]; other site 762550001728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550001729 Domain of unknown function (DUF955); Region: DUF955; cl01076 762550001730 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762550001731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550001732 active site 762550001733 motif I; other site 762550001734 motif II; other site 762550001735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001736 non-specific DNA binding site [nucleotide binding]; other site 762550001737 salt bridge; other site 762550001738 sequence-specific DNA binding site [nucleotide binding]; other site 762550001739 RNA polymerase sigma factor; Provisional; Region: PRK12519 762550001740 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 762550001741 polymerase nucleotide-binding site; other site 762550001742 DNA-binding residues [nucleotide binding]; DNA binding site 762550001743 nucleotide binding site [chemical binding]; other site 762550001744 primase nucleotide-binding site [nucleotide binding]; other site 762550001745 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 762550001746 D5 N terminal like; Region: D5_N; pfam08706 762550001747 C-terminal domain; Region: primase_Cterm; TIGR01613 762550001748 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762550001749 Phage integrase family; Region: Phage_integrase; pfam00589 762550001750 Int/Topo IB signature motif; other site 762550001751 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 762550001752 putative deacylase active site [active] 762550001753 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 762550001754 PQ loop repeat; Region: PQ-loop; cl12056 762550001755 VanW like protein; Region: VanW; pfam04294 762550001756 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 762550001757 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762550001758 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 762550001759 NAD(P) binding site [chemical binding]; other site 762550001760 catalytic residues [active] 762550001761 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762550001762 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 762550001763 generic binding surface II; other site 762550001764 ssDNA binding site; other site 762550001765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550001766 ATP binding site [chemical binding]; other site 762550001767 putative Mg++ binding site [ion binding]; other site 762550001768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001769 nucleotide binding region [chemical binding]; other site 762550001770 ATP-binding site [chemical binding]; other site 762550001771 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762550001772 MutS domain I; Region: MutS_I; pfam01624 762550001773 MutS domain II; Region: MutS_II; pfam05188 762550001774 MutS family domain IV; Region: MutS_IV; pfam05190 762550001775 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 762550001776 Walker A/P-loop; other site 762550001777 ATP binding site [chemical binding]; other site 762550001778 Q-loop/lid; other site 762550001779 ABC transporter signature motif; other site 762550001780 Walker B; other site 762550001781 D-loop; other site 762550001782 H-loop/switch region; other site 762550001783 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762550001784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001785 ATP binding site [chemical binding]; other site 762550001786 Mg2+ binding site [ion binding]; other site 762550001787 G-X-G motif; other site 762550001788 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 762550001789 ATP binding site [chemical binding]; other site 762550001790 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 762550001791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 762550001792 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762550001793 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762550001794 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762550001795 active site 762550001796 multimer interface [polypeptide binding]; other site 762550001797 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 762550001798 FAD binding domain; Region: FAD_binding_4; pfam01565 762550001799 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762550001800 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 762550001801 Uncharacterized conserved protein [Function unknown]; Region: COG1624 762550001802 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 762550001803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 762550001804 YbbR-like protein; Region: YbbR; pfam07949 762550001805 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 762550001806 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 762550001807 active site 762550001808 substrate binding site [chemical binding]; other site 762550001809 metal binding site [ion binding]; metal-binding site 762550001810 ribonuclease III; Reviewed; Region: rnc; PRK00102 762550001811 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 762550001812 dimerization interface [polypeptide binding]; other site 762550001813 active site 762550001814 metal binding site [ion binding]; metal-binding site 762550001815 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 762550001816 dsRNA binding site [nucleotide binding]; other site 762550001817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762550001818 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 762550001819 Walker A/P-loop; other site 762550001820 ATP binding site [chemical binding]; other site 762550001821 Q-loop/lid; other site 762550001822 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 762550001823 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 762550001824 Q-loop/lid; other site 762550001825 ABC transporter signature motif; other site 762550001826 Walker B; other site 762550001827 D-loop; other site 762550001828 H-loop/switch region; other site 762550001829 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762550001830 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762550001831 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762550001832 P loop; other site 762550001833 GTP binding site [chemical binding]; other site 762550001834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762550001835 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 762550001836 signal recognition particle protein; Provisional; Region: PRK10867 762550001837 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762550001838 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762550001839 P loop; other site 762550001840 GTP binding site [chemical binding]; other site 762550001841 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762550001842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550001843 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550001844 active site 762550001845 motif I; other site 762550001846 motif II; other site 762550001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550001848 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550001849 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762550001850 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 762550001851 P-loop; other site 762550001852 active site 762550001853 phosphorylation site [posttranslational modification] 762550001854 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 762550001855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550001856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550001857 PRD domain; Region: PRD; pfam00874 762550001858 PRD domain; Region: PRD; pfam00874 762550001859 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 762550001860 P-loop; other site 762550001861 active site 762550001862 phosphorylation site [posttranslational modification] 762550001863 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 762550001864 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550001865 methionine cluster; other site 762550001866 active site 762550001867 phosphorylation site [posttranslational modification] 762550001868 metal binding site [ion binding]; metal-binding site 762550001869 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550001870 histidinol-phosphatase; Reviewed; Region: PRK08123 762550001871 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 762550001872 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 762550001873 dimer interface [polypeptide binding]; other site 762550001874 motif 1; other site 762550001875 active site 762550001876 motif 2; other site 762550001877 motif 3; other site 762550001878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001879 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 762550001880 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 762550001881 NAD binding site [chemical binding]; other site 762550001882 dimerization interface [polypeptide binding]; other site 762550001883 product binding site; other site 762550001884 substrate binding site [chemical binding]; other site 762550001885 zinc binding site [ion binding]; other site 762550001886 catalytic residues [active] 762550001887 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762550001888 putative active site pocket [active] 762550001889 4-fold oligomerization interface [polypeptide binding]; other site 762550001890 metal binding residues [ion binding]; metal-binding site 762550001891 3-fold/trimer interface [polypeptide binding]; other site 762550001892 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 762550001893 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 762550001894 catalytic residues [active] 762550001895 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 762550001896 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 762550001897 substrate binding site [chemical binding]; other site 762550001898 glutamase interaction surface [polypeptide binding]; other site 762550001899 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 762550001900 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 762550001901 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 762550001902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550001903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550001904 homodimer interface [polypeptide binding]; other site 762550001905 catalytic residue [active] 762550001906 adenylosuccinate synthetase; Provisional; Region: PRK01117 762550001907 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 762550001908 GDP-binding site [chemical binding]; other site 762550001909 ACT binding site; other site 762550001910 IMP binding site; other site 762550001911 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762550001912 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 762550001913 Thymidine kinase; Region: TK; cl00631 762550001914 Uncharacterized conserved protein [Function unknown]; Region: COG3410 762550001915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001916 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762550001917 Walker A motif; other site 762550001918 ATP binding site [chemical binding]; other site 762550001919 Walker B motif; other site 762550001920 arginine finger; other site 762550001921 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 762550001922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550001923 Walker A motif; other site 762550001924 ATP binding site [chemical binding]; other site 762550001925 Walker B motif; other site 762550001926 arginine finger; other site 762550001927 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550001928 rod shape-determining protein MreB; Provisional; Region: PRK13927 762550001929 Cell division protein FtsA; Region: FtsA; cl11496 762550001930 rod shape-determining protein MreC; Region: MreC; pfam04085 762550001931 rod shape-determining protein MreD; Region: MreD; cl01087 762550001932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550001933 dimer interface [polypeptide binding]; other site 762550001934 conserved gate region; other site 762550001935 putative PBP binding loops; other site 762550001936 ABC-ATPase subunit interface; other site 762550001937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550001938 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550001939 Walker A/P-loop; other site 762550001940 ATP binding site [chemical binding]; other site 762550001941 Q-loop/lid; other site 762550001942 ABC transporter signature motif; other site 762550001943 Walker B; other site 762550001944 D-loop; other site 762550001945 H-loop/switch region; other site 762550001946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550001947 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550001948 substrate binding pocket [chemical binding]; other site 762550001949 membrane-bound complex binding site; other site 762550001950 hinge residues; other site 762550001951 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 762550001952 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762550001953 putative active site [active] 762550001954 catalytic site [active] 762550001955 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 762550001956 putative active site [active] 762550001957 catalytic site [active] 762550001958 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762550001959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762550001960 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762550001961 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762550001962 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762550001963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550001964 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762550001965 recombinase A; Provisional; Region: recA; PRK09354 762550001966 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762550001967 hexamer interface [polypeptide binding]; other site 762550001968 Walker A motif; other site 762550001969 ATP binding site [chemical binding]; other site 762550001970 Walker B motif; other site 762550001971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550001972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550001973 active site 762550001974 phosphorylation site [posttranslational modification] 762550001975 intermolecular recognition site; other site 762550001976 dimerization interface [polypeptide binding]; other site 762550001977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550001978 DNA binding site [nucleotide binding] 762550001979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001980 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762550001981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762550001982 dimer interface [polypeptide binding]; other site 762550001983 phosphorylation site [posttranslational modification] 762550001984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001985 ATP binding site [chemical binding]; other site 762550001986 Mg2+ binding site [ion binding]; other site 762550001987 G-X-G motif; other site 762550001988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550001989 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 762550001990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550001991 dimer interface [polypeptide binding]; other site 762550001992 conserved gate region; other site 762550001993 putative PBP binding loops; other site 762550001994 ABC-ATPase subunit interface; other site 762550001995 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 762550001996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550001997 dimer interface [polypeptide binding]; other site 762550001998 conserved gate region; other site 762550001999 putative PBP binding loops; other site 762550002000 ABC-ATPase subunit interface; other site 762550002001 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 762550002002 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 762550002003 Walker A/P-loop; other site 762550002004 ATP binding site [chemical binding]; other site 762550002005 Q-loop/lid; other site 762550002006 ABC transporter signature motif; other site 762550002007 Walker B; other site 762550002008 D-loop; other site 762550002009 H-loop/switch region; other site 762550002010 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 762550002011 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 762550002012 Walker A/P-loop; other site 762550002013 ATP binding site [chemical binding]; other site 762550002014 Q-loop/lid; other site 762550002015 ABC transporter signature motif; other site 762550002016 Walker B; other site 762550002017 D-loop; other site 762550002018 H-loop/switch region; other site 762550002019 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 762550002020 PhoU domain; Region: PhoU; pfam01895 762550002021 PhoU domain; Region: PhoU; pfam01895 762550002022 Membrane protein of unknown function; Region: DUF360; cl00850 762550002023 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762550002024 DRTGG domain; Region: DRTGG; cl12147 762550002025 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 762550002026 Hpr binding site; other site 762550002027 active site 762550002028 homohexamer subunit interaction site [polypeptide binding]; other site 762550002029 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762550002030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002031 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762550002032 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762550002033 active site 762550002034 tetramer interface [polypeptide binding]; other site 762550002035 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762550002036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550002037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550002038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550002040 putative substrate translocation pore; other site 762550002041 sucrose phosphorylase; Provisional; Region: PRK13840 762550002042 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550002043 potential frameshift: common BLAST hit: gi|170017597|ref|YP_001728516.1| DedA family protein 762550002044 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762550002045 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 762550002046 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 762550002047 active site 762550002048 substrate binding site [chemical binding]; other site 762550002049 metal binding site [ion binding]; metal-binding site 762550002050 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 762550002051 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762550002052 active site 762550002053 DNA polymerase IV; Validated; Region: PRK02406 762550002054 DNA binding site [nucleotide binding] 762550002055 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 762550002056 DHH family; Region: DHH; pfam01368 762550002057 DHHA1 domain; Region: DHHA1; pfam02272 762550002058 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762550002059 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762550002060 ATP binding site [chemical binding]; other site 762550002061 Mg++ binding site [ion binding]; other site 762550002062 motif III; other site 762550002063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550002064 nucleotide binding region [chemical binding]; other site 762550002065 ATP-binding site [chemical binding]; other site 762550002066 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 762550002067 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550002068 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 762550002069 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762550002070 MBOAT family; Region: MBOAT; cl00738 762550002071 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 762550002072 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762550002073 DltD N-terminal region; Region: DltD_N; pfam04915 762550002074 DltD central region; Region: DltD_M; pfam04918 762550002075 DltD C-terminal region; Region: DltD_C; pfam04914 762550002076 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 762550002077 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 762550002078 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 762550002079 active site 762550002080 dimerization interface [polypeptide binding]; other site 762550002081 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 762550002082 active site 762550002083 metal binding site [ion binding]; metal-binding site 762550002084 homotetramer interface [polypeptide binding]; other site 762550002085 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762550002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550002087 Walker A motif; other site 762550002088 ATP binding site [chemical binding]; other site 762550002089 Walker B motif; other site 762550002090 arginine finger; other site 762550002091 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762550002092 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 762550002093 putative active site [active] 762550002094 putative metal binding site [ion binding]; other site 762550002095 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 762550002096 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762550002097 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762550002098 RuvA N terminal domain; Region: RuvA_N; pfam01330 762550002099 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 762550002100 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762550002101 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 762550002102 Substrate-binding site [chemical binding]; other site 762550002103 Substrate specificity [chemical binding]; other site 762550002104 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 762550002105 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 762550002106 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 762550002107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002108 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 762550002109 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 762550002110 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 762550002111 putative substrate binding site [chemical binding]; other site 762550002112 putative ATP binding site [chemical binding]; other site 762550002113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762550002114 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 762550002115 active site 762550002116 phosphorylation site [posttranslational modification] 762550002117 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 762550002118 P-loop; other site 762550002119 active site 762550002120 phosphorylation site [posttranslational modification] 762550002121 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550002122 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762550002123 DNA binding site [nucleotide binding] 762550002124 active site 762550002125 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762550002126 RimM N-terminal domain; Region: RimM; pfam01782 762550002127 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 762550002128 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 762550002129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002130 non-specific DNA binding site [nucleotide binding]; other site 762550002131 salt bridge; other site 762550002132 sequence-specific DNA binding site [nucleotide binding]; other site 762550002133 C-terminal domain; Region: RGG_Cterm; TIGR01716 762550002134 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550002135 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762550002136 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762550002137 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550002138 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550002139 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 762550002140 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002141 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002142 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 762550002143 Chain length determinant protein; Region: Wzz; cl01623 762550002144 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 762550002145 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 762550002146 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 762550002147 Nucleotide binding site [chemical binding]; other site 762550002148 Bacterial sugar transferase; Region: Bac_transf; cl00939 762550002149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550002150 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 762550002151 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762550002152 putative ADP-binding pocket [chemical binding]; other site 762550002153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550002154 active site 762550002155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762550002156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550002157 active site 762550002158 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762550002159 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 762550002160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002161 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762550002162 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762550002163 NADP binding site [chemical binding]; other site 762550002164 active site 762550002165 putative substrate binding site [chemical binding]; other site 762550002166 Uncharacterized conserved protein [Function unknown]; Region: COG2966 762550002167 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 762550002168 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 762550002169 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 762550002170 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762550002171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002172 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762550002173 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 762550002174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550002175 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 762550002176 DHH family; Region: DHH; pfam01368 762550002177 DHHA1 domain; Region: DHHA1; pfam02272 762550002178 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 762550002179 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550002180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762550002181 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762550002182 synthetase active site [active] 762550002183 NTP binding site [chemical binding]; other site 762550002184 metal binding site [ion binding]; metal-binding site 762550002185 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 762550002186 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762550002187 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 762550002188 active site 762550002189 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762550002190 MgtE intracellular N domain; Region: MgtE_N; cl15244 762550002191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762550002192 Divalent cation transporter; Region: MgtE; cl00786 762550002193 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550002194 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 762550002195 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 762550002196 ANP binding site [chemical binding]; other site 762550002197 Substrate Binding Site II [chemical binding]; other site 762550002198 Substrate Binding Site I [chemical binding]; other site 762550002199 argininosuccinate lyase; Provisional; Region: PRK00855 762550002200 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762550002201 active sites [active] 762550002202 tetramer interface [polypeptide binding]; other site 762550002203 ornithine carbamoyltransferase; Validated; Region: PRK02102 762550002204 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762550002205 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762550002206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002207 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550002208 putative substrate translocation pore; other site 762550002209 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 762550002210 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 762550002211 metal binding site [ion binding]; metal-binding site 762550002212 dimer interface [polypeptide binding]; other site 762550002213 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 762550002214 Domain of unknown function (DUF814); Region: DUF814; pfam05670 762550002215 CutC family; Region: CutC; cl01218 762550002216 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 762550002217 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762550002218 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 762550002219 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762550002220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002221 non-specific DNA binding site [nucleotide binding]; other site 762550002222 salt bridge; other site 762550002223 sequence-specific DNA binding site [nucleotide binding]; other site 762550002224 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 762550002225 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 762550002226 active site 762550002227 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762550002228 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762550002229 active site 762550002230 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550002231 substrate binding site [chemical binding]; other site 762550002232 catalytic residues [active] 762550002233 dimer interface [polypeptide binding]; other site 762550002234 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 762550002235 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 762550002236 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762550002237 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762550002238 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762550002239 M28, and M42; Region: Zinc_peptidase_like; cl14876 762550002240 metal binding site [ion binding]; metal-binding site 762550002241 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762550002242 dihydrodipicolinate synthase; Region: dapA; TIGR00674 762550002243 dimer interface [polypeptide binding]; other site 762550002244 active site 762550002245 catalytic residue [active] 762550002246 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762550002247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002248 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762550002249 RecX family; Region: RecX; cl00936 762550002250 Protein of unknown function (DUF402); Region: DUF402; cl00979 762550002251 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 762550002252 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762550002253 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 762550002254 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 762550002255 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762550002256 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762550002257 Rhomboid family; Region: Rhomboid; cl11446 762550002258 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 762550002259 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 762550002260 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550002261 methionine aminopeptidase; Reviewed; Region: PRK07281 762550002262 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762550002263 active site 762550002264 Bacterial sugar transferase; Region: Bac_transf; cl00939 762550002265 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550002266 NlpC/P60 family; Region: NLPC_P60; cl11438 762550002267 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 762550002268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550002269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550002270 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762550002271 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762550002272 Ligand binding site [chemical binding]; other site 762550002273 Putative Catalytic site [active] 762550002274 DXD motif; other site 762550002275 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550002276 active site 762550002277 nucleotide binding site [chemical binding]; other site 762550002278 HIGH motif; other site 762550002279 KMSKS motif; other site 762550002280 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762550002281 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762550002282 Probable Catalytic site [active] 762550002283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762550002284 DNA-binding site [nucleotide binding]; DNA binding site 762550002285 RNA-binding motif; other site 762550002286 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 762550002287 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 762550002288 dimer interface [polypeptide binding]; other site 762550002289 ADP-ribose binding site [chemical binding]; other site 762550002290 active site 762550002291 nudix motif; other site 762550002292 metal binding site [ion binding]; metal-binding site 762550002293 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 762550002294 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762550002295 putative tRNA-binding site [nucleotide binding]; other site 762550002296 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762550002297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762550002298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550002299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762550002300 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 762550002301 DNA polymerase I; Provisional; Region: PRK05755 762550002302 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762550002303 active site 762550002304 metal binding site 1 [ion binding]; metal-binding site 762550002305 putative 5' ssDNA interaction site; other site 762550002306 metal binding site 3; metal-binding site 762550002307 metal binding site 2 [ion binding]; metal-binding site 762550002308 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762550002309 putative DNA binding site [nucleotide binding]; other site 762550002310 putative metal binding site [ion binding]; other site 762550002311 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 762550002312 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762550002313 active site 762550002314 DNA binding site [nucleotide binding] 762550002315 catalytic site [active] 762550002316 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762550002317 DNA binding residues [nucleotide binding] 762550002318 putative dimer interface [polypeptide binding]; other site 762550002319 glutamine synthetase, type I; Region: GlnA; TIGR00653 762550002320 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762550002321 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762550002322 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550002323 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550002324 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 762550002325 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762550002326 active site 1 [active] 762550002327 dimer interface [polypeptide binding]; other site 762550002328 hexamer interface [polypeptide binding]; other site 762550002329 active site 2 [active] 762550002330 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550002331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550002332 DNA binding site [nucleotide binding] 762550002333 domain linker motif; other site 762550002334 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550002335 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550002336 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 762550002337 active site turn [active] 762550002338 phosphorylation site [posttranslational modification] 762550002339 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550002340 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 762550002341 HPr interaction site; other site 762550002342 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550002343 active site 762550002344 phosphorylation site [posttranslational modification] 762550002345 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762550002346 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550002347 substrate binding [chemical binding]; other site 762550002348 active site 762550002349 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 762550002350 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550002351 active site 762550002352 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 762550002353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550002354 RNA binding surface [nucleotide binding]; other site 762550002355 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 762550002356 active site 762550002357 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550002358 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 762550002359 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 762550002360 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762550002361 catalytic site [active] 762550002362 subunit interface [polypeptide binding]; other site 762550002363 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 762550002364 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550002365 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762550002366 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 762550002367 drug efflux system protein MdtG; Provisional; Region: PRK09874 762550002368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002369 putative substrate translocation pore; other site 762550002370 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762550002371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550002372 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762550002373 synthetase active site [active] 762550002374 NTP binding site [chemical binding]; other site 762550002375 metal binding site [ion binding]; metal-binding site 762550002376 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 762550002377 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762550002378 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 762550002379 putative active site [active] 762550002380 dimerization interface [polypeptide binding]; other site 762550002381 putative tRNAtyr binding site [nucleotide binding]; other site 762550002382 Domain of unknown function (DUF205); Region: DUF205; cl00410 762550002383 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762550002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 762550002385 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 762550002386 anchoring element; other site 762550002387 dimer interface [polypeptide binding]; other site 762550002388 ATP binding site [chemical binding]; other site 762550002389 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762550002390 active site 762550002391 putative metal-binding site [ion binding]; other site 762550002392 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762550002393 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762550002394 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 762550002395 CAP-like domain; other site 762550002396 Active site [active] 762550002397 primary dimer interface [polypeptide binding]; other site 762550002398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550002399 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 762550002400 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 762550002401 DHHA2 domain; Region: DHHA2; pfam02833 762550002402 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 762550002403 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 762550002404 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762550002405 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 762550002406 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 762550002407 Sm1 motif; other site 762550002408 D3 - B interaction site; other site 762550002409 D1 - D2 interaction site; other site 762550002410 Hfq - Hfq interaction site; other site 762550002411 RNA binding pocket [nucleotide binding]; other site 762550002412 Sm2 motif; other site 762550002413 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 762550002414 NusA N-terminal domain; Region: NusA_N; pfam08529 762550002415 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 762550002416 RNA binding site [nucleotide binding]; other site 762550002417 homodimer interface [polypeptide binding]; other site 762550002418 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762550002419 G-X-X-G motif; other site 762550002420 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 762550002421 putative RNA binding cleft [nucleotide binding]; other site 762550002422 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 762550002423 translation initiation factor IF-2; Region: IF-2; TIGR00487 762550002424 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762550002425 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 762550002426 G1 box; other site 762550002427 putative GEF interaction site [polypeptide binding]; other site 762550002428 GTP/Mg2+ binding site [chemical binding]; other site 762550002429 Switch I region; other site 762550002430 G2 box; other site 762550002431 G3 box; other site 762550002432 Switch II region; other site 762550002433 G4 box; other site 762550002434 G5 box; other site 762550002435 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 762550002436 Translation-initiation factor 2; Region: IF-2; pfam11987 762550002437 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 762550002438 Ribosome-binding factor A; Region: RBFA; cl00542 762550002439 aspartate aminotransferase; Provisional; Region: PRK08361 762550002440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550002442 homodimer interface [polypeptide binding]; other site 762550002443 catalytic residue [active] 762550002444 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 762550002445 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550002446 HPr interaction site; other site 762550002447 active site 762550002448 phosphorylation site [posttranslational modification] 762550002449 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 762550002450 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 762550002451 RNA binding site [nucleotide binding]; other site 762550002452 active site 762550002453 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762550002454 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762550002455 active site 762550002456 Riboflavin kinase; Region: Flavokinase; pfam01687 762550002457 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762550002458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002459 HrcA protein C terminal domain; Region: HrcA; pfam01628 762550002460 heat shock protein GrpE; Provisional; Region: PRK14140 762550002461 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 762550002462 dimer interface [polypeptide binding]; other site 762550002463 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762550002464 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762550002465 StbA protein; Region: StbA; pfam06406 762550002466 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 762550002467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 762550002468 HSP70 interaction site [polypeptide binding]; other site 762550002469 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 762550002470 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 762550002471 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 762550002472 active site 762550002473 catalytic residues [active] 762550002474 metal binding site [ion binding]; metal-binding site 762550002475 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 762550002476 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 762550002477 active site 762550002478 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 762550002479 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 762550002480 G1 box; other site 762550002481 putative GEF interaction site [polypeptide binding]; other site 762550002482 GTP/Mg2+ binding site [chemical binding]; other site 762550002483 Switch I region; other site 762550002484 G2 box; other site 762550002485 G3 box; other site 762550002486 Switch II region; other site 762550002487 G4 box; other site 762550002488 G5 box; other site 762550002489 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762550002490 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 762550002491 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 762550002492 active site 762550002493 catalytic triad [active] 762550002494 oxyanion hole [active] 762550002495 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762550002496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762550002497 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762550002498 active site 762550002499 metal binding site [ion binding]; metal-binding site 762550002500 DNA binding site [nucleotide binding] 762550002501 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762550002502 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762550002503 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 762550002504 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 762550002505 generic binding surface II; other site 762550002506 generic binding surface I; other site 762550002507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550002508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550002509 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 762550002510 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 762550002511 HIT family signature motif; other site 762550002512 catalytic residue [active] 762550002513 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550002514 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 762550002515 Walker A/P-loop; other site 762550002516 ATP binding site [chemical binding]; other site 762550002517 Q-loop/lid; other site 762550002518 ABC transporter signature motif; other site 762550002519 Walker B; other site 762550002520 D-loop; other site 762550002521 H-loop/switch region; other site 762550002522 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 762550002523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550002524 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 762550002525 Terminase small subunit; Region: Terminase_2; cl01513 762550002526 Phage terminase large subunit; Region: Terminase_3; cl12054 762550002527 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 762550002528 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 762550002529 MepB protein; Region: MepB; cl01985 762550002530 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 762550002531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550002532 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 762550002533 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 762550002534 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762550002535 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762550002536 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762550002537 active site 762550002538 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762550002539 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 762550002540 active site 762550002541 metal binding site [ion binding]; metal-binding site 762550002542 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762550002543 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 762550002544 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 762550002545 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 762550002546 homodimer interface [polypeptide binding]; other site 762550002547 substrate-cofactor binding pocket; other site 762550002548 catalytic residue [active] 762550002549 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550002550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002551 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 762550002552 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762550002553 putative active site [active] 762550002554 catalytic site [active] 762550002555 putative metal binding site [ion binding]; other site 762550002556 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 762550002557 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 762550002558 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 762550002559 FMN binding site [chemical binding]; other site 762550002560 active site 762550002561 catalytic residues [active] 762550002562 substrate binding site [chemical binding]; other site 762550002563 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 762550002564 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550002565 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762550002566 HicB family; Region: HicB; pfam05534 762550002567 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762550002568 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762550002569 Flavoprotein; Region: Flavoprotein; cl08021 762550002570 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 762550002571 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 762550002572 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 762550002573 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762550002574 active site 762550002575 HIGH motif; other site 762550002576 KMSK motif region; other site 762550002577 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 762550002578 tRNA binding surface [nucleotide binding]; other site 762550002579 anticodon binding site; other site 762550002580 Arginine repressor [Transcription]; Region: ArgR; COG1438 762550002581 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762550002582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762550002583 Transglycosylase; Region: Transgly; cl07896 762550002584 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 762550002585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762550002586 Protein of unknown function (DUF964); Region: DUF964; cl01483 762550002587 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762550002588 Catalytic site [active] 762550002589 Peptidase S26; Region: Peptidase_S26; pfam10502 762550002590 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762550002591 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 762550002592 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762550002593 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762550002594 dihydroorotase; Validated; Region: pyrC; PRK09357 762550002595 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 762550002596 active site 762550002597 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762550002598 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 762550002599 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762550002600 catalytic site [active] 762550002601 subunit interface [polypeptide binding]; other site 762550002602 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762550002603 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550002604 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550002605 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762550002606 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550002607 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550002608 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762550002609 IMP binding site; other site 762550002610 dimer interface [polypeptide binding]; other site 762550002611 interdomain contacts; other site 762550002612 partial ornithine binding site; other site 762550002613 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 762550002614 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 762550002615 heterodimer interface [polypeptide binding]; other site 762550002616 active site 762550002617 FMN binding site [chemical binding]; other site 762550002618 homodimer interface [polypeptide binding]; other site 762550002619 substrate binding site [chemical binding]; other site 762550002620 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 762550002621 active site 762550002622 dimer interface [polypeptide binding]; other site 762550002623 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550002624 LexA repressor; Validated; Region: PRK00215 762550002625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002626 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 762550002627 Catalytic site [active] 762550002628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762550002629 putative acyl-acceptor binding pocket; other site 762550002630 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 762550002631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550002632 S-adenosylmethionine binding site [chemical binding]; other site 762550002633 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 762550002634 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762550002635 rRNA interaction site [nucleotide binding]; other site 762550002636 S8 interaction site; other site 762550002637 putative laminin-1 binding site; other site 762550002638 elongation factor Ts; Provisional; Region: tsf; PRK09377 762550002639 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 762550002640 Elongation factor TS; Region: EF_TS; pfam00889 762550002641 Elongation factor TS; Region: EF_TS; pfam00889 762550002642 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 762550002643 putative nucleotide binding site [chemical binding]; other site 762550002644 uridine monophosphate binding site [chemical binding]; other site 762550002645 homohexameric interface [polypeptide binding]; other site 762550002646 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 762550002647 hinge region; other site 762550002648 Protein of unknown function (DUF805); Region: DUF805; cl01224 762550002649 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 762550002650 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550002651 motif 1; other site 762550002652 dimer interface [polypeptide binding]; other site 762550002653 active site 762550002654 motif 2; other site 762550002655 motif 3; other site 762550002656 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 762550002657 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 762550002658 putative oxidoreductase; Provisional; Region: PRK10206 762550002659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002660 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 762550002661 GTP-binding protein LepA; Provisional; Region: PRK05433 762550002662 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 762550002663 G1 box; other site 762550002664 putative GEF interaction site [polypeptide binding]; other site 762550002665 GTP/Mg2+ binding site [chemical binding]; other site 762550002666 Switch I region; other site 762550002667 G2 box; other site 762550002668 G3 box; other site 762550002669 Switch II region; other site 762550002670 G4 box; other site 762550002671 G5 box; other site 762550002672 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 762550002673 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762550002674 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762550002675 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762550002676 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762550002677 putative NAD(P) binding site [chemical binding]; other site 762550002678 dimer interface [polypeptide binding]; other site 762550002679 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 762550002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550002681 S-adenosylmethionine binding site [chemical binding]; other site 762550002682 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 762550002683 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 762550002684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550002685 Walker A/P-loop; other site 762550002686 ATP binding site [chemical binding]; other site 762550002687 Q-loop/lid; other site 762550002688 ABC transporter signature motif; other site 762550002689 Walker B; other site 762550002690 D-loop; other site 762550002691 H-loop/switch region; other site 762550002692 ABC transporter; Region: ABC_tran_2; pfam12848 762550002693 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550002694 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 762550002695 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 762550002696 dimer interface [polypeptide binding]; other site 762550002697 active site 762550002698 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 762550002699 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 762550002700 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 762550002701 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762550002702 DNA binding site [nucleotide binding] 762550002703 Int/Topo IB signature motif; other site 762550002704 active site 762550002705 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 762550002706 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 762550002707 active site 762550002708 catalytic residues [active] 762550002709 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 762550002710 active site 762550002711 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762550002712 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 762550002713 active site 762550002714 dimerization interface [polypeptide binding]; other site 762550002715 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762550002716 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762550002717 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 762550002718 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 762550002719 RNA binding site [nucleotide binding]; other site 762550002720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550002721 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550002722 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550002723 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 762550002724 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 762550002725 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550002726 dimer interface [polypeptide binding]; other site 762550002727 substrate binding site [chemical binding]; other site 762550002728 ATP binding site [chemical binding]; other site 762550002729 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 762550002730 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762550002731 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 762550002732 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 762550002733 dimer interface [polypeptide binding]; other site 762550002734 tetramer interface [polypeptide binding]; other site 762550002735 PYR/PP interface [polypeptide binding]; other site 762550002736 TPP binding site [chemical binding]; other site 762550002737 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 762550002738 TPP-binding site; other site 762550002739 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 762550002740 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 762550002741 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 762550002742 metal binding site [ion binding]; metal-binding site 762550002743 substrate binding pocket [chemical binding]; other site 762550002744 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 762550002745 dimer interface [polypeptide binding]; other site 762550002746 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 762550002747 active site 762550002748 metal binding site [ion binding]; metal-binding site 762550002749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550002750 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762550002751 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 762550002752 peptidase T; Region: peptidase-T; TIGR01882 762550002753 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 762550002754 metal binding site [ion binding]; metal-binding site 762550002755 dimer interface [polypeptide binding]; other site 762550002756 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 762550002757 active site 762550002758 catalytic triad [active] 762550002759 oxyanion hole [active] 762550002760 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 762550002761 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 762550002762 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 762550002763 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 762550002764 GTP/Mg2+ binding site [chemical binding]; other site 762550002765 G4 box; other site 762550002766 G5 box; other site 762550002767 G1 box; other site 762550002768 Switch I region; other site 762550002769 G2 box; other site 762550002770 G3 box; other site 762550002771 Switch II region; other site 762550002772 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762550002773 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550002774 active site 762550002775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762550002776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762550002777 ligand binding site [chemical binding]; other site 762550002778 flexible hinge region; other site 762550002779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002780 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 762550002781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550002782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550002783 Domain of unknown function DUF77; Region: DUF77; cl00307 762550002784 Protein of unknown function, DUF606; Region: DUF606; cl01273 762550002785 Protein of unknown function, DUF606; Region: DUF606; cl01273 762550002786 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762550002787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762550002788 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 762550002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550002790 S-adenosylmethionine binding site [chemical binding]; other site 762550002791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002792 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 762550002793 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 762550002794 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 762550002795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762550002796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550002797 active site 762550002798 catalytic tetrad [active] 762550002799 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 762550002800 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 762550002801 putative active site [active] 762550002802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 762550002803 NeuB family; Region: NeuB; cl00496 762550002804 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762550002805 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 762550002806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762550002807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550002809 dimerization interface [polypeptide binding]; other site 762550002810 malate dehydrogenase; Provisional; Region: PRK13529 762550002811 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762550002812 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 762550002813 NAD(P) binding site [chemical binding]; other site 762550002814 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 762550002815 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550002816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002817 putative substrate translocation pore; other site 762550002818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002819 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762550002820 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762550002821 active site 762550002822 metal binding site [ion binding]; metal-binding site 762550002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550002824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550002825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550002826 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550002827 Walker A/P-loop; other site 762550002828 ATP binding site [chemical binding]; other site 762550002829 Q-loop/lid; other site 762550002830 ABC transporter signature motif; other site 762550002831 Walker B; other site 762550002832 D-loop; other site 762550002833 H-loop/switch region; other site 762550002834 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 762550002835 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 762550002836 Protein of unknown function (DUF322); Region: DUF322; cl00574 762550002837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550002838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002839 putative substrate translocation pore; other site 762550002840 H+ Antiporter protein; Region: 2A0121; TIGR00900 762550002841 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 762550002842 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762550002843 NAD binding site [chemical binding]; other site 762550002844 catalytic residues [active] 762550002845 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550002846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002847 putative substrate translocation pore; other site 762550002848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550002849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550002850 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762550002851 conserved cys residue [active] 762550002852 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550002853 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762550002854 NAD(P) binding site [chemical binding]; other site 762550002855 SAP domain; Region: SAP; cl02640 762550002856 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 762550002857 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762550002858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762550002859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002860 non-specific DNA binding site [nucleotide binding]; other site 762550002861 salt bridge; other site 762550002862 sequence-specific DNA binding site [nucleotide binding]; other site 762550002863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002864 non-specific DNA binding site [nucleotide binding]; other site 762550002865 salt bridge; other site 762550002866 sequence-specific DNA binding site [nucleotide binding]; other site 762550002867 potential frameshift: common BLAST hit: gi|116618146|ref|YP_818517.1| transcriptional regulator 762550002868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550002869 potential frameshift: common BLAST hit: gi|170017219|ref|YP_001728138.1| transcriptional regulator 762550002870 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550002871 Integrase core domain; Region: rve; cl01316 762550002872 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 762550002873 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762550002874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550002875 ATP binding site [chemical binding]; other site 762550002876 putative Mg++ binding site [ion binding]; other site 762550002877 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 762550002878 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762550002879 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 762550002880 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762550002881 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762550002882 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762550002883 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 762550002884 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 762550002885 Uncharacterized conserved protein H4 (DUF2046); Region: DUF2046; pfam09755 762550002886 NlpC/P60 family; Region: NLPC_P60; cl11438 762550002887 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550002888 catalytic residues [active] 762550002889 AAA-like domain; Region: AAA_10; pfam12846 762550002890 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 762550002891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550002892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550002893 Replication initiation factor; Region: Rep_trans; pfam02486 762550002894 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550002895 Integrase core domain; Region: rve; cl01316 762550002896 DNA polymerase IV; Reviewed; Region: PRK03103 762550002897 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762550002898 active site 762550002899 DNA binding site [nucleotide binding] 762550002900 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 762550002901 putative dimer interface [polypeptide binding]; other site 762550002902 catalytic triad [active] 762550002903 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762550002904 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762550002905 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762550002906 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 762550002907 Walker A/P-loop; other site 762550002908 ATP binding site [chemical binding]; other site 762550002909 Q-loop/lid; other site 762550002910 ABC transporter signature motif; other site 762550002911 Walker B; other site 762550002912 D-loop; other site 762550002913 H-loop/switch region; other site 762550002914 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762550002915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002916 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550002917 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 762550002918 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 762550002919 NADP binding site [chemical binding]; other site 762550002920 homodimer interface [polypeptide binding]; other site 762550002921 active site 762550002922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550002923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550002924 DNA binding site [nucleotide binding] 762550002925 domain linker motif; other site 762550002926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550002927 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550002928 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002929 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762550002930 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550002931 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550002932 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002933 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002934 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002936 non-specific DNA binding site [nucleotide binding]; other site 762550002937 salt bridge; other site 762550002938 sequence-specific DNA binding site [nucleotide binding]; other site 762550002939 C-terminal domain; Region: RGG_Cterm; TIGR01716 762550002940 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 762550002941 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762550002942 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550002943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550002944 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762550002945 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762550002946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762550002947 active site 762550002948 catalytic tetrad [active] 762550002949 Domain of unknown function DUF20; Region: UPF0118; cl00465 762550002950 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 762550002951 catalytic residues [active] 762550002952 dimer interface [polypeptide binding]; other site 762550002953 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 762550002954 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762550002955 putative NAD(P) binding site [chemical binding]; other site 762550002956 catalytic Zn binding site [ion binding]; other site 762550002957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 762550002958 classical (c) SDRs; Region: SDR_c; cd05233 762550002959 NAD(P) binding site [chemical binding]; other site 762550002960 active site 762550002961 QueT transporter; Region: QueT; cl01932 762550002962 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 762550002963 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 762550002964 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762550002965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550002966 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762550002967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 762550002968 DNA binding residues [nucleotide binding] 762550002969 DNA primase; Validated; Region: dnaG; PRK05667 762550002970 CHC2 zinc finger; Region: zf-CHC2; cl02597 762550002971 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762550002972 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762550002973 active site 762550002974 metal binding site [ion binding]; metal-binding site 762550002975 interdomain interaction site; other site 762550002976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550002977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550002978 Coenzyme A binding pocket [chemical binding]; other site 762550002979 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550002980 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 762550002981 putative active site [active] 762550002982 DNA polymerase IV; Reviewed; Region: PRK03103 762550002983 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762550002984 active site 762550002985 DNA binding site [nucleotide binding] 762550002986 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 762550002987 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 762550002988 trimer interface [polypeptide binding]; other site 762550002989 active site 762550002990 substrate binding site [chemical binding]; other site 762550002991 CoA binding site [chemical binding]; other site 762550002992 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 762550002993 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 762550002994 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762550002995 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762550002996 DNA binding site [nucleotide binding] 762550002997 active site 762550002998 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762550002999 tetramer interface [polypeptide binding]; other site 762550003000 active site 762550003001 Mg2+/Mn2+ binding site [ion binding]; other site 762550003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550003003 active site 762550003004 motif I; other site 762550003005 motif II; other site 762550003006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003007 Walker A/P-loop; other site 762550003008 ATP binding site [chemical binding]; other site 762550003009 Q-loop/lid; other site 762550003010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003011 ABC transporter signature motif; other site 762550003012 Walker B; other site 762550003013 D-loop; other site 762550003014 H-loop/switch region; other site 762550003015 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762550003016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003017 Walker A/P-loop; other site 762550003018 ATP binding site [chemical binding]; other site 762550003019 Q-loop/lid; other site 762550003020 ABC transporter signature motif; other site 762550003021 Walker B; other site 762550003022 D-loop; other site 762550003023 H-loop/switch region; other site 762550003024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550003025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550003026 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550003027 putative transposase OrfB; Reviewed; Region: PHA02517 762550003028 Integrase core domain; Region: rve; cl01316 762550003029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550003030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762550003031 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 762550003032 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762550003033 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 762550003034 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550003035 putative peptidoglycan binding site; other site 762550003036 autolysin; Reviewed; Region: PRK06347 762550003037 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550003038 putative peptidoglycan binding site; other site 762550003039 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 762550003040 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 762550003041 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 762550003042 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 762550003043 Predicted membrane protein [Function unknown]; Region: COG2364 762550003044 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003045 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 762550003046 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 762550003047 Cl- selectivity filter; other site 762550003048 Cl- binding residues [ion binding]; other site 762550003049 pore gating glutamate residue; other site 762550003050 dimer interface [polypeptide binding]; other site 762550003051 H+/Cl- coupling transport residue; other site 762550003052 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550003053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003054 non-specific DNA binding site [nucleotide binding]; other site 762550003055 salt bridge; other site 762550003056 sequence-specific DNA binding site [nucleotide binding]; other site 762550003057 Cupin domain; Region: Cupin_2; cl09118 762550003058 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 762550003059 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 762550003060 PYR/PP interface [polypeptide binding]; other site 762550003061 tetramer interface [polypeptide binding]; other site 762550003062 dimer interface [polypeptide binding]; other site 762550003063 TPP binding site [chemical binding]; other site 762550003064 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762550003065 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 762550003066 TPP-binding site [chemical binding]; other site 762550003067 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003068 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550003069 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762550003070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550003071 Coenzyme A binding pocket [chemical binding]; other site 762550003072 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762550003073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550003074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762550003075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550003076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762550003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550003078 dimer interface [polypeptide binding]; other site 762550003079 conserved gate region; other site 762550003080 putative PBP binding loops; other site 762550003081 ABC-ATPase subunit interface; other site 762550003082 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 762550003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550003084 dimer interface [polypeptide binding]; other site 762550003085 conserved gate region; other site 762550003086 putative PBP binding loops; other site 762550003087 ABC-ATPase subunit interface; other site 762550003088 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762550003089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003090 Walker A/P-loop; other site 762550003091 ATP binding site [chemical binding]; other site 762550003092 Q-loop/lid; other site 762550003093 ABC transporter signature motif; other site 762550003094 Walker B; other site 762550003095 D-loop; other site 762550003096 H-loop/switch region; other site 762550003097 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 762550003098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003099 putative substrate translocation pore; other site 762550003100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003101 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 762550003102 Collagen binding domain; Region: Collagen_bind; pfam05737 762550003103 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 762550003104 putative Ca2+ binding sites [ion binding]; other site 762550003105 domain interaction interfaces; other site 762550003106 putative ligand binding motif; other site 762550003107 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 762550003108 N-glycosyltransferase; Provisional; Region: PRK11204 762550003109 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 762550003110 DXD motif; other site 762550003111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762550003112 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 762550003113 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 762550003114 legume lectins; Region: lectin_L-type; cl14058 762550003115 homotetramer interaction site [polypeptide binding]; other site 762550003116 carbohydrate binding site [chemical binding]; other site 762550003117 metal binding site [ion binding]; metal-binding site 762550003118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550003119 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762550003120 hydrophobic ligand binding site; other site 762550003121 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762550003122 MatE; Region: MatE; pfam01554 762550003123 MatE; Region: MatE; pfam01554 762550003124 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 762550003125 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 762550003126 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 762550003127 active site 762550003128 phosphorylation site [posttranslational modification] 762550003129 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 762550003130 active pocket/dimerization site; other site 762550003131 active site 762550003132 phosphorylation site [posttranslational modification] 762550003133 DNA topoisomerase I; Validated; Region: PRK05582 762550003134 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 762550003135 active site 762550003136 interdomain interaction site; other site 762550003137 putative metal-binding site [ion binding]; other site 762550003138 nucleotide binding site [chemical binding]; other site 762550003139 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 762550003140 domain I; other site 762550003141 DNA binding groove [nucleotide binding] 762550003142 phosphate binding site [ion binding]; other site 762550003143 domain II; other site 762550003144 domain III; other site 762550003145 nucleotide binding site [chemical binding]; other site 762550003146 catalytic site [active] 762550003147 domain IV; other site 762550003148 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 762550003149 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 762550003150 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 762550003151 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762550003152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003153 Walker A/P-loop; other site 762550003154 ATP binding site [chemical binding]; other site 762550003155 Q-loop/lid; other site 762550003156 ABC transporter signature motif; other site 762550003157 Walker B; other site 762550003158 D-loop; other site 762550003159 H-loop/switch region; other site 762550003160 ABC transporter; Region: ABC_tran_2; pfam12848 762550003161 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 762550003162 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 762550003163 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 762550003164 active site 762550003165 FMN binding site [chemical binding]; other site 762550003166 substrate binding site [chemical binding]; other site 762550003167 catalytic residues [active] 762550003168 homodimer interface [polypeptide binding]; other site 762550003169 Acetokinase family; Region: Acetate_kinase; cl01029 762550003170 Bacterial SH3 domain; Region: SH3_3; cl02551 762550003171 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762550003172 active site 762550003173 metal binding site [ion binding]; metal-binding site 762550003174 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 762550003175 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 762550003176 dimer interface [polypeptide binding]; other site 762550003177 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762550003178 active site 762550003179 folate binding site [chemical binding]; other site 762550003180 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762550003181 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 762550003182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550003183 catalytic residue [active] 762550003184 homoserine dehydrogenase; Provisional; Region: PRK06349 762550003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550003186 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762550003187 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762550003188 homoserine kinase; Provisional; Region: PRK01212 762550003189 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550003190 aspartate kinase; Reviewed; Region: PRK09034 762550003191 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 762550003192 putative catalytic residues [active] 762550003193 putative nucleotide binding site [chemical binding]; other site 762550003194 putative aspartate binding site [chemical binding]; other site 762550003195 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 762550003196 allosteric regulatory residue; other site 762550003197 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762550003198 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 762550003199 active site/substrate binding site [active] 762550003200 tetramer interface [polypeptide binding]; other site 762550003201 Recombination protein O N terminal; Region: RecO_N; pfam11967 762550003202 DNA repair protein RecO; Region: reco; TIGR00613 762550003203 Recombination protein O C terminal; Region: RecO_C; pfam02565 762550003204 GTPase Era; Reviewed; Region: era; PRK00089 762550003205 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 762550003206 G1 box; other site 762550003207 GTP/Mg2+ binding site [chemical binding]; other site 762550003208 Switch I region; other site 762550003209 G2 box; other site 762550003210 Switch II region; other site 762550003211 G3 box; other site 762550003212 G4 box; other site 762550003213 G5 box; other site 762550003214 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 762550003215 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 762550003216 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 762550003217 PhoH-like protein; Region: PhoH; cl12134 762550003218 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 762550003219 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 762550003220 pyruvate kinase; Provisional; Region: PRK05826 762550003221 domain interfaces; other site 762550003222 active site 762550003223 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 762550003224 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 762550003225 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 762550003226 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 762550003227 generic binding surface II; other site 762550003228 generic binding surface I; other site 762550003229 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 762550003230 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 762550003231 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 762550003232 active site 762550003233 catalytic residue [active] 762550003234 dimer interface [polypeptide binding]; other site 762550003235 Prephenate dehydratase; Region: PDT; pfam00800 762550003236 shikimate kinase; Reviewed; Region: aroK; PRK00131 762550003237 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 762550003238 ADP binding site [chemical binding]; other site 762550003239 magnesium binding site [ion binding]; other site 762550003240 putative shikimate binding site; other site 762550003241 Chorismate mutase type II; Region: CM_2; cl00693 762550003242 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 762550003243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550003244 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762550003245 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 762550003246 hinge; other site 762550003247 active site 762550003248 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762550003249 Tetramer interface [polypeptide binding]; other site 762550003250 Active site [active] 762550003251 FMN-binding site [chemical binding]; other site 762550003252 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762550003253 active site 762550003254 dimer interface [polypeptide binding]; other site 762550003255 metal binding site [ion binding]; metal-binding site 762550003256 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 762550003257 NeuB family; Region: NeuB; cl00496 762550003258 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762550003259 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762550003260 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762550003261 shikimate binding site; other site 762550003262 NAD(P) binding site [chemical binding]; other site 762550003263 transketolase; Reviewed; Region: PRK05899 762550003264 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762550003265 TPP-binding site [chemical binding]; other site 762550003266 dimer interface [polypeptide binding]; other site 762550003267 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762550003268 PYR/PP interface [polypeptide binding]; other site 762550003269 dimer interface [polypeptide binding]; other site 762550003270 TPP binding site [chemical binding]; other site 762550003271 CsbD-like; Region: CsbD; cl01272 762550003272 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 762550003273 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 762550003274 folate binding site [chemical binding]; other site 762550003275 NADP+ binding site [chemical binding]; other site 762550003276 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 762550003277 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762550003278 active site 762550003279 NTP binding site [chemical binding]; other site 762550003280 metal binding triad [ion binding]; metal-binding site 762550003281 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762550003282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762550003283 binding surface 762550003284 TPR motif; other site 762550003285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762550003286 TPR motif; other site 762550003287 binding surface 762550003288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 762550003289 TPR motif; other site 762550003290 binding surface 762550003291 CsbD-like; Region: CsbD; cl01272 762550003292 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 762550003293 IHF dimer interface [polypeptide binding]; other site 762550003294 IHF - DNA interface [nucleotide binding]; other site 762550003295 GTP-binding protein Der; Reviewed; Region: PRK00093 762550003296 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 762550003297 G1 box; other site 762550003298 GTP/Mg2+ binding site [chemical binding]; other site 762550003299 Switch I region; other site 762550003300 G2 box; other site 762550003301 Switch II region; other site 762550003302 G3 box; other site 762550003303 G4 box; other site 762550003304 G5 box; other site 762550003305 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 762550003306 G1 box; other site 762550003307 GTP/Mg2+ binding site [chemical binding]; other site 762550003308 Switch I region; other site 762550003309 G2 box; other site 762550003310 G3 box; other site 762550003311 Switch II region; other site 762550003312 G4 box; other site 762550003313 G5 box; other site 762550003314 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 762550003315 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762550003316 RNA binding site [nucleotide binding]; other site 762550003317 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762550003318 RNA binding site [nucleotide binding]; other site 762550003319 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 762550003320 RNA binding site [nucleotide binding]; other site 762550003321 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 762550003322 RNA binding site [nucleotide binding]; other site 762550003323 cytidylate kinase; Provisional; Region: cmk; PRK00023 762550003324 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762550003325 CMP-binding site; other site 762550003326 The sites determining sugar specificity; other site 762550003327 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 762550003328 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550003329 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762550003330 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550003331 RNA binding surface [nucleotide binding]; other site 762550003332 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 762550003333 active site 762550003334 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 762550003335 ScpA/B protein; Region: ScpA_ScpB; cl00598 762550003336 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 762550003337 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 762550003338 Int/Topo IB signature motif; other site 762550003339 active site 762550003340 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 762550003341 GatB domain; Region: GatB_Yqey; cl11497 762550003342 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 762550003343 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 762550003344 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 762550003345 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 762550003346 active site 762550003347 Zn binding site [ion binding]; other site 762550003348 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 762550003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003350 putative substrate translocation pore; other site 762550003351 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 762550003352 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 762550003353 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550003354 Amino acid permease; Region: AA_permease; pfam00324 762550003355 Domain of unknown function (DUF697); Region: DUF697; cl12064 762550003356 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550003357 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 762550003358 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003359 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550003360 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003361 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 762550003362 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762550003363 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762550003364 dimer interface [polypeptide binding]; other site 762550003365 anticodon binding site; other site 762550003366 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 762550003367 homodimer interface [polypeptide binding]; other site 762550003368 motif 1; other site 762550003369 active site 762550003370 motif 2; other site 762550003371 GAD domain; Region: GAD; pfam02938 762550003372 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550003373 active site 762550003374 motif 3; other site 762550003375 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762550003376 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 762550003377 dimer interface [polypeptide binding]; other site 762550003378 motif 1; other site 762550003379 active site 762550003380 motif 2; other site 762550003381 motif 3; other site 762550003382 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762550003383 anticodon binding site; other site 762550003384 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003385 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550003386 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 762550003387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550003388 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003389 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550003390 catabolite control protein A; Region: ccpA; TIGR01481 762550003391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003392 DNA binding site [nucleotide binding] 762550003393 domain linker motif; other site 762550003394 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550003395 dimerization interface [polypeptide binding]; other site 762550003396 ligand binding site [chemical binding]; other site 762550003397 beta-phosphoglucomutase; Region: bPGM; TIGR01990 762550003398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550003399 motif II; other site 762550003400 maltose phosphorylase; Provisional; Region: PRK13807 762550003401 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 762550003402 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 762550003403 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 762550003404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550003405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003407 DNA binding site [nucleotide binding] 762550003408 domain linker motif; other site 762550003409 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550003410 ligand binding site [chemical binding]; other site 762550003411 dimerization interface [polypeptide binding]; other site 762550003412 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003414 DNA binding site [nucleotide binding] 762550003415 domain linker motif; other site 762550003416 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550003417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762550003418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550003419 dimer interface [polypeptide binding]; other site 762550003420 conserved gate region; other site 762550003421 putative PBP binding loops; other site 762550003422 ABC-ATPase subunit interface; other site 762550003423 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 762550003424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550003425 dimer interface [polypeptide binding]; other site 762550003426 conserved gate region; other site 762550003427 putative PBP binding loops; other site 762550003428 ABC-ATPase subunit interface; other site 762550003429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762550003430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550003431 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762550003432 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 762550003433 Walker A/P-loop; other site 762550003434 ATP binding site [chemical binding]; other site 762550003435 Q-loop/lid; other site 762550003436 ABC transporter signature motif; other site 762550003437 Walker B; other site 762550003438 D-loop; other site 762550003439 H-loop/switch region; other site 762550003440 TOBE domain; Region: TOBE_2; cl01440 762550003441 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 762550003442 homodimer; other site 762550003443 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 762550003444 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550003445 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003446 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550003447 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 762550003448 dimer interface [polypeptide binding]; other site 762550003449 FMN binding site [chemical binding]; other site 762550003450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550003451 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 762550003452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550003453 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 762550003454 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 762550003455 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 762550003456 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 762550003457 putative dimer interface [polypeptide binding]; other site 762550003458 putative anticodon binding site; other site 762550003459 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 762550003460 homodimer interface [polypeptide binding]; other site 762550003461 motif 1; other site 762550003462 motif 2; other site 762550003463 active site 762550003464 motif 3; other site 762550003465 hypothetical protein; Provisional; Region: PRK08912 762550003466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550003467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550003468 homodimer interface [polypeptide binding]; other site 762550003469 catalytic residue [active] 762550003470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 762550003471 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 762550003472 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762550003473 active site 762550003474 catalytic site [active] 762550003475 substrate binding site [chemical binding]; other site 762550003476 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 762550003477 mevalonate kinase; Region: mevalon_kin; TIGR00549 762550003478 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 762550003479 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 762550003480 active site 762550003481 catalytic site [active] 762550003482 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 762550003483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 762550003484 active site 762550003485 catalytic tetrad [active] 762550003486 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762550003487 active site 762550003488 catalytic triad [active] 762550003489 oxyanion hole [active] 762550003490 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 762550003491 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550003492 RecD/TraA family; Region: recD_rel; TIGR01448 762550003493 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762550003494 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550003495 catalytic core [active] 762550003496 Domain of unknown function (DUF1831); Region: DUF1831; pfam08866 762550003497 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550003498 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 762550003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550003500 Uncharacterized conserved protein [Function unknown]; Region: COG3270 762550003501 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 762550003502 substrate binding site [chemical binding]; other site 762550003503 dimer interface [polypeptide binding]; other site 762550003504 ATP binding site [chemical binding]; other site 762550003505 Phosphate-starvation-inducible E; Region: PsiE; cl01264 762550003506 DNA polymerase III PolC; Validated; Region: polC; PRK00448 762550003507 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 762550003508 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 762550003509 generic binding surface II; other site 762550003510 generic binding surface I; other site 762550003511 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 762550003512 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762550003513 active site 762550003514 substrate binding site [chemical binding]; other site 762550003515 catalytic site [active] 762550003516 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 762550003517 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762550003518 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 762550003519 dimer interface [polypeptide binding]; other site 762550003520 motif 1; other site 762550003521 active site 762550003522 motif 2; other site 762550003523 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 762550003524 putative deacylase active site [active] 762550003525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550003526 active site 762550003527 motif 3; other site 762550003528 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 762550003529 anticodon binding site; other site 762550003530 RIP metalloprotease RseP; Region: TIGR00054 762550003531 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762550003532 active site 762550003533 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762550003534 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 762550003535 protein binding site [polypeptide binding]; other site 762550003536 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762550003537 putative substrate binding region [chemical binding]; other site 762550003538 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 762550003539 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 762550003540 catalytic residue [active] 762550003541 putative FPP diphosphate binding site; other site 762550003542 putative FPP binding hydrophobic cleft; other site 762550003543 dimer interface [polypeptide binding]; other site 762550003544 putative IPP diphosphate binding site; other site 762550003545 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762550003546 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 762550003547 glutaminase active site [active] 762550003548 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762550003549 dimer interface [polypeptide binding]; other site 762550003550 active site 762550003551 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762550003552 dimer interface [polypeptide binding]; other site 762550003553 active site 762550003554 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 762550003555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762550003556 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 762550003557 active site 762550003558 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 762550003559 DNA translocase FtsK; Provisional; Region: PRK10263 762550003560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550003561 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 762550003562 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762550003563 Domain of unknown function DUF20; Region: UPF0118; cl00465 762550003564 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 762550003565 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 762550003566 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 762550003567 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 762550003568 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550003569 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 762550003570 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 762550003571 homotetramer interface [polypeptide binding]; other site 762550003572 FMN binding site [chemical binding]; other site 762550003573 homodimer contacts [polypeptide binding]; other site 762550003574 putative active site [active] 762550003575 putative substrate binding site [chemical binding]; other site 762550003576 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550003577 adenylosuccinate lyase; Provisional; Region: PRK07492 762550003578 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 762550003579 tetramer interface [polypeptide binding]; other site 762550003580 active site 762550003581 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 762550003582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003583 putative substrate translocation pore; other site 762550003584 Predicted esterase [General function prediction only]; Region: COG0627 762550003585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 762550003586 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 762550003587 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 762550003588 Potassium binding sites [ion binding]; other site 762550003589 Cesium cation binding sites [ion binding]; other site 762550003590 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762550003591 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762550003592 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550003593 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762550003594 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 762550003595 putative active site [active] 762550003596 nucleotide binding site [chemical binding]; other site 762550003597 nudix motif; other site 762550003598 putative metal binding site [ion binding]; other site 762550003599 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762550003600 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 762550003601 purine monophosphate binding site [chemical binding]; other site 762550003602 dimer interface [polypeptide binding]; other site 762550003603 putative catalytic residues [active] 762550003604 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 762550003605 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762550003606 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762550003607 active site 762550003608 substrate binding site [chemical binding]; other site 762550003609 cosubstrate binding site; other site 762550003610 catalytic site [active] 762550003611 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762550003612 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 762550003613 dimerization interface [polypeptide binding]; other site 762550003614 putative ATP binding site [chemical binding]; other site 762550003615 amidophosphoribosyltransferase; Provisional; Region: PRK07272 762550003616 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762550003617 active site 762550003618 tetramer interface [polypeptide binding]; other site 762550003619 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550003620 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 762550003621 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 762550003622 dimerization interface [polypeptide binding]; other site 762550003623 ATP binding site [chemical binding]; other site 762550003624 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 762550003625 dimerization interface [polypeptide binding]; other site 762550003626 ATP binding site [chemical binding]; other site 762550003627 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762550003628 putative active site [active] 762550003629 catalytic triad [active] 762550003630 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 762550003631 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 762550003632 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 762550003633 ATP binding site [chemical binding]; other site 762550003634 active site 762550003635 substrate binding site [chemical binding]; other site 762550003636 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762550003637 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550003638 AIR carboxylase; Region: AIRC; cl00310 762550003639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550003640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550003641 substrate binding pocket [chemical binding]; other site 762550003642 membrane-bound complex binding site; other site 762550003643 hinge residues; other site 762550003644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550003645 dimer interface [polypeptide binding]; other site 762550003646 conserved gate region; other site 762550003647 ABC-ATPase subunit interface; other site 762550003648 cell division protein GpsB; Provisional; Region: PRK14127 762550003649 DivIVA domain; Region: DivI1A_domain; TIGR03544 762550003650 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 762550003651 Transglycosylase; Region: Transgly; cl07896 762550003652 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 762550003653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762550003654 Recombination protein U; Region: RecU; cl01314 762550003655 GMP synthase; Reviewed; Region: guaA; PRK00074 762550003656 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762550003657 AMP/PPi binding site [chemical binding]; other site 762550003658 candidate oxyanion hole; other site 762550003659 catalytic triad [active] 762550003660 potential glutamine specificity residues [chemical binding]; other site 762550003661 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762550003662 ATP Binding subdomain [chemical binding]; other site 762550003663 Dimerization subdomain; other site 762550003664 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762550003665 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 762550003666 phosphate binding site [ion binding]; other site 762550003667 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762550003668 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 762550003669 active site 762550003670 Peptidase family M48; Region: Peptidase_M48; cl12018 762550003671 LemA family; Region: LemA; cl00742 762550003672 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 762550003673 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 762550003674 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762550003675 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762550003676 HIGH motif; other site 762550003677 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762550003678 active site 762550003679 KMSKS motif; other site 762550003680 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762550003681 tRNA binding surface [nucleotide binding]; other site 762550003682 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762550003683 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762550003684 active site 762550003685 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 762550003686 active site 762550003687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550003688 Ligand Binding Site [chemical binding]; other site 762550003689 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550003690 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550003691 active site 762550003692 dimer interface [polypeptide binding]; other site 762550003693 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550003694 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762550003695 Walker A/P-loop; other site 762550003696 ATP binding site [chemical binding]; other site 762550003697 Q-loop/lid; other site 762550003698 ABC transporter signature motif; other site 762550003699 Walker B; other site 762550003700 D-loop; other site 762550003701 H-loop/switch region; other site 762550003702 elongation factor Tu; Reviewed; Region: PRK00049 762550003703 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 762550003704 G1 box; other site 762550003705 GEF interaction site [polypeptide binding]; other site 762550003706 GTP/Mg2+ binding site [chemical binding]; other site 762550003707 Switch I region; other site 762550003708 G2 box; other site 762550003709 G3 box; other site 762550003710 Switch II region; other site 762550003711 G4 box; other site 762550003712 G5 box; other site 762550003713 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762550003714 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 762550003715 Antibiotic Binding Site [chemical binding]; other site 762550003716 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762550003717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550003718 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762550003719 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762550003720 23S rRNA binding site [nucleotide binding]; other site 762550003721 L21 binding site [polypeptide binding]; other site 762550003722 L13 binding site [polypeptide binding]; other site 762550003723 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 762550003724 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762550003725 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762550003726 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 762550003727 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550003728 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762550003729 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 762550003730 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 762550003731 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762550003732 active site 762550003733 dimer interface [polypeptide binding]; other site 762550003734 motif 1; other site 762550003735 motif 2; other site 762550003736 motif 3; other site 762550003737 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762550003738 anticodon binding site; other site 762550003739 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 762550003740 amphipathic channel; other site 762550003741 Asn-Pro-Ala signature motifs; other site 762550003742 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550003743 Domain of unknown function DUF28; Region: DUF28; cl00361 762550003744 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762550003745 tetramer interfaces [polypeptide binding]; other site 762550003746 binuclear metal-binding site [ion binding]; other site 762550003747 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 762550003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550003749 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 762550003750 L-serine binding site [chemical binding]; other site 762550003751 ACT domain interface; other site 762550003752 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762550003753 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762550003754 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550003755 catalytic residue [active] 762550003756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550003757 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550003758 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 762550003759 Walker A/P-loop; other site 762550003760 ATP binding site [chemical binding]; other site 762550003761 Q-loop/lid; other site 762550003762 ABC transporter signature motif; other site 762550003763 Walker B; other site 762550003764 D-loop; other site 762550003765 H-loop/switch region; other site 762550003766 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762550003767 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 762550003768 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 762550003769 Scramblase; Region: Scramblase; cl02043 762550003770 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 762550003771 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 762550003772 FAD binding site [chemical binding]; other site 762550003773 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 762550003774 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 762550003775 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550003776 Amino acid permease; Region: AA_permease; pfam00324 762550003777 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550003778 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550003779 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762550003780 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 762550003781 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550003782 active site 762550003783 HIGH motif; other site 762550003784 nucleotide binding site [chemical binding]; other site 762550003785 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762550003786 active site 762550003787 KMSKS motif; other site 762550003788 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 762550003789 tRNA binding surface [nucleotide binding]; other site 762550003790 anticodon binding site; other site 762550003791 DivIVA domain; Region: DivI1A_domain; TIGR03544 762550003792 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 762550003793 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 762550003794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762550003795 Protein of unknown function (DUF552); Region: DUF552; cl00775 762550003796 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 762550003797 nucleotide binding site [chemical binding]; other site 762550003798 SulA interaction site; other site 762550003799 cell division protein FtsA; Region: ftsA; TIGR01174 762550003800 Cell division protein FtsA; Region: FtsA; cl11496 762550003801 Cell division protein FtsA; Region: FtsA; cl11496 762550003802 Cell division protein FtsQ; Region: FtsQ; pfam03799 762550003803 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762550003804 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 762550003805 active site 762550003806 homodimer interface [polypeptide binding]; other site 762550003807 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 762550003808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550003809 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762550003810 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 762550003811 Mg++ binding site [ion binding]; other site 762550003812 putative catalytic motif [active] 762550003813 putative substrate binding site [chemical binding]; other site 762550003814 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762550003815 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762550003816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762550003817 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 762550003818 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 762550003819 Septum formation initiator; Region: DivIC; cl11433 762550003820 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 762550003821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550003822 cell division protein MraZ; Reviewed; Region: PRK00326 762550003823 MraZ protein; Region: MraZ; pfam02381 762550003824 MraZ protein; Region: MraZ; pfam02381 762550003825 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 762550003826 DAK2 domain; Region: Dak2; cl03685 762550003827 Protein of unknown function (DUF322); Region: DUF322; cl00574 762550003828 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 762550003829 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550003830 catalytic residues [active] 762550003831 Thiamine pyrophosphokinase; Region: TPK; cd07995 762550003832 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 762550003833 active site 762550003834 dimerization interface [polypeptide binding]; other site 762550003835 thiamine binding site [chemical binding]; other site 762550003836 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 762550003837 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 762550003838 substrate binding site [chemical binding]; other site 762550003839 hexamer interface [polypeptide binding]; other site 762550003840 metal binding site [ion binding]; metal-binding site 762550003841 GTPase RsgA; Reviewed; Region: PRK00098 762550003842 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 762550003843 GTPase/OB domain interface [polypeptide binding]; other site 762550003844 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762550003845 GTP/Mg2+ binding site [chemical binding]; other site 762550003846 G4 box; other site 762550003847 G5 box; other site 762550003848 G1 box; other site 762550003849 Switch I region; other site 762550003850 G2 box; other site 762550003851 G3 box; other site 762550003852 Switch II region; other site 762550003853 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762550003854 active site 762550003855 ATP binding site [chemical binding]; other site 762550003856 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762550003857 substrate binding site [chemical binding]; other site 762550003858 activation loop (A-loop); other site 762550003859 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 762550003860 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 762550003861 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 762550003862 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 762550003863 Active site [active] 762550003864 16S rRNA methyltransferase B; Provisional; Region: PRK14902 762550003865 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 762550003866 putative RNA binding site [nucleotide binding]; other site 762550003867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550003868 S-adenosylmethionine binding site [chemical binding]; other site 762550003869 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762550003870 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762550003871 putative active site [active] 762550003872 substrate binding site [chemical binding]; other site 762550003873 putative cosubstrate binding site; other site 762550003874 catalytic site [active] 762550003875 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762550003876 substrate binding site [chemical binding]; other site 762550003877 primosome assembly protein PriA; Validated; Region: PRK05580 762550003878 primosome assembly protein PriA; Validated; Region: PRK05580 762550003879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550003880 ATP binding site [chemical binding]; other site 762550003881 putative Mg++ binding site [ion binding]; other site 762550003882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 762550003883 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 762550003884 G1 box; other site 762550003885 GTP/Mg2+ binding site [chemical binding]; other site 762550003886 Switch I region; other site 762550003887 G2 box; other site 762550003888 G3 box; other site 762550003889 Switch II region; other site 762550003890 G4 box; other site 762550003891 G5 box; other site 762550003892 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762550003893 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762550003894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550003895 Walker A motif; other site 762550003896 ATP binding site [chemical binding]; other site 762550003897 Walker B motif; other site 762550003898 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550003899 trigger factor; Provisional; Region: tig; PRK01490 762550003900 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 762550003901 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762550003902 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550003903 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550003904 NlpC/P60 family; Region: NLPC_P60; cl11438 762550003905 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 762550003906 acetoin reductases; Region: 23BDH; TIGR02415 762550003907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550003908 NAD(P) binding site [chemical binding]; other site 762550003909 active site 762550003910 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 762550003911 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550003912 active site 762550003913 nucleotide binding site [chemical binding]; other site 762550003914 HIGH motif; other site 762550003915 KMSKS motif; other site 762550003916 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 762550003917 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762550003918 SelR domain; Region: SelR; cl00369 762550003919 dipeptidase PepV; Reviewed; Region: PRK07318 762550003920 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762550003921 active site 762550003922 metal binding site [ion binding]; metal-binding site 762550003923 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762550003924 putative substrate binding site [chemical binding]; other site 762550003925 putative ATP binding site [chemical binding]; other site 762550003926 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 762550003927 active site 762550003928 DNA binding site [nucleotide binding] 762550003929 putative phosphate binding site [ion binding]; other site 762550003930 putative catalytic site [active] 762550003931 metal binding site A [ion binding]; metal-binding site 762550003932 AP binding site [nucleotide binding]; other site 762550003933 metal binding site B [ion binding]; metal-binding site 762550003934 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 762550003935 active site 762550003936 substrate binding site [chemical binding]; other site 762550003937 catalytic site [active] 762550003938 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762550003939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550003940 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 762550003941 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 762550003942 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 762550003943 active site 762550003944 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 762550003945 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 762550003946 homodimer interface [polypeptide binding]; other site 762550003947 NAD binding pocket [chemical binding]; other site 762550003948 ATP binding pocket [chemical binding]; other site 762550003949 Mg binding site [ion binding]; other site 762550003950 active-site loop [active] 762550003951 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 762550003952 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 762550003953 protein binding site [polypeptide binding]; other site 762550003954 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762550003955 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762550003956 active site 762550003957 (T/H)XGH motif; other site 762550003958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550003959 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 762550003960 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 762550003961 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 762550003962 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 762550003963 oligomer interface [polypeptide binding]; other site 762550003964 active site 762550003965 metal binding site [ion binding]; metal-binding site 762550003966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550003967 catalytic core [active] 762550003968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550003969 Sulfate transporter family; Region: Sulfate_transp; cl00967 762550003970 Permease family; Region: Xan_ur_permease; pfam00860 762550003971 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762550003972 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 762550003973 Walker A/P-loop; other site 762550003974 ATP binding site [chemical binding]; other site 762550003975 Q-loop/lid; other site 762550003976 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 762550003977 ABC transporter signature motif; other site 762550003978 Walker B; other site 762550003979 D-loop; other site 762550003980 H-loop/switch region; other site 762550003981 Arginine repressor [Transcription]; Region: ArgR; COG1438 762550003982 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762550003983 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762550003984 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 762550003985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 762550003986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550003987 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762550003988 substrate binding pocket [chemical binding]; other site 762550003989 chain length determination region; other site 762550003990 aspartate-rich region 1; other site 762550003991 substrate-Mg2+ binding site; other site 762550003992 catalytic residues [active] 762550003993 active site lid residues [active] 762550003994 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 762550003995 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762550003996 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 762550003997 generic binding surface II; other site 762550003998 generic binding surface I; other site 762550003999 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 762550004000 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762550004001 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762550004002 nucleotide binding pocket [chemical binding]; other site 762550004003 K-X-D-G motif; other site 762550004004 catalytic site [active] 762550004005 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762550004006 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762550004007 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 762550004008 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 762550004009 Dimer interface [polypeptide binding]; other site 762550004010 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 762550004011 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762550004012 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 762550004013 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 762550004014 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 762550004015 Walker A/P-loop; other site 762550004016 ATP binding site [chemical binding]; other site 762550004017 Q-loop/lid; other site 762550004018 ABC transporter signature motif; other site 762550004019 Walker B; other site 762550004020 D-loop; other site 762550004021 H-loop/switch region; other site 762550004022 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 762550004023 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550004024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550004025 Walker A/P-loop; other site 762550004026 ATP binding site [chemical binding]; other site 762550004027 Q-loop/lid; other site 762550004028 ABC transporter signature motif; other site 762550004029 Walker B; other site 762550004030 D-loop; other site 762550004031 H-loop/switch region; other site 762550004032 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762550004033 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762550004034 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 762550004035 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 762550004036 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 762550004037 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 762550004038 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762550004039 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 762550004040 motif 1; other site 762550004041 active site 762550004042 motif 2; other site 762550004043 motif 3; other site 762550004044 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 762550004045 DHHA1 domain; Region: DHHA1; pfam02272 762550004046 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 762550004047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762550004048 inhibitor-cofactor binding pocket; inhibition site 762550004049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550004050 catalytic residue [active] 762550004051 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 762550004052 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550004053 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550004054 gluconate transporter; Region: gntP; TIGR00791 762550004055 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 762550004056 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550004057 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 762550004058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004059 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 762550004060 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762550004061 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 762550004062 putative active site [active] 762550004063 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 762550004064 Sugar specificity; other site 762550004065 Pyrimidine base specificity; other site 762550004066 ATP-binding site [chemical binding]; other site 762550004067 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 762550004068 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 762550004069 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 762550004070 catalytic triad [active] 762550004071 catalytic triad [active] 762550004072 oxyanion hole [active] 762550004073 catabolite control protein A; Region: ccpA; TIGR01481 762550004074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004075 DNA binding site [nucleotide binding] 762550004076 domain linker motif; other site 762550004077 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 762550004078 dimerization interface [polypeptide binding]; other site 762550004079 effector binding site; other site 762550004080 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762550004081 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762550004082 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762550004083 active site 762550004084 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 762550004085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550004086 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550004087 active site 762550004088 motif I; other site 762550004089 motif II; other site 762550004090 hypothetical protein; Provisional; Region: PRK04351 762550004091 SprT homologues; Region: SprT; cl01182 762550004092 GAF domain; Region: GAF; cl00853 762550004093 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762550004094 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 762550004095 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550004096 Amino acid permease; Region: AA_permease; pfam00324 762550004097 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 762550004098 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 762550004099 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 762550004100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004101 Zn2+ binding site [ion binding]; other site 762550004102 Mg2+ binding site [ion binding]; other site 762550004103 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 762550004104 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 762550004105 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 762550004106 benzoate transport; Region: 2A0115; TIGR00895 762550004107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004108 putative substrate translocation pore; other site 762550004109 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 762550004110 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 762550004111 Zn binding site [ion binding]; other site 762550004112 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550004113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004114 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762550004115 substrate binding site [chemical binding]; other site 762550004116 ATP binding site [chemical binding]; other site 762550004117 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762550004118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004120 DNA binding site [nucleotide binding] 762550004121 domain linker motif; other site 762550004122 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 762550004123 putative dimerization interface [polypeptide binding]; other site 762550004124 putative ligand binding site [chemical binding]; other site 762550004125 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762550004126 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762550004127 IPP transferase; Region: IPPT; cl00403 762550004128 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550004129 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762550004130 active site 762550004131 catalytic site [active] 762550004132 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 762550004133 peroxiredoxin; Region: AhpC; TIGR03137 762550004134 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 762550004135 dimer interface [polypeptide binding]; other site 762550004136 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762550004137 catalytic triad [active] 762550004138 peroxidatic and resolving cysteines [active] 762550004139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004140 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 762550004141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004142 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 762550004143 catalytic residue [active] 762550004144 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762550004145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550004146 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762550004147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004149 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550004150 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762550004151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762550004152 E3 interaction surface; other site 762550004153 lipoyl attachment site [posttranslational modification]; other site 762550004154 e3 binding domain; Region: E3_binding; pfam02817 762550004155 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 762550004156 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762550004157 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762550004158 alpha subunit interface [polypeptide binding]; other site 762550004159 TPP binding site [chemical binding]; other site 762550004160 heterodimer interface [polypeptide binding]; other site 762550004161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762550004162 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 762550004163 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762550004164 tetramer interface [polypeptide binding]; other site 762550004165 TPP-binding site [chemical binding]; other site 762550004166 heterodimer interface [polypeptide binding]; other site 762550004167 phosphorylation loop region [posttranslational modification] 762550004168 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 762550004169 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762550004170 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 762550004171 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762550004172 active site residue [active] 762550004173 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 762550004174 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 762550004175 putative catalytic residues [active] 762550004176 thiol/disulfide switch; other site 762550004177 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 762550004178 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 762550004179 RNA binding site [nucleotide binding]; other site 762550004180 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 762550004181 active site 762550004182 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 762550004183 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 762550004184 catalytic site [active] 762550004185 G-X2-G-X-G-K; other site 762550004186 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 762550004187 phosphodiesterase; Provisional; Region: PRK12704 762550004188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004189 Zn2+ binding site [ion binding]; other site 762550004190 Mg2+ binding site [ion binding]; other site 762550004191 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762550004192 SmpB-tmRNA interface; other site 762550004193 ribonuclease R; Region: RNase_R; TIGR02063 762550004194 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 762550004195 RNB domain; Region: RNB; pfam00773 762550004196 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 762550004197 RNA binding site [nucleotide binding]; other site 762550004198 Preprotein translocase SecG subunit; Region: SecG; cl09123 762550004199 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762550004200 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762550004201 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762550004202 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 762550004203 Acylphosphatase; Region: Acylphosphatase; cl00551 762550004204 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 762550004205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762550004206 dimer interface [polypeptide binding]; other site 762550004207 phosphorylation site [posttranslational modification] 762550004208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550004209 ATP binding site [chemical binding]; other site 762550004210 Mg2+ binding site [ion binding]; other site 762550004211 G-X-G motif; other site 762550004212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550004213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550004214 active site 762550004215 phosphorylation site [posttranslational modification] 762550004216 intermolecular recognition site; other site 762550004217 dimerization interface [polypeptide binding]; other site 762550004218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550004219 DNA binding site [nucleotide binding] 762550004220 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 762550004221 hypothetical protein; Provisional; Region: PRK13670 762550004222 hypothetical protein; Provisional; Region: PRK13671 762550004223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550004224 Domain of unknown function DUF143; Region: DUF143; cl00519 762550004225 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 762550004226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004227 Zn2+ binding site [ion binding]; other site 762550004228 Mg2+ binding site [ion binding]; other site 762550004229 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 762550004230 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762550004231 active site 762550004232 (T/H)XGH motif; other site 762550004233 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 762550004234 GTPase YqeH; Provisional; Region: PRK13796 762550004235 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 762550004236 GTP/Mg2+ binding site [chemical binding]; other site 762550004237 G4 box; other site 762550004238 G5 box; other site 762550004239 G1 box; other site 762550004240 Switch I region; other site 762550004241 G2 box; other site 762550004242 G3 box; other site 762550004243 Switch II region; other site 762550004244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550004245 active site 762550004246 motif I; other site 762550004247 motif II; other site 762550004248 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550004249 D-lactate dehydrogenase; Validated; Region: PRK08605 762550004250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004251 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762550004252 oligomer interface [polypeptide binding]; other site 762550004253 active site residues [active] 762550004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 762550004255 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 762550004256 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 762550004257 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 762550004258 phosphate binding site [ion binding]; other site 762550004259 putative substrate binding pocket [chemical binding]; other site 762550004260 dimer interface [polypeptide binding]; other site 762550004261 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762550004262 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762550004263 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 762550004264 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 762550004265 excinuclease ABC subunit B; Provisional; Region: PRK05298 762550004266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550004267 ATP binding site [chemical binding]; other site 762550004268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004269 nucleotide binding region [chemical binding]; other site 762550004270 ATP-binding site [chemical binding]; other site 762550004271 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762550004272 UvrB/uvrC motif; Region: UVR; pfam02151 762550004273 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762550004274 Sulfatase; Region: Sulfatase; cl10460 762550004275 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 762550004276 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 762550004277 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762550004278 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550004279 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 762550004280 putative ADP-binding pocket [chemical binding]; other site 762550004281 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550004282 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550004283 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 762550004284 Walker A/P-loop; other site 762550004285 ATP binding site [chemical binding]; other site 762550004286 Q-loop/lid; other site 762550004287 ABC transporter signature motif; other site 762550004288 Walker B; other site 762550004289 D-loop; other site 762550004290 H-loop/switch region; other site 762550004291 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 762550004292 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550004293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550004294 Walker A/P-loop; other site 762550004295 ATP binding site [chemical binding]; other site 762550004296 Q-loop/lid; other site 762550004297 ABC transporter signature motif; other site 762550004298 Walker B; other site 762550004299 D-loop; other site 762550004300 H-loop/switch region; other site 762550004301 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 762550004302 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550004303 Walker A/P-loop; other site 762550004304 ATP binding site [chemical binding]; other site 762550004305 Q-loop/lid; other site 762550004306 ABC transporter signature motif; other site 762550004307 Walker B; other site 762550004308 D-loop; other site 762550004309 H-loop/switch region; other site 762550004310 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762550004311 FtsX-like permease family; Region: FtsX; pfam02687 762550004312 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 762550004313 nudix motif; other site 762550004314 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550004315 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 762550004316 Uncharacterized conserved protein [Function unknown]; Region: COG2898 762550004317 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 762550004318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550004319 Preprotein translocase subunit; Region: YajC; cl00806 762550004320 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 762550004321 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762550004322 MPN+ (JAMM) motif; other site 762550004323 Zinc-binding site [ion binding]; other site 762550004324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550004326 putative substrate translocation pore; other site 762550004327 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 762550004328 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550004329 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 762550004330 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 762550004331 ATP binding site [chemical binding]; other site 762550004332 Mg++ binding site [ion binding]; other site 762550004333 motif III; other site 762550004334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004335 nucleotide binding region [chemical binding]; other site 762550004336 ATP-binding site [chemical binding]; other site 762550004337 Beta-lactamase; Region: Beta-lactamase; cl01009 762550004338 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762550004339 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 762550004340 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550004341 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550004342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550004343 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 762550004344 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 762550004345 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762550004346 hinge; other site 762550004347 active site 762550004348 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762550004349 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762550004350 putative tRNA-binding site [nucleotide binding]; other site 762550004351 B3/4 domain; Region: B3_4; cl11458 762550004352 tRNA synthetase B5 domain; Region: B5; cl08394 762550004353 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762550004354 dimer interface [polypeptide binding]; other site 762550004355 motif 1; other site 762550004356 motif 3; other site 762550004357 motif 2; other site 762550004358 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762550004359 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762550004360 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762550004361 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762550004362 dimer interface [polypeptide binding]; other site 762550004363 motif 1; other site 762550004364 active site 762550004365 motif 2; other site 762550004366 motif 3; other site 762550004367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550004368 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762550004369 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550004370 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 762550004371 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762550004372 active site 762550004373 metal binding site [ion binding]; metal-binding site 762550004374 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 762550004375 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762550004376 putative NAD(P) binding site [chemical binding]; other site 762550004377 catalytic Zn binding site [ion binding]; other site 762550004378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004380 DNA binding site [nucleotide binding] 762550004381 domain linker motif; other site 762550004382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550004383 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550004384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004385 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 762550004386 active site 762550004387 catalytic motif [active] 762550004388 Zn binding site [ion binding]; other site 762550004389 oligoendopeptidase F; Region: pepF; TIGR00181 762550004390 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 762550004391 active site 762550004392 Zn binding site [ion binding]; other site 762550004393 Competence protein CoiA-like family; Region: CoiA; cl11541 762550004394 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550004395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550004396 substrate binding pocket [chemical binding]; other site 762550004397 membrane-bound complex binding site; other site 762550004398 hinge residues; other site 762550004399 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550004400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550004401 dimer interface [polypeptide binding]; other site 762550004402 conserved gate region; other site 762550004403 putative PBP binding loops; other site 762550004404 ABC-ATPase subunit interface; other site 762550004405 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550004406 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 762550004407 Walker A/P-loop; other site 762550004408 ATP binding site [chemical binding]; other site 762550004409 Q-loop/lid; other site 762550004410 ABC transporter signature motif; other site 762550004411 Walker B; other site 762550004412 D-loop; other site 762550004413 H-loop/switch region; other site 762550004414 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550004415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 762550004416 substrate binding pocket [chemical binding]; other site 762550004417 membrane-bound complex binding site; other site 762550004418 hinge residues; other site 762550004419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550004420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550004421 dimer interface [polypeptide binding]; other site 762550004422 conserved gate region; other site 762550004423 putative PBP binding loops; other site 762550004424 ABC-ATPase subunit interface; other site 762550004425 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 762550004426 ligand binding site [chemical binding]; other site 762550004427 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 762550004428 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 762550004429 YibE/F-like protein; Region: YibE_F; cl02259 762550004430 YibE/F-like protein; Region: YibE_F; cl02259 762550004431 primosomal protein DnaI; Reviewed; Region: PRK08939 762550004432 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 762550004433 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 762550004434 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762550004435 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762550004436 CoA-binding site [chemical binding]; other site 762550004437 Protein of unknown function (DUF975); Region: DUF975; cl10504 762550004438 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762550004439 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762550004440 DNA binding site [nucleotide binding] 762550004441 catalytic residue [active] 762550004442 H2TH interface [polypeptide binding]; other site 762550004443 putative catalytic residues [active] 762550004444 turnover-facilitating residue; other site 762550004445 intercalation triad [nucleotide binding]; other site 762550004446 8OG recognition residue [nucleotide binding]; other site 762550004447 putative reading head residues; other site 762550004448 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762550004449 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762550004450 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 762550004451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550004452 Walker A/P-loop; other site 762550004453 ATP binding site [chemical binding]; other site 762550004454 Q-loop/lid; other site 762550004455 ABC transporter signature motif; other site 762550004456 Walker B; other site 762550004457 D-loop; other site 762550004458 H-loop/switch region; other site 762550004459 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 762550004460 Smr domain; Region: Smr; cl02619 762550004461 Colicin V production protein; Region: Colicin_V; cl00567 762550004462 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 762550004463 Phage capsid family; Region: Phage_capsid; pfam05065 762550004464 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 762550004465 Phage-related protein [Function unknown]; Region: COG4695; cl01923 762550004466 potential frameshift: common BLAST hit: gi|15672451|ref|NP_266625.1| terminase large subunit 762550004467 Phage Terminase; Region: Terminase_1; pfam03354 762550004468 potential frameshift: common BLAST hit: gi|15672451|ref|NP_266625.1| terminase large subunit 762550004469 Phage Terminase; Region: Terminase_1; pfam03354 762550004470 Phage Terminase; Region: Terminase_1; pfam03354 762550004471 Phage terminase, small subunit; Region: Terminase_4; cl01525 762550004472 putative transposase OrfB; Reviewed; Region: PHA02517 762550004473 Integrase core domain; Region: rve; cl01316 762550004474 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550004475 ribonuclease HIII; Provisional; Region: PRK00996 762550004476 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 762550004477 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 762550004478 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550004479 active site 762550004480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550004482 Coenzyme A binding pocket [chemical binding]; other site 762550004483 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 762550004484 DsrE/DsrF-like family; Region: DrsE; cl00672 762550004485 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 762550004486 Virulence-associated protein E; Region: VirE; pfam05272 762550004487 potential frameshift: common BLAST hit: gi|296110912|ref|YP_003621293.1| prophage Lp4 protein 7, DNA replication 762550004488 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 762550004489 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 762550004490 polymerase nucleotide-binding site; other site 762550004491 DNA-binding residues [nucleotide binding]; DNA binding site 762550004492 nucleotide binding site [chemical binding]; other site 762550004493 primase nucleotide-binding site [nucleotide binding]; other site 762550004494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550004495 sequence-specific DNA binding site [nucleotide binding]; other site 762550004496 salt bridge; other site 762550004497 Fic/DOC family; Region: Fic; cl00960 762550004498 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762550004499 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762550004500 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 762550004501 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762550004502 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550004503 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 762550004504 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 762550004505 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762550004506 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762550004507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 762550004508 carboxyltransferase (CT) interaction site; other site 762550004509 biotinylation site [posttranslational modification]; other site 762550004510 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762550004511 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762550004512 dimer interface [polypeptide binding]; other site 762550004513 active site 762550004514 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762550004515 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762550004516 NAD(P) binding site [chemical binding]; other site 762550004517 homotetramer interface [polypeptide binding]; other site 762550004518 homodimer interface [polypeptide binding]; other site 762550004519 active site 762550004520 Acyl transferase domain; Region: Acyl_transf_1; cl08282 762550004521 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762550004522 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 762550004523 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 762550004524 FMN binding site [chemical binding]; other site 762550004525 substrate binding site [chemical binding]; other site 762550004526 putative catalytic residue [active] 762550004527 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762550004528 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762550004529 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762550004530 dimer interface [polypeptide binding]; other site 762550004531 active site 762550004532 CoA binding pocket [chemical binding]; other site 762550004533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550004534 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762550004535 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 762550004536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004537 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 762550004538 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762550004539 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 762550004540 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762550004541 active site 762550004542 HIGH motif; other site 762550004543 KMSKS motif; other site 762550004544 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762550004545 tRNA binding surface [nucleotide binding]; other site 762550004546 anticodon binding site; other site 762550004547 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762550004548 dimer interface [polypeptide binding]; other site 762550004549 putative tRNA-binding site [nucleotide binding]; other site 762550004550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 762550004551 streptodornase; Region: PHA01790 762550004552 Predicted membrane protein [Function unknown]; Region: COG4640 762550004553 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 762550004554 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 762550004555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004556 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650 762550004557 active site 762550004558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004559 catalytic core [active] 762550004560 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 762550004561 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 762550004562 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004564 DNA binding site [nucleotide binding] 762550004565 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550004566 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 762550004567 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 762550004568 putative catalytic cysteine [active] 762550004569 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 762550004570 nucleotide binding site [chemical binding]; other site 762550004571 homotetrameric interface [polypeptide binding]; other site 762550004572 putative phosphate binding site [ion binding]; other site 762550004573 putative allosteric binding site; other site 762550004574 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762550004575 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 762550004576 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 762550004577 active site 762550004578 Zn binding site [ion binding]; other site 762550004579 Domain of unknown function (DUF368); Region: DUF368; cl00893 762550004580 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 762550004581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550004582 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 762550004583 thiamine phosphate binding site [chemical binding]; other site 762550004584 active site 762550004585 pyrophosphate binding site [ion binding]; other site 762550004586 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 762550004587 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550004588 dimer interface [polypeptide binding]; other site 762550004589 substrate binding site [chemical binding]; other site 762550004590 ATP binding site [chemical binding]; other site 762550004591 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 762550004592 substrate binding site [chemical binding]; other site 762550004593 multimerization interface [polypeptide binding]; other site 762550004594 ATP binding site [chemical binding]; other site 762550004595 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762550004596 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 762550004597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550004598 Walker A motif; other site 762550004599 ATP binding site [chemical binding]; other site 762550004600 Walker B motif; other site 762550004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004602 NmrA-like family; Region: NmrA; pfam05368 762550004603 NAD(P) binding site [chemical binding]; other site 762550004604 active site 762550004605 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762550004606 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762550004607 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 762550004608 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762550004609 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762550004610 domain; Region: GreA_GreB_N; pfam03449 762550004611 C-term; Region: GreA_GreB; pfam01272 762550004612 Sugar transport protein; Region: Sugar_transport; pfam06800 762550004613 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 762550004614 dimerization interface [polypeptide binding]; other site 762550004615 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 762550004616 Acetokinase family; Region: Acetate_kinase; cl01029 762550004617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 762550004618 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 762550004619 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762550004620 amidase catalytic site [active] 762550004621 Zn binding residues [ion binding]; other site 762550004622 substrate binding site [chemical binding]; other site 762550004623 Phage holin; Region: Phage_holin_5; pfam06946 762550004624 Homeobox associated leucine zipper; Region: HALZ; cl02577 762550004625 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 762550004626 gp58-like protein; Region: Gp58; pfam07902 762550004627 Phage tail protein; Region: Sipho_tail; cl11462 762550004628 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 762550004629 Phage-related protein [Function unknown]; Region: COG5412 762550004630 membrane protein P6; Region: PHA01399 762550004631 Phage protein; Region: DUF3647; cl10335 762550004632 Phage major tail protein 2; Region: Phage_tail_2; cl11463 762550004633 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 762550004634 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 762550004635 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 762550004636 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 762550004637 Phage terminase large subunit; Region: Terminase_3; cl12054 762550004638 Terminase-like family; Region: Terminase_6; pfam03237 762550004639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 762550004640 Terminase small subunit; Region: Terminase_2; cl01513 762550004641 Protein of unknown function (DUF722); Region: DUF722; pfam05263 762550004642 Endodeoxyribonuclease RusA; Region: RusA; cl01885 762550004643 Protein of unknown function (DUF968); Region: DUF968; pfam06147 762550004644 ERF superfamily; Region: ERF; pfam04404 762550004645 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 762550004646 AntA/AntB antirepressor; Region: AntA; cl01430 762550004647 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 762550004648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550004649 non-specific DNA binding site [nucleotide binding]; other site 762550004650 salt bridge; other site 762550004651 sequence-specific DNA binding site [nucleotide binding]; other site 762550004652 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 762550004653 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 762550004654 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 762550004655 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 762550004656 catalytic residues [active] 762550004657 catalytic nucleophile [active] 762550004658 Recombinase; Region: Recombinase; pfam07508 762550004659 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 762550004660 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762550004661 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 762550004662 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 762550004663 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550004664 Walker A motif; other site 762550004665 ATP binding site [chemical binding]; other site 762550004666 Walker B motif; other site 762550004667 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 762550004668 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762550004669 active site 762550004670 dimer interface [polypeptide binding]; other site 762550004671 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762550004672 dimer interface [polypeptide binding]; other site 762550004673 active site 762550004674 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 762550004675 active site 762550004676 trimer interface [polypeptide binding]; other site 762550004677 allosteric site; other site 762550004678 active site lid [active] 762550004679 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762550004680 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762550004681 Beta-lactamase; Region: Beta-lactamase; cl01009 762550004682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550004683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 762550004684 dimer interface [polypeptide binding]; other site 762550004685 phosphorylation site [posttranslational modification] 762550004686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550004687 ATP binding site [chemical binding]; other site 762550004688 Mg2+ binding site [ion binding]; other site 762550004689 G-X-G motif; other site 762550004690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550004691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 762550004692 active site 762550004693 phosphorylation site [posttranslational modification] 762550004694 intermolecular recognition site; other site 762550004695 dimerization interface [polypeptide binding]; other site 762550004696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 762550004697 DNA binding site [nucleotide binding] 762550004698 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 762550004699 GTP-binding protein YchF; Reviewed; Region: PRK09601 762550004700 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 762550004701 G1 box; other site 762550004702 GTP/Mg2+ binding site [chemical binding]; other site 762550004703 Switch I region; other site 762550004704 G2 box; other site 762550004705 Switch II region; other site 762550004706 G3 box; other site 762550004707 G4 box; other site 762550004708 G5 box; other site 762550004709 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762550004710 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 762550004711 ParB-like partition proteins; Region: parB_part; TIGR00180 762550004712 ParB-like nuclease domain; Region: ParBc; cl02129 762550004713 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762550004714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762550004715 P-loop; other site 762550004716 Magnesium ion binding site [ion binding]; other site 762550004717 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 762550004718 Magnesium ion binding site [ion binding]; other site 762550004719 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 762550004720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550004721 S-adenosylmethionine binding site [chemical binding]; other site 762550004722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550004723 dimerization interface [polypeptide binding]; other site 762550004724 putative DNA binding site [nucleotide binding]; other site 762550004725 putative Zn2+ binding site [ion binding]; other site 762550004726 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550004727 Ligand Binding Site [chemical binding]; other site 762550004728 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 762550004729 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 762550004730 Cation efflux family; Region: Cation_efflux; cl00316 762550004731 NAD-dependent deacetylase; Provisional; Region: PRK05333 762550004732 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 762550004733 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 762550004734 nucleophile elbow; other site 762550004735 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 762550004736 homodimer interface [polypeptide binding]; other site 762550004737 NAD binding site [chemical binding]; other site 762550004738 catalytic residues [active] 762550004739 substrate binding pocket [chemical binding]; other site 762550004740 flexible flap; other site 762550004741 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762550004742 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550004743 Protein of unknown function (DUF454); Region: DUF454; cl01063 762550004744 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 762550004745 active site 762550004746 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550004747 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762550004748 FemAB family; Region: FemAB; cl11444 762550004749 NlpC/P60 family; Region: NLPC_P60; cl11438 762550004750 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550004751 putative peptidoglycan binding site; other site 762550004752 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 762550004753 putative peptidoglycan binding site; other site 762550004754 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762550004755 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762550004756 dimer interface [polypeptide binding]; other site 762550004757 active site 762550004758 CoA binding pocket [chemical binding]; other site 762550004759 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762550004760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550004761 active site 762550004762 HIGH motif; other site 762550004763 nucleotide binding site [chemical binding]; other site 762550004764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762550004765 active site 762550004766 KMSKS motif; other site 762550004767 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762550004768 tRNA binding surface [nucleotide binding]; other site 762550004769 anticodon binding site; other site 762550004770 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762550004771 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 762550004772 PemK-like protein; Region: PemK; cl00995 762550004773 alanine racemase; Reviewed; Region: alr; PRK00053 762550004774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762550004775 active site 762550004776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550004777 dimer interface [polypeptide binding]; other site 762550004778 substrate binding site [chemical binding]; other site 762550004779 catalytic residues [active] 762550004780 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 762550004781 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550004782 aspartate aminotransferase; Provisional; Region: PRK08361 762550004783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550004784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550004785 homodimer interface [polypeptide binding]; other site 762550004786 catalytic residue [active] 762550004787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550004788 Active site [active] 762550004789 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550004790 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 762550004791 30S subunit binding site; other site 762550004792 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550004793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550004794 ATP binding site [chemical binding]; other site 762550004795 putative Mg++ binding site [ion binding]; other site 762550004796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004797 nucleotide binding region [chemical binding]; other site 762550004798 ATP-binding site [chemical binding]; other site 762550004799 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762550004800 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762550004801 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762550004802 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762550004803 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550004804 polyphosphate kinase; Provisional; Region: PRK05443 762550004805 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 762550004806 putative domain interface [polypeptide binding]; other site 762550004807 putative active site [active] 762550004808 catalytic site [active] 762550004809 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762550004810 putative domain interface [polypeptide binding]; other site 762550004811 putative active site [active] 762550004812 catalytic site [active] 762550004813 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550004814 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 762550004815 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 762550004816 enolase; Provisional; Region: eno; PRK00077 762550004817 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762550004818 dimer interface [polypeptide binding]; other site 762550004819 metal binding site [ion binding]; metal-binding site 762550004820 substrate binding pocket [chemical binding]; other site 762550004821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550004822 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 762550004823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762550004824 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 762550004825 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258 762550004826 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 762550004827 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762550004828 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 762550004829 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762550004830 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762550004831 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762550004832 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762550004833 DNA binding site [nucleotide binding] 762550004834 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762550004835 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 762550004836 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 762550004837 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 762550004838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762550004839 RPB1 interaction site [polypeptide binding]; other site 762550004840 RPB10 interaction site [polypeptide binding]; other site 762550004841 RPB11 interaction site [polypeptide binding]; other site 762550004842 RPB3 interaction site [polypeptide binding]; other site 762550004843 RPB12 interaction site [polypeptide binding]; other site 762550004844 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762550004845 substrate binding site [chemical binding]; other site 762550004846 dimer interface [polypeptide binding]; other site 762550004847 catalytic triad [active] 762550004848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 762550004849 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 762550004850 DNA-binding site [nucleotide binding]; DNA binding site 762550004851 RNA-binding motif; other site 762550004852 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004853 catalytic core [active] 762550004854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004855 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762550004856 active site 762550004857 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 762550004858 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762550004859 dimer interface [polypeptide binding]; other site 762550004860 putative radical transfer pathway; other site 762550004861 diiron center [ion binding]; other site 762550004862 tyrosyl radical; other site 762550004863 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550004864 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 762550004865 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 762550004866 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762550004867 active site 762550004868 dimer interface [polypeptide binding]; other site 762550004869 catalytic residues [active] 762550004870 effector binding site; other site 762550004871 R2 peptide binding site; other site 762550004872 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 762550004873 catalytic residues [active] 762550004874 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762550004875 Domain of unknown function DUF21; Region: DUF21; pfam01595 762550004876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762550004877 Transporter associated domain; Region: CorC_HlyC; pfam03471 762550004878 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004879 catalytic core [active] 762550004880 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 762550004881 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762550004882 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 762550004883 G1 box; other site 762550004884 GTP/Mg2+ binding site [chemical binding]; other site 762550004885 Switch I region; other site 762550004886 G2 box; other site 762550004887 G3 box; other site 762550004888 Switch II region; other site 762550004889 G4 box; other site 762550004890 G5 box; other site 762550004891 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762550004892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550004894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004895 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 762550004896 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762550004897 23S rRNA interface [nucleotide binding]; other site 762550004898 L3 interface [polypeptide binding]; other site 762550004899 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762550004900 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 762550004901 dimerization interface 3.5A [polypeptide binding]; other site 762550004902 active site 762550004903 Cobalt transport protein; Region: CbiQ; cl00463 762550004904 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 762550004905 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550004906 Walker A/P-loop; other site 762550004907 ATP binding site [chemical binding]; other site 762550004908 Q-loop/lid; other site 762550004909 ABC transporter signature motif; other site 762550004910 Walker B; other site 762550004911 D-loop; other site 762550004912 H-loop/switch region; other site 762550004913 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 762550004914 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 762550004915 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 762550004916 Walker A/P-loop; other site 762550004917 ATP binding site [chemical binding]; other site 762550004918 Q-loop/lid; other site 762550004919 ABC transporter signature motif; other site 762550004920 Walker B; other site 762550004921 D-loop; other site 762550004922 H-loop/switch region; other site 762550004923 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 762550004924 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762550004925 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550004926 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762550004927 substrate binding pocket [chemical binding]; other site 762550004928 chain length determination region; other site 762550004929 substrate-Mg2+ binding site; other site 762550004930 catalytic residues [active] 762550004931 aspartate-rich region 1; other site 762550004932 active site lid residues [active] 762550004933 aspartate-rich region 2; other site 762550004934 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 762550004935 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762550004936 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762550004937 alphaNTD - beta interaction site [polypeptide binding]; other site 762550004938 alphaNTD homodimer interface [polypeptide binding]; other site 762550004939 alphaNTD - beta' interaction site [polypeptide binding]; other site 762550004940 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 762550004941 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 762550004942 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 762550004943 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 762550004944 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 762550004945 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762550004946 rRNA binding site [nucleotide binding]; other site 762550004947 predicted 30S ribosome binding site; other site 762550004948 adenylate kinase; Reviewed; Region: adk; PRK00279 762550004949 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762550004950 AMP-binding site [chemical binding]; other site 762550004951 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762550004952 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762550004953 SecY translocase; Region: SecY; pfam00344 762550004954 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 762550004955 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30_like; cl00203 762550004956 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762550004957 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762550004958 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762550004959 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762550004960 5S rRNA interface [nucleotide binding]; other site 762550004961 L27 interface [polypeptide binding]; other site 762550004962 23S rRNA interface [nucleotide binding]; other site 762550004963 L5 interface [polypeptide binding]; other site 762550004964 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762550004965 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762550004966 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762550004967 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 762550004968 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762550004969 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762550004970 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762550004971 KOW motif; Region: KOW; cl00354 762550004972 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 762550004973 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 762550004974 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 762550004975 putative translocon interaction site; other site 762550004976 23S rRNA interface [nucleotide binding]; other site 762550004977 signal recognition particle (SRP54) interaction site; other site 762550004978 L23 interface [polypeptide binding]; other site 762550004979 trigger factor interaction site; other site 762550004980 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762550004981 23S rRNA interface [nucleotide binding]; other site 762550004982 5S rRNA interface [nucleotide binding]; other site 762550004983 putative antibiotic binding site [chemical binding]; other site 762550004984 L25 interface [polypeptide binding]; other site 762550004985 L27 interface [polypeptide binding]; other site 762550004986 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762550004987 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 762550004988 G-X-X-G motif; other site 762550004989 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762550004990 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762550004991 putative translocon binding site; other site 762550004992 protein-rRNA interface [nucleotide binding]; other site 762550004993 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 762550004994 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762550004995 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762550004996 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762550004997 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 762550004998 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 762550004999 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 762550005000 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 762550005001 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762550005002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550005003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550005004 dimer interface [polypeptide binding]; other site 762550005005 conserved gate region; other site 762550005006 ABC-ATPase subunit interface; other site 762550005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550005008 dimer interface [polypeptide binding]; other site 762550005009 conserved gate region; other site 762550005010 putative PBP binding loops; other site 762550005011 ABC-ATPase subunit interface; other site 762550005012 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762550005013 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 762550005014 Walker A/P-loop; other site 762550005015 ATP binding site [chemical binding]; other site 762550005016 Q-loop/lid; other site 762550005017 ABC transporter signature motif; other site 762550005018 Walker B; other site 762550005019 D-loop; other site 762550005020 H-loop/switch region; other site 762550005021 TOBE domain; Region: TOBE_2; cl01440 762550005022 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 762550005023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005024 putative substrate translocation pore; other site 762550005025 elongation factor G; Reviewed; Region: PRK12739 762550005026 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 762550005027 G1 box; other site 762550005028 putative GEF interaction site [polypeptide binding]; other site 762550005029 GTP/Mg2+ binding site [chemical binding]; other site 762550005030 Switch I region; other site 762550005031 G2 box; other site 762550005032 G3 box; other site 762550005033 Switch II region; other site 762550005034 G4 box; other site 762550005035 G5 box; other site 762550005036 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 762550005037 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 762550005038 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 762550005039 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 762550005040 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762550005041 S17 interaction site [polypeptide binding]; other site 762550005042 S8 interaction site; other site 762550005043 16S rRNA interaction site [nucleotide binding]; other site 762550005044 streptomycin interaction site [chemical binding]; other site 762550005045 23S rRNA interaction site [nucleotide binding]; other site 762550005046 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762550005047 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 762550005048 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 762550005049 Clp protease ATP binding subunit; Region: clpC; CHL00095 762550005050 Clp amino terminal domain; Region: Clp_N; pfam02861 762550005051 Clp amino terminal domain; Region: Clp_N; pfam02861 762550005052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550005053 Walker A motif; other site 762550005054 ATP binding site [chemical binding]; other site 762550005055 Walker B motif; other site 762550005056 arginine finger; other site 762550005057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 762550005058 Walker A motif; other site 762550005059 ATP binding site [chemical binding]; other site 762550005060 Walker B motif; other site 762550005061 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550005062 peptide chain release factor 2; Validated; Region: prfB; PRK00578 762550005063 RF-1 domain; Region: RF-1; cl02875 762550005064 RF-1 domain; Region: RF-1; cl02875 762550005065 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762550005066 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762550005067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550005068 nucleotide binding region [chemical binding]; other site 762550005069 ATP-binding site [chemical binding]; other site 762550005070 seryl-tRNA synthetase; Provisional; Region: PRK05431 762550005071 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762550005072 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762550005073 dimer interface [polypeptide binding]; other site 762550005074 active site 762550005075 motif 1; other site 762550005076 motif 2; other site 762550005077 motif 3; other site 762550005078 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762550005079 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762550005080 active site 762550005081 HIGH motif; other site 762550005082 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762550005083 KMSKS motif; other site 762550005084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762550005085 tRNA binding surface [nucleotide binding]; other site 762550005086 anticodon binding site; other site 762550005087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 762550005088 substrate binding site [chemical binding]; other site 762550005089 hinge regions; other site 762550005090 ADP binding site [chemical binding]; other site 762550005091 catalytic site [active] 762550005092 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550005093 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550005094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550005095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005097 putative substrate translocation pore; other site 762550005098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550005099 Active site [active] 762550005100 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 762550005101 UvrD/REP helicase; Region: UvrD-helicase; cl14126 762550005102 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 762550005103 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762550005104 putative active site [active] 762550005105 putative FMN binding site [chemical binding]; other site 762550005106 putative substrate binding site [chemical binding]; other site 762550005107 putative catalytic residue [active] 762550005108 stage V sporulation protein B; Region: spore_V_B; TIGR02900 762550005109 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762550005110 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 762550005111 active site 762550005112 metal binding site [ion binding]; metal-binding site 762550005113 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762550005114 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762550005115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550005116 dimer interface [polypeptide binding]; other site 762550005117 conserved gate region; other site 762550005118 ABC-ATPase subunit interface; other site 762550005119 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762550005120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 762550005121 dimer interface [polypeptide binding]; other site 762550005122 conserved gate region; other site 762550005123 putative PBP binding loops; other site 762550005124 ABC-ATPase subunit interface; other site 762550005125 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 762550005126 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 762550005127 Walker A/P-loop; other site 762550005128 ATP binding site [chemical binding]; other site 762550005129 Q-loop/lid; other site 762550005130 ABC transporter signature motif; other site 762550005131 Walker B; other site 762550005132 D-loop; other site 762550005133 H-loop/switch region; other site 762550005134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550005135 putative transposase OrfB; Reviewed; Region: PHA02517 762550005136 Integrase core domain; Region: rve; cl01316 762550005137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550005138 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550005139 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 762550005140 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 762550005141 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 762550005142 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762550005143 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762550005144 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762550005145 alpha subunit interaction interface [polypeptide binding]; other site 762550005146 Walker A motif; other site 762550005147 ATP binding site [chemical binding]; other site 762550005148 Walker B motif; other site 762550005149 inhibitor binding site; inhibition site 762550005150 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762550005151 ATP synthase; Region: ATP-synt; cl00365 762550005152 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762550005153 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762550005154 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762550005155 beta subunit interaction interface [polypeptide binding]; other site 762550005156 Walker A motif; other site 762550005157 ATP binding site [chemical binding]; other site 762550005158 Walker B motif; other site 762550005159 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762550005160 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 762550005161 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762550005162 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 762550005163 ATP synthase subunit C; Region: ATP-synt_C; cl00466 762550005164 ATP synthase A chain; Region: ATP-synt_A; cl00413 762550005165 Sulfate transporter family; Region: Sulfate_transp; cl00967 762550005166 Permease family; Region: Xan_ur_permease; pfam00860 762550005167 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 762550005168 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 762550005169 G1 box; other site 762550005170 putative GEF interaction site [polypeptide binding]; other site 762550005171 GTP/Mg2+ binding site [chemical binding]; other site 762550005172 Switch I region; other site 762550005173 G2 box; other site 762550005174 G3 box; other site 762550005175 Switch II region; other site 762550005176 G4 box; other site 762550005177 G5 box; other site 762550005178 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 762550005179 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 762550005180 active site 762550005181 zinc binding site [ion binding]; other site 762550005182 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 762550005183 Bacitracin resistance protein BacA; Region: BacA; cl00858 762550005184 Haemolysin-III related; Region: HlyIII; cl03831 762550005185 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 762550005186 CrcB-like protein; Region: CRCB; cl09114 762550005187 CrcB-like protein; Region: CRCB; cl09114 762550005188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005189 non-specific DNA binding site [nucleotide binding]; other site 762550005190 salt bridge; other site 762550005191 sequence-specific DNA binding site [nucleotide binding]; other site 762550005192 short chain dehydrogenase; Provisional; Region: PRK05693 762550005193 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762550005194 NADP binding site [chemical binding]; other site 762550005195 active site 762550005196 steroid binding site; other site 762550005197 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 762550005198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005199 NAD(P) binding site [chemical binding]; other site 762550005200 active site 762550005201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550005202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005203 non-specific DNA binding site [nucleotide binding]; other site 762550005204 salt bridge; other site 762550005205 sequence-specific DNA binding site [nucleotide binding]; other site 762550005206 potential frameshift: common BLAST hit: gi|73661547|ref|YP_300328.1| phosphotransferase system cellobiose-specific component IIC 762550005207 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550005208 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550005209 Uncharacterized conserved protein [Function unknown]; Region: COG3589 762550005210 Uncharacterized conserved protein [Function unknown]; Region: COG3589 762550005211 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 762550005212 active site 762550005213 P-loop; other site 762550005214 phosphorylation site [posttranslational modification] 762550005215 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550005216 active site 762550005217 methionine cluster; other site 762550005218 phosphorylation site [posttranslational modification] 762550005219 metal binding site [ion binding]; metal-binding site 762550005220 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 762550005221 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cd00398 762550005222 intersubunit interface [polypeptide binding]; other site 762550005223 active site 762550005224 Zn2+ binding site [ion binding]; other site 762550005225 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 762550005226 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 762550005227 AP (apurinic/apyrimidinic) site pocket; other site 762550005228 DNA interaction; other site 762550005229 Metal-binding active site; metal-binding site 762550005230 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 762550005231 active site 762550005232 dimer interface [polypeptide binding]; other site 762550005233 magnesium binding site [ion binding]; other site 762550005234 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 762550005235 P-loop; other site 762550005236 active site 762550005237 phosphorylation site [posttranslational modification] 762550005238 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 762550005239 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762550005240 active site 762550005241 phosphorylation site [posttranslational modification] 762550005242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 762550005243 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550005244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550005245 active site 762550005246 motif I; other site 762550005247 motif II; other site 762550005248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550005249 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762550005250 metal binding site 2 [ion binding]; metal-binding site 762550005251 putative DNA binding helix; other site 762550005252 metal binding site 1 [ion binding]; metal-binding site 762550005253 dimer interface [polypeptide binding]; other site 762550005254 structural Zn2+ binding site [ion binding]; other site 762550005255 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550005256 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550005257 DNA binding site [nucleotide binding] 762550005258 domain linker motif; other site 762550005259 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550005260 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762550005261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005262 putative substrate translocation pore; other site 762550005263 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550005264 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 762550005265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550005266 dimerization interface [polypeptide binding]; other site 762550005267 putative DNA binding site [nucleotide binding]; other site 762550005268 putative Zn2+ binding site [ion binding]; other site 762550005269 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 762550005270 Cadmium resistance transporter; Region: Cad; cl04177 762550005271 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550005272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005273 putative substrate translocation pore; other site 762550005274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550005275 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 762550005276 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 762550005277 zinc binding site [ion binding]; other site 762550005278 putative ligand binding site [chemical binding]; other site 762550005279 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 762550005280 TM-ABC transporter signature motif; other site 762550005281 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 762550005282 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550005283 Walker A/P-loop; other site 762550005284 ATP binding site [chemical binding]; other site 762550005285 Q-loop/lid; other site 762550005286 ABC transporter signature motif; other site 762550005287 Walker B; other site 762550005288 D-loop; other site 762550005289 H-loop/switch region; other site 762550005290 K+ potassium transporter; Region: K_trans; cl01227 762550005291 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 762550005292 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550005293 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 762550005294 NAD binding site [chemical binding]; other site 762550005295 dimer interface [polypeptide binding]; other site 762550005296 substrate binding site [chemical binding]; other site 762550005297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550005298 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550005299 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 762550005300 putative transposase OrfB; Reviewed; Region: PHA02517 762550005301 Integrase core domain; Region: rve; cl01316 762550005302 recombination protein F; Reviewed; Region: recF; PRK00064 762550005303 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 762550005304 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 762550005305 putative active site [active] 762550005306 putative metal-binding site [ion binding]; other site 762550005307 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 762550005308 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 762550005309 putative active site [active] 762550005310 putative NTP binding site [chemical binding]; other site 762550005311 putative nucleic acid binding site [nucleotide binding]; other site 762550005312 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 762550005313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005314 ABC-2 type transporter; Region: ABC2_membrane; cl11417 762550005315 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762550005316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550005317 Walker A/P-loop; other site 762550005318 ATP binding site [chemical binding]; other site 762550005319 Q-loop/lid; other site 762550005320 ABC transporter signature motif; other site 762550005321 Walker B; other site 762550005322 D-loop; other site 762550005323 H-loop/switch region; other site 762550005324 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762550005325 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 762550005326 Acyl transferase domain; Region: Acyl_transf_1; cl08282 762550005327 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762550005328 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 762550005329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005330 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 762550005331 putative NADP binding site [chemical binding]; other site 762550005332 active site 762550005333 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 762550005334 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762550005335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550005336 catalytic residue [active] 762550005337 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 762550005338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 762550005339 active site 762550005340 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 762550005341 active site 762550005342 Integrase core domain; Region: rve; cl01316 762550005343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005344 non-specific DNA binding site [nucleotide binding]; other site 762550005345 salt bridge; other site 762550005346 sequence-specific DNA binding site [nucleotide binding]; other site 762550005347 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762550005348 Predicted helicase [General function prediction only]; Region: COG4889 762550005349 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 762550005350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005351 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550005352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 762550005353 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 762550005354 Walker A/P-loop; other site 762550005355 ATP binding site [chemical binding]; other site 762550005356 Q-loop/lid; other site 762550005357 ABC transporter signature motif; other site 762550005358 Walker B; other site 762550005359 D-loop; other site 762550005360 H-loop/switch region; other site 762550005361 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762550005362 TM-ABC transporter signature motif; other site 762550005363 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762550005364 TM-ABC transporter signature motif; other site 762550005365 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 762550005366 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 762550005367 Walker A/P-loop; other site 762550005368 ATP binding site [chemical binding]; other site 762550005369 Q-loop/lid; other site 762550005370 ABC transporter signature motif; other site 762550005371 Walker B; other site 762550005372 D-loop; other site 762550005373 H-loop/switch region; other site 762550005374 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 762550005375 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 762550005376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005380 putative substrate translocation pore; other site 762550005381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005382 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762550005383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005384 NAD(P) binding site [chemical binding]; other site 762550005385 active site 762550005386 Predicted transcriptional regulator [Transcription]; Region: COG1959 762550005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550005388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005390 Cation transport protein; Region: TrkH; cl10514 762550005391 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762550005392 Cation transport protein; Region: TrkH; cl10514 762550005393 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762550005394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005395 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 762550005396 D-lactate dehydrogenase; Provisional; Region: PRK11183 762550005397 FAD binding domain; Region: FAD_binding_4; pfam01565 762550005398 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 762550005399 OsmC-like protein; Region: OsmC; cl00767 762550005400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550005401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005403 putative substrate translocation pore; other site 762550005404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550005406 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550005407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 762550005408 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550005409 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550005410 active site 762550005411 methionine cluster; other site 762550005412 phosphorylation site [posttranslational modification] 762550005413 metal binding site [ion binding]; metal-binding site 762550005414 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 762550005415 active site 762550005416 P-loop; other site 762550005417 phosphorylation site [posttranslational modification] 762550005418 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 762550005419 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762550005420 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550005421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550005422 DNA-binding site [nucleotide binding]; DNA binding site 762550005423 UTRA domain; Region: UTRA; cl06649 762550005424 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762550005425 substrate binding site [chemical binding]; other site 762550005426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550005427 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762550005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005429 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 762550005430 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 762550005431 heterotetramer interface [polypeptide binding]; other site 762550005432 active site pocket [active] 762550005433 cleavage site 762550005434 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 762550005435 nucleotide binding site [chemical binding]; other site 762550005436 N-acetyl-L-glutamate binding site [chemical binding]; other site 762550005437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 762550005438 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 762550005439 inhibitor-cofactor binding pocket; inhibition site 762550005440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550005441 catalytic residue [active] 762550005442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005446 putative substrate translocation pore; other site 762550005447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005448 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 762550005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 762550005450 S-adenosylmethionine binding site [chemical binding]; other site 762550005451 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 762550005452 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 762550005453 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 762550005454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 762550005455 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 762550005456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550005457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 762550005458 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 762550005459 amphipathic channel; other site 762550005460 Asn-Pro-Ala signature motifs; other site 762550005461 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762550005462 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 762550005463 active site 762550005464 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762550005465 DNA binding residues [nucleotide binding] 762550005466 putative dimer interface [polypeptide binding]; other site 762550005467 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550005468 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762550005469 putative ADP-binding pocket [chemical binding]; other site 762550005470 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762550005471 Sulfatase; Region: Sulfatase; cl10460 762550005472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550005473 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 762550005474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550005475 active site 762550005476 motif I; other site 762550005477 motif II; other site 762550005478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 762550005479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005481 putative substrate translocation pore; other site 762550005482 aspartate aminotransferase; Provisional; Region: PRK07681 762550005483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550005484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550005485 homodimer interface [polypeptide binding]; other site 762550005486 catalytic residue [active] 762550005487 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762550005488 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 762550005489 putative active site [active] 762550005490 catalytic triad [active] 762550005491 putative dimer interface [polypeptide binding]; other site 762550005492 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 762550005493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 762550005494 substrate binding site [chemical binding]; other site 762550005495 oxyanion hole (OAH) forming residues; other site 762550005496 trimer interface [polypeptide binding]; other site 762550005497 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762550005498 CoenzymeA binding site [chemical binding]; other site 762550005499 subunit interaction site [polypeptide binding]; other site 762550005500 PHB binding site; other site 762550005501 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 762550005502 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762550005503 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 762550005504 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550005505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 762550005506 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 762550005507 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 762550005508 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 762550005509 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762550005510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550005511 Coenzyme A binding pocket [chemical binding]; other site 762550005512 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550005513 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 762550005514 active site 762550005515 catalytic site [active] 762550005516 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 762550005517 Ribonuclease P; Region: Ribonuclease_P; cl00457 762550005518 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 762550005519 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 762550005520 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 762550005521 Walker A/P-loop; other site 762550005522 ATP binding site [chemical binding]; other site 762550005523 Q-loop/lid; other site 762550005524 ABC transporter signature motif; other site 762550005525 Walker B; other site 762550005526 D-loop; other site 762550005527 H-loop/switch region; other site 762550005528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 762550005529 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 762550005530 Domain of unknown function DUF28; Region: DUF28; cl00361 762550005531 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566 762550005532 probable active site [active]